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Graham M. West, Ph.D. - Publications

Affiliations: 
2009 Chemistry Duke University, Durham, NC 
Area:
protein folding and stability
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Tallon AM, Xu Y, West GM, Am Ende CW, Fox JM. Thiomethyltetrazines Are Reversible Covalent Cysteine Warheads Whose Dynamic Behavior can be "Switched Off" Bioorthogonal Chemistry Inside Live Cells. Journal of the American Chemical Society. PMID 37450839 DOI: 10.1021/jacs.3c04444  0.331
2021 Xu Y, West GM, Abdelmessih M, Troutman MD, Everley RA. A Comparison of Two Stability Proteomics Methods for Drug Target Identification in OnePot 2D Format. Acs Chemical Biology. PMID 34374519 DOI: 10.1021/acschembio.1c00317  0.394
2020 Hesp KD, Xiao J, West GM. Late-stage synthesis and application of photoreactive probes derived from direct benzoylation of heteroaromatic C-H bonds. Organic & Biomolecular Chemistry. PMID 32373883 DOI: 10.1039/D0Ob00336K  0.316
2018 Bandyopadhyay A, Van Eps N, Eger BT, Rauscher S, Yedidi RS, Moroni T, West GM, Robinson KA, Griffin PR, Mitchell J, Ernst OP. A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin. Journal of Molecular Biology. PMID 30120952 DOI: 10.1016/J.Jmb.2018.08.009  0.382
2018 Zorba A, Nguyen C, Xu Y, Starr J, Borzilleri K, Smith J, Zhu H, Farley KA, Ding W, Schiemer J, Feng X, Chang JS, Uccello DP, Young JA, Garcia-Irrizary CN, ... ... West GM, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proceedings of the National Academy of Sciences of the United States of America. PMID 30012605 DOI: 10.1073/Pnas.1803662115  0.434
2018 Byrnes LJ, Xu Y, Qiu X, Hall JD, West GM. Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange. Scientific Reports. 8: 4664. PMID 29549268 DOI: 10.1038/S41598-018-22959-6  0.377
2018 Kurumbail RG, West GM, Dharmarajan V, Borzilleri KA, Withka JM, Ward J, Reyes AR, Rajamohan F, Griffin PR, Calabrese MF. Biophysical Interactions of Direct AMPK Activators. Methods in Molecular Biology (Clifton, N.J.). 1732: 29-55. PMID 29480467 DOI: 10.1007/978-1-4939-7598-3_3  0.5
2017 Nguyen C, West GM, Geoghegan KF. Emerging Methods in Chemoproteomics with Relevance to Drug Discovery. Methods in Molecular Biology (Clifton, N.J.). 1513: 11-22. PMID 27807827 DOI: 10.1007/978-1-4939-6539-7_2  0.473
2016 Zuhl AM, Nolan CE, Brodney MA, Niessen S, Atchison K, Houle C, Karanian DA, Ambroise C, Brulet JW, Beck EM, Doran SD, O'Neill BT, Am Ende CW, Chang C, Geoghegan KF, ... West GM, et al. Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors. Nature Communications. 7: 13042. PMID 27727204 DOI: 10.1038/Ncomms13042  0.32
2016 Li J, Xu H, West GM, Jones LH. Label-free technologies for target identification and validation Medchemcomm. 7: 769-777. DOI: 10.1039/C6Md00045B  0.335
2015 Mari Y, West GM, Scharager-Tapia C, Pascal BD, Garcia-Ordonez RD, Griffin PR. SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex. Journal of Proteome Research. 14: 4571-80. PMID 26398198 DOI: 10.1021/Acs.Jproteome.5B00379  0.363
2015 Pascal BD, West GM, Scharager-Tapia C, Flefil R, Moroni T, Martinez-Acedo P, Griffin PR, Carvalloza AC. Software Analysis of Uncorrelated MS1 Peaks for Discovery of Post-Translational Modifications. Journal of the American Society For Mass Spectrometry. PMID 26265041 DOI: 10.1007/S13361-015-1229-4  0.315
2015 Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, et al. Conformational states of the full-length glucagon receptor. Nature Communications. 6: 7859. PMID 26227798 DOI: 10.1038/Ncomms8859  0.393
2015 Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, ... ... West GM, et al. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature. PMID 26200343 DOI: 10.1038/Nature14656  0.376
2015 Adhikari J, West GM, Fitzgerald MC. Global analysis of protein folding thermodynamics for disease state characterization. Journal of Proteome Research. 14: 2287-97. PMID 25825992 DOI: 10.1021/Acs.Jproteome.5B00057  0.584
2015 Corzo CA, Mari Y, Chang MR, Khan T, Kuruvilla D, Nuhant P, Kumar N, West GM, Duckett DR, Roush WR, Griffin PR. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Molecular Pharmacology. 87: 296-304. PMID 25473120 DOI: 10.1124/Mol.114.095554  0.32
2014 Honarmand Ebrahimi K, West GM, Flefil R. Mass spectrometry approach and ELISA reveal the effect of codon optimization on N-linked glycosylation of HIV-1 gp120. Journal of Proteome Research. 13: 5801-11. PMID 25285362 DOI: 10.1021/Pr500740N  0.301
2014 West GM, Willard FS, Sloop KW, Showalter AD, Pascal BD, Griffin PR. Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain. Plos One. 9: e105683. PMID 25180755 DOI: 10.1371/Journal.Pone.0105683  0.401
2014 Rust HL, Subramanian V, West GM, Young DD, Schultz PG, Thompson PR. Using unnatural amino acid mutagenesis to probe the regulation of PRMT1. Acs Chemical Biology. 9: 649-55. PMID 24358983 DOI: 10.1021/Cb400859Z  0.352
2013 West GM, Pascal BD, Ng LM, Soon FF, Melcher K, Xu HE, Chalmers MJ, Griffin PR. Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities. Structure (London, England : 1993). 21: 229-35. PMID 23290725 DOI: 10.1016/J.Str.2012.12.001  0.391
2013 Strickland EC, Geer MA, Tran DT, Adhikari J, West GM, DeArmond PD, Xu Y, Fitzgerald MC. Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation. Nature Protocols. 8: 148-61. PMID 23257983 DOI: 10.1038/Nprot.2012.146  0.756
2012 Pascal BD, Willis S, Lauer JL, Landgraf RR, West GM, Marciano D, Novick S, Goswami D, Chalmers MJ, Griffin PR. HDX workbench: software for the analysis of H/D exchange MS data. Journal of the American Society For Mass Spectrometry. 23: 1512-21. PMID 22692830 DOI: 10.1007/S13361-012-0419-6  0.333
2012 Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, et al. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (New York, N.Y.). 335: 85-8. PMID 22116026 DOI: 10.1126/Science.1215106  0.332
2012 Griffin P, West G, Chalmers M, Landgraf R, Zhang J. Structure Activity Relationships of Nuclear Receptor, GPCR and Kinase Modulators Revealed with Differential HDX Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.019  0.528
2011 West GM, Chien EY, Katritch V, Gatchalian J, Chalmers MJ, Stevens RC, Griffin PR. Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. Structure (London, England : 1993). 19: 1424-32. PMID 21889352 DOI: 10.1016/J.Str.2011.08.001  0.428
2011 DeArmond PD, West GM, Huang HT, Fitzgerald MC. Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures. Journal of the American Society For Mass Spectrometry. 22: 418-30. PMID 21472561 DOI: 10.1007/S13361-010-0060-1  0.754
2011 Chalmers MJ, Busby SA, Pascal BD, West GM, Griffin PR. Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. Expert Review of Proteomics. 8: 43-59. PMID 21329427 DOI: 10.1586/Epr.10.109  0.555
2010 Dearmond PD, West GM, Anbalagan V, Campa MJ, Patz EF, Fitzgerald MC. Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy. Journal of Biomolecular Screening. 15: 1051-62. PMID 20855564 DOI: 10.1177/1087057110382775  0.708
2010 West GM, Thompson JW, Soderblom EJ, Dubois LG, Dearmond PD, Moseley MA, Fitzgerald MC. Mass spectrometry-based thermal shift assay for protein-ligand binding analysis. Analytical Chemistry. 82: 5573-81. PMID 20527820 DOI: 10.1021/Ac100465A  0.749
2010 West GM, Tucker CL, Xu T, Park SK, Han X, Yates JR, Fitzgerald MC. Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. Proceedings of the National Academy of Sciences of the United States of America. 107: 9078-82. PMID 20439767 DOI: 10.1073/Pnas.1000148107  0.651
2009 Fitzgerald MC, West GM. Painting proteins with covalent labels: what's in the picture? Journal of the American Society For Mass Spectrometry. 20: 1193-206. PMID 19269190 DOI: 10.1016/J.Jasms.2009.02.006  0.701
2008 West GM, Tang L, Fitzgerald MC. Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy. Analytical Chemistry. 80: 4175-85. PMID 18457414 DOI: 10.1021/Ac702610A  0.728
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