David E. Cane, Ph.D.
Affiliations: | 1974-2016 | Chemistry | Brown University, Providence, RI |
Area:
Chemistry, Enzymology and Molecular Genetics of Natural Products BiosynthesisWebsite:
https://www.brown.edu/academics/chemistry/people/emeriti/david-caneGoogle:
"David Earl Cane" OR "David E. Cane"Bio:
https://www.gf.org/fellows/all-fellows/david-e-cane/
https://www.brown.edu/academics/chemistry/news/2016/05/congratulations-and-best-wishes-professor-david-cane-his-retirement
https://sites.google.com/a/brown.edu/david-e-cane---profile/home
https://scholar.google.com/citations?user=KSakIhkAAAAJ&hl=en
DOI: 10.1021/ja00754a055
Mean distance: 7.16 | S | N | B | C | P |
Parents
Sign in to add mentorElias James Corey | grad student | 1971 | Harvard | |
(The Alkyllithium Reagents for Organic Synthesis: The Synthesis of Racemic [a]- and [b]-trans-Bergamotene) | ||||
Duilio Arigoni | post-doc | 1973 | ETH Zürich |
Children
Sign in to add traineeStephen L. Buchwald | research assistant | 1977 | Brown |
Timothy M. Gregg | research assistant | 1989 | Brown |
Matthew H Levine | research assistant | 1991-1993 | Brown |
Jae Kyung Sohng | grad student | ||
Xun Guo | grad student | 2010- | Brown |
Ralph H Lambalot | grad student | 1989-1994 | Brown |
Ilgu Kang | grad student | 2000 | Brown |
Antonietta M. Lillo | grad student | 2002 | Brown |
Hongxiang Lu | grad student | 2003 | Brown |
Yifeng Yin | grad student | 2003 | Brown |
Brunella Felicetti | grad student | 2004 | Brown |
Guangzhi Zhai | grad student | 2004 | Brown |
Jerel Banks | grad student | 2006 | Brown |
Zheng You | grad student | 2007 | Brown |
Weiguo He | grad student | 2008 | Brown |
Jiaoyang Jiang | grad student | 2009 | Brown |
Chiara Rose Valenzano | grad student | 2004-2010 | Brown |
Chieh-Mei (Jamie) Wang | grad student | 2005-2010 | Brown |
Ashish Garg | post-doc | Brown | |
Dhara D Shah | post-doc | ||
Wayne Chou | post-doc | 2008- | Brown |
Myung-Ji Seo | post-doc | 2008- | Brown |
Young-Ok You | post-doc | 2008- | Brown |
Dongqing Zhu | post-doc | 2008- | Brown |
Yunfeng Hu | post-doc | 2009- | Brown |
Christopher Abell | post-doc | 1982-1983 | Brown |
Walter R. Ott | post-doc | 1986-1988 | Brown |
Paul Hedley Harrison | post-doc | 1987-1989 | Brown |
John S. Oliver | post-doc | 1988-1991 | Brown |
Youla Tsantrizos | post-doc | 1990-1991 | Brown |
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Publications
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Xie X, Cane DE. (2018) pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism. Organic & Biomolecular Chemistry |
Li X, Sevillano N, La Greca F, et al. (2018) Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society |
Xie X, Cane DE. (2018) Stereospecific Formation of Z-Trisubstituted Double Bonds by the Successive Action of Ketoreductase and Dehydratase Domains from trans-AT Polyketide Synthases. Biochemistry |
Cane D, Penny M, Marini A, et al. (2018) Updating the Competency Profile and Examination Blueprint for Entry-Level Optometry in Canada Canadian Journal of Optometry. 80: 25-34 |
Blank PN, Harris GG, Chou WKW, et al. (2017) Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry |
You YO, Shah DD, Cane DE. (2017) Stereospecific Formation of E- and Z- Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase. Journal of the American Chemical Society |
Xie X, Garg A, Khosla C, et al. (2017) Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. Journal of the American Chemical Society |
Xie X, Khosla C, Cane DE. (2017) Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. Journal of the American Chemical Society |
Pemberton TA, Chen M, Harris GG, et al. (2017) Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry |
Chou WK, Gould CA, Cane DE. (2017) Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate. The Journal of Antibiotics |