Yit-Heng Chooi, Ph.D. - Publications

2015- School of Molecular Sceinces University of Western Australia, Crawley, Western Australia, Australia 
Fungal natural product biosynthesis and microbial genome mining

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gilchrist CLM, Lacey HJ, Vuong D, Pitt JI, Lange L, Lacey E, Pilgaard B, Chooi YH, Piggott AM. Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov. Fungal Genetics and Biology : Fg & B. 103435. PMID 32702474 DOI: 10.1016/j.fgb.2020.103435  0.32
2020 Kong L, Wang Q, Yang W, Shen J, Li Y, Zheng X, Wang L, Chu Y, Deng Z, Chooi YH, You D. Three recently diverging duplicated methyltransferases exhibit substrate-dependent regioselectivity essential for xantholipin biosynthesis. Acs Chemical Biology. PMID 32649177 DOI: 10.1021/acschembio.0c00296  0.72
2020 Lacey HJ, Booth TJ, Vuong D, Rutledge PJ, Lacey E, Chooi YH, Piggott AM. Conglobatins B-E: cytotoxic analogues of the C-symmetric macrodiolide conglobatin. The Journal of Antibiotics. PMID 32555501 DOI: 10.1038/s41429-020-0332-3  0.32
2020 Roux I, Woodcraft C, Hu J, Wolters R, Gilchrist CLM, Chooi YH. CRISPR-mediated activation of biosynthetic gene clusters for bioactive molecule discovery in filamentous fungi. Acs Synthetic Biology. PMID 32526136 DOI: 10.1021/acssynbio.0c00197  0.32
2020 Li H, Gilchrist CLM, Phan CS, Lacey HJ, Vuong D, Moggach SA, Lacey E, Piggott AM, Chooi YH. Biosynthesis of a New Benzazepine Alkaloid Nanangelenin A from Involves an Unusual L-Kynurenine-Incorporating NRPS Catalyzing Regioselective Lactamization. Journal of the American Chemical Society. PMID 32182055 DOI: 10.1021/jacs.0c01605  0.32
2019 Li H, Wei H, Hu J, Lacey E, Sobolev AN, Stubbs KA, Solomon PS, Chooi YH. Genomics-driven Discovery of Phytotoxic Cytochalasans involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum. Acs Chemical Biology. PMID 31815421 DOI: 10.1021/acschembio.9b00791  0.32
2019 Lacey HJ, Gilchrist CLM, Crombie A, Kalaitzis JA, Vuong D, Rutledge PJ, Turner P, Pitt JI, Lacey E, Chooi YH, Piggott AM. Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, . Beilstein Journal of Organic Chemistry. 15: 2631-2643. PMID 31807198 DOI: 10.3762/bjoc.15.256  0.32
2019 Rawlinson C, See PT, Moolhuijzen P, Li H, Moffat CS, Chooi YH, Oliver RP. The identification and deletion of the PKS-NRPS gene responsible for production of the phytotoxic Triticone A/B in wheat fungal pathogen Pyrenophora tritici-repentis. Environmental Microbiology. PMID 31698543 DOI: 10.1111/1462-2920.14854  0.32
2019 Li H, Hu J, Wei H, Solomon PS, Stubbs KA, Chooi YH. Biosynthesis of a Tricyclo[,7]dodecane System by a Berberine Bridge Enzyme-like Intramolecular Aldolase. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31553484 DOI: 10.1002/chem.201904360  0.32
2019 Phan CS, Li H, Kessler S, Solomon PS, Piggott AM, Chooi YH. Bipolenins K-N: New sesquiterpenoids from the fungal plant pathogen . Beilstein Journal of Organic Chemistry. 15: 2020-2028. PMID 31501669 DOI: 10.3762/bjoc.15.198  0.32
2019 Urquhart AS, Hu J, Chooi YH, Idnurm A. The fungal gene cluster for biosynthesis of the antibacterial agent viriditoxin. Fungal Biology and Biotechnology. 6: 2. PMID 31304040 DOI: 10.1186/s40694-019-0072-y  0.32
2019 Hu J, Li H, Chooi YH. A Fungal Dirigent Protein Controls the Stereoselectivity of Multicopper Oxidase-Catalyzed Phenol Coupling in Viriditoxin Biosynthesis. Journal of the American Chemical Society. PMID 31045362 DOI: 10.1021/jacs.9b03354  0.32
2019 Hu J, Sarrami F, Li H, Zhang G, Stubbs KA, Lacey E, Stewart SG, Karton A, Piggott AM, Chooi YH. Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system. Chemical Science. 10: 1457-1465. PMID 30809363 DOI: 10.1039/c8sc02870b  0.32
2019 Li H, Gilchrist CLM, Lacey HJ, Crombie A, Vuong D, Pitt JI, Lacey E, Chooi YH, Piggott AM. Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii. Organic Letters. PMID 30735051 DOI: 10.1021/acs.orglett.8b04042  0.32
2018 Li H, Hu J, Wei H, Solomon PS, Vuong D, Lacey E, Stubbs KA, Piggott AM, Chooi YH. Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum. Organic Letters. PMID 30226784 DOI: 10.1021/acs.orglett.8b02617  0.32
2018 Gilchrist CLM, Li H, Chooi YH. Panning for gold in mould: can we increase the odds for fungal genome mining? Organic & Biomolecular Chemistry. PMID 29393329 DOI: 10.1039/c7ob03127k  0.32
2017 Yap HY, Muria-Gonzalez MJ, Kong BH, Stubbs KA, Tan CS, Ng ST, Tan NH, Solomon PS, Fung SY, Chooi YH. Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast. Microbial Cell Factories. 16: 103. PMID 28606152 DOI: 10.1186/s12934-017-0713-x  0.32
2017 Liu N, Hung YS, Gao SS, Hang L, Zou Y, Chooi YH, Tang Y. Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Organic Letters. PMID 28605916 DOI: 10.1021/acs.orglett.7b01534  1
2017 Pitt JI, Lange L, Lacey AE, Vuong D, Midgley DJ, Greenfield P, Bradbury MI, Lacey E, Busk PK, Pilgaard B, Chooi YH, Piggott AM. Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils. Plos One. 12: e0170254. PMID 28379953 DOI: 10.1371/journal.pone.0170254  0.32
2017 Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D. Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps. Proceedings of the National Academy of Sciences of the United States of America. PMID 28373542 DOI: 10.1073/pnas.1701361114  0.52
2017 Chooi YH, Zhang G, Hu J, Muria-Gonzalez MJ, Tran P, Pettitt A, Maier A, Barrow RA, Solomon PS. Functional genomics-guided discovery of a light-activated phytotoxin in the wheat pathogen Parastagonospora nodorum via pathway activation. Environmental Microbiology. PMID 28251756 DOI: 10.1111/1462-2920.13711  0.32
2016 Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D. A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation. Cell Chemical Biology. 23: 508-516. PMID 27105283 DOI: 10.1016/j.chembiol.2016.03.013  1
2015 Yap HY, Chooi YH, Fung SY, Ng ST, Tan CS, Tan NH. Transcriptome Analysis Revealed Highly Expressed Genes Encoding Secondary Metabolite Pathways and Small Cysteine-Rich Proteins in the Sclerotium of Lignosus rhinocerotis. Plos One. 10: e0143549. PMID 26606395 DOI: 10.1371/journal.pone.0143549  1
2015 Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi YH, Goda Y, Xu W, Noguchi H, Yamamoto T, Hotta K, Houk KN, Tang Y, Watanabe K. Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition. Chembiochem : a European Journal of Chemical Biology. PMID 26360642 DOI: 10.1002/cbic.201500386  1
2015 Mao XM, Zhan ZJ, Grayson MN, Tang MC, Xu W, Li YQ, Yin WB, Lin HC, Chooi YH, Houk KN, Tang Y. Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System. Journal of the American Chemical Society. PMID 26340065 DOI: 10.1021/jacs.5b07816  1
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/nchembio.1890  1
2015 Tan KC, Phan HT, Rybak K, John E, Chooi YH, Solomon PS, Oliver RP. Functional redundancy of necrotrophic effectors - consequences for exploitation for breeding. Frontiers in Plant Science. 6: 501. PMID 26217355 DOI: 10.3389/fpls.2015.00501  1
2015 Mao XM, Xu W, Li D, Yin WB, Chooi YH, Li YQ, Tang Y, Hu Y. Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products. Angewandte Chemie (International Ed. in English). 54: 7592-6. PMID 26013262 DOI: 10.1002/anie.201502452  1
2015 Lin HC, Chiou G, Chooi YH, McMahon TC, Xu W, Garg NK, Tang Y. Elucidation of the concise biosynthetic pathway of the communesin indole alkaloids. Angewandte Chemie (International Ed. in English). 54: 3004-7. PMID 25571861 DOI: 10.1002/anie.201411297  1
2015 Chooi YH, Krill C, Barrow RA, Chen S, Trengove R, Oliver RP, Solomon PS. An in planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum. Applied and Environmental Microbiology. 81: 177-86. PMID 25326302 DOI: 10.1128/AEM.02745-14  1
2014 Cacho RA, Tang Y, Chooi YH. Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi. Frontiers in Microbiology. 5: 774. PMID 25642215 DOI: 10.3389/fmicb.2014.00774  1
2014 Zabala AO, Chooi YH, Choi MS, Lin HC, Tang Y. Fungal polyketide synthase product chain-length control by partnering thiohydrolase. Acs Chemical Biology. 9: 1576-86. PMID 24845309 DOI: 10.1021/cb500284t  1
2014 Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y. Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway. Journal of the American Chemical Society. 136: 4426-36. PMID 24568283 DOI: 10.1021/ja500881e  1
2013 Chooi YH, Hong YJ, Cacho RA, Tantillo DJ, Tang Y. A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis. Journal of the American Chemical Society. 135: 16805-8. PMID 24161266 DOI: 10.1021/ja408966t  1
2013 Cacho RA, Chooi YH, Zhou H, Tang Y. Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin. Acs Chemical Biology. 8: 2322-30. PMID 23978092 DOI: 10.1021/cb400541z  1
2013 Yin WB, Chooi YH, Smith AR, Cacho RA, Hu Y, White TC, Tang Y. Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. Acs Synthetic Biology. 2: 629-34. PMID 23758576 DOI: 10.1021/sb400048b  1
2013 Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y. LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angewandte Chemie (International Ed. in English). 52: 6472-5. PMID 23653178 DOI: 10.1002/anie.201302406  1
2013 Lin HC, Chooi YH, Dhingra S, Xu W, Calvo AM, Tang Y. The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. Journal of the American Chemical Society. 135: 4616-9. PMID 23488861 DOI: 10.1021/ja312503y  1
2013 Chooi YH, Fang J, Liu H, Filler SG, Wang P, Tang Y. Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Organic Letters. 15: 780-3. PMID 23368997 DOI: 10.1021/ol303435y  1
2012 Cacho RA, Jiang W, Chooi YH, Walsh CT, Tang Y. Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. Journal of the American Chemical Society. 134: 16781-90. PMID 22998630 DOI: 10.1021/ja307220z  1
2012 Chooi YH, Tang Y. Navigating the fungal polyketide chemical space: from genes to molecules. The Journal of Organic Chemistry. 77: 9933-53. PMID 22938194 DOI: 10.1021/jo301592k  1
2012 Zabala AO, Xu W, Chooi YH, Tang Y. Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chemistry & Biology. 19: 1049-59. PMID 22921072 DOI: 10.1016/j.chembiol.2012.07.004  1
2012 Wackler B, Lackner G, Chooi YH, Hoffmeister D. Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α-keto acids. Chembiochem : a European Journal of Chemical Biology. 13: 1798-804. PMID 22730234 DOI: 10.1002/cbic.201200187  1
2012 Chooi YH, Wang P, Fang J, Li Y, Wu K, Wang P, Tang Y. Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases. Journal of the American Chemical Society. 134: 9428-37. PMID 22590971 DOI: 10.1021/ja3028636  1
2012 Liu Q, Yao F, Chooi YH, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D. Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation. Chemistry & Biology. 19: 243-53. PMID 22365607 DOI: 10.1016/j.chembiol.2011.12.018  1
2011 Pickens LB, Tang Y, Chooi YH. Metabolic engineering for the production of natural products. Annual Review of Chemical and Biomolecular Engineering. 2: 211-36. PMID 22432617 DOI: 10.1146/annurev-chembioeng-061010-114209  1
2011 Qiao K, Chooi YH, Tang Y. Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. Metabolic Engineering. 13: 723-32. PMID 21983160 DOI: 10.1016/j.ymben.2011.09.008  1
2011 Li Y, Chooi YH, Sheng Y, Valentine JS, Tang Y. Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. Journal of the American Chemical Society. 133: 15773-85. PMID 21866960 DOI: 10.1021/ja206906d  1
2011 Wang P, Gao X, Chooi YH, Deng Z, Tang Y. Genetic characterization of enzymes involved in the priming steps of oxytetracycline biosynthesis in Streptomyces rimosus. Microbiology (Reading, England). 157: 2401-9. PMID 21622525 DOI: 10.1099/mic.0.048439-0  1
2011 Gao X, Chooi YH, Ames BD, Wang P, Walsh CT, Tang Y. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Journal of the American Chemical Society. 133: 2729-41. PMID 21299212 DOI: 10.1021/ja1101085  1
2010 Chooi YH, Tang Y. Adding the lipo to lipopeptides: do more with less. Chemistry & Biology. 17: 791-3. PMID 20797606 DOI: 10.1016/j.chembiol.2010.08.001  1
2010 Chooi YH, Cacho R, Tang Y. Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chemistry & Biology. 17: 483-94. PMID 20534346 DOI: 10.1016/j.chembiol.2010.03.015  1
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