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Brian K. Hubbard, Ph.D. - Publications

Affiliations: 
2000 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
structure/function relationships for enzyme-catalyzed reactions
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2008 Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase Biochemistry. 47: 9944-9954. PMID 18754693 DOI: 10.1021/Bi800914R  0.588
2002 Pootoolal J, Thomas MG, Marshall CG, Neu JM, Hubbard BK, Walsh CT, Wright GD. Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proceedings of the National Academy of Sciences of the United States of America. 99: 8962-7. PMID 12060705 DOI: 10.1073/Pnas.102285099  0.364
2002 Chen H, Hubbard BK, O'Connor SE, Walsh CT. Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics. Chemistry & Biology. 9: 103-12. PMID 11841943 DOI: 10.1016/S1074-5521(02)00090-X  0.491
2001 Chen H, Tseng CC, Hubbard BK, Walsh CT. Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine. Proceedings of the National Academy of Sciences of the United States of America. 98: 14901-6. PMID 11752437 DOI: 10.1073/Pnas.221582098  0.405
2001 Schmidt DMZ, Hubbard BK, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: Functional assignment of unknown proteins in bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases Biochemistry. 40: 15707-15715. PMID 11747447 DOI: 10.1021/Bi011640X  0.675
2001 Walsh CT, Chen H, Keating TA, Hubbard BK, Losey HC, Luo L, Marshall CG, Miller DA, Patel HM. Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines. Current Opinion in Chemical Biology. 5: 525-34. PMID 11578925 DOI: 10.1016/S1367-5931(00)00235-0  0.304
2001 Chen H, Thomas MG, O'Connor SE, Hubbard BK, Burkart MD, Walsh CT. Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics. Biochemistry. 40: 11651-9. PMID 11570865 DOI: 10.1021/Bi0115434  0.397
2001 Gulick AM, Hubbard BK, Gerlt JA, Rayment I. Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli. Biochemistry. 40: 10054-62. PMID 11513584 DOI: 10.1021/Bi010733B  0.642
2001 Chiu HT, Hubbard BK, Shah AN, Eide J, Fredenburg RA, Walsh CT, Khosla C. Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 98: 8548-53. PMID 11447274 DOI: 10.1073/Pnas.151246498  0.352
2000 Hubbard BK, Thomas MG, Walsh CT. Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. Chemistry & Biology. 7: 931-42. PMID 11137816 DOI: 10.1016/S1074-5521(00)00043-0  0.38
2000 Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 97: 11942-7. PMID 11035791 DOI: 10.1073/Pnas.210395097  0.475
2000 Gulick AM, Hubbard BK, Gerlt JA, Rayment I. Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli. Biochemistry. 39: 4590-602. PMID 10769114 DOI: 10.1021/Bi992782I  0.671
1998 Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli. Biochemistry. 37: 14369-75. PMID 9772162 DOI: 10.1021/Bi981124F  0.6
1998 Palmer DR, Hubbard BK, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: partitioning of reactive intermediates by (D)-glucarate dehydratase from Pseudomonas putida. Biochemistry. 37: 14350-7. PMID 9772160 DOI: 10.1021/Bi981122V  0.645
1997 Palmer DRJ, Wieczorek SJ, Hubbard BK, Mrachko GT, Gerlt JA. Importance of mechanistic imperatives in enzyme-catalyzed β-elimination reactions: Stereochemical consequences of the dehydration reactions catalyzed by D-galactonate dehydratase from Escherichia coli and D-glucarate dehydratase from Pseudomonas putida Journal of the American Chemical Society. 119: 9580-9581. DOI: 10.1021/Ja970977C  0.589
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