Neil L. Kelleher, Ph.D. - Publications

Molecular Biosciences, Chemistry Department, and Feinberg School of Medicine Northwestern University, Evanston, IL 

308 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lue JK, Prabhu SA, Liu Y, Gonzalez Y, Verma A, Mundi PS, Abshiru NA, Camarillo JM, Mehta S, Chen EI, Qiao C, Nandakumar R, Cremers S, Kelleher NL, Elemento O, et al. Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30979734 DOI: 10.1158/1078-0432.CCR-18-3989  0.48
2019 Schachner LF, Ives AN, McGee JP, Melani RD, Kafader JO, Compton PD, Patrie SM, Kelleher NL. Standard Proteoforms and Their Complexes for Native Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 30963455 DOI: 10.1007/s13361-019-02191-w  1
2019 LeDuc RD, Fellers RT, Early BP, Greer JB, Shams DP, Thomas P, Kelleher NL. Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics. Molecular & Cellular Proteomics : McP. PMID 30647073 DOI: 10.1074/mcp.RA118.000993  1
2019 Kafader JO, Melani RD, Senko MW, Makarov AA, Kelleher NL, Compton PD. Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins. Analytical Chemistry. PMID 30609364 DOI: 10.1021/acs.analchem.8b04519  0.88
2018 Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Lo Bu R, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, ... ... Kelleher NL, et al. A Novel Crosslinking Protocol Stabilizes Amyloid β Oligomers Capable of Inducing Alzheimer's-Associated Pathologies. Journal of Neurochemistry. PMID 30565253 DOI: 10.1111/jnc.14647  0.88
2018 Toby TK, Fornelli L, Srzentić K, DeHart CJ, Levitsky J, Friedewald J, Kelleher NL. A comprehensive pipeline for translational top-down proteomics from a single blood draw. Nature Protocols. PMID 30518910 DOI: 10.1038/s41596-018-0085-7  0.72
2018 Fisher OS, Kenney GE, Ross MO, Ro SY, Lemma BE, Batelu S, Thomas PM, Sosnowski VC, DeHart CJ, Kelleher NL, Stemmler TL, Hoffman BM, Rosenzweig AC. Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria. Nature Communications. 9: 4276. PMID 30323281 DOI: 10.1038/s41467-018-06681-5  0.96
2018 Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutiérrez-Díaz BT, Wang KK, Johnson MR, Volk A, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, ... ... Kelleher NL, et al. USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30224337 DOI: 10.1158/1078-0432.CCR-18-1740  0.96
2018 Gruppuso PA, Boylan JM, Zabala V, Neretti N, Abshiru NA, Sikora JW, Doud EH, Camarillo JM, Thomas PM, Kelleher NL, Sanders JA. Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells. Plos One. 13: e0203351. PMID 30192817 DOI: 10.1371/journal.pone.0203351  0.96
2018 Swaroop A, Oyer JA, Will CM, Huang X, Yu W, Troche C, Bulic M, Durham BH, Wen QJ, Crispino JD, MacKerell AD, Bennett RL, Kelleher NL, Licht JD. An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia. Oncogene. PMID 30171259 DOI: 10.1038/s41388-018-0474-y  0.4
2018 Compton PD, Kelleher NL, Gunawardena J. Estimating the distribution of protein post-translational modification states by mass-spectrometry. Journal of Proteome Research. PMID 29945451 DOI: 10.1021/acs.jproteome.8b00150  0.88
2018 Riley NM, Sikora JW, Seckler HS, Greer JB, Fellers RT, LeDuc RD, Westphall MS, Thomas PM, Kelleher NL, Coon JJ. The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins. Analytical Chemistry. PMID 29924586 DOI: 10.1021/acs.analchem.8b01638  1
2018 Mullowney MW, McClure RA, Robey MT, Kelleher NL, Thomson RJ. Natural products from thioester reductase containing biosynthetic pathways. Natural Product Reports. PMID 29916519 DOI: 10.1039/c8np00013a  0.96
2018 Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL. Accurate sequence analysis of a monoclonal antibody by top-down and middle-down Orbitrap mass spectrometry applying multiple ion activation techniques. Analytical Chemistry. PMID 29894161 DOI: 10.1021/acs.analchem.8b00984  0.88
2018 Alvares K, DeHart CJ, Thomas PM, Kelleher NL, Veis A. The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth. Connective Tissue Research. 59: 20-29. PMID 29745816 DOI: 10.1080/03008207.2017.1408605  0.96
2018 Park YJ, Kenney GE, Schachner LF, Kelleher NL, Rosenzweig AC. Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins. Biochemistry. PMID 29694778 DOI: 10.1021/acs.biochem.8b00296  0.6
2018 Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D. β-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site. Journal of the American Chemical Society. PMID 29676907 DOI: 10.1021/jacs.7b13003  1
2018 Dos Santos Seckler H, Fornelli L, Mutharasan RK, Thaxton CS, Fellers RT, Daviglus M, Sniderman A, Rader D, Kelleher NL, Lloyd-Jones DM, Compton PD, Wilkins JT. A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity. Journal of Proteome Research. PMID 29649363 DOI: 10.1021/acs.jproteome.8b00100  0.88
2018 Robey MT, Ye R, Bok JW, Clevenger KD, Islam MN, Chen C, Gupta R, Swyers M, Wu E, Gao P, Thomas PM, Wu CC, Keller NP, Kelleher NL. Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology. Acs Chemical Biology. PMID 29631395 DOI: 10.1021/acschembio.8b00024  0.96
2018 Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL. Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610327 DOI: 10.1073/pnas.1716122115  1
2018 Miley GP, Rote JC, Silverman RB, Kelleher NL, Thomson RJ. Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization. Organic Letters. PMID 29584440 DOI: 10.1021/acs.orglett.8b00700  0.96
2018 Martin RW, Des Soye BJ, Kwon YC, Kay J, Davis RG, Thomas PM, Majewska NI, Chen CX, Marcum RD, Weiss MG, Stoddart AE, Amiram M, Ranji Charna AK, Patel JR, Isaacs FJ, ... Kelleher NL, et al. Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids. Nature Communications. 9: 1203. PMID 29572528 DOI: 10.1038/s41467-018-03469-5  0.96
2018 Kenney GE, Dassama LMK, Pandelia ME, Gizzi AS, Martinie RJ, Gao P, DeHart CJ, Schachner LF, Skinner OS, Ro SY, Zhu X, Sadek M, Thomas PM, Almo SC, Bollinger JM, ... ... Kelleher NL, et al. The biosynthesis of methanobactin. Science (New York, N.Y.). 359: 1411-1416. PMID 29567715 DOI: 10.1126/science.aap9437  1
2018 Clevenger KD, Ye R, Bok JW, Thomas PM, Islam MN, Miley GP, Robey M, Chen C, Yang K, Swyers M, Wu E, Gao P, Wu C, Keller NP, Kelleher NL. Interrogation of Benzomalvin Biosynthesis using FAC-MS: Discovery of a Benzodiazepine Synthase Activity. Biochemistry. PMID 29533658 DOI: 10.1021/acs.biochem.8b00076  0.96
2018 Parkinson EI, Tryon JH, Goering AW, Ju KS, McClure RA, Kemball JD, Zhukovsky S, Labeda DP, Thomson RJ, Kelleher NL, Metcalf WW. Discovery of the tyrobetaine natural products and their biosynthetic gene cluster via metabologenomics. Acs Chemical Biology. PMID 29510029 DOI: 10.1021/acschembio.7b01089  0.96
2018 Davis RG, Park HM, Kim K, Greer JB, Fellers RT, LeDuc RD, Romanova EV, Rubakhin SS, Zombeck JA, Wu C, Yau PM, Gao P, van Nispen AJ, Patrie SM, Thomas PM, ... ... Kelleher NL, et al. Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains. Analytical Chemistry. PMID 29481055 DOI: 10.1021/acs.analchem.7b04108  1
2018 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, ... ... Kelleher NL, et al. How many human proteoforms are there? Nature Chemical Biology. 14: 206-214. PMID 29443976 DOI: 10.1038/nchembio.2576  1
2018 LeDuc RD, Schwämmle V, Shortreed MR, Cesnik AJ, Solntsev SK, Shaw JB, Martin MJ, Vizcaíno JA, Alpi E, Danis P, Kelleher NL, Smith LM, Ge Y, Agar JN, Chamot-Rooke J, et al. ProForma: a Standard Proteoform Notation. Journal of Proteome Research. PMID 29397739 DOI: 10.1021/acs.jproteome.7b00851  1
2017 Harris D, Lukoyanov D, Shaw S, Compton PD, Tokmina-Lukaszewska M, Bothner B, Kelleher NL, Dean DR, Hoffman BM, Seefeldt LC. The Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2. Biochemistry. PMID 29283553 DOI: 10.1021/acs.biochem.7b01142  0.88
2017 Turcan S, Makarov V, Taranda J, Wang Y, Fabius AWM, Wu W, Zheng Y, El-Amine N, Haddock S, Nanjangud G, LeKaye HC, Brennan C, Cross J, Huse JT, Kelleher NL, et al. Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence. Nature Genetics. PMID 29180699 DOI: 10.1038/s41588-017-0001-z  0.92
2017 Skinner OS, Haverland NA, Fornelli L, Melani RD, Do Vale LHF, Seckler HS, Doubleday PF, Schachner LF, Srzentić K, Kelleher NL, Compton PD. Top-down characterization of endogenous protein complexes with native proteomics. Nature Chemical Biology. PMID 29131144 DOI: 10.1038/nchembio.2515  1
2017 Morgan MAJ, Rickels RA, Collings CK, He X, Cao K, Herz HM, Cozzolino KA, Abshiru NA, Marshall SA, Rendleman EJ, Sze CC, Piunti A, Kelleher NL, Savas JN, Shilatifard A. A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Genes & Development. 31: 2003-2014. PMID 29089422 DOI: 10.1101/gad.305201.117  0.44
2017 Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D. Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. PMID 29045130 DOI: 10.1021/acs.biochem.7b00961  0.52
2017 Rickels R, Herz HM, Sze CC, Cao K, Morgan MA, Collings CK, Gause M, Takahashi YH, Wang L, Rendleman EJ, Marshall SA, Krueger A, Bartom ET, Piunti A, Smith ER, ... ... Kelleher NL, et al. Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability. Nature Genetics. PMID 28967912 DOI: 10.1038/ng.3965  0.56
2017 Skinner OS, McAnally MO, Van Duyne RP, Schatz GC, Breuker K, Compton PD, Kelleher NL. Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin. Analytical Chemistry. PMID 28938074 DOI: 10.1021/acs.analchem.7b01581  1
2017 Ichikawa Y, Connelly CF, Appleboim A, Miller TC, Jacobi H, Abshiru NA, Chou HJ, Chen Y, Sharma U, Zheng Y, Thomas PM, Chen HV, Bajaj V, Müeller CW, Kelleher NL, et al. A synthetic biology approach to probing nucleosome symmetry. Elife. 6. PMID 28895528 DOI: 10.7554/eLife.28836  0.96
2017 Wildburger NC, Esparza TJ, LeDuc RD, Fellers RT, Thomas PM, Cairns NJ, Kelleher NL, Bateman RJ, Brody DL. Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain. Scientific Reports. 7: 9520. PMID 28842697 DOI: 10.1038/s41598-017-10422-x  1
2017 Haverland NA, Waas M, Ntai I, Keppel T, Gundry RL, Kelleher NL. Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes. Proteomics. PMID 28834292 DOI: 10.1002/pmic.201700156  1
2017 Mascarenhas R, Le HV, Clevenger KD, Lehrer HJ, Ringe D, Kelleher NL, Silverman RB, Liu D. Selective Targeting by a Mechanism-based Inactivator against PLP-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. PMID 28816437 DOI: 10.1021/acs.biochem.7b00499  0.52
2017 Zha L, Jiang Y, Henke MT, Wilson MR, Wang JX, Kelleher NL, Balskus EP. Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring. Nature Chemical Biology. PMID 28805802 DOI: 10.1038/nchembio.2448  1
2017 Clevenger KD, Bok JW, Ye R, Miley GP, Verdan MH, Velk T, Chen C, Yang K, Robey MT, Gao P, Lamprecht M, Thomas PM, Islam MN, Palmer JM, Wu CC, ... ... Kelleher NL, et al. A scalable platform to identify fungal secondary metabolites and their gene clusters. Nature Chemical Biology. PMID 28604695 DOI: 10.1038/nchembio.2408  0.96
2017 Cleland TP, DeHart CJ, Fellers RT, VanNispen AJ, Greer JB, LeDuc RD, Parker WR, Thomas PM, Kelleher NL, Brodbelt JS. High-throughput analysis of intact human proteins using UVPD and HCD on an Orbitrap mass spectrometer. Journal of Proteome Research. PMID 28412815 DOI: 10.1021/acs.jproteome.7b00043  1
2017 Greer SM, Holden DD, Fellers R, Kelleher NL, Brodbelt JS. Modulation of Protein Fragmentation Through Carbamylation of Primary Amines. Journal of the American Society For Mass Spectrometry. PMID 28374316 DOI: 10.1007/s13361-017-1648-5  0.56
2017 Haverland NA, Skinner OS, Fellers RT, Tariq AA, Early BP, LeDuc RD, Fornelli L, Compton PD, Kelleher NL. Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 28374312 DOI: 10.1007/s13361-017-1635-x  1
2017 Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM, Kelleher NL, et al. Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Nature Medicine. PMID 28263307 DOI: 10.1038/nm.4296  0.44
2017 Mandacaru SC, Vale LH, Vahidi S, Xiao Y, Skinner OS, Ricart CA, Kelleher NL, Sousa MV, Konermann L. Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools. Biochemistry. PMID 28252287 DOI: 10.1021/acs.biochem.7b00020  1
2017 Fornelli L, Toby TK, Schachner LF, Doubleday PF, Srzentić K, DeHart CJ, Kelleher NL. Top-down proteomics: Where we are, where we are going? Journal of Proteomics. PMID 28188863 DOI: 10.1016/j.jprot.2017.02.002  0.72
2017 Clevenger KD, Mascarenhas R, Catlin D, Wu R, Kelleher NL, Drake EJ, Gulick AM, Liu D, Fast W. Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ. Acs Chemical Biology. PMID 28186406 DOI: 10.1021/acschembio.7b00031  0.4
2017 Fornelli L, Durbin KR, Fellers RT, Early BP, Greer JB, LeDuc RD, Compton PD, Kelleher NL. Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer. Journal of Proteome Research. 16: 609-618. PMID 28152595 DOI: 10.1021/acs.jproteome.6b00698  1
2017 DeHart CJ, Fellers RT, Fornelli L, Kelleher NL, Thomas PM. Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite. Methods in Molecular Biology (Clifton, N.J.). 1558: 381-394. PMID 28150248 DOI: 10.1007/978-1-4939-6783-4_18  0.96
2017 Schroeter ER, DeHart CJ, Cleland TP, Zheng W, Thomas PM, Kelleher NL, Bern M, Schweitzer MH. Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein. Journal of Proteome Research. PMID 28111950 DOI: 10.1021/acs.jproteome.6b00873  0.96
2016 Gan R, Perez JG, Carlson ED, Ntai I, Isaacs FJ, Kelleher NL, Jewett MC. Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins. Biotechnology and Bioengineering. PMID 27987323 DOI: 10.1002/bit.26239  1
2016 Anderson LC, DeHart CJ, Kaiser NK, Fellers RT, Smith DF, Greer JB, LeDuc RD, Blakney GT, Thomas PM, Kelleher NL, Hendrickson CL. Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry. Journal of Proteome Research. PMID 27936753 DOI: 10.1021/acs.jproteome.6b00696  1
2016 Skinner OS, Schachner LF, Kelleher NL. The Search Engine for Multi-Proteoform Complexes: An Online Tool for the Identification and Stoichiometry Determination of Protein Complexes. Current Protocols in Bioinformatics. 56: 13.30.1-13.30.11. PMID 27930806 DOI: 10.1002/cpbi.16  1
2016 Schroeter ER, DeHart CJ, Schweitzer MH, Thomas PM, Kelleher NL. Bone protein "extractomics": comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics. Peerj. 4: e2603. PMID 27812413 DOI: 10.7717/peerj.2603  0.96
2016 McClure RA, Goering AW, Ju KS, Baccile JA, Schroeder FC, Metcalf WW, Thomson RJ, Kelleher NL. Elucidating the rimosamide-detoxin natural product families and their biosynthesis using metabolite/gene cluster correlations. Acs Chemical Biology. PMID 27809474 DOI: 10.1021/acschembio.6b00779  0.96
2016 Savaryn JP, Toby TK, Kelleher NL. A researcher's guide to mass spectrometry-based proteomics. Proteomics. PMID 27553853 DOI: 10.1002/pmic.201600113  0.72
2016 Kenney GE, Goering AW, Ross MO, DeHart CJ, Thomas PM, Hoffman BM, Kelleher NL, Rosenzweig AC. Characterization of methanobactin from Methylosinus sp. LW4. Journal of the American Chemical Society. PMID 27527063 DOI: 10.1021/jacs.6b06821  0.36
2016 Goering AW, Li J, McClure RA, Thomson RJ, Jewett MC, Kelleher NL. In vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis. Acs Synthetic Biology. PMID 27478992 DOI: 10.1021/acssynbio.6b00160  0.96
2016 Moussazadeh N, Berman SH, Laufer I, Gounder M, Zheng Y, Sommer J, Bilsky MH, Kelleher NL, Brennan C. 365 Epigenetic Profiling Reveals a Unique Histone Code in Chordoma. Neurosurgery. 63: 208. PMID 27399562 DOI: 10.1227/01.neu.0000489853.78064.b2  0.92
2016 Henke MT, Kelleher NL. Modern mass spectrometry for synthetic biology and structure-based discovery of natural products. Natural Product Reports. PMID 27376415 DOI: 10.1039/c6np00024j  1
2016 Zheng Y, Huang X, Kelleher NL. Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry. Current Opinion in Chemical Biology. 33: 142-150. PMID 27371874 DOI: 10.1016/j.cbpa.2016.06.007  0.92
2016 Henke MT, Soukup AA, Goering AW, McClure RA, Thomson RJ, Keller NP, Kelleher NL. New aspercryptins, lipopeptide natural products, revealed by HDAC inhibition in Aspergillus nidulans. Acs Chemical Biology. PMID 27310134 DOI: 10.1021/acschembio.6b00398  1
2016 Toby TK, Fornelli L, Kelleher NL. Progress in Top-Down Proteomics and the Analysis of Proteoforms. Annual Review of Analytical Chemistry (Palo Alto, Calif.). 9: 499-519. PMID 27306313 DOI: 10.1146/annurev-anchem-071015-041550  0.72
2016 LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, ... ... Kelleher NL, et al. Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status". Nature Medicine. 22: 578-579. PMID 27270773 DOI: 10.1038/nm.4094  0.96
2016 Melani RD, Skinner OS, Fornelli L, Domont GB, Compton PD, Kelleher NL. Mapping proteoforms and protein complexes from king cobra venom using both denaturing and native top-down proteomics. Molecular & Cellular Proteomics : McP. PMID 27178327 DOI: 10.1074/mcp.M115.056523  1
2016 Goering AW, McClure RA, Doroghazi JR, Albright JC, Haverland NA, Zhang Y, Ju KS, Thomson RJ, Metcalf WW, Kelleher NL. Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. Acs Central Science. 2: 99-108. PMID 27163034 DOI: 10.1021/acscentsci.5b00331  0.96
2016 Savaryn JP, Toby TK, Catherman AD, Fellers RT, LeDuc RD, Thomas PM, Friedewald JJ, Salomon DR, Abecassis MM, Kelleher NL. Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection. Proteomics. PMID 27120713 DOI: 10.1002/pmic.201600008  1
2016 Melani RD, Seckler HS, Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, Valle de Sousa M, Domont GB, Kelleher NL, Compton PD. CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis. Journal of Visualized Experiments : Jove. PMID 26967310 DOI: 10.3791/53597  0.4
2016 Gunn BM, Schneider JR, Shansab M, Bastian AR, Fahrbach KM, Smith AD, Mahan AE, Karim MM, Licht AF, Zvonar I, Tedesco J, Anderson MR, Chapel A, Suscovich TJ, Malaspina DC, ... ... Kelleher NL, et al. Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16. Mucosal Immunology. PMID 26960182 DOI: 10.1038/mi.2016.8  0.36
2016 Ong TH, Romanova EV, Roberts-Galbraith RH, Yang N, Zimmerman TA, Collins JJ, Lee JE, Kelleher NL, Newmark PA, Sweedler JV. Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea. The Journal of Biological Chemistry. 291: 8109-20. PMID 26884331 DOI: 10.1074/jbc.M115.709196  0.88
2016 Ntai I, Toby TK, LeDuc RD, Kelleher NL. A Method for Label-Free, Differential Top-Down Proteomics. Methods in Molecular Biology (Clifton, N.J.). 1410: 121-33. PMID 26867742 DOI: 10.1007/978-1-4939-3524-6_8  0.84
2016 Hattori T, Lai D, Dementieva IS, Montaño SP, Kurosawa K, Zheng Y, Akin LR, Świst-Rosowska KM, Grzybowski AT, Koide A, Krajewski K, Strahl BD, Kelleher NL, Ruthenburg AJ, Koide S. Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 26862167 DOI: 10.1073/pnas.1522691113  0.92
2016 Chen Y, McClure RA, Kelleher NL. Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics. Methods in Molecular Biology (Clifton, N.J.). 1401: 135-47. PMID 26831706 DOI: 10.1007/978-1-4939-3375-4_9  0.84
2016 Durbin KR, Fornelli L, Fellers RT, Doubleday PF, Narita M, Kelleher NL. Quantitation and Identification of Thousands of Human Proteoforms Below 30 kDa. Journal of Proteome Research. PMID 26795204 DOI: 10.1021/acs.jproteome.5b00997  1
2016 Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, ... ... Kelleher NL, et al. An informatic framework for decoding protein complexes by top-down mass spectrometry. Nature Methods. PMID 26780093 DOI: 10.1038/nmeth.3731  0.4
2015 Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL. Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics. Eupa Open Proteomics. 8: 40-47. PMID 26753126 DOI: 10.1016/j.euprot.2015.05.005  0.96
2015 Compton PD, Fornelli L, Kelleher NL, Skinner OS. Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry. International Journal of Mass Spectrometry. 390: 132-136. PMID 26692813 DOI: 10.1016/j.ijms.2015.08.021  1
2015 Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS. A systems proteomics view of the endogenous human claudin protein family. Journal of Proteome Research. PMID 26680015 DOI: 10.1021/acs.jproteome.5b00769  0.92
2015 Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH. Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. Journal of Proteome Research. PMID 26595531 DOI: 10.1021/acs.jproteome.5b00675  1
2015 Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, et al. Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Nature Biotechnology. PMID 26571098 DOI: 10.1038/nbt.3372  1
2015 Ntai I, LeDuc RD, Fellers RT, Erdmann-Gilmore P, Davies SR, Rumsey J, Early BP, Thomas PM, Li S, Compton PD, Ellis MJ, Ruggles KV, Fenyo D, Boja ES, Rodriguez H, ... ... Kelleher NL, et al. Integrated Bottom-up and Top-down Proteomics of Patient-derived Breast Tumor Xenografts. Molecular & Cellular Proteomics : McP. PMID 26503891 DOI: 10.1074/mcp.M114.047480  0.4
2015 Rodrigues Lorenzatto K, Kim K, Ntai I, Prado Paludo G, Camargo de Lima J, Thomas PM, Kelleher NL, Ferreira HB. Top down proteomics reveals mature proteoforms expressed in subcellular fractions of the Echinococcus granulosus pre-adult stage. Journal of Proteome Research. PMID 26465659 DOI: 10.1021/acs.jproteome.5b00642  1
2015 LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, ... ... Kelleher NL, et al. Loss of BAP1 function leads to EZH2-dependent transformation. Nature Medicine. PMID 26437366 DOI: 10.1038/nm.3947  1
2015 Ye H, Wang J, Zhang Z, Jia C, Schmerberg CM, Catherman AD, Thomas PM, Kelleher NL, Li L. Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multi-Dimensional Mass Spectrometry-Based Platform. Journal of Proteome Research. PMID 26390183 DOI: 10.1021/acs.jproteome.5b00627  1
2015 Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL. Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression. Molecular & Cellular Proteomics : McP. PMID 26272979 DOI: 10.1074/mcp.M115.053819  0.4
2015 Skinner OS, Kelleher NL. Illuminating the dark matter of shotgun proteomics. Nature Biotechnology. 33: 717-8. PMID 26154010 DOI: 10.1038/nbt.3287  1
2015 Lee H, Le HV, Wu R, Doud E, Sanishvili R, Kellie JF, Compton PD, Pachaiyappan B, Liu D, Kelleher NL, Silverman RB. Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. Acs Chemical Biology. PMID 26110556 DOI: 10.1021/acschembio.5b00212  1
2015 Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL. Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. Journal of Proteomics. PMID 25952688 DOI: 10.1016/j.jprot.2015.04.025  1
2015 Bok JW, Ye R, Clevenger KD, Mead D, Wagner M, Krerowicz A, Albright JC, Goering AW, Thomas PM, Kelleher NL, Keller NP, Wu CC. Fungal artificial chromosomes for mining of the fungal secondary metabolome. Bmc Genomics. 16: 343. PMID 25925221 DOI: 10.1186/s12864-015-1561-x  1
2015 Tang W, Li H, Doud EH, Chen Y, Choing S, Plaza C, Kelleher NL, Poulos TL, Silverman RB. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid. Journal of the American Chemical Society. 137: 5980-9. PMID 25874809 DOI: 10.1021/jacs.5b01202  1
2015 Kim KH, Compton PD, Tran JC, Kelleher NL. Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry. Journal of Proteome Research. 14: 2199-206. PMID 25836738 DOI: 10.1021/pr501331q  1
2015 Fellers RT, Greer JB, Early BP, Yu X, LeDuc RD, Kelleher NL, Thomas PM. ProSight Lite: graphical software to analyze top-down mass spectrometry data. Proteomics. 15: 1235-8. PMID 25828799 DOI: 10.1002/pmic.201570050  1
2015 Albright JC, Henke MT, Soukup AA, McClure RA, Thomson RJ, Keller NP, Kelleher NL. Large-Scale Metabolomics Reveals a Complex Response of Aspergillus nidulans to Epigenetic Perturbation. Acs Chemical Biology. 10: 1535-41. PMID 25815712 DOI: 10.1021/acschembio.5b00025  1
2015 Le HV, Hawker DD, Wu R, Doud E, Widom J, Sanishvili R, Liu D, Kelleher NL, Silverman RB. Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators. Journal of the American Chemical Society. 137: 4525-33. PMID 25781189 DOI: 10.1021/jacs.5b01155  1
2015 Hong SH, Kwon YC, Martin RW, Des Soye BJ, de Paz AM, Swonger KN, Ntai I, Kelleher NL, Jewett MC. Improving cell-free protein synthesis through genome engineering of Escherichia coli lacking release factor 1. Chembiochem : a European Journal of Chemical Biology. 16: 844-53. PMID 25737329 DOI: 10.1002/cbic.201402708  1
2015 Durbin KR, Skinner OS, Fellers RT, Kelleher NL. Analyzing internal fragmentation of electrosprayed ubiquitin ions during beam-type collisional dissociation. Journal of the American Society For Mass Spectrometry. 26: 782-7. PMID 25716753 DOI: 10.1007/s13361-015-1078-1  1
2015 Skinner OS, Do Vale LH, Catherman AD, Havugimana PC, de Sousa MV, Compton PD, Kelleher NL. Native GELFrEE: a new separation technique for biomolecular assemblies. Analytical Chemistry. 87: 3032-8. PMID 25664979 DOI: 10.1021/ac504678d  1
2015 Lee H, Doud EH, Wu R, Sanishvili R, Juncosa JI, Liu D, Kelleher NL, Silverman RB. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115). Journal of the American Chemical Society. 137: 2628-40. PMID 25616005 DOI: 10.1021/ja512299n  1
2015 Dam DH, Lee H, Lee RC, Kim KH, Kelleher NL, Odom TW. Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method. Bioconjugate Chemistry. 26: 279-85. PMID 25564799 DOI: 10.1021/bc500562s  1
2015 Zheng H, Kim J, Liew M, Yan JK, Herrera O, Bok JW, Kelleher NL, Keller NP, Wang Y. Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus. Current Biology : Cb. 25: 29-37. PMID 25532893 DOI: 10.1016/j.cub.2014.11.018  1
2015 Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL. Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics Eupa Open Proteomics. DOI: 10.1016/j.euprot.2015.05.005  1
2014 Fellers RT, Greer JB, Early BP, Yu X, LeDuc RD, Kelleher NL, Thomas PM. ProSight Lite: Graphical software to analyze top-down mass spectrometry data. Proteomics. PMID 25504941 DOI: 10.1002/pmic.201400313  1
2014 Kelleher NL, Thomas PM, Ntai I, Compton PD, LeDuc RD. Deep and quantitative top-down proteomics in clinical and translational research. Expert Review of Proteomics. 11: 649-51. PMID 25347991 DOI: 10.1586/14789450.2014.976559  1
2014 Doroghazi JR, Albright JC, Goering AW, Ju KS, Haines RR, Tchalukov KA, Labeda DP, Kelleher NL, Metcalf WW. A roadmap for natural product discovery based on large-scale genomics and metabolomics. Nature Chemical Biology. 10: 963-8. PMID 25262415 DOI: 10.1038/nchembio.1659  1
2014 Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC, Hua Y, Bulic M, Jiang Y, Carrara M, Calogero RA, ... ... Kelleher NL, et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. Plos Genetics. 10: e1004566. PMID 25188243 DOI: 10.1371/journal.pgen.1004566  1
2014 LeDuc RD, Fellers RT, Early BP, Greer JB, Thomas PM, Kelleher NL. The C-score: a Bayesian framework to sharply improve proteoform scoring in high-throughput top down proteomics. Journal of Proteome Research. 13: 3231-40. PMID 24922115 DOI: 10.1021/pr401277r  1
2014 Zheng Y, Tipton JD, Thomas PM, Kelleher NL, Sweet SM. Site-specific human histone H3 methylation stability: fast K4me3 turnover. Proteomics. 14: 2190-9. PMID 24826939 DOI: 10.1002/pmic.201400060  1
2014 Ntai I, Kim K, Fellers RT, Skinner OS, Smith AD, Early BP, Savaryn JP, LeDuc RD, Thomas PM, Kelleher NL. Applying label-free quantitation to top down proteomics. Analytical Chemistry. 86: 4961-8. PMID 24807621 DOI: 10.1021/ac500395k  1
2014 Ye H, Mandal R, Catherman A, Thomas PM, Kelleher NL, Ikonomidou C, Li L. Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders. Plos One. 9: e92831. PMID 24710523 DOI: 10.1371/journal.pone.0092831  1
2014 Skinner OS, Catherman AD, Early BP, Thomas PM, Compton PD, Kelleher NL. Fragmentation of integral membrane proteins in the gas phase. Analytical Chemistry. 86: 4627-34. PMID 24689519 DOI: 10.1021/ac500864w  1
2014 Dang X, Scotcher J, Wu S, Chu RK, Tolić N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, ... ... Kelleher NL, et al. The first pilot project of the consortium for top-down proteomics: a status report. Proteomics. 14: 1130-40. PMID 24644084 DOI: 10.1002/pmic.201300438  1
2014 Li Y, Compton PD, Tran JC, Ntai I, Kelleher NL. Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins. Proteomics. 14: 1158-64. PMID 24596178 DOI: 10.1002/pmic.201300381  1
2014 Catherman AD, Skinner OS, Kelleher NL. Top Down proteomics: facts and perspectives. Biochemical and Biophysical Research Communications. 445: 683-93. PMID 24556311 DOI: 10.1016/j.bbrc.2014.02.041  1
2014 Cannon JR, Cammarata MB, Robotham SA, Cotham VC, Shaw JB, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS. Ultraviolet photodissociation for characterization of whole proteins on a chromatographic time scale. Analytical Chemistry. 86: 2185-92. PMID 24447299 DOI: 10.1021/ac403859a  1
2014 Durbin KR, Fellers RT, Ntai I, Kelleher NL, Compton PD. Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins. Analytical Chemistry. 86: 1485-92. PMID 24400813 DOI: 10.1021/ac402904h  1
2014 Hong SH, Ntai I, Haimovich AD, Kelleher NL, Isaacs FJ, Jewett MC. Cell-free protein synthesis from a release factor 1 deficient Escherichia coli activates efficient and multiple site-specific nonstandard amino acid incorporation. Acs Synthetic Biology. 3: 398-409. PMID 24328168 DOI: 10.1021/sb400140t  1
2014 Southey BR, Lee JE, Zamdborg L, Atkins N, Mitchell JW, Li M, Gillette MU, Kelleher NL, Sweedler JV. Comparing label-free quantitative peptidomics approaches to characterize diurnal variation of peptides in the rat suprachiasmatic nucleus. Analytical Chemistry. 86: 443-52. PMID 24313826 DOI: 10.1021/ac4023378  1
2014 Albright JC, Goering AW, Doroghazi JR, Metcalf WW, Kelleher NL. Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways. Journal of Industrial Microbiology & Biotechnology. 41: 451-9. PMID 24242000 DOI: 10.1007/s10295-013-1373-4  1
2014 Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, Allegretta M, Okot-Kotber CI, Patel JP, Melnick A, Levine RL, Ferrando A, Mackerell AD, Kelleher NL, Licht JD, et al. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia. 28: 198-201. PMID 23823660 DOI: 10.1038/leu.2013.204  1
2013 Belov ME, Damoc E, Denisov E, Compton PD, Horning S, Makarov AA, Kelleher NL. From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry. Analytical Chemistry. 85: 11163-73. PMID 24237199 DOI: 10.1021/ac4029328  1
2013 Catherman AD, Durbin KR, Ahlf DR, Early BP, Fellers RT, Tran JC, Thomas PM, Kelleher NL. Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence. Molecular & Cellular Proteomics : McP. 12: 3465-73. PMID 24023390 DOI: 10.1074/mcp.M113.030114  1
2013 Ahlf DR, Thomas PM, Kelleher NL. Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. Current Opinion in Chemical Biology. 17: 787-94. PMID 23988518 DOI: 10.1016/j.cbpa.2013.07.028  1
2013 Zheng Y, Thomas PM, Kelleher NL. Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Nature Communications. 4: 2203. PMID 23892279 DOI: 10.1038/ncomms3203  1
2013 Savaryn JP, Catherman AD, Thomas PM, Abecassis MM, Kelleher NL. The emergence of top-down proteomics in clinical research. Genome Medicine. 5: 53. PMID 23806018 DOI: 10.1186/gm457  1
2013 Li M, Durbin KR, Sweet SM, Tipton JD, Zheng Y, Kelleher NL. Oncogene-induced cellular senescence elicits an anti-Warburg effect. Proteomics. 13: 2585-96. PMID 23798001 DOI: 10.1002/pmic.201200298  1
2013 Chen Y, McClure RA, Zheng Y, Thomson RJ, Kelleher NL. Proteomics guided discovery of flavopeptins: anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase. Journal of the American Chemical Society. 135: 10449-56. PMID 23763305 DOI: 10.1021/ja4031193  1
2013 Yates JR, Kelleher NL. Top down proteomics. Analytical Chemistry. 85: 6151. PMID 23705843 DOI: 10.1021/ac401484r  1
2013 Shaw JB, Li W, Holden DD, Zhang Y, Griep-Raming J, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS. Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. Journal of the American Chemical Society. 135: 12646-51. PMID 23697802 DOI: 10.1021/ja4029654  1
2013 Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, ... ... Kelleher N, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 23: 677-92. PMID 23680150 DOI: 10.1016/j.ccr.2013.04.011  1
2013 Kelleher NL, Paša-Toli? L. 25th ASMS Sanibel Conference on Top Down Mass Spectrometry. Journal of the American Society For Mass Spectrometry. 24: 983-5. PMID 23673522 DOI: 10.1007/s13361-013-0640-y  1
2013 Kelleher NL. Status of mass spectrometry-based proteomics and metabolomics in basic and translational research. Biochemistry. 52: 3794-6. PMID 23614658 DOI: 10.1021/bi400466p  1
2013 Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart MD. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. Journal of the American Chemical Society. 135: 5962-5. PMID 23550886 DOI: 10.1021/ja400795m  1
2013 Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. Acs Chemical Biology. 8: 908-13. PMID 23474169 DOI: 10.1021/cb400102t  1
2013 Smith LM, Kelleher NL. Proteoform: a single term describing protein complexity. Nature Methods. 10: 186-7. PMID 23443629 DOI: 10.1038/nmeth.2369  1
2013 Chen Y, Unger M, Ntai I, McClure RA, Albright JC, Thomson RJ, Kelleher NL. Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using Proteomics. Medchemcomm. 4: 233-238. PMID 23336063 DOI: 10.1039/C2MD20232H  1
2013 Catherman AD, Li M, Tran JC, Durbin KR, Compton PD, Early BP, Thomas PM, Kelleher NL. Top down proteomics of human membrane proteins from enriched mitochondrial fractions. Analytical Chemistry. 85: 1880-8. PMID 23305238 DOI: 10.1021/ac3031527  1
2013 Lee JE, Zamdborg L, Southey BR, Atkins N, Mitchell JW, Li M, Gillette MU, Kelleher NL, Sweedler JV. Quantitative peptidomics for discovery of circadian-related peptides from the rat suprachiasmatic nucleus. Journal of Proteome Research. 12: 585-93. PMID 23256577 DOI: 10.1021/pr300605p  1
2013 Wu X, Vellaichamy A, Wang D, Zamdborg L, Kelleher NL, Huber SC, Zhao Y. Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics. Journal of Proteomics. 79: 60-71. PMID 23234799 DOI: 10.1016/j.jprot.2012.12.001  1
2013 Ezponda T, Popovic R, Shah MY, Martinez-Garcia E, Zheng Y, Min DJ, Will C, Neri A, Kelleher NL, Yu J, Licht JD. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene. 32: 2882-90. PMID 22797064 DOI: 10.1038/onc.2012.297  1
2012 Compton PD, Kelleher NL. Spinning up mass spectrometry for whole protein complexes. Nature Methods. 9: 1065-6. PMID 23132117 DOI: 10.1038/nmeth.2216  1
2012 Park S, Ntai I, Thomas P, Konishcheva E, Kelleher NL, Statsuk AV. Mechanism-based small molecule cross-linkers of HECT E3 ubiquitin ligase-substrate pairs. Biochemistry. 51: 8327-9. PMID 23043241 DOI: 10.1021/bi301231h  1
2012 Jia C, Hui L, Cao W, Lietz CB, Jiang X, Chen R, Catherman AD, Thomas PM, Ge Y, Kelleher NL, Li L. High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides. Molecular & Cellular Proteomics : McP. 11: 1951-64. PMID 23028060 DOI: 10.1074/mcp.M112.020537  1
2012 Kelleher NL. A cell-based approach to the human proteome project. Journal of the American Society For Mass Spectrometry. 23: 1617-24. PMID 22976808 DOI: 10.1007/s13361-012-0469-9  1
2012 Fornelli L, Damoc E, Thomas PM, Kelleher NL, Aizikov K, Denisov E, Makarov A, Tsybin YO. Analysis of intact monoclonal antibody IgG1 by electron transfer dissociation Orbitrap FTMS. Molecular & Cellular Proteomics : McP. 11: 1758-67. PMID 22964222 DOI: 10.1074/mcp.M112.019620  1
2012 Zheng Y, Sweet SM, Popovic R, Martinez-Garcia E, Tipton JD, Thomas PM, Licht JD, Kelleher NL. Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3. Proceedings of the National Academy of Sciences of the United States of America. 109: 13549-54. PMID 22869745 DOI: 10.1073/pnas.1205707109  1
2012 Romanova EV, Lee JE, Kelleher NL, Sweedler JV, Gulley JM. Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine. Journal of Neurochemistry. 123: 276-87. PMID 22860605 DOI: 10.1111/j.1471-4159.2012.07912.x  0.88
2012 Shvartsburg AA, Zheng Y, Smith RD, Kelleher NL. Separation of variant methylated histone tails by differential ion mobility. Analytical Chemistry. 84: 6317-20. PMID 22812477 DOI: 10.1021/ac301541r  1
2012 Ahlf DR, Compton PD, Tran JC, Early BP, Thomas PM, Kelleher NL. Evaluation of the compact high-field orbitrap for top-down proteomics of human cells. Journal of Proteome Research. 11: 4308-14. PMID 22746247 DOI: 10.1021/pr3004216  1
2012 Wu C, Tran JC, Zamdborg L, Durbin KR, Li M, Ahlf DR, Early BP, Thomas PM, Sweedler JV, Kelleher NL. A protease for 'middle-down' proteomics. Nature Methods. 9: 822-4. PMID 22706673 DOI: 10.1038/nmeth.2074  1
2012 Shvartsburg AA, Zheng Y, Smith RD, Kelleher NL. Ion mobility separation of variant histone tails extending to the "middle-down" range. Analytical Chemistry. 84: 4271-6. PMID 22559289 DOI: 10.1021/ac300612y  1
2012 Vagstad AL, Bumpus SB, Belecki K, Kelleher NL, Townsend CA. Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. Journal of the American Chemical Society. 134: 6865-77. PMID 22452347 DOI: 10.1021/ja3016389  1
2012 Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Lee JE, Kellie JF, Kelleher NL, Hendrickson CL, Marshall AG. Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa. Analytical Chemistry. 84: 2111-7. PMID 22356091 DOI: 10.1021/ac202651v  1
2012 Kellie JF, Catherman AD, Durbin KR, Tran JC, Tipton JD, Norris JL, Witkowski CE, Thomas PM, Kelleher NL. Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry. Analytical Chemistry. 84: 209-15. PMID 22103811 DOI: 10.1021/ac202384v  1
2012 Chen Y, Ntai I, Ju KS, Unger M, Zamdborg L, Robinson SJ, Doroghazi JR, Labeda DP, Metcalf WW, Kelleher NL. A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria. Journal of Proteome Research. 11: 85-94. PMID 21978092 DOI: 10.1021/pr2009115  1
2011 Mao Y, Zamdborg L, Kelleher NL, Hendrickson CL, Marshall AG. Identification of Phosphorylated Human Peptides by Accurate Mass Measurement Alone. International Journal of Mass Spectrometry. 308: 357-361. PMID 22866021 DOI: 10.1016/j.ijms.2011.08.006  1
2011 Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SM, Early BP, Siuti N, LeDuc RD, ... ... Kelleher NL, et al. Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature. 480: 254-8. PMID 22037311 DOI: 10.1038/nature10575  1
2011 Molohon KJ, Melby JO, Lee J, Evans BS, Dunbar KL, Bumpus SB, Kelleher NL, Mitchell DA. Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. Acs Chemical Biology. 6: 1307-13. PMID 21950656 DOI: 10.1021/cb200339d  1
2011 Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69. PMID 21899262 DOI: 10.1021/bi201302w  1
2011 Zhang W, Ntai I, Kelleher NL, Walsh CT. tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 108: 12249-53. PMID 21746899 DOI: 10.1073/pnas.1109539108  1
2011 Compton PD, Zamdborg L, Thomas PM, Kelleher NL. On the scalability and requirements of whole protein mass spectrometry. Analytical Chemistry. 83: 6868-74. PMID 21744800 DOI: 10.1021/ac2010795  1
2011 Tipton JD, Tran JC, Catherman AD, Ahlf DR, Durbin KR, Kelleher NL. Analysis of intact protein isoforms by mass spectrometry. The Journal of Biological Chemistry. 286: 25451-8. PMID 21632550 DOI: 10.1074/jbc.R111.239442  1
2011 Evans BS, Chen Y, Metcalf WW, Zhao H, Kelleher NL. Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo. Chemistry & Biology. 18: 601-7. PMID 21609841 DOI: 10.1016/j.chembiol.2011.03.008  1
2011 Evans BS, Ntai I, Chen Y, Robinson SJ, Kelleher NL. Proteomics-based discovery of koranimine, a cyclic imine natural product. Journal of the American Chemical Society. 133: 7316-9. PMID 21520944 DOI: 10.1021/ja2015795  1
2011 Hollenhorst MA, Ntai I, Badet B, Kelleher NL, Walsh CT. A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway. Biochemistry. 50: 3859-61. PMID 21520904 DOI: 10.1021/bi2004735  1
2011 Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT. Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. Journal of the American Chemical Society. 133: 5240-3. PMID 21417270 DOI: 10.1021/ja2011109  1
2011 Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood. 117: 211-20. PMID 20974671 DOI: 10.1182/blood-2010-07-298349  1
2011 Evans BS, Robinson SJ, Kelleher NL. Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo. Fungal Genetics and Biology : Fg & B. 48: 49-61. PMID 20601041 DOI: 10.1016/j.fgb.2010.06.012  1
2011 Kelleher NL. Foreword Rsc Chromatography Monographs. v-vi.  1
2010 Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM, Kelleher NL, Walsh CT. The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. Journal of the American Chemical Society. 132: 15773-81. PMID 20945916 DOI: 10.1021/ja1072367  1
2010 Durbin KR, Tran JC, Zamdborg L, Sweet SM, Catherman AD, Lee JE, Li M, Kellie JF, Kelleher NL. Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale. Proteomics. 10: 3589-97. PMID 20848673 DOI: 10.1002/pmic.201000177  1
2010 Kellie JF, Tran JC, Lee JE, Ahlf DR, Thomas HM, Ntai I, Catherman AD, Durbin KR, Zamdborg L, Vellaichamy A, Thomas PM, Kelleher NL. The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput. Molecular Biosystems. 6: 1532-9. PMID 20711533 DOI: 10.1039/c000896f  1
2010 Sweet SM, Li M, Thomas PM, Durbin KR, Kelleher NL. Kinetics of re-establishing H3K79 methylation marks in global human chromatin. The Journal of Biological Chemistry. 285: 32778-86. PMID 20699226 DOI: 10.1074/jbc.M110.145094  1
2010 Romanova EV, Lee JE, Kelleher NL, Sweedler JV, Gulley JM. Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine. The Aaps Journal. 12: 443-54. PMID 20490734 DOI: 10.1208/s12248-010-9204-2  0.88
2010 Zheng Y, John S, Pesavento JJ, Schultz-Norton JR, Schiltz RL, Baek S, Nardulli AM, Hager GL, Kelleher NL, Mizzen CA. Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II. The Journal of Cell Biology. 189: 407-15. PMID 20439994 DOI: 10.1083/jcb.201001148  1
2010 Johannes TW, DeSieno MA, Griffin BM, Thomas PM, Kelleher NL, Metcalf WW, Zhao H. Deciphering the late biosynthetic steps of antimalarial compound FR-900098. Chemistry & Biology. 17: 57-64. PMID 20142041 DOI: 10.1016/j.chembiol.2009.12.009  1
2010 Vellaichamy A, Tran JC, Catherman AD, Lee JE, Kellie JF, Sweet SM, Zamdborg L, Thomas PM, Ahlf DR, Durbin KR, Valaskovic GA, Kelleher NL. Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa. Analytical Chemistry. 82: 1234-44. PMID 20073486 DOI: 10.1021/ac9021083  1
2010 Lee JE, Atkins N, Hatcher NG, Zamdborg L, Gillette MU, Sweedler JV, Kelleher NL. Endogenous peptide discovery of the rat circadian clock: a focused study of the suprachiasmatic nucleus by ultrahigh performance tandem mass spectrometry. Molecular & Cellular Proteomics : McP. 9: 285-97. PMID 19955084 DOI: 10.1074/mcp.M900362-MCP200  0.92
2010 Siuti N, Kelleher NL. Efficient readout of posttranslational codes on the 50-residue tail of histone H3 by high-resolution MS/MS. Analytical Biochemistry. 396: 180-7. PMID 19761750 DOI: 10.1016/j.ab.2009.09.022  1
2010 Ntai I, Kelleher NL. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy Methodologies For Metabolomics: Experimental Strategies and Techniques. 174-184. DOI: 10.1017/CBO9780511996634.008  1
2009 Li M, Jiang L, Kelleher NL. Global histone profiling by LC-FTMS after inhibition and knockdown of deacetylases in human cells. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877: 3885-92. PMID 19828382 DOI: 10.1016/j.jchromb.2009.09.042  1
2009 Bumpus SB, Evans BS, Thomas PM, Ntai I, Kelleher NL. A proteomics approach to discovering natural products and their biosynthetic pathways. Nature Biotechnology. 27: 951-6. PMID 19767731 DOI: 10.1038/nbt.1565  1
2009 Lee JE, Kellie JF, Tran JC, Tipton JD, Catherman AD, Thomas HM, Ahlf DR, Durbin KR, Vellaichamy A, Ntai I, Marshall AG, Kelleher NL. A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome. Journal of the American Society For Mass Spectrometry. 20: 2183-91. PMID 19747844 DOI: 10.1016/j.jasms.2009.08.001  1
2009 Lee MV, Ihnken LA, You YO, McClerren AL, van der Donk WA, Kelleher NL. Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. Journal of the American Chemical Society. 131: 12258-64. PMID 19663480 DOI: 10.1021/ja9033507  1
2009 Evans BS, Kelleher NL. To cyclize or not to cyclize: catching enzyme evolution in the act. Acs Chemical Biology. 4: 495-7. PMID 19606882 DOI: 10.1021/cb900154b  1
2009 Ferguson JT, Wenger CD, Metcalf WW, Kelleher NL. Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans. Journal of the American Society For Mass Spectrometry. 20: 1743-50. PMID 19577935 DOI: 10.1016/j.jasms.2009.05.014  1
2009 Lee JH, Evans BS, Li G, Kelleher NL, van der Donk WA. In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis. Biochemistry. 48: 5054-6. PMID 19432442 DOI: 10.1021/bi900164d  1
2009 Yang XD, Huang B, Li M, Lamb A, Kelleher NL, Chen LF. Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. The Embo Journal. 28: 1055-66. PMID 19262565 DOI: 10.1038/emboj.2009.55  1
2009 Kalaitzis JA, Cheng Q, Thomas PM, Kelleher NL, Moore BS. In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides. Journal of Natural Products. 72: 469-72. PMID 19215142 DOI: 10.1021/np800598t  1
2009 Boyne MT, Garcia BA, Li M, Zamdborg L, Wenger CD, Babai S, Kelleher NL. Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval. Journal of Proteome Research. 8: 374-9. PMID 19053528 DOI: 10.1021/pr800635m  1
2008 Wenger CD, Boyne MT, Ferguson JT, Robinson DE, Kelleher NL. Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra. Analytical Chemistry. 80: 8055-63. PMID 18841935 DOI: 10.1021/ac8010704  1
2008 Mann M, Kelleher NL. Precision proteomics: the case for high resolution and high mass accuracy. Proceedings of the National Academy of Sciences of the United States of America. 105: 18132-8. PMID 18818311 DOI: 10.1073/pnas.0800788105  1
2008 Bora A, Annangudi SP, Millet LJ, Rubakhin SS, Forbes AJ, Kelleher NL, Gillette MU, Sweedler JV. Neuropeptidomics of the supraoptic rat nucleus. Journal of Proteome Research. 7: 4992-5003. PMID 18816085 DOI: 10.1021/pr800394e  1
2008 Calderone CT, Bumpus SB, Kelleher NL, Walsh CT, Magarvey NA. A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth. Proceedings of the National Academy of Sciences of the United States of America. 105: 12809-14. PMID 18723688 DOI: 10.1073/pnas.0806305105  1
2008 Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW. Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. Chemistry & Biology. 15: 765-70. PMID 18721747 DOI: 10.1016/j.chembiol.2008.07.010  1
2008 Hatcher NG, Atkins N, Annangudi SP, Forbes AJ, Kelleher NL, Gillette MU, Sweedler JV. Mass spectrometry-based discovery of circadian peptides. Proceedings of the National Academy of Sciences of the United States of America. 105: 12527-32. PMID 18719122 DOI: 10.1073/pnas.0804340105  1
2008 Bumpus SB, Kelleher NL. Accessing natural product biosynthetic processes by mass spectrometry. Current Opinion in Chemical Biology. 12: 475-82. PMID 18706516 DOI: 10.1016/j.cbpa.2008.07.022  1
2008 Garcia BA, Thomas CE, Kelleher NL, Mizzen CA. Tissue-specific expression and post-translational modification of histone H3 variants. Journal of Proteome Research. 7: 4225-36. PMID 18700791 DOI: 10.1021/pr800044q  1
2008 Bumpus SB, Magarvey NA, Kelleher NL, Walsh CT, Calderone CT. Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis. Journal of the American Chemical Society. 130: 11614-6. PMID 18693732 DOI: 10.1021/ja8040042  1
2008 Magarvey NA, Fortin PD, Thomas PM, Kelleher NL, Walsh CT. Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. Acs Chemical Biology. 3: 542-54. PMID 18652473 DOI: 10.1021/cb800085g  1
2008 Brodbelt JS, McLafferty FW, Kelleher NL. Focus in honor of Roman Zubarev, recipient of the 2007 Biemann Medal. Journal of the American Society For Mass Spectrometry. 19: 751-2. PMID 18499035 DOI: 10.1016/j.jasms.2008.04.021  1
2008 Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA. Deconstruction of iterative multidomain polyketide synthase function. Science (New York, N.Y.). 320: 243-6. PMID 18403714 DOI: 10.1126/science.1154711  1
2008 Pesavento JJ, Bullock CR, LeDuc RD, Mizzen CA, Kelleher NL. Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. The Journal of Biological Chemistry. 283: 14927-37. PMID 18381279 DOI: 10.1074/jbc.M709796200  1
2008 Roth MJ, Parks BA, Ferguson JT, Boyne MT, Kelleher NL. "Proteotyping": population proteomics of human leukocytes using top down mass spectrometry. Analytical Chemistry. 80: 2857-66. PMID 18351787 DOI: 10.1021/ac800141g  1
2008 Frank AM, Pesavento JJ, Mizzen CA, Kelleher NL, Pevzner PA. Interpreting top-down mass spectra using spectral alignment. Analytical Chemistry. 80: 2499-505. PMID 18302345 DOI: 10.1021/ac702324u  1
2008 Yang H, Pesavento JJ, Starnes TW, Cryderman DE, Wallrath LL, Kelleher NL, Mizzen CA. Preferential dimethylation of histone H4 lysine 20 by Suv4-20. The Journal of Biological Chemistry. 283: 12085-92. PMID 18296440 DOI: 10.1074/jbc.M707974200  1
2008 Zhang J, Van Lanen SG, Ju J, Liu W, Dorrestein PC, Li W, Kelleher NL, Shen B. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 1460-5. PMID 18223152 DOI: 10.1073/pnas.0711625105  1
2008 Krusemark CJ, Ferguson JT, Wenger CD, Kelleher NL, Belshaw PJ. Global amine and acid functional group modification of proteins. Analytical Chemistry. 80: 713-20. PMID 18184016 DOI: 10.1021/ac7019317  1
2008 Pesavento JJ, Yang H, Kelleher NL, Mizzen CA. Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Molecular and Cellular Biology. 28: 468-86. PMID 17967882 DOI: 10.1128/MCB.01517-07  1
2007 Leduc RD, Kelleher NL. Using ProSight PTM and related tools for targeted protein identification and characterization with high mass accuracy tandem MS data. Current Protocols in Bioinformatics / Editoral Board, Andreas D. Baxevanis ... [Et Al.]. Unit 13.6. PMID 18428787 DOI: 10.1002/0471250953.bi1306s19  1
2007 Astle J, Ferguson JT, German JB, Harrigan GG, Kelleher NL, Kodadek T, Parks BA, Roth MJ, Singletary KW, Wenger CD, Mahady GB. Characterization of proteomic and metabolomic responses to dietary factors and supplements. The Journal of Nutrition. 137: 2787-93. PMID 18029500  1
2007 Whitteck JT, Ni W, Griffin BM, Eliot AC, Thomas PM, Kelleher NL, Metcalf WW, van der Donk WA. Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angewandte Chemie (International Ed. in English). 46: 9089-92. PMID 17990255 DOI: 10.1002/anie.200703810  1
2007 Parks BA, Jiang L, Thomas PM, Wenger CD, Roth MJ, Boyne MT, Burke PV, Kwast KE, Kelleher NL. Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers. Analytical Chemistry. 79: 7984-91. PMID 17915963 DOI: 10.1021/ac070553t  1
2007 Siuti N, Kelleher NL. Decoding protein modifications using top-down mass spectrometry. Nature Methods. 4: 817-21. PMID 17901871 DOI: 10.1038/nmeth1097  1
2007 Hwang Y, Thompson PR, Wang L, Jiang L, Kelleher NL, Cole PA. A selective chemical probe for coenzyme A-requiring enzymes. Angewandte Chemie (International Ed. in English). 46: 7621-4. PMID 17768748 DOI: 10.1002/anie.200702485  1
2007 Calderone CT, Iwig DF, Dorrestein PC, Kelleher NL, Walsh CT. Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chemistry & Biology. 14: 835-46. PMID 17656320 DOI: 10.1016/j.chembiol.2007.06.008  1
2007 Jiang L, Smith JN, Anderson SL, Ma P, Mizzen CA, Kelleher NL. Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail. The Journal of Biological Chemistry. 282: 27923-34. PMID 17652096 DOI: 10.1074/jbc.M704194200  1
2007 Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW. Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nature Chemical Biology. 3: 480-5. PMID 17632514 DOI: 10.1038/nchembio.2007.9  1
2007 Zamdborg L, LeDuc RD, Glowacz KJ, Kim YB, Viswanathan V, Spaulding IT, Early BP, Bluhm EJ, Babai S, Kelleher NL. ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry. Nucleic Acids Research. 35: W701-6. PMID 17586823 DOI: 10.1093/nar/gkm371  1
2007 Pesavento JJ, Garcia BA, Streeky JA, Kelleher NL, Mizzen CA. Mild performic acid oxidation enhances chromatographic and top down mass spectrometric analyses of histones. Molecular & Cellular Proteomics : McP. 6: 1510-26. PMID 17569892 DOI: 10.1074/mcp.M600404-MCP200  1
2007 Garcia BA, Pesavento JJ, Mizzen CA, Kelleher NL. Pervasive combinatorial modification of histone H3 in human cells. Nature Methods. 4: 487-9. PMID 17529979 DOI: 10.1038/nmeth1052  1
2007 Hansen DB, Bumpus SB, Aron ZD, Kelleher NL, Walsh CT. The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity. Journal of the American Chemical Society. 129: 6366-7. PMID 17472382 DOI: 10.1021/ja070890j  1
2007 Yin J, Straight PD, Hrvatin S, Dorrestein PC, Bumpus SB, Jao C, Kelleher NL, Kolter R, Walsh CT. Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. Chemistry & Biology. 14: 303-12. PMID 17379145 DOI: 10.1016/j.chembiol.2007.01.006  1
2007 Kelly WL, Boyne MT, Yeh E, Vosburg DA, Galoni? DP, Kelleher NL, Walsh CT. Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. Biochemistry. 46: 359-68. PMID 17209546 DOI: 10.1021/bi061930j  1
2007 Garcia BA, Siuti N, Thomas CE, Mizzen CA, Kelleher NL. Characterization of neurohistone variants and post-translational modifications by electron capture dissociation mass spectrometry International Journal of Mass Spectrometry. 259: 184-196. DOI: 10.1016/j.ijms.2006.07.022  1
2006 Hemp J, Robinson DE, Ganesan KB, Martinez TJ, Kelleher NL, Gennis RB. Evolutionary migration of a post-translationally modified active-site residue in the proton-pumping heme-copper oxygen reductases. Biochemistry. 45: 15405-10. PMID 17176062 DOI: 10.1021/bi062026u  1
2006 Hicks LM, Moffitt MC, Beer LL, Moore BS, Kelleher NL. Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. Acs Chemical Biology. 1: 93-102. PMID 17163649 DOI: 10.1021/cb500007v  1
2006 Dorrestein PC, Kelleher NL. Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. Natural Product Reports. 23: 893-918. PMID 17119639 DOI: 10.1039/b511400b  1
2006 Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H. Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chemistry & Biology. 13: 1171-82. PMID 17113999 DOI: 10.1016/j.chembiol.2006.09.007  1
2006 McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA. Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proceedings of the National Academy of Sciences of the United States of America. 103: 17243-8. PMID 17085596 DOI: 10.1073/pnas.0606088103  1
2006 Karanam B, Jiang L, Wang L, Kelleher NL, Cole PA. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. The Journal of Biological Chemistry. 281: 40292-301. PMID 17065153 DOI: 10.1074/jbc.M608813200  1
2006 Dorrestein PC, Bumpus SB, Calderone CT, Garneau-Tsodikova S, Aron ZD, Straight PD, Kolter R, Walsh CT, Kelleher NL. Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry. 45: 12756-66. PMID 17042494 DOI: 10.1021/bi061169d  1
2006 Garneau-Tsodikova S, Dorrestein PC, Kelleher NL, Walsh CT. Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society. 128: 12600-1. PMID 17002325 DOI: 10.1021/ja063611l  1
2006 Chan YA, Boyne MT, Podevels AM, Klimowicz AK, Handelsman J, Kelleher NL, Thomas MG. Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proceedings of the National Academy of Sciences of the United States of America. 103: 14349-54. PMID 16983083 DOI: 10.1073/pnas.0603748103  1
2006 Romanova EV, Roth MJ, Rubakhin SS, Jakubowski JA, Kelley WP, Kirk MD, Kelleher NL, Sweedler JV. Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica. Journal of Mass Spectrometry : Jms. 41: 1030-40. PMID 16924592 DOI: 10.1002/jms.1060  0.8
2006 Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL. The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. Journal of the American Chemical Society. 128: 10386-7. PMID 16895402 DOI: 10.1021/ja0639362  1
2006 Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B. Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. The Journal of Biological Chemistry. 281: 29633-40. PMID 16887797 DOI: 10.1074/jbc.M605887200  1
2006 Garcia BA, Joshi S, Thomas CE, Chitta RK, Diaz RL, Busby SA, Andrews PC, Ogorzalek Loo RR, Shabanowitz J, Kelleher NL, Mizzen CA, Allis CD, Hunt DF. Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila. Molecular & Cellular Proteomics : McP. 5: 1593-609. PMID 16835217 DOI: 10.1074/mcp.M600086-MCP200  1
2006 Hicks LM, Balibar CJ, Walsh CT, Kelleher NL, Hillson NJ. Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry. Biophysical Journal. 91: 2609-19. PMID 16815901 DOI: 10.1529/biophysj.106.084848  1
2006 Pesavento JJ, Mizzen CA, Kelleher NL. Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4. Analytical Chemistry. 78: 4271-80. PMID 16808433 DOI: 10.1021/ac0600050  1
2006 Calderone CT, Kowtoniuk WE, Kelleher NL, Walsh CT, Dorrestein PC. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 103: 8977-82. PMID 16757561 DOI: 10.1073/pnas.0603148103  1
2006 Hicks LM, Mazur MT, Miller LM, Dorrestein PC, Schnarr NA, Khosla C, Kelleher NL. Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. Chembiochem : a European Journal of Chemical Biology. 7: 904-7. PMID 16642537 DOI: 10.1002/cbic.200500416  1
2006 Howarth M, Chinnapen DJ, Gerrow K, Dorrestein PC, Grandy MR, Kelleher NL, El-Husseini A, Ting AY. A monovalent streptavidin with a single femtomolar biotin binding site. Nature Methods. 3: 267-73. PMID 16554831 DOI: 10.1038/nmeth861  1
2006 Gatto GJ, Boyne MT, Kelleher NL, Walsh CT. Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster. Journal of the American Chemical Society. 128: 3838-47. PMID 16536560 DOI: 10.1021/ja0587603  1
2006 Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 45: 1537-46. PMID 16460000 DOI: 10.1021/bi052333k  1
2006 Boyne MT, Pesavento JJ, Mizzen CA, Kelleher NL. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. Journal of Proteome Research. 5: 248-53. PMID 16457589 DOI: 10.1021/pr050269n  1
2006 Thomas CE, Kelleher NL, Mizzen CA. Mass spectrometric characterization of human histone H3: a bird's eye view. Journal of Proteome Research. 5: 240-7. PMID 16457588 DOI: 10.1021/pr050266a  1
2006 Siuti N, Roth MJ, Mizzen CA, Kelleher NL, Pesavento JJ. Gene-specific characterization of human histone H2B by electron capture dissociation. Journal of Proteome Research. 5: 233-9. PMID 16457587 DOI: 10.1021/pr050268v  1
2006 Miller LM, Chatterjee C, van der Donk WA, Kelleher NL. The dehydratase activity of lacticin 481 synthetase is highly processive. Journal of the American Chemical Society. 128: 1420-1. PMID 16448091 DOI: 10.1021/ja057203d  1
2006 Du Y, Parks BA, Sohn S, Kwast KE, Kelleher NL. Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry. Analytical Chemistry. 78: 686-94. PMID 16448040 DOI: 10.1021/ac050993p  1
2006 Patrie SM, Ferguson JT, Robinson DE, Whipple D, Rother M, Metcalf WW, Kelleher NL. Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation. Molecular & Cellular Proteomics : McP. 5: 14-25. PMID 16236702 DOI: 10.1074/mcp.M500219-MCP200  1
2005 Chatterjee C, Miller LM, Leung YL, Xie L, Yi M, Kelleher NL, van der Donk WA. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. Journal of the American Chemical Society. 127: 15332-3. PMID 16262372 DOI: 10.1021/ja0543043  1
2005 Zabrouskov V, Senko MW, Du Y, Leduc RD, Kelleher NL. New and automated MSn approaches for top-down identification of modified proteins. Journal of the American Society For Mass Spectrometry. 16: 2027-38. PMID 16253516 DOI: 10.1016/j.jasms.2005.08.004  1
2005 Aron ZD, Dorrestein PC, Blackhall JR, Kelleher NL, Walsh CT. Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster. Journal of the American Chemical Society. 127: 14986-7. PMID 16248612 DOI: 10.1021/ja055247g  1
2005 McLoughlin SM, Kelleher NL. Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly. Journal of the American Chemical Society. 127: 14984-5. PMID 16248611 DOI: 10.1021/ja0555264  1
2005 McLoughlin SM, Mazur MT, Miller LM, Yin J, Liu F, Walsh CT, Kelleher NL. Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry. Biochemistry. 44: 14159-69. PMID 16245932 DOI: 10.1021/bi051202g  1
2005 Yin J, Straight PD, McLoughlin SM, Zhou Z, Lin AJ, Golan DE, Kelleher NL, Kolter R, Walsh CT. Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 15815-20. PMID 16236721 DOI: 10.1073/pnas.0507705102  1
2005 Miller LM, Mazur MT, McLoughlin SM, Kelleher NL. Parallel interrogation of covalent intermediates in the biosynthesis of gramicidin S using high-resolution mass spectrometry. Protein Science : a Publication of the Protein Society. 14: 2702-12. PMID 16195555 DOI: 10.1110/ps.051553705  1
2005 Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT. Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 13843-8. PMID 16162666 DOI: 10.1073/pnas.0506964102  1
2005 Kelleher NL, Hicks LM. Contemporary mass spectrometry for the direct detection of enzyme intermediates. Current Opinion in Chemical Biology. 9: 424-30. PMID 16129650 DOI: 10.1016/j.cbpa.2005.08.018  1
2005 Van Lanen SG, Dorrestein PC, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B. Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. Journal of the American Chemical Society. 127: 11594-5. PMID 16104723 DOI: 10.1021/ja052871k  1
2005 Frankel BA, Kruger RG, Robinson DE, Kelleher NL, McCafferty DG. Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. Biochemistry. 44: 11188-200. PMID 16101303 DOI: 10.1021/bi050141j  1
2005 Roth MJ, Forbes AJ, Boyne MT, Kim YB, Robinson DE, Kelleher NL. Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry. Molecular & Cellular Proteomics : McP. 4: 1002-8. PMID 15863400 DOI: 10.1074/mcp.M500064-MCP200  1
2005 Gatto GJ, McLoughlin SM, Kelleher NL, Walsh CT. Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme. Biochemistry. 44: 5993-6002. PMID 15835888 DOI: 10.1021/bi050230w  1
2005 Garneau S, Dorrestein PC, Kelleher NL, Walsh CT. Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. Biochemistry. 44: 2770-80. PMID 15723521 DOI: 10.1021/bi0476329  1
2005 Meng F, Forbes AJ, Miller LM, Kelleher NL. Detection and localization of protein modifications by high resolution tandem mass spectrometry. Mass Spectrometry Reviews. 24: 126-34. PMID 15389861 DOI: 10.1002/mas.20009  1
2005 Valaskovic GA, Kelleher NL. Miniaturized Formats for Efficient Liquid Chromatography Mass Spectrometry-Based Proteomics and Therapeutic Development Integrated Strategies For Drug Discovery Using Mass Spectrometry. 1-26. DOI: 10.1002/0471721034.ch1  1
2004 McLoughlin SM, Kelleher NL. Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin. Journal of the American Chemical Society. 126: 13265-75. PMID 15479080 DOI: 10.1021/ja0470867  1
2004 Du Y, Meng F, Patrie SM, Miller LM, Kelleher NL. Improved molecular weight-based processing of intact proteins for interrogation by quadrupole-enhanced FT MS/MS. Journal of Proteome Research. 3: 801-6. PMID 15359734 DOI: 10.1021/pr0499489  1
2004 Patrie SM, Charlebois JP, Whipple D, Kelleher NL, Hendrickson CL, Quinn JP, Marshall AG, Mukhopadhyay B. Construction of a hybrid quadrupole/Fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa. Journal of the American Society For Mass Spectrometry. 15: 1099-108. PMID 15234368 DOI: 10.1016/j.jasms.2004.04.031  1
2004 LeDuc RD, Taylor GK, Kim YB, Januszyk TE, Bynum LH, Sola JV, Garavelli JS, Kelleher NL. ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry. Nucleic Acids Research. 32: W340-5. PMID 15215407 DOI: 10.1093/nar/gkh447  1
2004 Kelleher NL. Top-down proteomics. Analytical Chemistry. 76: 197A-203A. PMID 15190879  1
2004 Meng F, Du Y, Miller LM, Patrie SM, Robinson DE, Kelleher NL. Molecular-level description of proteins from saccharomyces cerevisiae using quadrupole FT hybrid mass spectrometry for top down proteomics. Analytical Chemistry. 76: 2852-8. PMID 15144197 DOI: 10.1021/ac0354903  1
2004 Hicks LM, O'Connor SE, Mazur MT, Walsh CT, Kelleher NL. Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chemistry & Biology. 11: 327-35. PMID 15123262 DOI: 10.1016/j.chembiol.2004.02.021  1
2004 Pesavento JJ, Kim YB, Taylor GK, Kelleher NL. Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry. Journal of the American Chemical Society. 126: 3386-7. PMID 15025441 DOI: 10.1021/ja039748i  1
2004 Forbes AJ, Patrie SM, Taylor GK, Kim YB, Jiang L, Kelleher NL. Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS. Proceedings of the National Academy of Sciences of the United States of America. 101: 2678-83. PMID 14976258 DOI: 10.1073/pnas.0306575101  1
2004 Xie L, Miller LM, Chatterjee C, Averin O, Kelleher NL, van der Donk WA. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (New York, N.Y.). 303: 679-81. PMID 14752162 DOI: 10.1126/science.1092600  1
2004 Tseng CC, McLoughlin SM, Kelleher NL, Walsh CT. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. Biochemistry. 43: 970-80. PMID 14744141 DOI: 10.1021/bi035714b  1
2004 Patrie SM, Robinson DE, Meng F, Du Y, Kelleher NL. Strategies for automating top-down protein analysis with Q-FTICR MS International Journal of Mass Spectrometry. 234: 175-184. DOI: 10.1016/j.ijms.2004.02.020  1
2003 Taylor GK, Kim YB, Forbes AJ, Meng F, McCarthy R, Kelleher NL. Web and database software for identification of intact proteins using "top down" mass spectrometry. Analytical Chemistry. 75: 4081-6. PMID 14632120 DOI: 10.1021/ac0341721  1
2003 Mazur MT, Walsh CT, Kelleher NL. Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. Biochemistry. 42: 13393-400. PMID 14621984 DOI: 10.1021/bi035585z  1
2003 Charlebois JP, Patrie SM, Kelleher NL. Electron capture dissociation and 13C,15N depletion for deuterium localization in intact proteins after solution-phase exchange. Analytical Chemistry. 75: 3263-6. PMID 12964778 DOI: 10.1021/ac020690k  1
2002 Johnson JR, Meng F, Forbes AJ, Cargile BJ, Kelleher NL. Fourier-transform mass spectrometry for automated fragmentation and identification of 5-20 kDa proteins in mixtures. Electrophoresis. 23: 3217-23. PMID 12298093 DOI: 10.1002/1522-2683(200209)23:18<3217::AID-ELPS3217>3.0.CO;2-K  1
2002 Meng F, Cargile BJ, Patrie SM, Johnson JR, McLoughlin SM, Kelleher NL. Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. Analytical Chemistry. 74: 2923-9. PMID 12141648 DOI: 10.1021/ac020049i  1
2002 Valaskovic GA, Kelleher NL. Miniaturized formats for efficient mass spectrometry-based proteomics and therapeutic development. Current Topics in Medicinal Chemistry. 2: 1-12. PMID 11899062  0.48
2001 Forbes AJ, Mazur MT, Patel HM, Walsh CT, Kelleher NL. Toward efficient analysis of >70 kDa proteins with 100% sequence coverage. Proteomics. 1: 927-33. PMID 11683509 DOI: 10.1002/1615-9861(200108)1:8<927::AID-PROT927>3.0.CO;2-T  1
2001 Meng F, Cargile BJ, Miller LM, Forbes AJ, Johnson JR, Kelleher NL. Informatics and multiplexing of intact protein identification in bacteria and the archaea. Nature Biotechnology. 19: 952-7. PMID 11581661 DOI: 10.1038/nbt1001-952  1
2000 Zubarev RA, Horn DM, Fridriksson EK, Kelleher NL, Kruger NA, Lewis MA, Carpenter BK, McLafferty FW. Electron capture dissociation for structural characterization of multiply charged protein cations. Analytical Chemistry. 72: 563-73. PMID 10695143  1
1999 Kelleher NL, Hendrickson CL, Walsh CT. Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality. Biochemistry. 38: 15623-30. PMID 10569947 DOI: 10.1021/bi9913698  1
1999 Kelleher NL, Zubarev RA, Bush K, Furie B, Furie BC, McLafferty FW, Walsh CT. Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid. Analytical Chemistry. 71: 4250-3. PMID 10517147 DOI: 10.1021/ac990684x  1
1999 Shaw-Reid CA, Kelleher NL, Losey HC, Gehring AM, Berg C, Walsh CT. Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization. Chemistry & Biology. 6: 385-400. PMID 10375542 DOI: 10.1016/S1074-5521(99)80050-7  1
1999 Sinha Roy R, Kelleher NL, Milne JC, Walsh CT. In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites. Chemistry & Biology. 6: 305-18. PMID 10322125  1
1999 Milne JC, Roy RS, Eliot AC, Kelleher NL, Wokhlu A, Nickels B, Walsh CT. Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17. Biochemistry. 38: 4768-81. PMID 10200165 DOI: 10.1021/bi982975q  1
1998 Kinsland C, Taylor SV, Kelleher NL, McLafferty FW, Begley TP. Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis. Protein Science : a Publication of the Protein Society. 7: 1839-42. PMID 10082383 DOI: 10.1002/pro.5560070821  1
1998 Kelleher NL, Taylor SV, Grannis D, Kinsland C, Chiu HJ, Begley TP, McLafferty FW. Efficient sequence analysis of the six gene products (7-74 kDa) from the Escherichia coli thiamin biosynthetic operon by tandem high-resolution mass spectrometry. Protein Science : a Publication of the Protein Society. 7: 1796-801. PMID 10082377 DOI: 10.1002/pro.5560070815  1
1998 McLafferty FW, Kelleher NL, Begley TP, Fridriksson EK, Zubarev RA, Horn DM. Two-dimensional mass spectrometry of biomolecules at the subfemtomole level. Current Opinion in Chemical Biology. 2: 571-8. PMID 9818181  1
1998 Milne JC, Eliot AC, Kelleher NL, Walsh CT. ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17. Biochemistry. 37: 13250-61. PMID 9748332 DOI: 10.1021/bi980996e  1
1998 Belshaw PJ, Roy RS, Kelleher NL, Walsh CT. Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase. Chemistry & Biology. 5: 373-84. PMID 9662507  1
1998 Taylor SV, Kelleher NL, Kinsland C, Chiu HJ, Costello CA, Backstrom AD, McLafferty FW, Begley TP. Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation. The Journal of Biological Chemistry. 273: 16555-60. PMID 9632726 DOI: 10.1074/jbc.273.26.16555  1
1997 Kelleher NL, Nicewonger RB, Begley TP, McLafferty FW. Identification of modification sites in large biomolecules by stable isotope labeling and tandem high resolution mass spectrometry. The active site nucleophile of thiaminase I. The Journal of Biological Chemistry. 272: 32215-20. PMID 9405424 DOI: 10.1074/jbc.272.51.32215  1
1996 Aaserud DJ, Kelleher NL, Little DP, McLafferty FW. Accurate base composition of double-strand DNA by mass spectrometry. Journal of the American Society For Mass Spectrometry. 7: 1266-9. PMID 24203160 DOI: 10.1016/S1044-0305(96)00194-8  1
1996 Mørtz E, O'Connor PB, Roepstorff P, Kelleher NL, Wood TD, McLafferty FW, Mann M. Sequence tag identification of intact proteins by matching tanden mass spectral data against sequence data bases. Proceedings of the National Academy of Sciences of the United States of America. 93: 8264-7. PMID 8710858 DOI: 10.1073/pnas.93.16.8264  1
1996 Valaskovic GA, Kelleher NL, McLafferty FW. Attomole protein characterization by capillary electrophoresis-mass spectrometry. Science (New York, N.Y.). 273: 1199-202. PMID 8703047  1
1996 Costello CA, Kelleher NL, Abe M, McLafferty FW, Begley TP. Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile. The Journal of Biological Chemistry. 271: 3445-52. PMID 8631946 DOI: 10.1074/jbc.271.7.3445  1
1995 Kelleher NL, Senko MW, Little DP, O'Connor PB, McLafferty FW. Complete large-molecule high-resolution mass spectra from 50-femtomole microvolume injection. Journal of the American Society For Mass Spectrometry. 6: 220-1. PMID 24214121 DOI: 10.1016/1044-0305(95)00088-U  1
1995 Kelleher NL, Costello CA, Begley TP, McLafferty FW. Thiaminase I (42 kDa) heterogeneity, sequence refinement, and active site location from high-resolution tandem mass spectrometry. Journal of the American Society For Mass Spectrometry. 6: 981-4. PMID 24214043 DOI: 10.1016/1044-0305(95)00584-Z  1
1995 Wood TD, Chen LH, Kelleher NL, Little DP, Kenyon GL, McLafferty FW. Direct sequence data from heterogeneous creatine kinase (43 kDa) by high-resolution tandem mass spectrometry. Biochemistry. 34: 16251-4. PMID 8845349 DOI: 10.1021/bi00050a004  1
1995 Valaskovic GA, Kelleher NL, Little DP, Aaserud DJ, McLafferty FW. Attomole-sensitivity electrospray source for large-molecule mass spectrometry. Analytical Chemistry. 67: 3802-5. PMID 8644926  1
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