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David C. Smithson, Ph.D. - Publications

Affiliations: 
2009 Chemistry and Chemical Biology University of California, San Francisco, San Francisco, CA 
Area:
Medicinal Chemistry
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports. PMID 29871975 DOI: 10.1042/Bsr20180231_Cor  0.413
2018 Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Bioscience Reports. PMID 29472314 DOI: 10.1042/Bsr20180231  0.484
2017 Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, et al. Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. Plos Neglected Tropical Diseases. 11: e0006157. PMID 29287089 DOI: 10.1371/Journal.Pntd.0006157  0.729
2016 Zhang J, Bowling JJ, Smithson D, Clark J, Jacob MR, Khan SI, Tekwani BL, Connelly M, Samoylenko V, Ibrahim MA, Zaki MA, Wang M, Hester JP, Tu Y, Jeffries C, et al. Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum. Malaria Journal. 15: 270. PMID 27165106 DOI: 10.1186/S12936-016-1313-7  0.66
2015 Madoux F, Janovick JA, Smithson D, Fargue S, Danpure CJ, Scampavia L, Chen YT, Spicer TP, Conn PM. Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening. Assay and Drug Development Technologies. 13: 16-24. PMID 25710543 DOI: 10.1089/adt.2014.627  0.313
2014 Yang J, Liang Q, Wang M, Jeffries C, Smithson D, Tu Y, Boulos N, Jacob MR, Shelat AA, Wu Y, Ravu RR, Gilbertson R, Avery MA, Khan IA, Walker LA, et al. UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. Journal of Natural Products. 77: 902-9. PMID 24617915 DOI: 10.1021/Np4009706  0.674
2014 Conn PM, Smithson DC, Hodder PS, Stewart MD, Behringer RR, Smith E, Ulloa-Aguirre A, Janovick JA. Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 83: 38-51. PMID 24373832 DOI: 10.1016/J.Phrs.2013.12.004  0.316
2013 Hwang JY, Smithson DC, Holbrook G, Zhu F, Connelly MC, Kaiser M, Brun R, Kiplin Guy R. Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. Bioorganic & Medicinal Chemistry Letters. 23: 4127-31. PMID 23746473 DOI: 10.1016/j.bmcl.2013.05.049  0.646
2013 Conn PM, Smith E, Hodder P, Janovick JA, Smithson DC. High-throughput screen for pharmacoperones of the vasopressin type 2 receptor. Journal of Biomolecular Screening. 18: 930-7. PMID 23640875 DOI: 10.1177/1087057113483559  0.323
2013 Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK. Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry. 56: 2850-60. PMID 23484493 DOI: 10.1021/jm301687p  0.659
2012 Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. Plos One. 7: e37518. PMID 22675482 DOI: 10.1371/journal.pone.0037518  0.722
2010 Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, et al. Chemical genetics of Plasmodium falciparum. Nature. 465: 311-5. PMID 20485428 DOI: 10.1038/Nature09099  0.663
2010 Tu Y, Jeffries C, Ruan H, Nelson C, Smithson D, Shelat AA, Brown KM, Li XC, Hester JP, Smillie T, Khan IA, Walker L, Guy K, Yan B. Automated high-throughput system to fractionate plant natural products for drug discovery. Journal of Natural Products. 73: 751-4. PMID 20232897 DOI: 10.1021/Np9007359  0.564
2010 Smithson DC, Lee J, Shelat AA, Phillips MA, Guy RK. Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase. The Journal of Biological Chemistry. 285: 16771-81. PMID 20220141 DOI: 10.1074/Jbc.M109.081588  0.693
2010 Uddin MJ, Smithson DC, Brown KM, Crews BC, Connelly M, Zhu F, Marnett LJ, Guy RK. Podophyllotoxin analogues active versus Trypanosoma brucei. Bioorganic & Medicinal Chemistry Letters. 20: 1787-91. PMID 20129783 DOI: 10.1016/J.Bmcl.2010.01.009  0.572
2010 Smithson DC, Shelat AA, Baldwin J, Phillips MA, Guy RK. Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes. Assay and Drug Development Technologies. 8: 175-85. PMID 20085486 DOI: 10.1089/Adt.2009.0249  0.644
2010 Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Identification and characterization of the first small molecule inhibitor of MDMX. The Journal of Biological Chemistry. 285: 10786-96. PMID 20080970 DOI: 10.1074/Jbc.M109.056747  0.648
2010 Hwang JY, Smithson D, Connelly M, Maier J, Zhu F, Guy KR. Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis. Bioorganic & Medicinal Chemistry Letters. 20: 149-52. PMID 19963377 DOI: 10.1016/j.bmcl.2009.11.022  0.645
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