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Chaitan Khosla - Publications

Affiliations: 
Chemistry Stanford University, Palo Alto, CA 
Area:
Bioorganic and Biophysical Chemistry
Website:
https://chemistry.stanford.edu/people/chaitan-khosla

242 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C. Discovery and characterization of a thioesterase-specific monoclonal antibody that recognizes the 6-deoxyerythronolide B synthase. Biochemistry. PMID 30289692 DOI: 10.1021/acs.biochem.8b00886  0.44
2018 Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C. Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society. PMID 29762030 DOI: 10.1021/jacs.8b02100  1
2018 Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, ... ... Khosla C, et al. HEx: A heterologous expression platform for the discovery of fungal natural products. Science Advances. 4: eaar5459. PMID 29651464 DOI: 10.1126/sciadv.aar5459  1
2018 Yi MC, Melkonian AV, Ousey JA, Khosla C. Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2. The Journal of Biological Chemistry. PMID 29305423 DOI: 10.1074/jbc.RA117.001382  0.4
2017 Xiao X, Sankaranarayanan K, Khosla C. Biosynthesis and structure-activity relationships of the lipid a family of glycolipids. Current Opinion in Chemical Biology. 40: 127-137. PMID 28942130 DOI: 10.1016/j.cbpa.2017.07.008  0.48
2017 Mathews II, Allison K, Robbins T, Lyubimov A, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis SM, Cohen AE. Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase is revealed at an X-Ray Free Electron Laser using a Room-Temperature Sample Delivery Method for Serial Crystallography. Biochemistry. PMID 28832129 DOI: 10.1021/acs.biochem.7b00711  0.44
2017 Xie X, Garg A, Khosla C, Cane DE. Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. Journal of the American Chemical Society. PMID 28682630 DOI: 10.1021/jacs.7b05502  1
2017 Xie X, Khosla C, Cane DE. Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. Journal of the American Chemical Society. PMID 28430424 DOI: 10.1021/jacs.7b02911  1
2017 Vandova GA, O'Brien RV, Lowry B, Robbins TF, Fischer CR, Davis RW, Khosla C, Harvey CJ, Hillenmeyer ME. Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli. The Journal of Antibiotics. PMID 28400575 DOI: 10.1038/ja.2017.38  0.44
2017 Xie X, Garg A, Khosla C, Cane DE. Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. Journal of the American Chemical Society. PMID 28157306 DOI: 10.1021/jacs.7b00278  1
2016 Robbins T, Kapilivsky J, Cane DE, Khosla C. Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase. Biochemistry. PMID 27441852 DOI: 10.1021/acs.biochem.6b00639  1
2016 Kuo J, Lynch SR, Liu CW, Xiao X, Khosla C. Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis. Acs Chemical Biology. PMID 27384917 DOI: 10.1021/acschembio.6b00489  1
2016 Robbins T, Liu YC, Cane DE, Khosla C. Structure and mechanism of assembly line polyketide synthases. Current Opinion in Structural Biology. 41: 10-18. PMID 27266330 DOI: 10.1016/j.sbi.2016.05.009  1
2016 Klaus M, Ostrowski MP, Austerjost J, Robbins T, Lowry B, Cane DE, Khosla C. Protein Protein Interactions, not Substrate Recognition, Dominates the Turnover of Chimeric Assembly Line Polyketide Synthases. The Journal of Biological Chemistry. PMID 27246853 DOI: 10.1074/jbc.M116.730531  1
2016 Ostrowski MP, Cane DE, Khosla C. Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases. The Journal of Antibiotics. PMID 27118242 DOI: 10.1038/ja.2016.41  1
2016 Yi MC, Khosla C. Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment. Annual Review of Chemical and Biomolecular Engineering. PMID 27023663 DOI: 10.1146/annurev-chembioeng-080615-033553  1
2016 Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nature Chemical Biology. PMID 27018887 DOI: 10.1038/nchembio.2050  1
2016 Lowry B, Li X, Robbins T, Cane DE, Khosla C. A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases. Acs Central Science. 2: 14-20. PMID 26878060 DOI: 10.1021/acscentsci.5b00321  1
2016 Xie X, Garg A, Keatinge-Clay AT, Khosla C, Cane DE. The Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. Biochemistry. PMID 26863427 DOI: 10.1021/acs.biochem.6b00024  1
2015 Lowry B, Walsh CT, Khosla C. In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 26: 1008-1025. PMID 26207083 DOI: 10.1055/s-0034-1380264  0.76
2015 Khosla C. Quo vadis, enzymology? Nature Chemical Biology. 11: 438-41. PMID 26083060 DOI: 10.1038/nchembio.1844  1
2015 Plugis NM, Khosla C. Therapeutic approaches for celiac disease. Best Practice & Research. Clinical Gastroenterology. 29: 503-521. PMID 26060114 DOI: 10.1016/j.bpg.2015.04.005  1
2015 Yi MC, Palanski BA, Quintero SA, Plugis NM, Khosla C. An unprecedented dual antagonist and agonist of human Transglutaminase 2. Bioorganic & Medicinal Chemistry Letters. PMID 26004580 DOI: 10.1016/j.bmcl.2015.05.006  1
2015 Lowry B, Walsh CT, Khosla C. In Vitro Reconstitution of Metabolic Pathways: Insights into Nature’s Chemical Logic Synlett. DOI: 10.1055/s-0034-1380264  1
2015 Lebwohl B, Murray JA, Verdú EF, Crowe SE, Dennis M, Fasano A, Green PHR, Guandalini S, Khosla C. Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board American Journal of Gastroenterology. DOI: 10.1038/ajg.2015.219  1
2014 Klöck C, Herrera Z, Albertelli M, Khosla C. Discovery of potent and specific dihydroisoxazole inhibitors of human transglutaminase 2. Journal of Medicinal Chemistry. 57: 9042-64. PMID 25333388 DOI: 10.1021/jm501145a  1
2014 Penumatsa KC, Toksoz D, Warburton RR, Hilmer AJ, Liu T, Khosla C, Comhair SA, Fanburg BL. Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 307: L576-85. PMID 25128524 DOI: 10.1152/ajplung.00162.2014  1
2014 Garg A, Xie X, Keatinge-Clay A, Khosla C, Cane DE. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange. Journal of the American Chemical Society. 136: 10190-3. PMID 25004372 DOI: 10.1021/ja5056998  1
2014 Le BV, Klöck C, Schatz A, Nguyen JB, Kakani EG, Catteruccia F, Khosla C, Baxter RH. Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3. Malaria Journal. 13: 210. PMID 24888439 DOI: 10.1186/1475-2875-13-210  1
2014 Stevenson HP, Makhov AM, Calero M, Edwards AL, Zeldin OB, Mathews II, Lin G, Barnes CO, Santamaria H, Ross TM, Soltis SM, Khosla C, Nagarajan V, Conway JF, Cohen AE, et al. Use of transmission electron microscopy to identify nanocrystals of challenging protein targets. Proceedings of the National Academy of Sciences of the United States of America. 111: 8470-5. PMID 24872454 DOI: 10.1073/pnas.1400240111  1
2014 Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C. Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases. Biochemistry. 53: 3796-806. PMID 24871074 DOI: 10.1021/bi5004316  1
2014 Khosla C, Herschlag D, Cane DE, Walsh CT. Assembly line polyketide synthases: mechanistic insights and unsolved problems. Biochemistry. 53: 2875-83. PMID 24779441 DOI: 10.1021/bi500290t  1
2014 Alvarez-Sieiro P, Martin MC, Redruello B, Del Rio B, Ladero V, Palanski BA, Khosla C, Fernandez M, Alvarez MA. Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase. Applied Microbiology and Biotechnology. 98: 6689-700. PMID 24752841 DOI: 10.1007/s00253-014-5730-7  1
2014 Edwards AL, Matsui T, Weiss TM, Khosla C. Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase. Journal of Molecular Biology. 426: 2229-45. PMID 24704088 DOI: 10.1016/j.jmb.2014.03.015  1
2014 Kuo J, Khosla C. The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of Synechococcus sp. PCC 7002. Metabolic Engineering. 22: 53-9. PMID 24395007 DOI: 10.1016/j.ymben.2013.12.008  1
2014 O'Brien RV, Davis RW, Khosla C, Hillenmeyer ME. Computational identification and analysis of orphan assembly-line polyketide synthases. The Journal of Antibiotics. 67: 89-97. PMID 24301183 DOI: 10.1038/ja.2013.125  1
2014 DiRaimondo TR, Klöck C, Warburton R, Herrera Z, Penumatsa K, Toksoz D, Hill N, Khosla C, Fanburg B. Elevated transglutaminase 2 activity is associated with hypoxia-induced experimental pulmonary hypertension in mice. Acs Chemical Biology. 9: 266-75. PMID 24152195 DOI: 10.1021/cb4006408  1
2014 Khosla C. The Convergence of Chemistry & Human Biology Daedalus. 143: 43-48. DOI: 10.1162/DAED_a_00304  1
2014 May AE, Khosla C. Macrolides and Antifungals via Biotransformation Natural Products in Medicinal Chemistry. 365-402. DOI: 10.1002/9783527676545.ch11  1
2013 Garg A, Khosla C, Cane DE. Coupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange. Journal of the American Chemical Society. 135: 16324-7. PMID 24161343 DOI: 10.1021/ja408944s  1
2013 Lowry B, Robbins T, Weng CH, O'Brien RV, Cane DE, Khosla C. In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 135: 16809-12. PMID 24161212 DOI: 10.1021/ja409048k  1
2013 Xiao X, Yu X, Khosla C. Metabolic flux between unsaturated and saturated fatty acids is controlled by the FabA:FabB ratio in the fully reconstituted fatty acid biosynthetic pathway of Escherichia coli. Biochemistry. 52: 8304-12. PMID 24147979 DOI: 10.1021/bi401116n  1
2013 Chen JK, Du Bois J, Glenn J, Herschlag D, Khosla C. The Stanford Institute for Chemical Biology. Acs Chemical Biology. 8: 1860-1. PMID 24053754 DOI: 10.1021/cb400641u  1
2013 Walker MC, Thuronyi BW, Charkoudian LK, Lowry B, Khosla C, Chang MC. Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science (New York, N.Y.). 341: 1089-94. PMID 24009388 DOI: 10.1126/science.1242345  1
2013 Han A, Newell EW, Glanville J, Fernandez-Becker N, Khosla C, Chien YH, Davis MM. Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease. Proceedings of the National Academy of Sciences of the United States of America. 110: 13073-8. PMID 23878218 DOI: 10.1073/pnas.1311861110  1
2013 Morón B, Verma AK, Das P, Taavela J, Dafik L, Diraimondo TR, Albertelli MA, Kraemer T, Mäki M, Khosla C, Rogler G, Makharia GK. CYP3A4-catalyzed simvastatin metabolism as a non-invasive marker of small intestinal health in celiac disease. The American Journal of Gastroenterology. 108: 1344-51. PMID 23732466 DOI: 10.1038/ajg.2013.151  1
2013 Walsh CT, O'Brien RV, Khosla C. Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angewandte Chemie (International Ed. in English). 52: 7098-124. PMID 23729217 DOI: 10.1002/anie.201208344  1
2013 Dunn BJ, Khosla C. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. Journal of the Royal Society, Interface / the Royal Society. 10: 20130297. PMID 23720536 DOI: 10.1098/rsif.2013.0297  1
2013 You YO, Khosla C, Cane DE. Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases. Journal of the American Chemical Society. 135: 7406-9. PMID 23659177 DOI: 10.1021/ja4014776  1
2013 Xu H, Feely SL, Wang X, Liu DX, Borda JT, Dufour J, Li W, Aye PP, Doxiadis GG, Khosla C, Veazey RS, Sestak K. Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease. Clinical Immunology (Orlando, Fla.). 147: 40-9. PMID 23518597 DOI: 10.1016/j.clim.2013.02.012  1
2013 Dunn BJ, Cane DE, Khosla C. Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase. Biochemistry. 52: 1839-41. PMID 23452124 DOI: 10.1021/bi400185v  1
2013 Fitzgerald JT, Charkoudian LK, Watts KR, Khosla C. Analysis and refactoring of the A-74528 biosynthetic pathway. Journal of the American Chemical Society. 135: 3752-5. PMID 23442197 DOI: 10.1021/ja311579s  1
2013 DiRaimondo TR, Plugis NM, Jin X, Khosla C. Selective inhibition of extracellular thioredoxin by asymmetric disulfides. Journal of Medicinal Chemistry. 56: 1301-10. PMID 23327656 DOI: 10.1021/jm301775s  1
2013 May AE, Khosla C. Discovery and mechanism of Type III secretion system inhibitors Israel Journal of Chemistry. 53: 577-587. DOI: 10.1002/ijch.201300025  1
2013 Lowry B, Khosla C. Analysis and engineering of modular polyketide synthase systems Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 337.  1
2012 Holmes TC, May AE, Zaleta-Rivera K, Ruby JG, Skewes-Cox P, Fischbach MA, DeRisi JL, Iwatsuki M, ÅŒmura S, Khosla C. Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor. Journal of the American Chemical Society. 134: 17797-806. PMID 23030602 DOI: 10.1021/ja308622d  1
2012 Klöck C, Khosla C. Regulation of the activities of the mammalian transglutaminase family of enzymes. Protein Science : a Publication of the Protein Society. 21: 1781-91. PMID 23011841 DOI: 10.1002/pro.2162  1
2012 Harvey CJ, Puglisi JD, Pande VS, Cane DE, Khosla C. Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. Journal of the American Chemical Society. 134: 12259-65. PMID 22741553 DOI: 10.1021/ja304682q  1
2012 Yuzawa S, Kapur S, Cane DE, Khosla C. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. Biochemistry. 51: 3708-10. PMID 22509729 DOI: 10.1021/bi300399u  1
2012 Klöck C, Diraimondo TR, Khosla C. Role of transglutaminase 2 in celiac disease pathogenesis. Seminars in Immunopathology. 34: 513-22. PMID 22437759 DOI: 10.1007/s00281-012-0305-0  1
2012 Wang J, Jin X, Liu J, Khosla C, Xia J. Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease. Chemistry, An Asian Journal. 7: 992-9. PMID 22411856 DOI: 10.1002/asia.201101041  1
2012 Kapur S, Lowry B, Yuzawa S, Kenthirapalan S, Chen AY, Cane DE, Khosla C. Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation. Proceedings of the National Academy of Sciences of the United States of America. 109: 4110-5. PMID 22371562 DOI: 10.1073/pnas.1118734109  1
2012 Wong FT, Khosla C. Combinatorial biosynthesis of polyketides--a perspective. Current Opinion in Chemical Biology. 16: 117-23. PMID 22342766 DOI: 10.1016/j.cbpa.2012.01.018  1
2012 Dafik L, Albertelli M, Stamnaes J, Sollid LM, Khosla C. Activation and inhibition of transglutaminase 2 in mice. Plos One. 7: e30642. PMID 22319575 DOI: 10.1371/journal.pone.0030642  1
2012 Diraimondo TR, Klöck C, Khosla C. Interferon-γ activates transglutaminase 2 via a phosphatidylinositol-3-kinase-dependent pathway: implications for celiac sprue therapy. The Journal of Pharmacology and Experimental Therapeutics. 341: 104-14. PMID 22228808 DOI: 10.1124/jpet.111.187385  1
2012 Bethune MT, Khosla C. Oral enzyme therapy for celiac sprue. Methods in Enzymology. 502: 241-71. PMID 22208988 DOI: 10.1016/B978-0-12-416039-2.00013-6  1
2012 Charkoudian LK, Farrell BP, Khosla C. Natural product inhibitors of glucose-6-phosphate translocase Medchemcomm. 3: 926-931. DOI: 10.1039/c2md20008b  1
2012 Harvey CJB, Khosla C. Precursor-Directed Biosynthesis of Polyketide and Nonribosomal Peptide Natural Products Modern Tools For the Synthesis of Complex Bioactive Molecules. 485-512. DOI: 10.1002/9781118342886.ch14  1
2012 Yu X, Khosla C. Engineering escherichia coli for biotransformation of biomass into fatty acid derived fuels Current Chemical Biology. 6: 7-13.  1
2011 Yu X, Liu T, Zhu F, Khosla C. In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 18643-8. PMID 22042840 DOI: 10.1073/pnas.1110852108  1
2011 Fitzgerald JT, Henrich PP, O'Brien C, Krause M, Ekland EH, Mattheis C, Sá JM, Fidock D, Khosla C. In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei. The Journal of Antibiotics. 64: 799-801. PMID 22008701 DOI: 10.1038/ja.2011.94  1
2011 Fitzgerald JT, Ridley CP, Khosla C. Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host. The Journal of Antibiotics. 64: 759-62. PMID 21934692 DOI: 10.1038/ja.2011.86  1
2011 Jin X, Stamnaes J, Klöck C, DiRaimondo TR, Sollid LM, Khosla C. Activation of extracellular transglutaminase 2 by thioredoxin. The Journal of Biological Chemistry. 286: 37866-73. PMID 21908620 DOI: 10.1074/jbc.M111.287490  1
2011 Szu PH, Govindarajan S, Meehan MJ, Das A, Nguyen DD, Dorrestein PC, Minshull J, Khosla C. Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chemistry & Biology. 18: 1021-31. PMID 21867917 DOI: 10.1016/j.chembiol.2011.07.015  1
2011 Javidpour P, Das A, Khosla C, Tsai SC. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 50: 7426-39. PMID 21776967 DOI: 10.1021/bi2006866  1
2011 Wong FT, Jin X, Mathews II, Cane DE, Khosla C. Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. Biochemistry. 50: 6539-48. PMID 21707057 DOI: 10.1021/bi200632j  1
2011 Charkoudian LK, Liu CW, Capone S, Kapur S, Cane DE, Togni A, Seebach D, Khosla C. Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase. Protein Science : a Publication of the Protein Society. 20: 1244-55. PMID 21563224 DOI: 10.1002/pro.652  1
2011 Lee Y, Choi JY, Fu H, Harvey C, Ravindran S, Roush WR, Boothroyd JC, Khosla C. Chemistry and biology of macrolide antiparasitic agents. Journal of Medicinal Chemistry. 54: 2792-804. PMID 21428405 DOI: 10.1021/jm101593u  1
2011 Sollid LM, Khosla C. Novel therapies for coeliac disease. Journal of Internal Medicine. 269: 604-13. PMID 21401739 DOI: 10.1111/j.1365-2796.2011.02376.x  1
2011 Dafik L, Khosla C. Dihydroisoxazole analogs for labeling and visualization of catalytically active transglutaminase 2. Chemistry & Biology. 18: 58-66. PMID 21276939 DOI: 10.1016/j.chembiol.2010.11.004  1
2011 Klöck C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin JH. Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorganic & Medicinal Chemistry Letters. 21: 2692-6. PMID 21215619 DOI: 10.1016/j.bmcl.2010.12.037  1
2011 Lee HY, Harvey CJ, Cane DE, Khosla C. Improved precursor-directed biosynthesis in E. coli via directed evolution. The Journal of Antibiotics. 64: 59-64. PMID 21081955 DOI: 10.1038/ja.2010.129  1
2011 Yuan L, Holmes TC, Watts RE, Khosla C, Broekelmann TJ, Mecham R, Zheng H, Izaguirre EW, Rich KM. Novel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomas. Journal of Neuro-Oncology. 103: 207-19. PMID 20824305 DOI: 10.1007/s11060-010-0379-2  1
2011 Chen AY, Khosla C. Protein Engineering of Modular Polyketide Synthases Protein Engineering Handbook, Volume 1 & Volume 2. 2: 797-827. DOI: 10.1002/9783527634026.ch32  1
2011 Khosla C. Better than Sliced Bread Letters to a Young Chemist. 155-164. DOI: 10.1002/9781118007099.ch10  1
2010 Kapur S, Chen AY, Cane DE, Khosla C. Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 22066-71. PMID 21127271 DOI: 10.1073/pnas.1014081107  1
2010 Charkoudian LK, Fitzgerald JT, Khosla C, Champlin A. In living color: bacterial pigments as an untapped resource in the classroom and beyond. Plos Biology. 8. PMID 20957190 DOI: 10.1371/journal.pbio.1000510  1
2010 Liu T, Khosla C. Chemistry. A balancing act for Taxol precursor pathways in E. coli. Science (New York, N.Y.). 330: 44-5. PMID 20929799 DOI: 10.1126/science.1195014  1
2010 Valenzano CR, You YO, Garg A, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. Journal of the American Chemical Society. 132: 14697-9. PMID 20925342 DOI: 10.1021/ja107344h  1
2010 Liu T, Khosla C. Genetic engineering of Escherichia coli for biofuel production. Annual Review of Genetics. 44: 53-69. PMID 20822440 DOI: 10.1146/annurev-genet-102209-163440  1
2010 Zaleta-Rivera K, Charkoudian LK, Ridley CP, Khosla C. Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis. Journal of the American Chemical Society. 132: 9122-8. PMID 20550125 DOI: 10.1021/ja102519v  1
2010 Stamnaes J, Pinkas DM, Fleckenstein B, Khosla C, Sollid LM. Redox regulation of transglutaminase 2 activity. The Journal of Biological Chemistry. 285: 25402-9. PMID 20547769 DOI: 10.1074/jbc.M109.097162  1
2010 Das A, Szu PH, Fitzgerald JT, Khosla C. Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis. Journal of the American Chemical Society. 132: 8831-3. PMID 20540492 DOI: 10.1021/ja102517q  1
2010 Khosla C. Thematic minireview series on antibacterial natural products: new tricks for old dogs. The Journal of Biological Chemistry. 285: 27499. PMID 20522550 DOI: 10.1074/jbc.R110.150417  1
2010 Tahanian E, Lord-Dufour S, Das A, Khosla C, Roy R, Annabi B. Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog. Chemical Biology & Drug Design. 75: 481-8. PMID 20486934 DOI: 10.1111/j.1747-0285.2010.00961.x  1
2010 Mazumdar K, Alvarez X, Borda JT, Dufour J, Martin E, Bethune MT, Khosla C, Sestak K. Visualization of transepithelial passage of the immunogenic 33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques. Plos One. 5: e10228. PMID 20419103 DOI: 10.1371/journal.pone.0010228  1
2010 Matic I, Sacchi A, Rinaldi A, Melino G, Khosla C, Falasca L, Piacentini M. Characterization of transglutaminase type II role in dendritic cell differentiation and function. Journal of Leukocyte Biology. 88: 181-8. PMID 20371597 DOI: 10.1189/jlb.1009691  1
2010 Liu T, Vora H, Khosla C. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metabolic Engineering. 12: 378-86. PMID 20184964 DOI: 10.1016/j.ymben.2010.02.003  1
2010 Sealey-Voyksner JA, Khosla C, Voyksner RD, Jorgenson JW. Novel aspects of quantitation of immunogenic wheat gluten peptides by liquid chromatography-mass spectrometry/mass spectrometry. Journal of Chromatography. A. 1217: 4167-83. PMID 20181349 DOI: 10.1016/j.chroma.2010.01.067  1
2010 Wong FT, Chen AY, Cane DE, Khosla C. Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases. Biochemistry. 49: 95-102. PMID 19921859 DOI: 10.1021/bi901826g  1
2009 Das A, Khosla C. In vivo and in vitro analysis of the hedamycin polyketide synthase. Chemistry & Biology. 16: 1197-207. PMID 19942143 DOI: 10.1016/j.chembiol.2009.11.005  1
2009 Valenzano CR, Lawson RJ, Chen AY, Khosla C, Cane DE. The biochemical basis for stereochemical control in polyketide biosynthesis. Journal of the American Chemical Society. 131: 18501-11. PMID 19928853 DOI: 10.1021/ja908296m  1
2009 Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C. Noninflammatory gluten peptide analogs as biomarkers for celiac sprue. Chemistry & Biology. 16: 868-81. PMID 19716477 DOI: 10.1016/j.chembiol.2009.07.009  1
2009 Khosla C. Structures and mechanisms of polyketide synthases. The Journal of Organic Chemistry. 74: 6416-20. PMID 19711990 DOI: 10.1021/jo9012089  1
2009 Ehren J, Morón B, Martin E, Bethune MT, Gray GM, Khosla C. A food-grade enzyme preparation with modest gluten detoxification properties. Plos One. 4: e6313. PMID 19621078 DOI: 10.1371/journal.pone.0006313  1
2009 Das A, Khosla C. Biosynthesis of aromatic polyketides in bacteria. Accounts of Chemical Research. 42: 631-9. PMID 19292437 DOI: 10.1021/ar8002249  1
2009 Bethune MT, Siegel M, Howles-Banerji S, Khosla C. Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides. The Journal of Pharmacology and Experimental Therapeutics. 329: 657-68. PMID 19218531 DOI: 10.1124/jpet.108.148007  1
2009 Khosla C, Kapur S, Cane DE. Revisiting the modularity of modular polyketide synthases. Current Opinion in Chemical Biology. 13: 135-43. PMID 19217343 DOI: 10.1016/j.cbpa.2008.12.018  1
2009 Lord-Dufour S, Copland IB, Levros LC, Post M, Das A, Khosla C, Galipeau J, Rassart E, Annabi B. Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells. Stem Cells (Dayton, Ohio). 27: 489-97. PMID 19074414 DOI: 10.1634/stemcells.2008-0855  1
2009 Khosla C. Modular biocatalysts Aiche Journal. 55: 1926-1929. DOI: 10.1002/aic.11981  1
2009 Liu CW, Alekseyev VY, Allwardt JR, Bankovich AJ, Cade-Menun BJ, Davis RW, Du LS, Garcia KC, Herschlag D, Khosla C, Kraut DA, Li Q, Null B, Puglisi JD, Sigala PA, et al. The diversity of nuclear magnetic resonance spectroscopy Nato Science For Peace and Security Series B: Physics and Biophysics. 65-81.  1
2008 Ehren J, Govindarajan S, Morón B, Minshull J, Khosla C. Protein engineering of improved prolyl endopeptidases for celiac sprue therapy. Protein Engineering, Design & Selection : Peds. 21: 699-707. PMID 18836204 DOI: 10.1093/protein/gzn050  1
2008 Lu X, Vora H, Khosla C. Overproduction of free fatty acids in E. coli: implications for biodiesel production. Metabolic Engineering. 10: 333-9. PMID 18812230 DOI: 10.1016/j.ymben.2008.08.006  1
2008 Kapur S, Khosla C. Biochemistry: Fit for an enzyme. Nature. 454: 832-3. PMID 18704072 DOI: 10.1038/454832a  1
2008 Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. Journal of the American Chemical Society. 130: 11598-9. PMID 18693734 DOI: 10.1021/ja804453p  1
2008 Yuan L, Behdad A, Siegel M, Khosla C, Higashikubo R, Rich KM. Tissue transgluaminase 2 expression in meningiomas. Journal of Neuro-Oncology. 90: 125-32. PMID 18587533 DOI: 10.1007/s11060-008-9642-1  1
2008 Morón B, Bethune MT, Comino I, Manyani H, Ferragud M, López MC, Cebolla A, Khosla C, Sousa C. Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide. Plos One. 3: e2294. PMID 18509534 DOI: 10.1371/journal.pone.0002294  1
2008 Bethune MT, Khosla C. Parallels between pathogens and gluten peptides in celiac sprue. Plos Pathogens. 4: e34. PMID 18425213 DOI: 10.1371/journal.ppat.0040034  1
2008 Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Omary MB, Khosla C. Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. Plos One. 3: e1861. PMID 18365016 DOI: 10.1371/journal.pone.0001861  1
2008 Bethune MT, Ribka E, Khosla C, Sestak K. Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques. Plos One. 3: e1857. PMID 18365012 DOI: 10.1371/journal.pone.0001857  1
2008 Bethune MT, Borda JT, Ribka E, Liu MX, Phillippi-Falkenstein K, Jandacek RJ, Doxiadis GG, Gray GM, Khosla C, Sestak K. A non-human primate model for gluten sensitivity. Plos One. 3: e1614. PMID 18286171 DOI: 10.1371/journal.pone.0001614  0.84
2008 Ridley CP, Lee HY, Khosla C. Evolution of polyketide synthases in bacteria. Proceedings of the National Academy of Sciences of the United States of America. 105: 4595-600. PMID 18250311 DOI: 10.1073/pnas.0710107105  1
2008 Kapur S, Worthington A, Tang Y, Cane DE, Burkart MD, Khosla C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 18: 3034-8. PMID 18243693 DOI: 10.1016/j.bmcl.2008.01.073  1
2008 Ehren J, Khosla C. Oral glutenase therapy for celiac sprue Pediatric and Adolescent Medicine. 12: 148-156. DOI: 10.1159/000128996  1
2008 Tse ML, Khosla C. Engineering and Overproduction of Polyketide Natural Products Modern Biopharmaceuticals: Design, Development and Optimization. 4: 1803-1832. DOI: 10.1002/9783527620982.ch74  1
2008 Schnarr NA, Khosla C. Diversity-oriented Synthesis: Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 2: 519-536. DOI: 10.1002/9783527619375.ch9b  1
2008 Vora H, Lu X, Khosla C. Scaleable production of free fatty acids in E. Coli: Implications for biodiesel production Aiche Annual Meeting, Conference Proceedings 1
2007 Pinkas DM, Strop P, Brunger AT, Khosla C. Transglutaminase 2 undergoes a large conformational change upon activation. Plos Biology. 5: e327. PMID 18092889 DOI: 10.1371/journal.pbio.0050327  1
2007 Castonguay R, He W, Chen AY, Khosla C, Cane DE. Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 129: 13758-69. PMID 17918944 DOI: 10.1021/ja0753290  1
2007 Alekseyev VY, Liu CW, Cane DE, Puglisi JD, Khosla C. Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase. Protein Science : a Publication of the Protein Society. 16: 2093-107. PMID 17893358 DOI: 10.1110/ps.073011407  1
2007 Tang Y, Chen AY, Kim CY, Cane DE, Khosla C. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chemistry & Biology. 14: 931-43. PMID 17719492 DOI: 10.1016/j.chembiol.2007.07.012  1
2007 Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM. Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Bioorganic & Medicinal Chemistry. 15: 6565-73. PMID 17681795 DOI: 10.1016/j.bmc.2007.07.001  1
2007 Gass J, Bethune MT, Siegel M, Spencer A, Khosla C. Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology. 133: 472-80. PMID 17681168 DOI: 10.1053/j.gastro.2007.05.028  1
2007 Chen AY, Cane DE, Khosla C. Structure-based dissociation of a type I polyketide synthase module. Chemistry & Biology. 14: 784-92. PMID 17656315 DOI: 10.1016/j.chembiol.2007.05.015  1
2007 Gass J, Vora H, Hofmann AF, Gray GM, Khosla C. Enhancement of dietary protein digestion by conjugated bile acids. Gastroenterology. 133: 16-23. PMID 17631126 DOI: 10.1053/j.gastro.2007.04.008  1
2007 Siegel M, Xia J, Khosla C. Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. Bioorganic & Medicinal Chemistry. 15: 6253-61. PMID 17590341 DOI: 10.1016/j.bmc.2007.06.020  1
2007 Siegel M, Khosla C. Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacology & Therapeutics. 115: 232-45. PMID 17582505 DOI: 10.1016/j.pharmthera.2007.05.003  1
2007 Lee TS, Das A, Khosla C. Structure-activity relationships of semisynthetic mumbaistatin analogs. Bioorganic & Medicinal Chemistry. 15: 5207-18. PMID 17524653 DOI: 10.1016/j.bmc.2007.05.019  1
2007 Katz L, Khosla C. Antibiotic production from the ground up. Nature Biotechnology. 25: 428-9. PMID 17420748 DOI: 10.1038/nbt0407-428  1
2007 Strnad P, Harada M, Siegel M, Terkeltaub RA, Graham RM, Khosla C, Omary MB. Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology. 132: 1515-26. PMID 17408647 DOI: 10.1053/j.gastro.2007.02.020  1
2007 Vora H, McIntire J, Kumar P, Deshpande M, Khosla C. A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue. Biotechnology and Bioengineering. 98: 177-85. PMID 17385743 DOI: 10.1002/bit.21423  1
2007 Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual Review of Biochemistry. 76: 195-221. PMID 17328673 DOI: 10.1146/annurev.biochem.76.053105.093515  1
2007 Tse ML, Watts RE, Khosla C. Substrate tolerance of module 6 of the epothilone synthetase. Biochemistry. 46: 3385-93. PMID 17315981 DOI: 10.1021/bi0616448  1
2007 Lee HY, Khosla C. Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli. Plos Biology. 5: e45. PMID 17298179 DOI: 10.1371/journal.pbio.0050045  1
2007 Gass J, Khosla C. Prolyl endopeptidases. Cellular and Molecular Life Sciences : Cmls. 64: 345-55. PMID 17160352 DOI: 10.1007/s00018-006-6317-y  1
2007 Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene. 26: 2563-73. PMID 17099729 DOI: 10.1038/sj.onc.1210048  1
2007 Shan L, Khosla C. Chemistry and biology of gluten proteins Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7: 187-193. DOI: 10.2174/187152207780832397  1
2006 Schnarr NA, Khosla C. Trapping transient protein-protein interactions in polyketide biosynthesis. Acs Chemical Biology. 1: 679-80. PMID 17184129 DOI: 10.1021/cb600451d  1
2006 Watts RE, Siegel M, Khosla C. Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. Journal of Medicinal Chemistry. 49: 7493-501. PMID 17149878 DOI: 10.1021/jm060839a  1
2006 Tang Y, Lee HY, Tang Y, Kim CY, Mathews I, Khosla C. Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry. 45: 14085-93. PMID 17115703 DOI: 10.1021/bi061187v  1
2006 Rude MA, Khosla C. Production of ansamycin polyketide precursors in Escherichia coli. The Journal of Antibiotics. 59: 464-70. PMID 17080682 DOI: 10.1038/ja.2006.65  1
2006 Tang Y, Kim CY, Mathews II, Cane DE, Khosla C. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 11124-9. PMID 16844787 DOI: 10.1073/pnas.0601924103  1
2006 Siegel M, Bethune MT, Gass J, Ehren J, Xia J, Johannsen A, Stuge TB, Gray GM, Lee PP, Khosla C. Rational design of combination enzyme therapy for celiac sprue. Chemistry & Biology. 13: 649-58. PMID 16793522 DOI: 10.1016/j.chembiol.2006.04.009  1
2006 Bethune MT, Strop P, Tang Y, Sollid LM, Khosla C. Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chemistry & Biology. 13: 637-47. PMID 16793521 DOI: 10.1016/j.chembiol.2006.04.008  1
2006 Gass J, Vora H, Bethune MT, Gray GM, Khosla C. Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat. The Journal of Pharmacology and Experimental Therapeutics. 318: 1178-86. PMID 16757540 DOI: 10.1124/jpet.106.104315  1
2006 Hicks LM, Mazur MT, Miller LM, Dorrestein PC, Schnarr NA, Khosla C, Kelleher NL. Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. Chembiochem : a European Journal of Chemical Biology. 7: 904-7. PMID 16642537 DOI: 10.1002/cbic.200500416  1
2006 Strnad P, Siegel M, Toivola DM, Choi K, Kosek JC, Khosla C, Omary MB. Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation. Febs Letters. 580: 2351--2357. PMID 16616523 DOI: 10.1016/j.febslet.2006.03.051  1
2006 Chen AY, Schnarr NA, Kim CY, Cane DE, Khosla C. Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 128: 3067-74. PMID 16506788 DOI: 10.1021/ja058093d  1
2006 Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C. Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin. Journal of the American Chemical Society. 128: 1859-67. PMID 16464085 DOI: 10.1021/ja056423o  1
2006 He W, Wu J, Khosla C, Cane DE. Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase. Bioorganic & Medicinal Chemistry Letters. 16: 391-4. PMID 16249083 DOI: 10.1016/j.bmcl.2005.09.077  1
2006 Moffet DA, Khosla C, Cane DE. Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2. Bioorganic & Medicinal Chemistry Letters. 16: 213-6. PMID 16213712 DOI: 10.1016/j.bmcl.2005.09.017  1
2006 Pinkas DM, Strop P, Khosla C, Clark JH. A peptide inhibitor reveals an extended conformation of Transglutaminase 2 Aiche Annual Meeting, Conference Proceedings 1
2005 Lee TS, Khosla C, Tang Y. Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases. The Journal of Antibiotics. 58: 663-6. PMID 16392683 DOI: 10.1038/ja.2005.91  1
2005 Wu J, Zaleski TJ, Valenzano C, Khosla C, Cane DE. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. Journal of the American Chemical Society. 127: 17393-404. PMID 16332089 DOI: 10.1021/ja055672+  1
2005 Sollid LM, Khosla C. Future therapeutic options for celiac disease. Nature Clinical Practice. Gastroenterology & Hepatology. 2: 140-7. PMID 16265155 DOI: 10.1038/ncpgasthep0111  1
2005 Wu J, He W, Khosla C, Cane DE. Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. Angewandte Chemie (International Ed. in English). 44: 7557-60. PMID 16247819 DOI: 10.1002/anie.200502246  1
2005 Khosla C, Gray GM, Sollid LM. Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides. Gastroenterology. 129: 1362-3; author reply. PMID 16230098 DOI: 10.1053/j.gastro.2005.08.044  1
2005 Shan L, Qiao SW, Arentz-Hansen H, Molberg Ø, Gray GM, Sollid LM, Khosla C. Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. Journal of Proteome Research. 4: 1732-41. PMID 16212427 DOI: 10.1021/pr050173t  1
2005 Pyle GG, Paaso B, Anderson BE, Allen DD, Marti T, Li Q, Siegel M, Khosla C, Gray GM. Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 3: 687-94. PMID 16206502 DOI: 10.1016/S1542-3565(05)00366-6  1
2005 Pyle GG, Paaso B, Anderson BE, Allen D, Marti T, Khosla C, Gray GM. Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 3: 679-86. PMID 16206501 DOI: 10.1016/S1542-3565(05)00365-4  1
2005 Yuan L, Choi K, Khosla C, Zheng X, Higashikubo R, Chicoine MR, Rich KM. Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Molecular Cancer Therapeutics. 4: 1293-302. PMID 16170020 DOI: 10.1158/1535-7163.MCT-04-0328  1
2005 Gass J, Ehren J, Strohmeier G, Isaacs I, Khosla C. Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. Biotechnology and Bioengineering. 92: 674-84. PMID 16136593 DOI: 10.1002/bit.20643  1
2005 Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. Journal of the American Chemical Society. 127: 12254-62. PMID 16131203 DOI: 10.1021/ja051429z  1
2005 Schnarr NA, Chen AY, Cane DE, Khosla C. Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. Biochemistry. 44: 11836-42. PMID 16128585 DOI: 10.1021/bi0510781  1
2005 Schnarr NA, Khosla C. Biological chemistry: just add chlorine. Nature. 436: 1094-5. PMID 16121161 DOI: 10.1038/4361094a  1
2005 Hartung IV, Rude MA, Schnarr NA, Hunziker D, Khosla C. Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis. Journal of the American Chemical Society. 127: 11202-3. PMID 16089423 DOI: 10.1021/ja051430y  1
2005 Choi K, Siegel M, Piper JL, Yuan L, Cho E, Strnad P, Omary B, Rich KM, Khosla C. Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chemistry & Biology. 12: 469-75. PMID 15850984 DOI: 10.1016/j.chembiol.2005.02.007  1
2005 Khosla C, Tang Y. Chemistry. A new route to designer antibiotics. Science (New York, N.Y.). 308: 367-8. PMID 15831747 DOI: 10.1126/science.1111415  1
2005 Bergseng E, Xia J, Kim CY, Khosla C, Sollid LM. Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule. The Journal of Biological Chemistry. 280: 21791-6. PMID 15826953 DOI: 10.1074/jbc.M501558200  1
2005 Xia J, Sollid LM, Khosla C. Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. Biochemistry. 44: 4442-9. PMID 15766274 DOI: 10.1021/bi047747c  1
2005 Shan L, Mathews II, Khosla C. Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proceedings of the National Academy of Sciences of the United States of America. 102: 3599-604. PMID 15738423 DOI: 10.1073/pnas.0408286102  1
2005 Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM. Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease. Journal of Immunology (Baltimore, Md. : 1950). 174: 1657-63. PMID 15661929  1
2005 Marti T, Molberg Ø, Li Q, Gray GM, Khosla C, Sollid LM. Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: Chemical and immunological characterization Journal of Pharmacology and Experimental Therapeutics. 312: 19-26. PMID 15358813 DOI: 10.1124/jpet.104.073312  1
2004 Wu J, Kinoshita K, Khosla C, Cane DE. Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Biochemistry. 43: 16301-10. PMID 15610024 DOI: 10.1021/bi048147g  1
2004 Diacovich L, Mitchell DL, Pham H, Gago G, Melgar MM, Khosla C, Gramajo H, Tsai SC. Crystal structure of the β-subunit of acyl-CoA carboxylase: Structure-based engineering of substrate specificity Biochemistry. 43: 14027-14036. PMID 15518551 DOI: 10.1021/bi049065v  1
2004 Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry. 43: 13892-8. PMID 15518537 DOI: 10.1021/bi048418n  1
2004 Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. Journal of the American Chemical Society. 126: 9924-5. PMID 15303858 DOI: 10.1021/ja048836f  1
2004 Kumar P, Khosla C, Tang Y. Manipulation and analysis of polyketide synthases. Methods in Enzymology. 388: 269-93. PMID 15289078 DOI: 10.1016/S0076-6879(04)88023-6  1
2004 Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM. An antibiotic factory caught in action. Nature Structural & Molecular Biology. 11: 888-93. PMID 15286722 DOI: 10.1038/nsmb808  1
2004 Qiao SW, Bergseng E, Molberg Ø, Xia J, Fleckenstein B, Khosla C, Sollid LM. Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. Journal of Immunology (Baltimore, Md. : 1950). 173: 1757-62. PMID 15265905  1
2004 Tang Y, Koppisch AT, Khosla C. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry. 43: 9546-55. PMID 15260498 DOI: 10.1021/bi049157k  1
2004 Shan L, Marti T, Sollid LM, Gray GM, Khosla C. Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. The Biochemical Journal. 383: 311-8. PMID 15245330 DOI: 10.1042/BJ20040907  1
2004 Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C. Precursor-directed biosynthesis of epothilone in Escherichia coli. Journal of the American Chemical Society. 126: 7436-7. PMID 15198579 DOI: 10.1021/ja048108s  1
2004 Piper JL, Gray GM, Khosla C. Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo. The Journal of Pharmacology and Experimental Therapeutics. 311: 213-9. PMID 15143130 DOI: 10.1124/jpet.104.068429  1
2004 Kim CY, Quarsten H, Bergseng E, Khosla C, Sollid LM. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4175-9. PMID 15020763 DOI: 10.1073/pnas.0306885101  1
2004 Tang Y, Lee TS, Khosla C. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. Plos Biology. 2: E31. PMID 14966533 DOI: 10.1371/journal.pbio.0020031  1
2004 Tang Y, Lee TS, Lee HY, Khosla C. Exploring the biosynthetic potential of bimodular aromatic polyketide synthases Tetrahedron. 60: 7659-7671. DOI: 10.1016/j.tet.2004.05.118  1
2004 Rude MA, Khosla C. Engineered biosynthesis of polyketides in heterologous hosts Chemical Engineering Science. 59: 4693-4701. DOI: 10.1016/j.ces.2004.09.026  1
2003 Kumar P, Koppisch AT, Cane DE, Khosla C. Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. Journal of the American Chemical Society. 125: 14307-12. PMID 14624579 DOI: 10.1021/ja037429l  1
2003 Watanabe K, Khosla C, Stroud RM, Tsai SC. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. 334: 435-44. PMID 14623185 DOI: 10.1016/j.jmb.2003.10.021  1
2003 Pfeifer BA, Wang CC, Walsh CT, Khosla C. Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Applied and Environmental Microbiology. 69: 6698-702. PMID 14602630 DOI: 10.1128/AEM.69.11.6698-6702.2003  1
2003 Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/ja0378759  1
2003 Kinoshita K, Pfeifer BA, Khosla C, Cane DE. Precursor-Directed polyketide biosynthesis in Escherichia coli. Bioorganic & Medicinal Chemistry Letters. 13: 3701-4. PMID 14552761 DOI: 10.1016/j.bmcl.2003.08.008  1
2003 Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. The Journal of Biological Chemistry. 278: 42020-6. PMID 12923197 DOI: 10.1074/jbc.M305339200  1
2003 Hu Z, Pfeifer BA, Chao E, Murli S, Kealey J, Carney JR, Ashley G, Khosla C, Hutchinson CR. A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. Microbiology (Reading, England). 149: 2213-25. PMID 12904561  1
2003 Watanabe K, Rude MA, Walsh CT, Khosla C. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 9774-8. PMID 12888623 DOI: 10.1073/pnas.1632167100  1
2003 Tang Y, Lee TS, Kobayashi S, Khosla C. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry. 42: 6588-95. PMID 12767243 DOI: 10.1021/bi0341962  1
2003 Liou GF, Khosla C. Building-block selectivity of polyketide synthases. Current Opinion in Chemical Biology. 7: 279-84. PMID 12714062 DOI: 10.1016/S1367-5931(03)00016-4  1
2003 Kumar P, Li Q, Cane DE, Khosla C. Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition. Journal of the American Chemical Society. 125: 4097-102. PMID 12670230 DOI: 10.1021/ja0297537  1
2003 Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. Journal of the American Chemical Society. 125: 3428-9. PMID 12643694 DOI: 10.1021/ja0298646  1
2003 Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (London, England : 1993). 11: 147-54. PMID 12575934 DOI: 10.1016/S0969-2126(03)00004-2  1
2003 Liou GF, Lau J, Cane DE, Khosla C. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. Biochemistry. 42: 200-7. PMID 12515555 DOI: 10.1021/bi0268100  1
2002 Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (London, England : 1993). 10: 1559-68. PMID 12429097 DOI: 10.1016/S0969-2126(02)00889-4  1
2002 Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. 41: 12598-606. PMID 12379102 DOI: 10.1021/bi0260177  1
2002 Lu H, Tsai SC, Khosla C, Cane DE. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry. 41: 12590-7. PMID 12379101 DOI: 10.1021/bi026006d  1
2002 Shan L, Molberg Ø, Parrot I, Hausch F, Filiz F, Gray GM, Sollid LM, Khosla C. Structural basis for gluten intolerance in celiac sprue. Science (New York, N.Y.). 297: 2275-9. PMID 12351792 DOI: 10.1126/science.1074129  1
2002 Hausch F, Shan L, Santiago NA, Gray GM, Khosla C. Intestinal digestive resistance of immunodominant gliadin peptides. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G996-G1003. PMID 12223360 DOI: 10.1152/ajpgi.00136.2002  1
2002 Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry. 41: 5193-201. PMID 11955068 DOI: 10.1021/bi015593k  1
2002 Wu N, Cane DE, Khosla C. Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. Biochemistry. 41: 5056-66. PMID 11939803 DOI: 10.1021/bi012086u  1
2002 Piper JL, Gray GM, Khosla C. High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue. Biochemistry. 41: 386-93. PMID 11772038 DOI: 10.1021/bi011715x  1
2001 Wu N, Tsuji SY, Cane DE, Khosla C. Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules. Journal of the American Chemical Society. 123: 6465-74. PMID 11439032 DOI: 10.1021/ja010219t  1
2001 Salomon AR, Zhang Y, Seto H, Khosla C. Structure-activity relationships within a family of selectively cytotoxic macrolide natural products. Organic Letters. 3: 57-9. PMID 11429871 DOI: 10.1021/ol006767d  1
2001 Tsuji SY, Cane DE, Khosla C. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. Biochemistry. 40: 2326-31. PMID 11327852 DOI: 10.1021/bi002463n  1
2001 Tsuji SY, Wu N, Khosla C. Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins. Biochemistry. 40: 2317-25. PMID 11327851 DOI: 10.1021/bi002462v  1
2001 Pfeifer BA, Khosla C. Biosynthesis of polyketides in heterologous hosts. Microbiology and Molecular Biology Reviews : Mmbr. 65: 106-18. PMID 11238987 DOI: 10.1128/MMBR.65.1.106-118.2001  1
2001 Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science (New York, N.Y.). 291: 1790-2. PMID 11230695 DOI: 10.1126/science.1058092  1
2001 Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chemistry & Biology. 8: 71-80. PMID 11182320 DOI: 10.1016/S1074-5521(00)00057-0  0.52
2000 Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proceedings of the National Academy of Sciences of the United States of America. 97: 14766-71. PMID 11121076 DOI: 10.1073/pnas.97.26.14766  0.52
2000 Lau J, Cane DE, Khosla C. Substrate specificity of the loading didomain of the erythromycin polyketide synthase. Biochemistry. 39: 10514-20. PMID 10956042 DOI: 10.1021/bi000602v  1
1999 Gokhale RS, Tsuji SY, Cane DE, Khosla C. Dissecting and exploiting intermodular communication in polyketide synthases. Science (New York, N.Y.). 284: 482-5. PMID 10205055 DOI: 10.1126/science.284.5413.482  1
1999 Lau J, Fu H, Cane DE, Khosla C. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. Biochemistry. 38: 1643-51. PMID 9931032 DOI: 10.1021/bi9820311  1
1998 Gokhale RS, Lau J, Cane DE, Khosla C. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase. Biochemistry. 37: 2524-8. PMID 9485401 DOI: 10.1021/bi971887n  1
1996 Alvarez MA, Fu H, Khosla C, Hopwood DA, Bailey JE. Engineered biosynthesis of novel polyketides: properties of the whiE aromatase/cyclase. Nature Biotechnology. 14: 335-8. PMID 9630896 DOI: 10.1038/nbt0396-335  0.92
1996 Fu H, Alvarez MA, Khosla C, Bailey JE. Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase. Biochemistry. 35: 6527-32. PMID 8639600 DOI: 10.1021/bi952957y  0.92
1990 Bailey JE, Birnbaum S, Galazzo JL, Khosla C, Shanks JV. Strategies and challenges in metabolic engineering. Annals of the New York Academy of Sciences. 589: 1-15. PMID 2192652 DOI: 10.1111/j.1749-6632.1990.tb24230.x  1
1990 Khosla C, Curtis JE, Bydalek P, Swartz JR, Bailey JE. Expression of recombinant proteins in Escherichia coli using an oxygen-responsive promoter. Bio/Technology (Nature Publishing Company). 8: 554-8. PMID 1367436 DOI: 10.1038/nbt0690-554  1
1990 Khosla C, Curtis JE, DeModena J, Rinas U, Bailey JE. Expression of intracellular hemoglobin improves protein synthesis in oxygen-limited Escherichia coli. Bio/Technology (Nature Publishing Company). 8: 849-53. PMID 1366796 DOI: 10.1038/nbt0990-849  1
1989 Hughes DE, Curtis JE, Khosla C, Bailey JE. A new oxygen-regulated promoter for the expression of proteins in Escherichia coli. Biotechniques. 7: 1026-8. PMID 2698665  1
1989 Khosla C, Bailey JE. Evidence for partial export of Vitreoscilla hemoglobin into the periplasmic space in Escherichia coli. Implications for protein function. Journal of Molecular Biology. 210: 79-89. PMID 2685332  0.92
1989 Khosla C, Bailey JE. Characterization of the oxygen-dependent promoter of the Vitreoscilla hemoglobin gene in Escherichia coli. Journal of Bacteriology. 171: 5995-6004. PMID 2681149  0.92
1988 Khosla C, Bailey JE. Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli. Nature. 331: 633-5. PMID 3277067 DOI: 10.1038/331633a0  0.92
1988 Khosla C, Bailey JE. The Vitreoscilla hemoglobin gene: molecular cloning, nucleotide sequence and genetic expression in Escherichia coli. Molecular & General Genetics : Mgg. 214: 158-61. PMID 3067078  0.92
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