| Year |
Citation |
Score |
| 2025 |
Godinez-Macias KP, Chen D, Wallis JL, Siegel MG, Adam A, Bopp S, Carolino K, Coulson LB, Durst G, Thathy V, Esherick L, Farringer MA, Flannery EL, Forte B, Liu T, ... ... Lukens AK, et al. Revisiting the druggable genome using predicted structures and data mining. Npj Drug Discovery. 2: 3. PMID 40066064 DOI: 10.1038/s44386-025-00006-5 |
0.546 |
|
| 2024 |
Godinez-Macias KP, Chen D, Wallis JL, Siegel MG, Adam A, Bopp S, Carolino K, Coulson LB, Durst G, Thathy V, Esherick L, Farringer MA, Flannery EL, Forte B, Liu T, ... ... Lukens AK, et al. Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining. Research Square. PMID 39649165 DOI: 10.21203/rs.3.rs-5412515/v1 |
0.583 |
|
| 2024 |
Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, ... ... Lukens AK, et al. Systematic in vitro evolution in reveals key determinants of drug resistance. Science (New York, N.Y.). 386: eadk9893. PMID 39607932 DOI: 10.1126/science.adk9893 |
0.635 |
|
| 2023 |
Mandt REK, Luth MR, Tye MA, Mazitschek R, Ottilie S, Winzeler EA, Lafuente-Monasterio MJ, Gamo FJ, Wirth DF, Lukens AK. Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance. Elife. 12. PMID 37737220 DOI: 10.7554/eLife.85023 |
0.647 |
|
| 2023 |
Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, ... ... Lukens AK, et al. Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature Communications. 14: 1455. PMID 36927839 DOI: 10.1038/s41467-023-36921-2 |
0.646 |
|
| 2022 |
Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, et al. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nature Communications. 13: 4976. PMID 36008486 DOI: 10.1038/s41467-022-32630-4 |
0.596 |
|
| 2022 |
Ottilie S, Luth MR, Hellemann E, Goldgof GM, Vigil E, Kumar P, Cheung AL, Song M, Godinez-Macias KP, Carolino K, Yang J, Lopez G, Abraham M, Tarsio M, LeBlanc E, ... ... Lukens AK, et al. Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Communications Biology. 5: 128. PMID 35149760 DOI: 10.1038/s42003-022-03076-7 |
0.563 |
|
| 2021 |
Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK, McNamara CW, Niles JC, Okombo J, Pasaje CFA, Siegel MG, et al. Prioritization of Molecular Targets for Antimalarial Drug Discovery. Acs Infectious Diseases. PMID 34523908 DOI: 10.1021/acsinfecdis.1c00322 |
0.531 |
|
| 2021 |
Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, ... ... Lukens AK, et al. Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chemical Biology. PMID 34348113 DOI: 10.1016/j.chembiol.2021.07.010 |
0.622 |
|
| 2021 |
Murithi JM, Deni I, Pasaje CFA, Okombo J, Bridgford JL, Gnädig NF, Edwards RL, Yeo T, Mok S, Burkhard AY, Coburn-Flynn O, Istvan ES, Sakata-Kato T, Gomez-Lorenzo MG, Cowell AN, ... ... Lukens AK, et al. The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chemical Biology. PMID 34233174 DOI: 10.1016/j.chembiol.2021.06.006 |
0.64 |
|
| 2021 |
Yang T, Ottilie S, Istvan ES, Godinez-Macias KP, Lukens AK, Baragaña B, Campo B, Walpole C, Niles JC, Chibale K, Dechering KJ, Llinás M, Lee MCS, Kato N, Wyllie S, et al. MalDA, Accelerating Malaria Drug Discovery. Trends in Parasitology. PMID 33648890 DOI: 10.1016/j.pt.2021.01.009 |
0.566 |
|
| 2020 |
McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, et al. Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports. 10: 5512. PMID 32251362 DOI: 10.1038/S41598-020-62323-1 |
0.469 |
|
| 2019 |
Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science Translational Medicine. 11. PMID 31801884 DOI: 10.1126/Scitranslmed.Aav1636 |
0.683 |
|
| 2019 |
Fagbami L, Deik AA, Herman JD, Singh K, Santos SA, Bopp S, Lukens AK, Clish CB, Wirth DF, Mazitschek R. The adaptive proline response in P. falciparum is independent of PfeIK1 and eIF2α signaling. Acs Infectious Diseases. PMID 30773881 DOI: 10.1021/Acsinfecdis.8B00363 |
0.627 |
|
| 2018 |
Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado Rodriguez JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, et al. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science (New York, N.Y.). 362. PMID 30523084 DOI: 10.1126/Science.Aat9446 |
0.619 |
|
| 2018 |
Ross LS, Lafuente-Monasterio MJ, Sakata-Kato T, Mandt REK, Gamo FJ, Wirth DF, Lukens AK. Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum. Acs Infectious Diseases. PMID 29336544 DOI: 10.1021/Acsinfecdis.7B00217 |
0.756 |
|
| 2018 |
Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, et al. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science (New York, N.Y.). 359: 191-199. PMID 29326268 DOI: 10.1126/Science.Aan4472 |
0.694 |
|
| 2017 |
Wirth DF, Winzeler EA, Fenton B, Adams JH, Ariey F, Barillas-Mury CV, Baum J, Bhatia SN, Billker O, Bopp SE, Catteruccia F, Cowman AF, Chitnis CE, Crabb BS, Deitsch KW, ... ... Lukens AK, et al. malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication Plos Medicine. 14. PMID 29190277 DOI: 10.1371/Journal.Pmed.1002451 |
0.512 |
|
| 2017 |
Nilsson Bark SK, Ahmad R, Dantzler K, Lukens AK, De Niz M, Szucs MJ, Jin X, Cotton J, Hoffmann D, Bric-Furlong E, Oomen R, Parrington M, Milner D, Neafsey DE, Carr SA, et al. Quantitative proteomic profiling reveals novel Plasmodium falciparum surface antigens and possible vaccine candidates. Molecular & Cellular Proteomics : McP. PMID 29162636 DOI: 10.1074/Mcp.Ra117.000076 |
0.594 |
|
| 2016 |
Volkman SK, Herman J, Lukens AK, Hartl DL. Genome-Wide Association Studies of Drug-Resistance Determinants. Trends in Parasitology. PMID 28179098 DOI: 10.1016/J.Pt.2016.10.001 |
0.506 |
|
| 2016 |
Vunnam S, Reddy A, Mazitschek R, Lukens AK, Wirth DF, Li L, Naumov P, O'Connor MJ, Al-Tel TH. Intramolecular Diaza-Diels-Alder Protocol: A Novel Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27997727 DOI: 10.1002/Chem.201605231 |
0.603 |
|
| 2016 |
Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M, Winzeler E, Wirth DF. Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. Acs Infectious Diseases. 2: 816-826. PMID 27933786 DOI: 10.1021/Acsinfecdis.6B00025 |
0.657 |
|
| 2016 |
Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Lukens AK, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/Nature19804 |
0.614 |
|
| 2016 |
Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, J V A Dos Santos D, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. Chemmedchem. PMID 27538856 DOI: 10.1002/Cmdc.201600327 |
0.624 |
|
| 2016 |
McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, et al. New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports. 6: 29179. PMID 27412848 DOI: 10.1038/Srep29179 |
0.595 |
|
| 2016 |
Corey VC, Lukens AK, Istvan ES, Lee MC, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, et al. A broad analysis of resistance development in the malaria parasite. Nature Communications. 7: 11901. PMID 27301419 DOI: 10.1038/Ncomms11901 |
0.664 |
|
| 2015 |
Santos SA, Lukens AK, Coelho L, Nogueira F, Wirth DF, Mazitschek R, Moreira R, Paulo A. Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. European Journal of Medicinal Chemistry. 102: 320-33. PMID 26295174 DOI: 10.1016/J.Ejmech.2015.07.047 |
0.644 |
|
| 2015 |
Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Science Translational Medicine. 7: 288ra77. PMID 25995223 DOI: 10.1126/Scitranslmed.Aaa3575 |
0.691 |
|
| 2015 |
Hameed P S, Solapure S, Patil V, Henrich PP, Magistrado PA, Bharath S, Murugan K, Viswanath P, Puttur J, Srivastava A, Bellale E, Panduga V, Shanbag G, Awasthy D, Landge S, ... ... Lukens AK, et al. Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate. Nature Communications. 6: 6715. PMID 25823686 DOI: 10.1038/Ncomms7715 |
0.626 |
|
| 2015 |
Lukens AK, Heidebrecht RW, Mulrooney C, Beaudoin JA, Comer E, Duvall JR, Fitzgerald ME, Masi D, Galinsky K, Scherer CA, Palmer M, Munoz B, Foley M, Schreiber SL, Wiegand RC, et al. Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors. The Journal of Infectious Diseases. 211: 1097-103. PMID 25336726 DOI: 10.1093/Infdis/Jiu565 |
0.617 |
|
| 2015 |
Volkman S, Daniels R, Chang H, Park D, Neafsey D, Schaffner S, Lukens A, Mboup S, Sabeti P, Wirth D, Hartl D. Genotyping malaria parasites to understand malaria transmission Annals of Global Health. 81: 82. DOI: 10.1016/J.Aogh.2015.02.694 |
0.736 |
|
| 2014 |
Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, et al. Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents. Journal of Medicinal Chemistry. 57: 8496-502. PMID 25211597 DOI: 10.1021/Jm500994N |
0.56 |
|
| 2014 |
Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, ... ... Lukens AK, et al. Aminoazabenzimidazoles, a novel class of orally active antimalarial agents. Journal of Medicinal Chemistry. 57: 5702-13. PMID 24914738 DOI: 10.1021/Jm500535J |
0.626 |
|
| 2014 |
Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF. Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proceedings of the National Academy of Sciences of the United States of America. 111: 799-804. PMID 24381157 DOI: 10.1073/Pnas.1320886110 |
0.766 |
|
| 2013 |
Ndiaye D, Dieye B, Ndiaye YD, Van Tyne D, Daniels R, Bei AK, Mbaye A, Valim C, Lukens A, Mboup S, Ndir O, Wirth DF, Volkman S. Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal. International Journal For Parasitology. Drugs and Drug Resistance. 3: 135-42. PMID 24533303 DOI: 10.1016/J.Ijpddr.2013.07.001 |
0.791 |
|
| 2013 |
Van Tyne D, Dieye B, Valim C, Daniels RF, Sène PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D. Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malaria Journal. 12: 441. PMID 24314037 DOI: 10.1186/1475-2875-12-441 |
0.798 |
|
| 2013 |
Daniels R, Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D, Mboup S, Sabeti PC, Ndiaye D, Wirth DF, Hartl DL, Volkman SK. Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. Plos One. 8: e60780. PMID 23593309 DOI: 10.1371/Journal.Pone.0060780 |
0.778 |
|
| 2012 |
Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, et al. Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proceedings of the National Academy of Sciences of the United States of America. 109: 13052-7. PMID 22826220 DOI: 10.1073/Pnas.1210585109 |
0.773 |
|
| 2012 |
Amambua-Ngwa A, Park DJ, Volkman SK, Barnes KG, Bei AK, Lukens AK, Sene P, Van Tyne D, Ndiaye D, Wirth DF, Conway DJ, Neafsey DE, Schaffner SF. SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites. Molecular Biology and Evolution. 29: 3249-53. PMID 22688945 DOI: 10.1093/Molbev/Mss151 |
0.755 |
|
| 2012 |
Heidebrecht RW, Mulrooney C, Austin CP, Barker RH, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, ... ... Lukens AK, et al. Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. Acs Medicinal Chemistry Letters. 3: 112-117. PMID 22328964 DOI: 10.1021/Ml200244K |
0.607 |
|
| 2012 |
Milner DA, Vareta J, Valim C, Montgomery J, Daniels RF, Volkman SK, Neafsey DE, Park DJ, Schaffner SF, Mahesh NC, Barnes KG, Rosen DM, Lukens AK, Van Tyne D, Wiegand RC, et al. Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. Malaria Journal. 11: 35. PMID 22314206 DOI: 10.1186/1475-2875-11-35 |
0.765 |
|
| 2011 |
Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, et al. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. Plos Genetics. 7: e1001383. PMID 21533027 DOI: 10.1371/Journal.Pgen.1001383 |
0.803 |
|
| 2008 |
Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, et al. Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biology. 9: R171. PMID 19077304 DOI: 10.1186/Gb-2008-9-12-R171 |
0.703 |
|
| 2007 |
Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, et al. A genome-wide map of diversity in Plasmodium falciparum. Nature Genetics. 39: 113-9. PMID 17159979 DOI: 10.1038/Ng1930 |
0.68 |
|
| 2005 |
Daily JP, Le Roch KG, Sarr O, Ndiaye D, Lukens A, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. The Journal of Infectious Diseases. 191: 1196-203. PMID 15747257 DOI: 10.1086/428289 |
0.608 |
|
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