| Year |
Citation |
Score |
| 2024 |
Wu Z, Xia Z, Tang Z, Li J, Liu W. Mutasynthesis generates nine new pyrroindomycins. Organic & Biomolecular Chemistry. PMID 38511276 DOI: 10.1039/d4ob00239c |
0.316 |
|
| 2020 |
Li Y, Zhang J, Zheng J, Guan H, Liu W, Tan H. Co-expression of a SARP Family Activator ChlF2 and a Type II Thioesterase ChlK Led to High Production of Chlorothricin in DSM 40725. Frontiers in Bioengineering and Biotechnology. 8: 1013. PMID 32974326 DOI: 10.3389/Fbioe.2020.01013 |
0.34 |
|
| 2020 |
Du Y, Qiu Y, Meng X, Feng J, Tao J, Liu W. Correction to "A Heterotrimeric Dehydrogenase Complex Functions with 2 Distinct YcaO Proteins to Install 5 Azole Heterocycles in 35-Membered Sulfomycin Thiopeptides". Journal of the American Chemical Society. PMID 32603596 DOI: 10.1021/Jacs.0C06689 |
0.356 |
|
| 2020 |
Zhang E, Guo H, Chen D, Yang Q, Fan Y, Yin Y, Wang W, Chen D, Wang S, Liu W. Mutational biosynthesis to generate novel analogs of nosiheptide featuring a fluorinated indolic acid moiety. Organic & Biomolecular Chemistry. PMID 32412572 DOI: 10.1039/D0Ob00084A |
0.406 |
|
| 2020 |
Du Y, Qiu Y, Meng X, Feng J, Tao J, Liu W. A Heterotrimeric Dehydrogenase Complex Functions with Two Distinct YcaO Proteins to Install the Five Azole Heterocycles in the Thirty Five-Membered Thiopeptide Antibiotics Sulfomycins. Journal of the American Chemical Society. PMID 32293883 DOI: 10.1021/Jacs.0C02329 |
0.359 |
|
| 2020 |
Bai X, Guo H, Chen D, Yang Q, Tao J, Liu W. Isolation and structure determination of two new nosiheptide-type compounds provide insights into the function of the cytochrome P450 oxygenase NocV in nocathiacin biosynthesis Organic Chemistry Frontiers. 7: 584-589. DOI: 10.1039/C9Qo01328H |
0.429 |
|
| 2019 |
Xue JH, Chen GD, Hao F, Chen H, Fang Z, Chen FF, Pang B, Yang QL, Wei X, Fan QQ, Xin C, Zhao J, Deng X, Wang BA, Zhang XJ, ... ... Liu W, et al. A vitamin-C-derived DNA modification catalysed by an algal TET homologue. Nature. PMID 31043749 DOI: 10.1038/S41586-019-1160-0 |
0.338 |
|
| 2019 |
Liu J, Lin Z, Li Y, Zheng Q, Chen D, Liu W. Insights into the thioamidation of thiopeptins to enhance the understanding of the biosynthetic logic of thioamide-containing thiopeptides. Organic & Biomolecular Chemistry. PMID 30912568 DOI: 10.1039/C9Ob00402E |
0.76 |
|
| 2019 |
Jia LJ, Tang HY, Wang WQ, Yuan TL, Wei WQ, Pang B, Gong XM, Wang SF, Li YJ, Zhang D, Liu W, Tang WH. A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat. Nature Communications. 10: 922. PMID 30804501 DOI: 10.1038/S41467-019-08726-9 |
0.353 |
|
| 2019 |
Qiu Y, Du Y, Wang S, Zhou S, Guo Y, Liu W. Radical S-Adenosylmethionine Protein NosN Forms the Side Ring System of Nosiheptide by Functionalizing the Polythiazolyl Peptide S-Conjugated Indolic Moiety. Organic Letters. PMID 30785762 DOI: 10.1021/Acs.Orglett.9B00293 |
0.343 |
|
| 2019 |
Zhang D, Zhang F, Liu W. A KAS-III Heterodimer in Lipstatin Biosynthesis Nondecarboxylatively Condenses C and C Fatty Acyl-CoA Substrates by a Variable Mechanism during the Establishment of a C Aliphatic Skeleton. Journal of the American Chemical Society. PMID 30763089 DOI: 10.1021/Jacs.8B12843 |
0.367 |
|
| 2019 |
Wang J, Lin Z, Bai X, Tao J, Liu W. Optimal design of thiostrepton-derived thiopeptide antibiotics and their potential application against oral pathogens Organic Chemistry Frontiers. 6: 1194-1199. DOI: 10.1039/C9Qo00219G |
0.331 |
|
| 2019 |
Yi X, Zhao Q, Tian Z, Jia X, Cao W, Liu W, He Q. Insights into the Functionalization of the Methylsalicyclic Moiety during the Biosynthesis of Chlorothricin by Comparative Kinetic Assays of the Activities of Two KAS III‐like Acyltransferases Chinese Journal of Chemistry. 37: 821-826. DOI: 10.1002/Cjoc.201900134 |
0.372 |
|
| 2018 |
Chen D, Zhao Q, Liu W. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. Journal of Industrial Microbiology & Biotechnology. PMID 30484122 DOI: 10.1007/S10295-018-2092-7 |
0.353 |
|
| 2018 |
Awakawa T, Fujioka T, Zhang L, Hoshino S, Hu Z, Hashimoto J, Kozone I, Ikeda H, Shin-Ya K, Liu W, Abe I. Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution. Nature Communications. 9: 3534. PMID 30166552 DOI: 10.1038/S41467-018-05877-Z |
0.367 |
|
| 2018 |
Zhang D, Tang Z, Liu W. Biosynthesis of Lincosamide Antibiotics: Reactions Associated with Degradation and Detoxification Pathways Play a Constructive Role. Accounts of Chemical Research. PMID 29792672 DOI: 10.1021/Acs.Accounts.8B00135 |
0.411 |
|
| 2018 |
Liu W, Pan GH, Hao Z, Zhang L, Zhang X, Luo Y, Zhao H, Wu H, Zhang J. Highly efficient upconversion emission of Er in δ-ScZrO and broad-range temperature sensing. Physical Chemistry Chemical Physics : Pccp. PMID 29785439 DOI: 10.1039/c8cp02217h |
0.544 |
|
| 2018 |
Zheng Q, Gong Y, Guo Y, Zhao Z, Wu Z, Zhou Z, Chen D, Pan L, Liu W. Structural Insights into a Flavin-Dependent [4 + 2] Cyclase that Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis. Cell Chemical Biology. PMID 29657086 DOI: 10.1016/J.Chembiol.2018.03.007 |
0.705 |
|
| 2018 |
Wang M, Chen D, Zhao Q, Liu W. Isolation, Structure Elucidation, and Biosynthesis of a Cysteate-Containing Non-ribosomal Peptide in Streptomyces lincolnensis. The Journal of Organic Chemistry. PMID 29557172 DOI: 10.1021/Acs.Joc.8B00044 |
0.407 |
|
| 2017 |
Qiu Y, Du Y, Zhang F, Liao R, Zhou S, Peng C, Guo Y, Liu W. Thiolation Protein-Based Transfer of Indolyl to a Ribosomally Synthesized Polythiazolyl Peptide Intermediate during the Biosynthesis of the Side-Ring System of Nosiheptide. Journal of the American Chemical Society. PMID 29200275 DOI: 10.1021/Jacs.7B11367 |
0.364 |
|
| 2017 |
Li J, Li Y, Niu G, Guo H, Qiu Y, Lin Z, Liu W, Tan H. NosP-Regulated Nosiheptide Production Responds to Both Peptidyl and Small-Molecule Ligands Derived from the Precursor Peptide. Cell Chemical Biology. PMID 29198568 DOI: 10.1016/J.Chembiol.2017.10.012 |
0.387 |
|
| 2017 |
Chen M, Pang B, Du YN, Zhang YP, Liu W. Characterization of the metallo-dependent amidohydrolases responsible for "auxiliary" leucinyl removal in the biosynthesis of 2,2'-bipyridine antibiotics. Synthetic and Systems Biotechnology. 2: 137-146. PMID 29062971 DOI: 10.1016/J.Synbio.2017.07.002 |
0.377 |
|
| 2017 |
Liu W, Hao Z, Zhang L, Wu H, Zhang X, Luo Y, Pan G, Zhao H, Fu Z, Zhang J. Inhomogeneous-Broadening-Induced Intense Upconversion Luminescence in Tm(3+) and Yb(3+) Codoped Lu2O3-ZrO2 Disordered Crystals. Inorganic Chemistry. PMID 28945349 DOI: 10.1021/acs.inorgchem.7b01725 |
0.539 |
|
| 2017 |
Lin Z, Ji J, Zhou S, Zhang F, Wu J, Guo Y, Liu W. Processing 2-Methyl-L-Tryptophan through Tandem Transamination and Selective Oxygenation Initiates Indole Ring Expansion in the Biosynthesis of Thiostrepton. Journal of the American Chemical Society. PMID 28820583 DOI: 10.1021/Jacs.7B05337 |
0.357 |
|
| 2017 |
Zhong G, Zhao Q, Zhang Q, Liu W. 4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage. Nature Communications. 8: 16109. PMID 28706296 DOI: 10.1038/Ncomms16109 |
0.373 |
|
| 2017 |
Lin Z, He Q, Liu W. Bio-inspired engineering of thiopeptide antibiotics advances the expansion of molecular diversity and utility. Current Opinion in Biotechnology. 48: 210-219. PMID 28672170 DOI: 10.1016/J.Copbio.2017.06.008 |
0.382 |
|
| 2017 |
Chen M, Zhang Y, Du Y, Zhao Q, Zhang Q, Wu J, Liu W. Enzymatic competition and cooperation branch the caerulomycin biosynthetic pathway toward different 2,2'-bipyridine members. Organic & Biomolecular Chemistry. PMID 28649680 DOI: 10.1039/C7Ob01284E |
0.319 |
|
| 2017 |
Li X, Zheng Q, Yin J, Liu W, Gao S. Chemo-enzymatic synthesis of equisetin. Chemical Communications (Cambridge, England). PMID 28401214 DOI: 10.1039/C7Cc01929G |
0.746 |
|
| 2017 |
Zheng Q, Fang H, Liu W. Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics. Organic & Biomolecular Chemistry. PMID 28358161 DOI: 10.1039/C7Ob00466D |
0.76 |
|
| 2017 |
Wang S, Zheng Q, Duan P, Liu w. Progress in Synthesis of Thiopeptide Antibiotics Analogues Chinese Journal of Organic Chemistry. 37: 1653. DOI: 10.6023/Cjoc201702017 |
0.31 |
|
| 2017 |
Chen M, Liu J, Duan P, Li M, Liu W. Biosynthesis and molecular engineering of templated natural products National Science Review. 4: 553-575. DOI: 10.1093/Nsr/Nww045 |
0.358 |
|
| 2016 |
Zheng Q, Wu Z, Sun P, Chen D, Tian Z, Liu W. A linear hydroxymethyl tetramate undergoes an acetylation-elimination process for exocyclic methylene formation in the biosynthetic pathway of pyrroindomycins. Organic & Biomolecular Chemistry. PMID 27942669 DOI: 10.1039/C6Ob02567F |
0.729 |
|
| 2016 |
Zheng Q, Wang S, Duan P, Liao R, Chen D, Liu W. An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911800 DOI: 10.1073/Pnas.1612607113 |
0.755 |
|
| 2016 |
Zheng Q, Wang S, Liao R, Liu W. Precursor-directed Mutational Biosynthesis Facilitates the Functional Assignment of Two Cytochromes P450 in Thiostrepton Biosynthesis. Acs Chemical Biology. PMID 27560135 DOI: 10.1021/Acschembio.6B00419 |
0.749 |
|
| 2016 |
Pang B, Zhong G, Tang Z, Liu W. Enzymatic [4+2] Cycloadditions in the Biosynthesis of Spirotetramates and Spirotetronates. Methods in Enzymology. 575: 39-63. PMID 27417924 DOI: 10.1016/Bs.Mie.2016.02.019 |
0.388 |
|
| 2016 |
Wang M, Zhao Q, Zhang Q, Liu W. Differences in PLP-Dependent Cysteinyl Processing Lead to Diverse S-Functionalization of Lincosamide Antibiotics. Journal of the American Chemical Society. PMID 27171737 DOI: 10.1021/Jacs.6B01751 |
0.368 |
|
| 2016 |
Zheng Q, Guo Y, Yang L, Zhao Z, Wu Z, Zhang H, Liu J, Cheng X, Wu J, Yang H, Jiang H, Pan L, Liu W. Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4. Cell Chemical Biology. PMID 26877021 DOI: 10.1016/J.Chembiol.2016.01.005 |
0.736 |
|
| 2016 |
Zheng Q, Tian Z, Liu W. Recent advances in understanding the enzymatic reactions of [4+2] cycloaddition and spiroketalization. Current Opinion in Chemical Biology. 31: 95-102. PMID 26870924 DOI: 10.1016/J.Cbpa.2016.01.020 |
0.732 |
|
| 2016 |
Li Y, Li J, Tian Z, Xu Y, Zhang J, Liu W, Tan H. Coordinative Modulation of Chlorothricin Biosynthesis by Binding of the Glycosylated Intermediates and End Product to A Responsive Regulator ChlF1. The Journal of Biological Chemistry. PMID 26750095 DOI: 10.1074/Jbc.M115.695874 |
0.349 |
|
| 2016 |
Zheng Q, Liu W. Thiopeptide Antibiotics act on both Host and Microbe to Deliver Double Punch on Mycobacterial Infection Mycobacterial Diseases. 6: 1-3. DOI: 10.4172/2161-1068.1000203 |
0.707 |
|
| 2016 |
Duan P, Zheng Q, Lin Z, Wang S, Chen D, Liu W. Molecular engineering of thiostrepton: Via single "base"-based mutagenesis to generate side ring-derived variants Organic Chemistry Frontiers. 3: 1254-1258. DOI: 10.1039/C6Qo00320F |
0.734 |
|
| 2016 |
Wang S, Zheng Q, Wang J, Chen D, Yu Y, Liu W. Concurrent modifications of the C-terminus and side ring of thiostrepton and their synergistic effects with respect to improving antibacterial activities Organic Chemistry Frontiers. 3: 496-500. DOI: 10.1039/C5Qo00433K |
0.748 |
|
| 2016 |
Lin Z, Chen D, Liu W. Biosynthesis-based artificial evolution of microbial natural products Science China Chemistry. 59: 1175-1187. DOI: 10.1007/S11426-016-0062-X |
0.388 |
|
| 2015 |
Pang B, Wang M, Liu W. Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines. Natural Product Reports. PMID 26604034 DOI: 10.1039/C5Np00095E |
0.352 |
|
| 2015 |
Wang M, Zhao Q, Liu W. The versatile low-molecular-weight thiols: Beyond cell protection. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 26515639 DOI: 10.1002/Bies.201500067 |
0.345 |
|
| 2015 |
Zhang L, Mori T, Zheng Q, Awakawa T, Yan Y, Liu W, Abe I. Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 26356484 DOI: 10.1002/Anie.201506899 |
0.738 |
|
| 2015 |
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Liu W, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890 |
0.743 |
|
| 2015 |
Wang Y, Liu S, Yao P, Yu Y, Zhang Y, Lan W, Wang C, Ding J, Liu W, Cao C. Crystallographic analysis of NosA, which catalyzes terminal amide formation in the biosynthesis of nosiheptide. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1033-7. PMID 26249695 DOI: 10.1107/S2053230X15011085 |
0.331 |
|
| 2015 |
Liu S, Guo H, Zhang T, Han L, Yao P, Zhang Y, Rong N, Yu Y, Lan W, Wang C, Ding J, Wang R, Liu W, Cao C. Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis. Scientific Reports. 5: 12744. PMID 26244829 DOI: 10.1038/Srep12744 |
0.367 |
|
| 2015 |
Zheng Q, Wang Q, Wang S, Wu J, Gao Q, Liu W. Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe. Chemistry & Biology. PMID 26211364 DOI: 10.1016/J.Chembiol.2015.06.019 |
0.712 |
|
| 2015 |
Chang C, Huang R, Yan Y, Ma H, Dai Z, Zhang B, Deng Z, Liu W, Qu X. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds. Journal of the American Chemical Society. 137: 4183-90. PMID 25763681 DOI: 10.1021/Jacs.5B00728 |
0.36 |
|
| 2015 |
Tian Z, Sun P, Yan Y, Wu Z, Zheng Q, Zhou S, Zhang H, Yu F, Jia X, Chen D, Mándi A, Kurtán T, Liu W. An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nature Chemical Biology. 11: 259-65. PMID 25730548 DOI: 10.1038/Nchembio.1769 |
0.752 |
|
| 2015 |
Zhao Q, Wang M, Xu D, Zhang Q, Liu W. Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A. Nature. 518: 115-9. PMID 25607359 DOI: 10.1038/Nature14137 |
0.378 |
|
| 2015 |
Wang S, Zheng Q, Wang J, Zhao Z, Li Q, Yu Y, Wang R, Liu W. Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties Organic Chemistry Frontiers. 2: 106-109. DOI: 10.1039/C4Qo00288A |
0.722 |
|
| 2014 |
Bai T, Zhang D, Lin S, Long Q, Wang Y, Ou H, Kang Q, Deng Z, Liu W, Tao M. Operon for biosynthesis of lipstatin, the Beta-lactone inhibitor of human pancreatic lipase. Applied and Environmental Microbiology. 80: 7473-83. PMID 25239907 DOI: 10.1128/Aem.01765-14 |
0.335 |
|
| 2014 |
Sun P, Zhao Q, Zhang H, Wu J, Liu W. Effect of stereochemistry of avermectin-like 6,6-spiroketals on biological activities and endogenous biotransformations in streptomyces avermectinius Chembiochem. 15: 660-664. PMID 24573905 DOI: 10.1002/Cbic.201300616 |
0.325 |
|
| 2014 |
Guo H, Wang J, Li Y, Yu Y, Zheng Q, Wu J, Liu W. Insight into bicyclic thiopeptide biosynthesis benefited from development of a uniform approach for molecular engineering and production improvement Chemical Science. 5: 240-246. DOI: 10.1039/C3Sc52015C |
0.749 |
|
| 2014 |
Zheng Q, Wang S, Liu W. Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis Tetrahedron. 70: 7686-7690. DOI: 10.1016/J.Tet.2014.06.076 |
0.739 |
|
| 2013 |
Yan Y, Chen J, Zhang L, Zheng Q, Han Y, Zhang H, Zhang D, Awakawa T, Abe I, Liu W. Multiplexing of combinatorial chemistry in antimycin biosynthesis: Expansion of molecular diversity and utility Angewandte Chemie - International Edition. 52: 12308-12312. PMID 24123503 DOI: 10.1002/Anie.201305569 |
0.723 |
|
| 2013 |
Wang S, Zhou S, Liu W. Opportunities and challenges from current investigations into the biosynthetic logic of nosiheptide-represented thiopeptide antibiotics Current Opinion in Chemical Biology. 17: 626-634. PMID 23838388 DOI: 10.1016/J.Cbpa.2013.06.021 |
0.382 |
|
| 2013 |
Chen D, Zhang L, Pang B, Chen J, Xu Z, Abe I, Liu W. FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation. Journal of Bacteriology. 195: 1931-9. PMID 23435975 DOI: 10.1128/Jb.00033-13 |
0.382 |
|
| 2013 |
Shao L, Chen J, Wang C, Li JA, Tang Y, Chen D, Liu W. Characterization of a key aminoglycoside phosphotransferase in gentamicin biosynthesis. Bioorganic & Medicinal Chemistry Letters. 23: 1438-41. PMID 23339967 DOI: 10.1016/J.Bmcl.2012.12.064 |
0.37 |
|
| 2013 |
Sun P, Zhao Q, Yu F, Zhang H, Wu Z, Wang Y, Zhang Q, Liu W. Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of avec Journal of the American Chemical Society. 135: 1540-1548. PMID 23294008 DOI: 10.1021/Ja311339U |
0.428 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Liu W, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F |
0.515 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Liu W, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A |
0.505 |
|
| 2013 |
Zhang Q, Liu W. Biosynthesis of thiopeptide antibiotics and their pathway engineering Natural Product Reports. 30: 218-226. DOI: 10.1039/C2Np20107K |
0.354 |
|
| 2013 |
Zhang Q, Pang B, Ding W, Liu W. Aromatic polyketides produced by bacterial iterative type i polyketide synthases Acs Catalysis. 3: 1439-1447. DOI: 10.1021/Cs400211X |
0.402 |
|
| 2012 |
He HY, Pan HX, Wu LF, Zhang BB, Chai HB, Liu W, Tang GL. Quartromicin biosynthesis: Two alternative polyketide chains produced by one polyketide synthase assembly line Chemistry and Biology. 19: 1313-1323. PMID 23102224 DOI: 10.1016/J.Chembiol.2012.07.024 |
0.412 |
|
| 2012 |
Wu Q, Wu Z, Qu X, Liu W. Insights into pyrroindomycin biosynthesis reveal a uniform paradigm for tetramate/tetronate formation Journal of the American Chemical Society. 134: 17342-17345. PMID 23062149 DOI: 10.1021/Ja304829G |
0.373 |
|
| 2012 |
Li J, Qu X, He X, Duan L, Wu G, Bi D, Deng Z, Liu W, Ou HY. ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences Plos One. 7. PMID 23029291 DOI: 10.1371/Journal.Pone.0045878 |
0.408 |
|
| 2012 |
Yan Y, Zhang L, Ito T, Qu X, Asakawa Y, Awakawa T, Abe I, Liu W. Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production Organic Letters. 14: 4142-4145. PMID 22861048 DOI: 10.1021/Ol301785X |
0.415 |
|
| 2012 |
Qu X, Pang B, Zhang Z, Chen M, Wu Z, Zhao Q, Zhang Q, Wang Y, Liu Y, Liu W. Caerulomycins and collismycins share a common paradigm for 2,2'-bipyridine biosynthesis via an unusual hybrid polyketide-peptide assembly Logic. Journal of the American Chemical Society. 134: 9038-41. PMID 22594451 DOI: 10.1021/Ja3016457 |
0.432 |
|
| 2012 |
Chen D, Zhang Q, Zhang Q, Cen P, Xu Z, Liu W. Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems. Applied and Environmental Microbiology. 78: 5093-103. PMID 22582065 DOI: 10.1128/Aem.00450-12 |
0.402 |
|
| 2012 |
Duan L, Wang S, Liao R, Liu W. Insights into quinaldic acid moiety formation in thiostrepton biosynthesis facilitating fluorinated thiopeptide generation Chemistry and Biology. 19: 443-448. PMID 22520750 DOI: 10.1016/J.Chembiol.2012.02.008 |
0.366 |
|
| 2012 |
Zhang Q, Van Der Donk WA, Liu W. Radical-mediated enzymatic methylation: A tale of two SAMS Accounts of Chemical Research. 45: 555-564. PMID 22097883 DOI: 10.1021/Ar200202C |
0.336 |
|
| 2011 |
Qu X, Lei C, Liu W. Transcriptome mining of active biosynthetic pathways and their associated products in streptomyces flaveolus Angewandte Chemie - International Edition. 50: 9651-9654. PMID 21948600 DOI: 10.1002/Anie.201103085 |
0.314 |
|
| 2011 |
Wu J, Zhang Q, Deng W, Qian J, Zhang S, Liu W. Toward improvement of erythromycin a production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination Applied and Environmental Microbiology. 77: 7508-7516. PMID 21841022 DOI: 10.1128/Aem.06034-11 |
0.34 |
|
| 2011 |
Zhang Q, Chen D, Lin J, Liao R, Tong W, Xu Z, Liu W. Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: a [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme. The Journal of Biological Chemistry. 286: 21287-94. PMID 21454624 DOI: 10.1074/Jbc.M111.224832 |
0.331 |
|
| 2011 |
Qu X, Jiang N, Xu F, Shao L, Tang G, Wilkinson B, Liu W. Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor. Molecular Biosystems. 7: 852-61. PMID 21416665 DOI: 10.1039/C0Mb00234H |
0.442 |
|
| 2011 |
Liao R, Liu W. Thiostrepton maturation involving a deesterification-amidation way to process the C-terminally methylated peptide backbone Journal of the American Chemical Society. 133: 2852-2855. PMID 21323347 DOI: 10.1021/Ja1111173 |
0.358 |
|
| 2011 |
Zhang Q, Li Y, Chen D, Yu Y, Duan L, Shen B, Liu W. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology. 7: 154-60. PMID 21240261 DOI: 10.1038/Nchembio.512 |
0.538 |
|
| 2010 |
Yu Y, Guo H, Zhang Q, Duan L, Ding Y, Liao R, Lei C, Shen B, Liu W. NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide. Journal of the American Chemical Society. 132: 16324-6. PMID 21047073 DOI: 10.1021/Ja106571G |
0.538 |
|
| 2010 |
Ding W, Lei C, He Q, Zhang Q, Bi Y, Liu W. Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation Chemistry and Biology. 17: 495-503. PMID 20534347 DOI: 10.1016/J.Chembiol.2010.04.009 |
0.371 |
|
| 2010 |
Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W. Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B Molecular Biosystems. 6: 1071-1081. PMID 20485749 DOI: 10.1039/B926358F |
0.386 |
|
| 2010 |
Ding Y, Yu Y, Pan H, Guo H, Li Y, Liu W. Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. Molecular Biosystems. 6: 1180-5. PMID 20473441 DOI: 10.1039/C005121G |
0.418 |
|
| 2010 |
Wang J, Yu Y, Tang K, Liu W, He X, Huang X, Deng Z. Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22 Applied and Environmental Microbiology. 76: 2335-2344. PMID 20154110 DOI: 10.1128/Aem.01790-09 |
0.431 |
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| 2009 |
Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W. Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. Acs Chemical Biology. 4: 855-64. PMID 19678698 DOI: 10.1021/Cb900133X |
0.614 |
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| 2009 |
Fu CY, Tang MC, Peng C, Li L, He YL, Liu W, Tang GL. Biosynthesis of 3-hydroxy-5-methyl-o-methyltyrosine in the saframycin/ safracin biosynthetic pathway. Journal of Microbiology and Biotechnology. 19: 439-46. PMID 19494690 DOI: 10.4014/Jmb.0808.484 |
0.418 |
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| 2009 |
Liao R, Duan L, Lei C, Pan H, Ding Y, Zhang Q, Chen D, Shen B, Yu Y, Liu W. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chemistry & Biology. 16: 141-7. PMID 19246004 DOI: 10.1016/J.Chembiol.2009.01.007 |
0.598 |
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| 2008 |
Galm U, Wang L, Wendt-Pienkowski E, Yang R, Liu W, Tao M, Coughlin JM, Shen B. In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway. The Journal of Biological Chemistry. 283: 28236-45. PMID 18697737 DOI: 10.1074/Jbc.M804971200 |
0.779 |
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| 2008 |
Zhao Q, He Q, Ding W, Tang M, Kang Q, Yu Y, Deng W, Zhang Q, Fang J, Tang G, Liu W. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chemistry & Biology. 15: 693-705. PMID 18635006 DOI: 10.1016/J.Chembiol.2008.05.021 |
0.421 |
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| 2008 |
Fang J, Zhang Y, Huang L, Jia X, Zhang Q, Zhang X, Tang G, Liu W. Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics. Journal of Bacteriology. 190: 6014-25. PMID 18586939 DOI: 10.1128/Jb.00533-08 |
0.459 |
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| 2008 |
Zhang J, Van Lanen SG, Ju J, Liu W, Dorrestein PC, Li W, Kelleher NL, Shen B. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 1460-5. PMID 18223152 DOI: 10.1073/Pnas.0711625105 |
0.572 |
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| 2008 |
Chen Y, Deng W, Wu J, Qian J, Chu J, Zhuang Y, Zhang S, Liu W. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. Applied and Environmental Microbiology. 74: 1820-8. PMID 18223111 DOI: 10.1128/Aem.02770-07 |
0.301 |
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| 2008 |
Li L, Deng W, Song J, Ding W, Zhao QF, Peng C, Song WW, Tang GL, Liu W. Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. Journal of Bacteriology. 190: 251-63. PMID 17981978 DOI: 10.1128/Jb.00826-07 |
0.45 |
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| 2007 |
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B. Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. Journal of the American Chemical Society. 129: 13082-94. PMID 17918933 DOI: 10.1021/Ja073275O |
0.583 |
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| 2007 |
Kennedy DR, Gawron LS, Ju J, Liu W, Shen B, Beerman TA. Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks. Cancer Research. 67: 773-81. PMID 17234789 DOI: 10.1158/0008-5472.Can-06-2893 |
0.484 |
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| 2006 |
Jia XY, Tian ZH, Shao L, Qu XD, Zhao QF, Tang J, Tang GL, Liu W. Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis. Chemistry & Biology. 13: 575-85. PMID 16793515 DOI: 10.1016/J.Chembiol.2006.03.008 |
0.379 |
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| 2006 |
Shao L, Qu XD, Jia XY, Zhao QF, Tian ZH, Wang M, Tang GL, Liu W. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochemical and Biophysical Research Communications. 345: 133-9. PMID 16677607 DOI: 10.1016/J.Bbrc.2006.04.069 |
0.413 |
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| 2005 |
Van Lanen SG, Dorrestein PC, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B. Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. Journal of the American Chemical Society. 127: 11594-5. PMID 16104723 DOI: 10.1021/Ja052871K |
0.768 |
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| 2005 |
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B. The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. Chemistry & Biology. 12: 293-302. PMID 15797213 DOI: 10.1016/J.Chembiol.2004.12.013 |
0.784 |
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| 2004 |
Murrell JM, Liu W, Shen B. Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production. Journal of Natural Products. 67: 206-13. PMID 14987060 DOI: 10.1021/Np0340403 |
0.775 |
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| 2003 |
Shen B, Liu W, Nonaka K. Enediyne natural products: biosynthesis and prospect towards engineering novel antitumor agents. Current Medicinal Chemistry. 10: 2317-25. PMID 14529344 DOI: 10.2174/0929867033456701 |
0.579 |
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| 2003 |
Liu W, Ahlert J, Gao Q, Wendt-Pienkowski E, Shen B, Thorson JS. Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model. Proceedings of the National Academy of Sciences of the United States of America. 100: 11959-63. PMID 14528002 DOI: 10.1073/Pnas.2034291100 |
0.663 |
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| 2003 |
Christenson SD, Liu W, Toney MD, Shen B. A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Journal of the American Chemical Society. 125: 6062-3. PMID 12785829 DOI: 10.1021/Ja034609M |
0.793 |
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| 2003 |
Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology. 21: 187-90. PMID 12536216 DOI: 10.1038/Nbt784 |
0.685 |
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| 2002 |
Liu W, Christenson SD, Standage S, Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science (New York, N.Y.). 297: 1170-3. PMID 12183628 DOI: 10.1126/Science.1072110 |
0.791 |
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| 2000 |
Liu W, Shen B. Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein Antimicrobial Agents and Chemotherapy. 44: 382-392. PMID 10639366 DOI: 10.1128/Aac.44.2.382-392.2000 |
0.582 |
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| 1999 |
Thorson JS, Shen B, Whitwam RE, Liu W, Li Y, Ahlert J. Enediyne biosynthesis and self-resistance: A progress report Bioorganic Chemistry. 27: 172-188. DOI: 10.1006/Bioo.1998.1122 |
0.666 |
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