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Craig A. Townsend - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Organic and Bioorganic Chemistry
Website:
http://www.chemistry.jhu.edu/Townsend/biography.html

211 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Patel KD, d'Andrea FB, Gaudelli NM, Buller AR, Townsend CA, Gulick AM. Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions. Nature Communications. 10: 3868. PMID 31455765 DOI: 10.1038/s41467-019-11740-6  1
2019 d'Andrea FB, Townsend CA. Late-Stage Conversion of Diphenylphosphonate to Fluorophosphonate Probes for the Investigation of Serine Hydrolases. Cell Chemical Biology. PMID 30982751 DOI: 10.1016/j.chembiol.2019.02.020  0.4
2018 Storm PA, Pal P, Huitt-Roehl CR, Townsend CA. Exploring fungal polyketide C-methylation through combinatorial domain swaps. Acs Chemical Biology. PMID 30350943 DOI: 10.1021/acschembio.8b00429  0.56
2018 Herbst DA, Townsend CA, Maier T. The architectures of iterative type I PKS and FAS. Natural Product Reports. PMID 30137093 DOI: 10.1039/c8np00039e  0.52
2018 de Jonge R, Ebert MK, Huitt-Roehl CR, Pal P, Suttle JC, Spanner RE, Neubauer JD, Jurick WM, Stott KA, Secor GA, Thomma BPHJ, Van de Peer Y, Townsend CA, Bolton MD. Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus . Proceedings of the National Academy of Sciences of the United States of America. PMID 29844193 DOI: 10.1073/pnas.1712798115  0.52
2018 Saraiva RG, Huitt-Roehl CR, Tripathi A, Cheng YQ, Bosch J, Townsend CA, Dimopoulos G. Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin. Scientific Reports. 8: 6176. PMID 29670144 DOI: 10.1038/s41598-018-24296-0  0.52
2018 Herbst DA, Huitt-Roehl CR, Jakob RP, Kravetz JM, Storm PA, Alley JR, Townsend CA, Maier T. The structural organization of substrate loading in iterative polyketide synthases. Nature Chemical Biology. PMID 29610486 DOI: 10.1038/s41589-018-0026-3  0.56
2017 Storm PA, Townsend CA. In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis. Chemical Communications (Cambridge, England). PMID 29189834 DOI: 10.1039/c7cc07079a  0.56
2017 Oliver RA, Li R, Townsend CA. Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase. Nature Chemical Biology. PMID 29155429 DOI: 10.1038/nchembio.2526  0.68
2017 Horsman ME, Marous DR, Li R, Oliver RA, Byun B, Emrich SJ, Boggess B, Townsend CA, Mobashery S. Whole-Genome Shotgun Sequencing and Comparison of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster. Acs Chemical Biology. PMID 28937735 DOI: 10.1021/acschembio.7b00687  0.68
2017 Mattoo R, Lloyd EP, Kaushik A, Kumar P, Brunelle JL, Townsend CA, Lamichhane G. LdtMav2, a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems. Future Microbiology. PMID 28555497 DOI: 10.2217/fmb-2016-0208  0.68
2017 Bianchet MA, Pan YH, Basta LAB, Saavedra H, Lloyd EP, Kumar P, Mattoo R, Townsend CA, Lamichhane G. Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem. Bmc Biochemistry. 18: 8. PMID 28545389 DOI: 10.1186/s12858-017-0082-4  0.68
2017 Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484029 DOI: 10.1073/pnas.1609001114  0.84
2017 Storm PA, Herbst DA, Maier T, Townsend CA. Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Cell Chemical Biology. PMID 28238725 DOI: 10.1016/j.chembiol.2017.01.008  0.56
2016 Outlaw VK, Zhou J, Bragg AE, Townsend CA. Unusual Blue-Shifted Acid-Responsive Photoluminescence Behavior in 6-Amino-8-cyanobenzo[1,2-b]indolizines. Rsc Advances. 6: 61249-61253. PMID 28580137 DOI: 10.1039/C6RA10605F  0.6
2016 Li R, Oliver RA, Townsend CA. Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster. Cell Chemical Biology. PMID 28017601 DOI: 10.1016/j.chembiol.2016.11.010  0.68
2016 Kumar P, Kaushik A, Lloyd EP, Li SG, Mattoo R, Ammerman NC, Bell DT, Perryman AL, Zandi TA, Ekins S, Ginell SL, Townsend CA, Freundlich JS, Lamichhane G. Non-classical transpeptidases yield insight into new antibacterials. Nature Chemical Biology. PMID 27820797 DOI: 10.1038/nchembio.2237  0.68
2016 Townsend CA. Convergent biosynthetic pathways to β-lactam antibiotics. Current Opinion in Chemical Biology. 35: 97-108. PMID 27693891 DOI: 10.1016/j.cbpa.2016.09.013  1
2016 Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angewandte Chemie (International Ed. in English). PMID 27653519 DOI: 10.1002/anie.201605401  0.84
2016 Zhou J, Outlaw VK, Townsend CA, Bragg AE. Quenching of pH-Responsive Luminescence in a Benzoindolizine Sensor by Ultrafast Hydrogen Shift. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27549912 DOI: 10.1002/chem.201603284  0.6
2016 Newman AG, Townsend CA. Molecular Characterization of the Cercosporin Biosynthetic Pathway in the Fungal Plant Pathogen Cercospora nicotianae. Journal of the American Chemical Society. PMID 26938470 DOI: 10.1021/jacs.6b00633  1
2015 Brammer Basta LA, Ghosh A, Pan Y, Jean J, Lloyd EP, Townsend CA, Lamichhane G, Bianchet MA. Loss of a functionally and structurally distinct L,D-transpeptidase, LdtMt5, compromises cell wall integrity in Mycobacterium tuberculosis. The Journal of Biological Chemistry. PMID 26304120 DOI: 10.1074/jbc.M115.660753  1
2015 Conradt D, Schätzle MA, Haas J, Townsend CA, Müller M. New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1. Journal of the American Chemical Society. 137: 10867-9. PMID 26266881 DOI: 10.1021/jacs.5b06770  1
2015 Marous DR, Lloyd EP, Buller AR, Moshos KA, Grove TL, Blaszczyk AJ, Booker SJ, Townsend CA. Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 10354-8. PMID 26240322 DOI: 10.1073/pnas.1508615112  1
2015 Outlaw VK, d'Andrea FB, Townsend CA. One-pot synthesis of highly substituted N-fused heteroaromatic bicycles from azole aldehydes. Organic Letters. 17: 1822-5. PMID 25815402 DOI: 10.1021/ol5036936  1
2015 Huitt-Roehl CR, Hill EA, Adams MM, Vagstad AL, Li JW, Townsend CA. Starter Unit Flexibility for Engineered Product Synthesis by the Nonreducing Polyketide Synthase PksA. Acs Chemical Biology. 10: 1443-9. PMID 25714897 DOI: 10.1021/acschembio.5b00005  1
2015 Gaudelli NM, Long DH, Townsend CA. β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis. Nature. 520: 383-7. PMID 25624104 DOI: 10.1038/nature14100  1
2014 Outlaw VK, Townsend CA. A practical route to substituted 7-aminoindoles from pyrrole-3-carboxaldehydes. Organic Letters. 16: 6334-7. PMID 25479249 DOI: 10.1021/ol503078h  1
2014 Townsend CA. Aflatoxin and deconstruction of type I, iterative polyketide synthase function. Natural Product Reports. 31: 1260-5. PMID 25079257 DOI: 10.1039/c4np00092g  1
2014 Outlaw VK, Wydysh EA, Vadlamudi A, Medghalchi SM, Townsend CA. Design, Synthesis, and Evaluation of 4- and 5-Substituted o-(Octanesulfonamido)benzoic Acids as Inhibitors of Glycerol-3-Phosphate Acyltransferase. Medchemcomm. 5: 826-830. PMID 25068033 DOI: 10.1039/C4MD00126E  1
2014 Buller AR, Freeman MF, Schildbach JF, Townsend CA. Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT. Biochemistry. 53: 4273-81. PMID 24933323 DOI: 10.1021/bi500385d  1
2014 Newman AG, Vagstad AL, Storm PA, Townsend CA. Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming. Journal of the American Chemical Society. 136: 7348-62. PMID 24815013 DOI: 10.1021/ja5007299  1
2014 Gaudelli NM, Townsend CA. Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis. Nature Chemical Biology. 10: 251-8. PMID 24531841 DOI: 10.1038/nchembio.1456  1
2014 Li R, Lloyd EP, Moshos KA, Townsend CA. Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009. Chembiochem : a European Journal of Chemical Biology. 15: 320-31. PMID 24420617 DOI: 10.1002/cbic.201300319  1
2013 Townsend CA. Enzymology: Modular biosynthesis branches out. Nature. 502: 44-5. PMID 24048474 DOI: 10.1038/nature12562  1
2013 Belecki K, Townsend CA. Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8. Journal of the American Chemical Society. 135: 14339-48. PMID 24041368 DOI: 10.1021/ja406697t  1
2013 Bruegger J, Haushalter RW, Haushalter B, Vagstad AL, Vagstad A, Shakya G, Mih N, Townsend CA, Burkart MD, Tsai SC. Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chemistry & Biology. 20: 1135-46. PMID 23993461 DOI: 10.1016/j.chembiol.2013.07.012  1
2013 Gaudelli NM, Townsend CA. Stereocontrolled syntheses of peptide thioesters containing modified seryl residues as probes of antibiotic biosynthesis. The Journal of Organic Chemistry. 78: 6412-26. PMID 23758494 DOI: 10.1021/jo4007893  1
2013 Phelan RM, Townsend CA. Mechanistic insights into the bifunctional non-heme iron oxygenase carbapenem synthase by active site saturation mutagenesis. Journal of the American Chemical Society. 135: 7496-502. PMID 23611403 DOI: 10.1021/ja311078s  1
2013 Buller AR, Townsend CA. Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad. Proceedings of the National Academy of Sciences of the United States of America. 110: E653-61. PMID 23382230 DOI: 10.1073/pnas.1221050110  1
2013 Davidsen JM, Bartley DM, Townsend CA. Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI. Journal of the American Chemical Society. 135: 1749-59. PMID 23330869 DOI: 10.1021/ja307710d  1
2013 Vagstad AL, Newman AG, Storm PA, Belecki K, Crawford JM, Townsend CA. Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products. Angewandte Chemie (International Ed. in English). 52: 1718-21. PMID 23283670 DOI: 10.1002/anie.201208550  1
2013 Labonte JW, Townsend CA. Active site comparisons and catalytic mechanisms of the hot dog superfamily. Chemical Reviews. 113: 2182-204. PMID 23205964 DOI: 10.1021/cr300169a  1
2012 Labonte JW, Kudo F, Freeman MF, Raber ML, Townsend CA. Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics. Medchemcomm. 3: 960-966. PMID 23616913 DOI: 10.1039/C2MD00305H  1
2012 Vagstad AL, Hill EA, Labonte JW, Townsend CA. Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis. Chemistry & Biology. 19: 1525-34. PMID 23261597 DOI: 10.1016/j.chembiol.2012.10.002  1
2012 Newman AG, Vagstad AL, Belecki K, Scheerer JR, Townsend CA. Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function. Chemical Communications (Cambridge, England). 48: 11772-4. PMID 23108075 DOI: 10.1039/c2cc36010a  1
2012 Belecki K, Townsend CA. Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis. Angewandte Chemie (International Ed. in English). 51: 11316-9. PMID 23042574 DOI: 10.1002/anie.201206462  1
2012 Foulke-Abel J, Townsend CA. Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 13: 1880-4. PMID 22807303 DOI: 10.1002/cbic.201200267  1
2012 Buller AR, Labonte JW, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Autoproteolytic activation of ThnT results in structural reorganization necessary for substrate binding and catalysis. Journal of Molecular Biology. 422: 508-18. PMID 22706025 DOI: 10.1016/j.jmb.2012.06.012  1
2012 Vagstad AL, Bumpus SB, Belecki K, Kelleher NL, Townsend CA. Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. Journal of the American Chemical Society. 134: 6865-77. PMID 22452347 DOI: 10.1021/ja3016389  1
2012 Jensen K, Niederkrüger H, Zimmermann K, Vagstad AL, Moldenhauer J, Brendel N, Frank S, Pöplau P, Kohlhaas C, Townsend CA, Oldiges M, Hertweck C, Piel J. Polyketide proofreading by an acyltransferase-like enzyme. Chemistry & Biology. 19: 329-39. PMID 22444588 DOI: 10.1016/j.chembiol.2012.01.005  1
2012 Phelan RM, DiPardo BJ, Townsend CA. A high-throughput screen for the engineered production of β-lactam antibiotics. Acs Chemical Biology. 7: 835-40. PMID 22428872 DOI: 10.1021/cb200504g  1
2012 Davidsen JM, Townsend CA. In vivo characterization of nonribosomal peptide synthetases NocA and NocB in the biosynthesis of nocardicin A. Chemistry & Biology. 19: 297-306. PMID 22365611 DOI: 10.1016/j.chembiol.2011.10.020  1
2012 Buller AR, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement. Proceedings of the National Academy of Sciences of the United States of America. 109: 2308-13. PMID 22308359 DOI: 10.1073/pnas.1113633109  1
2011 Bodner MJ, Li R, Phelan RM, Freeman MF, Moshos KA, Lloyd EP, Townsend CA. Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis. Chembiochem : a European Journal of Chemical Biology. 12: 2159-65. PMID 21913298 DOI: 10.1002/cbic.201100366  1
2011 Townsend CA. A "diels-alderase" at last. Chembiochem : a European Journal of Chemical Biology. 12: 2267-9. PMID 21796752 DOI: 10.1002/cbic.201100431  1
2011 Kuhajda FP, Aja S, Tu Y, Han WF, Medghalchi SM, El Meskini R, Landree LE, Peterson JM, Daniels K, Wong K, Wydysh EA, Townsend CA, Ronnett GV. Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R116-30. PMID 21490364 DOI: 10.1152/ajpregu.00147.2011  1
2010 Crawford JM, Townsend CA. New insights into the formation of fungal aromatic polyketides. Nature Reviews. Microbiology. 8: 879-89. PMID 21079635 DOI: 10.1038/nrmicro2465  1
2010 Wydysh EA, Vadlamudi A, Medghalchi SM, Townsend CA. Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors. Bioorganic & Medicinal Chemistry. 18: 6470-9. PMID 20692840 DOI: 10.1016/j.bmc.2010.06.091  1
2010 Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6246-51. PMID 20332208 DOI: 10.1073/pnas.0913531107  1
2010 Ehrlich KC, Chang PK, Scharfenstein LL, Cary JW, Crawford JM, Townsend CA. Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures. Fems Microbiology Letters. 305: 65-70. PMID 20158523 DOI: 10.1111/j.1574-6968.2010.01914.x  1
2010 Bodner MJ, Phelan RM, Freeman MF, Li R, Townsend CA. Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics. Journal of the American Chemical Society. 132: 12-3. PMID 20017478 DOI: 10.1021/ja907320n  1
2009 Raber ML, Castillo A, Greer A, Townsend CA. A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 2904-12. PMID 19882698 DOI: 10.1002/cbic.200900389  1
2009 Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 461: 1139-43. PMID 19847268 DOI: 10.1038/nature08475  1
2009 Belecki K, Crawford JM, Townsend CA. Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures. Journal of the American Chemical Society. 131: 12564-6. PMID 19689130 DOI: 10.1021/ja904391r  1
2009 Bodner MJ, Phelan RM, Townsend CA. A catalytic asymmetric route to carbapenems. Organic Letters. 11: 3606-9. PMID 19610642 DOI: 10.1021/ol901269d  1
2009 Sohka T, Heins RA, Phelan RM, Greisler JM, Townsend CA, Ostermeier M. An externally tunable bacterial band-pass filter. Proceedings of the National Academy of Sciences of the United States of America. 106: 10135-40. PMID 19502423 DOI: 10.1073/pnas.0901246106  1
2009 Wydysh EA, Medghalchi SM, Vadlamudi A, Townsend CA. Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors. Journal of Medicinal Chemistry. 52: 3317-27. PMID 19388675 DOI: 10.1021/jm900251a  0.36
2009 Raber ML, Arnett SO, Townsend CA. A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase. Biochemistry. 48: 4959-71. PMID 19371088 DOI: 10.1021/bi900432n  1
2009 Phelan RM, Ostermeier M, Townsend CA. Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug. Bioorganic & Medicinal Chemistry Letters. 19: 1261-3. PMID 19167216 DOI: 10.1016/j.bmcl.2008.12.057  1
2009 Davidsen JM, Townsend CA. Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis. Journal of Bacteriology. 191: 1066-77. PMID 19028891 DOI: 10.1128/JB.01833-07  1
2009 Raber ML, Freeman MF, Townsend CA. Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase. The Journal of Biological Chemistry. 284: 207-17. PMID 18955494 DOI: 10.1074/jbc.M805390200  1
2008 Freeman MF, Moshos KA, Bodner MJ, Li R, Townsend CA. Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 11128-33. PMID 18678912 DOI: 10.1073/pnas.0804500105  1
2008 Townsend C. Peering inside the black box to find enzyme-bound intermediates. Nature Chemical Biology. 4: 390-1. PMID 18560428 DOI: 10.1038/nchembio0708-390  1
2008 Crawford JM, Vagstad AL, Ehrlich KC, Udwary DW, Townsend CA. Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases. Chembiochem : a European Journal of Chemical Biology. 9: 1559-63. PMID 18551496 DOI: 10.1002/cbic.200700659  1
2008 Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA. Deconstruction of iterative multidomain polyketide synthase function. Science (New York, N.Y.). 320: 243-6. PMID 18403714 DOI: 10.1126/science.1154711  1
2008 Crawford JM, Vagstad AL, Whitworth KP, Ehrlich KC, Townsend CA. Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect". Chembiochem : a European Journal of Chemical Biology. 9: 1019-23. PMID 18338425 DOI: 10.1002/cbic.200700702  1
2008 Crawford JM, Vagstad AL, Ehrlich KC, Townsend CA. Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. Bioorganic Chemistry. 36: 16-22. PMID 18215412 DOI: 10.1016/j.bioorg.2007.11.002  1
2008 Aja S, Landree LE, Kleman AM, Medghalchi SM, Vadlamudi A, McFadden JM, Aplasca A, Hyun J, Plummer E, Daniels K, Kemm M, Townsend CA, Thupari JN, Kuhajda FP, Moran TH, et al. Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 294: R352-61. PMID 18056987 DOI: 10.1152/ajpregu.00862.2006  1
2007 Merski M, Townsend CA. Observation of an acryloyl-thiamin diphosphate adduct in the first step of clavulanic acid biosynthesis. Journal of the American Chemical Society. 129: 15750-1. PMID 18052280 DOI: 10.1021/ja076704r  1
2007 Arnett SO, Gerratana B, Townsend CA. Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase. Biochemistry. 46: 9337-45. PMID 17658887 DOI: 10.1021/bi0618464  1
2007 Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T, Kim EK, Vadlamudi A, Medghalchi SM, El Meskini R, Ronnett GV, Townsend CA, Kuhajda FP. Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Research. 67: 2964-71. PMID 17409402 DOI: 10.1158/0008-5472.CAN-06-3439  1
2006 Crawford JM, Dancy BC, Hill EA, Udwary DW, Townsend CA. Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 16728-33. PMID 17071746 DOI: 10.1073/pnas.0604112103  1
2006 Townsend CA, Crawford JM, Bililign T. New images evoke FAScinating questions. Chemistry & Biology. 13: 349-51. PMID 16632247 DOI: 10.1016/j.chembiol.2006.04.001  1
2006 Li R, Townsend CA. Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metabolic Engineering. 8: 240-52. PMID 16530442 DOI: 10.1016/j.ymben.2006.01.003  1
2006 Müller U, van Assema F, Gunsior M, Orf S, Kremer S, Schipper D, Wagemans A, Townsend CA, Sonke T, Bovenberg R, Wubbolts M. Metabolic engineering of the E. coli L-phenylalanine pathway for the production of D-phenylglycine (D-Phg). Metabolic Engineering. 8: 196-208. PMID 16466681 DOI: 10.1016/j.ymben.2005.12.001  1
2006 Hughes MA, Silva JC, Geromanos SJ, Townsend CA. Quantitative proteomic analysis of drug-induced changes in mycobacteria. Journal of Proteome Research. 5: 54-63. PMID 16396495 DOI: 10.1021/pr050248t  1
2005 Hughes MA, McFadden JM, Townsend CA. New alpha-methylene-gamma-butyrolactones with antimycobacterial properties. Bioorganic & Medicinal Chemistry Letters. 15: 3857-9. PMID 16002282 DOI: 10.1016/j.bmcl.2005.05.119  1
2005 Henry KM, Townsend CA. Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites. Journal of the American Chemical Society. 127: 3724-33. PMID 15771506 DOI: 10.1021/ja0455188  1
2005 Henry KM, Townsend CA. Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin. Journal of the American Chemical Society. 127: 3300-9. PMID 15755146 DOI: 10.1021/ja045520z  1
2005 McFadden JM, Medghalchi SM, Thupari JN, Pinn ML, Vadlamudi A, Miller KI, Kuhajda FP, Townsend CA. Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase. Journal of Medicinal Chemistry. 48: 946-61. PMID 15715465 DOI: 10.1021/jm049389h  1
2005 Kelly WL, Townsend CA. Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis. Journal of Bacteriology. 187: 739-46. PMID 15629944 DOI: 10.1128/JB.187.2.739-746.2005  1
2004 Gerratana B, Arnett SO, Stapon A, Townsend CA. Carboxymethylproline synthase from Pectobacterium carotorova: a multifaceted member of the crotonase superfamily. Biochemistry. 43: 15936-45. PMID 15595850 DOI: 10.1021/bi0483662  1
2004 Parrish NM, Ko CG, Hughes MA, Townsend CA, Dick JD. Effect of n-octanesulphonylacetamide (OSA) on ATP and protein expression in Mycobacterium bovis BCG. The Journal of Antimicrobial Chemotherapy. 54: 722-9. PMID 15355939 DOI: 10.1093/jac/dkh408  1
2004 Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA. The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A. Chemistry & Biology. 11: 927-38. PMID 15271351 DOI: 10.1016/j.chembiol.2004.04.012  1
2004 Chiou CH, Lee LW, Owens SA, Whallon JH, Klomparens KL, Townsend CA, Linz JE. Distribution and sub-cellular localization of the aflatoxin enzyme versicolorin B synthase in time-fractionated colonies of Aspergillus parasiticus. Archives of Microbiology. 182: 67-79. PMID 15258720 DOI: 10.1007/s00203-004-0700-6  1
2004 Kelly WL, Townsend CA. Mutational analysis and characterization of nocardicin C-9' epimerase. The Journal of Biological Chemistry. 279: 38220-7. PMID 15252031 DOI: 10.1074/jbc.M405450200  1
2004 Townsend CA. Buruli toxin genes decoded. Proceedings of the National Academy of Sciences of the United States of America. 101: 1116-7. PMID 14745038 DOI: 10.1073/pnas.0307310101  1
2004 Gunsior M, Ravel J, Challis GL, Townsend CA. Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Biochemistry. 43: 663-74. PMID 14730970 DOI: 10.1021/bi035762w  1
2003 Stapon A, Li R, Townsend CA. Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem. Journal of the American Chemical Society. 125: 15746-7. PMID 14677956 DOI: 10.1021/ja037665w  1
2003 Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Research. 63: 7330-7. PMID 14612531  1
2003 Miller MT, Gerratana B, Stapon A, Townsend CA, Rosenzweig AC. Crystal structure of carbapenam synthetase (CarA). The Journal of Biological Chemistry. 278: 40996-1002. PMID 12890666 DOI: 10.1074/jbc.M307901200  1
2003 Stapon A, Li R, Townsend CA. Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline. Journal of the American Chemical Society. 125: 8486-93. PMID 12848554 DOI: 10.1021/ja034248a  1
2003 Gerratana B, Stapon A, Townsend CA. Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora. Biochemistry. 42: 7836-47. PMID 12820893 DOI: 10.1021/bi034361d  1
2002 McFadden JM, Frehywot GL, Townsend CA. A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis. Organic Letters. 4: 3859-62. PMID 12599477 DOI: 10.1021/ol026685k  1
2002 Townsend CA. New reactions in clavulanic acid biosynthesis. Current Opinion in Chemical Biology. 6: 583-9. PMID 12413541 DOI: 10.1016/S1367-5931(02)00392-7  1
2002 Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proceedings of the National Academy of Sciences of the United States of America. 99: 14752-7. PMID 12409610 DOI: 10.1073/pnas.232361199  1
2002 Udwary DW, Merski M, Townsend CA. A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. Journal of Molecular Biology. 323: 585-98. PMID 12381311 DOI: 10.1016/S0022-2836(02)00972-5  1
2002 Kim EK, Miller I, Landree LE, Borisy-Rudin FF, Brown P, Tihan T, Townsend CA, Witters LA, Moran TH, Kuhajda FP, Ronnett GV. Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. American Journal of Physiology. Endocrinology and Metabolism. 283: E867-79. PMID 12376313 DOI: 10.1152/ajpendo.00178.2002  1
2002 Watanabe CM, Townsend CA. Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1). Chemistry & Biology. 9: 981-8. PMID 12323372 DOI: 10.1016/S1074-5521(02)00213-2  1
2002 Kelly WL, Townsend CA. Role of the cytochrome P450 NocL in nocardicin A biosynthesis. Journal of the American Chemical Society. 124: 8186-7. PMID 12105888 DOI: 10.1021/ja025926g  1
2002 Udwary DW, Casillas LK, Townsend CA. Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis. Journal of the American Chemical Society. 124: 5294-303. PMID 11996570 DOI: 10.1021/ja012185v  1
2001 Hitchman TS, Schmidt EW, Trail F, Rarick MD, Linz JE, Townsend CA. Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis. Bioorganic Chemistry. 29: 293-307. PMID 16256699 DOI: 10.1006/bioo.2001.1216  1
2001 Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nature Structural Biology. 8: 684-9. PMID 11473258 DOI: 10.1038/90394  1
2001 Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI. Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities. Journal of the American Chemical Society. 123: 7388-98. PMID 11472170 DOI: 10.1021/ja004025+  1
2001 Parrish NM, Houston T, Jones PB, Townsend C, Dick JD. In vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis. Antimicrobial Agents and Chemotherapy. 45: 1143-50. PMID 11257028 DOI: 10.1128/AAC.45.4.1143-1150.2001  1
2000 Bachmann BO, Townsend CA. Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus. Biochemistry. 39: 11187-93. PMID 10985764 DOI: 10.1021/bi000709i  1
2000 Jones PB, Parrish NM, Houston TA, Stapon A, Bansal NP, Dick JD, Townsend CA. A new class of antituberculosis agents. Journal of Medicinal Chemistry. 43: 3304-14. PMID 10966749 DOI: 10.1021/jm000149l  1
2000 Khaleeli N, Busby RW, Townsend CA. Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant of the 2-His-1-carboxylate model. Biochemistry. 39: 8666-73. PMID 10913275 DOI: 10.1021/bi000534c  1
2000 Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science (New York, N.Y.). 288: 2379-81. PMID 10875926 DOI: 10.1126/science.288.5475.2379  1
2000 Li R, Khaleeli N, Townsend CA. Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. Journal of Bacteriology. 182: 4087-95. PMID 10869089 DOI: 10.1128/JB.182.14.4087-4095.2000  1
2000 Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL, Townsend CA. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proceedings of the National Academy of Sciences of the United States of America. 97: 3450-4. PMID 10716717 DOI: 10.1073/pnas.050582897  1
2000 Challis GL, Ravel J, Townsend CA. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chemistry & Biology. 7: 211-24. PMID 10712928 DOI: 10.1016/S1074-5521(00)00091-0  1
2000 Pizer ES, Thupari J, Han WF, Pinn ML, Chrest FJ, Frehywot GL, Townsend CA, Kuhajda FP. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Research. 60: 213-8. PMID 10667561  1
2000 Keller NP, Watanabe CM, Kelkar HS, Adams TH, Townsend CA. Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Applied and Environmental Microbiology. 66: 359-62. PMID 10618248  1
2000 Wu M, Stoermer D, Tullius TD, Townsend CA. Calicheamicin - Homeodomain conjugate as an efficient, sequence-specific DNA cleavage and mapping tool [11] Journal of the American Chemical Society. 122: 12884-12885. DOI: 10.1021/ja002280o  1
2000 Li R, Stapon A, Blanchfield JT, Townsend CA. Three unusual reactions mediate carbapenem and carbapenam biosynthesis [1] Journal of the American Chemical Society. 122: 9296-9297. DOI: 10.1021/ja001723l  1
1999 Casillas LK, Townsend CA. Total synthesis of O-methylsterigmatocystin using N-alkylnitrilium salts and carbonyl-alkene interconversion in a new xanthone synthesis Journal of Organic Chemistry. 64: 4050-4059. DOI: 10.1021/jo990099w  1
1999 Iwata-Reuyl D, Basak A, Townsend CA. β-Secondary kinetic isotope effects in the clavaminate synthase- catalyzed oxidative cyclization of proclavaminic acid and in related azetidinone model reactions Journal of the American Chemical Society. 121: 11356-11368. DOI: 10.1021/ja992649d  1
1999 Khaleeli N, Li R, Townsend CA. Origin of the β-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction [3] Journal of the American Chemical Society. 121: 9223-9224. DOI: 10.1021/ja9923134  1
1999 Graybill TL, Casillas EG, Pal K, Townsend CA. Silyl triflate-mediated ring-closure and rearrangement in the synthesis of potential bisfuran-containing intermediates of aflatoxin biosynthesis Journal of the American Chemical Society. 121: X. DOI: 10.1021/ja990591x  1
1998 Reeve AM, Breazeale SD, Townsend CA. Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis. The Journal of Biological Chemistry. 273: 30695-703. PMID 9804844 DOI: 10.1074/jbc.273.46.30695  1
1998 Bachmann BO, Li R, Townsend CA. beta-Lactam synthetase: a new biosynthetic enzyme. Proceedings of the National Academy of Sciences of the United States of America. 95: 9082-6. PMID 9689037 DOI: 10.1073/pnas.95.16.9082  1
1998 Zhou J, Gunsior M, Bachmann BO, Townsend CA, Solomon EI. Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation [14] Journal of the American Chemical Society. 120: 13539-13540. DOI: 10.1021/ja983534x  1
1998 Watanabe CMH, Townsend CA. The in vitro conversion of norsolorinic acid to aflatoxin B1. An improved method of cell-free enzyme preparation and stabilization Journal of the American Chemical Society. 120: 6231-6239. DOI: 10.1021/ja974367o  1
1998 Pavel EG, Zhou J, Busby RW, Gunsior M, Townsend CA, Solomon EI. Circular dichroism and magnetic circular dichroism spectroscopic studies of the non-heme ferrous active site in clavaminate synthase and its interaction with α-ketoglutarate cosubstrate Journal of the American Chemical Society. 120: 743-753. DOI: 10.1021/ja972408a  1
1998 Reeve AM, Townsend CA. Inhibitors of an AdoMet-dependent 3-amino-3-carboxypropyl transferase and their use as ligands for protein affinity chromatography Tetrahedron. 54: 15959-15974.  1
1998 Townsend CA. Alastair Ian Scott: Preface Tetrahedron. 54: VII.  1
1997 Minto RE, Townsend CA. Enzymology and Molecular Biology of Aflatoxin Biosynthesis. Chemical Reviews. 97: 2537-2556. PMID 11851470  1
1997 Mani NS, Townsend CA. A Concise Synthesis of (+)-Cerulenin from a Chiral Oxiranyllithium. The Journal of Organic Chemistry. 62: 636-640. PMID 11671457 DOI: 10.1021/jo9618177  1
1997 Townsend CA. Structural studies of natural product biosynthetic proteins. Chemistry & Biology. 4: 721-30. PMID 9375250  1
1997 Miller AF, Egan LA, Townsend CA. Measurement of the degree of coupled isotopic enrichment of different positions in an antibiotic peptide by NMR. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 125: 120-31. PMID 9245367 DOI: 10.1006/jmre.1997.1107  1
1997 Silva JC, Townsend CA. Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway. The Journal of Biological Chemistry. 272: 804-13. PMID 8995367 DOI: 10.1074/jbc.272.2.804  1
1997 Egan LA, Busby RW, Iwata-Reuyl D, Townsend CA. Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites Journal of the American Chemical Society. 119: 2348-2355. DOI: 10.1021/ja963107o  1
1997 Pitlik J, Townsend CA. Solution-phase synthesis of a combinatorial monocyclic β-lactam library: Potential protease inhibitors Bioorganic and Medicinal Chemistry Letters. 7: 3129-3134. DOI: 10.1016/S0960-894X(97)10170-6  1
1997 Pitlik J, Townsend CA. Efficient syntheses of multiple 2H- and 13C-labeled acrylic acid, glyceric acid, glycidic acid and glycerol Journal of Labelled Compounds and Radiopharmaceuticals. 39: 999-1009. DOI: 10.1002/(SICI)1099-1344(199712)39:12<999::AID-JLCR45>3.0.CO;2-Q  1
1997 Pitlik J, Townsend CA. The fate of [2,3,3-2H3,1,2-13C2]-D,L-glycerate in clavulanic acid biosynthesis Chemical Communications. 225-226.  1
1996 Busby RW, Townsend CA. A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations. Bioorganic & Medicinal Chemistry. 4: 1059-64. PMID 8831977 DOI: 10.1016/0968-0896(96)00088-0  1
1996 Watanabe CM, Wilson D, Linz JE, Townsend CA. Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1. Chemistry & Biology. 3: 463-9. PMID 8807876  1
1996 McGuire SM, Silva JC, Casillas EG, Townsend CA. Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiating cyclization in aflatoxin biosynthesis essential to DNA interaction. Biochemistry. 35: 11470-86. PMID 8784203 DOI: 10.1021/bi960924s  1
1996 Silva JC, Minto RE, Barry CE, Holland KA, Townsend CA. Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster. The Journal of Biological Chemistry. 271: 13600-8. PMID 8662689  1
1996 Watanabe CMH, Townsend CA. Incorporation of molecular oxygen in aflatoxin B1 biosynthesis Journal of Organic Chemistry. 61: 1990-1993. DOI: 10.1021/jo952056v  1
1996 Chatterjee M, Smith PJ, Townsend CA. The role of the aminosugar and helix binding in the thiol-induced activation of calicheamicin for DNA cleavage Journal of the American Chemical Society. 118: 1938-1948. DOI: 10.1021/ja953162h  1
1995 Janc JW, Egan LA, Townsend CA. Purification and characterization of clavaminate synthase from Streptomyces antibioticus. A multifunctional enzyme of clavam biosynthesis. The Journal of Biological Chemistry. 270: 5399-404. PMID 7890654  1
1995 Busby RW, Chang MD, Busby RC, Wimp J, Townsend CA. Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification. The Journal of Biological Chemistry. 270: 4262-9. PMID 7876185  1
1995 Kuduvalli PN, Townsend CA, Tullius TD. Cleavage by calicheamicin gamma 1I of DNA in a nucleosome formed on the 5S RNA gene of Xenopus borealis. Biochemistry. 34: 3899-906. PMID 7696253  1
1995 Wu TK, Busby RW, Houston TA, McIlwaine DB, Egan LA, Townsend CA. Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis. Journal of Bacteriology. 177: 3714-20. PMID 7601835  1
1995 Chatterjee M, Mah SC, Tullius TD, Townsend CA. Role of the aryl iodide in the sequence-selective cleavage of DNA by calicheamicin. Importance of thermodynamic binding vs kinetic activation in the cleavage process Journal of the American Chemical Society. 117: 8074-8082. DOI: 10.1021/ja00136a004  1
1994 Mah SC, Townsend CA, Tullius TD. Hydroxyl radical footprinting of calicheamicin. Relationship of DNA binding to cleavage. Biochemistry. 33: 614-21. PMID 8286393  1
1994 Chatterjee M, Cramer KD, Townsend CA. Kinetic vs thermodynamic determinants in the sequence selectivity of DNA cleavage by calicheamicin Journal of the American Chemical Society. 116: 8819-8820. DOI: 10.1021/ja00098a056  1
1994 Mah SC, Price MA, Townsend CA, Tullius TD. Features of DNA recognition for oriented binding and cleavage by calicheamicin Tetrahedron. 50: 1361-1378. DOI: 10.1016/S0040-4020(01)80624-4  1
1994 De Voss JJ, Hangeland JJ, Townsend CA. General approach to the synthesis of specifically deuterium-labeled nucleosides Journal of Organic Chemistry. 59: 2715-2723.  1
1994 Chatterjee M, Townsend CA. Evidence for the probable final steps in aflatoxin biosynthesis Journal of Organic Chemistry. 59: 4424-4429.  1
1993 Townsend CA. Oxidative amino aid processing in beta-lactam antibiotic biosynthesis. Biochemical Society Transactions. 21: 208-13. PMID 8449295  1
1993 Iwata-Reuyl D, Basak A, Silverman LS, Engle CA, Townsend CA. Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase. Journal of Natural Products. 56: 1373-96. PMID 8229018  1
1993 McIlwaine DB, Townsend CA. Evidence for distinct mechanisms of monocyclic β-lactam biosynthesis Journal of the Chemical Society, Chemical Communications. 1346-1347. DOI: 10.1039/C39930001346  1
1993 McGuire SM, Townsend CA. Demonstration of Baeyer-Villiger oxidation and the course of cyclization in bisfuran ring formation during aflatoxin B1 biosynthesis Bioorganic and Medicinal Chemistry Letters. 3: 653-656. DOI: 10.1016/S0960-894X(01)81247-6  1
1993 Janc JW, Egan LA, Townsend CA. Emerging evidence for a shared biosynthetic pathway among clavulanic acid and the structurally diverse clavam metabolites Bioorganic and Medicinal Chemistry Letters. 3: 2313-2316. DOI: 10.1016/S0960-894X(01)80946-X  1
1993 Chatterjee M, Cramer KD, Townsend CA. Kinetic nature of thiol activation in DNA cleavage by calicheamicin Journal of the American Chemical Society. 115: 3374-3375.  1
1992 Marsh EN, Chang MD, Townsend CA. Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry. 31: 12648-57. PMID 1472501  1
1992 Iwata-Reuyl D, Townsend CA. Common origin of clavulanic acid and other clavan metabolites in Streptomyces Journal of the American Chemical Society. 114: 2762-2763. DOI: 10.1021/ja00033a086  1
1991 Salowe SP, Krol WJ, Iwata-Reuyl D, Townsend CA. Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction. Biochemistry. 30: 2281-92. PMID 1998687  1
1991 Cramer KD, Townsend CA. Kinetics of trisulfide cleavage in calicheamicin-assessing the role of the ethylamino group Tetrahedron Letters. 32: 4635-4638. DOI: 10.1016/S0040-4039(00)92268-8  1
1991 Townsend CA, Basak A. Experiments and speculations on the role of oxidative cyclization chemistry in natural product biosynthesis Tetrahedron. 47: 2591-2602. DOI: 10.1016/S0040-4020(01)81792-0  1
1991 Krol WJ, Mao SS, Steele DL, Townsend CA. Stereochemical correlation of proclavaminic acid and syntheses of erythro- and threo-L-β-hydroxyornithine from an improved vinylglycine synthon Journal of Organic Chemistry. 56: 728-731.  1
1990 Salowe SP, Marsh EN, Townsend CA. Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis. Biochemistry. 29: 6499-508. PMID 2207091  1
1990 De Voss JJ, Townsend CA, Ding WD, Morton GO, Ellestad GA, Zein N, Tabor AB, Schreiber SL. Site-specific atom transfer from DNA to a bound ligand defines the geometry of a DNA-calicheamicin λ1 I complex Journal of the American Chemical Society. 112: 9669-9670.  1
1990 De Voss JJ, Hangeland JJ, Townsend CA. Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to DNA cleavage Journal of the American Chemical Society. 112: 4554-4556.  1
1990 Salituro GM, Townsend CA. Total syntheses of (-)-nocardicins A-G: A biogenetic approach Journal of the American Chemical Society. 112: 760-770.  1
1990 Basak A, Salowe SP, Townsend CA. Stereochemical course of the key ring-forming reactions in clavulanic acid biosynthesis Journal of the American Chemical Society. 112: 1654-1656.  1
1989 Townsend CA, Isomura Y, Davis SG, Hodge JA. Reaction Models of the Oxidative Rearrangement of Averufin to 1'- Hydroxyversicolorone: The First Step in Dihydrobisfuran Formation in Aflatoxin Biosynthesis Tetrahedron. 45: 2263-2276. DOI: 10.1016/S0040-4020(01)83431-1  1
1989 Graybill TL, Pal K, McGuire SM, Brobst SW, Townsend CA. The timing of aromatic deoxygenation in aflatoxin biosynthesis Journal of the American Chemical Society. 111: 8306-8308.  1
1989 Krol WJ, Basak A, Salowe SP, Townsend CA. Oxidative cyclization chemistry catalyzed by clavaminate synthase Journal of the American Chemical Society. 111: 7625-7627.  1
1989 McGuire SM, Brobst SW, Graybill TL, Pal K, Townsend CA. Partitioning of tetrahydro- and dihydrobisfuran formation in aflatoxin biosynthesis defined by cell-free and direct incorporation experiments Journal of the American Chemical Society. 111: 8308-8309.  1
1988 Townsend CA, Reeve AM, Salituro GM. Stereochemical fate of (2S,4R)- and (2S,4S)-[4-2H]methionine in nocardicin A biosynthesis Journal of the Chemical Society, Chemical Communications. 1579-1581. DOI: 10.1039/C39880001579  1
1988 Townsend CA, Krol WJ. The role of molecular oxygen in clavulanic acid biosynthesis: Evidence for a bacterial oxidative deamination Journal of the Chemical Society, Chemical Communications. 1234-1236. DOI: 10.1039/C39880001234  1
1988 Townsend CA, Whittamore PRO, Brobst SW. Hydroxyversicolorone: Synthesis and incorporation of a new intermediate in aflatoxin biosynthesis Journal of the Chemical Society, Chemical Communications. 726-728. DOI: 10.1039/C39880000726  1
1988 Wilson BA, Bantia S, Salituro GM, Reeve AM, Townsend CA. Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine Journal of the American Chemical Society. 110: 8238-8239.  1
1988 Townsend CA, Plavcan KA, Pal K, Brobst SW, Irish MS, Ely EW, Bennett JW. Hydroxyversicolorone: Isolation and characterization of a potential intermediate in aflatoxin biosynthesis Journal of Organic Chemistry. 53: 2472-2477.  1
1988 Townsend CA, Wilson BA. The role of nocardicin G in nocardicin A biosynthesis Journal of the American Chemical Society. 110: 3320-3321.  1
1988 Townsend CA, Christensen SB, Davis SG. Synthesis of averufin and its role in aflatoxin B1 biosynthesis Journal of the Chemical Society, Perkin Transactions 1. 839-861.  1
1988 Townsend CA, Brobst SW, Ramer SE, Vederas JC. Stereochemical features of enoyl thiol ester reductase in averufin and fatty acid biosynthesis in Aspergillus parasiticus Journal of the American Chemical Society. 110: 318-319.  1
1987 Townsend CA, Mao SS. Clavulanic acid biosynthesis: The stereochemical course of β-lactam formation from chiral glycerol Journal of the Chemical Society, Chemical Communications. 86-89. DOI: 10.1039/C39870000086  1
1986 Townsend CA. Progress toward a biosynthetic rationale of the aflatoxin pathway Pure and Applied Chemistry. 58: 227-238. DOI: 10.1351/pac198658020227  1
1986 Townsend CA, Ho MF, Mao SS. The stereochemical fate of (2RS,5R)- and (2RS,5S)-[5-3H] ornithine in clavulanic acid biosynthesis Journal of the Chemical Society, Chemical Communications. 638-639. DOI: 10.1039/C39860000638  1
1986 Townsend CA, Christensen SB. Stereochemical correlation of (-)-averantin Tetrahedron Letters. 27: 887-888. DOI: 10.1016/S0040-4039(00)84128-3  1
1986 Townsend CA, Salituro GM, Nguyen LT, DiNovi MJ. Biogenetically-modelled total syntheses (-)-nocardicin A and (-)-nocardicin G Tetrahedron Letters. 27: 3819-3822. DOI: 10.1016/S0040-4039(00)83888-5  1
1986 Schwab JM, Ho CK, Li WB, Townsend CA, Salituro GM. β-Hydroxydecanoyl thioester dehydrase. Complete characterization of the fate of the "suicide" substrate 3-decynoyl-NAC Journal of the American Chemical Society. 108: 5309-5316.  1
1985 Townsend CA. The stereochemical fate of chiral-methyl valines in cephalosporin C biosynthesis. Journal of Natural Products. 48: 708-24. PMID 4078571  1
1985 Townsend CA, Theis AB, Neese AS, Barrabee EB, Poland D. Stereochemical fate of chiral-methyl valine in the ring expansion of penicillin N to deacetoxycephalosporin C Journal of the American Chemical Society. 107: 4760-4767.  1
1985 Townsend CA, Ho MF. Biosynthesis of clavulanic acid: Origin of the C3 unit Journal of the American Chemical Society. 107: 1066-1068.  1
1985 Townsend CA, Ho MF. Biosynthesis of clavulanic acid: Origin of the C5 unit Journal of the American Chemical Society. 107: 1065-1066.  1
1985 Townsend CA, Davis SG, Koreeda M, Hulin B. A cationic model of the chain-branching step in aflatoxin biosynthesis Journal of Organic Chemistry. 50: 5428-5430.  1
1985 Townsend CA, Christensen SB. Concerning the role of nidurufin in aflatoxin biosynthesis Journal of the American Chemical Society. 107: 270-271.  1
1975 Scott IA, Georgopapadakou N, Ho KS, Klioze S, Lee E, Lee SL Temme GH, Townsend CA, Armitage IM. Letter: Concerning the intermediacy of uro'gen III and of a heptacarboxylic uro'gen in corrinoid biosynthesis. Journal of the American Chemical Society. 97: 2548-50. PMID 1133422  1
1974 Scott AI, Townsend CA, Okada K, Kajiwara M, Cushley RJ, Whitman PJ. Biosynthesis of corrins. II. Incorporation of 13C-labeled substrates in vitamins B12. Journal of the American Chemical Society. 96: 8069-80. PMID 4464318  1
1974 Scott AI, Townsend CA, Okada K, Kajiwara M. Biosynthesis of corrins. I. Experiments with 14-C porphobilinogen and 14-C uroporphyrinogens. Journal of the American Chemical Society. 96: 8054-69. PMID 4464317  0.4
1973 Scott AI, Townsend CA, Cushley RJ. Stereochemistry of methyl group insertion in corrinoid biosynthesis. Determination of carbon isotope chirality by 13C nuclear magnetic resonance. Journal of the American Chemical Society. 95: 5759-61. PMID 4733816  0.4
1973 Scott AI, Townsend CA, Okada K, Kajiwara M. Concerning the biosynthesis of vitamin B12. Transactions of the New York Academy of Sciences. 35: 72-9. PMID 4509732  0.4
1972 Scott AI, Townsend CA, Okada K, Kajiwara M, Cushley RJ. Biosynthesis of corrinoids. Uroporphyrinogen 3 as a precrusor of vitamin B 12 . Journal of the American Chemical Society. 94: 8269-71. PMID 5079976  0.4
1972 Scott AI, Townsend CA, Okada K, Kajiwara M, Whitman PJ. Biosynthesis of corrinoids. Concerning ithe origin of the methyl groups in vitamin B 12 . Journal of the American Chemical Society. 94: 8267-9. PMID 5079975  1
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