William H. Gerwick, Ph.D. - Publications

Affiliations: 
2005- Marine Biotechnology and Biomedicine Scripps Institution of Oceanography, San Diego, California 
Area:
bioactive molecules with anticancer, antibacterial, neurotoxic, antiviral, or anti-inflammatory activity from marine organisms
Website:
http://pharmacy.ucsd.edu/faculty/bios/Gerwick.shtml

272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cao L, Gurevich A, Alexander KL, Naman CB, Leão T, Glukhov E, Luzzatto-Knaan T, Vargas F, Quinn R, Bouslimani A, Nothias LF, Singh NK, Sanders JG, Benitez RAS, Thompson LR, ... ... Gerwick WH, et al. MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cell Systems. PMID 31629686 DOI: 10.1016/j.cels.2019.09.004  0.68
2019 Boudreau PD, Miller BW, McCall LI, Almaliti J, Reher R, Hirata K, Le T, Siqueira-Neto JL, Hook VYH, Gerwick WH. Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain. Journal of Medicinal Chemistry. PMID 31539239 DOI: 10.1021/acs.jmedchem.9b00294  0.4
2019 Yu HB, Glukhov E, Li Y, Iwasaki A, Gerwick L, Dorrestein PC, Jiao BH, Gerwick WH. Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium . Journal of Natural Products. PMID 31468974 DOI: 10.1021/acs.jnatprod.9b00549  0.68
2019 O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. 20S proteasome as a drug target in . Antimicrobial Agents and Chemotherapy. PMID 31451503 DOI: 10.1128/AAC.00448-19  0.4
2019 Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki B, El-Sakkary N, Hook VYH, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. The proteasome as a drug target in the metazoan pathogen, . Acs Infectious Diseases. PMID 31355632 DOI: 10.1021/acsinfecdis.9b00237  0.4
2019 Moss NA, Seiler G, Leão TF, Castro-Falcón G, Gerwick L, Hughes CC, Gerwick WH. Nature's combinatorial biosynthesis produces vatiamides A-F. Angewandte Chemie (International Ed. in English). PMID 31071229 DOI: 10.1002/anie.201902571  0.68
2019 Tayler NM, Boya CA, Herrera L, Moy J, Ng M, Pineda L, Almanza A, Rosero S, Coronado LM, Correa R, Santamaría R, Caballero Z, Durant-Archibold AA, Tidgewell KJ, Balunas MJ, ... Gerwick WH, et al. Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién. Plos One. 14: e0214193. PMID 30939131 DOI: 10.1371/journal.pone.0214193  0.8
2019 Caro-Diaz EJE, Valeriote FA, Gerwick WH. Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp. Organic Letters. PMID 30673235 DOI: 10.1021/acs.orglett.8b04050  0.52
2019 Ong JFM, Goh HC, Lim SC, Pang LM, Chin JSF, Tan KS, Liang ZX, Yang L, Glukhov E, Gerwick WH, Tan LT. Integrated Genomic and Metabolomic Approach to the Discovery of Potential Anti-Quorum Sensing Natural Products from Microbes Associated with Marine Samples from Singapore. Marine Drugs. 17. PMID 30669697 DOI: 10.3390/md17010072  1
2018 Choi H, Engene N, Byrum T, Hwang S, Oh DC, Gerwick WH. Dragocins A-D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium. Organic Letters. PMID 30566359 DOI: 10.1021/acs.orglett.8b03712  1
2018 Ding CYG, Pang LM, Liang ZX, Goh KKK, Glukhov E, Gerwick WH, Tan LT. MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria. Marine Drugs. 16. PMID 30551660 DOI: 10.3390/md16120505  1
2018 Skiba MA, Bivins MM, Schultz JR, Bernard SM, Fiers WD, Dan Q, Kulkarni S, Wipf P, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Structural Basis of Polyketide Synthase O-Methylation. Acs Chemical Biology. PMID 30489068 DOI: 10.1021/acschembio.8b00687  0.44
2018 McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Gerwick WH, et al. Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30468235 DOI: 10.1039/c8np90041h  0.8
2018 Moss NA, Leao T, Rankin M, McCullough TM, Qu P, Korobeynikov A, Smith JL, Gerwick L, Gerwick WH. Ketoreductase domain dysfunction expands chemodiversity: malyngamide biosynthesis in the cyanobacterium Okeania hirsuta. Acs Chemical Biology. PMID 30444349 DOI: 10.1021/acschembio.8b00910  0.68
2018 Almaliti J, Miller B, Pietraszkiewicz H, Glukhov E, Naman CB, Kline T, Hanson J, Li X, Zhou S, Valeriote FA, Gerwick WH. Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents. European Journal of Medicinal Chemistry. 161: 416-432. PMID 30384045 DOI: 10.1016/j.ejmech.2018.10.024  0.56
2018 McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Gerwick WH, et al. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30003207 DOI: 10.1039/c7np00064b  0.8
2018 Huang Q, Chen J, Zhang W, Zhou B, Zhang C, Gerwick WH, Cao Z. Corrigendum to: "Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons" [Phytochemistry (2018) 150 85-92]. Phytochemistry. PMID 29907440 DOI: 10.1016/j.phytochem.2018.06.004  0.56
2018 Moss NA, Leao T, Glukhov E, Gerwick L, Gerwick WH. Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. Methods in Enzymology. 604: 3-43. PMID 29779657 DOI: 10.1016/bs.mie.2018.02.014  0.68
2018 Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. Acs Chemical Biology. PMID 29701944 DOI: 10.1021/acschembio.8b00252  0.68
2018 Wang J, Zheng J, Huang C, Zhao J, Lin J, Zhou X, Naman CB, Wang N, Gerwick WH, Wang Q, Yan X, Cui W, He S. Eckmaxol, a phlorotannin extracted from Ecklonia maxima, produces anti-β-amyloid oligomer neuroprotective effects possibly via directly acting on glycogen synthase kinase 3β. Acs Chemical Neuroscience. PMID 29608860 DOI: 10.1021/acschemneuro.7b00527  0.56
2018 Huang Q, Chen J, Zhang W, Zhou B, Zhang C, Gerwick WH, Cao Z. Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons. Phytochemistry. 150: 85-92. PMID 29571149 DOI: 10.1016/j.phytochem.2018.03.006  0.56
2018 Tao Y, Li P, Zhang D, Glukhov E, Gerwick L, Zhang C, Murray TF, Gerwick WH. The Samholides, Swinholide Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. The Journal of Organic Chemistry. PMID 29457979 DOI: 10.1021/acs.joc.8b00028  0.68
2018 Shao CL, Mou XF, Cao F, Spadafora C, Glukhov E, Gerwick L, Wang CY, Gerwick WH. Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. Journal of Natural Products. PMID 29327931 DOI: 10.1021/acs.jnatprod.7b00917  0.68
2017 Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. Journal of Natural Products. PMID 29215273 DOI: 10.1021/acs.jnatprod.7b00734  0.68
2017 Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. Acs Chemical Biology. PMID 29096064 DOI: 10.1021/acschembio.7b00746  0.68
2017 Zhang C, Idelbayev Y, Roberts N, Tao Y, Nannapaneni Y, Duggan BM, Min J, Lin EC, Gerwick EC, Cottrell GW, Gerwick WH. Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research. Scientific Reports. 7: 14243. PMID 29079836 DOI: 10.1038/s41598-017-13923-x  0.56
2017 Fang F, Zhao J, Ding L, Huang C, Naman CB, He S, Wu B, Zhu P, Luo Q, Gerwick WH, Yan X, Wang Q, Zhang Z, Cui W. 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Marine Drugs. 15. PMID 28825620 DOI: 10.3390/md15080260  0.56
2017 Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH. Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. Journal of Natural Products. PMID 28783331 DOI: 10.1021/acs.jnatprod.7b00367  0.68
2017 Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high. Proceedings of the National Academy of Sciences of the United States of America. PMID 28710331 DOI: 10.1073/pnas.1711139114  0.8
2017 LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, ... Gerwick WH, et al. Development of a potent inhibitor of the Plasmodium proteasome with reduced mammalian toxicity. Journal of Medicinal Chemistry. PMID 28696697 DOI: 10.1021/acs.jmedchem.7b00671  0.68
2017 Almaliti J, Malloy KL, Glukhov E, Spadafora C, Gutiérrez M, Gerwick WH. Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens. Journal of Natural Products. PMID 28535042 DOI: 10.1021/acs.jnatprod.7b00034  0.68
2017 Luzzatto Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick WH, Dorrestein PC. Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife. 6. PMID 28492366 DOI: 10.7554/eLife.24214  0.68
2017 Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Retrospective analysis of natural products provides insights for future discovery trends. Proceedings of the National Academy of Sciences of the United States of America. PMID 28461474 DOI: 10.1073/pnas.1614680114  0.8
2017 Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick WH. A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. Journal of Natural Products. PMID 28448144 DOI: 10.1021/acs.jnatprod.7b00019  0.8
2017 Zhang C, Naman CB, Engene N, Gerwick WH. Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata. Marine Drugs. 15. PMID 28420100 DOI: 10.3390/md15040121  1
2017 Leao T, Castelão G, Korobeynikov A, Monroe EA, Podell S, Glukhov E, Allen EE, Gerwick WH, Gerwick L. Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proceedings of the National Academy of Sciences of the United States of America. PMID 28265051 DOI: 10.1073/pnas.1618556114  0.68
2017 Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, Gerwick WH. Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. Journal of Natural Products. PMID 28055219 DOI: 10.1021/acs.jnatprod.6b00907  0.56
2016 Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP. Corrigendum: Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria. Angewandte Chemie (International Ed. in English). 55: 14895. PMID 27860179 DOI: 10.1002/anie.201609701  0.44
2016 Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase. Acs Chemical Biology. PMID 27723289 DOI: 10.1021/acschembio.6b00759  0.44
2016 Sabry OM, Goeger DE, Gerwick WH. Bioactive new metabolites from the green alga Udotea orientalis growing on the Gorgonian coral Pseudopterogorgia rigida. Natural Product Research. 1-6. PMID 27653761 DOI: 10.1080/14786419.2016.1236096  0.6
2016 Sabry OM, Goeger DE, Valeriote FA, Gerwick WH. Cytotoxic halogenated monoterpenes from Plocamium cartilagineum. Natural Product Research. 1-7. PMID 27627578 DOI: 10.1080/14786419.2016.1230115  0.6
2016 Cummings SL, Barbé D, Leao TF, Korobeynikov A, Engene N, Glukhov E, Gerwick WH, Gerwick L. A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. Bmc Microbiology. 16: 198. PMID 27577966 DOI: 10.1186/s12866-016-0817-1  1
2016 Maloney FP, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573844 DOI: 10.1073/pnas.1607210113  0.68
2016 Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, ... ... Gerwick WH, et al. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology. 34: 828-837. PMID 27504778 DOI: 10.1038/nbt.3597  1
2016 Sabry OM, Goeger DE, Gerwick WH. Biologically active new metabolites from a Florida collection of Moorea producens. Natural Product Research. 1-7. PMID 27426414 DOI: 10.1080/14786419.2016.1207074  0.6
2016 Torres-Mendoza D, González Y, Gómez-Reyes JF, Guzmán HM, López-Perez JL, Gerwick WH, Fernandez PL, Gutiérrez M. Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea. Molecules (Basel, Switzerland). 21. PMID 27338338 DOI: 10.3390/molecules21060819  0.64
2016 Kunz HH, Park J, Mevers E, García AV, Highhouse S, Gerwick WH, Parker JE, Schroeder JI. Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein Mutants. Plos One. 11: e0155937. PMID 27219122 DOI: 10.1371/journal.pone.0155937  1
2016 Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chemical Biology. 23: 561-6. PMID 27203376 DOI: 10.1016/j.chembiol.2016.04.008  1
2016 Briand E, Humbert JF, Tambosco K, Bormans M, Gerwick WH. Role of bacteria in the production and degradation of Microcystis cyanopeptides. Microbiologyopen. PMID 26918405 DOI: 10.1002/mbo3.343  1
2016 O'Rourke A, Kremb S, Bader TM, Helfer M, Schmitt-Kopplin P, Gerwick WH, Brack-Werner R, Voolstra CR. Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1). Marine Drugs. 14. PMID 26861355 DOI: 10.3390/md14020028  1
2016 Fenner AM, Engene N, Spadafora C, Gerwick WH, Balunas MJ. Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids. Organic Letters. PMID 26784681 DOI: 10.1021/acs.orglett.5b03110  1
2016 Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH. The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem : a European Journal of Chemical Biology. 17: 164-73. PMID 26769357 DOI: 10.1002/cbic.201500467  1
2016 Kleigrewe K, Gerwick L, Sherman DH, Gerwick WH. Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Natural Product Reports. PMID 26758451 DOI: 10.1039/c5np00097a  1
2015 Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, Gerwick WH. Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities. Phytochemistry. PMID 26632528 DOI: 10.1016/j.phytochem.2015.11.011  1
2015 Moss NA, Bertin MJ, Kleigrewe K, Leão TF, Gerwick L, Gerwick WH. Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. Journal of Industrial Microbiology & Biotechnology. PMID 26578313 DOI: 10.1007/s10295-015-1705-7  1
2015 Teta R, Della Sala G, Glukhov E, Gerwick L, Gerwick WH, Mangoni A, Costantino V. A combined LC-MS/MS and molecular networking approach reveals new cyanotoxins from the 2014 cyanobacterial bloom in Green Lake, Seattle. Environmental Science & Technology. PMID 26567695 DOI: 10.1021/acs.est.5b04415  1
2015 Sapkota M, Li L, Choi H, Gerwick WH, Soh Y. Bromo-Honaucin A inhibits osteoclastogenic differentiation in RAW 264.7 cells via Akt and ERK signaling pathways. European Journal of Pharmacology. PMID 26550952 DOI: 10.1016/j.ejphar.2015.11.003  1
2015 Khare D, Hale WA, Tripathi A, Gu L, Sherman DH, Gerwick WH, Håkansson K, Smith JL. Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure (London, England : 1993). PMID 26526850 DOI: 10.1016/j.str.2015.09.013  1
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Gerwick WH, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/nchembio.1890  1
2015 Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP. Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria. Angewandte Chemie (International Ed. in English). PMID 26235728 DOI: 10.1002/anie.201503186  1
2015 Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. Plos One. 10: e0133297. PMID 26222584 DOI: 10.1371/journal.pone.0133297  1
2015 Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. The Journal of Organic Chemistry. PMID 26222145 DOI: 10.1021/acs.joc.5b01264  1
2015 Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. Journal of Natural Products. PMID 26149623 DOI: 10.1021/acs.jnatprod.5b00301  1
2015 Briand E, Bormans M, Gugger M, Dorrestein PC, Gerwick WH. Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions. Environmental Microbiology. PMID 25980449 DOI: 10.1111/1462-2920.12904  1
2015 Moore BS, Gerwick WH. Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. Journal of Natural Products. 78: 347-8. PMID 25814030 DOI: 10.1021/acs.jnatprod.5b00146  1
2015 Morgan JB, Liu Y, Coothankandaswamy V, Mahdi F, Jekabsons MB, Gerwick WH, Valeriote FA, Zhou YD, Nagle DG. Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells. Marine Drugs. 13: 1552-68. PMID 25803180 DOI: 10.3390/md13031552  1
2015 Rho JR, Subramaniam G, Choi H, Kim EH, Ng SP, Yoganathan K, Ng S, Buss AD, Butler MS, Gerwick WH. Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp. Organic Letters. 17: 1377-80. PMID 25723256 DOI: 10.1021/acs.orglett.5b00068  1
2015 Cao Z, Li X, Zou X, Greenwood M, Gerwick WH, Murray TF. Involvement of JNK and caspase activation in hoiamide A-induced neurotoxicity in neocortical neurons. Marine Drugs. 13: 903-19. PMID 25675001 DOI: 10.3390/md13020903  1
2015 Bertin MJ, Schwartz SL, Lee J, Korobeynikov A, Dorrestein PC, Gerwick L, Gerwick WH. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. Journal of Natural Products. 78: 493-9. PMID 25668560 DOI: 10.1021/np5009762  1
2015 Vining OB, Medina RA, Mitchell EA, Videau P, Li D, Serrill JD, Kelly JX, Gerwick WH, Proteau PJ, Ishmael JE, McPhail KL. Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer. Journal of Natural Products. 78: 413-20. PMID 25562664 DOI: 10.1021/np5007907  1
2015 Brito Â, Gaifem J, Ramos V, Glukhov E, Dorrestein PC, Gerwick WH, Vasconcelos VM, Mendes MV, Tamagnini P. Bioprospecting Portuguese Atlantic coast cyanobacteria for bioactive secondary metabolites reveals untapped chemodiversity Algal Research. 9: 218-226. DOI: 10.1016/j.algal.2015.03.016  1
2014 Mehrotra S, Duggan BM, Tello-Aburto R, Newar TD, Gerwick WH, Murray TF, Maio WA. Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists. Journal of Natural Products. 77: 2553-60. PMID 25343669 DOI: 10.1021/np500644k  1
2014 Vogel CV, Pietraszkiewicz H, Sabry OM, Gerwick WH, Valeriote FA, Vanderwal CD. Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors. Angewandte Chemie (International Ed. in English). 53: 12205-9. PMID 25220828 DOI: 10.1002/anie.201407726  1
2014 Mevers E, Matainaho T, Allara' M, Di Marzo V, Gerwick WH. Mooreamide A: a cannabinomimetic lipid from the marine cyanobacterium Moorea bouillonii. Lipids. 49: 1127-32. PMID 25204580 DOI: 10.1007/s11745-014-3949-9  1
2014 Moree WJ, McConnell OJ, Nguyen DD, Sanchez LM, Yang YL, Zhao X, Liu WT, Boudreau PD, Srinivasan J, Atencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, Gerwick WH, et al. Microbiota of healthy corals are active against fungi in a light-dependent manner. Acs Chemical Biology. 9: 2300-8. PMID 25058318 DOI: 10.1021/cb500432j  1
2014 Trivella DB, Pereira AR, Stein ML, Kasai Y, Byrum T, Valeriote FA, Tantillo DJ, Groll M, Gerwick WH, Moore BS. Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chemistry & Biology. 21: 782-91. PMID 24930969 DOI: 10.1016/j.chembiol.2014.04.010  1
2014 Xu DX, Sun P, Kurtán T, Mándi A, Tang H, Liu B, Gerwick WH, Wang ZW, Zhang W. Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. Journal of Natural Products. 77: 1179-84. PMID 24749951 DOI: 10.1021/np500024r  1
2014 Gong J, Sun P, Jiang N, Riccio R, Lauro G, Bifulco G, Li TJ, Gerwick WH, Zhang W. New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei. Organic Letters. 16: 2224-7. PMID 24694058 DOI: 10.1021/ol5007345  1
2014 Almeida C, Ortega H, Higginbotham S, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L. Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass. Letters in Applied Microbiology. 59: 58-64. PMID 24612068 DOI: 10.1111/lam.12245  1
2014 Mevers E, Haeckl FP, Boudreau PD, Byrum T, Dorrestein PC, Valeriote FA, Gerwick WH. Lipopeptides from the tropical marine cyanobacterium Symploca sp. Journal of Natural Products. 77: 969-75. PMID 24588245 DOI: 10.1021/np401051z  1
2014 Coates RC, Podell S, Korobeynikov A, Lapidus A, Pevzner P, Sherman DH, Allen EE, Gerwick L, Gerwick WH. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. Plos One. 9: e85140. PMID 24475038 DOI: 10.1371/journal.pone.0085140  1
2014 Zhou W, Li J, E HC, Liu BS, Tang H, Gerwick WH, Hua HM, Zhang W. Briarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea. Marine Drugs. 12: 589-600. PMID 24473165 DOI: 10.3390/md12020589  1
2014 Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick WH. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. Journal of Natural Products. 77: 92-9. PMID 24364476 DOI: 10.1021/np400727r  0.52
2014 Carneiro VM, Avila CM, Balunas MJ, Gerwick WH, Pilli RA. Coibacins A and B: total synthesis and stereochemical revision. The Journal of Organic Chemistry. 79: 630-42. PMID 24359482 DOI: 10.1021/jo402339y  1
2014 Winnikoff JR, Glukhov E, Watrous J, Dorrestein PC, Gerwick WH. Quantitative molecular networking to profile marine cyanobacterial metabolomes. The Journal of Antibiotics. 67: 105-12. PMID 24281659 DOI: 10.1038/ja.2013.120  1
2014 Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan BM, Moore BS, Gerwick WH, Linington RG, Pogliano K, Dorrestein PC. MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. The Journal of Antibiotics. 67: 99-104. PMID 24149839 DOI: 10.1038/ja.2013.99  1
2014 Fenner AM, Gerwick WH. Marine Bioprospecting Natural Products: Discourse, Diversity, and Design. 83-101. DOI: 10.1002/9781118794623.ch5  1
2013 Engene N, Paul VJ, Byrum T, Gerwick WH, Thor A, Ellisman MH. Five chemically rich species of tropical marine cyanobacteria of the genus Okeania gen. nov. (Oscillatoriales, Cyanoprokaryota). Journal of Phycology. 49: 1095-1106. PMID 27007630 DOI: 10.1111/jpy.12115  1
2013 Della Sala G, Hochmuth T, Costantino V, Teta R, Gerwick W, Gerwick L, Piel J, Mangoni A. Polyketide genes in the marine sponge Plakortis simplex: A new group of mono-modular type I polyketide synthases from sponge symbionts Environmental Microbiology Reports. 5: 809-818. PMID 24249289 DOI: 10.1111/1758-2229.12081  1
2013 Trentacoste EM, Shrestha RP, Smith SR, Glé C, Hartmann AC, Hildebrand M, Gerwick WH. Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proceedings of the National Academy of Sciences of the United States of America. 110: 19748-53. PMID 24248374 DOI: 10.1073/pnas.1309299110  1
2013 Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chemistry & Biology. 20: 1340-51. PMID 24183970 DOI: 10.1016/j.chembiol.2013.09.015  1
2013 Pavlik CM, Wong CY, Ononye S, Lopez DD, Engene N, McPhail KL, Gerwick WH, Balunas MJ. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. Journal of Natural Products. 76: 2026-33. PMID 24164245 DOI: 10.1021/np400198r  1
2013 Mevers E, Byrum T, Gerwick WH. Parguerene and precarriebowmide, two classes of lipopeptides from the marine cyanobacterium Moorea producens. Journal of Natural Products. 76: 1810-4. PMID 24044577 DOI: 10.1021/np400347f  1
2013 Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick WH, et al. Molecular networking as a dereplication strategy. Journal of Natural Products. 76: 1686-99. PMID 24025162 DOI: 10.1021/np400413s  1
2013 Tan LT, Okino T, Gerwick WH. Bouillonamide: a mixed polyketide-peptide cytotoxin from the marine cyanobacterium Moorea bouillonii. Marine Drugs. 11: 3015-24. PMID 23966034 DOI: 10.3390/md11083015  1
2013 Leão PN, Costa M, Ramos V, Pereira AR, Fernandes VC, Domingues VF, Gerwick WH, Vasconcelos VM, Martins R. Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found in both filamentous and unicellular marine strains. Plos One. 8: e69562. PMID 23922738 DOI: 10.1371/journal.pone.0069562  1
2013 Ongley SE, Bian X, Zhang Y, Chau R, Gerwick WH, Müller R, Neilan BA. High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium. Acs Chemical Biology. 8: 1888-93. PMID 23751865 DOI: 10.1021/cb400189j  1
2013 Leão PN, Ramos V, Gonçalves PB, Viana F, Lage OM, Gerwick WH, Vasconcelos VM. Chemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria. Marine Drugs. 11: 1316-35. PMID 23609580 DOI: 10.3390/md11041316  1
2013 Ortega HE, Graupner PR, Asai Y, Tendyke K, Qiu D, Shen YY, Rios N, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L. Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194. Journal of Natural Products. 76: 741-4. PMID 23560689 DOI: 10.1021/np300792t  1
2013 Engene N, Gunasekera SP, Gerwick WH, Paul VJ. Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria. Applied and Environmental Microbiology. 79: 1882-8. PMID 23315747 DOI: 10.1128/AEM.03793-12  1
2013 Gerwick WH, Fenner AM. Drug discovery from marine microbes. Microbial Ecology. 65: 800-6. PMID 23274881 DOI: 10.1007/s00248-012-0169-9  1
2013 Engene N, Paul VJ, Byrum T, Gerwick WH, Thor A, Ellisman MH. Five chemically rich species of tropical marine cyanobacteria of the genus Okeania gen. nov. (Oscillatoriales, Cyanoprokaryota) Journal of Phycology. 49: 1095-1106. DOI: 10.1111/jpy.12115  1
2013 Gerwick L, Boudreau P, Choi H, Mascuch S, Villa FA, Balunas MJ, Malloy KL, Teasdale ME, Rowley DC, Gerwick WH. Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites Phytochemistry Reviews. 12: 459-465. DOI: 10.1007/s11101-012-9237-5  1
2013 Coates RC, Trentacoste E, Gerwick WH. Bioactive and Novel Chemicals from Microalgae Handbook of Microalgal Culture: Applied Phycology and Biotechnology. 504-531. DOI: 10.1002/9781118567166.ch26  1
2012 Molinar E, Rios N, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L. Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus. Tetrahedron Letters. 53: 919-922. PMID 25177062 DOI: 10.1016/j.tetlet.2011.12.021  1
2012 Choi H, Mevers E, Byrum T, Valeriote FA, Gerwick WH. Lyngbyabellins K-N from Two Palmyra Atoll Collections of the Marine Cyanobacterium Moorea bouillonii. European Journal of Organic Chemistry. 2012: 5141-5150. PMID 24574859 DOI: 10.1002/ejoc.201200691  1
2012 George J, Baden DG, Gerwick WH, Murray TF. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity. Proceedings of the National Academy of Sciences of the United States of America. 109: 19840-5. PMID 23150561 DOI: 10.1073/pnas.1212584109  1
2012 Kim EJ, Lee JH, Choi H, Pereira AR, Ban YH, Yoo YJ, Kim E, Park JW, Sherman DH, Gerwick WH, Yoon YJ. Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product. Organic Letters. 14: 5824-7. PMID 23148802 DOI: 10.1021/ol302575h  1
2012 McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. Acs Chemical Biology. 7: 1994-2003. PMID 22991895 DOI: 10.1021/cb300385m  1
2012 Boudreau PD, Byrum T, Liu WT, Dorrestein PC, Gerwick WH. Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. Journal of Natural Products. 75: 1560-70. PMID 22924493 DOI: 10.1021/np300321b  1
2012 Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH. Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Organic Letters. 14: 3878-81. PMID 22794317 DOI: 10.1021/ol301607q  1
2012 Varughese T, Riosa N, Higginbotham S, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla Rios L. Antifungal Depsidone Metabolites from Cordyceps dipterigena, an Endophytic Fungus Antagonistic to the Phytopathogen Gibberella fujikuroi. Tetrahedron Letters. 53: 1624-1626. PMID 22707798 DOI: 10.1016/j.tetlet.2012.01.076  1
2012 Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick WH, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, et al. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. Journal of Proteomics. 75: 5069-76. PMID 22641157 DOI: 10.1016/j.jprot.2012.05.036  1
2012 Choi H, Mascuch SJ, Villa FA, Byrum T, Teasdale ME, Smith JE, Preskitt LB, Rowley DC, Gerwick L, Gerwick WH. Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chemistry & Biology. 19: 589-98. PMID 22633410 DOI: 10.1016/j.chembiol.2012.03.014  1
2012 Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH. Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. The Journal of Organic Chemistry. 77: 4198-208. PMID 22489775 DOI: 10.1021/jo300160e  1
2012 Martínez-Luis S, Cherigo L, Arnold E, Spadafora C, Gerwick WH, Cubilla-Rios L. Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544. Natural Product Communications. 7: 165-8. PMID 22474943  1
2012 Charusanti P, Fong NL, Nagarajan H, Pereira AR, Li HJ, Abate EA, Su Y, Gerwick WH, Palsson BO. Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. Plos One. 7: e33727. PMID 22470465 DOI: 10.1371/journal.pone.0033727  1
2012 Pereira AR, Kale AJ, Fenley AT, Byrum T, Debonsi HM, Gilson MK, Valeriote FA, Moore BS, Gerwick WH. The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. Chembiochem : a European Journal of Chemical Biology. 13: 810-7. PMID 22383253 DOI: 10.1002/cbic.201200007  0.8
2012 Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore BS, Gerwick WH. Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. The Febs Journal. 279: 1243-51. PMID 22314229 DOI: 10.1111/j.1742-4658.2012.08517.x  1
2012 Gerwick WH, Moore BS. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chemistry & Biology. 19: 85-98. PMID 22284357 DOI: 10.1016/j.chembiol.2011.12.014  1
2012 Leão PN, Engene N, Antunes A, Gerwick WH, Vasconcelos V. The chemical ecology of cyanobacteria. Natural Product Reports. 29: 372-91. PMID 22237837 DOI: 10.1039/c2np00075j  1
2012 Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick WH. Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. Journal of Natural Products. 75: 60-6. PMID 22148360 DOI: 10.1021/np200611f  1
2012 Gehret JJ, Gu L, Geders TW, Brown WC, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Science : a Publication of the Protein Society. 21: 239-48. PMID 22124946 DOI: 10.1002/pro.2009  1
2012 Malloy KL, Choi H, Fiorilla C, Valeriote FA, Matainaho T, Gerwick WH. Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction. Bioorganic & Medicinal Chemistry Letters. 22: 683-8. PMID 22104152 DOI: 10.1016/j.bmcl.2011.10.054  1
2012 Choi H, Proteau PJ, Byrum T, Pereira AR, Gerwick WH. Cymatherelactone and cymatherols A-C, polycyclic oxylipins from the marine brown alga Cymathere triplicata. Phytochemistry. 73: 134-41. PMID 22071135 DOI: 10.1016/j.phytochem.2011.09.014  1
2012 Engene N, Rottacker EC, KaÅ¡tovský J, Byrum T, Choi H, Ellisman MH, Komárek J, Gerwick WH. Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites. International Journal of Systematic and Evolutionary Microbiology. 62: 1171-8. PMID 21724952 DOI: 10.1099/ijs.0.033761-0  1
2012 González-Davis O, Ponce-Rivas E, Sánchez-Saavedra MDP, Muñoz-Márquez ME, Gerwick WH. Bioprospection of Microalgae and Cyanobacteria as Biocontrol Agents Against Vibrio campbellii and Their Use in White Shrimp Litopenaeus vannamei Culture Journal of the World Aquaculture Society. 43: 387-399. DOI: 10.1111/j.1749-7345.2012.00567.x  1
2011 Martínez-Luis S, Cherigo L, Higginbotham S, Arnold E, Spadafora C, Ibañez A, Gerwick WH, Cubilla-Rios L. Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi. International Microbiology : the Official Journal of the Spanish Society For Microbiology. 14: 95-102. PMID 22069153 DOI: 10.2436/20.1501.01.139  1
2011 Gutiérrez M, Pereira AR, Debonsi HM, Ligresti A, Di Marzo V, Gerwick WH. Cannabinomimetic lipid from a marine cyanobacterium. Journal of Natural Products. 74: 2313-7. PMID 21999614 DOI: 10.1021/np200610t  1
2011 Han B, Gross H, McPhail KL, Goeger D, Maier CS, Gerwick WH. Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula. Journal of Microbiology and Biotechnology. 21: 930-6. PMID 21952369 DOI: 10.4014/jmb.1105.05011  1
2011 Moreno E, Varughese T, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L. Chemical constituents of the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity. Natural Product Communications. 6: 835-40. PMID 21815421  1
2011 Esquenazi E, Daly M, Bahrainwala T, Gerwick WH, Dorrestein PC. Ion mobility mass spectrometry enables the efficient detection and identification of halogenated natural products from cyanobacteria with minimal sample preparation. Bioorganic & Medicinal Chemistry. 19: 6639-44. PMID 21784647 DOI: 10.1016/j.bmc.2011.06.081  1
2011 Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH. Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products. 74: 1737-43. PMID 21751786 DOI: 10.1021/np200236c  1
2011 Jones CS, Esquenazi E, Dorrestein PC, Gerwick WH. Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry. Bioorganic & Medicinal Chemistry. 19: 6620-7. PMID 21742508 DOI: 10.1016/j.bmc.2011.06.005  1
2011 Suyama TL, Gerwick WH, McPhail KL. Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis. Bioorganic & Medicinal Chemistry. 19: 6675-701. PMID 21715178 DOI: 10.1016/j.bmc.2011.06.011  1
2011 Nunnery JK, Suyama TL, Linington RG, Gerwick WH. Expedient synthesis of α,α-dimethyl-β-hydroxy carbonyl scaffolds via Evans' aldol reaction with a tertiary enolate. Tetrahedron Letters. 52: 2929-2932. PMID 21617761 DOI: 10.1016/j.tetlet.2011.03.126  1
2011 Jones AC, Monroe EA, Podell S, Hess WR, Klages S, Esquenazi E, Niessen S, Hoover H, Rothmann M, Lasken RS, Yates JR, Reinhardt R, Kube M, Burkart MD, Allen EE, ... ... Gerwick WH, et al. Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proceedings of the National Academy of Sciences of the United States of America. 108: 8815-20. PMID 21555588 DOI: 10.1073/pnas.1101137108  1
2011 Grindberg RV, Ishoey T, Brinza D, Esquenazi E, Coates RC, Liu WT, Gerwick L, Dorrestein PC, Pevzner P, Lasken R, Gerwick WH. Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. Plos One. 6: e18565. PMID 21533272 DOI: 10.1371/journal.pone.0018565  1
2011 Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, et al. Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology. 77: 3617-25. PMID 21498757 DOI: 10.1128/AEM.00038-11  1
2011 Mevers E, Liu WT, Engene N, Mohimani H, Byrum T, Pevzner PA, Dorrestein PC, Spadafora C, Gerwick WH. Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products. 74: 928-36. PMID 21488639 DOI: 10.1021/np200077f  1
2011 Engene N, Choi H, Esquenazi E, Rottacker EC, Ellisman MH, Dorrestein PC, Gerwick WH. Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environmental Microbiology. 13: 1601-10. PMID 21477107 DOI: 10.1111/j.1462-2920.2011.02472.x  1
2011 Pereira AR, Etzbach L, Engene N, Müller R, Gerwick WH. Molluscicidal metabolites from an assemblage of Palmyra Atoll cyanobacteria. Journal of Natural Products. 74: 1175-81. PMID 21473610 DOI: 10.1021/np200106b  1
2011 Han B, Reinscheid UM, Gerwick WH, Gross H. The structure elucidation of isomalyngamide K from the marine cyanobacterium Lyngbya majuscula by experimental and DFT computational methods. Journal of Molecular Structure. 989: 109-113. PMID 21461120 DOI: 10.1016/j.molstruc.2011.01.012  1
2011 Jones AC, Monroe EA, Gerwick WH. Elegant metabolite biosynthesis. Chemistry & Biology. 18: 281-3. PMID 21439471 DOI: 10.1016/j.chembiol.2011.03.001  1
2011 Esquenazi E, Jones AC, Byrum T, Dorrestein PC, Gerwick WH. Temporal dynamics of natural product biosynthesis in marine cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America. 108: 5226-31. PMID 21393570 DOI: 10.1073/pnas.1012813108  1
2011 Gu L, Eisman EB, Dutta S, Franzmann TM, Walter S, Gerwick WH, Skiniotis G, Sherman DH. Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angewandte Chemie (International Ed. in English). 50: 2795-8. PMID 21387490 DOI: 10.1002/anie.201005280  1
2011 Gehret JJ, Gu L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. The Journal of Biological Chemistry. 286: 14445-54. PMID 21357626 DOI: 10.1074/jbc.M110.214635  1
2011 Malloy KL, Villa FA, Engene N, Matainaho T, Gerwick L, Gerwick WH. Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium. Journal of Natural Products. 74: 95-8. PMID 21155594 DOI: 10.1021/np1005407  1
2011 Engene N, Gerwick WH. Intra-genomic 16S rRNA gene heterogeneity in cyanobacterial genomes Fottea. 11: 17-24.  1
2010 Cao Z, Gerwick WH, Murray TF. Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits. Bmc Neuroscience. 11: 154. PMID 21156065 DOI: 10.1186/1471-2202-11-154  1
2010 Nunnery JK, Mevers E, Gerwick WH. Biologically active secondary metabolites from marine cyanobacteria. Current Opinion in Biotechnology. 21: 787-93. PMID 21030245 DOI: 10.1016/j.copbio.2010.09.019  1
2010 Pereira AR, Cao Z, Engene N, Soria-Mercado IE, Murray TF, Gerwick WH. Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria. Organic Letters. 12: 4490-3. PMID 20845912 DOI: 10.1021/ol101752n  1
2010 Gross H, McPhail KL, Goeger DE, Valeriote FA, Gerwick WH. Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula. Phytochemistry. 71: 1729-35. PMID 20701935 DOI: 10.1016/j.phytochem.2010.07.001  1
2010 Choi H, Pereira AR, Cao Z, Shuman CF, Engene N, Byrum T, Matainaho T, Murray TF, Mangoni A, Gerwick WH. The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria. Journal of Natural Products. 73: 1411-21. PMID 20687534 DOI: 10.1021/np100468n  1
2010 Khare D, Wang B, Gu L, Razelun J, Sherman DH, Gerwick WH, HÃ¥kansson K, Smith JL. Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 14099-104. PMID 20660778 DOI: 10.1073/pnas.1006738107  1
2010 Leão PN, Pereira AR, Liu WT, Ng J, Pevzner PA, Dorrestein PC, König GM, Vasconcelos VM, Gerwick WH. Synergistic allelochemicals from a freshwater cyanobacterium. Proceedings of the National Academy of Sciences of the United States of America. 107: 11183-8. PMID 20534563 DOI: 10.1073/pnas.0914343107  1
2010 Tidgewell K, Engene N, Byrum T, Media J, Doi T, Valeriote FA, Gerwick WH. Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouillonii. Chembiochem : a European Journal of Chemical Biology. 11: 1458-66. PMID 20512792 DOI: 10.1002/cbic.201000070  1
2010 Jones AC, Monroe EA, Eisman EB, Gerwick L, Sherman DH, Gerwick WH. The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Natural Product Reports. 27: 1048-65. PMID 20442916 DOI: 10.1039/c000535e  1
2010 Sanchez LM, Lopez D, Vesely BA, Della Togna G, Gerwick WH, Kyle DE, Linington RG. Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. Journal of Medicinal Chemistry. 53: 4187-97. PMID 20441198 DOI: 10.1021/jm100265s  1
2010 Choi H, Engene N, Smith JE, Preskitt LB, Gerwick WH. Crossbyanols A-D, toxic brominated polyphenyl ethers from the Hawai'ian bloom-forming Cyanobacterium Leptolyngbya crossbyana. Journal of Natural Products. 73: 517-22. PMID 20170122 DOI: 10.1021/np900661g  1
2010 Gutiérrez M, Tidgewell K, Capson TL, Engene N, Almanza A, Schemies J, Jung M, Gerwick WH. Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 73: 709-11. PMID 20158242 DOI: 10.1021/np9005184  1
2010 Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure (London, England : 1993). 18: 94-105. PMID 20152156 DOI: 10.1016/j.str.2009.10.018  1
2010 Bedke DK, Shibuya GM, Pereira AR, Gerwick WH, Vanderwal CD. A concise enantioselective synthesis of the chlorosulfolipid malhamensilipin A. Journal of the American Chemical Society. 132: 2542-3. PMID 20141139 DOI: 10.1021/ja910809c  1
2010 Pereira AR, McCue CF, Gerwick WH. Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii. Journal of Natural Products. 73: 217-20. PMID 20131814 DOI: 10.1021/np9008128  1
2010 Pereira AR, Byrum T, Shibuya GM, Vanderwal CD, Gerwick WH. Structure revision and absolute configuration of malhamensilipin A from the freshwater chrysophyte Poterioochromonas malhamensis. Journal of Natural Products. 73: 279-83. PMID 20099812 DOI: 10.1021/np900672h  1
2010 Balunas MJ, Linington RG, Tidgewell K, Fenner AM, Ureña LD, Togna GD, Kyle DE, Gerwick WH. Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. Journal of Natural Products. 73: 60-6. PMID 20030365 DOI: 10.1021/np900622m  1
2010 Jabba SV, Prakash A, Dravid SM, Gerwick WH, Murray TF. Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. The Journal of Pharmacology and Experimental Therapeutics. 332: 698-709. PMID 20026674 DOI: 10.1124/jpet.109.161802  1
2010 Huynh MU, Elston MC, Hernandez NM, Ball DB, Kajiyama S, Irie K, Gerwick WH, Edwards DJ. Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase. Journal of Natural Products. 73: 71-4. PMID 20000453 DOI: 10.1021/np900481a  1
2010 Taniguchi M, Nunnery JK, Engene N, Esquenazi E, Byrum T, Dorrestein PC, Gerwick WH. Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 73: 393-8. PMID 19839606 DOI: 10.1021/np900428h  1
2010 Suyama TL, Cao Z, Murray TF, Gerwick WH. Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: structure clarification and biological properties. Toxicon : Official Journal of the International Society On Toxinology. 55: 204-10. PMID 19638282 DOI: 10.1016/j.toxicon.2009.07.020  1
2010 Engene N, Cameron Coates R, Gerwick WH. 16S Rrna gene heterogeneity in the filamentous marine cyanobacterial genus lyngbya Journal of Phycology. 46: 591-601. DOI: 10.1111/j.1529-8817.2010.00840.x  1
2010 Tidgewell K, Clark BR, Gerwick WH. The natural products chemistry of cyanobacteria Comprehensive Natural Products Ii: Chemistry and Biology. 2: 141-188.  1
2009 Jones AC, Gerwick L, Gonzalez D, Dorrestein PC, Gerwick WH. Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. Bmc Microbiology. 9: 247. PMID 19951434 DOI: 10.1186/1471-2180-9-247  1
2009 Esquenazi E, Yang YL, Watrous J, Gerwick WH, Dorrestein PC. Imaging mass spectrometry of natural products. Natural Product Reports. 26: 1521-34. PMID 19936384 DOI: 10.1039/b915674g  1
2009 Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, HÃ¥kansson K, Smith JL, Sherman DH. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society. 131: 16033-5. PMID 19835378 DOI: 10.1021/ja9071578  1
2009 Soria-Mercado IE, Pereira A, Cao Z, Murray TF, Gerwick WH. Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. Organic Letters. 11: 4704-7. PMID 19754100 DOI: 10.1021/ol901438b  1
2009 Pereira A, Cao Z, Murray TF, Gerwick WH. Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria. Chemistry & Biology. 16: 893-906. PMID 19716479 DOI: 10.1016/j.chembiol.2009.06.012  1
2009 Ng J, Bandeira N, Liu WT, Ghassemian M, Simmons TL, Gerwick WH, Linington R, Dorrestein PC, Pevzner PA. Dereplication and de novo sequencing of nonribosomal peptides. Nature Methods. 6: 596-9. PMID 19597502 DOI: 10.1038/nmeth.1350  1
2009 Gutiérrez M, Andrianasolo EH, Shin WK, Goeger DE, Yokochi A, Schemies J, Jung M, France D, Cornell-Kennon S, Lee E, Gerwick WH. Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. The Journal of Organic Chemistry. 74: 5267-75. PMID 19572575 DOI: 10.1021/jo900578j  1
2009 Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, HÃ¥kansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH. Metamorphic enzyme assembly in polyketide diversification. Nature. 459: 731-5. PMID 19494914 DOI: 10.1038/nature07870  1
2009 Simmons TL, Nogle LM, Media J, Valeriote FA, Mooberry SL, Gerwick WH. Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms. Journal of Natural Products. 72: 1011-6. PMID 19489598 DOI: 10.1021/np9001674  1
2009 Sorrels CM, Proteau PJ, Gerwick WH. Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment. Applied and Environmental Microbiology. 75: 4861-9. PMID 19482954 DOI: 10.1128/AEM.02508-08  1
2009 Bedke DK, Shibuya GM, Pereira A, Gerwick WH, Haines TH, Vanderwal CD. Relative stereochemistry determination and synthesis of the major chlorosulfolipid from Ochromonas danica. Journal of the American Chemical Society. 131: 7570-2. PMID 19445461 DOI: 10.1021/ja902138w  1
2009 Esquenazi E, Dorrestein PC, Gerwick WH. Probing marine natural product defenses with DESI-imaging mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 106: 7269-70. PMID 19416917 DOI: 10.1073/pnas.0902840106  1
2009 Liu WT, Ng J, Meluzzi D, Bandeira N, Gutierrez M, Simmons TL, Schultz AW, Linington RG, Moore BS, Gerwick WH, Pevzner PA, Dorrestein PC. Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Analytical Chemistry. 81: 4200-9. PMID 19413302 DOI: 10.1021/ac900114t  1
2009 Jones AC, Gu L, Sorrels CM, Sherman DH, Gerwick WH. New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Current Opinion in Chemical Biology. 13: 216-23. PMID 19307147 DOI: 10.1016/j.cbpa.2009.02.019  1
2009 Linington RG, Clark BR, Trimble EE, Almanza A, Ureña LD, Kyle DE, Gerwick WH. Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. Journal of Natural Products. 72: 14-7. PMID 19161344 DOI: 10.1021/np8003529  1
2009 Pereira A, Cao Z, Murray TF, Gerwick WH. Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria (DOI:10.1016/j.chembiol.2009.06.012) Chemistry and Biology. 16: 1208. DOI: 10.1016/j.chembiol.2009.11.007  1
2008 Martínez-Luis S, Della-Togna G, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L. Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp. Journal of Natural Products. 71: 2011-4. PMID 19007286 DOI: 10.1021/np800472q  1
2008 Suyama TL, Gerwick WH. Stereospecific total synthesis of somocystinamide A. Organic Letters. 10: 4449-52. PMID 18788741 DOI: 10.1021/ol8016947  1
2008 Simmons TL, Engene N, Ureña LD, Romero LI, Ortega-Barría E, Gerwick L, Gerwick WH. Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. Journal of Natural Products. 71: 1544-50. PMID 18715036 DOI: 10.1021/np800110e  1
2008 Clark BR, Engene N, Teasdale ME, Rowley DC, Matainaho T, Valeriote FA, Gerwick WH. Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. Journal of Natural Products. 71: 1530-7. PMID 18698821 DOI: 10.1021/np800088a  1
2008 Esquenazi E, Coates C, Simmons L, Gonzalez D, Gerwick WH, Dorrestein PC. Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Molecular Biosystems. 4: 562-70. PMID 18493654 DOI: 10.1039/b720018h  1
2008 Cao Z, George J, Gerwick WH, Baden DG, Rainier JD, Murray TF. Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons. The Journal of Pharmacology and Experimental Therapeutics. 326: 604-13. PMID 18448863 DOI: 10.1124/jpet.108.138230  1
2008 Gutiérrez M, Suyama TL, Engene N, Wingerd JS, Matainaho T, Gerwick WH. Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. Journal of Natural Products. 71: 1099-103. PMID 18444683 DOI: 10.1021/np800121a  1
2008 Medina RA, Goeger DE, Hills P, Mooberry SL, Huang N, Romero LI, Ortega-Barría E, Gerwick WH, McPhail KL. Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp. Journal of the American Chemical Society. 130: 6324-5. PMID 18444611 DOI: 10.1021/ja801383f  1
2008 Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proceedings of the National Academy of Sciences of the United States of America. 105: 2313-8. PMID 18268346 DOI: 10.1073/pnas.0712198105  1
2008 Simmons TL, Coates RC, Clark BR, Engene N, Gonzalez D, Esquenazi E, Dorrestein PC, Gerwick WH. Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages. Proceedings of the National Academy of Sciences of the United States of America. 105: 4587-94. PMID 18250337 DOI: 10.1073/pnas.0709851105  1
2008 Linington RG, Edwards DJ, Shuman CF, McPhail KL, Matainaho T, Gerwick WH. Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp. Journal of Natural Products. 71: 22-7. PMID 18163584 DOI: 10.1021/np070280x  1
2008 Gerwick WH, Coates RC, Engene N, Gerwick L, Grindberg RV, Jones AC, Sorrels CM. Giant marine cyanobacteria produce exciting potential pharmaceuticals Microbe. 3: 277-284.  1
2007 Ramaswamy AV, Sorrels CM, Gerwick WH. Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 70: 1977-86. PMID 18001088 DOI: 10.1021/np0704250  1
2007 Gu L, Geders TW, Wang B, Gerwick WH, Håkansson K, Smith JL, Sherman DH. GNAT-like strategy for polyketide chain initiation. Science (New York, N.Y.). 318: 970-4. PMID 17991863 DOI: 10.1126/science.1148790  1
2007 Kourtchenko O, Andersson MX, Hamberg M, Brunnström A, Göbel C, McPhail KL, Gerwick WH, Feussner I, Ellerström M. Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: jasmonate signaling dependence. Plant Physiology. 145: 1658-69. PMID 17951463 DOI: 10.1104/pp.107.104752  1
2007 Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Håkansson K, Sherman DH, Smith JL. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. The Journal of Biological Chemistry. 282: 35954-63. PMID 17928301 DOI: 10.1074/jbc.M703921200  1
2007 Jiménez-Romero C, Torres-Mendoza D, Ureña González LD, Ortega-Barría E, McPhail KL, Gerwick WH, Cubilla-Rios L. Hydroxyalkenylresorcinols from Stylogyne turbacensis. Journal of Natural Products. 70: 1249-52. PMID 17629327 DOI: 10.1021/np070081d  1
2007 McPhail KL, Correa J, Linington RG, Gonzalez J, Ortega-Barría E, Capson TL, Gerwick WH. Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 70: 984-8. PMID 17441769 DOI: 10.1021/np0700772  1
2007 Linington RG, Gonzalez J, Ureña LD, Romero LI, Ortega-Barría E, Gerwick WH. Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. Journal of Natural Products. 70: 397-401. PMID 17328572 DOI: 10.1021/np0605790  1
2007 Gross H, Stockwell VO, Henkels MD, Nowak-Thompson B, Loper JE, Gerwick WH. The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Chemistry & Biology. 14: 53-63. PMID 17254952 DOI: 10.1016/j.chembiol.2006.11.007  1
2007 Andrianasolo EH, Goeger D, Gerwick WH. Mitsoamide: A cytotoxic linear lipopeptide from the Madagascar marine cyanobacterium Geitlerinema sp. Pure and Applied Chemistry. 79: 593-602. DOI: 10.1351/pac200779040593  1
2007 Kursar TA, Caballero-George CC, Capson TL, Cubilla-Rios L, Gerwick WH, Heller MV, Ibañez A, Linington RG, McPhail KL, Ortega-Barría E, Romero LI, Coley PD. Linking bioprospecting with sustainable development and conservation: The Panama case Biodiversity and Conservation. 16: 2789-2800. DOI: 10.1007/s10531-007-9214-2  1
2007 Grindberg RV, Shuman CF, Sorrels CM, Wingerd J, Gerwick WH. Neurotoxic Alkaloids from Cyanobacteria Modern Alkaloids: Structure, Isolation, Synthesis and Biology. 139-170. DOI: 10.1002/9783527621071.ch6  1
2007 Sánchez LA, Capitan Z, Romero LI, Ortega-Barría E, Gerwick WH, Cubilla-Rios L. Bio-assay guided isolation of germacranes with anti-protozoan activity from Magnolia sororum Natural Product Communications. 2: 1065-1069.  1
2006 Suyama TL, Gerwick WH. Practical total syntheses of epiquinamide enantiomers. Organic Letters. 8: 4541-3. PMID 16986945 DOI: 10.1021/ol061736p  1
2006 Andersson MX, Hamberg M, Kourtchenko O, Brunnström A, McPhail KL, Gerwick WH, Göbel C, Feussner I, Ellerström M. Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E. The Journal of Biological Chemistry. 281: 31528-37. PMID 16923817 DOI: 10.1074/jbc.M604820200  1
2006 Gu L, Jia J, Liu H, Håkansson K, Gerwick WH, Sherman DH. Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. Journal of the American Chemical Society. 128: 9014-5. PMID 16834357 DOI: 10.1021/ja0626382  1
2006 Flatt PM, O'Connell SJ, McPhail KL, Zeller G, Willis CL, Sherman DH, Gerwick WH. Characterization of the initial enzymatic steps of barbamide biosynthesis. Journal of Natural Products. 69: 938-44. PMID 16792414 DOI: 10.1021/np050523q  1
2006 Torres-Mendoza D, González J, Ortega-Barría E, Heller MV, Capson TL, McPhail K, Gerwick WH, Cubilla-Rios L. Weakly antimalarial flavonol arabinofuranosides from Calycolpus warszewiczianus. Journal of Natural Products. 69: 826-8. PMID 16724851 DOI: 10.1021/np050484i  1
2006 Gross H, Goeger DE, Hills P, Mooberry SL, Ballantine DL, Murray TF, Valeriote FA, Gerwick WH. Lophocladines, bioactive alkaloids from the red alga Lophocladia sp. Journal of Natural Products. 69: 640-4. PMID 16643042 DOI: 10.1021/np050519e  1
2006 Andrianasolo EH, France D, Cornell-Kennon S, Gerwick WH. DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii. Journal of Natural Products. 69: 576-9. PMID 16643029 DOI: 10.1021/np0503956  1
2006 Han B, Gross H, Goeger DE, Mooberry SL, Gerwick WH. Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 69: 572-5. PMID 16643028 DOI: 10.1021/np0503911  1
2006 Correa JE, Ríos CH, del Rosario Castillo A, Romero LI, Ortega-Barría E, Coley PD, Kursar TA, Heller MV, Gerwick WH, Rios LC. Minor alkaloids from Guatteria dumetorum with antileishmanial activity. Planta Medica. 72: 270-2. PMID 16534735 DOI: 10.1055/s-2005-916179  1
2006 Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 45: 1537-46. PMID 16460000 DOI: 10.1021/bi052333k  1
2006 Kursar TA, Caballero-George CC, Capson TL, Cubilla-Rios L, Gerwick WH, Gupta MP, Ibañez A, Linington RG, McPhail KL, Ortega-Barr?a E, Romero LI, Solis PN, Coley PD. Securing economic benefits and promoting conservation through bioprospecting Bioscience. 56: 1005-1012. DOI: 10.1641/0006-3568(2006)56[1005:SEBAPC]2.0.CO;2  1
2006 Simmons TL, McPhail KL, Ortega-Barría E, Mooberry SL, Gerwick WH. Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium Tetrahedron Letters. 47: 3387-3390. DOI: 10.1016/j.tetlet.2006.03.082  1
2005 LePage KT, Dickey RW, Gerwick WH, Jester EL, Murray TF. On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies. Critical Reviews in Neurobiology. 17: 27-50. PMID 16307526  1
2005 LePage KT, Goeger D, Yokokawa F, Asano T, Shioiri T, Gerwick WH, Murray TF. The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons. Toxicology Letters. 158: 133-9. PMID 16039402 DOI: 10.1016/j.toxlet.2005.03.007  1
2005 Sabry OM, Andrews S, McPhail KL, Goeger DE, Yokochi A, LePage KT, Murray TF, Gerwick WH. Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme. Journal of Natural Products. 68: 1022-30. PMID 16038542 DOI: 10.1021/np050051f  1
2005 Han B, Goeger D, Maier CS, Gerwick WH. The wewakpeptins, cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. The Journal of Organic Chemistry. 70: 3133-9. PMID 15822975 DOI: 10.1021/jo0478858  1
2005 Andrianasolo EH, Gross H, Goeger D, Musafija-Girt M, McPhail K, Leal RM, Mooberry SL, Gerwick WH. Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria. Organic Letters. 7: 1375-8. PMID 15787510 DOI: 10.1021/ol050188x  1
2005 Simmons TL, Andrianasolo E, McPhail K, Flatt P, Gerwick WH. Marine natural products as anticancer drugs. Molecular Cancer Therapeutics. 4: 333-42. PMID 15713904  1
2005 Han B, McPhail KL, Gross H, Goeger DE, Mooberry SL, Gerwick WH. Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula Tetrahedron. 61: 11723-11729. DOI: 10.1016/j.tet.2005.09.036  1
2005 Flatt PM, Gautschi JT, Thacker RW, Musafija-Girt M, Crews P, Gerwick WH. Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis Marine Biology. 147: 761-774. DOI: 10.1007/s00227-005-1614-9  1
2004 Edwards DJ, Gerwick WH. Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase. Journal of the American Chemical Society. 126: 11432-3. PMID 15366877 DOI: 10.1021/ja047876g  1
2004 Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH, Gerwick WH. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 67: 1356-67. PMID 15332855 DOI: 10.1021/np0499261  1
2004 Edwards DJ, Marquez BL, Nogle LM, McPhail K, Goeger DE, Roberts MA, Gerwick WH. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chemistry & Biology. 11: 817-33. PMID 15217615 DOI: 10.1016/j.chembiol.2004.03.030  1
2004 McPhail KL, France D, Cornell-Kennon S, Gerwick WH. Peyssonenynes a and B, novel enediyne oxylipins with DNA methyl transferase inhibitory activity from the red marine alga peyssonneliacaulifera. Journal of Natural Products. 67: 1010-3. PMID 15217284 DOI: 10.1021/np0400252  1
2004 Li WI, Marquez BL, Okino T, Yokokawa F, Shioiri T, Gerwick WH, Murray TF. Characterization of the preferred stereochemistry for the neuropharmacologic actions of antillatoxin. Journal of Natural Products. 67: 559-68. PMID 15104484 DOI: 10.1021/np0303409  1
2004 Gafner S, Bergeron C, McCollom MM, Cooper LM, McPhail KL, Gerwick WH, Angerhofer CK. Evaluation of the efficiency of three different solvent systems to extract triterpene saponins from roots of Panax quinquefolius using high-performance liquid chromatography. Journal of Agricultural and Food Chemistry. 52: 1546-50. PMID 15030209 DOI: 10.1021/jf0307503  1
2004 Takamatsu S, Nagle DG, Gerwick WH. Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1 mediated cell adhesion. Planta Medica. 70: 127-31. PMID 14994189 DOI: 10.1055/s-2004-815488  1
2004 Bobzin SC, Cardellina JH, Gerwick WH, Okuda RK, Harper MK, Ireland CM, Okuda RR. Special issue in honor of D. John Faulkner and Paul J. Scheuer Journal of Natural Products. 67: 1201-1203. DOI: 10.1021/np049784a  1
2004 Yokokawa F, Asano T, Okino T, Gerwick WH, Shioiri T. An expeditious total synthesis of kalkitoxins: Determination of the absolute stereostructure of natural kalkitoxin Tetrahedron. 60: 6859-6880. DOI: 10.1016/j.tet.2004.06.014  1
2004 Williamson RT, Singh IP, Gerwick WH. Taveuniamides: New chlorinated toxins from a mixed assemblage of marine cyanobacteria Tetrahedron. 60: 7025-7033. DOI: 10.1016/j.tet.2004.02.076  1
2003 Han B, McPhail KL, Ligresti A, Di Marzo V, Gerwick WH. Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. Journal of Natural Products. 66: 1364-8. PMID 14575438 DOI: 10.1021/np030242n  1
2003 Tan LT, Sitachitta N, Gerwick WH. The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 66: 764-71. PMID 12828459 DOI: 10.1021/np020492o  1
2003 Takamatsu S, Hodges TW, Rajbhandari I, Gerwick WH, Hamann MT, Nagle DG. Marine natural products as novel antioxidant prototypes. Journal of Natural Products. 66: 605-8. PMID 12762791 DOI: 10.1021/np0204038  1
2003 Nogle LM, Gerwick WH. Diverse secondary metabolites from a Puerto Rican collection of Lyngbyamajuscula. Journal of Natural Products. 66: 217-20. PMID 12608852 DOI: 10.1021/np020332c  1
2003 McPhail KL, Gerwick WH. Three new malyngamides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 66: 132-5. PMID 12542362 DOI: 10.1021/np0204186  1
2003 Nogle LM, Marquez BL, Gerwick WH. Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula. Organic Letters. 5: 3-6. PMID 12509876 DOI: 10.1021/ol026811k  1
2003 Crews P, Gerwick WH, Schmitz FJ, France D, Bair KW, Wright AE, Hallock Y. Molecular approaches to discover marine natural product anticancer leads - An update from a Drug Discovery Group Collaboration Pharmaceutical Biology. 41: 39-52. DOI: 10.1080/1388020039051743  1
2002 Williamson RT, Boulanger A, Vulpanovici A, Roberts MA, Gerwick WH. Structure and absolute stereochemistry of phormidolide, a new toxic metabolite from the marine cyanobacterium Phormidium sp. The Journal of Organic Chemistry. 67: 7927-36. PMID 12423120 DOI: 10.1021/jo020240s  1
2002 Stevenson CS, Capper EA, Roshak AK, Marquez B, Eichman C, Jackson JR, Mattern M, Gerwick WH, Jacobs RS, Marshall LA. The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. The Journal of Pharmacology and Experimental Therapeutics. 303: 858-66. PMID 12388673 DOI: 10.1124/jpet.102.036350  1
2002 Chang Z, Flatt P, Gerwick WH, Nguyen VA, Willis CL, Sherman DH. The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene. 296: 235-47. PMID 12383521  0.56
2002 Tan LT, Márquez BL, Gerwick WH. Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. Journal of Natural Products. 65: 925-8. PMID 12088441 DOI: 10.1021/np010526c  1
2002 Marquez BL, Watts KS, Yokochi A, Roberts MA, Verdier-Pinard P, Jimenez JI, Hamel E, Scheuer PJ, Gerwick WH. Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly Journal of Natural Products. 65: 866-871. PMID 12088429 DOI: 10.1021/np0106283  1
2002 Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, Gerwick WH. Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA. Archives of Biochemistry and Biophysics. 401: 11-20. PMID 12054482 DOI: 10.1016/S0003-9861(02)00002-4  1
2002 Stevenson CS, Capper EA, Roshak AK, Marquez B, Grace K, Gerwick WH, Jacobs RS, Marshall LA. Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 51: 112-4. PMID 11926312  1
2002 Nogle LM, Gerwick WH. Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Organic Letters. 4: 1095-8. PMID 11922791 DOI: 10.1021/ol017275j  1
2002 Nogle LM, Gerwick WH. Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula. Journal of Natural Products. 65: 21-4. PMID 11809058 DOI: 10.1021/np010348n  1
2001 Gerwick WH, Tan LT, Sitachitta N. Nitrogen-containing metabolites from marine cyanobacteria. The Alkaloids. Chemistry and Biology. 57: 75-184. PMID 11705123  1
2001 Nogle LM, Okino T, Gerwick WH. Antillatoxin B, a neurotoxic lipopeptide from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 64: 983-5. PMID 11473443 DOI: 10.1021/np010107f  1
2001 Nogle LM, Williamson RT, Gerwick WH. Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species. Journal of Natural Products. 64: 716-9. PMID 11421730 DOI: 10.1021/np000634j  1
2000 Milligan KE, Marquez BL, Williamson RT, Gerwick WH. Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 63: 1440-3. PMID 11076574 DOI: 10.1021/np000133y  1
2000 Milligan KE, Márquez B, Williamson RT, Davies-Coleman M, Gerwick WH. Two new malyngamides from a Madagascan Lyngbya majuscula. Journal of Natural Products. 63: 965-8. PMID 10924175 DOI: 10.1021/np000038p  1
2000 Tan LT, Okino T, Gerwick WH. Hermitamides A and B, toxic malyngamide-type natural products from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 63: 952-5. PMID 10924172 DOI: 10.1021/np000037x  1
2000 Williamson RT, Carney JR, Gerwick WH. Application of the BIRD sandwich for the rapid and accurate determination of (1)H-(1)H NMR coupling constants in higher order spin systems. Journal of Natural Products. 63: 876-8. PMID 10869227 DOI: 10.1021/np990564k  1
2000 Williamson RT, Chapin EL, Carr AW, Gilbert JR, Graupner PR, Lewer P, McKamey P, Carney JR, Gerwick WH. New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures. Organic Letters. 2: 289-92. PMID 10814304  1
2000 Tan LT, Williamson RT, Gerwick WH, Watts KS, McGough K, Jacobs R. cis,cis- and trans,trans-ceratospongamide, new bioactive cyclic heptapeptides from the Indonesian red alga Ceratodictyon spongiosum and symbiotic sponge Sigmadocia symbiotica. The Journal of Organic Chemistry. 65: 419-25. PMID 10813950 DOI: 10.1021/jo991165x  1
2000 Sitachitta N, Williamson RT, Gerwick WH. Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species. Journal of Natural Products. 63: 197-200. PMID 10691708 DOI: 10.1021/np990466z  1
1999 Singh IP, Milligan KE, Gerwick WH. Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 62: 1333-5. PMID 10514329 DOI: 10.1021/np990162c  1
1999 Verdier-Pinard P, Sitachitta N, Rossi JV, Sackett DL, Gerwick WH, Hamel E. Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin. Archives of Biochemistry and Biophysics. 370: 51-8. PMID 10496976 DOI: 10.1006/abbi.1999.1363  1
1998 Bisogno T, Melck D, De Petrocellis L, Bobrov MYu, Gretskaya NM, Bezuglov VV, Sitachitta N, Gerwick WH, Di Marzo V. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochemical and Biophysical Research Communications. 248: 515-22. PMID 9703957 DOI: 10.1006/bbrc.1998.8874  1
1998 Sitachitta N, Gerwick WH. Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 61: 681-4. PMID 9599279 DOI: 10.1021/np970576a  1
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