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Steven C. Almo - Publications

Affiliations: 
Biochemistry Yeshiva University, New York, NY, United States 
Area:
Biochemistry
Website:
http://www.einstein.yu.edu/faculty/7091/steven-almo/
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290 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yuan Y, Zallot R, Grove TL, Payan DJ, Martin-Verstraete I, Šepić S, Balamkundu S, Neelakandan R, Gadi VK, Liu CF, Swairjo MA, Dedon PC, Almo SC, Gerlt JA, de Crécy-Lagard V. Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens. Proceedings of the National Academy of Sciences of the United States of America. PMID 31481610 DOI: 10.1073/pnas.1909604116  0.32
2019 Wang H, Fedorov AA, Fedorov EV, Hunt DM, Rodgers A, Douglas HL, Garza-Garcia A, Bonanno JB, Almo SC, de Carvalho LPS. An essential bifunctional enzyme in for itaconate dissimilation and leucine catabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 31320588 DOI: 10.1073/pnas.1906606116  0.68
2019 Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC. Structural Basis of CD160:HVEM Recognition. Structure (London, England : 1993). PMID 31230945 DOI: 10.1016/j.str.2019.05.010  0.68
2019 Shrestha R, Garrett SC, Almo SC, Fiser A. Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity. Structure (London, England : 1993). PMID 30930066 DOI: 10.1016/j.str.2019.03.006  0.4
2019 Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, De Larrea CF, Olson E, ... ... Almo SC, et al. GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells. Science Translational Medicine. 11. PMID 30918115 DOI: 10.1126/scitranslmed.aau7746  0.52
2019 Ng SL, Leno-Duran E, Samanta D, Almo SC, Strominger JL. Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30683721 DOI: 10.1073/pnas.1811984116  0.52
2018 Nemmara V, Xiang DF, Fedorov A, Fedorov EV, Bonanno JB, Almo SC, Raushel FM. Substrate Profile of the Phosphotriesterase Homology Protein from Escherichia coli. Biochemistry. PMID 30277746 DOI: 10.1021/acs.biochem.8b00935  0.68
2018 Bouvier JT, Sernova NV, Ghasempur S, Rodionova IA, Vetting MW, Al-Obaidi NF, Almo SC, Gerlt JA, Rodionov DA. Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria. Journal of Bacteriology. PMID 30249705 DOI: 10.1128/JB.00431-18  0.32
2018 Ryu H, Grove TL, Almo SC, Kim J. Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. Nucleic Acids Research. PMID 29982645 DOI: 10.1093/nar/gky592  0.48
2018 Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC. Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature. PMID 29980769 DOI: 10.1038/s41586-018-0355-0  0.76
2018 Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC. A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature. PMID 29925952 DOI: 10.1038/s41586-018-0238-4  0.76
2018 Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA. Functional assignment of multiple catabolic pathways for D-apiose. Nature Chemical Biology. PMID 29867142 DOI: 10.1038/s41589-018-0067-7  1
2018 Odokonyero D, McMillan AW, Ramagopal UA, Toro R, Truong DP, Zhu M, Lopez MS, Somiari B, Herman M, Aziz A, Bonanno JB, Hull KG, Burley SK, Romo D, Almo SC, et al. Comparison of Alicyclobacillus acidocaldarius OSBS to its promiscuous NSAR/OSBS relatives. Biochemistry. PMID 29767960 DOI: 10.1021/acs.biochem.8b00088  0.68
2018 Smith EL, Staehr M, Masakayan R, Tatake IJ, Purdon TJ, Wang X, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Riviere I, Liu C, Brentjens RJ. Development and Evaluation of an Optimal Human Single-Chain Variable Fragment-Derived BCMA-Targeted CAR T Cell Vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29678657 DOI: 10.1016/j.ymthe.2018.03.016  0.52
2018 Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, et al. Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581255 DOI: 10.1073/pnas.1801524115  0.68
2018 Barr I, Stich TA, Gizzi AS, Grove TL, Bonanno JB, Latham JA, Chung T, Wilmot CM, Britt RD, Almo SC, Klinman JP. X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE. Biochemistry. PMID 29405700 DOI: 10.1021/acs.biochem.7b01097  0.68
2018 Calhoun S, Korczynska M, Wichelecki DJ, San Francisco B, Zhao S, Rodionov DA, Vetting MW, Al-Obaidi NF, Lin H, O'Meara MJ, Scott DA, Morris JH, Russel D, Almo SC, Osterman AL, et al. Prediction of enzymatic pathways by integrative pathway mapping. Elife. 7. PMID 29377793 DOI: 10.7554/eLife.31097  0.4
2017 Sheng X, Patskovsky Y, Vladimirova A, Bonanno JB, Almo SC, Himo F, Raushel FM. Mechanism and Structure of γ-Resorcylate Decarboxylase. Biochemistry. PMID 29283551 DOI: 10.1021/acs.biochem.7b01213  0.68
2017 Ghosh A, Ramagopal UA, Bonanno JB, Brenowitz MD, Almo SC. Structures of the L27 domain of Disc Large homolog 1 protein illustrate a self-assembly module. Biochemistry. PMID 29261291 DOI: 10.1021/acs.biochem.7b01074  0.68
2017 Ohaegbulam KC, Liu W, Jeon H, Almo SC, Zang X. Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells. Oncotarget. 8: 82740-82753. PMID 29137299 DOI: 10.18632/oncotarget.21098  0.68
2017 Chen J, Almo SC, Wu Y. General principles of binding between cell surface receptors and multi-specific ligands: A computational study. Plos Computational Biology. 13: e1005805. PMID 29016600 DOI: 10.1371/journal.pcbi.1005805  1
2017 Grove TL, Himes PM, Hwang S, Yumerefendi H, Bonanno JB, Kuhlman B, Almo SC, Bowers AA. Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides. Journal of the American Chemical Society. PMID 28704043 DOI: 10.1021/jacs.7b01283  0.68
2017 Hegde RP, Chinnaswamy PG, Dey D, Almo SC, Ramakumar S, Ramagopal UA. Can the propensity of protein crystallization be increased by using systematic screening with metals? Protein Science : a Publication of the Protein Society. PMID 28643473 DOI: 10.1002/pro.3214  0.52
2017 Ramagopal UA, Liu W, Garrett-Thomson SC, Bonanno JB, Yan Q, Srinivasan M, Wong SC, Bell A, Mankikar S, Rangan VS, Deshpande S, Korman AJ, Almo SC. Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484017 DOI: 10.1073/pnas.1617941114  0.68
2017 Hegde RP, Fedorov AA, Sauder JM, Burley SK, Almo SC, Ramagopal UA. The hidden treasure in your data: phasing with unexpected weak anomalous scatterers from routine data sets. Acta Crystallographica. Section F, Structural Biology Communications. 73: 184-195. PMID 28368276 DOI: 10.1107/S2053230X17002680  0.68
2017 Metcalf B, Chuang C, Dufu K, Patel MP, Silva-Garcia A, Johnson C, Lu Q, Partridge JR, Patskovska L, Patskovsky Y, Almo SC, Jacobson MP, Hua L, Xu Q, Gwaltney SL, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. Acs Medicinal Chemistry Letters. 8: 321-326. PMID 28337324 DOI: 10.1021/acsmedchemlett.6b00491  0.64
2017 Park HB, Sampathkumar P, Perez CE, Lee JH, Tran J, Bonanno JB, Hallem EA, Almo SC, Crawford JM. Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis. The Journal of Biological Chemistry. PMID 28246174 DOI: 10.1074/jbc.M116.762542  0.68
2017 Lázár-Molnár E, Scandiuzzi L, Basu I, Quinn T, Sylvestre E, Palmieri E, Ramagopal UA, Nathenson SG, Guha C, Almo SC. Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy. Ebiomedicine. PMID 28233730 DOI: 10.1016/j.ebiom.2017.02.004  1
2017 Upla P, Kim SJ, Sampathkumar P, Dutta K, Cahill SM, Chemmama IE, Williams R, Bonanno JB, Rice WJ, Stokes DL, Cowburn D, Almo SC, Sali A, Rout MP, Fernandez-Martinez J. Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex. Structure (London, England : 1993). PMID 28162953 DOI: 10.1016/j.str.2017.01.006  0.68
2017 Rodionova IA, Vetting MW, Li X, Almo SC, Osterman AL, Rodionov DA. A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea. Nucleic Acids Research. PMID 28073944 DOI: 10.1093/nar/gkw1331  0.32
2016 Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC. Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2. Molecular Immunology. 81: 151-159. PMID 27978489 DOI: 10.1016/j.molimm.2016.12.003  0.52
2016 Liu W, Ramagopal U, Cheng H, Bonanno JB, Toro R, Bhosle R, Zhan C, Almo SC. Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure (London, England : 1993). 24: 2016-2023. PMID 27806260 DOI: 10.1016/j.str.2016.09.009  0.68
2016 Wang Y, Wach JY, Sheehan P, Zhong C, Zhan C, Harris R, Almo SC, Bishop J, Haggarty SJ, Ramek A, Berry KN, O'Herin C, Koehler AN, Hung AW, Young DW. Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β. Acs Medicinal Chemistry Letters. 7: 852-6. PMID 27660690 DOI: 10.1021/acsmedchemlett.6b00230  0.4
2016 McClelland EE, Ramagopal UA, Rivera J, Cox J, Nakouzi A, Prabu MM, Almo SC, Casadevall A. A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals. Plos Pathogens. 12: e1005849. PMID 27583447 DOI: 10.1371/journal.ppat.1005849  0.52
2016 Liu W, Almo SC, Zang X. Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go? Immunological Investigations. 1-19. PMID 27419268 DOI: 10.1080/08820139.2016.1186690  0.68
2016 Zhang X, Carter MS, Vetting MW, San Francisco B, Zhao S, Al-Obaidi NF, Solbiati JO, Thiaville JJ, de Crécy-Lagard V, Jacobson MP, Almo SC, Gerlt JA. Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402745 DOI: 10.1073/pnas.1605546113  1
2016 Oksenberg D, Dufu K, Patel MP, Chuang C, Li Z, Xu Q, Silva-Garcia A, Zhou C, Hutchaleelaha A, Patskovska L, Patskovsky Y, Almo SC, Sinha U, Metcalf BW, Archer DR. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. British Journal of Haematology. PMID 27378309 DOI: 10.1111/bjh.14214  0.64
2016 Yadava U, Vetting MW, Al Obaidi N, Carter MS, Gerlt JA, Almo SC. Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine. Acta Crystallographica. Section F, Structural Biology Communications. 72: 467-472. PMID 27303900 DOI: 10.1107/S2053230X16007500  1
2016 Boskovic ZV, Kemp MM, Freedy AM, Viswanathan VS, Pop MS, Fuller JH, Martinez NM, Figuero Lazu SO, Hong JA, Lewis TA, Calarese D, Love JD, Vetere A, Almo SC, Schreiber SL, et al. Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. Acs Chemical Biology. PMID 27064299 DOI: 10.1021/acschembio.6b00012  0.4
2016 Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA. Correction to "A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis". Journal of the American Chemical Society. PMID 26978037 DOI: 10.1021/jacs.6b01906  0.68
2016 Carlucci L, Zhou E, Malashkevich V, Almo SC, Mundorff EC. Biochemical characterization of two haloalkane dehalogenases: DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea. Protein Science : a Publication of the Protein Society. PMID 26833751 DOI: 10.1002/pro.2895  1
2016 Vetting MW, Bouvier JT, Gerlt JA, Almo SC. Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation. Acta Crystallographica. Section F, Structural Biology Communications. 72: 36-41. PMID 26750482 DOI: 10.1107/S2053230X15023286  1
2016 Vladimirova A, Patskovsky Y, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Hillerich B, Seidel RD, Richards NG, Almo SC, Raushel FM. Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase. Journal of the American Chemical Society. 138: 826-36. PMID 26714575 DOI: 10.1021/jacs.5b08251  0.68
2015 Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA. A General Strategy for the Discovery of Metabolic Pathways: D-Threitol, L-Threitol, and Erythritol Utilization in Mycobacterium smegmatis. Journal of the American Chemical Society. PMID 26560079 DOI: 10.1021/jacs.5b08968  0.52
2015 Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA. ABC Transport System Solute Binding Protein-Guided Identification of Novel D-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciencs C58. The Journal of Biological Chemistry. PMID 26472925 DOI: 10.1074/jbc.M115.686857  0.52
2015 Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD. Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes. Acs Central Science. 1: 77-82. PMID 26258173 DOI: 10.1021/acscentsci.5b00115  0.32
2015 Liu W, Vigdorovich V, Zhan C, Patskovsky Y, Bonanno JB, Nathenson SG, Almo SC. Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM. Molecular Biotechnology. PMID 26202493 DOI: 10.1007/s12033-015-9881-2  0.52
2015 Zheng H, Handing KB, Zimmerman MD, Shabalin IG, Almo SC, Minor W. X-ray crystallography over the past decade for novel drug discovery - where are we heading next? Expert Opinion On Drug Discovery. 1-15. PMID 26177814 DOI: 10.1517/17460441.2015.1061991  0.52
2015 Chow JY, Tian BX, Ramamoorthy G, Hillerich BS, Seidel RD, Almo SC, Jacobson MP, Poulter CD. Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus. Proceedings of the National Academy of Sciences of the United States of America. 112: 5661-6. PMID 25901324 DOI: 10.1073/pnas.1505127112  1
2015 Xiang DF, Patskovsky Y, Nemmara VV, Toro R, Almo SC, Raushel FM. Function discovery and structural characterization of a methylphosphonate esterase. Biochemistry. 54: 2919-30. PMID 25873441 DOI: 10.1021/acs.biochem.5b00199  1
2015 Kim J, Xiao H, Koh J, Wang Y, Bonanno JB, Thomas K, Babbitt PC, Brown S, Lee YS, Almo SC. Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. Nucleic Acids Research. 43: 4602-13. PMID 25855808 DOI: 10.1093/nar/gkv206  1
2015 Huang H, Pandya C, Liu C, Al-Obaidi NF, Wang M, Zheng L, Toews Keating S, Aono M, Love JD, Evans B, Seidel RD, Hillerich BS, Garforth SJ, Almo SC, Mariano PS, et al. Panoramic view of a superfamily of phosphatases through substrate profiling. Proceedings of the National Academy of Sciences of the United States of America. 112: E1974-83. PMID 25848029 DOI: 10.1073/pnas.1423570112  1
2015 Thomas K, Cameron SA, Almo SC, Burgos ES, Gulab SA, Schramm VL. Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. Biochemistry. 54: 2520-9. PMID 25806409 DOI: 10.1021/bi501487w  1
2015 Malashkevich VN, Higgins CD, Almo SC, Lai JR. A switch from parallel to antiparallel strand orientation in a coiled-coil X-ray structure via two core hydrophobic mutations. Biopolymers. 104: 178-85. PMID 25753192 DOI: 10.1002/bip.22631  0.44
2015 Zhang X, Kumar R, Vetting MW, Zhao S, Jacobson MP, Almo SC, Gerlt JA. A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily. Journal of the American Chemical Society. 137: 1388-91. PMID 25608448 DOI: 10.1021/ja5103986  1
2015 Fedorov AA, Martí-Arbona R, Nemmara VV, Hitchcock D, Fedorov EV, Almo SC, Raushel FM. Structure of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa. Biochemistry. 54: 890-7. PMID 25559274 DOI: 10.1021/bi501299y  1
2015 Janakiram M, Chinai JM, Fineberg S, Fiser A, Montagna C, Medavarapu R, Castano E, Jeon H, Ohaegbulam KC, Zhao R, Zhao A, Almo SC, Sparano JA, Zang X. Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2359-66. PMID 25549724 DOI: 10.1158/1078-0432.CCR-14-1495  0.4
2015 Vetting MW, Al-Obaidi N, Zhao S, San Francisco B, Kim J, Wichelecki DJ, Bouvier JT, Solbiati JO, Vu H, Zhang X, Rodionov DA, Love JD, Hillerich BS, Seidel RD, Quinn RJ, ... ... Almo SC, et al. Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry. 54: 909-31. PMID 25540822 DOI: 10.1021/bi501388y  1
2015 London N, Farelli JD, Brown SD, Liu C, Huang H, Korczynska M, Al-Obaidi NF, Babbitt PC, Almo SC, Allen KN, Shoichet BK. Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases. Biochemistry. 54: 528-37. PMID 25513739 DOI: 10.1021/bi501140k  1
2015 Samanta D, Almo SC. Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity. Cellular and Molecular Life Sciences : Cmls. 72: 645-58. PMID 25326769 DOI: 10.1007/s00018-014-1763-4  1
2014 Jeon H, Vigdorovich V, Garrett-Thomson SC, Janakiram M, Ramagopal UA, Abadi YM, Lee JS, Scandiuzzi L, Ohaegbulam KC, Chinai JM, Zhao R, Yao Y, Mao Y, Sparano JA, Almo SC, et al. Structure and cancer immunotherapy of the B7 family member B7x. Cell Reports. 9: 1089-98. PMID 25437562 DOI: 10.1016/j.celrep.2014.09.053  1
2014 Hitchcock DS, Fedorov AA, Fedorov EV, Almo SC, Raushel FM. Discovery of a bacterial 5-methylcytosine deaminase. Biochemistry. 53: 7426-35. PMID 25384249 DOI: 10.1021/bi5012767  1
2014 Desai BJ, Goto Y, Cembran A, Fedorov AA, Almo SC, Gao J, Suga H, Gerlt JA. Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution. Proceedings of the National Academy of Sciences of the United States of America. 111: 15066-71. PMID 25275007 DOI: 10.1073/pnas.1411772111  1
2014 Piatkevich KD, English BP, Malashkevich VN, Xiao H, Almo SC, Singer RH, Verkhusha VV. Photoswitchable red fluorescent protein with a large Stokes shift. Chemistry & Biology. 21: 1402-14. PMID 25242289 DOI: 10.1016/j.chembiol.2014.08.010  1
2014 Manjasetty BA, Chance MR, Burley SK, Panjikar S, Almo SC. Crystal structure of Clostridium acetobutylicum Aspartate kinase (CaAK): An important allosteric enzyme for amino acids production. Biotechnology Reports (Amsterdam, Netherlands). 3: 73-85. PMID 25170437 DOI: 10.1016/j.btre.2014.06.009  1
2014 Wichelecki DJ, Vendiola JA, Jones AM, Al-Obaidi N, Almo SC, Gerlt JA. Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate. Biochemistry. 53: 5692-9. PMID 25145794 DOI: 10.1021/bi500837w  1
2014 Kim SJ, Fernandez-Martinez J, Sampathkumar P, Martel A, Matsui T, Tsuruta H, Weiss TM, Shi Y, Markina-Inarrairaegui A, Bonanno JB, Sauder JM, Burley SK, Chait BT, Almo SC, Rout MP, et al. Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex. Molecular & Cellular Proteomics : McP. 13: 2911-26. PMID 25139911 DOI: 10.1074/mcp.M114.040915  1
2014 Liu W, Zhan C, Cheng H, Kumar PR, Bonanno JB, Nathenson SG, Almo SC. Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure (London, England : 1993). 22: 1252-62. PMID 25087510 DOI: 10.1016/j.str.2014.06.013  1
2014 Lamont D, Mukherjee G, Kumar PR, Samanta D, McPhee CG, Kay TW, Almo SC, DiLorenzo TP, Serreze DV. Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 193: 2135-46. PMID 25063871 DOI: 10.4049/jimmunol.1400997  0.68
2014 Almo SC, Guha C. Considerations for combined immune checkpoint modulation and radiation treatment. Radiation Research. 182: 230-8. PMID 25003312 DOI: 10.1667/RR13667.1  1
2014 Zhao S, Sakai A, Zhang X, Vetting MW, Kumar R, Hillerich B, San Francisco B, Solbiati J, Steves A, Brown S, Akiva E, Barber A, Seidel RD, Babbitt PC, Almo SC, et al. Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks. Elife. 3. PMID 24980702 DOI: 10.7554/eLife.03275  1
2014 Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM. l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota. Biochemistry. 53: 4661-70. PMID 24963813 DOI: 10.1021/bi500656m  1
2014 Pletnev S, Shcherbakova DM, Subach OM, Pletneva NV, Malashkevich VN, Almo SC, Dauter Z, Verkhusha VV. Orange fluorescent proteins: structural studies of LSSmOrange, PSmOrange and PSmOrange2. Plos One. 9: e99136. PMID 24960050 DOI: 10.1371/journal.pone.0099136  0.44
2014 Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, et al. Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. Biochemistry. 53: 4727-38. PMID 24955762 DOI: 10.1021/bi500595c  1
2014 Wichelecki DJ, Graff DC, Al-Obaidi N, Almo SC, Gerlt JA. Identification of the in vivo function of the high-efficiency D-mannonate dehydratase in Caulobacter crescentus NA1000 from the enolase superfamily. Biochemistry. 53: 4087-9. PMID 24947666 DOI: 10.1021/bi500683x  1
2014 Groninger-Poe FP, Bouvier JT, Vetting MW, Kalyanaraman C, Kumar R, Almo SC, Jacobson MP, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: galactarate dehydratase III from Agrobacterium tumefaciens C58. Biochemistry. 53: 4192-203. PMID 24926996 DOI: 10.1021/bi5005377  1
2014 Odokonyero D, Sakai A, Patskovsky Y, Malashkevich VN, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Agarwal R, Wang C, Ozerova ND, Yew WS, Sauder JM, Swaminathan S, Burley SK, ... Almo SC, et al. Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family. Proceedings of the National Academy of Sciences of the United States of America. 111: 8535-40. PMID 24872444 DOI: 10.1073/pnas.1318703111  1
2014 Ghasempur S, Eswaramoorthy S, Hillerich BS, Seidel RD, Swaminathan S, Almo SC, Gerlt JA. Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1. Biochemistry. 53: 3357-66. PMID 24831290 DOI: 10.1021/bi5004298  1
2014 Barelier S, Cummings JA, Rauwerdink AM, Hitchcock DS, Farelli JD, Almo SC, Raushel FM, Allen KN, Shoichet BK. Substrate deconstruction and the nonadditivity of enzyme recognition. Journal of the American Chemical Society. 136: 7374-82. PMID 24791931 DOI: 10.1021/ja501354q  1
2014 Mashiyama ST, Malabanan MM, Akiva E, Bhosle R, Branch MC, Hillerich B, Jagessar K, Kim J, Patskovsky Y, Seidel RD, Stead M, Toro R, Vetting MW, Almo SC, Armstrong RN, et al. Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere. Plos Biology. 12: e1001843. PMID 24756107 DOI: 10.1371/journal.pbio.1001843  1
2014 Higgins CD, Malashkevich VN, Almo SC, Lai JR. Influence of a heptad repeat stutter on the pH-dependent conformational behavior of the central coiled-coil from influenza hemagglutinin HA2. Proteins. 82: 2220-8. PMID 24753307 DOI: 10.1002/prot.24585  1
2014 Almo SC, Love JD. Better and faster: improvements and optimization for mammalian recombinant protein production. Current Opinion in Structural Biology. 26: 39-43. PMID 24721463 DOI: 10.1016/j.sbi.2014.03.006  1
2014 Wichelecki DJ, Balthazor BM, Chau AC, Vetting MW, Fedorov AA, Fedorov EV, Lukk T, Patskovsky YV, Stead MB, Hillerich BS, Seidel RD, Almo SC, Gerlt JA. Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the d-mannonate dehydratase subgroup Biochemistry. 53: 2722-2731. PMID 24697546 DOI: 10.1021/bi500264p  1
2014 Wengerter BC, Katakowski JA, Rosenberg JM, Park CG, Almo SC, Palliser D, Levy M. Aptamer-targeted antigen delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1375-87. PMID 24682172 DOI: 10.1038/mt.2014.51  1
2014 Donaldson TM, Cassera MB, Ho MC, Zhan C, Merino EF, Evans GB, Tyler PC, Almo SC, Schramm VL, Kim K. Inhibition and structure of Toxoplasma gondii purine nucleoside phosphorylase. Eukaryotic Cell. 13: 572-9. PMID 24585883 DOI: 10.1128/EC.00308-13  1
2014 Padlan CS, Malashkevich VN, Almo SC, Levy M, Brenowitz M, Girvin ME. An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates. Rna (New York, N.Y.). 20: 447-61. PMID 24570482 DOI: 10.1261/rna.043034.113  1
2014 Khafizov K, Madrid-Aliste C, Almo SC, Fiser A. Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative. Proceedings of the National Academy of Sciences of the United States of America. 111: 3733-8. PMID 24567391 DOI: 10.1073/pnas.1321614111  1
2014 Scandiuzzi L, Ghosh K, Hofmeyer KA, Abadi YM, Lázár-Molnár E, Lin EY, Liu Q, Jeon H, Almo SC, Chen L, Nathenson SG, Zang X. Tissue-expressed B7-H1 critically controls intestinal inflammation. Cell Reports. 6: 625-32. PMID 24529703 DOI: 10.1016/j.celrep.2014.01.020  1
2014 Kumar R, Zhao S, Vetting MW, Wood BM, Sakai A, Cho K, Solbiati J, Almo SC, Sweedler JV, Jacobson MP, Gerlt JA, Cronan JE. Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine. Mbio. 5: e00933-13. PMID 24520058 DOI: 10.1128/mBio.00933-13  0.32
2014 Bouvier JT, Groninger-Poe FP, Vetting M, Almo SC, Gerlt JA. Galactaro δ-lactone isomerase: Lactone isomerization by a member of the amidohydrolase superfamily Biochemistry. 53: 614-616. PMID 24450804 DOI: 10.1021/bi5000492  1
2014 Donaldson TM, Ting LM, Zhan C, Shi W, Zheng R, Almo SC, Kim K. Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase. Plos One. 9: e84384. PMID 24416224 DOI: 10.1371/journal.pone.0084384  1
2014 Cummings JA, Vetting M, Ghodge SV, Xu C, Hillerich B, Seidel RD, Almo SC, Raushel FM. Prospecting for unannotated enzymes: discovery of a 3',5'-nucleotide bisphosphate phosphatase within the amidohydrolase superfamily. Biochemistry. 53: 591-600. PMID 24401123 DOI: 10.1021/bi401640r  1
2014 Koellhoffer JF, Dai Z, Malashkevich VN, Stenglein MD, Liu Y, Toro R, S Harrison J, Chandran K, DeRisi JL, Almo SC, Lai JR. Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species. Journal of Molecular Biology. 426: 1452-68. PMID 24333483 DOI: 10.1016/j.jmb.2013.12.009  1
2014 Bandaranayake AD, Almo SC. Recent advances in mammalian protein production. Febs Letters. 588: 253-60. PMID 24316512 DOI: 10.1016/j.febslet.2013.11.035  1
2013 Ramagopal UA, Dulyaninova NG, Varney KM, Wilder PT, Nallamsetty S, Brenowitz M, Weber DJ, Almo SC, Bresnick AR. Structure of the S100A4/myosin-IIA complex. Bmc Structural Biology. 13: 31. PMID 24252706 DOI: 10.1186/1472-6807-13-31  1
2013 Malashkevich VN, Almo SC, Dowd TL. X-ray crystal structure of bovine 3 Glu-osteocalcin. Biochemistry. 52: 8387-92. PMID 24138653 DOI: 10.1021/bi4010254  1
2013 Odokonyero D, Ragumani S, Lopez MS, Bonanno JB, Ozerova ND, Woodard DR, Machala BW, Swaminathan S, Burley SK, Almo SC, Glasner ME. Divergent evolution of ligand binding in the o-succinylbenzoate synthase family. Biochemistry. 52: 7512-21. PMID 24060347 DOI: 10.1021/bi401176d  0.68
2013 Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP. Discovery of new enzymes and metabolic pathways by using structure and genome context. Nature. 502: 698-702. PMID 24056934 DOI: 10.1038/nature12576  0.68
2013 Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM. Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes. Biochemistry. 52: 6525-36. PMID 23972005 DOI: 10.1021/bi400750a  1
2013 Hitchcock DS, Fan H, Kim J, Vetting M, Hillerich B, Seidel RD, Almo SC, Shoichet BK, Sali A, Raushel FM. Structure-guided discovery of new deaminase enzymes. Journal of the American Chemical Society. 135: 13927-33. PMID 23968233 DOI: 10.1021/ja4066078  1
2013 Daughtry KD, Huang H, Malashkevich V, Patskovsky Y, Liu W, Ramagopal U, Sauder JM, Burley SK, Almo SC, Dunaway-Mariano D, Allen KN. Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis. Biochemistry. 52: 5372-86. PMID 23848398 DOI: 10.1021/bi400659k  1
2013 Miller PW, Pokutta S, Ghosh A, Almo SC, Weis WI, Nelson WJ, Kwiatkowski AV. Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin. The Journal of Biological Chemistry. 288: 22324-32. PMID 23788645 DOI: 10.1074/jbc.M113.458406  1
2013 Haapalainen AM, Thomas K, Tyler PC, Evans GB, Almo SC, Schramm VL. Salmonella enterica MTAN at 1.36 Ã… resolution: a structure-based design of tailored transition state analogs. Structure (London, England : 1993). 21: 963-74. PMID 23685211 DOI: 10.1016/j.str.2013.04.009  1
2013 Piatkevich KD, Malashkevich VN, Morozova KS, Nemkovich NA, Almo SC, Verkhusha VV. Extended Stokes shift in fluorescent proteins: chromophore-protein interactions in a near-infrared TagRFP675 variant. Scientific Reports. 3: 1847. PMID 23677204 DOI: 10.1038/srep01847  1
2013 Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC. Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. Nature. 498: 123-6. PMID 23676670 DOI: 10.1038/nature12180  0.68
2013 Almo SC, Garforth SJ, Hillerich BS, Love JD, Seidel RD, Burley SK. Protein production from the structural genomics perspective: achievements and future needs. Current Opinion in Structural Biology. 23: 335-44. PMID 23642905 DOI: 10.1016/j.sbi.2013.02.014  1
2013 Kim J, Almo SC. Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. Bmc Structural Biology. 13: 5. PMID 23617613 DOI: 10.1186/1472-6807-13-5  1
2013 Vigdorovich V, Ramagopal UA, Lázár-Molnár E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC. Structure and T cell inhibition properties of B7 family member, B7-H3. Structure (London, England : 1993). 21: 707-17. PMID 23583036 DOI: 10.1016/j.str.2013.03.003  1
2013 Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A. Functional classification of immune regulatory proteins. Structure (London, England : 1993). 21: 766-76. PMID 23583034 DOI: 10.1016/j.str.2013.02.022  1
2013 Soniat M, Sampathkumar P, Collett G, Gizzi AS, Banu RN, Bhosle RC, Chamala S, Chowdhury S, Fiser A, Glenn AS, Hammonds J, Hillerich B, Khafizov K, Love JD, Matikainen B, ... ... Almo SC, et al. Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. Journal of Structural and Functional Genomics. 14: 31-5. PMID 23535894 DOI: 10.1007/s10969-013-9150-1  1
2013 Sampathkumar P, Kim SJ, Upla P, Rice WJ, Phillips J, Timney BL, Pieper U, Bonanno JB, Fernandez-Martinez J, Hakhverdyan Z, Ketaren NE, Matsui T, Weiss TM, Stokes DL, Sauder JM, ... ... Almo SC, et al. Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex. Structure (London, England : 1993). 21: 560-71. PMID 23499021 DOI: 10.1016/j.str.2013.02.005  1
2013 Wallrapp FH, Pan JJ, Ramamoorthy G, Almonacid DE, Hillerich BS, Seidel R, Patskovsky Y, Babbitt PC, Almo SC, Jacobson MP, Poulter CD. Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 110: E1196-202. PMID 23493556 DOI: 10.1073/pnas.1300632110  1
2013 Kellett WF, Brunk E, Desai BJ, Fedorov AA, Almo SC, Gerlt JA, Rothlisberger U, Richards NG. Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase. Biochemistry. 52: 1842-4. PMID 23452154 DOI: 10.1021/bi400093y  0.68
2013 Ho MC, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK, Brenowitz M, Cheng RH, Reimer U, Almo SC, Shechter D. Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity. Plos One. 8: e57008. PMID 23451136 DOI: 10.1371/journal.pone.0057008  1
2013 Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, Schramm VL. Catalytic site conformations in human PNP by 19F-NMR and crystallography. Chemistry & Biology. 20: 212-22. PMID 23438750 DOI: 10.1016/j.chembiol.2013.01.009  1
2013 Cook I, Wang T, Almo SC, Kim J, Falany CN, Leyh TS. Testing the sulfotransferase molecular pore hypothesis. The Journal of Biological Chemistry. 288: 8619-26. PMID 23362278 DOI: 10.1074/jbc.M112.445015  1
2013 Ghodge SV, Fedorov AA, Fedorov EV, Hillerich B, Seidel R, Almo SC, Raushel FM. Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins. Biochemistry. 52: 1101-12. PMID 23327428 DOI: 10.1021/bi301496p  1
2013 Cook I, Wang T, Almo SC, Kim J, Falany CN, Leyh TS. The gate that governs sulfotransferase selectivity. Biochemistry. 52: 415-24. PMID 23256751 DOI: 10.1021/bi301492j  1
2013 Fan H, Hitchcock DS, Seidel RD, Hillerich B, Lin H, Almo SC, Sali A, Shoichet BK, Raushel FM. Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking. Journal of the American Chemical Society. 135: 795-803. PMID 23256477 DOI: 10.1021/ja309680b  1
2013 Hobbs ME, Vetting M, Williams HJ, Narindoshvili T, Kebodeaux DM, Hillerich B, Seidel RD, Almo SC, Raushel FM. Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily. Biochemistry. 52: 239-53. PMID 23214453 DOI: 10.1021/bi3015554  1
2012 Guan R, Ho MC, Fröhlich RF, Tyler PC, Almo SC, Schramm VL. Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. Biochemistry. 51: 9094-103. PMID 23050701 DOI: 10.1021/bi301062y  1
2012 Warlick BP, Evans BS, Erb TJ, Ramagopal UA, Sriram J, Imker HJ, Sauder JM, Bonanno JB, Burley SK, Tabita FR, Almo SC, Sweedler JS, Gerlt JA. 1-methylthio-d-xylulose 5-phosphate methylsulfurylase: A novel route to 1-deoxy-d-xylulose 5-phosphate in Rhodospirillum rubrum Biochemistry. 51: 8324-8326. PMID 23035785 DOI: 10.1021/bi301215g  1
2012 Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Conformational changes in orotidine 5′-monophosphate decarboxylase: A structure-based explanation for how the 5′-phosphate group activates the enzyme Biochemistry. 51: 8665-8678. PMID 23030629 DOI: 10.1021/bi301188k  1
2012 Garside EL, Schellenberg MJ, Gesner EM, Bonanno JB, Sauder JM, Burley SK, Almo SC, Mehta G, Macmillan AM. Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases Rna. 18: 2020-2028. PMID 23006625 DOI: 10.1261/rna.033100.112  1
2012 Koellhoffer JF, Malashkevich VN, Harrison JS, Toro R, Bhosle RC, Chandran K, Almo SC, Lai JR. Crystal structure of the Marburg virus GP2 core domain in its postfusion conformation. Biochemistry. 51: 7665-75. PMID 22935026 DOI: 10.1021/bi300976m  1
2012 Samanta D, Ramagopal UA, Rubinstein R, Vigdorovich V, Nathenson SG, Almo SC. Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion. Proceedings of the National Academy of Sciences of the United States of America. 109: 14836-40. PMID 22927415 DOI: 10.1073/pnas.1212912109  1
2012 Wang S, Haapalainen AM, Yan F, Du Q, Tyler PC, Evans GB, Rinaldo-Matthis A, Brown RL, Norris GE, Almo SC, Schramm VL. A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori. Biochemistry. 51: 6892-4. PMID 22891633 DOI: 10.1021/bi3009664  1
2012 Sampathkumar P, Kim SJ, Manglicmot D, Bain KT, Gilmore J, Gheyi T, Phillips J, Pieper U, Fernandez-Martinez J, Franke JD, Matsui T, Tsuruta H, Atwell S, Thompson DA, Emtage JS, ... ... Almo SC, et al. Atomic structure of the nuclear pore complex targeting domain of a Nup116 homologue from the yeast, Candida glabrata. Proteins. 80: 2110-6. PMID 22544723 DOI: 10.1002/prot.24102  1
2012 Grubmeyer C, Hansen MR, Fedorov AA, Almo SC. Structure of Salmonella typhimurium OMP synthase in a complete substrate complex. Biochemistry. 51: 4397-405. PMID 22531064 DOI: 10.1021/bi300083p  1
2012 Hobbs ME, Malashkevich V, Williams HJ, Xu C, Sauder JM, Burley SK, Almo SC, Raushel FM. Structure and catalytic mechanism of LigI: insight into the amidohydrolase enzymes of cog3618 and lignin degradation. Biochemistry. 51: 3497-507. PMID 22475079 DOI: 10.1021/bi300307b  1
2012 Lukk T, Sakai A, Kalyanaraman C, Brown SD, Imker HJ, Song L, Fedorov AA, Fedorov EV, Toro R, Hillerich B, Seidel R, Patskovsky Y, Vetting MW, Nair SK, Babbitt PC, ... Almo SC, et al. Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 109: 4122-7. PMID 22392983 DOI: 10.1073/pnas.1112081109  1
2012 Xiang DF, Kolb P, Fedorov AA, Xu C, Fedorov EV, Narindoshivili T, Williams HJ, Shoichet BK, Almo SC, Raushel FM. Structure-based function discovery of an enzyme for the hydrolysis of phosphorylated sugar lactones. Biochemistry. 51: 1762-73. PMID 22313111 DOI: 10.1021/bi201838b  1
2012 Patel VL, Mitra S, Harris R, Buxbaum AR, Lionnet T, Brenowitz M, Girvin M, Levy M, Almo SC, Singer RH, Chao JA. Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control. Genes & Development. 26: 43-53. PMID 22215810 DOI: 10.1101/gad.177428.111  1
2012 Gerlt JA, Babbitt PC, Jacobson MP, Almo SC. Divergent evolution in enolase superfamily: strategies for assigning functions. The Journal of Biological Chemistry. 287: 29-34. PMID 22069326 DOI: 10.1074/jbc.R111.240945  1
2011 Cassera MB, Hazleton KZ, Merino EF, Obaldia N, Ho MC, Murkin AS, DePinto R, Gutierrez JA, Almo SC, Evans GB, Babu YS, Schramm VL. Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. Plos One. 6: e26916. PMID 22096507 DOI: 10.1371/journal.pone.0026916  1
2011 Gerlt JA, Allen KN, Almo SC, Armstrong RN, Babbitt PC, Cronan JE, Dunaway-Mariano D, Imker HJ, Jacobson MP, Minor W, Poulter CD, Raushel FM, Sali A, Shoichet BK, Sweedler JV. The Enzyme Function Initiative. Biochemistry. 50: 9950-62. PMID 21999478 DOI: 10.1021/bi201312u  0.68
2011 Guan R, Ho MC, Brenowitz M, Tyler PC, Evans GB, Almo SC, Schramm VL. Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase. Biochemistry. 50: 10408-17. PMID 21985704 DOI: 10.1021/bi201321x  1
2011 Huang H, Patskovsky Y, Toro R, Farelli JD, Pandya C, Almo SC, Allen KN, Dunaway-Mariano D. Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase. Biochemistry. 50: 8937-49. PMID 21894910 DOI: 10.1021/bi201181q  1
2011 Iiams V, Desai BJ, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA. Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Importance of residues in the orotate binding site Biochemistry. 50: 8497-8507. PMID 21870810 DOI: 10.1021/bi2012355  1
2011 Samanta D, Mukherjee G, Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC. Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 13682-7. PMID 21825122 DOI: 10.1073/pnas.1110971108  1
2011 Dulyaninova NG, Hite KM, Zencheck WD, Scudiero DA, Almo SC, Shoemaker RH, Bresnick AR. Cysteine 81 is critical for the interaction of s100a4 and myosin-IIA Biochemistry. 50: 7218-7227. PMID 21749055 DOI: 10.1021/bi200853y  1
2011 Hitchcock DS, Fedorov AA, Fedorov EV, Dangott LJ, Almo SC, Raushel FM. Rescue of the orphan enzyme isoguanine deaminase. Biochemistry. 50: 5555-7. PMID 21604715 DOI: 10.1021/bi200680y  1
2011 Hall RS, Fedorov AA, Xu C, Fedorov EV, Almo SC, Raushel FM. Three-dimensional structure and catalytic mechanism of cytosine deaminase. Biochemistry. 50: 5077-85. PMID 21545144 DOI: 10.1021/bi200483k  1
2011 Roche CJ, Malashkevich V, Balazs TC, Dantsker D, Chen Q, Moreira J, Almo SC, Friedman JM, Hirsch RE. Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide. The Journal of Biological Chemistry. 286: 23452-66. PMID 21531715 DOI: 10.1074/jbc.M110.183186  1
2011 Magalhães ML, Czekster CM, Guan R, Malashkevich VN, Almo SC, Levy M. Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding. Protein Science : a Publication of the Protein Society. 20: 1145-54. PMID 21520321 DOI: 10.1002/pro.642  1
2011 Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy strategies: the structure of TL1A:DcR3 complex. Structure (London, England : 1993). 19: 162-71. PMID 21300286 DOI: 10.1016/j.str.2010.12.004  1
2011 Cassera MB, Ho MC, Merino EF, Burgos ES, Rinaldo-Matthis A, Almo SC, Schramm VL. A high-affinity adenosine kinase from Anopheles gambiae. Biochemistry. 50: 1885-93. PMID 21247194 DOI: 10.1021/bi101921w  1
2011 Guan R, Ho MC, Almo SC, Schramm VL. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. Biochemistry. 50: 1247-54. PMID 21197954 DOI: 10.1021/bi101642d  1
2010 Tsai PC, Fan Y, Kim J, Yang L, Almo SC, Gao YQ, Raushel FM. Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase. Biochemistry. 49: 7988-97. PMID 20695627 DOI: 10.1021/bi101058z  1
2010 Piatkevich KD, Malashkevich VN, Almo SC, Verkhusha VV. Engineering ESPT pathways based on structural analysis of LSSmKate red fluorescent proteins with large stokes shift Journal of the American Chemical Society. 132: 10762-10770. PMID 20681709 DOI: 10.1021/ja101974k  1
2010 Seffernick JL, Reynolds E, Fedorov AA, Fedorov E, Almo SC, Sadowsky MJ, Wackett LP. X-ray structure and mutational analysis of the atrazine Chlorohydrolase TrzN. The Journal of Biological Chemistry. 285: 30606-14. PMID 20659898 DOI: 10.1074/jbc.M110.138677  1
2010 Li ZH, Dulyaninova NG, House RP, Almo SC, Bresnick AR. S100A4 regulates macrophage chemotaxis. Molecular Biology of the Cell. 21: 2598-610. PMID 20519440 DOI: 10.1091/mbc.E09-07-0609  1
2010 Sedeh RS, Fedorov AA, Fedorov EV, Ono S, Matsumura F, Almo SC, Bathe M. Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein. Journal of Molecular Biology. 400: 589-604. PMID 20434460 DOI: 10.1016/j.jmb.2010.04.043  1
2010 Subach OM, Malashkevich VN, Zencheck WD, Morozova KS, Piatkevich KD, Almo SC, Verkhusha VV. Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins. Chemistry & Biology. 17: 333-41. PMID 20416505 DOI: 10.1016/j.chembiol.2010.03.005  1
2010 Wood BM, Amyes TL, Fedorov AA, Fedorov EV, Shabila A, Almo SC, Richard JP, Gerlt JA. Conformational changes in orotidine 5′-monophosphate decarboxylase: "remote" residues that stabilize the active conformation Biochemistry. 49: 3514-3516. PMID 20369850 DOI: 10.1021/bi100443a  1
2010 Ho MC, Shi W, Rinaldo-Matthis A, Tyler PC, Evans GB, Clinch K, Almo SC, Schramm VL. Four generations of transition-state analogues for human purine nucleoside phosphorylase. Proceedings of the National Academy of Sciences of the United States of America. 107: 4805-12. PMID 20212140 DOI: 10.1073/pnas.0913439107  1
2010 Chao JA, Patskovsky Y, Patel V, Levy M, Almo SC, Singer RH. ZBP1 recognition of beta-actin zipcode induces RNA looping. Genes & Development. 24: 148-58. PMID 20080952 DOI: 10.1101/gad.1862910  1
2010 Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ. Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation. Journal of Immunology (Baltimore, Md. : 1950). 184: 1821-8. PMID 20065109 DOI: 10.4049/jimmunol.0902869  1
2010 Almo SC, Bresnick AR, Zhang X. Mechanistic features of cell-surface adhesion receptors Handbook of Cell Signaling, 2/E. 1: 63-69. DOI: 10.1016/B978-0-12-374145-5.00010-3  1
2009 Subach FV, Malashkevich VN, Zencheck WD, Xiao H, Filonov GS, Almo SC, Verkhusha VV. Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states. Proceedings of the National Academy of Sciences of the United States of America. 106: 21097-102. PMID 19934036 DOI: 10.1073/pnas.0909204106  1
2009 Ho MC, Sturm MB, Almo SC, Schramm VL. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 20276-81. PMID 19920175 DOI: 10.1073/pnas.0911606106  1
2009 Ho MC, Cassera MB, Madrid DC, Ting LM, Tyler PC, Kim K, Almo SC, Schramm VL. Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry. 48: 9618-26. PMID 19728741 DOI: 10.1021/bi9012484  1
2009 Nguyen TT, Fedorov AA, Williams L, Fedorov EV, Li Y, Xu C, Almo SC, Raushel FM. The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily. Biochemistry. 48: 8879-90. PMID 19678710 DOI: 10.1021/bi901046x  1
2009 Burgos ES, Ho MC, Almo SC, Schramm VL. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America. 106: 13748-53. PMID 19666527 DOI: 10.1073/pnas.0903898106  1
2009 Alvarado JJ, Nemkal A, Sauder JM, Russell M, Akiyoshi DE, Shi W, Almo SC, Weiss LM. Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Molecular and Biochemical Parasitology. 168: 158-67. PMID 19660503 DOI: 10.1016/j.molbiopara.2009.07.008  1
2009 Zhan C, Yan Q, Patskovsky Y, Li Z, Toro R, Meyer A, Cheng H, Brenowitz M, Nathenson SG, Almo SC. Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry. 48: 7636-45. PMID 19522538 DOI: 10.1021/bi900031w  1
2009 Cummings JA, Fedorov AA, Xu C, Brown S, Fedorov E, Babbitt PC, Almo SC, Raushel FM. Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily. Biochemistry. 48: 6469-81. PMID 19518059 DOI: 10.1021/bi900661b  1
2009 Chattopadhyay K, Lazar-Molnar E, Yan Q, Rubinstein R, Zhan C, Vigdorovich V, Ramagopal UA, Bonanno J, Nathenson SG, Almo SC. Sequence, structure, function, immunity: structural genomics of costimulation. Immunological Reviews. 229: 356-86. PMID 19426233 DOI: 10.1111/j.1600-065X.2009.00778.x  1
2009 Chattopadhyay K, Ramagopal UA, Nathenson SG, Almo SC. 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells. Acta Crystallographica. Section D, Biological Crystallography. 65: 434-9. PMID 19390148 DOI: 10.1107/S0907444909005721  1
2009 Zencheck WD, Xiao H, Nolen BJ, Angeletti RH, Pollard TD, Almo SC. Nucleotide- and activator-dependent structural and dynamic changes of arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry. Journal of Molecular Biology. 390: 414-27. PMID 19298826 DOI: 10.1016/j.jmb.2009.03.028  1
2009 Xiang DF, Patskovsky Y, Xu C, Meyer AJ, Sauder JM, Burley SK, Almo SC, Raushel FM. Functional identification of incorrectly annotated prolidases from the amidohydrolase superfamily of enzymes. Biochemistry. 48: 3730-42. PMID 19281183 DOI: 10.1021/bi900111q  1
2009 Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL. Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Nature Chemical Biology. 5: 251-7. PMID 19270684 DOI: 10.1038/nchembio.153  1
2008 Kim J, Tsai PC, Chen SL, Himo F, Almo SC, Raushel FM. Structure of diethyl phosphate bound to the binuclear metal center of phosphotriesterase. Biochemistry. 47: 9497-504. PMID 18702530 DOI: 10.1021/bi800971v  1
2008 Chan KK, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA. Structural basis for substrate specificity in phosphate binding (β/α)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12 Biochemistry. 47: 9608-9617. PMID 18700786 DOI: 10.1021/bi800821v  1
2008 Lázár-Molnár E, Yan Q, Cao E, Ramagopal U, Nathenson SG, Almo SC. Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proceedings of the National Academy of Sciences of the United States of America. 105: 10483-8. PMID 18641123 DOI: 10.1073/pnas.0804453105  1
2008 Lázár-Molnár E, Gácser A, Freeman GJ, Almo SC, Nathenson SG, Nosanchuk JD. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proceedings of the National Academy of Sciences of the United States of America. 105: 2658-63. PMID 18268348 DOI: 10.1073/pnas.0711918105  1
2008 Chattopadhyay K, Ramagopal UA, Brenowitz M, Nathenson SG, Almo SC. Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily. Proceedings of the National Academy of Sciences of the United States of America. 105: 635-40. PMID 18182486 DOI: 10.1073/pnas.0710529105  1
2008 Nguyen TT, Brown S, Fedorov AA, Fedorov EV, Babbitt PC, Almo SC, Raushel FM. At the periphery of the amidohydrolase superfamily: Bh0493 from Bacillus halodurans catalyzes the isomerization of D-galacturonate to D-tagaturonate. Biochemistry. 47: 1194-206. PMID 18171028 DOI: 10.1021/bi7017738  1
2008 Chao JA, Patskovsky Y, Almo SC, Singer RH. Structural basis for the coevolution of a viral RNA-protein complex. Nature Structural & Molecular Biology. 15: 103-5. PMID 18066080 DOI: 10.1038/nsmb1327  1
2007 Taylor EA, Rinaldo-Matthis A, Li L, Ghanem M, Hazleton KZ, Cassera MB, Almo SC, Schramm VL. Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition. Biochemistry. 46: 12405-15. PMID 17918964 DOI: 10.1021/bi7010256  1
2007 Wen SY, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2 Biochemistry. 46: 9564-9577. PMID 17649980 DOI: 10.1021/bi7008882  1
2007 Hermann JC, Marti-Arbona R, Fedorov AA, Fedorov E, Almo SC, Shoichet BK, Raushel FM. Structure-based activity prediction for an enzyme of unknown function. Nature. 448: 775-9. PMID 17603473 DOI: 10.1038/nature05981  1
2007 Hall RS, Brown S, Fedorov AA, Fedorov EV, Xu C, Babbitt PC, Almo SC, Raushel FM. Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase. Biochemistry. 46: 7953-62. PMID 17567048 DOI: 10.1021/bi700544c  1
2007 Yan Q, Malashkevich VN, Fedorov A, Fedorov E, Cao E, Lary JW, Cole JL, Nathenson SG, Almo SC. Structure of CD84 provides insight into SLAM family function. Proceedings of the National Academy of Sciences of the United States of America. 104: 10583-8. PMID 17563375 DOI: 10.1073/pnas.0703893104  1
2007 McLachlan GD, Cahill SM, Girvin ME, Almo SC. Acid-induced equilibrium folding intermediate of human platelet profilin. Biochemistry. 46: 6931-43. PMID 17511469 DOI: 10.1021/bi0602359  1
2007 Murkin AS, Birck MR, Rinaldo-Matthis A, Shi W, Taylor EA, Almo SC, Schramm VL. Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry. 46: 5038-49. PMID 17407325 DOI: 10.1021/bi700147b  1
2007 Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity. 26: 311-21. PMID 17363302 DOI: 10.1016/j.immuni.2007.01.016  1
2007 Imker HJ, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA. Mechanistic diversity in the RuBisCO superfamily: The "enolase" in the methionine salvage pathway in Geobacillus kaustophilus Biochemistry. 46: 4077-4089. PMID 17352497 DOI: 10.1021/bi7000483  1
2007 Kiselar JG, Mahaffy R, Pollard TD, Almo SC, Chance MR. Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 104: 1552-7. PMID 17251352 DOI: 10.1073/pnas.0605380104  1
2006 Lazar-Molnar E, Almo SC, Nathenson SG. The interchain disulfide linkage is not a prerequisite but enhances CD28 costimulatory function. Cellular Immunology. 244: 125-9. PMID 17467674 DOI: 10.1016/j.cellimm.2007.02.014  1
2006 Yew WS, Fedorov AA, Fedorov EV, Wood BM, Almo SC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: D-tartrate dehydratase from Bradyrhizobium japonicum Biochemistry. 45: 14598-14608. PMID 17144653 DOI: 10.1021/bi061688g  1
2006 Yew WS, Fedorov AA, Fedorov EV, Rakus JF, Pierce RW, Almo SC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris Biochemistry. 45: 14582-14597. PMID 17144652 DOI: 10.1021/bi061687o  1
2006 Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC. NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. Immunity. 25: 559-70. PMID 17045824 DOI: 10.1016/j.immuni.2006.06.020  1
2006 Chattopadhyay K, Bhatia S, Fiser A, Almo SC, Nathenson SG. Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein. Journal of Immunology (Baltimore, Md. : 1950). 177: 3920-9. PMID 16951355  1
2006 Kim J, Malashkevich V, Roday S, Lisbin M, Schramm VL, Almo SC. Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. Biochemistry. 45: 6407-16. PMID 16700551 DOI: 10.1021/bi0522394  1
2006 Patskovsky Y, Patskovska L, Almo SC, Listowsky I. Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a Biochemistry. 45: 3852-3862. PMID 16548513 DOI: 10.1021/bi051823+  1
2006 Akana J, Fedorov AA, Fedorov E, Novak WRP, Babbitt PC, Almo SC, Gerlt JA. D-ribulose 5-phosphate 3-epimerase: Functional and structural relationships to members of the ribulose-phosphate binding (β/α) 8-barrel superfamily Biochemistry. 45: 2493-2503. PMID 16489742 DOI: 10.1021/bi052474m  1
2006 Chiu W, Baker ML, Almo SC. Structural biology of cellular machines Trends in Cell Biology. 16: 144-150. PMID 16459078 DOI: 10.1016/j.tcb.2006.01.002  1
2006 Bhatia S, Edidin M, Almo SC, Nathenson SG. B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties. Immunology Letters. 104: 70-5. PMID 16413062 DOI: 10.1016/j.imlet.2005.11.019  1
2006 Roden MM, Brims DR, Fedorov AA, DiLorenzo TP, Almo SC, Nathenson SG. Structural analysis of H2-Db class I molecules containing two different allelic forms of the type 1 diabetes susceptibility factor beta-2 microglobulin: implications for the mechanism underlying variations in antigen presentation. Molecular Immunology. 43: 1370-8. PMID 16229893 DOI: 10.1016/j.molimm.2005.08.005  1
2005 Zhan C, Fedorov EV, Shi W, Ramagopal UA, Thirumuruhan R, Manjasetty BA, Almo SC, Fiser A, Chance MR, Fedorov AA. The ybeY protein from Escherichia coli is a metalloprotein. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 959-63. PMID 16511207 DOI: 10.1107/S1744309105031131  0.68
2005 Bhatia S, Edidin M, Almo SC, Nathenson SG. Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 15569-74. PMID 16221763 DOI: 10.1073/pnas.0507257102  1
2005 Parsa T, Cunningham SJ, Wall SP, Almo SC, Crain EF. The usefulness of urine fluorescence for suspected antifreeze ingestion in children. The American Journal of Emergency Medicine. 23: 787-92. PMID 16182989 DOI: 10.1016/j.ajem.2005.02.051  1
2005 Sun JP, Wang WQ, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry. 44: 12009-21. PMID 16142898 DOI: 10.1021/bi0509191  1
2005 Ramagopal UA, Dauter Z, Thirumuruhan R, Fedorov E, Almo SC. Radiation-induced site-specific damage of mercury derivatives: Phasing and implications Acta Crystallographica Section D: Biological Crystallography. 61: 1289-1298. PMID 16131763 DOI: 10.1107/S0907444905022316  1
2005 Tseng Y, Kole TP, Lee JS, Fedorov E, Almo SC, Schafer BW, Wirtz D. How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response. Biochemical and Biophysical Research Communications. 334: 183-92. PMID 15992772 DOI: 10.1016/j.bbrc.2005.05.205  1
2005 Quintero-Monzon O, Rodal AA, Strokopytov B, Almo SC, Goode BL. Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functions. Molecular Biology of the Cell. 16: 3128-39. PMID 15872087 DOI: 10.1091/mbc.E05-01-0059  1
2005 Dulyaninova NG, Malashkevich VN, Almo SC, Bresnick AR. Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation. Biochemistry. 44: 6867-76. PMID 15865432 DOI: 10.1021/bi0500776  1
2005 Patskovska LN, Patskovsky YV, Almo SC, Hirsch RE. COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000. Acta Crystallographica. Section D, Biological Crystallography. 61: 566-73. PMID 15858266 DOI: 10.1107/S0907444905004622  1
2005 Guan JQ, Takamoto K, Almo SC, Reisler E, Chance MR. Structure and dynamics of the actin filament. Biochemistry. 44: 3166-75. PMID 15736927 DOI: 10.1021/bi048021j  1
2005 Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC. Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches. Acta Crystallographica. Section D, Biological Crystallography. 61: 285-93. PMID 15735338 DOI: 10.1107/S0907444904033037  1
2004 Muhlrad A, Kudryashov D, Michael Peyser Y, Bobkov AA, Almo SC, Reisler E. Cofilin induced conformational changes in F-actin expose subdomain 2 to proteolysis. Journal of Molecular Biology. 342: 1559-67. PMID 15364581 DOI: 10.1016/j.jmb.2004.08.010  1
2004 Mattila PK, Quintero-Monzon O, Kugler J, Moseley JB, Almo SC, Lappalainen P, Goode BL. A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein. Molecular Biology of the Cell. 15: 5158-71. PMID 15356265 DOI: 10.1091/mbc.E04-06-0444  1
2004 Klein MG, Shi W, Ramagopal U, Tseng Y, Wirtz D, Kovar DR, Staiger CJ, Almo SC. Structure of the actin crosslinking core of fimbrin. Structure (London, England : 1993). 12: 999-1013. PMID 15274920 DOI: 10.1016/j.str.2004.04.010  1
2004 Mohri K, Vorobiev S, Fedorov AA, Almo SC, Ono S. Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments Journal of Biological Chemistry. 279: 31697-31707. PMID 15150269 DOI: 10.1074/jbc.M403351200  1
2004 Guan JQ, Almo SC, Chance MR. Synchrotron Radiolysis and Mass Spectrometry: A New Approach to Research on the Actin Cytoskeleton Accounts of Chemical Research. 37: 221-229. PMID 15096059 DOI: 10.1021/ar0302235  1
2004 Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC. Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity. 20: 337-47. PMID 15030777 DOI: 10.1016/S1074-7613(04)00051-2  1
2004 Bobkov AA, Muhlrad A, Shvetsov A, Benchaar S, Scoville D, Almo SC, Reisler E. Cofilin (ADF) affects lateral contacts in F-actin. Journal of Molecular Biology. 337: 93-104. PMID 15001354 DOI: 10.1016/j.jmb.2004.01.014  1
2004 Singh V, Shi W, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL. Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry. 43: 9-18. PMID 14705926 DOI: 10.1021/bi0358420  1
2003 Guan JQ, Almo SC, Reisler E, Chance MR. Structural reorganization of proteins revealed by radiolysis and mass spectrometry: G-actin solution structure is divalent cation dependent. Biochemistry. 42: 11992-2000. PMID 14556630 DOI: 10.1021/bi034914k  1
2003 Kiselar JG, Janmey PA, Almo SC, Chance MR. Structural analysis of gelsolin using synchrotron protein footprinting. Molecular & Cellular Proteomics : McP. 2: 1120-32. PMID 12966145 DOI: 10.1074/mcp.M300068-MCP200  1
2003 Huang RY, Boulton SJ, Vidal M, Almo SC, Bresnick AR, Chance MR. High-throughput expression, purification, and characterization of recombinant Caenorhabditis elegans proteins. Biochemical and Biophysical Research Communications. 307: 928-34. PMID 12878200 DOI: 10.1016/S0006-291X(03)01265-8  1
2003 Sun JP, Wu L, Fedorov AA, Almo SC, Zhang ZY. Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor Journal of Biological Chemistry. 278: 33392-33399. PMID 12810712 DOI: 10.1074/jbc.M304693200  1
2003 Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL. Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase. Biochemistry. 42: 6057-66. PMID 12755607 DOI: 10.1021/bi0343830  1
2003 Vorobiev S, Strokopytov B, Drubin DG, Frieden C, Ono S, Condeelis J, Rubenstein PA, Almo SC. The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism. Proceedings of the National Academy of Sciences of the United States of America. 100: 5760-5. PMID 12732734 DOI: 10.1073/pnas.0832273100  1
2003 Kiselar JG, Janmey PA, Almo SC, Chance MR. Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting Proceedings of the National Academy of Sciences of the United States of America. 100: 3942-3947. PMID 12655044 DOI: 10.1073/pnas.0736004100  1
2003 Zhang X, Schwartz JC, Almo SC, Nathenson SG. Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. Proceedings of the National Academy of Sciences of the United States of America. 100: 2586-91. PMID 12606712 DOI: 10.1073/pnas.252771499  1
2002 Dewan JC, Feeling-Taylor A, Puius YA, Patskovska L, Patskovsky Y, Nagel RL, Almo SC, Hirsch RE. Structure of mutant human carbonmonoxyhemoglobin C (betaE6K) at 2.0 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 58: 2038-42. PMID 12454462 DOI: 10.1107/S0907444902016426  1
2002 Bobkov AA, Muhlrad A, Kokabi K, Vorobiev S, Almo SC, Reisler E. Structural effects of cofilin on longitudinal contacts in F-actin. Journal of Molecular Biology. 323: 739-50. PMID 12419261 DOI: 10.1016/S0022-2836(02)01008-2  1
2002 Shi W, Sarver AE, Wang CC, Tanaka KSE, Almo SC, Schramm VL. Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration Journal of Biological Chemistry. 277: 39981-39988. PMID 12171925 DOI: 10.1074/jbc.M205596200  1
2002 Zhang X, Schwartz JC, Almo SC, Nathenson SG. Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2. Protein Expression and Purification. 25: 105-13. PMID 12071705 DOI: 10.1006/prep.2002.1616  1
2002 Tseng Y, Schafer BW, Almo SC, Wirtz D. Functional synergy of actin filament cross-linking proteins. The Journal of Biological Chemistry. 277: 25609-16. PMID 12006593 DOI: 10.1074/jbc.M202609200  1
2002 Guan JQ, Vorobiev S, Almo SC, Chance MR. Mapping the G-actin binding surface of cofilin using synchrotron protein footprinting Biochemistry. 41: 5765-5775. PMID 11980480 DOI: 10.1021/bi0121104  1
2002 Schwartz JC, Zhang X, Nathenson SG, Almo SC. Structural mechanisms of costimulation. Nature Immunology. 3: 427-34. PMID 11976720 DOI: 10.1038/ni0502-427  1
2002 Guan JQ, Almo SC, Chance MR. Probing the conformation difference between Ca 2+-ATP-actin and Mg 2+-ATP-actin by hydroxyl radicals and mass spectrometry Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 275-276.  1
2002 Kiselar JG, Almo SC, Janmey PA, Chance MR. Hydroxyl radical probe of Ca 2+ activated gelsolin structure using synchrotron X-ray radiolysis and mass spectrometry Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 363-364.  1
2001 Goldsmith SC, Guan JQ, Almo SC, Chance MR. Synchrotron protein footprinting: A technique to investigate protein-protein interactions Journal of Biomolecular Structure and Dynamics. 19: 405-418. PMID 11790140  1
2001 Shi W, Tanaka KSE, Crother TR, Taylor MW, Almo SC, Schramm VL. Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae Biochemistry. 40: 10800-10809. PMID 11535055 DOI: 10.1021/bi010465h  1
2001 Shi W, Basso LA, Santos DS, Tyler PC, Furneaux RH, Blanchard JS, Almo SC, Schramm VL. Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry. 40: 8204-15. PMID 11444966 DOI: 10.1021/bi010585p  1
2001 Tseng Y, Fedorov E, McCaffery JM, Almo SC, Wirtz D. Micromechanics and ultrastructure of actin filament networks crosslinked by human fascin: A comparison with α-actinin Journal of Molecular Biology. 310: 351-366. PMID 11428894 DOI: 10.1006/jmbi.2001.4716  1
2001 Zhang X, Schwartz JC, Nathenson SG, Almo SC. Crystallization and preliminary X-ray analysis of the complex between human CTLA-4 and B7-2. Acta Crystallographica. Section D, Biological Crystallography. 57: 898-9. PMID 11375523 DOI: 10.1107/S0907444901005777  1
2001 Rustandi R, Vallely KM, Varlamova O, Klein MG, Almo SC, Bresnick AR, Weber DJ. Letter to the editor: 1H, 13C, 15N NMR sequence-specific resonance assignments for human apo-Mts1 (S100A4) [3] Journal of Biomolecular Nmr. 19: 381-382. PMID 11370787 DOI: 10.1023/A:1011295415649  1
2001 Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature. 410: 604-8. PMID 11279501 DOI: 10.1038/35069112  1
2001 Tchaikovskaya T, Patskovsky YV, Federov A, Almo SC, Girvin M, Listowsky I. Interpreting the broad substrate specificities of glutathione S-transferases Chemico-Biological Interactions. 133: 170-172.  1
2000 Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science (New York, N.Y.). 290: 816-9. PMID 11052947 DOI: 10.1126/science.290.5492.816  1
2000 Wolven AK, Belmont LD, Mahoney NM, Almo SC, Drubin DG. In vivo importance of actin nucleotide exchange catalyzed by profilin. The Journal of Cell Biology. 150: 895-904. PMID 10953013 DOI: 10.1083/jcb.150.4.895  1
2000 Apgar J, Tseng Y, Fedorov E, Herwig MB, Almo SC, Wirtz D. Multiple-particle tracking measurements of heterogeneities in solutions of actin filaments and actin bundles Biophysical Journal. 79: 1095-1106. PMID 10920039  1
2000 Sarmiento M, Puius YA, Vetter SW, Keng YF, Wu L, Zhao Y, Lawrence DS, Almo SC, Zhang ZY. Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition. Biochemistry. 39: 8171-9. PMID 10889023 DOI: 10.1021/bi000319w  1
2000 Shi W, Munagala NR, Wang CC, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC. Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,). Biochemistry. 39: 6781-90. PMID 10841757 DOI: 10.1021/bi000128t  1
2000 Puius YA, Fedorov EV, Eichinger L, Schleicher M, Almo SC. Mapping the functional surface of domain 2 in the gelsolin superfamily. Biochemistry. 39: 5322-31. PMID 10820002 DOI: 10.1021/bi992364d  1
2000 Burke E, Mahoney NM, Almo SC, Barik S. Profilin is required for optimal actin-dependent transcription of respiratory syncytial virus genome RNA Journal of Virology. 74: 669-675. PMID 10623728 DOI: 10.1128/JVI.74.2.669-675.2000  1
2000 Mahoney NM, Rastogi VK, Cahill SM, Girvin ME, Almo SC. Binding orientation of proline-rich peptides in solution: Polarity of the profilin-ligand interaction [21] Journal of the American Chemical Society. 122: 7851-7852. DOI: 10.1021/ja001240h  1
1999 Levin S, Almo SC, Satir BH. Functional diversity of the phosphoglucomutase superfamily: structural implications. Protein Engineering. 12: 737-46. PMID 10506283  1
1999 Shi W, Li CM, Tyler PC, Furneaux RH, Cahill SM, Girvin ME, Grubmeyer C, Schramm VL, Almo SC. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Biochemistry. 38: 9872-80. PMID 10433693 DOI: 10.1021/bi990664p  1
1999 Shi W, Schramm VL, Almo SC. Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-Å crystal structure Journal of Biological Chemistry. 274: 21114-21120. PMID 10409664 DOI: 10.1074/jbc.274.30.21114  1
1999 Mahoney NM, Rozwarski DA, Fedorov E, Fedorov AA, Almo SC. Profilin binds proline-rich ligands in two distinct amide backbone orientations Nature Structural Biology. 6: 666-671. PMID 10404225 DOI: 10.1038/10722  1
1999 Fedorov AA, Fedorov E, Gertler F, Almo SC. Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function Nature Structural Biology. 6: 661-665. PMID 10404224 DOI: 10.1038/10717  1
1999 Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC. The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nature Structural Biology. 6: 588-93. PMID 10360366 DOI: 10.1038/9376  1
1998 Liu S, Fedorov AA, Pollard TD, Lattman EE, Almo SC, Magnus KA. Crystal packing induces a conformational change in profilin-I from Acanthamoeba castellanii Journal of Structural Biology. 123: 22-29. PMID 9774541 DOI: 10.1006/jsbi.1998.4009  1
1998 Patskovska LN, Fedorov AA, Patskovsky YV, Almo SC, Listowsky T. Expression, crystallization and preliminary X-ray analysis of ligand-free human glutathione S-transferase M2-2 Acta Crystallographica Section D: Biological Crystallography. 54: 458-460. PMID 9761928 DOI: 10.1107/S0907444997011190  1
1998 Mahoney NM, Almo SC. Crystallization and preliminary X-ray analysis of human platelet profilin complexed with an oligo proline peptide Acta Crystallographica Section D: Biological Crystallography. 54: 108-110. PMID 9761827 DOI: 10.1107/S0907444997008007  1
1998 Eads JC, Mahoney NM, Vorobiev S, Bresnick AR, Wen KK, Rubenstein PA, Haarer BK, Almo SC. Structure determination and characterization of Saccharomyces cerevisiae profilin. Biochemistry. 37: 11171-81. PMID 9698363 DOI: 10.1021/bi9720033  1
1998 Mitra J, Tang X, Almo SC, Shields D. Temperature-induced conformational changes in prosomatostatin-II: implications for processing. The Biochemical Journal. 334: 275-82. PMID 9693130  1
1998 Puius YA, Zou M, Ho NT, Ho C, Almo SC. Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp). Biochemistry. 37: 9258-65. PMID 9649306 DOI: 10.1021/bi9727287  1
1998 Mao C, Cook WJ, Zhou M, Federov AA, Almo SC, Ealick SE. Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues Biochemistry. 37: 7135-7146. PMID 9585525 DOI: 10.1021/bi9723919  1
1998 Degano M, Almo SC, Sacchettini JC, Schramm VL. Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor Biochemistry. 37: 6277-6285. PMID 9572842 DOI: 10.1021/bi973012e  1
1998 Puius YA, Mahoney NM, Almo SC. The modular structure of actin-regulatory proteins. Current Opinion in Cell Biology. 10: 23-34. PMID 9484592 DOI: 10.1016/S0955-0674(98)80083-5  1
1998 Mittermann I, Fetrow JS, Schaak DL, Almo SC, Kraft D, Heberle-Bors E, Valenta R. Oligomerization of profilins from birch, man and yeast. Profilin, a ligand for itself? Sexual Plant Reproduction. 11: 183-191. DOI: 10.1007/s004970050140  1
1997 Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC, Zhang ZY. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proceedings of the National Academy of Sciences of the United States of America. 94: 13420-5. PMID 9391040 DOI: 10.1073/pnas.94.25.13420  1
1997 Mahoney NM, Janmey PA, Almo SC. Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation Nature Structural Biology. 4: 953-960. PMID 9360613 DOI: 10.1038/nsb1197-953  1
1997 Lappalainen P, Fedorov EV, Fedorov AA, Almo SC, Drubin DG. Essential functions and actin-binding surfaces of yeast cofilin revealed by systematic mutagenesis. The Embo Journal. 16: 5520-30. PMID 9312011 DOI: 10.1093/emboj/16.18.5520  1
1997 Goldsmith SC, Pokala N, Shen W, Fedorov AA, Matsudaira P, Almo SC. The structure of an actin-crosslinking domain from human fimbrin Nature Structural Biology. 4: 708-712. PMID 9302997  1
1997 Goldsmith SC, Pokala N, Matsudaira P, Almo SC. Crystallization and preliminary crystallographic analysis of the N- terminal actin binding domain of human fimbrin Proteins: Structure, Function and Genetics. 28: 452-453. PMID 9223189 DOI: 10.1002/(SICI)1097-0134(199707)28:3<452::AID-PROT13>3.0.CO;2-G  1
1997 Fedorov AA, Lappalainen P, Fedorov EV, Drubin DG, Almo SC. Structure determination of yeast cofilin. Nature Structural Biology. 4: 366-9. PMID 9145106  1
1997 Fedorov AA, Ball T, Valenta R, Almo SC. X-ray crystal structures of birch pollen profilin and Phl p 2. International Archives of Allergy and Immunology. 113: 109-13. PMID 9130496  1
1997 Fedorov AA, Ball T, Mahoney NM, Valenta R, Almo SC. The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin. Structure (London, England : 1993). 5: 33-45. PMID 9016715  1
1997 Joseph-McCarthy D, Fedorov AA, Almo SC. Molecular Graphics, X-ray, NMR. Comparison of experimental and computational functional group mapping of an RNase A structure. Implication for computer aided drug design Quantitative Structure-Activity Relationships. 16: 350-354.  1
1997 Zhang ZY, Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC. Identification of a novel aryl phosphate-binding site in PTP1B: Implications for inhibitor design Faseb Journal. 11: A834.  1
1997 Zhan ZY, Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC. Identincation of a novel aryl phosphate-binding site in ptp1b: implications for inhibitor design Faseb Journal. 11: A1185.  1
1996 Fedorov AA, Joseph-McCarthy D, Fedorov E, Sirakova D, Graf I, Almo SC. Ionic interactions in crystalline bovine pancreatic ribonuclease A Biochemistry. 35: 15962-15979. PMID 8973167 DOI: 10.1021/bi961533g  1
1996 Joseph-McCarthy D, Fedorov AA, Almo SC. Comparison of experimental and computational functional group mapping of an RNase A structure: Implications for computer-aided drug design Protein Engineering. 9: 773-780. PMID 8888143  1
1994 Almo SC, Pollard TD, Way M, Lattman EE. Purification characterization and crystallization of Acanthamoeba profilin expressed in Escherichia coli Journal of Molecular Biology. 236: 950-952. PMID 8114104  1
1994 Fedorov AA, Magnus KA, Graupe MH, Lattman EE, Pollard TD, Almo SC. X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates Proceedings of the National Academy of Sciences of the United States of America. 91: 8636-8640. PMID 8078936  1
1994 Fedorov AA, Pollard TD, Almo SC. Purification, characterization and crystallization of human platelet profilin expressed in Escherichia coli Journal of Molecular Biology. 241: 480-482. PMID 8064860 DOI: 10.1006/jmbi.1994.1522  1
1994 Almo SC, Smith DL, Danishefsky AT, Ringe D. The structural basis for the altered substrate specificity of the r292d active site mutant of aspartate aminotransferase from E.coli Protein Engineering, Design and Selection. 7: 405-412. PMID 7909946 DOI: 10.1093/protein/7.3.405  1
1992 Howell PL, Almo SC, Parsons MR, Hajdu J, Petsko GA. Structure determination of turkey egg-white lysozyme using Laue diffraction data. Acta Crystallographica. Section B, Structural Science. 48: 200-7. PMID 1515108 DOI: 10.1107/S0108768191012466  1
1992 Howell PL, Almo SC, Parsons MR, Hajdu J, Petsko GA. Structure determination of turkey egg‐white lysozyme using Laue diffraction data Acta Crystallographica Section B. 48: 200-207. DOI: 10.1107/S0108768191012466  1
1989 Mondragón A, Subbiah S, Almo SC, Drottar M, Harrison SC. Structure of the amino-terminal domain of phage 434 repressor at 2.0 A resolution. Journal of Molecular Biology. 205: 189-200. PMID 2926803 DOI: 10.1016/0022-2836(89)90375-6  1
1989 Smith DL, Almo SC, Toney MD, Ringe D. 2.8-A-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli. Biochemistry. 28: 8161-7. PMID 2513875  1
1988 Farber GK, Machin P, Almo SC, Petsko GA, Hajdu J. X-ray Laue diffraction from crystals of xylose isomerase Proceedings of the National Academy of Sciences of the United States of America. 85: 112-115. PMID 3422408  1
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