Robert McKenna - Publications

Affiliations: 
Biochemistry and Molecular Biology University of Florida, Gainesville, Gainesville, FL, United States 
Website:
http://biochem.med.ufl.edu/research/primary-faculty/robert-mckenna/

174 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mboge MY, Chen Z, Khokhar D, Wolff A, Ai L, Heldermon CD, Bozdag M, Carta F, Supuran CT, Brown KD, McKenna R, Frost CJ, Frost SC. A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells. The Biochemical Journal. PMID 31072911 DOI: 10.1042/BCJ20190177  1
2019 Kurian JJ, Lakshmanan R, Chmely WM, Hull JA, Yu JC, Bennett A, McKenna R, Agbandje-McKenna M. Adeno-Associated Virus VP1u Exhibits Protease Activity. Viruses. 11. PMID 31035643 DOI: 10.3390/v11050399  1
2019 Andring J, Dohle W, Tu C, Potter BVL, McKenna R. 3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene (STX140) and Non-Steroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity. Journal of Medicinal Chemistry. PMID 30721041 DOI: 10.1021/acs.jmedchem.8b01990  1
2019 Koruza K, Mahon BP, Blakeley MP, Ostermann A, Schrader TE, McKenna R, Knecht W, Zoë Fisher S. Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative. Journal of Structural Biology. PMID 30639924 DOI: 10.1016/j.jsb.2018.12.009  1
2018 Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, Bozdag M, Carta F, Supuran CT, McKenna R, Frost SC. Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition. Plos One. 13: e0207417. PMID 30452451 DOI: 10.1371/journal.pone.0207417  1
2018 Forero-Quintero LS, Ames S, Schneider HP, Thyssen A, Boone CD, Andring JT, McKenna R, Casey JR, Deitmer JW, Becker HM. Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70. The Journal of Biological Chemistry. PMID 30446621 DOI: 10.1074/jbc.RA118.005536  1
2018 Nocentini A, Trallori E, Singh S, Lomelino CL, Bartolucci G, Di Cesare Mannelli L, Ghelardini C, McKenna R, Gratteri P, Supuran CT. 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles. Journal of Medicinal Chemistry. PMID 30433782 DOI: 10.1021/acs.jmedchem.8b01504  1
2018 Jose A, Mietzsch M, Smith K, Kurian J, Chipman P, McKenna R, Chiorini J, Agbandje-McKenna M. High resolution structural characterization of a new AAV5 antibody epitope toward engineering antibody resistant recombinant gene delivery vectors. Journal of Virology. PMID 30333169 DOI: 10.1128/JVI.01394-18  1
2018 Bennett A, Rodriguez D, Lister S, Boulton M, McKenna R, Agbandje-McKenna M. Assembly and disassembly intermediates of maize streak geminivirus. Virology. 525: 224-236. PMID 30300759 DOI: 10.1016/j.virol.2018.09.011  1
2018 Mahon BP, McKenna R. Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography. Methods in Molecular Biology (Clifton, N.J.). 1826: 9-39. PMID 30194591 DOI: 10.1007/978-1-4939-8645-3_2  1
2018 Tan YZ, Aiyer S, Mietzsch M, Hull JA, McKenna R, Grieger J, Samulski RJ, Baker TS, Agbandje-McKenna M, Lyumkis D. Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant. Nature Communications. 9: 3628. PMID 30194371 DOI: 10.1038/s41467-018-06076-6  1
2018 Mboge MY, Kota A, McKenna R, Frost SC. Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors. International Journal of Medicinal Chemistry. 2018: 2906519. PMID 30112206 DOI: 10.1155/2018/2906519  1
2018 Murray A, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R. Structural Mapping of Anion inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa. Chemmedchem. PMID 30088334 DOI: 10.1002/cmdc.201800375  1
2018 Lomelino CL, Murray AB, Supuran CT, McKenna R. Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. Acs Medicinal Chemistry Letters. 9: 657-661. PMID 30034596 DOI: 10.1021/acsmedchemlett.8b00100  1
2018 Chen Z, Ai L, Mboge MY, Tu C, McKenna R, Brown KD, Heldermon CD, Frost SC. Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells. Plos One. 13: e0199476. PMID 29965974 DOI: 10.1371/journal.pone.0199476  1
2018 Lomelino CL, Kim JK, Lee C, Lim SW, Andring JT, Mahon BP, Chung M, Kim CU, McKenna R. Carbonic anhydrase II microcrystals suitable for XFEL studies. Acta Crystallographica. Section F, Structural Biology Communications. 74: 327-330. PMID 29870015 DOI: 10.1107/S2053230X18006118  1
2018 Nocentini A, Ceruso M, Bua S, Lomelino CL, Andring J, McKenna R, Lanzi C, Sgambellone S, Pecori R, Matucci R, Filippi L, Gratteri P, Carta F, Masini E, Selleri S, et al. Discovery of β-adrenergic receptors blocker - carbonic anhydrase inhibitor hybrids for multitargeted anti-glaucoma therapy. Journal of Medicinal Chemistry. PMID 29851481 DOI: 10.1021/acs.jmedchem.8b00625  1
2018 Burg M, Rosebrough C, Drouin LM, Bennett A, Mietzsch M, Chipman P, McKenna R, Sousa D, Potter M, Byrne B, Jude Samulski R, Agbandje-McKenna M. Atomic structure of a rationally engineered gene delivery vector, AAV2.5. Journal of Structural Biology. PMID 29775653 DOI: 10.1016/j.jsb.2018.05.004  1
2018 Singh S, Lomelino CL, Mboge MY, Frost SC, McKenna R. Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site. Molecules (Basel, Switzerland). 23. PMID 29710858 DOI: 10.3390/molecules23051045  1
2018 Bennett AD, Wong K, Lewis J, Tseng YS, Smith JK, Chipman P, McKenna R, Samulski RJ, Kleinschmidt J, Agbandje-McKenna M. AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition. Virology. 518: 369-376. PMID 29604478 DOI: 10.1016/j.virol.2018.03.007  1
2018 Chen Z, Ai L, Mboge MY, McKenna R, Frost CJ, Heldermon CD, Frost SC. UFH-001 cells: A novel triple negative, CAIX-positive, human breast cancer model system. Cancer Biology & Therapy. 1-32. PMID 29561695 DOI: 10.1080/15384047.2018.1449612  1
2018 Mboge MY, Mahon BP, McKenna R, Frost SC. Carbonic Anhydrases: Role in pH Control and Cancer. Metabolites. 8. PMID 29495652 DOI: 10.3390/metabo8010019  1
2018 Kovalevsky A, Aggarwal M, Velazquez H, Cuneo MJ, Blakeley MP, Weiss KL, Smith JC, Fisher SZ, McKenna R. "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure (London, England : 1993). PMID 29429876 DOI: 10.1016/j.str.2018.01.006  1
2018 Bhatt A, Mondal UK, Supuran CT, Ilies MA, McKenna R. Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function. Molecular Neurobiology. PMID 29423818 DOI: 10.1007/s12035-017-0854-2  1
2018 Andring JT, Lomelino CL, Tu C, Silverman DN, McKenna R, Swenson ER. Carbonic Anhydrase II Does Not Exhibit Nitrate Reductase or Nitrous Anhydrase Activity. Free Radical Biology & Medicine. PMID 29355738 DOI: 10.1016/j.freeradbiomed.2018.01.015  1
2018 Kim JK, Lomelino CL, Avvaru BS, Mahon BP, McKenna R, Park S, Kim CU. Active-site solvent replenishment observed during human carbonic anhydrase II catalysis. Iucrj. 5: 93-102. PMID 29354275 DOI: 10.1107/S2052252517017626  1
2018 Ilyas M, Mietzsch M, Kailasan S, Väisänen E, Luo M, Chipman P, Smith JK, Kurian J, Sousa D, McKenna R, Söderlund-Venermo M, Agbandje-McKenna M. Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy. Viruses. 10. PMID 29300333 DOI: 10.3390/v10010022  1
2017 Murray AB, Lomelino CL, Supuran CT, McKenna R. "Seriously Sweet": Acesulfame K exhibits selective inhibition using alternative binding modes in carbonic anhydrase isoforms. Journal of Medicinal Chemistry. PMID 29266943 DOI: 10.1021/acs.jmedchem.7b01470  1
2017 Nocentini A, Bua S, Lomelino CL, McKenna R, Menicatti M, Bartolucci G, Tenci B, Di Cesare Mannelli L, Ghelardini C, Gratteri P, Supuran CT. Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. Acs Medicinal Chemistry Letters. 8: 1314-1319. PMID 29259754 DOI: 10.1021/acsmedchemlett.7b00399  1
2017 Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas A. Crystal Structure of Cleaved Serp-1, a Myxomavirus-derived Immune Modulating Serpin; Structural Design of Serpin Reactive Center Loop (RCL) Peptides with Improved Therapeutic Function. Biochemistry. PMID 29227673 DOI: 10.1021/acs.biochem.7b01171  1
2017 Pittman N, Misseldine A, Geilen L, Halder S, Smith JK, Kurian J, Chipman P, Janssen M, Mckenna R, Baker TS, D'Abramo A, Cotmore S, Tattersall P, Agbandje-McKenna M. Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. Viruses. 9. PMID 29084163 DOI: 10.3390/v9110321  1
2017 Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. Acs Medicinal Chemistry Letters. 8: 941-946. PMID 28947941 DOI: 10.1021/acsmedchemlett.7b00229  1
2017 Tran N, Kurian JJ, Bhatt A, McKenna R, Long JR. An Entropic Anomaly Observed in Lipid Polymorphisms Induced by Surfactant Peptide SP-B(1-25). The Journal of Physical Chemistry. B. PMID 28872861 DOI: 10.1021/acs.jpcb.7b06538  1
2017 Bennett A, Patel S, Mietzsch M, Jose A, Lins-Austin B, Yu JC, Bothner B, McKenna R, Agbandje-McKenna M. Thermal Stability as a Determinant of AAV Serotype Identity. Molecular Therapy. Methods & Clinical Development. 6: 171-182. PMID 28828392 DOI: 10.1016/j.omtm.2017.07.003  1
2017 Mboge MY, Mahon BP, Lamas N, Socorro L, Carta F, Supuran CT, Frost SC, McKenna R. Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides. European Journal of Medicinal Chemistry. 132: 184-191. PMID 28363153 DOI: 10.1016/j.ejmech.2017.03.026  1
2017 Mietzsch M, Kailasan S, Garrison J, Ilyas M, Chipman P, Kantola K, Janssen ME, Spear J, Sousa D, McKenna R, Brown K, Söderlund-Venermo M, Baker T, Agbandje-McKenna M. Structural insights into emerging pediatric pathogens human bocaparvoviruses. Journal of Virology. PMID 28331084 DOI: 10.1128/JVI.00261-17  1
2016 Aggarwal M, Kovalevsky AY, Velazquez H, Fisher SZ, Smith JC, McKenna R. Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug. Iucrj. 3: 319-325. PMID 28461893 DOI: 10.1107/S2052252516010514  1
2016 Callaway HM, Feng KH, Lee DW, Allison AB, Pinard M, McKenna R, Agbandje-McKenna M, Hafenstein S, Parrish CR. Parvovirus capsid structures required for infection: mutations controlling receptor recognition and protease cleavages. Journal of Virology. PMID 27847360 DOI: 10.1128/JVI.01871-16  1
2016 Liu Z, Huang X, Hu L, Pham L, Poole KM, Tang Y, Mahon BP, Tang W, Li K, Goldfarb NE, Dunn BM, McKenna R, Fanucci GE. Effects of Hinge Region Natural Polymorphisms on Human Immunodeficiency Virus-1 Protease Structure, Dynamics and Drug-Pressure Evolution. The Journal of Biological Chemistry. PMID 27576689 DOI: 10.1074/jbc.M116.747568  1
2016 Drouin LM, Lins B, Janssen M, Bennett A, Chipman P, McKenna R, Chen W, Muzyczka N, Cardone G, Baker TS, Agbandje-McKenna M. Cryo-electron microscopy reconstruction and stability studies of Wild-Type and R432A Variant of AAV2 Reveals Capsid Structural Stability is a Major Factor in Genome Packaging. Journal of Virology. PMID 27440903 DOI: 10.1128/JVI.00575-16  1
2016 Mahon BP, Bhatt A, Socorro L, Driscoll JM, Okoh C, Lomelino CL, Mboge MY, Kurian JJ, Tu C, Agbandje-McKenna M, Frost SC, McKenna R. Structure of carbonic anhydrase IX is adapted for low pH catalysis. Biochemistry. PMID 27439028 DOI: 10.1021/acs.biochem.6b00243  1
2016 Lomelino CL, Supuran CT, McKenna R. Non-Classical Inhibition of Carbonic Anhydrase. International Journal of Molecular Sciences. 17. PMID 27438828 DOI: 10.3390/ijms17071150  1
2016 Tseng YS, Vliet KV, Rao L, McKenna R, Byrne BJ, Asokan A, Agbandje-McKenna M. Generation and characterization of anti-AAV8 and anti-AAV9 monoclonal antibodies. Journal of Virological Methods. PMID 27424005 DOI: 10.1016/j.jviromet.2016.07.009  1
2016 Pinard MA, Kurian JJ, Aggarwal M, Agbandje-McKenna M, McKenna R. Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3. Acta Crystallographica. Section F, Structural Biology Communications. 72: 573-7. PMID 27380376 DOI: 10.1107/S2053230X16009286  0.01
2016 Kim CU, Song H, Avvaru BS, Gruner SM, Park S, McKenna R. Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114542 DOI: 10.1073/pnas.1520786113  1
2016 Tondnevis F, Weiss TM, Matsui T, Bloom LB, Mckenna R. Solution Structure of an "open" E. coli Pol III Clamp Loader Sliding Clamp Complex. Journal of Structural Biology. PMID 26968362 DOI: 10.1016/j.jsb.2016.03.003  1
2016 Huang LY, Patel A, Ng R, Miller EB, Halder S, McKenna R, Asokan A, Agbandje-McKenna M. Characterization of the Adeno-associated virus 1 and 6 sialic acid binding site. Journal of Virology. PMID 26962225 DOI: 10.1128/JVI.00161-16  1
2016 Kailasan S, Garrison J, Ilyas M, Chipman P, McKenna R, Kantola K, Söderlund-Venermo M, Kučinskaitė-Kodzė I, Žvirblienė A, Agbandje-McKenna M. Mapping Antigenic Epitopes on the Human Bocavirus Capsid. Journal of Virology. 90: 4670-80. PMID 26912619 DOI: 10.1128/JVI.02998-15  1
2016 Lomelino CL, Mahon BP, McKenna R, Carta F, Supuran CT. Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111. Bioorganic & Medicinal Chemistry. 24: 976-81. PMID 26810836 DOI: 10.1016/j.bmc.2016.01.019  1
2016 Vullo D, Bhatt A, Mahon BP, McKenna R, Supuran CT. Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorganic & Medicinal Chemistry Letters. 26: 401-405. PMID 26691758 DOI: 10.1016/j.bmcl.2015.11.104  1
2015 Mboge MY, McKenna R, Frost SC. Advances in Anti-Cancer Drug Development Targeting Carbonic Anhydrase IX and XII. Topics in Anti-Cancer Research. 5: 3-42. PMID 30272043  1
2015 Aggarwal M, McKenna R. Carbonic Anhydrases: Nature's Way to Balance CO2 Concentration. Biochemistry & Molecular Biology Journal. 1. PMID 28317035 DOI: 10.21767/2471-8084.100008  1
2015 Ambadapadi S, Munuswamy-Ramanujam G, Zheng D, Sullivan C, Dai E, Morshed S, McFadden B, Feldman E, Pinard M, McKenna R, Tibbetts S, Lucas A. Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities. The Journal of Biological Chemistry. PMID 26620556 DOI: 10.1074/jbc.M115.704841  1
2015 Aggarwal M, Chua TK, Pinard MA, Szebenyi DM, McKenna R. Carbon Dioxide "Trapped" in a β-Carbonic Anhydrase. Biochemistry. 54: 6631-8. PMID 26457866 DOI: 10.1021/acs.biochem.5b00987  1
2015 Pinard MA, Aggarwal M, Mahon BP, Tu C, McKenna R. A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1352-8. PMID 26457530 DOI: 10.1107/S2053230X1501239X  1
2015 Jamali S, Klier M, Ames S, Barros LF, McKenna R, Deitmer JW, Becker HM. Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function. Scientific Reports. 5: 13605. PMID 26337752 DOI: 10.1038/srep13605  1
2015 Halder S, Van Vliet K, Smith JK, Duong TT, McKenna R, Wilson JM, Agbandje-McKenna M. Structure of neurotropic adeno-associated virus AAVrh.8. Journal of Structural Biology. PMID 26334681 DOI: 10.1016/j.jsb.2015.08.017  1
2015 Mahon BP, Lomelino CL, Salguero AL, Driscoll JM, Pinard MA, McKenna R. Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli. Protein Science : a Publication of the Protein Society. 24: 1800-7. PMID 26266677 DOI: 10.1002/pro.2771  1
2015 Díaz-Torres NA, Mahon BP, Boone CD, Pinard MA, Tu C, Ng R, Agbandje-McKenna M, Silverman D, Scott K, McKenna R. Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration. Acta Crystallographica. Section D, Biological Crystallography. 71: 1745-56. PMID 26249355 DOI: 10.1107/S1399004715012183  1
2015 Mahon BP, Okoh CO, McKenna R. Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy? Future Oncology (London, England). 11: 2117-9. PMID 26235178 DOI: 10.2217/fon.15.137  1
2015 Mahon BP, Lomelino CL, Ladwig J, Rankin GM, Driscoll JM, Salguero AL, Pinard MA, Vullo D, Supuran CT, Poulsen SA, McKenna R. Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates. Journal of Medicinal Chemistry. 58: 6630-8. PMID 26203869 DOI: 10.1021/acs.jmedchem.5b00845  1
2015 Pinard MA, Lotlikar SR, Boone CD, Vullo D, Supuran CT, Patrauchan MA, McKenna R. Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry. PMID 26068018 DOI: 10.1016/j.bmc.2015.05.029  1
2015 Mahon BP, Díaz-Torres NA, Pinard MA, Tu C, Silverman DN, Scott KM, McKenna R. Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium. Bioorganic & Medicinal Chemistry Letters. PMID 25998503 DOI: 10.1016/j.bmcl.2015.05.001  1
2015 Michalczyk R, Unkefer CJ, Bacik JP, Schrader TE, Ostermann A, Kovalevsky AY, McKenna R, Fisher SZ. Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer. Proceedings of the National Academy of Sciences of the United States of America. 112: 5673-8. PMID 25902526 DOI: 10.1073/pnas.1502255112  1
2015 Pinard MA, Mahon B, McKenna R. Probing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitors. Biomed Research International. 2015: 453543. PMID 25811028 DOI: 10.1155/2015/453543  1
2015 Carta F, Di Cesare Mannelli L, Pinard M, Ghelardini C, Scozzafava A, McKenna R, Supuran CT. A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects. Bioorganic & Medicinal Chemistry. 23: 1828-40. PMID 25766630 DOI: 10.1016/j.bmc.2015.02.027  1
2015 Boone CD, Rasi V, Tu C, McKenna R. Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II. The Febs Journal. 282: 1445-57. PMID 25683338 DOI: 10.1111/febs.13232  1
2015 Mahon BP, Pinard MA, McKenna R. Targeting carbonic anhydrase IX activity and expression. Molecules (Basel, Switzerland). 20: 2323-48. PMID 25647573 DOI: 10.3390/molecules20022323  1
2015 Mahon BP, Hendon AM, Driscoll JM, Rankin GM, Poulsen SA, Supuran CT, McKenna R. Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors. Bioorganic & Medicinal Chemistry. 23: 849-54. PMID 25614109 DOI: 10.1016/j.bmc.2014.12.030  1
2015 Noor SI, Dietz S, Heidtmann H, Boone CD, McKenna R, Deitmer JW, Becker HM. Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II. The Journal of Biological Chemistry. 290: 4476-86. PMID 25561737 DOI: 10.1074/jbc.M114.624577  1
2015 Kailasan S, Halder S, Gurda B, Bladek H, Chipman PR, McKenna R, Brown K, Agbandje-McKenna M. Structure of an enteric pathogen, bovine parvovirus. Journal of Virology. 89: 2603-14. PMID 25520501 DOI: 10.1128/JVI.03157-14  1
2015 Goldfarb NE, Ohanessian M, Biswas S, McGee TD, Mahon BP, Ostrov DA, Garcia J, Tang Y, McKenna R, Roitberg A, Dunn BM. Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency. Biochemistry. 54: 422-33. PMID 25513833 DOI: 10.1021/bi501088e  1
2015 Tseng YS, Gurda BL, Chipman P, McKenna R, Afione S, Chiorini JA, Muzyczka N, Olson NH, Baker TS, Kleinschmidt J, Agbandje-McKenna M. Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity. Journal of Virology. 89: 1794-808. PMID 25410874 DOI: 10.1128/JVI.02710-14  1
2014 Wolmarans E, Sippel K, McKenna R, Joubert A. Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line. Cell & Bioscience. 4: 68. PMID 25937890 DOI: 10.1186/2045-3701-4-68  1
2014 Bozdag M, Pinard M, Carta F, Masini E, Scozzafava A, McKenna R, Supuran CT. A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects. Journal of Medicinal Chemistry. 57: 9673-86. PMID 25358036 DOI: 10.1021/jm501497m  1
2014 Heim KP, Crowley PJ, Long JR, Kailasan S, McKenna R, Brady LJ. An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1. Proceedings of the National Academy of Sciences of the United States of America. 111: 15746-51. PMID 25331888 DOI: 10.1073/pnas.1413018111  1
2014 West D, Pinard MA, Tu C, Silverman DN, McKenna R. Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest. Acta Crystallographica. Section F, Structural Biology Communications. 70: 1324-7. PMID 25286933 DOI: 10.1107/S2053230X14018135  1
2014 Moeker J, Mahon BP, Bornaghi LF, Vullo D, Supuran CT, McKenna R, Poulsen SA. Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates. Journal of Medicinal Chemistry. 57: 8635-45. PMID 25254302 DOI: 10.1021/jm5012935  1
2014 Pala N, Micheletto L, Sechi M, Aggarwal M, Carta F, McKenna R, Supuran CT. Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry. Acs Medicinal Chemistry Letters. 5: 927-30. PMID 25147616 DOI: 10.1021/ml500196t  1
2014 Aggarwal M, Kondeti B, Tu C, Maupin CM, Silverman DN, McKenna R. Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. Iucrj. 1: 129-35. PMID 25075329 DOI: 10.1107/S2052252514004096  1
2014 Ogram SA, Boone CD, McKenna R, Flanegan JB. Amiloride inhibits the initiation of Coxsackievirus and poliovirus RNA replication by inhibiting VPg uridylylation. Virology. 464: 87-97. PMID 25058507 DOI: 10.1016/j.virol.2014.06.025  1
2014 Mohandas R, Sautina L, Beem E, Schuler A, Chan WY, Domsic J, McKenna R, Johnson RJ, Segal MS. Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret. Experimental Cell Research. 326: 136-42. PMID 24925478 DOI: 10.1016/j.yexcr.2014.05.025  1
2014 Boone CD, Tu C, McKenna R. Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II. Acta Crystallographica. Section D, Biological Crystallography. 70: 1758-63. PMID 24914985 DOI: 10.1107/S1399004714007457  1
2014 Huang X, Britto MD, Kear-Scott JL, Boone CD, Rocca JR, Simmerling C, Mckenna R, Bieri M, Gooley PR, Dunn BM, Fanucci GE. The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics. The Journal of Biological Chemistry. 289: 17203-14. PMID 24742668 DOI: 10.1074/jbc.M114.571836  1
2014 Mikals K, Nam HJ, Van Vliet K, Vandenberghe LH, Mays LE, McKenna R, Wilson JM, Agbandje-McKenna M. The structure of AAVrh32.33, a novel gene delivery vector. Journal of Structural Biology. 186: 308-17. PMID 24704217 DOI: 10.1016/j.jsb.2014.03.020  1
2014 Boone CD, Zhong G, Smeltz M, James MO, McKenna R. Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a). Acta Crystallographica. Section F, Structural Biology Communications. 70: 187-9. PMID 24637752 DOI: 10.1107/S2053230X13033591  1
2014 Wolmarans E, Mqoco TV, Stander A, Nkandeu SD, Sippel K, McKenna R, Joubert A. Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells. Cellular & Molecular Biology Letters. 19: 98-115. PMID 24563014 DOI: 10.2478/s11658-014-0183-7  1
2014 Halder S, Cotmore S, Heimburg-Molinaro J, Smith DF, Cummings RD, Chen X, Trollope AJ, North SJ, Haslam SM, Dell A, Tattersall P, McKenna R, Agbandje-McKenna M. Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition. Plos One. 9: e86909. PMID 24475195 DOI: 10.1371/journal.pone.0086909  1
2014 Salganik M, Aydemir F, Nam HJ, McKenna R, Agbandje-McKenna M, Muzyczka N. Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes. Journal of Virology. 88: 1071-9. PMID 24198419 DOI: 10.1128/JVI.02093-13  1
2014 McKenna R, Supuran CT. Carbonic anhydrase inhibitors drug design. Sub-Cellular Biochemistry. 75: 291-323. PMID 24146385 DOI: 10.1007/978-94-007-7359-2_15  1
2014 Boone CD, Pinard M, McKenna R, Silverman D. Catalytic mechanism of α-class carbonic anhydrases: CO2 hydration and proton transfer. Sub-Cellular Biochemistry. 75: 31-52. PMID 24146373 DOI: 10.1007/978-94-007-7359-2_3  1
2014 McKenna R, Frost SC. Overview of the carbonic anhydrase family. Sub-Cellular Biochemistry. 75: 3-5. PMID 24146371 DOI: 10.1007/978-94-007-7359-2_1  1
2013 Boone CD, Habibzadegan A, Gill S, McKenna R. Carbonic anhydrases and their biotechnological applications. Biomolecules. 3: 553-62. PMID 24970180 DOI: 10.3390/biom3030553  1
2013 Pinard MA, Boone CD, Rife BD, Supuran CT, McKenna R. Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorganic & Medicinal Chemistry. 21: 7210-5. PMID 24090602 DOI: 10.1016/j.bmc.2013.08.033  1
2013 Rayaprolu V, Kruse S, Kant R, Venkatakrishnan B, Movahed N, Brooke D, Lins B, Bennett A, Potter T, McKenna R, Agbandje-McKenna M, Bothner B. Comparative analysis of adeno-associated virus capsid stability and dynamics. Journal of Virology. 87: 13150-60. PMID 24067976 DOI: 10.1128/JVI.01415-13  1
2013 Boone CD, Gill S, Tu C, Silverman DN, McKenna R. Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II. Archives of Biochemistry and Biophysics. 539: 31-7. PMID 24036123 DOI: 10.1016/j.abb.2013.09.001  1
2013 Güzel-Akdemir O, Biswas S, Lastra K, McKenna R, Supuran CT. Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry. 21: 6674-80. PMID 24012377 DOI: 10.1016/j.bmc.2013.08.011  1
2013 Biswas S, McKenna R, Supuran CT. Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry Letters. 23: 5646-9. PMID 23993330 DOI: 10.1016/j.bmcl.2013.08.019  1
2013 Tang M, Shen H, Jin Y, Lin T, Cai Q, Pinard MA, Biswas S, Tran Q, Li G, Shenoy AK, Tongdee E, Lin S, Gu Y, Law BK, Zhou L, ... McKenna R, et al. The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition. The Journal of Biological Chemistry. 288: 27680-91. PMID 23928305 DOI: 10.1074/jbc.M113.482349  1
2013 Govindasamy L, DiMattia MA, Gurda BL, Halder S, McKenna R, Chiorini JA, Muzyczka N, Zolotukhin S, Agbandje-McKenna M. Structural insights into adeno-associated virus serotype 5. Journal of Virology. 87: 11187-99. PMID 23926356 DOI: 10.1128/JVI.00867-13  1
2013 Pinard M, Lotlikar S, Patrauchan MA, McKenna R. Preliminary X-ray crystallographic analysis of β-carbonic anhydrase psCA3 from Pseudomonas aeruginosa. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 891-4. PMID 23908036 DOI: 10.1107/S1744309113017594  1
2013 Boone CD, Habibzadegan A, Tu C, Silverman DN, McKenna R. Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond. Acta Crystallographica. Section D, Biological Crystallography. 69: 1414-22. PMID 23897465 DOI: 10.1107/S0907444913008743  1
2013 Gurda BL, DiMattia MA, Miller EB, Bennett A, McKenna R, Weichert WS, Nelson CD, Chen WJ, Muzyczka N, Olson NH, Sinkovits RS, Chiorini JA, Zolotutkhin S, Kozyreva OG, Samulski RJ, et al. Capsid antibodies to different adeno-associated virus serotypes bind common regions. Journal of Virology. 87: 9111-24. PMID 23760240 DOI: 10.1128/JVI.00622-13  1
2013 Aggarwal M, Boone CD, Kondeti B, Tu C, Silverman DN, McKenna R. Effects of cryoprotectants on the structure and thermostability of the human carbonic anhydrase II-acetazolamide complex. Acta Crystallographica. Section D, Biological Crystallography. 69: 860-5. PMID 23633596 DOI: 10.1107/S0907444913002771  1
2013 Aggarwal M, Kondeti B, McKenna R. Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review. Expert Opinion On Therapeutic Patents. 23: 717-24. PMID 23514045 DOI: 10.1517/13543776.2013.782394  1
2013 Biswas S, Carta F, Scozzafava A, McKenna R, Supuran CT. Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry. 21: 2314-8. PMID 23490152 DOI: 10.1016/j.bmc.2013.02.022  1
2013 Kay NE, Bainbridge TW, Condit RC, Bubb MR, Judd RE, Venkatakrishnan B, McKenna R, D'Costa SM. Biochemical and biophysical properties of a putative hub protein expressed by vaccinia virus. The Journal of Biological Chemistry. 288: 11470-81. PMID 23476017 DOI: 10.1074/jbc.M112.442012  1
2013 Halder S, Nam HJ, Govindasamy L, Vogel M, Dinsart C, Salomé N, McKenna R, Agbandje-McKenna M. Structural characterization of H-1 parvovirus: comparison of infectious virions to empty capsids. Journal of Virology. 87: 5128-40. PMID 23449783 DOI: 10.1128/JVI.03416-12  1
2013 Venkatakrishnan B, Yarbrough J, Domsic J, Bennett A, Bothner B, Kozyreva OG, Samulski RJ, Muzyczka N, McKenna R, Agbandje-McKenna M. Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking. Journal of Virology. 87: 4974-84. PMID 23427155 DOI: 10.1128/JVI.02524-12  1
2013 Stander BA, Joubert F, Tu C, Sippel KH, McKenna R, Joubert AM. Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells. Plos One. 8: e53853. PMID 23382857 DOI: 10.1371/journal.pone.0053853  1
2013 Mikulski R, West D, Sippel KH, Avvaru BS, Aggarwal M, Tu C, McKenna R, Silverman DN. Water networks in fast proton transfer during catalysis by human carbonic anhydrase II. Biochemistry. 52: 125-31. PMID 23215152 DOI: 10.1021/bi301099k  1
2013 Aggarwal M, Boone CD, Kondeti B, McKenna R. Structural annotation of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry. 28: 267-77. PMID 23137351 DOI: 10.3109/14756366.2012.737323  1
2013 Zimmerman S, Domsic JF, Tu C, Robbins AH, McKenna R, Silverman DN, Ferry JG. Role of Trp19 and Tyr200 in catalysis by the γ-class carbonic anhydrase from Methanosarcina thermophila. Archives of Biochemistry and Biophysics. 529: 11-7. PMID 23111186 DOI: 10.1016/j.abb.2012.10.010  1
2013 Aggarwal M, Kondeti B, McKenna R. Insights towards sulfonamide drug specificity in α-carbonic anhydrases. Bioorganic & Medicinal Chemistry. 21: 1526-33. PMID 22985956 DOI: 10.1016/j.bmc.2012.08.019  1
2012 Stander BA, Joubert F, Tu C, Sippel KH, McKenna R, Joubert AM. In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity. Plos One. 7: e52205. PMID 23300615 DOI: 10.1371/journal.pone.0052205  1
2012 Halder S, Nam HJ, Govindasamy L, Vogel M, Dinsart C, Salomé N, McKenna R, Agbandje-McKenna M. Production, purification, crystallization and structure determination of H-1 Parvovirus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 1571-6. PMID 23192051 DOI: 10.1107/S1744309112045563  1
2012 West D, Kim CU, Tu C, Robbins AH, Gruner SM, Silverman DN, McKenna R. Structural and kinetic effects on changes in the CO(2) binding pocket of human carbonic anhydrase II. Biochemistry. 51: 9156-63. PMID 23098192 DOI: 10.1021/bi301155z  1
2012 Marini AM, Maresca A, Aggarwal M, Orlandini E, Nencetti S, Da Settimo F, Salerno S, Simorini F, La Motta C, Taliani S, Nuti E, Scozzafava A, McKenna R, Rossello A, Supuran CT. Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms. Journal of Medicinal Chemistry. 55: 9619-29. PMID 23067387 DOI: 10.1021/jm300878g  1
2012 Díaz Torres N, González G, Biswas S, Scott KM, McKenna R. Preliminary X-ray crystallographic analysis of α-carbonic anhydrase from Thiomicrospira crunogena XCL-2. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 1064-6. PMID 22949195 DOI: 10.1107/S1744309112031053  1
2012 Fisher SZ, Aggarwal M, Kovalevsky AY, Silverman DN, McKenna R. Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding. Journal of the American Chemical Society. 134: 14726-9. PMID 22928733 DOI: 10.1021/ja3068098  1
2012 Salganik M, Venkatakrishnan B, Bennett A, Lins B, Yarbrough J, Muzyczka N, Agbandje-McKenna M, McKenna R. Evidence for pH-dependent protease activity in the adeno-associated virus capsid. Journal of Virology. 86: 11877-85. PMID 22915820 DOI: 10.1128/JVI.01717-12  1
2012 Aggarwal M, McKenna R. Update on carbonic anhydrase inhibitors: a patent review (2008 - 2011). Expert Opinion On Therapeutic Patents. 22: 903-15. PMID 22788994 DOI: 10.1517/13543776.2012.707646  1
2012 Fisher Z, Boone CD, Biswas SM, Venkatakrishnan B, Aggarwal M, Tu C, Agbandje-McKenna M, Silverman D, McKenna R. Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Engineering, Design & Selection : Peds. 25: 347-55. PMID 22691706 DOI: 10.1093/protein/gzs027  1
2012 Gurda BL, Raupp C, Popa-Wagner R, Naumer M, Olson NH, Ng R, McKenna R, Baker TS, Kleinschmidt JA, Agbandje-McKenna M. Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. Journal of Virology. 86: 7739-51. PMID 22593150 DOI: 10.1128/JVI.00218-12  1
2012 Venkatakrishnan B, Palii ML, Agbandje-McKenna M, McKenna R. Mining the protein data bank to differentiate error from structural variation in clustered static structures: an examination of HIV protease. Viruses. 4: 348-62. PMID 22590675 DOI: 10.3390/v4030348  1
2012 Stridh MH, Alt MD, Wittmann S, Heidtmann H, Aggarwal M, Riederer B, Seidler U, Wennemuth G, McKenna R, Deitmer JW, Becker HM. Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II. The Journal of Physiology. 590: 2333-51. PMID 22451434 DOI: 10.1113/jphysiol.2011.220152  1
2012 Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Masini E, Supuran CT. Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo. Journal of Medicinal Chemistry. 55: 1721-30. PMID 22276570 DOI: 10.1021/jm300031j  1
2012 Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Supuran CT. Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. Chemical Communications (Cambridge, England). 48: 1868-70. PMID 22218610 DOI: 10.1039/c2cc16395k  1
2011 Mikulski R, Domsic JF, Ling G, Tu C, Robbins AH, Silverman DN, McKenna R. Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5. Archives of Biochemistry and Biophysics. 516: 97-102. PMID 22001224 DOI: 10.1016/j.abb.2011.09.011  1
2011 Biswas S, Aggarwal M, Güzel Ö, Scozzafava A, McKenna R, Supuran CT. Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms. Bioorganic & Medicinal Chemistry. 19: 3732-8. PMID 21620713 DOI: 10.1016/j.bmc.2011.05.006  1
2011 Carta F, Garaj V, Maresca A, Wagner J, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT. Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry. 19: 3105-19. PMID 21515057 DOI: 10.1016/j.bmc.2011.04.005  1
2011 Hen N, Bialer M, Yagen B, Maresca A, Aggarwal M, Robbins AH, McKenna R, Scozzafava A, Supuran CT. Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV. Journal of Medicinal Chemistry. 54: 3977-81. PMID 21506569 DOI: 10.1021/jm200209n  1
2011 Mikulski R, Avvaru BS, Tu C, Case N, McKenna R, Silverman DN. Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II. Archives of Biochemistry and Biophysics. 506: 181-7. PMID 21145876 DOI: 10.1016/j.abb.2010.12.004  1
2011 Sippel KH, Venkatakrishnan B, Boehlein SK, Sankaran B, Quirit JG, Govindasamy L, Agbandje-McKenna M, Goodison S, Rosser CJ, McKenna R. Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein. Proteins. 79: 528-36. PMID 21117240 DOI: 10.1002/prot.22900  1
2010 Sippel KH, Genis C, Govindasamy L, Agbandje-McKenna M, Kiddle JJ, Tripp BC, McKenna R. Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II. The Journal of Physical Chemistry Letters. 1: 2898-2902. PMID 20976122 DOI: 10.1021/jz100954h  1
2010 Pacchiano F, Aggarwal M, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT. Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency. Chemical Communications (Cambridge, England). 46: 8371-3. PMID 20922253 DOI: 10.1039/c0cc02707c  1
2010 Robbins AH, Domsic JF, Agbandje-McKenna M, McKenna R. Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis. Acta Crystallographica. Section D, Biological Crystallography. 66: 950-2. PMID 20693695 DOI: 10.1107/S0907444910023723  1
2010 Avvaru BS, Arenas DJ, Tu C, Tanner DB, McKenna R, Silverman DN. Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II. Archives of Biochemistry and Biophysics. 502: 53-9. PMID 20637176 DOI: 10.1016/j.abb.2010.07.010  1
2010 Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R. Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 4376-81. PMID 20605094 DOI: 10.1016/j.bmcl.2010.06.082  1
2010 Wagner J, Avvaru BS, Robbins AH, Scozzafava A, Supuran CT, McKenna R. Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations. Bioorganic & Medicinal Chemistry. 18: 4873-8. PMID 20598552 DOI: 10.1016/j.bmc.2010.06.028  1
2010 Domsic JF, Williams W, Fisher SZ, Tu C, Agbandje-McKenna M, Silverman DN, McKenna R. Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry. 49: 6394-9. PMID 20578724 DOI: 10.1021/bi1007645  1
2010 Robbins AH, Domsic JF, Agbandje-McKenna M, McKenna R. Structure of a monoclinic polymorph of human carbonic anhydrase II with a doubled a axis. Acta Crystallographica. Section D, Biological Crystallography. 66: 628-34. PMID 20445238 DOI: 10.1107/S0907444910006797  1
2010 Fisher SZ, Kovalevsky AY, Domsic JF, Mustyakimov M, McKenna R, Silverman DN, Langan PA. Neutron structure of human carbonic anhydrase II: implications for proton transfer. Biochemistry. 49: 415-21. PMID 20025241 DOI: 10.1021/bi901995n  1
2010 Avvaru BS, Kim CU, Sippel KH, Gruner SM, Agbandje-McKenna M, Silverman DN, McKenna R. A short, strong hydrogen bond in the active site of human carbonic anhydrase II. Biochemistry. 49: 249-51. PMID 20000378 DOI: 10.1021/bi902007b  1
2010 Domsic JF, McKenna R. Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases. Biochimica Et Biophysica Acta. 1804: 326-31. PMID 19679198 DOI: 10.1016/j.bbapap.2009.07.025  1
2009 Sippel KH, Robbins AH, Domsic J, Genis C, Agbandje-McKenna M, McKenna R. High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 992-5. PMID 19851004 DOI: 10.1107/S1744309109036665  1
2009 Sippel KH, Boehlein SK, Sakai Y, Quirit JG, Agbandje-McKenna M, Rosser CJ, McKenna R. Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 910-2. PMID 19724130 DOI: 10.1107/S1744309109030565  1
2009 Avvaru BS, Busby SA, Chalmers MJ, Griffin PR, Venkatakrishnan B, Agbandje-McKenna M, Silverman DN, McKenna R. Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. Biochemistry. 48: 7365-72. PMID 19583303 DOI: 10.1021/bi9007512  1
2009 Sippel KH, Robbins AH, Reutzel R, Boehlein SK, Namiki K, Goodison S, Agbandje-McKenna M, Rosser CJ, McKenna R. Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis. Journal of Bacteriology. 191: 2585-92. PMID 19233924 DOI: 10.1128/JB.01680-08  1
2009 Genis C, Sippel KH, Case N, Cao W, Avvaru BS, Tartaglia LJ, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Rosser CJ, McKenna R. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry. 48: 1322-31. PMID 19170619 DOI: 10.1021/bi802035f  1
2008 Sippel KH, Robbins AH, Reutzel R, Domsic J, Boehlein SK, Govindasamy L, Agbandje-McKenna M, Rosser CJ, McKenna R. Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37. Acta Crystallographica. Section D, Biological Crystallography. 64: 1172-8. PMID 19020356 DOI: 10.1107/S0907444908030175  1
2008 Zheng J, Avvaru BS, Tu C, McKenna R, Silverman DN. Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II. Biochemistry. 47: 12028-36. PMID 18942852 DOI: 10.1021/bi801473w  1
2008 Domsic JF, Avvaru BS, Kim CU, Gruner SM, Agbandje-McKenna M, Silverman DN, McKenna R. Entrapment of carbon dioxide in the active site of carbonic anhydrase II. The Journal of Biological Chemistry. 283: 30766-71. PMID 18768466 DOI: 10.1074/jbc.M805353200  1
2008 Quint PS, Domsic JF, Cabelli DE, McKenna R, Silverman DN. Role of a glutamate bridge spanning the dimeric interface of human manganese superoxide dismutase. Biochemistry. 47: 4621-8. PMID 18373354 DOI: 10.1021/bi7024518  1
2008 Barrese AA, Genis C, Fisher SZ, Orwenyo JN, Kumara MT, Dutta SK, Phillips E, Kiddle JJ, Tu C, Silverman DN, Govindasamy L, Agbandje-McKenna M, McKenna R, Tripp BC. Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry. 47: 3174-84. PMID 18266323 DOI: 10.1021/bi702385k  1
2007 Zheng J, Domsic JF, Cabelli D, McKenna R, Silverman DN. Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases. Biochemistry. 46: 14830-7. PMID 18044968 DOI: 10.1021/bi7014103  1
2007 Sabo-Attwood T, Blum JL, Kroll KJ, Patel V, Birkholz D, Szabo NJ, Fisher SZ, McKenna R, Campbell-Thompson M, Denslow ND. Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol. Journal of Molecular Endocrinology. 39: 223-37. PMID 17909263 DOI: 10.1677/JME-07-0038  1
2007 Fisher SZ, Tu C, Bhatt D, Govindasamy L, Agbandje-McKenna M, McKenna R, Silverman DN. Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II. Biochemistry. 46: 3803-13. PMID 17330962 DOI: 10.1021/bi602620k  1
2007 Bhatt D, Fisher SZ, Tu C, McKenna R, Silverman DN. Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophysical Journal. 92: 562-70. PMID 17071654 DOI: 10.1529/biophysj.106.093203  1
2006 Fisher SZ, Tariku I, Case NM, Tu C, Seron T, Silverman DN, Linser PJ, McKenna R. Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1). Biochimica Et Biophysica Acta. 1764: 1413-9. PMID 16920039 DOI: 10.1016/j.bbapap.2006.06.013  1
2006 Fisher SZ, Govindasamy L, Boyle N, Agbandje-McKenna M, Silverman DN, Blackburn GM, McKenna R. X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 618-22. PMID 16820676 DOI: 10.1107/S1744309106020446  1
2006 Budayova-Spano M, Fisher SZ, Dauvergne MT, Agbandje-McKenna M, Silverman DN, Myles DA, McKenna R. Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 6-9. PMID 16511248 DOI: 10.1107/S1744309105038248  1
2006 Clemente JC, Govindasamy L, Madabushi A, Fisher SZ, Moose RE, Yowell CA, Hidaka K, Kimura T, Hayashi Y, Kiso Y, Agbandje-McKenna M, Dame JB, Dunn BM, McKenna R. Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. Acta Crystallographica. Section D, Biological Crystallography. 62: 246-52. PMID 16510971 DOI: 10.1107/S0907444905041260  1
2005 Madabushi A, Chakraborty S, Fisher SZ, Clemente JC, Yowell C, Agbandje-McKenna M, Dame JB, Dunn BM, McKenna R. Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 228-31. PMID 16511002 DOI: 10.1107/S1744309105001405  1
2005 Bhatt D, Tu C, Fisher SZ, Hernandez Prada JA, McKenna R, Silverman DN. Proton transfer in a Thr200His mutant of human carbonic anhydrase II. Proteins. 61: 239-45. PMID 16106378 DOI: 10.1002/prot.20615  1
2005 Duda DM, Tu C, Fisher SZ, An H, Yoshioka C, Govindasamy L, Laipis PJ, Agbandje-McKenna M, Silverman DN, McKenna R. Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer. Biochemistry. 44: 10046-53. PMID 16042381 DOI: 10.1021/bi050610h  1
2002 Duda DM, Yoshioka C, Govindasamy L, An H, Tu C, Silverman DN, McKenna R. Crystallization and preliminary X-ray analysis of human carbonic anhydrase III. Acta Crystallographica. Section D, Biological Crystallography. 58: 849-52. PMID 11976500  1
2000 Bennett M, Krah A, Wien F, Garman E, McKenna R, Sanderson M, Neidle S. A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling. Proceedings of the National Academy of Sciences of the United States of America. 97: 9476-81. PMID 10920199 DOI: 10.1073/pnas.160271897  1
1992 Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. Journal of Medicinal Chemistry. 35: 1418-29. PMID 1573635  1
1991 McKenna R, Neidle S, Wilson WD. Structures of 1-(3,3-dimethylamino)propyl naphtho[2,1-b]thiophene-4- carboxylate and N-(3,3-dimethylamino)propyl-8-methoxynaphtho[2,1- b]thiophene-4-carboxamide, intercalators into double-helical DNA. Acta Crystallographica. Section C, Crystal Structure Communications. 47: 2511-3. PMID 1805872  1
1990 Laughton CA, McKenna R, Neidle S, Jarman M, McCague R, Rowlands MG. Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives. Journal of Medicinal Chemistry. 33: 2673-9. PMID 2391706  1
1989 McKenna R, Beveridge AJ, Jenkins TC, Neidle S, Denny WA. Molecular modelling of DNA-antitumour drug intercalation interactions: correlation of structural and energetic features with biological properties for a series of phenylquinoline-8-carboxamide compounds. Molecular Pharmacology. 35: 720-8. PMID 2725476  1
1989 McKenna R, Neidle S, Kuroda R, Fox BW. Structures of three DNA cross-linking agents, ethane-1,2-di(methylsulfonate), propane-1,3-di(methylsulfonate) and n-butane-1,4-di(methylsulfonate). Acta Crystallographica. Section C, Crystal Structure Communications. 45: 311-4. PMID 2558689  1
1988 McKenna R, Jenkins TC, Neidle S. Structures of the anticancer compounds N-(2-hydroxyethyl)-2-(3-nitro-1,2,4-triazol-1-yl)-acetamide (RB-6110) and 5-(1-aziridinyl)-3-nitro-1-(3-oxo-1-butyl)-1,2,4- triazole (RB-6162). Acta Crystallographica. Section B, Structural Science. 44: 672-6. PMID 3271560  1
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