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Robert Britton - Publications

Affiliations: 
Simon Fraser University, Burnaby, British Columbia, Canada 
Area:
organic chemistry
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66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wilson DM, Britton R. Enantioselective Total Synthesis of the Marine Macrolides Salarins A and C. Journal of the American Chemical Society. PMID 38479352 DOI: 10.1021/jacs.3c14553  0.339
2023 Kaghad A, Panagopoulos D, Caballero-García G, Zhai H, Britton R. An α-chloroaldehyde-based formal synthesis of eribulin. Nature Communications. 14: 1904. PMID 37019928 DOI: 10.1038/s41467-023-37346-7  0.33
2022 Davison EK, Petrone DA, Meanwell M, Nodwell MB, Silverman SM, Campeau LC, Britton R. Practical and concise synthesis of nucleoside analogs. Nature Protocols. PMID 35788720 DOI: 10.1038/s41596-022-00705-7  0.34
2021 Meanwell M, Fehr G, Ren W, Adluri B, Rose V, Lehmann J, Silverman SM, Rowshanpour R, Adamson C, Bergeron-Brlek M, Foy H, Challa VR, Campeau LC, Dudding T, Britton R. Diversity-oriented synthesis of glycomimetics. Communications Chemistry. 4: 96. PMID 36697548 DOI: 10.1038/s42004-021-00520-3  0.785
2021 Challa VR, Kwon D, Taron M, Fan H, Kang B, Wilson D, Haeckl FPJ, Keerthisinghe S, Linington RG, Britton R. Total synthesis of biselide A. Chemical Science. 12: 5534-5543. PMID 34168790 DOI: 10.1039/d0sc06223e  0.815
2020 Meanwell M, Silverman SM, Lehmann J, Adluri B, Wang Y, Cohen R, Campeau LC, Britton R. A short de novo synthesis of nucleoside analogs. Science (New York, N.Y.). 369: 725-730. PMID 32764073 DOI: 10.1126/Science.Abb3231  0.784
2020 Ndukwe IE, Wang X, Lam NYS, Ermanis K, Alexander KL, Bertin MJ, Martin GE, Muir G, Paterson I, Britton R, Goodman JM, Helfrich EJN, Piel J, Gerwick WH, Williamson RT. Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A. Chemical Communications (Cambridge, England). PMID 32520016 DOI: 10.1039/D0Cc03055D  0.617
2020 Newton JJ, Jelier BJ, Meanwell M, Martin RE, Britton R, Friesen CM. Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF. Organic Letters. PMID 32053386 DOI: 10.1021/Acs.Orglett.0C00099  0.389
2020 Ren W, Farren-Dai M, Sannikova N, Świderek K, Wang Y, Akintola O, Britton R, Moliner V, Bennet AJ. Glycoside Hydrolase Stabilization of Transition State Charge: New Directions for Inhibitor Design Chemical Science. DOI: 10.1039/D0Sc04401F  0.319
2019 Newton J, Driedger D, Nodwell MB, Schaffer P, Martin RE, Britton R, Friesen CM. A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters using Silver(I) Fluoride. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31538366 DOI: 10.1002/Chem.201904132  0.451
2019 Lam NYS, Muir G, Challa VR, Britton R, Paterson I. A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A. Chemical Communications (Cambridge, England). PMID 31353378 DOI: 10.1039/C9Cc05067A  0.559
2019 Ren W, Gries R, Kurita KL, McCaughey CS, Alamsetti SK, Linington RG, Gries G, Britton R. Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets. Journal of Natural Products. PMID 31244148 DOI: 10.1021/Acs.Jnatprod.9B00238  0.356
2019 Yuan Z, Yang H, Malik N, Čolović M, Weber DS, Wilson D, Bénard F, Martin RE, Warren JJ, Schaffer P, Britton R. Electrostatic Effects Accelerate Decatungstate-Catalyzed C–H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics Acs Catalysis. 9: 8276-8284. DOI: 10.1021/Acscatal.9B02220  0.371
2018 Newton JJ, Britton R, Friesen CM. Base-Catalyzed Transesterification of Thionoesters. The Journal of Organic Chemistry. PMID 30235418 DOI: 10.1021/Acs.Joc.8B02260  0.429
2018 Meanwell M, Lehmann J, Eichenberger M, Martin RE, Britton R. Synthesis of acyl fluorides via photocatalytic fluorination of aldehydic C-H bonds. Chemical Communications (Cambridge, England). PMID 30123905 DOI: 10.1039/C8Cc06375C  0.447
2018 Ren W, Pengelly R, Farren-Dai M, Shamsi Kazem Abadi S, Oehler V, Akintola O, Draper J, Meanwell M, Chakladar S, Świderek K, Moliner V, Britton R, Gloster TM, Bennet AJ. Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nature Communications. 9: 3243. PMID 30104598 DOI: 10.1038/S41467-018-05702-7  0.343
2018 Meanwell M, Adluri BS, Yuan Z, Newton J, Prevost P, Nodwell MB, Friesen CM, Schaffer P, Martin RE, Britton R. Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives. Chemical Science. 9: 5608-5613. PMID 30061993 DOI: 10.1039/C8Sc01221K  0.758
2018 Meanwell M, Sutherland M, Britton R. Application of sequential proline-catalyzed α-chlorination and aldol reactions in the total synthesis of 1-deoxygalactonojirimycin Canadian Journal of Chemistry. 96: 144-147. DOI: 10.1139/Cjc-2017-0318  0.518
2018 Britton R, Meanwell M. Synthesis of Heterobenzylic Fluorides Synthesis. 50: 1228-1236. DOI: 10.1055/S-0036-1589159  0.382
2016 Chang S, Holmes M, Mowat J, Meanwell M, Britton R. α-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones. Angewandte Chemie (International Ed. in English). PMID 27976511 DOI: 10.1002/Anie.201608449  0.793
2016 Adamson C, Pengelly RJ, Shamsi Kazem Abadi S, Chakladar S, Draper J, Britton R, Gloster TM, Bennet AJ. Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars. Angewandte Chemie (International Ed. in English). PMID 27783466 DOI: 10.1002/Anie.201607431  0.357
2016 Meanwell M, Nodwell MB, Martin RE, Britton R. A Convenient Late-Stage Fluorination of Pyridylic C-H Bonds with N-Fluorobenzenesulfonimide. Angewandte Chemie (International Ed. in English). PMID 27653634 DOI: 10.1002/Anie.201606323  0.333
2016 Martin RE, Lehmann J, Alzieu T, Lenz M, Carnero Corrales MA, Aebi JD, Märki HP, Kuhn B, Amrein K, Mayweg AV, Britton R. Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2). Organic & Biomolecular Chemistry. PMID 27245438 DOI: 10.1039/C6Ob00848H  0.376
2016 Zhai H, Hrabar M, Gries R, Gries G, Britton R. Total Synthesis, Stereochemical Assignment, and Field-Testing of the Sex Pheromone of the Strepsipteran Xenos peckii. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27001535 DOI: 10.1002/Chem.201505097  0.341
2016 Zhai H, Hrabar M, Gries R, Gries G, Britton R. Back Cover: Total Synthesis, Stereochemical Assignment, and Field-Testing of the Sex Pheromone of the StrepsipteranXenos peckii(Chem. Eur. J. 18/2016) Chemistry - a European Journal. 22: 6408-6408. DOI: 10.1002/Chem.201601010  0.313
2015 Halperin SD, Kwon D, Holmes M, Regalado EL, Campeau LC, DiRocco DA, Britton R. Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib. Organic Letters. 17: 5200-3. PMID 26484983 DOI: 10.1021/Acs.Orglett.5B02532  0.451
2015 Chang S, Hur S, Britton R. Total Synthesis and Configurational Assignment of Ascospiroketal A. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26424097 DOI: 10.1002/Chem.201502754  0.468
2015 Holmes M, Kwon D, Taron M, Britton R. Total Synthesis of Amphirionin-4. Organic Letters. 17: 3868-71. PMID 26172382 DOI: 10.1021/Acs.Orglett.5B01844  0.38
2015 Bergeron-Brlek M, Meanwell M, Britton R. Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars. Nature Communications. 6: 6903. PMID 25903019 DOI: 10.1038/Ncomms7903  0.434
2015 Chang S, Hur S, Britton R. Total synthesis of ascospiroketal a through a Ag(I) -promoted cyclization cascade. Angewandte Chemie (International Ed. in English). 54: 211-4. PMID 25377217 DOI: 10.1002/Anie.201408905  0.428
2014 Alzieu T, Lehmann J, Naidu AB, Martin RE, Britton R. Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis. Chemical Communications (Cambridge, England). 50: 1867-70. PMID 24402236 DOI: 10.1039/C3Cc48467J  0.469
2013 Holmes MT, Britton R. Total synthesis and structural revision of laurefurenynes A and B. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 12649-52. PMID 23956022 DOI: 10.1002/Chem.201302352  0.442
2013 Dhand V, Chang S, Britton R. Total synthesis of the cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B). The Journal of Organic Chemistry. 78: 8208-13. PMID 23919543 DOI: 10.1021/jo4013223  0.366
2013 Bergeron-Brlek M, Teoh T, Britton R. A tandem organocatalytic α-chlorination-aldol reaction that proceeds with dynamic kinetic resolution: a powerful tool for carbohydrate synthesis. Organic Letters. 15: 3554-7. PMID 23819733 DOI: 10.1021/Ol401370B  0.449
2013 Lehmann J, Alzieu T, Martin RE, Britton R. The Kondrat'eva reaction in flow: direct access to annulated pyridines. Organic Letters. 15: 3550-3. PMID 23805911 DOI: 10.1021/Ol4013525  0.396
2013 Dhand V, Draper JA, Moore J, Britton R. A short, organocatalytic formal synthesis of (-)-swainsonine and related alkaloids. Organic Letters. 15: 1914-7. PMID 23550817 DOI: 10.1021/Ol400566J  0.471
2013 Halperin SD, Britton R. Chlorine, an atom economical auxiliary for asymmetric aldol reactions. Organic & Biomolecular Chemistry. 11: 1702-5. PMID 23370443 DOI: 10.1039/C3Ob27462D  0.405
2013 Britton R, Kang B. α-Haloaldehydes: versatile building blocks for natural product synthesis. Natural Product Reports. 30: 227-36. PMID 23258610 DOI: 10.1039/C2Np20108A  0.808
2013 Mowat J, Senior J, Kang B, Britton R. Scalable synthesis of the pink gypsy moth Lymantria mathura sex pheromone (-)-mathuralure Canadian Journal of Chemistry. 91: 235-239. DOI: 10.1139/cjc-2012-0376  0.78
2013 Qadoumi Z, Senior J, Bergeron-Brlek M, Britton R. Direct access to iminosugars through an interrupted kondrat'eva reaction Synlett. 24: 2427-2430. DOI: 10.1055/S-0033-1339905  0.766
2013 Chang S, Desai S, Leznoff DB, Merbouh N, Britton R. A short, gram-scale synthesis of 2,5-disubstituted furans European Journal of Organic Chemistry. 3219-3222. DOI: 10.1002/Ejoc.201300305  0.467
2012 Chang S, Britton R. Enantioselective synthesis of spiroacetals via silver(I)-promoted alkylation of hemiacetals: total synthesis of cephalosporolides E and F. Organic Letters. 14: 5844-7. PMID 23145960 DOI: 10.1021/Ol302694S  0.41
2012 Zerbe P, Chiang A, Yuen M, Hamberger B, Hamberger B, Draper JA, Britton R, Bohlmann J. Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production. The Journal of Biological Chemistry. 287: 12121-31. PMID 22337889 DOI: 10.1074/Jbc.M111.317669  0.314
2011 Cho I, Meimetis L, Belding L, Katz MJ, Dudding T, Britton R. Directed ortho,ortho'-dimetalation of hydrobenzoin: Rapid access to hydrobenzoin derivatives useful for asymmetric synthesis. Beilstein Journal of Organic Chemistry. 7: 1315-22. PMID 22043241 DOI: 10.3762/Bjoc.7.154  0.459
2011 Halperin SD, Kang B, Britton R. Lithium aldol reactions of α-chloroaldehydes provide versatile building blocks for natural product synthesis Synthesis. 1946-1953. DOI: 10.1055/S-0030-1260032  0.809
2010 Draper JA, Britton R. A concise and stereoselective synthesis of hydroxypyrrolidines: rapid synthesis of (+)-preussin. Organic Letters. 12: 4034-7. PMID 20726562 DOI: 10.1021/Ol101631E  0.456
2010 Kang B, Chang S, Decker S, Britton R. Regioselective and stereoselective cyclizations of chloropolyols in water: rapid synthesis of hydroxytetrahydrofurans. Organic Letters. 12: 1716-9. PMID 20297827 DOI: 10.1021/Ol100260Z  0.808
2010 Paterson I, Britton R, Delgado O, Gardner NM, Meyer A, Naylor GJ, Poullennec KG. Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin Tetrahedron. 66: 6534-6545. DOI: 10.1016/J.Tet.2010.01.083  0.555
2009 Mowat J, Gries R, Khaskin G, Gries G, Britton R. (S)-2-pentyl (R)-3-hydroxyhexanoate, a banana volatile and its olfactory recognition by the common fruit fly, Drosophila melanogaster. Journal of Natural Products. 72: 772-6. PMID 19388708 DOI: 10.1021/Np800597K  0.767
2009 Mowat J, Kang B, Fonovic B, Dudding T, Britton R. Inverse temperature dependence in the diastereoselective addition of Grignard reagents to a tetrahydrofurfural. Organic Letters. 11: 2057-60. PMID 19326896 DOI: 10.1021/Ol900324S  0.739
2009 Cho I, Meimetis L, Britton R. Bidirectional metalation of hydrobenzoin: direct access to new chiral ligands and auxiliaries. Organic Letters. 11: 1903-6. PMID 19326895 DOI: 10.1021/Ol900323U  0.355
2009 Kang B, Mowat J, Pinter T, Britton R. Development of a concise and general enantioselective approach to 2,5-disubstituted-3-hydroxytetrahydrofurans. Organic Letters. 11: 1717-20. PMID 19323544 DOI: 10.1021/Ol802711S  0.743
2008 Paterson I, Ashton K, Britton R, Cecere G, Chouraqui G, Florence GJ, Knust H, Stafford J. Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea. Chemistry, An Asian Journal. 3: 367-87. PMID 18181126 DOI: 10.1002/Asia.200700357  0.777
2007 Kang B, Britton R. A general method for the synthesis of nonracemic trans-epoxides: concise syntheses of trans-epoxide-containing insect sex pheromones. Organic Letters. 9: 5083-6. PMID 17975920 DOI: 10.1021/ol702273n  0.805
2007 Paterson I, Ashton K, Britton R, Cecere G, Chouraqui G, Florence GJ, Stafford J. Total synthesis of (-)-reidispongiolide A, an actin-targeting marine macrolide. Angewandte Chemie (International Ed. in English). 46: 6167-71. PMID 17615611 DOI: 10.1002/Anie.200702178  0.758
2007 Gosselin F, Britton RA, Mowat J, O'Shea PD, Davies IW. Asymmetric organozincate additions to ethyl 2,2,2-trifluoropyruvate Synlett. 2193-2196. DOI: 10.1055/S-2007-984911  0.787
2005 Paterson I, Menche D, Britton R, Håkansson AE, Silva-Martínez MA. Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling Tetrahedron Letters. 46: 3677-3682. DOI: 10.1016/J.Tetlet.2005.03.149  0.589
2004 Jiang X, Zhao B, Britton R, Lim LY, Leong D, Sanghera JS, Zhou BB, Piers E, Andersen RJ, Roberge M. Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. Molecular Cancer Therapeutics. 3: 1221-7. PMID 15486189  0.532
2004 Paterson I, Britton R, Delgado O, Meyer A, Poullennec KG. Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin. Angewandte Chemie (International Ed. in English). 43: 4629-33. PMID 15317000 DOI: 10.1002/Anie.200460589  0.454
2004 Paterson I, Britton R, Ashton K, Knust H, Stafford J. Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A Proceedings of the National Academy of Sciences of the United States of America. 101: 11986-11991. PMID 15201432 DOI: 10.1073/Pnas.0401548101  0.479
2004 Britton RA, Piers E, Patrick BO. Total synthesis of (+/-)-13-methoxy-15-oxozoapatlin, a rearranged kaurane diterpenoid. The Journal of Organic Chemistry. 69: 3068-75. PMID 15104445 DOI: 10.1002/CHIN.200435177  0.647
2004 Paterson I, Britton R, Delgado O, Wright AE. Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp. Chemical Communications (Cambridge, England). 632-3. PMID 15010754 DOI: 10.1039/B316390C  0.415
2003 Paterson I, Ashton K, Britton R, Knust H. Toward the synthesis of reidispongiolide A: Stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments Organic Letters. 5: 1963-1966. PMID 12762697 DOI: 10.1021/Ol034558Y  0.518
2000 Piers E, Britton R, Andersen RJ. Improved synthesis of isogranulatimide, a G2 checkpoint inhibitor. Syntheses Of didemnimide C, isodidemnimide A, neodidemnimide A, 17-methylgranulatimide, and isogranulatimides A-C. The Journal of Organic Chemistry. 65: 530-5. PMID 10813968 DOI: 10.1021/Jo9914723  0.601
1998 Roberge M, Berlinck RG, Xu L, Anderson HJ, Lim LY, Curman D, Stringer CM, Friend SH, Davies P, Vincent I, Haggarty SJ, Kelly MT, Britton R, Piers E, Andersen RJ. High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide. Cancer Research. 58: 5701-6. PMID 9865726  0.545
1998 Berlmck RGS, Britton R, Piers E, Lim L, Roberge M, Rosana Moreira Da Rocha, Andersen RJ. Granulatimide and isogranulatimide, aromatic alkaloids with G2 checkpoint inhibition activity isolated from the Brazilian ascidian Didemnum granulatum: Structure elucidation and synthesis Journal of Organic Chemistry. 63: 9850-9856. DOI: 10.1021/Jo981607P  0.579
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