Thomas E. Smithgall
Affiliations: | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Molecular Biology, Oncology, BiochemistryGoogle:
"Thomas Smithgall"Mean distance: (not calculated yet)
Children
Sign in to add trainee| Ronald P. Trible | grad student | 2006 | University of Pittsburgh |
| Jonathan M. Shaffer | grad student | 2008 | University of Pittsburgh |
| Teodora Pene Dumitrescu | grad student | 2009 | University of Pittsburgh |
| Jerrod A. Poe | grad student | 2009 | University of Pittsburgh |
| Shoghag B. Panjarian | grad student | 2012 | University of Pittsburgh |
| Sreya Tarafdar | grad student | 2014 | University of Pittsburgh |
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Publications
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| Emert-Sedlak LA, Tice CM, Shi H, et al. (2024) PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication. Cell Chemical Biology |
| Peng WY, Abere B, Shi H, et al. (2023) Membrane-bound Merkel cell polyomavirus middle T protein constitutively activates PLCγ1 signaling through Src-family kinases. Proceedings of the National Academy of Sciences of the United States of America. 120: e2316467120 |
| Emert-Sedlak LA, Tice CM, Shi H, et al. (2023) PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication. Biorxiv : the Preprint Server For Biology |
| Heinrich F, Thomas CE, Jeff Alvarado J, et al. (2023) Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers. Journal of Molecular Biology. 168009 |
| Emert-Sedlak LA, Shi H, Tice CM, et al. (2022) Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor. Viruses. 14 |
| Aryal M, Lin D, Regan K, et al. (2022) The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction. Science Signaling. 15: eabn8359 |
| Du S, Alvarado JJ, Wales TE, et al. (2022) ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure (London, England : 1993) |
| Emert-Sedlak LA, Moukha-Chafiq O, Shi H, et al. (2022) Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation. Acs Infectious Diseases |
| Shu ST, Li WF, Smithgall TE. (2021) Visualization of Host Cell Kinase Activation by Viral Proteins Using GFP Fluorescence Complementation and Immunofluorescence Microscopy. Bio-Protocol. 11: e4068 |
| Staudt RP, Smithgall TE. (2020) Nef Homodimers Downregulate SERINC5 by AP-2-Mediated Endocytosis to Promote HIV-1 Infectivity. The Journal of Biological Chemistry |