Jon C. Clardy, Ph.D. - Publications

Affiliations: 
1970-1977 Chemistry Iowa State University, Ames, IA, United States 
 1978-2008 Chemistry Cornell University, Ithaca, NY, United States 
 2009- Chemistry Harvard University, Cambridge, MA, United States 
Area:
natural products
Website:
http://www.broadinstitute.org/about/bios/bio-clardy.html

311 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J. , a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide. Proceedings of the National Academy of Sciences of the United States of America. PMID 31182571 DOI: 10.1073/pnas.1904099116  0.36
2019 Rollins-Smith LA, Ruzzini AC, Fites JS, Reinert LK, Hall EM, Joosse BA, Ravikumar VI, Huebner MI, Aka A, Kehs MH, Gillard BM, Doe E, Tasca JA, Umile TP, Clardy J, et al. Metabolites involved in immune evasion by include the polyamine spermidine. Infection and Immunity. PMID 30833338 DOI: 10.1128/IAI.00035-19  0.44
2018 Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J, McDonald D, Dietrich D, Ramadhar TR, Lekbua A, Mroue N, Liston C, Stewart EJ, Dubin MJ, Zengler K, ... ... Clardy J, et al. GABA-modulating bacteria of the human gut microbiota. Nature Microbiology. PMID 30531975 DOI: 10.1038/s41564-018-0307-3  0.56
2018 Li H, Sosa-Calvo J, Horn HA, Pupo MT, Clardy J, Rabeling C, Schultz TR, Currie CR. Convergent evolution of complex structures for ant-bacterial defensive symbiosis in fungus-farming ants. Proceedings of the National Academy of Sciences of the United States of America. PMID 30282739 DOI: 10.1073/pnas.1809332115  0.56
2018 Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R. Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen. Proceedings of the National Academy of Sciences of the United States of America. PMID 30228116 DOI: 10.1073/pnas.1807613115  0.48
2018 Coutinho BG, Mevers E, Schaefer AL, Pelletier DA, Harwood CS, Clardy J, Greenberg EP. A plant-responsive bacterial-signaling system senses an ethanolamine derivative. Proceedings of the National Academy of Sciences of the United States of America. PMID 30190434 DOI: 10.1073/pnas.1809611115  0.32
2018 Ganley J, Carr G, Ioerger T, Sacchettini J, Clardy J, Derbyshire E. Discovery of antimicrobial lipodepsipeptides produced by a Serratia sp. within mosquito microbiomes. Chembiochem : a European Journal of Chemical Biology. PMID 29700993 DOI: 10.1002/cbic.201800124  0.48
2018 Böttcher T, Szamosvári D, Clardy J. A repeating sulfated galactan motif resuscitates dormant . Applied and Environmental Microbiology. PMID 29678921 DOI: 10.1128/AEM.00745-18  0.76
2018 Puri AW, Mevers E, Ramadhar TR, Petras D, Liu D, Piel J, Dorrestein PC, Greenberg P, Lidstrom ME, Clardy J. Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism. Journal of the American Chemical Society. PMID 29361220 DOI: 10.1021/jacs.7b12240  0.56
2018 Paludo CR, Menezes C, Silva-Junior EA, Vollet-Neto A, Andrade-Dominguez A, Pishchany G, Khadempour L, do Nascimento FS, Currie CR, Kolter R, Clardy J, Pupo MT. Stingless Bee Larvae Require Fungal Steroid to Pupate. Scientific Reports. 8: 1122. PMID 29348592 DOI: 10.1038/s41598-018-19583-9  0.56
2017 Ramadhar TR, Zheng SL, Chen YS, Clardy J. The Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds. Crystengcomm. 19: 4528-4534. PMID 29225511 DOI: 10.1039/C7CE00885F  0.56
2017 Guo H, Rischer M, Sperfeld M, Weigel C, Menzel KD, Clardy J, Beemelmanns C. Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorganic & Medicinal Chemistry. PMID 28893599 DOI: 10.1016/j.bmc.2017.06.053  0.76
2017 Woznica A, Gerdt JP, Hulett RE, Clardy J, King N. Mating in the Closest Living Relatives of Animals Is Induced by a Bacterial Chondroitinase. Cell. PMID 28867285 DOI: 10.1016/j.cell.2017.08.005  0.76
2017 Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy J. Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Organic Letters. PMID 28326787 DOI: 10.1021/acs.orglett.7b00545  0.76
2017 Beemelmanns C, Ramadhar TR, Kim KH, Klassen JL, Cao S, Wyche TP, Hou Y, Poulsen M, Bugni TS, Currie CR, Clardy J. Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Organic Letters. PMID 28207275 DOI: 10.1021/acs.orglett.6b03831  0.76
2016 Garcia DM, Dietrich D, Clardy J, Jarosz DF. A common bacterial metabolite elicits prion-based bypass of glucose repression. Elife. 5. PMID 27906649 DOI: 10.7554/eLife.17978  0.32
2016 Segev E, Wyche TP, Kim KH, Petersen J, Ellebrandt C, Vlamakis H, Barteneva N, Paulson JN, Chai L, Clardy J, Kolter R. Dynamic metabolic exchange governs a marine algal-bacterial interaction. Elife. 5. PMID 27855786 DOI: 10.7554/eLife.17473  0.48
2016 Van Arnam EB, Ruzzini AC, Sit CS, Horn H, Pinto-Tomás AA, Currie CR, Clardy J. Selvamicin, an atypical antifungal polyene from two alternative genomic contexts. Proceedings of the National Academy of Sciences of the United States of America. PMID 27803316 DOI: 10.1073/pnas.1613285113  0.56
2016 Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Clardy JC, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/nature19804  0.68
2016 Lee SR, Beemelmanns C, Tsuma LM, Clardy J, Cao S, Kim KH. A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT. Natural Product Communications. 11: 461-3. PMID 27396193  0.76
2016 Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 166: 126-139. PMID 27368101 DOI: 10.1016/j.cell.2016.05.042  0.52
2016 Woznica A, Cantley AM, Beemelmanns C, Freinkman E, Clardy J, King N. Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proceedings of the National Academy of Sciences of the United States of America. PMID 27354530 DOI: 10.1073/pnas.1605015113  0.76
2016 Paludo CR, Ruzzini AC, Silva-Junior EA, Pishchany G, Currie CR, Nascimento FS, Kolter RG, Clardy J, Pupo MT. Whole-Genome Sequence of Bacillus sp. SDLI1, Isolated from the Social Bee Scaptotrigona depilis. Genome Announcements. 4. PMID 27013050 DOI: 10.1128/genomeA.00174-16  0.56
2016 Cantley AM, Woznica A, Beemelmanns C, King N, Clardy J. Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates. Journal of the American Chemical Society. PMID 26998963 DOI: 10.1021/jacs.6b01190  0.84
2016 Rischer M, Klassen JL, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C. Draft Genome Sequence of Shewanella sp. Strain P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia echinata. Genome Announcements. 4. PMID 26893410 DOI: 10.1128/genomeA.00003-16  0.76
2016 Böttcher T, Elliott HL, Clardy J. Dynamics of snake-like swarming behavior of vibrio alginolyticus Biophysical Journal. 110: 981-992. DOI: 10.1016/j.bpj.2015.12.037  0.84
2015 Klassen JL, Wolf T, Rischer M, Guo H, Shelest E, Clardy J, Beemelmanns C. Draft Genome Sequences of Six Pseudoalteromonas Strains, P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25, and P1-26, Which Induce Larval Settlement and Metamorphosis in Hydractinia echinata. Genome Announcements. 3. PMID 26679587 DOI: 10.1128/genomeA.01477-15  0.76
2015 Klassen JL, Rischer M, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C. Genome Sequences of Three Pseudoalteromonas Strains (P1-8, P1-11, and P1-30), Isolated from the Marine Hydroid Hydractinia echinata. Genome Announcements. 3. PMID 26659670 DOI: 10.1128/genomeA.01380-15  0.76
2015 Sit CS, Ruzzini AC, Van Arnam EB, Ramadhar TR, Currie CR, Clardy J. Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants. Proceedings of the National Academy of Sciences of the United States of America. 112: 13150-4. PMID 26438860 DOI: 10.1073/pnas.1515348112  0.84
2015 Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, ... Clardy J, et al. Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. Chemistry & Biology. PMID 26320861 DOI: 10.1016/j.chembiol.2015.07.016  0.56
2015 Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW. Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. The Journal of Biological Chemistry. PMID 26242912 DOI: 10.1074/jbc.M115.662445  0.84
2015 Kim KH, Clardy J, Senger D, Cao S. Chakyunglupulins A and B, two novel 4,8,8-trimethylcyclooct-2-enone derivatives from Barleria lupulina. Tetrahedron Letters. 56: 2732-2734. PMID 26240452 DOI: 10.1016/j.tetlet.2015.04.023  0.84
2015 Kim KH, Park YJ, Chung KH, Yip ML, Clardy J, Senger D, Cao S. Iridoid glycosides from Barleria lupulina. Journal of Natural Products. 78: 320-4. PMID 25611215 DOI: 10.1021/np500791a  0.84
2015 Ramadhar TR, Zheng SL, Chen YS, Clardy J. Analysis of rapidly synthesized guest-filled porous complexes with synchrotron radiation: practical guidelines for the crystalline sponge method. Acta Crystallographica. Section a, Foundations and Advances. 71: 46-58. PMID 25537388 DOI: 10.1107/S2053273314019573  0.56
2014 Kim KH, Ramadhar TR, Beemelmanns C, Cao S, Poulsen M, Currie CR, Clardy J. Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp. Chemical Science (Royal Society of Chemistry : 2010). 5: 4333-4338. PMID 25386334 DOI: 10.1039/C4SC01136H  0.84
2014 Seyedsayamdost MR, Wang R, Kolter R, Clardy J. Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules. Journal of the American Chemical Society. 136: 15150-3. PMID 25295497 DOI: 10.1021/ja508782y  0.84
2014 Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach MA. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell. 158: 1402-14. PMID 25215495 DOI: 10.1016/j.cell.2014.08.032  0.84
2014 Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J. Chemical interrogation of the malaria kinome. Chembiochem : a European Journal of Chemical Biology. 15: 1920-30. PMID 25111632 DOI: 10.1002/cbic.201400025  0.84
2014 Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Molecular Pharmacology. 86: 406-16. PMID 25086086 DOI: 10.1124/mol.114.092403  0.84
2014 Cimermancic P, Medema MH, Claesen J, Kurita K, Wieland Brown LC, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J, Birren BW, Takano E, Sali A, Linington RG, Fischbach MA. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell. 158: 412-21. PMID 25036635 DOI: 10.1016/j.cell.2014.06.034  0.84
2014 Beemelmanns C, Woznica A, Alegado RA, Cantley AM, King N, Clardy J. Synthesis of the rosette-inducing factor RIF-1 and analogs. Journal of the American Chemical Society. 136: 10210-3. PMID 24983513 DOI: 10.1021/ja5046692  0.84
2014 Book AJ, Lewin GR, McDonald BR, Takasuka TE, Doering DT, Adams AS, Blodgett JA, Clardy J, Raffa KF, Fox BG, Currie CR. Cellulolytic Streptomyces strains associated with herbivorous insects share a phylogenetically linked capacity to degrade lignocellulose. Applied and Environmental Microbiology. 80: 4692-701. PMID 24837391 DOI: 10.1128/AEM.01133-14  0.84
2014 Seyedsayamdost MR, Clardy J. Natural products and synthetic biology. Acs Synthetic Biology. 3: 745-7. PMID 24742095 DOI: 10.1021/sb400025p  0.84
2014 Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, ... Clardy J, et al. Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chemistry & Biology. 21: 509-18. PMID 24684906 DOI: 10.1016/j.chembiol.2014.01.014  0.84
2014 Stallforth P, Clardy J. Atlas for drug discovery. Proceedings of the National Academy of Sciences of the United States of America. 111: 3655-6. PMID 24554079 DOI: 10.1073/pnas.1400516111  0.84
2014 Ramadhar TR, Beemelmanns C, Currie CR, Clardy J. Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. The Journal of Antibiotics. 67: 53-8. PMID 23921819 DOI: 10.1038/ja.2013.77  0.84
2013 Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J. A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proceedings of the National Academy of Sciences of the United States of America. 110: 14528-33. PMID 23898207 DOI: 10.1073/pnas.1308199110  0.84
2013 Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA. Production of α-galactosylceramide by a prominent member of the human gut microbiota. Plos Biology. 11: e1001610. PMID 23874157 DOI: 10.1371/journal.pbio.1001610  0.84
2013 Stallforth P, Clardy J. X-ray crystallography: One size fits most. Nature. 495: 456-7. PMID 23538827 DOI: 10.1038/495456a  0.84
2013 Cryan LM, Bazinet L, Habeshian KA, Cao S, Clardy J, Christensen KA, Rogers MS. 1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2. Journal of Medicinal Chemistry. 56: 1940-5. PMID 23394144 DOI: 10.1021/jm301558t  0.84
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/c2np20085f  0.44
2012 Chandler JR, Truong TT, Silva PM, Seyedsayamdost MR, Carr G, Radey M, Jacobs MA, Sims EH, Clardy J, Greenberg EP. Bactobolin resistance is conferred by mutations in the L2 ribosomal protein. Mbio. 3. PMID 23249812 DOI: 10.1128/mBio.00499-12  0.84
2012 Harris ES, Cao S, Schoville SD, Dong C, Wang W, Jian Z, Zhao Z, Eisenberg DM, Clardy J. Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach. Plos One. 7: e50753. PMID 23209822 DOI: 10.1371/journal.pone.0050753  0.84
2012 Seyedsayamdost MR, Traxler MF, Clardy J, Kolter R. Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Methods in Enzymology. 517: 89-109. PMID 23084935 DOI: 10.1016/B978-0-12-404634-4.00005-X  0.84
2012 Adler C, Corbalán NS, Seyedsayamdost MR, Pomares MF, de Cristóbal RE, Clardy J, Kolter R, Vincent PA. Catecholate siderophores protect bacteria from pyochelin toxicity. Plos One. 7: e46754. PMID 23071628 DOI: 10.1371/journal.pone.0046754  0.84
2012 Alegado RA, Brown LW, Cao S, Dermenjian RK, Zuzow R, Fairclough SR, Clardy J, King N. A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals. Elife. 1: e00013. PMID 23066504 DOI: 10.7554/eLife.00013  0.84
2012 Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of Natural Products. 75: 1806-9. PMID 23025282 DOI: 10.1021/np300380t  0.84
2012 Stallforth P, Clardy J. Protein evolution: when two become three. Current Biology : Cb. 22: R685-7. PMID 22974996 DOI: 10.1016/j.cub.2012.07.055  0.84
2012 Traxler MF, Seyedsayamdost MR, Clardy J, Kolter R. Interspecies modulation of bacterial development through iron competition and siderophore piracy. Molecular Microbiology. 86: 628-44. PMID 22931126 DOI: 10.1111/mmi.12008  0.84
2012 Cao S, Cryan L, Habeshian KA, Murillo C, Tamayo-Castillo G, Rogers MS, Clardy J. Phenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi. Bioorganic & Medicinal Chemistry Letters. 22: 5885-8. PMID 22910038 DOI: 10.1016/j.bmcl.2012.07.075  0.84
2012 Seyedsayamdost MR, Cleto S, Carr G, Vlamakis H, João Vieira M, Kolter R, Clardy J. Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. Journal of the American Chemical Society. 134: 13550-3. PMID 22830960 DOI: 10.1021/ja304941d  0.84
2012 Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy J. Small molecule perimeter defense in entomopathogenic bacteria. Proceedings of the National Academy of Sciences of the United States of America. 109: 10821-6. PMID 22711807 DOI: 10.1073/pnas.1201160109  0.84
2012 Crawford JM, Clardy J. Microbial genome mining answers longstanding biosynthetic questions. Proceedings of the National Academy of Sciences of the United States of America. 109: 7589-90. PMID 22550177 DOI: 10.1073/pnas.1205361109  0.84
2012 Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick R. A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell. 149: 684-92. PMID 22541437 DOI: 10.1016/j.cell.2012.02.055  0.84
2012 Cao S, McMillin DW, Tamayo G, Delmore J, Mitsiades CS, Clardy J. Inhibition of tumor cells interacting with stromal cells by xanthones isolated from a Costa Rican Penicillium sp. Journal of Natural Products. 75: 793-7. PMID 22458669 DOI: 10.1021/np2009863  0.84
2012 Derbyshire ER, Mazitschek R, Clardy J. Characterization of Plasmodium liver stage inhibition by halofuginone. Chemmedchem. 7: 844-9. PMID 22438279 DOI: 10.1002/cmdc.201200045  0.84
2012 Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI. A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. Plos One. 7: e31307. PMID 22359585 DOI: 10.1371/journal.pone.0031307  0.84
2012 Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. Acs Chemical Biology. 7: 340-9. PMID 22050377 DOI: 10.1021/cb200353m  0.84
2011 Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, ... ... Clardy J, et al. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chemistry & Biology. 18: 1602-10. PMID 22195562 DOI: 10.1016/j.chembiol.2011.09.016  0.84
2011 Crawford JM, Mahlstedt SA, Malcolmson SJ, Clardy J, Walsh CT. Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. Chemistry & Biology. 18: 1102-12. PMID 21944749 DOI: 10.1016/j.chembiol.2011.07.009  0.84
2011 Seyedsayamdost MR, Carr G, Kolter R, Clardy J. Roseobacticides: small molecule modulators of an algal-bacterial symbiosis. Journal of the American Chemical Society. 133: 18343-9. PMID 21928816 DOI: 10.1021/ja207172s  0.84
2011 Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy J. NRPS substrate promiscuity diversifies the xenematides. Organic Letters. 13: 5144-7. PMID 21888371 DOI: 10.1021/ol2020237  0.84
2011 Harris ES, Cao S, Littlefield BA, Craycroft JA, Scholten R, Kaptchuk T, Fu Y, Wang W, Liu Y, Chen H, Zhao Z, Clardy J, Woolf AD, Eisenberg DM. Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines. The Science of the Total Environment. 409: 4297-305. PMID 21824641 DOI: 10.1016/j.scitotenv.2011.07.032  0.84
2011 Seyedsayamdost MR, Traxler MF, Zheng SL, Kolter R, Clardy J. Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. Journal of the American Chemical Society. 133: 11434-7. PMID 21699219 DOI: 10.1021/ja203577e  0.84
2011 Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy J. Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264. Organic Letters. 13: 3048-51. PMID 21615115 DOI: 10.1021/ol200922s  0.84
2011 Crawford JM, Clardy J. Bacterial symbionts and natural products. Chemical Communications (Cambridge, England). 47: 7559-66. PMID 21594283 DOI: 10.1039/c1cc11574j  0.84
2011 Seyedsayamdost MR, Case RJ, Kolter R, Clardy J. The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nature Chemistry. 3: 331-5. PMID 21430694 DOI: 10.1038/nchem.1002  0.84
2011 Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, ... ... Clardy J, et al. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 55: 2612-22. PMID 21422215 DOI: 10.1128/AAC.01714-10  0.84
2011 Harris ES, Erickson SD, Tolopko AN, Cao S, Craycroft JA, Scholten R, Fu Y, Wang W, Liu Y, Zhao Z, Clardy J, Shamu CE, Eisenberg DM. Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs. Journal of Ethnopharmacology. 135: 590-3. PMID 21420479 DOI: 10.1016/j.jep.2011.03.029  0.52
2011 Marks KM, Park ES, Arefolov A, Russo K, Ishihara K, Ring JE, Clardy J, Clarke AS, Pelish HE. The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes. Journal of Natural Products. 74: 567-73. PMID 21348461 DOI: 10.1021/np100429s  0.84
2011 Oh DC, Poulsen M, Currie CR, Clardy J. Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp. Organic Letters. 13: 752-5. PMID 21247188 DOI: 10.1021/ol102991d  0.84
2011 Eisenberg DM, Harris ES, Littlefield BA, Cao S, Craycroft JA, Scholten R, Bayliss P, Fu Y, Wang W, Qiao Y, Zhao Z, Chen H, Liu Y, Kaptchuk T, Hahn WC, ... ... Clardy J, et al. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia. 82: 17-33. PMID 21108995 DOI: 10.1016/j.fitote.2010.11.017  0.84
2010 Mao Y, Xu X, Xu W, Ishida Y, Leal WS, Ames JB, Clardy J. Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone. Proceedings of the National Academy of Sciences of the United States of America. 107: 19102-7. PMID 20956299 DOI: 10.1073/pnas.1012274107  0.48
2010 Cao S, Blodgett JA, Clardy J. Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain. Organic Letters. 12: 4652-4. PMID 20843016 DOI: 10.1021/ol1020064  0.52
2010 Cao S, Ross L, Tamayo G, Clardy J. Asterogynins: secondary metabolites from a Costa Rican endophytic fungus. Organic Letters. 12: 4661-3. PMID 20839869 DOI: 10.1021/ol101972g  0.84
2010 Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R. A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity. Organic Letters. 12: 3998-4001. PMID 20718474 DOI: 10.1021/ol101566h  0.84
2010 Schloss PD, Allen HK, Klimowicz AK, Mlot C, Gross JA, Savengsuksa S, McEllin J, Clardy J, Ruess RW, Handelsman J. Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin. Dna and Cell Biology. 29: 533-41. PMID 20626288 DOI: 10.1089/dna.2010.1020  0.84
2010 Blodgett JA, Oh DC, Cao S, Currie CR, Kolter R, Clardy J. Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. Proceedings of the National Academy of Sciences of the United States of America. 107: 11692-7. PMID 20547882 DOI: 10.1073/pnas.1001513107  0.84
2010 Kontnik R, Crawford JM, Clardy J. Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. Acs Chemical Biology. 5: 659-65. PMID 20524642 DOI: 10.1021/cb100117k  0.84
2010 D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, Lewis K. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chemistry & Biology. 17: 254-64. PMID 20338517 DOI: 10.1016/j.chembiol.2010.02.010  0.84
2010 Ndiaye D, Patel V, Demas A, LeRoux M, Ndir O, Mboup S, Clardy J, Lakshmanan V, Daily JP, Wirth DF. A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. The American Journal of Tropical Medicine and Hygiene. 82: 228-30. PMID 20133997 DOI: 10.4269/ajtmh.2010.09-0470  0.84
2010 Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J. Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Organic Letters. 12: 716-9. PMID 20095633 DOI: 10.1021/ol902751x  0.84
2010 Dawlaty J, Zhang X, Fischbach MA, Clardy J. Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases. Journal of Natural Products. 73: 441-6. PMID 20041689 DOI: 10.1021/np900685z  0.84
2010 Crawford JM, Kontnik R, Clardy J. Regulating alternative lifestyles in entomopathogenic bacteria. Current Biology : Cb. 20: 69-74. PMID 20022247 DOI: 10.1016/j.cub.2009.10.059  0.84
2009 Freinkman E, Oh DC, Scott JJ, Currie CR, Clardy J. Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum. Tetrahedron Letters. 50: 6834-6837. PMID 20160864 DOI: 10.1016/j.tetlet.2009.09.120  0.84
2009 Hollenhorst MA, Clardy J, Walsh CT. The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. Biochemistry. 48: 10467-72. PMID 19807062 DOI: 10.1021/bi9013165  0.84
2009 Kim K, Sato K, Shibuya M, Zeiger DM, Butcher RA, Ragains JR, Clardy J, Touhara K, Sengupta P. Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Science (New York, N.Y.). 326: 994-8. PMID 19797623 DOI: 10.1126/science.1176331  0.84
2009 Martyn DC, Beletsky G, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Liang B, Clardy J. Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters. 19: 5657-60. PMID 19699641 DOI: 10.1016/j.bmcl.2009.08.024  0.84
2009 Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8236-47. PMID 19553463 DOI: 10.1523/JNEUROSCI.1805-09.2009  0.84
2009 Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorganic & Medicinal Chemistry Letters. 19: 4223-7. PMID 19523825 DOI: 10.1016/j.bmcl.2009.05.105  0.84
2009 Clardy J, Fischbach MA, Currie CR. The natural history of antibiotics. Current Biology : Cb. 19: R437-41. PMID 19515346 DOI: 10.1016/j.cub.2009.04.001  0.84
2009 Macosko EZ, Pokala N, Feinberg EH, Chalasani SH, Butcher RA, Clardy J, Bargmann CI. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. Nature. 458: 1171-5. PMID 19349961 DOI: 10.1038/nature07886  0.84
2009 Oh DC, Poulsen M, Currie CR, Clardy J. Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. Nature Chemical Biology. 5: 391-3. PMID 19330011 DOI: 10.1038/nchembio.159  0.84
2009 Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. Journal of Medicinal Chemistry. 52: 2185-7. PMID 19317450 DOI: 10.1021/jm801654y  0.84
2009 Rush MA, Baniecki ML, Mazitschek R, Cortese JF, Wiegand R, Clardy J, Wirth DF. Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrobial Agents and Chemotherapy. 53: 2564-8. PMID 19307367 DOI: 10.1128/AAC.01466-08  0.84
2009 Wieland Brown LC, Acker MG, Clardy J, Walsh CT, Fischbach MA. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proceedings of the National Academy of Sciences of the United States of America. 106: 2549-53. PMID 19196969 DOI: 10.1073/pnas.0900008106  0.84
2009 Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proceedings of the National Academy of Sciences of the United States of America. 106: 1875-9. PMID 19174521 DOI: 10.1073/pnas.0810338106  0.84
2009 Oh DC, Scott JJ, Currie CR, Clardy J. Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp. Organic Letters. 11: 633-6. PMID 19125624 DOI: 10.1021/ol802709x  0.84
2009 Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 972-5. PMID 19097788 DOI: 10.1016/j.bmcl.2008.11.071  0.84
2008 Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J. Actin-aggregating cucurbitacins from Physocarpus capitatus. Journal of Natural Products. 71: 1927-9. PMID 18959442 DOI: 10.1021/np8005259  0.84
2008 Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. The Journal of Biological Chemistry. 283: 35078-85. PMID 18842591 DOI: 10.1074/jbc.M804990200  0.84
2008 Scott JJ, Oh DC, Yuceer MC, Klepzig KD, Clardy J, Currie CR. Bacterial protection of beetle-fungus mutualism. Science (New York, N.Y.). 322: 63. PMID 18832638 DOI: 10.1126/science.1160423  0.84
2008 Butcher RA, Ragains JR, Kim E, Clardy J. A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components. Proceedings of the National Academy of Sciences of the United States of America. 105: 14288-92. PMID 18791072 DOI: 10.1073/pnas.0806676105  0.48
2008 Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. Plos One. 3: e2082. PMID 18461159 DOI: 10.1371/journal.pone.0002082  0.84
2008 Mazitschek R, Patel V, Wirth DF, Clardy J. Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorganic & Medicinal Chemistry Letters. 18: 2809-12. PMID 18430569 DOI: 10.1016/j.bmcl.2008.04.007  0.84
2008 Georgiades SN, Clardy J. Synthetic libraries of tyrosine-derived bacterial metabolites. Bioorganic & Medicinal Chemistry Letters. 18: 3117-21. PMID 17983747 DOI: 10.1016/j.bmcl.2007.10.058  0.76
2007 Lautenschlager C, Leal WS, Clardy J. Bombyx mori Pheromone-Binding Protein Binding Nonpheromone Ligands: Implications for Pheromone Recognition Structure. 15: 1148-1154. PMID 17850754 DOI: 10.1016/j.str.2007.07.013  0.84
2007 Schmitz K, Haggarty SJ, McPherson OM, Clardy J, Koehler AN. Detecting binding interactions using microarrays of natural product extracts. Journal of the American Chemical Society. 129: 11346-7. PMID 17718493 DOI: 10.1021/ja073965s  0.52
2007 Clardy J, Brady SF. Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. Journal of Bacteriology. 189: 6487-9. PMID 17586635 DOI: 10.1128/JB.00457-07  0.84
2007 Fischbach MA, Clardy J. One pathway, many products. Nature Chemical Biology. 3: 353-5. PMID 17576415 DOI: 10.1038/nchembio0707-353  0.84
2007 Butcher RA, Fujita M, Schroeder FC, Clardy J. Small-molecule pheromones that control dauer development in Caenorhabditis elegans. Nature Chemical Biology. 3: 420-2. PMID 17558398 DOI: 10.1038/nchembio.2007.3  0.48
2007 Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 104: 1506-9. PMID 17234808 DOI: 10.1073/pnas.0610503104  0.84
2007 Martyn DC, Jones DC, Fairlamb AH, Clardy J. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorganic & Medicinal Chemistry Letters. 17: 1280-3. PMID 17197182 DOI: 10.1016/j.bmcl.2006.12.016  0.84
2007 Schroeder FC, Gibson DM, Churchill AC, Sojikul P, Wursthorn EJ, Krasnoff SB, Clardy J. Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library. Angewandte Chemie (International Ed. in English). 46: 901-4. PMID 17183517 DOI: 10.1002/anie.200603821  0.56
2007 Baniecki ML, Wirth DF, Clardy J. High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrobial Agents and Chemotherapy. 51: 716-23. PMID 17116676 DOI: 10.1128/AAC.01144-06  0.84
2006 Clardy J, Fischbach MA, Walsh CT. New antibiotics from bacterial natural products. Nature Biotechnology. 24: 1541-50. PMID 17160060 DOI: 10.1038/nbt1266  0.84
2006 Amagata T, Morinaka BI, Amagata A, Tenney K, Valeriote FA, Lobkovsky E, Clardy J, Crews P. A chemical study of cyclic depsipeptides produced by a sponge-derived fungus Journal of Natural Products. 69: 1560-1565. PMID 17125221 DOI: 10.1021/np060178k  0.84
2006 Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 10: 321-30. PMID 17010675 DOI: 10.1016/j.ccr.2006.09.005  0.84
2006 Van Wagoner RM, Clardy J. FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding. Structure (London, England : 1993). 14: 1425-35. PMID 16962973 DOI: 10.1016/j.str.2006.07.005  0.84
2006 Georgiades SN, Clardy J. Preparation of a psammaplysene-based library. Organic Letters. 8: 4251-4. PMID 16956199 DOI: 10.1021/ol061599w  0.76
2006 Maloney KN, Hao W, Xu J, Gibbons J, Hucul J, Roll D, Brady SF, Schroeder FC, Clardy J. Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus. Organic Letters. 8: 4067-70. PMID 16928075 DOI: 10.1021/ol061556f  0.84
2006 Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. The Journal of Biological Chemistry. 281: 29897-904. PMID 16899456 DOI: 10.1074/jbc.M605394200  0.84
2006 Thammana S, Suzuki H, Lobkovsky E, Clardy J, Shimizu Y. Isolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp. Journal of Natural Products. 69: 365-8. PMID 16562836 DOI: 10.1021/np050401y  0.48
2006 Nonato MC, Widom J, Clardy J. Human methionine aminopeptidase type 2 in complex with l- and d-methionine Bioorganic and Medicinal Chemistry Letters. 16: 2580-2583. PMID 16540317 DOI: 10.1016/j.bmcl.2006.02.047  0.84
2006 Hurt DE, Widom J, Clardy J. Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. Acta Crystallographica. Section D, Biological Crystallography. 62: 312-23. PMID 16510978 DOI: 10.1107/S0907444905042642  0.32
2006 Hurt DE, Sutton AE, Clardy J. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 16: 1610-5. PMID 16406782 DOI: 10.1016/j.bmcl.2005.12.029  0.32
2006 Wright SAI, Clardy J, Jin M, Beer SV. The biosynthetic genes of pantocin A and pantocin B of Pantoea agglomerans Eh318 Acta Horticulturae. 704: 313-319.  0.84
2005 Brady SF, Clardy J. Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angewandte Chemie (International Ed. in English). 44: 7045-8. PMID 16217820 DOI: 10.1002/anie.200501942  0.84
2005 Brady SF, Clardy J. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angewandte Chemie (International Ed. in English). 44: 7063-5. PMID 16206308 DOI: 10.1002/anie.200501941  0.84
2005 Georgiades SN, Clardy J. Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export. Organic Letters. 7: 4091-4. PMID 16146359 DOI: 10.1021/ol0513286  0.76
2005 Lautenschlager C, Leal WS, Clardy J. Coil-to-helix transition and ligand release of Bombyx mori pheromone-binding protein Biochemical and Biophysical Research Communications. 335: 1044-1050. PMID 16111659 DOI: 10.1016/j.bbrc.2005.07.176  0.84
2005 Brady SF, Clardy J. N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli. Organic Letters. 7: 3613-6. PMID 16092832 DOI: 10.1021/ol0509585  0.84
2005 Weibel DB, Lee A, Mayer M, Brady SF, Bruzewicz D, Yang J, Diluzio WR, Clardy J, Whitesides GM. Bacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 6436-42. PMID 15982051 DOI: 10.1021/la047173c  0.84
2005 Schroeder FC, Kau TR, Silver PA, Clardy J. The psammaplysenes, specific inhibitors of FOXO1a nuclear export. Journal of Natural Products. 68: 574-6. PMID 15844952 DOI: 10.1021/np049624z  0.84
2004 Brady SF, Chao CJ, Clardy J. Long-chain N-acyltyrosine synthases from environmental DNA. Applied and Environmental Microbiology. 70: 6865-70. PMID 15528554 DOI: 10.1128/AEM.70.11.6865-6870.2004  0.84
2004 Brady SF, Clardy J. Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. Journal of Natural Products. 67: 1283-6. PMID 15332842 DOI: 10.1021/np0499766  0.84
2004 Chen H, Fujita M, Feng Q, Clardy J, Fink GR. Tyrosol is a quorum-sensing molecule in Candida albicans. Proceedings of the National Academy of Sciences of the United States of America. 101: 5048-52. PMID 15051880 DOI: 10.1073/pnas.0401416101  0.84
2004 Sonnenschein RN, Farias JJ, Tenney K, Mooberry SL, Lobkovsky E, Clardy J, Crews P. A further study of the cytotoxic constituents of a milnamide-producing sponge Organic Letters. 6: 779-782. PMID 14986973 DOI: 10.1021/ol036446c  0.84
2003 Amagata T, Amagata A, Tenney K, Valeriote FA, Lobkovsky E, Clardy J, Crews P. Unusual C25 Steroids Produced by a Sponge-Derived Penicillium citrinum Organic Letters. 5: 4393-4396. PMID 14602008 DOI: 10.1021/ol0356800  0.84
2003 Calero G, Gupta P, Nonato MC, Tandel S, Biehl ER, Hofmann SL, Clardy J. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2 Journal of Biological Chemistry. 278: 37957-37964. PMID 12855696 DOI: 10.1074/jbc.M301225200  0.84
2003 Jin M, Wright SA, Beer SV, Clardy J. The biosynthetic gene cluster of Pantocin a provides insights into biosynthesis and a tool for screening. Angewandte Chemie (International Ed. in English). 42: 2902-5. PMID 12833354 DOI: 10.1002/anie.200351054  0.4
2003 Jin M, Liu L, Wright SA, Beer SV, Clardy J. Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes. Angewandte Chemie (International Ed. in English). 42: 2898-901. PMID 12833353 DOI: 10.1002/anie.200351053  0.84
2003 Dahl JE, Moldowan JM, Peakman TM, Clardy JC, Lobkovsky E, Olmstead MM, May PW, Davis TJ, Steeds JW, Peters KE, Pepper A, Ekuan A, Carlson RM. Isolation and structural proof of the large diamond molecule, cyclohexamantane (C26H30). Angewandte Chemie (International Ed. in English). 42: 2040-4. PMID 12746817 DOI: 10.1002/anie.200250794  0.84
2003 Garo E, Starks CM, Jensen PR, Fenical W, Lobkovsky E, Clardy J. Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens. Journal of Natural Products. 66: 423-6. PMID 12662106 DOI: 10.1021/np0204390  0.48
2003 Amagata T, Whitman S, Johnson TA, Stessman CC, Loo CP, Lobkovsky E, Clardy J, Crews P, Holman TR. Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases Journal of Natural Products. 66: 230-235. PMID 12608855 DOI: 10.1021/np020462l  0.84
2003 Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proceedings of the National Academy of Sciences of the United States of America. 100: 868-73. PMID 12538866 DOI: 10.1073/pnas.0231020100  0.84
2003 Ireland CM, Aalbersberg W, Andersen RJ, Ayral-Kaloustian S, Berlinck RGS, Bernan V, Carter G, Churchill ACL, Clardy J, Concepcion GP, De Silva ED, Discafani C, Fojo T, Frost P, Gibson D, et al. Anticancer agents from unique natural products sources Pharmaceutical Biology. 41: 15-38. DOI: 10.1080/1388020039051742  0.84
2002 Thale Z, Johnson T, Tenney K, Wenzel PJ, Lobkovsky E, Clardy J, Media J, Pietraszkiewicz H, Valeriote FA, Crews P. Structures and cytotoxic properties of sponge-derived bisannulated acridines. The Journal of Organic Chemistry. 67: 9384-91. PMID 12492342 DOI: 10.1021/jo026459o  0.84
2002 Calero G, Wilson KF, Ly T, Rios-Steiner JL, Clardy JC, Cerione RA. Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nature Structural Biology. 9: 912-7. PMID 12434151 DOI: 10.1038/nsb874  0.84
2002 Gillespie DE, Brady SF, Bettermann AD, Cianciotto NP, Liles MR, Rondon MR, Clardy J, Goodman RM, Handelsman J. Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Applied and Environmental Microbiology. 68: 4301-6. PMID 12200279 DOI: 10.1128/AEM.68.9.4301-4306.2002  0.84
2002 Brady SF, Chao CJ, Clardy J. New natural product families from an environmental DNA (eDNA) gene cluster. Journal of the American Chemical Society. 124: 9968-9. PMID 12188643 DOI: 10.1021/ja0268985  0.84
2002 Salomon CE, Williams DH, Lobkovsky E, Clardy JC, Faulkner DJ. Relative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp. Organic Letters. 4: 1699-702. PMID 12000277 DOI: 10.1021/ol025904z  0.84
2002 Wagenaar MM, Gibson DM, Clardy J. Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis. Organic Letters. 4: 671-3. PMID 11869098 DOI: 10.1021/OL016737Q  0.64
2002 Liu S, Cerione RA, Clardy J. Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proceedings of the National Academy of Sciences of the United States of America. 99: 2743-7. PMID 11867708 DOI: 10.1073/pnas.042454899  0.84
2002 Nonato MC, Widom J, Clardy J. Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2α Journal of Biological Chemistry. 277: 17057-17061. PMID 11859078 DOI: 10.1074/jbc.M111804200  0.84
2001 Brady SF, Bondi SM, Clardy J. The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus. Journal of the American Chemical Society. 123: 9900-1. PMID 11583556 DOI: 10.1021/ja016176y  0.84
2001 Wagenaar MM, Clardy J. Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint. Journal of Natural Products. 64: 1006-9. PMID 11520215 DOI: 10.1021/np010020u  0.64
2001 Wagenaar MM, Clardy J. Two new roridins isolated from Myrothecium sp. The Journal of Antibiotics. 54: 517-20. PMID 11513043 DOI: 10.7164/ANTIBIOTICS.54.517  0.64
2001 Brady SF, Chao CJ, Handelsman J, Clardy J. Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Organic Letters. 3: 1981-4. PMID 11418029 DOI: 10.1021/ol015949k  0.84
2001 Sun HD, Qiu SX, Lobkovsky EB, Lin LZ, Farnsworth NR, Clardy J, Fong HHS. Crystal and molecular structures of a natural equimolecular mixture of two epimeric diterpenes Tetrahedron. 57: 65-70. DOI: 10.1016/S0040-4020(00)00985-6  0.84
2000 Wagenaar MM, Corwin J, Strobel G, Clardy J. Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. Journal of Natural Products. 63: 1692-5. PMID 11141120 DOI: 10.1021/np0002942  0.64
2000 Brady SF, Singh MP, Janso JE, Clardy J. Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Organic Letters. 2: 4047-9. PMID 11112640  0.84
2000 Brady SF, Wagenaar MM, Singh MP, Janso JE, Clardy J. The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Organic Letters. 2: 4043-6. PMID 11112639 DOI: 10.1021/OL006680S  0.84
2000 Brady SF, Clardy J. CR377, a new pentaketide antifungal agent isolated from an endophytic fungus. Journal of Natural Products. 63: 1447-8. PMID 11076576 DOI: 10.1021/np990568p  0.84
2000 Jimenez JI, Yoshida WY, Scheuer PJ, Lobkovsky E, Clardy J, Kelly M. Honulactones: New bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena Journal of Organic Chemistry. 65: 6837-6840. PMID 11030999 DOI: 10.1021/jo991924b  0.84
2000 Rondon MR, August PR, Bettermann AD, Brady SF, Grossman TH, Liles MR, Loiacono KA, Lynch BA, MacNeil IA, Minor C, Tiong CL, Gilman M, Osburne MS, Clardy J, Handelsman J, et al. Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms. Applied and Environmental Microbiology. 66: 2541-7. PMID 10831436 DOI: 10.1128/AEM.66.6.2541-2547.2000  0.84
2000 Singh MP, Janso JE, Luckman SW, Brady SF, Clardy J, Greenstein M, Maiese WM. Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115. The Journal of Antibiotics. 53: 256-61. PMID 10819296 DOI: 10.7164/ANTIBIOTICS.53.256  0.84
2000 Das AK, Bellizzi JJ, Tandel S, Biehl E, Clardy J, Hofmann SL. Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride. The Journal of Biological Chemistry. 275: 23847-51. PMID 10801859 DOI: 10.1074/jbc.M002758200  0.84
2000 Bellizzi JJ, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J. The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proceedings of the National Academy of Sciences of the United States of America. 97: 4573-8. PMID 10781062 DOI: 10.1073/pnas.080508097  0.32
2000 Liu S, Neidhardt EA, Grossman TH, Ocain T, Clardy J. Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure (London, England : 1993). 8: 25-33. PMID 10673429 DOI: 10.1016/S0969-2126(00)00077-0  0.84
2000 Sandler BH, Nikonova L, Leal WS, Clardy J. Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex. Chemistry & Biology. 7: 143-51. PMID 10662696 DOI: 10.1016/S1074-5521(00)00078-8  0.84
2000 Brady SF, Clardy J. Long-chain N-acyl amino acid antibiotics isolated from heterologously expressed environmental DNA [20] Journal of the American Chemical Society. 122: 12903-12904. DOI: 10.1021/ja002990u  0.84
1999 Bellizzi JJ, Widom J, Kemp CW, Clardy J. Producing selenomethionine-labeled proteins with a baculovirus expression vector system. Structure (London, England : 1993). 7: R263-7. PMID 10574801 DOI: 10.1016/S0969-2126(00)80020-9  0.32
1999 Stohl EA, Brady SF, Clardy J, Handelsman J. ZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A. Journal of Bacteriology. 181: 5455-60. PMID 10464220  0.84
1999 Jiang J, Li AH, Jang SY, Chang L, Melman N, Moro S, Ji X, Lobkovsky EB, Clardy JC, Jacobson KA. Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists. Journal of Medicinal Chemistry. 42: 3055-65. PMID 10447949 DOI: 10.1021/jm980688e  0.84
1999 Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J. Structure of the PIN/LC8 dimer with a bound peptide. Nature Structural Biology. 6: 735-40. PMID 10426949 DOI: 10.1038/11501  0.84
1999 Gunasekera SP, McCarthy PJ, Longley RE, Pomponi SA, Wright AE, Lobkovsky E, Clardy J. Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella. Journal of Natural Products. 62: 173-5. PMID 9917313 DOI: 10.1021/np980293y  0.48
1998 Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RA. Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nature Structural Biology. 5: 1047-52. PMID 9846874 DOI: 10.1038/4156  0.84
1998 Emmert EAB, Milner JL, Lee JC, Pulvermacher KL, Olivares HA, Clardy J, Handelsman J. Effect of canavanine from alfalfa seeds on the population biology of bacillus cereus Applied and Environmental Microbiology. 64: 4683-8. PMID 9835549 DOI: 10.1128/aem.64.12.4683-4688.1998  0.36
1998 Handelsman J, Rondon MR, Brady SF, Clardy J, Goodman RM. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chemistry & Biology. 5: R245-9. PMID 9818143  0.84
1998 Liu S, Widom J, Kemp CW, Crews CM, Clardy J. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science (New York, N.Y.). 282: 1324-7. PMID 9812898  0.84
1998 Lee AY, Zhang S, Kongsaeree P, Clardy J, Ganem B, Erickson JW, Xie D. Thermodynamics of a transition state analogue inhibitor binding to Escherichia coli chorismate mutase: probing the charge state of an active site residue and its role in inhibitor binding and catalysis. Biochemistry. 37: 9052-7. PMID 9636050 DOI: 10.1021/bi980217u  0.84
1998 Zhang S, Pohnert G, Kongsaeree P, Wilson DB, Clardy J, Ganem B. Chorismate mutase-prephenate dehydratase from Escherichia coli. Study of catalytic and regulatory domains using genetically engineered proteins. The Journal of Biological Chemistry. 273: 6248-53. PMID 9497350 DOI: 10.1074/jbc.273.11.6248  0.84
1997 Jaspars M, Jackson E, Lobkovsky E, Clardy J, Diaz MC, Crews P. Using scalarane sesterterpenes to examine a sponge taxonomic anomaly. Journal of Natural Products. 60: 556-61. PMID 9214728 DOI: 10.1021/np960147x  0.84
1996 Schroeder DR, Colson KL, Klohr SE, Lee MS, Matson JA, Brinen LS, Clardy J. Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis. The Journal of Antibiotics. 49: 865-72. PMID 8931719 DOI: 10.7164/antibiotics.49.865  0.32
1996 Zhang S, Kongsaeree P, Clardy J, Wilson DB, Ganem B. Site-directed mutagenesis of monofunctional chorismate mutase engineered from the E. coli P-protein. Bioorganic & Medicinal Chemistry. 4: 1015-20. PMID 8831972 DOI: 10.1016/0968-0896(96)00099-5  0.84
1996 Ganesh V, Lee AY, Clardy J, Tulinsky A. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin. Protein Science : a Publication of the Protein Society. 5: 825-35. PMID 8732754 DOI: 10.1002/pro.5560050504  0.84
1996 Milner JL, Silo-Suh L, Lee JC, Haiyin HE, Clardy J, Handelsman JO. Production of kanosamine by Bacillus cereus UW85 Applied and Environmental Microbiology. 62: 3061-3065. PMID 8702302 DOI: 10.1128/AEM.62.8.3061-3065.1996  0.84
1995 Lee AY, Stewart JD, Clardy J, Ganem B. New insight into the catalytic mechanism of chorismate mutases from structural studies. Chemistry & Biology. 2: 195-203. PMID 9383421 DOI: 10.1016/1074-5521(95)90269-4  0.84
1995 Kirst HA, Larsen SH, Paschal JW, Occolowitz JL, Creemer LC, Steiner JL, Lobkovsky E, Clardy J. Structure of the new spiroketal-macrolide A82548A. The Journal of Antibiotics. 48: 990-6. PMID 7592067 DOI: 10.7164/ANTIBIOTICS.48.990  0.84
1995 Concepción GP, Foderaro TA, Eldredge GS, Lobkovsky E, Clardy J, Barrows LR, Ireland CM. Topoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp Journal of Medicinal Chemistry. 38: 4503-4507. PMID 7473578  0.84
1994 Silo-Suh LA, Lethbridge BJ, Raffel SJ, He H, Clardy J, Handelsman J. Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85. Applied and Environmental Microbiology. 60: 2023-30. PMID 8031096 DOI: 10.1128/AEM.60.6.2023-2030.1994  0.36
1994 Fuller RW, Cardellina JH, Jurek J, Scheuer PJ, Alvarado-Lindner B, McGuire M, Gray GN, Steiner JR, Clardy J, Menez E, Robert S, Newman DJ, Snader KM, Boyd MR. Isolation and structure/activity features of halomon-related antitumor monoterpenes from the red alga portieria hornemannii Journal of Medicinal Chemistry. 37: 4407-4411. PMID 7996553 DOI: 10.1021/JM00051A019  0.84
1994 McWilliams JC, Clardy J. Total synthesis of (+)-octalactins A and B: Unusual metabolites from a marine microbe Journal of the American Chemical Society. 116: 8378-8379. DOI: 10.1021/ja00097a060  0.84
1994 Ikeda Y, Schultz LW, Clardy J, Schreiber SL. Structural basis for peptidomimicry by a natural product Journal of the American Chemical Society. 116: 4143-4144. DOI: 10.1021/ja00088a086  0.84
1994 Schultz LW, Martin PK, Liang J, Schreiber SL, Clardy J. Atomic structure of the immunophiln FKBP13-FK506 complex: Insights into the composite binding surface for calcineurin Journal of the American Chemical Society. 116: 3129-3130. DOI: 10.1021/ja00086a055  0.84
1994 Lee AY, Clardy J. Structure of the trypsin-cyclotheonamide A complex: an all-natural approach Chemistry and Biology. 1. DOI: 10.1016/1074-5521(94)90022-1  0.84
1994 Garson MJ, Jones DD, Small CJ, Liang J, Clardy J. Biosynthetic studies on polypropionates: A stereochemical model for siphonarins A and B from the pulmonate limpet siphonaria zelandica Tetrahedron Letters. 35: 6921-6924. DOI: 10.1016/0040-4039(94)85042-9  0.84
1993 Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin Journal of Molecular Biology. 229: 105-124. PMID 7678431  0.84
1993 Mantus EK, Clardy J. The synthesis of dithyreanitrile Tetrahedron Letters. 34: 1085-1086. DOI: 10.1016/S0040-4039(00)77496-X  0.84
1992 Ayer WA, Sun M, Browne LM, Brinen LS, Clardy J. Chemical investigation of the metabolites from the Canadian tuckahoe, Polyporus tuberaster. Journal of Natural Products. 55: 649-53. PMID 1517736  0.32
1992 Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MR. A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. Journal of Medicinal Chemistry. 35: 3007-11. PMID 1501227  0.84
1992 Delgado A, Clardy J. Aryl trifluoromethyl ketone hydrates as precursors of carboxylic acids and esters1 Tetrahedron Letters. 33: 2789-2790. DOI: 10.1016/S0040-4039(00)78858-7  0.84
1992 Kimura Y, Nishibe M, Nakajima H, Hamasaki T, Shigemitsu N, Sugawara F, Stout TJ, Clardy J. Emeniveol; A new pollen growth inhibitor from the fungus, Emericella nivea Tetrahedron Letters. 33: 6987-6990. DOI: 10.1016/S0040-4039(00)60913-9  0.84
1992 Leet JE, Golik J, Hofstead SJ, Matson JA, Lee AY, Clardy J. Kedarcidin chromophore: Structure elucidation of the amino sugar kedarosamine Tetrahedron Letters. 33: 6107-6110. DOI: 10.1016/S0040-4039(00)60018-7  0.84
1992 Golik J, Krishnan B, Doyle TW, VanDuyne G, Clardy J. Stereochemical studies on esperamicins: The absolute configuration of their bicyclic aglycone Tetrahedron Letters. 33: 6049-6052. DOI: 10.1016/S0040-4039(00)60003-5  0.84
1992 McDonald LA, Foster MP, Phillips DR, Ireland CM, Lee AY, Clardy J. Tawicyclamides A and B, new cyclic peptides from the ascidian Lissoclinum patella: Studies on the solution- and solid-state conformations Journal of Organic Chemistry. 57: 4616-4624.  0.84
1991 Powell RG, Mikolajczak KL, Zilkowski BW, Mantus EK, Cherry D, Clardy J. Limonoid antifeedants from seed of Sandoricum koetjape. Journal of Natural Products. 54: 241-6. PMID 2045819 DOI: 10.1021/NP50073A025  0.84
1991 Powell RG, Mikolajczak KL, Zilkowski BW, Lu HS, Mantus EK, Clardy J. Dithyreanitrile: an unusual insect antifeedant from Dithyrea wislizenii. Experientia. 47: 304-6. PMID 2009944 DOI: 10.1007/BF01958168  0.84
1991 Atta-ur-Rahman, Alvi KA, Abbas SA, Sultana T, Shameel M, Choudhary MI, Clardy JC. A diterpenoid lactone from Aplysia juliana. Journal of Natural Products. 54: 886-8. PMID 1955886  0.84
1991 Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clarpy J. Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex Science. 252: 839-842. PMID 1709302  0.88
1991 Kobayashi J, Cheng JF, Nakamura H, Ohizumi Y, Tomotake Y, Matsuzaki T, Grace KJ, Jacobs RS, Kato Y, Brinen LS. Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp. Experientia. 47: 501-2. PMID 1675176 DOI: 10.1007/BF01959955  0.84
1990 LaLonde RT, Perakyla H, Ishiguro Y, Clardy J, Brinen LS. Structure of an anhydride related to a mutagenic component of drinking water, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. Chemical Research in Toxicology. 3: 404-5. PMID 2133090  0.32
1990 Golik J, Doyle TW, Van Duyne G, Clardy J. Stereochemical studies on esperamicin A1: A single crystal x-ray structure of thiosugar moiety Tetrahedron Letters. 31: 6149-6150. DOI: 10.1016/S0040-4039(00)97010-2  0.84
1990 Zabriskie TM, Foster MP, Stout TJ, Clardy J, Ireland CM. Studies on the solution- and solid-state structure of patellin 2 Journal of the American Chemical Society. 112: 8080-8084.  0.84
1990 Forsyth CJ, Clardy J. Total syntheses of (+)- and (-)-didemnenones A and B. Antiselectivity in the intramolecular carbomercuration reaction Journal of the American Chemical Society. 112: 3497-3505.  0.84
1989 Coll JC, Bowden BF, Heaton A, Scheuer PJ, Li MK, Clardy J, Schulte GK, Finer-Moore J. Structures and possible functions of epoxypukalide and pukalide : Diterpenes associated with eggs of sinularian soft corals (Cnidaria, Anthozoa, Octocorallia, Alcyonacea, Alcyoniidae). Journal of Chemical Ecology. 15: 1177-91. PMID 24272003 DOI: 10.1007/BF01014821  0.84
1989 Kernan MR, Faulkner DJ, Parkanyi L, Clardy J, de Carvalho MS, Jacobs RS. Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp.. Experientia. 45: 388-90. PMID 2707379 DOI: 10.1007/BF01957489  0.84
1988 Yamashita M, Uchimura M, Iida A, Parkanayi L, Clardy J. A novel stereocontrolled preparation of phospho sugar derivatives from phospholenes Journal of the Chemical Society, Chemical Communications. 569-570. DOI: 10.1039/C39880000569  0.84
1988 Atta-Ur-Rahman, Ahmad VU, Bano S, Abbas SA, Alvi KA, Ali MS, Lu HM, Clardy J. Pinnatazane, a bridged cyclic ether sesquiterpene from Laurencia pinnatifida Phytochemistry. 27: 3879-3880. DOI: 10.1016/0031-9422(88)83036-X  0.84
1988 Lindquist N, Fenical W, Sesin DF, Ireland CM, Van Duyne GD, Forsyth CJ, Clardy J. Isolation and structure determination of the didemnenones, novel cytotoxic metabolites from tunicates Journal of the American Chemical Society. 110: 1308-1309.  0.84
1988 Sugawara F, Takahashi N, Strobel GA, Strobel SA, Lu HSM, Clardy J. Triticones A and B, novel phytotoxins from the plant pathogenic fungus Drechslera tritici-repentis Journal of the American Chemical Society. 110: 4086-4087.  0.84
1987 Talluri S, Montelione GT, Van Duyne G, Piela L, Clardy J, Scheraga HA. Conformational properties of 2,4-methanoproline (2-carboxy-2,4-methanopyrrolidine) in peptides: evidence for 2,4-methanopyrrolidine asymmetry based on solid-state x-ray crystallography, proton NMR in aqueous solution, and CNDO/2 conformational energy calculations Journal of the American Chemical Society. 109: 4473-4477. DOI: 10.1021/ja00249a008  0.76
1987 Cardellina JH, Hendrickson RL, Manfredi KP, Strobel SA, Clardy J. Bissetone, a unique antimicrobial pyranone from the gorgonian Briareu polyanthes Tetrahedron Letters. 28: 727-730. DOI: 10.1016/S0040-4039(01)80973-4  0.84
1987 Higa T, Okuda RK, Severns RM, Scheuer PJ, He CH, Changfu X, Clardy J. Unprecedented constituents of a new species of acorn worm Tetrahedron. 43: 1063-1070. DOI: 10.1016/S0040-4020(01)90042-0  0.84
1987 Hrovat DA, Miyake F, Trammell G, Gilbert KE, Mitchell J, Clardy J, Borden WT. Synthesis of 10-selenatricyclo[3.3.3.03,7]undec-3(7)-ene. X-ray structure of an alkene containing a pyramidalized double bond [4] Journal of the American Chemical Society. 109: 5524-5526.  0.84
1987 Golik J, Clardy J, Dubay G, Groenewold G, Kawaguchi H, Konishi M, Krishnan B, Ohkuma H, Saitoh KI, Doyle TW. Esperamicins, a novel class of potent antitumor antibiotics. 2. Structure of esperamicin X Journal of the American Chemical Society. 109: 3461-3462.  0.84
1986 Smitka TA, Bunge RH, Wilton JH, Hokanson GC, French JC, He CH, Clardy J. PD 116,152, a new phenazine antitumor antibiotic structure and antitumor activity Journal of Antibiotics. 39: 800-803. PMID 3755428 DOI: 10.7164/ANTIBIOTICS.39.800  0.84
1986 Look SA, Fenical W, Jacobs RS, Clardy J. The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae. Proceedings of the National Academy of Sciences of the United States of America. 83: 6238-40. PMID 2875457  0.84
1986 Montelione GT, Hughes P, Clardy J, Scheraga HA. Conformational properties of 2,4-methanoproline (2-carboxy-2,4-methanopyrrolidine) in peptides: determination of preferred peptide bond conformation in aqueous solution by proton Overhauser measurements Journal of the American Chemical Society. 108: 6765-6773. DOI: 10.1021/ja00281a051  0.76
1986 Gerwick WH, Lopez A, Van Duyne GD, Clardy J, Ortiz W, Baez A. Hormothamnione, a novel cytotoxic styrylchromone from the marine cyanophyte hormothamnion enteromorphoides grunow Tetrahedron Letters. 27: 1979-1982. DOI: 10.1016/S0040-4039(00)84426-3  0.84
1986 Shimizu Y, Chou HN, Bando H, Van Duyne G, Clardy JC. Structure of brevetoxin a (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus breris) Journal of the American Chemical Society. 108: 514-515.  0.84
1986 Zabriskie TM, Klocke JA, Ireland CM, Marcus AH, Molinski TF, Faulkner DJ, Xu C, Clardy JC. Jaspamide, a modified peptide from a Jaspis sponge, with insecticidal and antifungal activity Journal of the American Chemical Society. 108: 3123-3124.  0.84
1986 McMurry JE, Haley GJ, Matz JR, Clardy JC, Van Duyne G, Gleiter R, Schäfer W, White DH. Synthesis and chemistry of tetracyclo[8.2.2.22,5.26,9]-1,5,9-octadecatriene Journal of the American Chemical Society. 108: 2932-2938.  0.84
1986 Shimizu Y, Bando H, Chou HN, Van Duyne G, Clardy JC. Absolute configuration of brevetoxins Journal of the Chemical Society, Chemical Communications. 1656-1658.  0.84
1986 McMurry JE, Haley GJ, Matz JR, Clardy JC, Mitchell J. Pentacyclo[12.2.2.22,5.26,9.2 10,13]-1,5,9,13-tetracosatetraene and its reaction with AgOTf. Synthesis of a square-planar d10 organometallic complex Journal of the American Chemical Society. 108: 515-516.  0.84
1985 Sugawara F, Strobel G, Fisher LE, Van Duyne GD, Clardy J. Bipolaroxin, a selective phytotoxin produced by Bipolaris cynodontis. Proceedings of the National Academy of Sciences of the United States of America. 82: 8291-4. PMID 3866223 DOI: 10.1073/PNAS.82.24.8291  0.84
1985 Montelione G, Arnold E, Meinwald Y, Stimson E, Denton J, Huang S, Clardy J, Scheraga H. Additions and Corrections - Chain-Folding Initiation Structures in Ribonuclease A: Conformational Analysis of trans-Ac-Asn-Pro-Tyr NHMe and trans-Ac-Tyr-Pro-Asn-NHMe in Water and in the Solid State Journal of the American Chemical Society. 107: 1457-1457. DOI: 10.1021/ja00291a602  1
1985 Pearson AJ, Khan MNI, Clardy JC, Cun-heng H. Stereocontrolled functionalization in the cyclohexane ring using organomolybdenum chemistry Journal of the American Chemical Society. 107: 2748-2757.  0.84
1984 Robeson D, Strobel G, Matusumoto GK, Fisher EL, Chen MH, Clardy J. Alteichin: an unusual phytotoxin from Alternaria eichorniae, a fungal pathogen of water hyacinth. Experientia. 40: 1248-50. PMID 6548712 DOI: 10.1007/BF01946657  0.84
1984 Montelione GT, Arnold E, Meinwald YC, Stimson ER, Denton JB, Huang SG, Clardy J, Scheraga HA. Chain-folding initiation structures in ribonuclease A: conformational analysis of trans-Ac-Asn-Pro-Tyr-NHMe and trans-Ac-Tyr-Pro-Asn-NHMe in water and in the solid state Journal of the American Chemical Society. 106: 7959-7969. DOI: 10.1021/ja00337a052  1
1984 Hauser FM, Ellenberger SR, Clardy JC, Bass LS. Sulfoxide-mediated intramolecular hydroxylation of a remote olefin in an acyclic system Journal of the American Chemical Society. 106: 2458-2459.  0.84
1984 McMurry JE, Haley GJ, Matz JR, Clardy JC, Van Duyne G, Gleiter R, Schäfer W, White DH. Tetracyclo[8.2.2.22,5.26,9]octadeca-1,5,9-triene Journal of the American Chemical Society. 106: 5018-5019.  0.84
1981 Balitz DM, O'Herron FA, Bush J, Vyas DM, Nettleton DE, Grulich RE, Bradner WT, Doyle TW, Arnold E, Clardy J. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. The Journal of Antibiotics. 34: 1544-55. PMID 7344705  0.32
1981 Pinhas AR, Samuelson AG, Risemberg R, Arnold EV, Clardy J, Carpenter BK. Experimental evidence for orbital symmetry control of stereochemistry in some (methylenecyclopropane)iron-carbonyl reactions Journal of the American Chemical Society. 103: 1668-1675.  0.84
1980 Grieco PA, Owens W, Wang CL, Williams E, Schillinger WJ, Hirotsu K, Clardy J. Fluoroprostaglandins: synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-, (-)-ent-12-fluoro-, (+)-15-epi-fluoro-, and (-)-ent-15 epi-12-fluoroprostaglandin F2 alpha. Journal of Medicinal Chemistry. 23: 1072-7. PMID 7420351  0.84
1980 Toth JA, Jay Burreson B, Scheuer PJ, Finer-Moore J, Clardy J. Emblide, a new polyfunctional cembranolide from the soft coral sarcophyton glaucum Tetrahedron. 36: 1307-1309. DOI: 10.1016/0040-4020(80)85041-1  0.84
1979 Kinnel RB, Dieter RK, Meinwald J, Van Engen D, Clardy J, Eisner T, Stallard MO, Fenical W. Brasilenyne and cis-dihydrorhodophytin: Antifeedant medium-ring haloethers from a sea hare (Aplysia brasiliana). Proceedings of the National Academy of Sciences of the United States of America. 76: 3576-9. PMID 16592687 DOI: 10.1073/pnas.76.8.3576  0.36
1979 Gassman PG, Korn SR, Bailey TF, Johnson TH, Finer J, Clardy J. The synthesis and structure of 10,11-bistrifluoromethyl-i,o-bicyclo[7.2.2]trideca-10,12-diene. A highly strained inside-outside bicycloalkane derivative Tetrahedron Letters. 20: 3401-3404. DOI: 10.1016/S0040-4039(01)95420-6  0.84
1979 Kende AS, Benechie M, Curran DP, Fludzinski P, Swenson W, Clardy J. The dichlorovinylation of enolates Tetrahedron Letters. 20: 4513-4516. DOI: 10.1016/S0040-4039(01)86636-3  0.84
1979 Yamashita M, Nakatsukasa Y, Yoshida H, Ogata T, Inokawa S, Hirotsu K, Clardy J. Synthesis of 5,6-dideoxy-3-O-methyl-5-C-(phenylphosphinyl)-d-glucopyranose and its 1,2,4-triacetate Carbohydrate Research. 70: 247-261. DOI: 10.1016/S0008-6215(00)87105-0  0.84
1978 Baldwin JE, Herchen SR, Clardy JC, Hirotsu K, Chou TS. Preparation of 6β-imidopenicillinate 1(S)-oxides Journal of Organic Chemistry. 43: 1342-1346.  0.84
1978 Templeton JL, Dorman WC, Clardy JC, McCarley RE. Synthesis and characterization of new metal-metal bonded species. 2. Crystal and molecular structure of dimeric niobium(III) and tantalum(III) bromide adducts with tetrahydrothiophene. Direct stereochemical evidence of bonding electron density in confacial bioctahedra with metal-metal double bonds Inorganic Chemistry. 17: 1263-1267.  0.84
1978 Semmelhack MF, Weller HN, Clardy J. Rapid vinyl shifts in spiro[4.4]polyenes: Verification of the rate-determining step and the identity of the migrating group Journal of Organic Chemistry. 43: 3791-3792.  0.84
1977 Sun HH, Waraszkiewicz SM, Erickson KL, Finer KL, Clardy J. Dictyoxepin and dictyolene, two new diterpenes from the marine alga Dictyota acutiloba (Phaeophyta) Journal of the American Chemical Society. 99: 3516-3517. PMID 853193 DOI: 10.1021/JA00452A062  0.84
1977 Cole RJ, Kirksey JW, Dorner JW, Wilson DM, Johnson JC, Johnson AN, Bedell DM, Springer JP, Chexal KK, Clardy JC, Cox RH. Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage. Journal of Agricultural and Food Chemistry. 25: 826-30. PMID 328548  0.84
1977 Wratten SJ, Faulkner DJ, Hirotsu K, Clardy J. Trimethylenemethane. A reversible, temperature dependent transformation from higher to lower symmetry as observed by electron spin resonance spectroscopy. Journal of the American Chemical Society. 99: 2824-5. PMID 14985 DOI: 10.1021/JA00450A083  0.48
1977 Albright JO, Clardy JC, Verkade JG. Crystal and molecular structure of pentakis(4-methyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane)cobalt(I) (acetonitrile)trinitratocobalt(II), {Co[P(OCH2)3CMe]5}[Co(NO3) 3NCMe] Inorganic Chemistry. 16: 1575-1580.  0.84
1977 Clardy JC, Milbrath DS, Verkade JG. Characterization and molecular structure of S=P(OCH2CH2)3N. Trigonal planarity of nitrogen [19] Journal of the American Chemical Society. 99: 631-633.  0.84
1977 Clardy JC, Milbrath DS, Verkade JG. Unusual phosphorus basicity of P(OCH2CH2)3N and the molecular structure of H3BP(OCH2CH2)3N Inorganic Chemistry. 16: 2135-2137.  0.84
1977 Fayos J, Clardy J, Dolby LJ, Farnham T. The chemistry of γ-oxo sulfones. 1. A novel rearrangement and a method for the β-alkylation of α,β-unsaturated ketones Journal of Organic Chemistry. 42: 1349-1352.  0.84
1976 Prestwich GD, Tanis SP, Springer JP, Clardy J. Letter: Nasute termite soldier frontal gland secretions. 1. Structure of trinervi-2 beta, 3 alpha, 9 alpha-triol 9-o-acetate, a novel diterpene fromTrinervitermes soldiers. Journal of the American Chemical Society. 98: 6061-2. PMID 965639 DOI: 10.1021/ja00435a060  0.84
1976 Ireland C, Faulkner DJ, Finer J, Clardy J. Letter: A novel diterpene from Dollabella californica. Journal of the American Chemical Society. 98: 4664-5. PMID 932371 DOI: 10.1021/ja00431a063  0.48
1976 Springer JP, Clardy J, Wells JM, Cole RJ, Kirksey JW, Macfarlane RD, Torgerson DF. Isolation and structure determination of the mycotoxin chaetoglobosin C, a new [13] cytochalasin Tetrahedron Letters. 17: 1355-1358. DOI: 10.1016/S0040-4039(00)78063-4  0.84
1976 Burke BA, Chan WR, Prince EC, Manchand PS, Eickman N, Clardy J. The structure of corylifuran, A clerodane-type diterpene from Croton corylifolius lam Tetrahedron. 32: 1881-1884. DOI: 10.1016/0040-4020(76)85190-3  0.84
1976 Milbrath DS, Springer JP, Clardy JC, Verkade JG. Phosphorus ester basicity dependence on constraint. Crystal and molecular structures of P(OCH2)3CCH2Br and O=P(OCH2)2C(CH3)O Journal of the American Chemical Society. 98: 5493-5496.  0.84
1976 Clardy JC, Milbrath DS, Springer JP, Verkade JG. Characterization and molecular structure of [HP(OCH2CH2)3N]BF4. Pentacoordination of phosphorus [12] Journal of the American Chemical Society. 98: 623-624.  0.84
1975 Anderson GD, Powers TJ, Djerassi C, Fayos J, Clardy J. A stereoselective synthesis of two stereoisomers of demethylgorgosterol. Journal of the American Chemical Society. 97: 388-94. PMID 1133356 DOI: 10.1021/JA00835A029  0.44
1975 Lisy JM, Clardy J, Anchel M, Weinreb SM. X-Ray structure of phlebiakauranol and phlebianorkauranol, highly oxygenated antibacterial metabolites of Phlebia strigosozonata Journal of the Chemical Society, Chemical Communications. 406-407. DOI: 10.1039/C39750000406  0.84
1975 Warner PM, LaRose RC, Palmer RF, Lee CM, Ross DO, Clardy JC. Propellanes. X. The dimerization of 9,9-dichlorotricyclo[4.2.1.01.6]non-3-ene Journal of the American Chemical Society. 97: 5507-5512. DOI: 10.1021/JA00852A031  0.84
1975 Meiners JH, Rix CJ, Clardy JC, Verkade JG. Preparation, properties, and crystal structure of a cationic nickel nitrosyl bicyclic phosphite complex Inorganic Chemistry. 14: 705-710.  0.84
1975 Vande Griend LJ, Clardy JC, Verkade JG. Crystal and molecular structure of diiodotris(trimethyl phosphite)nickel(II), NiI2[P(OCH3)3]3 Inorganic Chemistry. 14: 710-714.  0.84
1975 Meiners JH, Clardy JC, Verkade JG. Crystal and molecular structure of [Ag(P(OMe)3)2NO3]2. A case of symmetric nitrate-oxygen bridging Inorganic Chemistry. 14: 632-636.  0.84
1975 Milbrath DS, Springer JP, Clardy JC, Verkade JG. Crystal and molecular structure of bromotetrakis(trimethyl phosphito)nickel(II) tetrafluoroborate, {Ni[P(OCH3)3]4Br}BF4 Inorganic Chemistry. 14: 2665-2668.  0.84
1974 Swenton JS, Hyatt JA, Lisy JM, Clardy J. Photochemical cycloadditions of triplet 1,3-dimethyluracil to olefins. Structural studies on the adducts Journal of the American Chemical Society. 96: 4885-4891. PMID 4853623 DOI: 10.1021/JA00822A028  0.84
1974 Springer JP, Clardy J, Cole RJ, Kirksey JW, Hill RK, Carlson MR, Isidor JL. Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin. Journal of the American Chemical Society. 96: 2267-8. PMID 4833647 DOI: 10.1021/JA00814A055  0.84
1974 Kroening RF, Rush RM, Martin DS, Clardy JC. Polarized crystal absorption spectra and crystal structure for potassium tetrabromoplatinate(II) Inorganic Chemistry. 13: 1366-1373.  0.84
1973 Hall SS, Faulkner DJ, Fayos J, Clardy J. Oppositol, a brominated sesquiterpene alcohol of a new skeletal class from the red alga, Laurencia subopposita. Journal of the American Chemical Society. 95: 7187-9. PMID 4789148 DOI: 10.1021/ja00802a064  0.84
1973 Büchi G, Kitaura Y, Yuan SS, Wright HE, Clardy J, Demain AL, Ginsukon T, Hunt N, Wogan GN. Letter: structure of cytochalasin E, a toxic metabolite of Aspergillus clavatus. Journal of the American Chemical Society. 95: 5423-5. PMID 4733808  0.84
1973 Kende AS, Fayos J, Belletire JL, Clardy JC, Herrmann JL, Romanet RF, Hume EL, Schlessinger RH. Regiospecific Construction of Polyoxygenated 9,10-Anthraontncnes. Total Synthesis of Islandicin and Digitopurpone Synthetic Communications. 3: 387-392. DOI: 10.1080/00397917308065929  0.44
1973 Porter SK, White H, Green CR, Angelici RJ, Clardy J. X-ray crystallographic determination of the molecular structure of bis-(μ-NN-dimethylthiocarbamoyl)-bis[chloro(trimethyl phosphite)palladium(II) ] Journal of the Chemical Society, Chemical Communications. 493-494. DOI: 10.1039/C39730000493  0.84
1973 Chapman OL, Clardy JC, McDowell TL, Wright HE. Photoisomerization of 5,5-dimethylbicyclo[4.1.0]hept-3-en-2-one and 4,6,6-trimethylbicyclo[3.1.0]hex-3-en-2-one [30] Journal of the American Chemical Society. 95: 5086-5087.  0.84
1973 Kroening RF, Hunter LD, Rush RM, Clardy JC, Martin DS. Polarized electronic crystal absorption spectra of dibromo(ethylenediamine)platinum(II) Journal of Physical Chemistry. 77: 3077-3080.  0.84
1972 Clardy JC, Mosbo JA, Verkade JG. Crystal and molecular structure of cyclophosphamide hydrate Journal of the Chemical Society, Chemical Communications. 1163b-1164. DOI: 10.1039/C3972001163b  0.84
1972 Clardy J, Barton TJ. A novel solid-state molecular complex of diphenylacetylene and 1,1-dimethyl-2,5-diphenyl-1-silacyclopentadiene Journal of the Chemical Society, Chemical Communications. 690-691. DOI: 10.1039/C39720000690  0.84
1972 Paquette LA, Lang SA, Short MR, Parkinson B, Clardy J. Stereochemistry of the stereoselective epoxidation and hydroboration of hexamethyl (Dewar benzene) Tetrahedron Letters. 13: 3141-3144. DOI: 10.1016/S0040-4039(01)93986-3  0.84
1972 Paquette LA, Lang SA, Porter SK, Clardy J. Hydration of hexamethyl (Dewar benzene) oxide. Stereochemical aspects of the resulting rearrangement Tetrahedron Letters. 13: 3137-3140. DOI: 10.1016/S0040-4039(01)93985-1  0.84
1972 Gougoutas JZ, Clardy JC. Solid-state chemistry of organic polyvalent iodine compounds. I. The crystal structures of two polymorphs of 1-(2′-iodobenzoyloxy)-1,2-benziodoxolin-3-one Journal of Solid State Chemistry. 4: 230-242. DOI: 10.1016/0022-4596(72)90111-9  0.84
1972 Gougoutas JZ, Clardy JC. Solid-state coordination bonding to polyvalent iodine-The structure of 1-acetoxy-1,2-benziodoxolin-3-one Journal of Solid State Chemistry. 4: 226-229. DOI: 10.1016/0022-4596(72)90110-7  0.84
1972 Jolley WH, Smith ED, Martin DS, Clardy JC, Woods JD. trans-dibromodiammineplatinum(II). Aquation and isotopic exchange of bromide ligands with free bromide and with tetrabromoplatinate(II) Inorganic Chemistry. 11: 2866-2872.  0.84
1972 Warner P, LaRose R, Lee CM, Clardy JC. Spontaneous generation of a bridgehead double bond in a seven-membered ring [24] Journal of the American Chemical Society. 94: 7607-7609.  0.84
1971 Ozbirn WP, Jacobson RA, Clardy JC. Crystal and molecular structure of 1,2,5-triphenylphosphole Journal of the Chemical Society D: Chemical Communications. 1062. DOI: 10.1039/C29710001062  0.84
1971 Ma KW, Chang FC, Clardy JC. X-Ray crystal and molecular structure of the triterpenoid 24,25-dibromokulactone Journal of the Chemical Society D: Chemical Communications. 424-425. DOI: 10.1039/C29710000424  0.84
1971 Chapman OL, McIntosh CL, Clardy JC. Synthesis of substituted α-methylene lactones: Determination of product structure by X-ray crystallography Journal of the Chemical Society D: Chemical Communications. 384-385. DOI: 10.1039/C29710000384  0.84
1971 Trahanovsky WS, Ong CC, Pataky JG, Weitl FL, Mullen PW, Clardy JC, Hansen RS. Organic oxalates. VI. Pyrolysis of di(α-substituted benzyl) oxalates Journal of Organic Chemistry. 36: 3575-3579.  0.84
1971 Clardy JC, McEwen GK, Mosbo JA, Verkade JG. The structure of the product obtained from an unusual phosphine halogenation reaction Journal of the American Chemical Society. 93: 6937-6940.  0.84
1971 Chapman OL, Engel MR, Springer JP, Clardy JC. The total synthesis of carpanone [18] Journal of the American Chemical Society. 93: 6696-6698.  0.84
1970 Lee CM, Clardy JC. Crystal and molecular structure of 4-methylsulphonoxyadamantanone Journal of the Chemical Society D: Chemical Communications. 716-717. DOI: 10.1039/C29700000716  0.84
1970 Barton TJ, Rogido R, Clardy JC. Stepwise addition of chlorosulfonyl isocyanate to cyclopropenes Tetrahedron Letters. 11: 2081-2084. DOI: 10.1016/S0040-4039(01)98159-6  0.84
1970 Clardy JC, Wildman WC, Hauser FM. Crystal and molecular structure of narcissidine [15] Journal of the American Chemical Society. 92: 1781-1782.  0.84
1970 Clardy J, Hauser FM, Dahm D, Jacobson RA, Wildman WC. Molecular structure and absolute configuration of alkaloids related to 5,10-ethanophenanthridine [8] Journal of the American Chemical Society. 92: 6337-6339.  0.84
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