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Robert McKenna - Publications

Affiliations: 
Biochemistry and Molecular Biology University of Florida, Gainesville, Gainesville, FL, United States 
Website:
http://biochem.med.ufl.edu/research/primary-faculty/robert-mckenna/
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297 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Li L, Qin R, Liu Y, Tseng YS, Zhang W, Yu L, Mietzsch M, Zou X, Liu H, Lu G, Hu H, Mckenna R, Yang J, Wei Y, Agbandje-Mckenna M, et al. Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages. Plos Pathogens. 20: e1012260. PMID 38885242 DOI: 10.1371/journal.ppat.1012260  0.48
2024 Lakshmanan RV, Agbandje-McKenna M, McKenna R. Feasibility of Domain Segmentation of B19V VP1u Using Intein Technology for Structural Studies. Protein and Peptide Letters. PMID 38243925 DOI: 10.2174/0109298665277211231214065419  0.478
2024 Aiyer S, Baldwin PR, Tan SM, Shan Z, Oh J, Mehrani A, Bowman ME, Louie G, Passos DO, Đorđević-Marquardt S, Mietzsch M, Hull JA, Hoshika S, Barad BA, Grotjahn DA, ... McKenna R, et al. Overcoming resolution attenuation during tilted cryo-EM data collection. Nature Communications. 15: 389. PMID 38195598 DOI: 10.1038/s41467-023-44555-7  0.472
2023 Aiyer S, Baldwin PR, Tan SM, Shan Z, Oh J, Mehrani A, Bowman ME, Louie G, Passos DO, Đorđević-Marquardt S, Mietzsch M, Hull JA, Hoshika S, Barad BA, Grotjahn DA, ... McKenna R, et al. Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection. Biorxiv : the Preprint Server For Biology. PMID 37503021 DOI: 10.1101/2023.07.14.548955  0.466
2023 Bennett A, Gargas J, Kansol A, Lewis J, Hsi J, Hull J, Mietzsch M, Tartaglia L, Muzyczka N, Bhattacharya N, Chipman P, Agbandje-McKenna M, McKenna R. Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants. Journal of Virology. e0177222. PMID 37310260 DOI: 10.1128/jvi.01772-22  0.501
2022 Lakshmanan RV, Hull JA, Berry L, Burg M, Bothner B, McKenna R, Agbandje-McKenna M. Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking. Viruses. 14. PMID 36146728 DOI: 10.3390/v14091922  0.473
2022 El Andari J, Renaud-Gabardos E, Tulalamba W, Weinmann J, Mangin L, Pham QH, Hille S, Bennett A, Attebi E, Bourges E, Leborgne C, Guerchet N, Fakhiri J, Krämer C, Wiedtke E, ... McKenna R, et al. Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders. Science Advances. 8: eabn4704. PMID 36129972 DOI: 10.1126/sciadv.abn4704  0.421
2022 Mietzsch M, Hull JA, Makal VE, Jimenez Ybargollin A, Yu JC, McKissock K, Bennett A, Penzes J, Lins-Austin B, Yu Q, Chipman P, Bhattacharya N, Sousa D, Strugatsky D, Tijssen P, ... McKenna R, et al. Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity. Journal of Virology. e0033522. PMID 35532224 DOI: 10.1128/jvi.00335-22  0.514
2021 Emmanuel SN, Smith JK, Hsi J, Tseng YS, Kaplan M, Mietzsch M, Chipman P, Asokan A, McKenna R, Agbandje-McKenna M. Structurally Mapping Antigenic Epitopes of Adeno-Associated Virus 9: Development of Antibody Escape Variants. Journal of Virology. JVI0125121. PMID 34757842 DOI: 10.1128/JVI.01251-21  0.461
2021 Mietzsch M, Yu JC, Hsi J, Chipman P, Broecker F, Fuming Z, Linhardt RJ, Seeberger PH, Heilbronn R, McKenna R, Agbandje-McKenna M. Structural study of AAVrh.10 Receptor and Antibody Interactions. Journal of Virology. JVI0124921. PMID 34549984 DOI: 10.1128/JVI.01249-21  0.501
2021 Bennett A, Hull J, Jolinon N, Tordo J, Moss K, Binns E, Mietzsch M, Hagemann C, Michael Linden R, Serio A, Chipman P, Sousa D, Broecker F, Seeberger P, Henckaerts E, ... McKenna R, et al. Comparative Structural, Biophysical, and Receptor Binding Study of True Type and Wild type AAV2. Journal of Structural Biology. 107795. PMID 34509611 DOI: 10.1016/j.jsb.2021.107795  0.532
2021 Mietzsch M, Eddington C, Jose A, Hsi J, Chipman P, Henley T, Choudhry M, McKenna R, Agbandje-McKenna M. Improved Genome Packaging Efficiency of AAV Vectors Using Rep Hybrids. Journal of Virology. JVI0077321. PMID 34287038 DOI: 10.1128/JVI.00773-21  0.443
2021 Penzes JJ, Chipman P, Bhattacharya N, Zeher A, Huang R, McKenna R, Agbandje-McKenna M. AAV9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment. Journal of Virology. JVI0084321. PMID 34260280 DOI: 10.1128/JVI.00843-21  0.511
2021 Havlik LP, Das A, Mietzsch M, Oh DK, Ark J, McKenna R, Agbandje-McKenna M, Asokan A. Receptor switching in newly evolved adeno-associated viruses. Journal of Virology. JVI0058721. PMID 34232726 DOI: 10.1128/JVI.00587-21  0.486
2021 Yu JC, Mietzsch M, Singh A, Jimenez Ybargollin A, Kailasan S, Chipman P, Bhattacharya N, Fakhiri J, Grimm D, Kapoor A, Kučinskaitė-Kodzė I, Žvirblienė A, Söderlund-Venermo M, McKenna R, Agbandje-McKenna M. Characterization of the GBoV1 Capsid and Its Antibody Interactions. Viruses. 13. PMID 33672786 DOI: 10.3390/v13020330  0.777
2021 Luo M, Mietzsch M, Chipman P, Song K, Xu C, Spear J, Sousa D, McKenna R, Söderlund-Venermo M, Agbandje-McKenna M. pH-Induced Conformational Changes of Human Bocavirus Capsids. Journal of Virology. PMID 33472934 DOI: 10.1128/JVI.02329-20  0.537
2021 Mietzsch M, Jose A, Chipman P, Bhattacharya N, Daneshparvar N, McKenna R, Agbandje-McKenna M. Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features. Viruses. 13. PMID 33450892 DOI: 10.3390/v13010101  0.541
2020 Kim JK, Lee C, Lim SW, Andring JT, Adhikari A, McKenna R, Kim CU. Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase. Iucrj. 7: 985-994. PMID 33209313 DOI: 10.1107/S2052252520011008  0.445
2020 Mietzsch M, Smith JK, Yu JC, Banala V, Emmanuel SN, Jose A, Chipman P, Bhattacharya N, McKenna R, Agbandje-McKenna M. Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies. Molecular Therapy. Methods & Clinical Development. 19: 362-373. PMID 33145372 DOI: 10.1016/j.omtm.2020.10.001  0.503
2020 Kim JK, Lee C, Lim SW, Adhikari A, Andring JT, McKenna R, Ghim CM, Kim CU. Elucidating the role of metal ions in carbonic anhydrase catalysis. Nature Communications. 11: 4557. PMID 32917908 DOI: 10.1038/S41467-020-18425-5  0.326
2020 Pénzes JJ, Pham HT, Chipman P, Bhattacharya N, McKenna R, Agbandje-McKenna M, Tijssen P. Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution. Proceedings of the National Academy of Sciences of the United States of America. PMID 32747554 DOI: 10.1073/Pnas.2008191117  0.587
2020 Koruza K, Murray AB, Mahon BP, Hopkins JB, Knecht W, McKenna R, Fisher SZ. Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX. International Journal of Molecular Sciences. 21. PMID 32722392 DOI: 10.3390/Ijms21155277  0.699
2020 Lins-Austin B, Patel S, Mietzsch M, Brooke D, Bennett A, Venkatakrishnan B, Van Vliet K, Smith AN, Long JR, McKenna R, Potter M, Byrne B, Boye SL, Bothner B, Heilbronn R, et al. Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking. Viruses. 12. PMID 32575696 DOI: 10.3390/V12060668  0.513
2020 Mietzsch M, McKenna R, Väisänen E, Yu JC, Ilyas M, Hull JA, Kurian J, Smith JK, Chipman P, Lasanajak Y, Smith D, Söderlund-Venermo M, Agbandje-McKenna M. Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology. Viruses. 12. PMID 32560452 DOI: 10.3390/V12060653  0.604
2020 Mietzsch M, Li Y, Kurian J, Kennon Smith J, Chipman P, McKenna R, Yang L, Agbandje-McKenna M. Structural characterization of a bat Adeno-associated virus capsid. Journal of Structural Biology. 107547. PMID 32522552 DOI: 10.1016/J.Jsb.2020.107547  0.584
2020 Bonardi A, Nocentini A, Bua S, Combs J, Lomelino C, Andring J, Lucarini L, Sgambellone S, Masini E, McKenna R, Gratteri P, Supuran CT. Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. Journal of Medicinal Chemistry. PMID 32519851 DOI: 10.1021/Acs.Jmedchem.0C00733  0.391
2020 Miranda CJ, Fernandez N, Kamel N, Turner D, Benzenhafer D, Bolch SN, Andring JT, McKenna R, Smith WC. An arrestin-1 surface opposite of its interface with photo-activated rhodopsin engages with enolase-1. The Journal of Biological Chemistry. PMID 32238431 DOI: 10.1074/Jbc.Ra120.013043  0.33
2020 Andring JT, Kim CU, McKenna R. Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Iucrj. 7: 287-293. PMID 32148856 DOI: 10.1107/S2052252520000986  0.372
2020 Combs JE, Andring JT, McKenna R. Neutron crystallographic studies of carbonic anhydrase. Methods in Enzymology. 634: 281-309. PMID 32093837 DOI: 10.1016/Bs.Mie.2020.01.003  0.386
2020 Petreni A, Bonardi A, Lomelino C, Osman SM, ALOthman ZA, Eldehna WM, El-Haggar R, McKenna R, Nocentini A, Supuran CT. Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells. European Journal of Medicinal Chemistry. 190: 112112. PMID 32044580 DOI: 10.1016/J.Ejmech.2020.112112  0.362
2020 Tondnevis F, Dudenhausen EE, Miller AM, McKenna R, Altschul SF, Bloom LB, Neuwald AF. Deep Analysis of Residue Constraints (DARC): identifying determinants of protein functional specificity. Scientific Reports. 10: 1691. PMID 32015389 DOI: 10.1038/S41598-019-55118-6  0.316
2019 Mietzsch M, Barnes C, Hull JA, Chipman P, Xie J, Bhattacharya N, Sousa D, McKenna R, Gao G, Agbandje-McKenna M. Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8. Journal of Virology. PMID 31826994 DOI: 10.1128/Jvi.01769-19  0.577
2019 Bua S, Lomelino CL, Murray AB, Osman SM, Alothman ZA, Bozdag M, Aziz HAA, Eldehna WM, McKenna R, Nocentini A, Supuran CT. "A Sweet Combination": Developing saccharin and acesulfame K structures for selectively targeting the tumor-associated carbonic anhydrases IX and XII. Journal of Medicinal Chemistry. PMID 31794211 DOI: 10.2210/Pdb6U4T/Pdb  0.37
2019 Rivière G, Peng EQ, Brotgandel A, Andring JT, Lakshmanan RV, Agbandje-McKenna M, McKenna R, Brady LJ, Long JR. Characterization of an intermolecular quaternary interaction between discrete segments of the Streptococcus mutans adhesin P1 by NMR Spectroscopy. The Febs Journal. PMID 31782893 DOI: 10.1111/Febs.15158  0.537
2019 Mboge MY, Chen Z, Khokhar D, Wolff A, Ai L, Heldermon CD, Bozdag M, Carta F, Supuran CT, Brown KD, McKenna R, Frost CJ, Frost SC. A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells. The Biochemical Journal. PMID 31072911 DOI: 10.1042/Bcj20190177  0.321
2019 Kurian JJ, Lakshmanan R, Chmely WM, Hull JA, Yu JC, Bennett A, McKenna R, Agbandje-McKenna M. Adeno-Associated Virus VP1u Exhibits Protease Activity. Viruses. 11. PMID 31035643 DOI: 10.3390/V11050399  0.57
2019 Murray AB, Quadri M, Li H, McKenna R, Horenstein NA. Synthesis of saccharin-glycoconjugates targeting carbonic anhydrase using a one-pot cyclization/deprotection strategy. Carbohydrate Research. 476: 65-70. PMID 30921738 DOI: 10.1016/J.Carres.2019.03.001  0.32
2019 Lomelino CL, McKenna R. Carbonic anhydrase II in complex with carboxylic acid-based inhibitors. Acta Crystallographica. Section F, Structural Biology Communications. 75: 166-170. PMID 30839290 DOI: 10.1107/S2053230X18018344  0.406
2019 Koruza K, Mahon BP, Blakeley MP, Ostermann A, Schrader TE, McKenna R, Knecht W, Zoë Fisher S. Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative. Journal of Structural Biology. PMID 30639924 DOI: 10.2210/Pdb6Gcy/Pdb  0.38
2019 Andring JT, Dohle W, Tu C, Potter BVL, McKenna R. 3,17 beta-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity. Journal of Medicinal Chemistry. 62: 2202-2212. DOI: 10.2210/Pdb6E8P/Pdb  0.374
2018 Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, Bozdag M, Carta F, Supuran CT, McKenna R, Frost SC. Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition. Plos One. 13: e0207417. PMID 30452451 DOI: 10.1371/Journal.Pone.0207417  0.341
2018 Forero-Quintero LS, Ames S, Schneider HP, Thyssen A, Boone CD, Andring JT, McKenna R, Casey JR, Deitmer JW, Becker HM. Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70. The Journal of Biological Chemistry. PMID 30446621 DOI: 10.1074/Jbc.Ra118.005536  0.331
2018 Nocentini A, Trallori E, Singh S, Lomelino CL, Bartolucci G, Di Cesare Mannelli L, Ghelardini C, McKenna R, Gratteri P, Supuran CT. 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles. Journal of Medicinal Chemistry. PMID 30433782 DOI: 10.1021/Acs.Jmedchem.8B01504  0.352
2018 Jose A, Mietzsch M, Smith K, Kurian J, Chipman P, McKenna R, Chiorini J, Agbandje-McKenna M. High resolution structural characterization of a new AAV5 antibody epitope toward engineering antibody resistant recombinant gene delivery vectors. Journal of Virology. PMID 30333169 DOI: 10.1128/Jvi.01394-18  0.546
2018 Bennett A, Rodriguez D, Lister S, Boulton M, McKenna R, Agbandje-McKenna M. Assembly and disassembly intermediates of maize streak geminivirus. Virology. 525: 224-236. PMID 30300759 DOI: 10.1016/J.Virol.2018.09.011  0.507
2018 Mahon BP, McKenna R. Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography. Methods in Molecular Biology (Clifton, N.J.). 1826: 9-39. PMID 30194591 DOI: 10.1007/978-1-4939-8645-3_2  0.346
2018 Tan YZ, Aiyer S, Mietzsch M, Hull JA, McKenna R, Grieger J, Samulski RJ, Baker TS, Agbandje-McKenna M, Lyumkis D. Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant. Nature Communications. 9: 3628. PMID 30194371 DOI: 10.1038/S41467-018-06076-6  0.56
2018 Murray A, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R. Structural Mapping of Anion inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa. Chemmedchem. PMID 30088334 DOI: 10.1002/cmdc.201800375  0.692
2018 Lomelino CL, Murray AB, Supuran CT, McKenna R. Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. Acs Medicinal Chemistry Letters. 9: 657-661. PMID 30034596 DOI: 10.1021/Acsmedchemlett.8B00100  0.408
2018 Lomelino CL, Kim JK, Lee C, Lim SW, Andring JT, Mahon BP, Chung M, Kim CU, McKenna R. Carbonic anhydrase II microcrystals suitable for XFEL studies. Acta Crystallographica. Section F, Structural Biology Communications. 74: 327-330. PMID 29870015 DOI: 10.1107/S2053230X18006118  0.381
2018 Nocentini A, Ceruso M, Bua S, Lomelino CL, Andring J, McKenna R, Lanzi C, Sgambellone S, Pecori R, Matucci R, Filippi L, Gratteri P, Carta F, Masini E, Selleri S, et al. Discovery of β-adrenergic receptors blocker - carbonic anhydrase inhibitor hybrids for multitargeted anti-glaucoma therapy. Journal of Medicinal Chemistry. PMID 29851481 DOI: 10.1021/Acs.Jmedchem.8B00625  0.3
2018 Burg M, Rosebrough C, Drouin LM, Bennett A, Mietzsch M, Chipman P, McKenna R, Sousa D, Potter M, Byrne B, Jude Samulski R, Agbandje-McKenna M. Atomic structure of a rationally engineered gene delivery vector, AAV2.5. Journal of Structural Biology. PMID 29775653 DOI: 10.1016/J.Jsb.2018.05.004  0.58
2018 Singh S, Lomelino CL, Mboge MY, Frost SC, McKenna R. Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site. Molecules (Basel, Switzerland). 23. PMID 29710858 DOI: 10.3390/Molecules23051045  0.334
2018 Bennett AD, Wong K, Lewis J, Tseng YS, Smith JK, Chipman P, McKenna R, Samulski RJ, Kleinschmidt J, Agbandje-McKenna M. AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition. Virology. 518: 369-376. PMID 29604478 DOI: 10.1016/J.Virol.2018.03.007  0.53
2018 Mboge MY, Mahon BP, McKenna R, Frost SC. Carbonic Anhydrases: Role in pH Control and Cancer. Metabolites. 8. PMID 29495652 DOI: 10.3390/Metabo8010019  0.302
2018 Kovalevsky A, Aggarwal M, Velazquez H, Cuneo MJ, Blakeley MP, Weiss KL, Smith JC, Fisher SZ, McKenna R. "To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation. Structure (London, England : 1993). PMID 29429876 DOI: 10.1016/J.Str.2018.01.006  0.811
2018 Bhatt A, Mondal UK, Supuran CT, Ilies MA, McKenna R. Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function. Molecular Neurobiology. PMID 29423818 DOI: 10.1007/S12035-017-0854-2  0.366
2018 Andring JT, Lomelino CL, Tu C, Silverman DN, McKenna R, Swenson ER. Carbonic Anhydrase II Does Not Exhibit Nitrate Reductase or Nitrous Anhydrase Activity. Free Radical Biology & Medicine. PMID 29355738 DOI: 10.1016/J.Freeradbiomed.2018.01.015  0.396
2018 Kim JK, Lomelino CL, Avvaru BS, Mahon BP, McKenna R, Park S, Kim CU. Active-site solvent replenishment observed during human carbonic anhydrase II catalysis. Iucrj. 5: 93-102. PMID 29354275 DOI: 10.2210/Pdb5Y2S/Pdb  0.794
2018 Ilyas M, Mietzsch M, Kailasan S, Väisänen E, Luo M, Chipman P, Smith JK, Kurian J, Sousa D, McKenna R, Söderlund-Venermo M, Agbandje-McKenna M. Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy. Viruses. 10. PMID 29300333 DOI: 10.3390/V10010022  0.79
2018 Murray AB, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R. Structural Mapping of Anion Inhibitors to beta-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa. Chemmedchem. 13: 2024-2029. DOI: 10.2210/Pdb6D2N/Pdb  0.719
2018 Mietzsch M, Luo M, Yu JC, Kailasan S, Ilyas M, Chipman P, Sousa D, Soderlund-Venermo M, McKenna R, Agbandje-McKenna M. Structural Characterization of Emerging Pathogenic Human Parvoviruses Microscopy and Microanalysis. 24: 1214-1215. DOI: 10.1017/S1431927618006554  0.776
2018 Murray AB, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R. Cover Feature: Structural Mapping of Anion Inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa (ChemMedChem 19/2018) Chemmedchem. 13: 2013-2013. DOI: 10.1002/Cmdc.201800628  0.675
2017 Murray AB, Lomelino CL, Supuran CT, McKenna R. "Seriously Sweet": Acesulfame K exhibits selective inhibition using alternative binding modes in carbonic anhydrase isoforms. Journal of Medicinal Chemistry. PMID 29266943 DOI: 10.1021/Acs.Jmedchem.7B01470  0.352
2017 Nocentini A, Bua S, Lomelino CL, McKenna R, Menicatti M, Bartolucci G, Tenci B, Di Cesare Mannelli L, Ghelardini C, Gratteri P, Supuran CT. Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. Acs Medicinal Chemistry Letters. 8: 1314-1319. PMID 29259754 DOI: 10.1021/Acsmedchemlett.7B00399  0.371
2017 Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas A. Crystal Structure of Cleaved Serp-1, a Myxomavirus-derived Immune Modulating Serpin; Structural Design of Serpin Reactive Center Loop (RCL) Peptides with Improved Therapeutic Function. Biochemistry. PMID 29227673 DOI: 10.1021/Acs.Biochem.7B01171  0.313
2017 Lomelino CL, Andring JT, McKenna R, Kilberg MS. Asparagine synthetase: Function, structure, and role in disease. The Journal of Biological Chemistry. PMID 29084849 DOI: 10.1074/Jbc.R117.819060  0.314
2017 Pittman N, Misseldine A, Geilen L, Halder S, Smith JK, Kurian J, Chipman P, Janssen M, Mckenna R, Baker TS, D'Abramo A, Cotmore S, Tattersall P, Agbandje-McKenna M. Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. Viruses. 9. PMID 29084163 DOI: 10.3390/V9110321  0.572
2017 Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. Acs Medicinal Chemistry Letters. 8: 941-946. PMID 28947941 DOI: 10.1021/Acsmedchemlett.7B00229  0.393
2017 Bennett A, Patel S, Mietzsch M, Jose A, Lins-Austin B, Yu JC, Bothner B, McKenna R, Agbandje-McKenna M. Thermal Stability as a Determinant of AAV Serotype Identity. Molecular Therapy. Methods & Clinical Development. 6: 171-182. PMID 28828392 DOI: 10.1016/J.Omtm.2017.07.003  0.519
2017 Mboge MY, Mahon BP, Lamas N, Socorro L, Carta F, Supuran CT, Frost SC, McKenna R. Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides. European Journal of Medicinal Chemistry. 132: 184-191. PMID 28363153 DOI: 10.1016/J.Ejmech.2017.03.026  0.314
2017 Mietzsch M, Kailasan S, Garrison J, Ilyas M, Chipman P, Kantola K, Janssen ME, Spear J, Sousa D, McKenna R, Brown K, Söderlund-Venermo M, Baker T, Agbandje-McKenna M. Structural insights into emerging pediatric pathogens human bocaparvoviruses. Journal of Virology. PMID 28331084 DOI: 10.1128/Jvi.00261-17  0.784
2017 Bhatt A, Ilies M, McKenna R. Crystallographic insight into enhanced catalytic activity of carbonic anhydrase II using 'activating' ligands Acta Crystallographica Section a Foundations and Advances. 73: a8-a8. DOI: 10.1107/S0108767317099913  0.352
2017 Kurian JJ, Bennett A, Hull J, Janssen M, Baker T, McKenna R, Agbandje-McKenna M. Characterization of pH-dependent structural changes in adeno-associated virus by cryo-electron microscopy and three-dimensional image reconstruction Acta Crystallographica Section a Foundations and Advances. 73: a59-a59. DOI: 10.1107/S010876731709941X  0.522
2017 Mietzsch M, Vliet Kv, Lins-Austin B, Yu C, Janssen ME, Bröcker F, Kaplonek P, Cardone G, McKenna R, Crystal R, Wilson J, Baker T, Seeberger PH, Heilbronn R, Agbandje-McKenna M. Analysis of the AAVrh. 10 Capsid Structure and Its Antigenic and Receptor Interactions Molecular Therapy. 25: 335-335. DOI: 10.1016/J.Ymthe.2017.04.025  0.52
2016 Aggarwal M, Kovalevsky AY, Velazquez H, Fisher SZ, Smith JC, McKenna R. Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug. Iucrj. 3: 319-325. PMID 28461893 DOI: 10.1107/S2052252516010514  0.831
2016 Callaway HM, Feng KH, Lee DW, Allison AB, Pinard M, McKenna R, Agbandje-McKenna M, Hafenstein S, Parrish CR. Parvovirus capsid structures required for infection: mutations controlling receptor recognition and protease cleavages. Journal of Virology. PMID 27847360 DOI: 10.1128/Jvi.01871-16  0.554
2016 Liu Z, Huang X, Hu L, Pham L, Poole KM, Tang Y, Mahon BP, Tang W, Li K, Goldfarb NE, Dunn BM, McKenna R, Fanucci GE. Effects of Hinge Region Natural Polymorphisms on Human Immunodeficiency Virus-1 Protease Structure, Dynamics and Drug-Pressure Evolution. The Journal of Biological Chemistry. PMID 27576689 DOI: 10.1074/Jbc.M116.747568  0.355
2016 Drouin LM, Lins B, Janssen M, Bennett A, Chipman P, McKenna R, Chen W, Muzyczka N, Cardone G, Baker TS, Agbandje-McKenna M. Cryo-electron microscopy reconstruction and stability studies of Wild-Type and R432A Variant of AAV2 Reveals Capsid Structural Stability is a Major Factor in Genome Packaging. Journal of Virology. PMID 27440903 DOI: 10.1128/Jvi.00575-16  0.565
2016 Mahon BP, Bhatt A, Socorro L, Driscoll JM, Okoh C, Lomelino CL, Mboge MY, Kurian JJ, Tu C, Agbandje-McKenna M, Frost SC, McKenna R. Structure of carbonic anhydrase IX is adapted for low pH catalysis. Biochemistry. PMID 27439028 DOI: 10.1021/Acs.Biochem.6B00243  0.579
2016 Lomelino CL, Supuran CT, McKenna R. Non-Classical Inhibition of Carbonic Anhydrase. International Journal of Molecular Sciences. 17. PMID 27438828 DOI: 10.3390/Ijms17071150  0.322
2016 Tseng YS, Vliet KV, Rao L, McKenna R, Byrne BJ, Asokan A, Agbandje-McKenna M. Generation and characterization of anti-AAV8 and anti-AAV9 monoclonal antibodies. Journal of Virological Methods. PMID 27424005 DOI: 10.1016/J.Jviromet.2016.07.009  0.512
2016 Lomelino C, McKenna R. Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011-2016). Expert Opinion On Therapeutic Patents. 1-10. PMID 27387065 DOI: 10.1080/13543776.2016.1203904  0.329
2016 Pinard MA, Kurian JJ, Aggarwal M, Agbandje-McKenna M, McKenna R. Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3. Acta Crystallographica. Section F, Structural Biology Communications. 72: 573-7. PMID 27380376 DOI: 10.1107/S2053230X16009286  0.756
2016 Kim CU, Song H, Avvaru BS, Gruner SM, Park S, McKenna R. Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114542 DOI: 10.1073/Pnas.1520786113  0.8
2016 Tondnevis F, Weiss TM, Matsui T, Bloom LB, Mckenna R. Solution Structure of an "open" E. coli Pol III Clamp Loader Sliding Clamp Complex. Journal of Structural Biology. PMID 26968362 DOI: 10.1016/J.Jsb.2016.03.003  0.351
2016 Huang LY, Patel A, Ng R, Miller EB, Halder S, McKenna R, Asokan A, Agbandje-McKenna M. Characterization of the Adeno-associated virus 1 and 6 sialic acid binding site. Journal of Virology. PMID 26962225 DOI: 10.1128/Jvi.00161-16  0.58
2016 Kailasan S, Garrison J, Ilyas M, Chipman P, McKenna R, Kantola K, Söderlund-Venermo M, Kučinskaitė-Kodzė I, Žvirblienė A, Agbandje-McKenna M. Mapping Antigenic Epitopes on the Human Bocavirus Capsid. Journal of Virology. 90: 4670-80. PMID 26912619 DOI: 10.1128/Jvi.02998-15  0.768
2016 Lomelino CL, Mahon BP, McKenna R, Carta F, Supuran CT. Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111. Bioorganic & Medicinal Chemistry. 24: 976-81. PMID 26810836 DOI: 10.1016/J.Bmc.2016.01.019  0.431
2016 Vullo D, Bhatt A, Mahon BP, McKenna R, Supuran CT. Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorganic & Medicinal Chemistry Letters. 26: 401-405. PMID 26691758 DOI: 10.1016/J.Bmcl.2015.11.104  0.359
2016 Mboge MY, Chen Z, Mahon BP, Lamas N, Tu S, Carta F, Superan CT, McKenna R, Frost SC. Abstract B25: Characterization, targeting, and modulation of carbonic anhydrase IX activity for the development of small-molecule inhibitors to treat triple-negative breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-B25  0.34
2016 Fisher Z, Koruza K, Mahon B, Okoh C, Knecht W, McKenna R. Neutron crystallographic studies of cancer-related human carbonic anhydrase IX reveal details of hydrogen-bonding in inhibitor binding. Acta Crystallographica Section A. 72. DOI: 10.1107/S2053273316096832  0.348
2016 Mahon BP, Kurian JJ, Lomelino CL, Smith IR, Socorro L, Bennett A, Hendon AM, Chipman P, Savin DA, Agbandje-McKenna M, McKenna R. Microbatch Mixing: “Shaken not Stirred”, a Method for Macromolecular Microcrystal Production for Serial Crystallography Crystal Growth & Design. 16: 6214-6221. DOI: 10.1021/Acs.Cgd.6B00643  0.568
2016 Drouin LM, Lins B, Janssen M, Bennett A, Chipman PR, McKenna R, Chen W, Muzyczka N, Cardone G, Baker TS, Agbandje-McKenna M. Structural Rearrangements in R432A Variant of AAV2 Affect Genome Packaging Microscopy and Microanalysis. 22: 1134-1135. DOI: 10.1017/S1431927616006516  0.497
2016 Huang L, Patel A, Ng R, Miller EB, Halder S, McKenna R, Asokan A, Agbandje-McKenna M. 727. Characterizing the Adeno-Associated Virus 1 Sialic Receptor Binding Site and Its Overlap with Antigenic Epitopes Molecular Therapy. 24: S287. DOI: 10.1016/S1525-0016(16)33535-3  0.577
2016 Liu Z, Huang X, Hu L, Pham L, Poole K, Tang Y, Mahon BP, Tang W, Li K, Goldfarb NE, Dunn BM, McKenna R, Fanucci GE. Implication of Natural Polymorphism in Hinge Region of HIV-1 Protease on Protein Conformations, Local Structures and Backbone Dynamics Biophysical Journal. 110: 207a. DOI: 10.1016/J.Bpj.2015.11.1154  0.326
2016 Lomelino CL, Mahon BP, McKenna R, Carta F, Supuran CT. Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111 Bioorganic and Medicinal Chemistry. 24: 976-981. DOI: 10.1016/j.bmc.2016.01.019  0.316
2015 Aggarwal M, McKenna R. Carbonic Anhydrases: Nature's Way to Balance CO2 Concentration. Biochemistry & Molecular Biology Journal. 1. PMID 28317035 DOI: 10.21767/2471-8084.100008  0.626
2015 Tondnevis F, Gillilan RE, Bloom LB, McKenna R. Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ψχ heterodimer. Structural Dynamics (Melville, N.Y.). 2: 054701. PMID 26798827 DOI: 10.1063/1.4927407  0.334
2015 Aggarwal M, Chua TK, Pinard MA, Szebenyi DM, McKenna R. Carbon Dioxide "Trapped" in a β-Carbonic Anhydrase. Biochemistry. 54: 6631-8. PMID 26457866 DOI: 10.1021/Acs.Biochem.5B00987  0.724
2015 Pinard MA, Aggarwal M, Mahon BP, Tu C, McKenna R. A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1352-8. PMID 26457530 DOI: 10.1107/S2053230X1501239X  0.719
2015 Halder S, Van Vliet K, Smith JK, Duong TT, McKenna R, Wilson JM, Agbandje-McKenna M. Structure of neurotropic adeno-associated virus AAVrh.8. Journal of Structural Biology. PMID 26334681 DOI: 10.1016/J.Jsb.2015.08.017  0.584
2015 Díaz-Torres NA, Mahon BP, Boone CD, Pinard MA, Tu C, Ng R, Agbandje-McKenna M, Silverman D, Scott K, McKenna R. Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration. Acta Crystallographica. Section D, Biological Crystallography. 71: 1745-56. PMID 26249355 DOI: 10.1107/S1399004715012183  0.586
2015 Mahon BP, Lomelino CL, Ladwig J, Rankin GM, Driscoll JM, Salguero AL, Pinard MA, Vullo D, Supuran CT, Poulsen SA, McKenna R. Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates. Journal of Medicinal Chemistry. 58: 6630-8. PMID 26203869 DOI: 10.1021/Acs.Jmedchem.5B00845  0.413
2015 Pinard MA, Lotlikar SR, Boone CD, Vullo D, Supuran CT, Patrauchan MA, McKenna R. Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry. PMID 26068018 DOI: 10.1016/J.Bmc.2015.05.029  0.419
2015 Mahon BP, Díaz-Torres NA, Pinard MA, Tu C, Silverman DN, Scott KM, McKenna R. Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium. Bioorganic & Medicinal Chemistry Letters. PMID 25998503 DOI: 10.1016/J.Bmcl.2015.05.001  0.361
2015 Michalczyk R, Unkefer CJ, Bacik JP, Schrader TE, Ostermann A, Kovalevsky AY, McKenna R, Fisher SZ. Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer. Proceedings of the National Academy of Sciences of the United States of America. 112: 5673-8. PMID 25902526 DOI: 10.1073/Pnas.1502255112  0.729
2015 Pinard MA, Mahon B, McKenna R. Probing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitors. Biomed Research International. 2015: 453543. PMID 25811028 DOI: 10.1155/2015/453543  0.386
2015 Carta F, Di Cesare Mannelli L, Pinard M, Ghelardini C, Scozzafava A, McKenna R, Supuran CT. A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects. Bioorganic & Medicinal Chemistry. 23: 1828-40. PMID 25766630 DOI: 10.1016/J.Bmc.2015.02.027  0.334
2015 Boone CD, Rasi V, Tu C, McKenna R. Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II. The Febs Journal. 282: 1445-57. PMID 25683338 DOI: 10.1111/Febs.13232  0.414
2015 Mahon BP, Hendon AM, Driscoll JM, Rankin GM, Poulsen SA, Supuran CT, McKenna R. Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors. Bioorganic & Medicinal Chemistry. 23: 849-54. PMID 25614109 DOI: 10.1016/J.Bmc.2014.12.030  0.394
2015 Noor SI, Dietz S, Heidtmann H, Boone CD, McKenna R, Deitmer JW, Becker HM. Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II. The Journal of Biological Chemistry. 290: 4476-86. PMID 25561737 DOI: 10.1074/Jbc.M114.624577  0.341
2015 Kailasan S, Halder S, Gurda B, Bladek H, Chipman PR, McKenna R, Brown K, Agbandje-McKenna M. Structure of an enteric pathogen, bovine parvovirus. Journal of Virology. 89: 2603-14. PMID 25520501 DOI: 10.1128/Jvi.03157-14  0.802
2015 Goldfarb NE, Ohanessian M, Biswas S, McGee TD, Mahon BP, Ostrov DA, Garcia J, Tang Y, McKenna R, Roitberg A, Dunn BM. Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency. Biochemistry. 54: 422-33. PMID 25513833 DOI: 10.1021/Bi501088E  0.365
2015 Tseng YS, Gurda BL, Chipman P, McKenna R, Afione S, Chiorini JA, Muzyczka N, Olson NH, Baker TS, Kleinschmidt J, Agbandje-McKenna M. Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity. Journal of Virology. 89: 1794-808. PMID 25410874 DOI: 10.1128/Jvi.02710-14  0.572
2015 Mahon BP, Bhatt A, Vullo D, Supuran CT, McKenna R. Exploration of anionic inhibition of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 gammaproteobacterium: A potential bio-catalytic agent for industrial CO2 removal Chemical Engineering Science. 138: 575-580. DOI: 10.1016/J.Ces.2015.07.030  0.364
2014 Wolmarans E, Sippel K, McKenna R, Joubert A. Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line. Cell & Bioscience. 4: 68. PMID 25937890 DOI: 10.1186/2045-3701-4-68  0.742
2014 Bozdag M, Pinard M, Carta F, Masini E, Scozzafava A, McKenna R, Supuran CT. A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects. Journal of Medicinal Chemistry. 57: 9673-86. PMID 25358036 DOI: 10.1021/Jm501497M  0.421
2014 Heim KP, Crowley PJ, Long JR, Kailasan S, McKenna R, Brady LJ. An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1. Proceedings of the National Academy of Sciences of the United States of America. 111: 15746-51. PMID 25331888 DOI: 10.1073/Pnas.1413018111  0.756
2014 West D, Pinard MA, Tu C, Silverman DN, McKenna R. Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest. Acta Crystallographica. Section F, Structural Biology Communications. 70: 1324-7. PMID 25286933 DOI: 10.1107/S2053230X14018135  0.442
2014 Moeker J, Mahon BP, Bornaghi LF, Vullo D, Supuran CT, McKenna R, Poulsen SA. Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates. Journal of Medicinal Chemistry. 57: 8635-45. PMID 25254302 DOI: 10.1021/Jm5012935  0.36
2014 Pala N, Micheletto L, Sechi M, Aggarwal M, Carta F, McKenna R, Supuran CT. Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry. Acs Medicinal Chemistry Letters. 5: 927-30. PMID 25147616 DOI: 10.1021/Ml500196T  0.72
2014 Aggarwal M, Kondeti B, Tu C, Maupin CM, Silverman DN, McKenna R. Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. Iucrj. 1: 129-35. PMID 25075329 DOI: 10.1107/S2052252514004096  0.744
2014 Mohandas R, Sautina L, Beem E, Schuler A, Chan WY, Domsic J, McKenna R, Johnson RJ, Segal MS. Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret. Experimental Cell Research. 326: 136-42. PMID 24925478 DOI: 10.1016/J.Yexcr.2014.05.025  0.727
2014 Boone CD, Tu C, McKenna R. Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II. Acta Crystallographica. Section D, Biological Crystallography. 70: 1758-63. PMID 24914985 DOI: 10.1107/S1399004714007457  0.463
2014 Mikals K, Nam HJ, Van Vliet K, Vandenberghe LH, Mays LE, McKenna R, Wilson JM, Agbandje-McKenna M. The structure of AAVrh32.33, a novel gene delivery vector. Journal of Structural Biology. 186: 308-17. PMID 24704217 DOI: 10.1016/J.Jsb.2014.03.020  0.557
2014 Boone CD, Zhong G, Smeltz M, James MO, McKenna R. Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a). Acta Crystallographica. Section F, Structural Biology Communications. 70: 187-9. PMID 24637752 DOI: 10.1107/S2053230X13033591  0.33
2014 Wolmarans E, Mqoco TV, Stander A, Nkandeu SD, Sippel K, McKenna R, Joubert A. Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells. Cellular & Molecular Biology Letters. 19: 98-115. PMID 24563014 DOI: 10.2478/S11658-014-0183-7  0.733
2014 Halder S, Cotmore S, Heimburg-Molinaro J, Smith DF, Cummings RD, Chen X, Trollope AJ, North SJ, Haslam SM, Dell A, Tattersall P, McKenna R, Agbandje-McKenna M. Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition. Plos One. 9: e86909. PMID 24475195 DOI: 10.1371/Journal.Pone.0086909  0.544
2014 Salganik M, Aydemir F, Nam HJ, McKenna R, Agbandje-McKenna M, Muzyczka N. Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes. Journal of Virology. 88: 1071-9. PMID 24198419 DOI: 10.1128/Jvi.02093-13  0.523
2014 McKenna R, Supuran CT. Carbonic anhydrase inhibitors drug design. Sub-Cellular Biochemistry. 75: 291-323. PMID 24146385 DOI: 10.1007/978-94-007-7359-2_15  0.374
2014 Boone CD, Pinard M, McKenna R, Silverman D. Catalytic mechanism of α-class carbonic anhydrases: CO2 hydration and proton transfer. Sub-Cellular Biochemistry. 75: 31-52. PMID 24146373 DOI: 10.1007/978-94-007-7359-2_3  0.37
2014 Aggarwal M, Tu C, Silverman D, McKenna R. Insights into Activity Enhancement of H64A Carbonic Anhydrase by Imidazoles Acta Crystallographica Section a Foundations and Advances. 70: C803-C803. DOI: 10.1107/S2053273314091967  0.726
2013 Pinard MA, Boone CD, Rife BD, Supuran CT, McKenna R. Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorganic & Medicinal Chemistry. 21: 7210-5. PMID 24090602 DOI: 10.1016/J.Bmc.2013.08.033  0.363
2013 Rayaprolu V, Kruse S, Kant R, Venkatakrishnan B, Movahed N, Brooke D, Lins B, Bennett A, Potter T, McKenna R, Agbandje-McKenna M, Bothner B. Comparative analysis of adeno-associated virus capsid stability and dynamics. Journal of Virology. 87: 13150-60. PMID 24067976 DOI: 10.1128/Jvi.01415-13  0.542
2013 Boone CD, Gill S, Tu C, Silverman DN, McKenna R. Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II. Archives of Biochemistry and Biophysics. 539: 31-7. PMID 24036123 DOI: 10.1016/J.Abb.2013.09.001  0.344
2013 Güzel-Akdemir O, Biswas S, Lastra K, McKenna R, Supuran CT. Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry. 21: 6674-80. PMID 24012377 DOI: 10.1016/J.Bmc.2013.08.011  0.46
2013 Biswas S, McKenna R, Supuran CT. Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry Letters. 23: 5646-9. PMID 23993330 DOI: 10.1016/J.Bmcl.2013.08.019  0.438
2013 Govindasamy L, DiMattia MA, Gurda BL, Halder S, McKenna R, Chiorini JA, Muzyczka N, Zolotukhin S, Agbandje-McKenna M. Structural insights into adeno-associated virus serotype 5. Journal of Virology. 87: 11187-99. PMID 23926356 DOI: 10.1128/Jvi.00867-13  0.588
2013 Pinard M, Lotlikar S, Patrauchan MA, McKenna R. Preliminary X-ray crystallographic analysis of β-carbonic anhydrase psCA3 from Pseudomonas aeruginosa. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 891-4. PMID 23908036 DOI: 10.1107/S1744309113017594  0.373
2013 Boone CD, Habibzadegan A, Tu C, Silverman DN, McKenna R. Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond. Acta Crystallographica. Section D, Biological Crystallography. 69: 1414-22. PMID 23897465 DOI: 10.1107/S0907444913008743  0.421
2013 Gurda BL, DiMattia MA, Miller EB, Bennett A, McKenna R, Weichert WS, Nelson CD, Chen WJ, Muzyczka N, Olson NH, Sinkovits RS, Chiorini JA, Zolotutkhin S, Kozyreva OG, Samulski RJ, et al. Capsid antibodies to different adeno-associated virus serotypes bind common regions. Journal of Virology. 87: 9111-24. PMID 23760240 DOI: 10.1128/Jvi.00622-13  0.539
2013 Aggarwal M, Boone CD, Kondeti B, Tu C, Silverman DN, McKenna R. Effects of cryoprotectants on the structure and thermostability of the human carbonic anhydrase II-acetazolamide complex. Acta Crystallographica. Section D, Biological Crystallography. 69: 860-5. PMID 23633596 DOI: 10.1107/S0907444913002771  0.748
2013 Aggarwal M, Kondeti B, McKenna R. Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review. Expert Opinion On Therapeutic Patents. 23: 717-24. PMID 23514045 DOI: 10.1517/13543776.2013.782394  0.646
2013 Biswas S, Carta F, Scozzafava A, McKenna R, Supuran CT. Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry. 21: 2314-8. PMID 23490152 DOI: 10.1016/J.Bmc.2013.02.022  0.436
2013 Halder S, Nam HJ, Govindasamy L, Vogel M, Dinsart C, Salomé N, McKenna R, Agbandje-McKenna M. Structural characterization of H-1 parvovirus: comparison of infectious virions to empty capsids. Journal of Virology. 87: 5128-40. PMID 23449783 DOI: 10.1128/Jvi.03416-12  0.589
2013 Venkatakrishnan B, Yarbrough J, Domsic J, Bennett A, Bothner B, Kozyreva OG, Samulski RJ, Muzyczka N, McKenna R, Agbandje-McKenna M. Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking. Journal of Virology. 87: 4974-84. PMID 23427155 DOI: 10.1128/Jvi.02524-12  0.786
2013 Stander BA, Joubert F, Tu C, Sippel KH, McKenna R, Joubert AM. Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells. Plos One. 8: e53853. PMID 23382857 DOI: 10.1371/Journal.Pone.0053853  0.751
2013 Mikulski R, West D, Sippel KH, Avvaru BS, Aggarwal M, Tu C, McKenna R, Silverman DN. Water networks in fast proton transfer during catalysis by human carbonic anhydrase II. Biochemistry. 52: 125-31. PMID 23215152 DOI: 10.1021/Bi301099K  0.817
2013 Aggarwal M, Boone CD, Kondeti B, McKenna R. Structural annotation of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry. 28: 267-77. PMID 23137351 DOI: 10.3109/14756366.2012.737323  0.722
2013 Zimmerman S, Domsic JF, Tu C, Robbins AH, McKenna R, Silverman DN, Ferry JG. Role of Trp19 and Tyr200 in catalysis by the γ-class carbonic anhydrase from Methanosarcina thermophila. Archives of Biochemistry and Biophysics. 529: 11-7. PMID 23111186 DOI: 10.1016/J.Abb.2012.10.010  0.77
2013 Aggarwal M, Kondeti B, McKenna R. Insights towards sulfonamide drug specificity in α-carbonic anhydrases. Bioorganic & Medicinal Chemistry. 21: 1526-33. PMID 22985956 DOI: 10.1016/J.Bmc.2012.08.019  0.689
2013 Stander BA, Joubert F, Tu C, Sippel KH, McKenna R, Joubert AM. Correction: Signaling Pathways of ESE-16, an Antimitotic and Anticarbonic Anhydrase Estradiol Analog, in Breast Cancer Cells Plos One. 8. DOI: 10.1371/annotation/6afd5e63-46d6-42a1-b661-6688a04bfd16  0.705
2013 Boone CD, Gill S, Habibzadegan A, McKenna R. Carbonic anhydrase: An efficient enzyme with possible global implications International Journal of Chemical Engineering. DOI: 10.1155/2013/813931  0.322
2013 Aggarwal M, Kovalevsky A, McKenna R, Silverman D, Fisher Z. Neutron protein crystallography reveals unique details of clinical drug binding to a human target enzyme Neutron News. 24: 20-23. DOI: 10.1080/10448632.2013.831317  0.675
2012 Stander BA, Joubert F, Tu C, Sippel KH, McKenna R, Joubert AM. In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity. Plos One. 7: e52205. PMID 23300615 DOI: 10.1371/Journal.Pone.0052205  0.765
2012 Halder S, Nam HJ, Govindasamy L, Vogel M, Dinsart C, Salomé N, McKenna R, Agbandje-McKenna M. Production, purification, crystallization and structure determination of H-1 Parvovirus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 1571-6. PMID 23192051 DOI: 10.1107/S1744309112045563  0.564
2012 West D, Kim CU, Tu C, Robbins AH, Gruner SM, Silverman DN, McKenna R. Structural and kinetic effects on changes in the CO(2) binding pocket of human carbonic anhydrase II. Biochemistry. 51: 9156-63. PMID 23098192 DOI: 10.1021/Bi301155Z  0.453
2012 Marini AM, Maresca A, Aggarwal M, Orlandini E, Nencetti S, Da Settimo F, Salerno S, Simorini F, La Motta C, Taliani S, Nuti E, Scozzafava A, McKenna R, Rossello A, Supuran CT. Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms. Journal of Medicinal Chemistry. 55: 9619-29. PMID 23067387 DOI: 10.1021/Jm300878G  0.717
2012 Díaz Torres N, González G, Biswas S, Scott KM, McKenna R. Preliminary X-ray crystallographic analysis of α-carbonic anhydrase from Thiomicrospira crunogena XCL-2. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 1064-6. PMID 22949195 DOI: 10.1107/S1744309112031053  0.375
2012 Fisher SZ, Aggarwal M, Kovalevsky AY, Silverman DN, McKenna R. Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding. Journal of the American Chemical Society. 134: 14726-9. PMID 22928733 DOI: 10.1021/Ja3068098  0.824
2012 Salganik M, Venkatakrishnan B, Bennett A, Lins B, Yarbrough J, Muzyczka N, Agbandje-McKenna M, McKenna R. Evidence for pH-dependent protease activity in the adeno-associated virus capsid. Journal of Virology. 86: 11877-85. PMID 22915820 DOI: 10.1128/Jvi.01717-12  0.552
2012 Aggarwal M, McKenna R. Update on carbonic anhydrase inhibitors: a patent review (2008 - 2011). Expert Opinion On Therapeutic Patents. 22: 903-15. PMID 22788994 DOI: 10.1517/13543776.2012.707646  0.677
2012 Fisher Z, Boone CD, Biswas SM, Venkatakrishnan B, Aggarwal M, Tu C, Agbandje-McKenna M, Silverman D, McKenna R. Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Engineering, Design & Selection : Peds. 25: 347-55. PMID 22691706 DOI: 10.1093/Protein/Gzs027  0.78
2012 Gurda BL, Raupp C, Popa-Wagner R, Naumer M, Olson NH, Ng R, McKenna R, Baker TS, Kleinschmidt JA, Agbandje-McKenna M. Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. Journal of Virology. 86: 7739-51. PMID 22593150 DOI: 10.1128/Jvi.00218-12  0.567
2012 Venkatakrishnan B, Palii ML, Agbandje-McKenna M, McKenna R. Mining the protein data bank to differentiate error from structural variation in clustered static structures: an examination of HIV protease. Viruses. 4: 348-62. PMID 22590675 DOI: 10.3390/V4030348  0.559
2012 DiMattia MA, Nam HJ, Van Vliet K, Mitchell M, Bennett A, Gurda BL, McKenna R, Olson NH, Sinkovits RS, Potter M, Byrne BJ, Aslanidi G, Zolotukhin S, Muzyczka N, Baker TS, et al. Structural insight into the unique properties of adeno-associated virus serotype 9. Journal of Virology. 86: 6947-58. PMID 22496238 DOI: 10.1128/Jvi.07232-11  0.583
2012 Tu C, Foster L, Alvarado A, McKenna R, Silverman DN, Frost SC. Role of zinc in catalytic activity of carbonic anhydrase IX. Archives of Biochemistry and Biophysics. 521: 90-4. PMID 22465027 DOI: 10.1016/J.Abb.2012.03.017  0.348
2012 Stridh MH, Alt MD, Wittmann S, Heidtmann H, Aggarwal M, Riederer B, Seidler U, Wennemuth G, McKenna R, Deitmer JW, Becker HM. Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II. The Journal of Physiology. 590: 2333-51. PMID 22451434 DOI: 10.1113/Jphysiol.2011.220152  0.67
2012 Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Masini E, Supuran CT. Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo. Journal of Medicinal Chemistry. 55: 1721-30. PMID 22276570 DOI: 10.1021/Jm300031J  0.728
2012 Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Supuran CT. Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. Chemical Communications (Cambridge, England). 48: 1868-70. PMID 22218610 DOI: 10.1039/C2Cc16395K  0.706
2011 Schueler C, Becker HM, McKenna R, Deitmer JW. Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase. Plos One. 6: e27167. PMID 22076132 DOI: 10.1371/Journal.Pone.0027167  0.321
2011 Mikulski R, Domsic JF, Ling G, Tu C, Robbins AH, Silverman DN, McKenna R. Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5. Archives of Biochemistry and Biophysics. 516: 97-102. PMID 22001224 DOI: 10.1016/J.Abb.2011.09.011  0.8
2011 Fisher Z, Kovalevsky AY, Mustyakimov M, Silverman DN, McKenna R, Langan P. Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network "switch" is observed between pH 7.8 and 10.0. Biochemistry. 50: 9421-3. PMID 21988105 DOI: 10.1021/Bi201487B  0.403
2011 Nam HJ, Gurda BL, McKenna R, Potter M, Byrne B, Salganik M, Muzyczka N, Agbandje-McKenna M. Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking. Journal of Virology. 85: 11791-9. PMID 21900159 DOI: 10.1128/Jvi.05305-11  0.566
2011 Biswas S, Aggarwal M, Güzel Ö, Scozzafava A, McKenna R, Supuran CT. Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms. Bioorganic & Medicinal Chemistry. 19: 3732-8. PMID 21620713 DOI: 10.1016/J.Bmc.2011.05.006  0.751
2011 Carta F, Garaj V, Maresca A, Wagner J, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT. Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry. 19: 3105-19. PMID 21515057 DOI: 10.1016/J.Bmc.2011.04.005  0.792
2011 Hen N, Bialer M, Yagen B, Maresca A, Aggarwal M, Robbins AH, McKenna R, Scozzafava A, Supuran CT. Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV. Journal of Medicinal Chemistry. 54: 3977-81. PMID 21506569 DOI: 10.1021/Jm200209N  0.721
2011 Maupin CM, Castillo N, Taraphder S, Tu C, McKenna R, Silverman DN, Voth GA. Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II. Journal of the American Chemical Society. 133: 6223-34. PMID 21452838 DOI: 10.1021/Ja1097594  0.403
2011 Weise A, Schneider HP, McKenna R, Deitmer JW. Substrate-dependent interference of carbonic anhydrases with the glutamine transporter SNAT3-induced conductance Cellular Physiology and Biochemistry. 27: 79-90. PMID 21325825 DOI: 10.1159/000325208  0.352
2011 Becker HM, Klier M, Schüler C, McKenna R, Deitmer JW. Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II Proceedings of the National Academy of Sciences of the United States of America. 108: 3071-3076. PMID 21282642 DOI: 10.1073/Pnas.1014293108  0.364
2011 Mikulski R, Avvaru BS, Tu C, Case N, McKenna R, Silverman DN. Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II. Archives of Biochemistry and Biophysics. 506: 181-7. PMID 21145876 DOI: 10.1016/J.Abb.2010.12.004  0.813
2011 Sippel KH, Venkatakrishnan B, Boehlein SK, Sankaran B, Quirit JG, Govindasamy L, Agbandje-McKenna M, Goodison S, Rosser CJ, McKenna R. Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein. Proteins. 79: 528-36. PMID 21117240 DOI: 10.1002/Prot.22900  0.794
2011 H. Sippel K, Stander A, Tu C, Venkatakrishnan B, H. Robbins A, Agbandje-McKenna M, Joubert F, M. Joubert A, McKenna R. Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds Letters in Drug Design & Discovery. 8: 678-684. DOI: 10.2174/157018011796576105  0.503
2010 Fisher SZ, Kovalevsky AY, Domsic J, Mustyakimov M, Silverman DN, McKenna R, Langan P. Enzymes for carbon sequestration: neutron crystallographic studies of carbonic anhydrase. Acta Crystallographica. Section D, Biological Crystallography. 66: 1178-83. PMID 21041933 DOI: 10.1107/S0907444910019700  0.813
2010 Sippel KH, Genis C, Govindasamy L, Agbandje-McKenna M, Kiddle JJ, Tripp BC, McKenna R. Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II. The Journal of Physical Chemistry Letters. 1: 2898-2902. PMID 20976122 DOI: 10.1021/Jz100954H  0.823
2010 Pacchiano F, Aggarwal M, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT. Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency. Chemical Communications (Cambridge, England). 46: 8371-3. PMID 20922253 DOI: 10.1039/C0Cc02707C  0.82
2010 Ng R, Govindasamy L, Gurda BL, McKenna R, Kozyreva OG, Samulski RJ, Parent KN, Baker TS, Agbandje-McKenna M. Structural characterization of the dual glycan binding adeno-associated virus serotype 6. Journal of Virology. 84: 12945-57. PMID 20861247 DOI: 10.1128/Jvi.01235-10  0.587
2010 Robbins AH, Domsic JF, Agbandje-McKenna M, McKenna R. Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis. Acta Crystallographica. Section D, Biological Crystallography. 66: 950-2. PMID 20693695 DOI: 10.1107/S0907444910023723  0.806
2010 Avvaru BS, Arenas DJ, Tu C, Tanner DB, McKenna R, Silverman DN. Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II. Archives of Biochemistry and Biophysics. 502: 53-9. PMID 20637176 DOI: 10.1016/J.Abb.2010.07.010  0.794
2010 Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R. Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 4376-81. PMID 20605094 DOI: 10.1016/J.Bmcl.2010.06.082  0.814
2010 Wagner J, Avvaru BS, Robbins AH, Scozzafava A, Supuran CT, McKenna R. Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations. Bioorganic & Medicinal Chemistry. 18: 4873-8. PMID 20598552 DOI: 10.1016/J.Bmc.2010.06.028  0.799
2010 Domsic JF, Williams W, Fisher SZ, Tu C, Agbandje-McKenna M, Silverman DN, McKenna R. Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry. 49: 6394-9. PMID 20578724 DOI: 10.1021/Bi1007645  0.816
2010 Robbins AH, Domsic JF, Agbandje-McKenna M, McKenna R. Structure of a monoclinic polymorph of human carbonic anhydrase II with a doubled a axis. Acta Crystallographica. Section D, Biological Crystallography. 66: 628-34. PMID 20445238 DOI: 10.1107/S0907444910006797  0.812
2010 Gurda BL, Parent KN, Bladek H, Sinkovits RS, DiMattia MA, Rence C, Castro A, McKenna R, Olson N, Brown K, Baker TS, Agbandje-McKenna M. Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae. Journal of Virology. 84: 5880-9. PMID 20375175 DOI: 10.1128/Jvi.02719-09  0.583
2010 Robbins AH, Coman RM, Bracho-Sanchez E, Fernandez MA, Gilliland CT, Li M, Agbandje-McKenna M, Wlodawer A, Dunn BM, McKenna R. Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes. Acta Crystallographica. Section D, Biological Crystallography. 66: 233-42. PMID 20179334 DOI: 10.1107/S0907444909054298  0.569
2010 Fisher SZ, Kovalevsky AY, Domsic JF, Mustyakimov M, McKenna R, Silverman DN, Langan PA. Neutron structure of human carbonic anhydrase II: implications for proton transfer. Biochemistry. 49: 415-21. PMID 20025241 DOI: 10.1021/Bi901995N  0.808
2010 Avvaru BS, Kim CU, Sippel KH, Gruner SM, Agbandje-McKenna M, Silverman DN, McKenna R. A short, strong hydrogen bond in the active site of human carbonic anhydrase II. Biochemistry. 49: 249-51. PMID 20000378 DOI: 10.1021/Bi902007B  0.814
2010 Domsic JF, McKenna R. Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases. Biochimica Et Biophysica Acta. 1804: 326-31. PMID 19679198 DOI: 10.1016/J.Bbapap.2009.07.025  0.783
2010 MCKENNA R, NEIDLE S, SERAFINOWSKI P. ChemInform Abstract: Structure of 5′-Chloro-3′,5′-dideoxyformycin A Monohydrate. The Effects of Protonation on Formycin Structure and Conformation. Cheminform. 22: no-no. DOI: 10.1002/chin.199114301  0.432
2009 Sippel KH, Robbins AH, Domsic J, Genis C, Agbandje-McKenna M, McKenna R. High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 992-5. PMID 19851004 DOI: 10.1107/S1744309109036665  0.827
2009 Sippel KH, Boehlein SK, Sakai Y, Quirit JG, Agbandje-McKenna M, Rosser CJ, McKenna R. Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 910-2. PMID 19724130 DOI: 10.1107/S1744309109030565  0.793
2009 Maupin CM, Zheng J, Tu C, McKenna R, Silverman DN, Voth GA. Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II. Biochemistry. 48: 7996-8005. PMID 19634894 DOI: 10.1021/Bi901037U  0.374
2009 Avvaru BS, Busby SA, Chalmers MJ, Griffin PR, Venkatakrishnan B, Agbandje-McKenna M, Silverman DN, McKenna R. Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. Biochemistry. 48: 7365-72. PMID 19583303 DOI: 10.1021/Bi9007512  0.819
2009 Mitchell M, Nam HJ, Carter A, McCall A, Rence C, Bennett A, Gurda B, McKenna R, Porter M, Sakai Y, Byrne BJ, Muzyczka N, Aslanidi G, Zolotukhin S, Agbandje-McKenna M. Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 715-8. PMID 19574648 DOI: 10.1107/S1744309109021460  0.575
2009 Maupin CM, McKenna R, Silverman DN, Voth GA. Elucidation of the proton transport mechanism in human carbonic anhydrase II. Journal of the American Chemical Society. 131: 7598-608. PMID 19438233 DOI: 10.1021/Ja8091938  0.366
2009 Fisher SZ, Kovalevsky AY, Domsic JF, Mustyakimov M, Silverman DN, McKenna R, Langan P. Preliminary joint neutron and X-ray crystallographic study of human carbonic anhydrase II. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 495-8. PMID 19407386 DOI: 10.1107/S1744309109013086  0.811
2009 Liu P, Marzahn MR, Robbins AH, Gutiérrez-de-Terán H, Rodríguez D, McClung SH, Stevens SM, Yowell CA, Dame JB, McKenna R, Dunn BM. Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis. Biochemistry. 48: 4086-99. PMID 19271776 DOI: 10.1021/Bi802059R  0.362
2009 Robbins AH, Dunn BM, Agbandje-McKenna M, McKenna R. Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank. Acta Crystallographica. Section D, Biological Crystallography. 65: 294-6. PMID 19237752 DOI: 10.1107/S0907444908041632  0.577
2009 Sippel KH, Robbins AH, Reutzel R, Boehlein SK, Namiki K, Goodison S, Agbandje-McKenna M, Rosser CJ, McKenna R. Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis. Journal of Bacteriology. 191: 2585-92. PMID 19233924 DOI: 10.1128/Jb.01680-08  0.793
2009 Genis C, Sippel KH, Case N, Cao W, Avvaru BS, Tartaglia LJ, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Rosser CJ, McKenna R. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry. 48: 1322-31. PMID 19170619 DOI: 10.1021/Bi802035F  0.806
2009 Levy HC, Bowman VD, Govindasamy L, McKenna R, Nash K, Warrington K, Chen W, Muzyczka N, Yan X, Baker TS, Agbandje-McKenna M. Heparin binding induces conformational changes in Adeno-associated virus serotype 2. Journal of Structural Biology. 165: 146-56. PMID 19121398 DOI: 10.1016/J.Jsb.2008.12.002  0.577
2008 Sippel KH, Robbins AH, Reutzel R, Domsic J, Boehlein SK, Govindasamy L, Agbandje-McKenna M, Rosser CJ, McKenna R. Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37. Acta Crystallographica. Section D, Biological Crystallography. 64: 1172-8. PMID 19020356 DOI: 10.1107/S0907444908030175  0.788
2008 Zheng J, Avvaru BS, Tu C, McKenna R, Silverman DN. Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II. Biochemistry. 47: 12028-36. PMID 18942852 DOI: 10.1021/Bi801473W  0.809
2008 Pepin KM, Domsic J, McKenna R. Genomic evolution in a virus under specific selection for host recognition. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 8: 825-34. PMID 18804189 DOI: 10.1016/J.Meegid.2008.08.008  0.742
2008 Domsic JF, Avvaru BS, Kim CU, Gruner SM, Agbandje-McKenna M, Silverman DN, McKenna R. Entrapment of carbon dioxide in the active site of carbonic anhydrase II. The Journal of Biological Chemistry. 283: 30766-71. PMID 18768466 DOI: 10.1074/Jbc.M805353200  0.811
2008 Maupin CM, Saunders MG, Thorpe IF, McKenna R, Silverman DN, Voth GA. Origins of enhanced proton transport in the Y7F mutant of human carbonic anhydrase II. Journal of the American Chemical Society. 130: 11399-408. PMID 18671353 DOI: 10.1021/Ja802264J  0.371
2008 Coman RM, Robbins AH, Goodenow MM, Dunn BM, McKenna R. High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance. Acta Crystallographica. Section D, Biological Crystallography. 754-63. PMID 18566511 DOI: 10.1107/S090744490801278X  0.352
2008 Quint PS, Domsic JF, Cabelli DE, McKenna R, Silverman DN. Role of a glutamate bridge spanning the dimeric interface of human manganese superoxide dismutase. Biochemistry. 47: 4621-8. PMID 18373354 DOI: 10.1021/Bi7024518  0.774
2008 Barrese AA, Genis C, Fisher SZ, Orwenyo JN, Kumara MT, Dutta SK, Phillips E, Kiddle JJ, Tu C, Silverman DN, Govindasamy L, Agbandje-McKenna M, McKenna R, Tripp BC. Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry. 47: 3174-84. PMID 18266323 DOI: 10.1021/Bi702385K  0.633
2008 Clemente JC, Robbins A, Graña P, Paleo MR, Correa JF, Villaverde MC, Sardina FJ, Govindasamy L, Agbandje-McKenna M, McKenna R, Dunn BM, Sussman F. Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation. Journal of Medicinal Chemistry. 51: 852-60. PMID 18215016 DOI: 10.1021/Jm701170F  0.543
2008 Andersen FF, Knudsen B, Oliveira CL, Frøhlich RF, Krüger D, Bungert J, Agbandje-McKenna M, McKenna R, Juul S, Veigaard C, Koch J, Rubinstein JL, Guldbrandtsen B, Hede MS, Karlsson G, et al. Assembly and structural analysis of a covalently closed nano-scale DNA cage. Nucleic Acids Research. 36: 1113-9. PMID 18096620 DOI: 10.1093/Nar/Gkm1124  0.536
2008 Bennett A, McKenna R, Agbandje-McKenna M. A Comparative Analysis of the Structural Architecture of ssDNA Viruses Computational and Mathematical Methods in Medicine. 9: 183-196. DOI: 10.1080/17486700802168247  0.541
2007 Quesada O, Gurda B, Govindasamy L, McKenna R, Kohlbrenner E, Aslanidi G, Zolotukhin S, Muzyczka N, Agbandje-McKenna M. Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 1073-6. PMID 18084098 DOI: 10.1107/S1744309107060289  0.558
2007 Zheng J, Domsic JF, Cabelli D, McKenna R, Silverman DN. Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases. Biochemistry. 46: 14830-7. PMID 18044968 DOI: 10.1021/Bi7014103  0.77
2007 Sabo-Attwood T, Blum JL, Kroll KJ, Patel V, Birkholz D, Szabo NJ, Fisher SZ, McKenna R, Campbell-Thompson M, Denslow ND. Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol. Journal of Molecular Endocrinology. 39: 223-37. PMID 17909263 DOI: 10.1677/Jme-07-0038  0.638
2007 Nam HJ, Lane MD, Padron E, Gurda B, McKenna R, Kohlbrenner E, Aslanidi G, Byrne B, Muzyczka N, Zolotukhin S, Agbandje-McKenna M. Structure of adeno-associated virus serotype 8, a gene therapy vector. Journal of Virology. 81: 12260-71. PMID 17728238 DOI: 10.1128/Jvi.01304-07  0.58
2007 Silverman DN, McKenna R. Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Accounts of Chemical Research. 40: 669-75. PMID 17550224 DOI: 10.1021/Ar7000588  0.395
2007 Elder I, Fisher Z, Laipis PJ, Tu C, McKenna R, Silverman DN. Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III. Proteins. 68: 337-43. PMID 17427958 DOI: 10.1002/Prot.21403  0.459
2007 Coman RM, Robbins A, Goodenow MM, McKenna R, Dunn BM. Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 320-3. PMID 17401206 DOI: 10.1107/S174430910701161X  0.359
2007 Fisher SZ, Tu C, Bhatt D, Govindasamy L, Agbandje-McKenna M, McKenna R, Silverman DN. Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II. Biochemistry. 46: 3803-13. PMID 17330962 DOI: 10.1021/Bi602620K  0.821
2007 Fisher SZ, Maupin CM, Budayova-Spano M, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Voth GA, McKenna R. Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism. Biochemistry. 46: 2930-7. PMID 17319692 DOI: 10.1021/Bi062066Y  0.795
2007 Bhatt D, Fisher SZ, Tu C, McKenna R, Silverman DN. Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophysical Journal. 92: 562-70. PMID 17071654 DOI: 10.1529/Biophysj.106.093203  0.736
2006 Miller EB, Gurda-Whitaker B, Govindasamy L, McKenna R, Zolotukhin S, Muzyczka N, Agbandje-McKenna M. Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1271-4. PMID 17142915 DOI: 10.1107/S1744309106048184  0.572
2006 Govindasamy L, Padron E, McKenna R, Muzyczka N, Kaludov N, Chiorini JA, Agbandje-McKenna M. Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. Journal of Virology. 80: 11556-70. PMID 16971437 DOI: 10.1128/Jvi.01536-06  0.597
2006 Fisher SZ, Tariku I, Case NM, Tu C, Seron T, Silverman DN, Linser PJ, McKenna R. Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1). Biochimica Et Biophysica Acta. 1764: 1413-9. PMID 16920039 DOI: 10.1016/J.Bbapap.2006.06.013  0.731
2006 Nam HJ, Gurda-Whitaker B, Wand YG, Ilaria S, McKenna R, Mehta P, Alvarez RA, Agbandje-McKenna M. Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation Journal of Biological Chemistry. 281: 25670-25677. PMID 16822863 DOI: 10.1074/Jbc.M604421200  0.573
2006 Fisher SZ, Govindasamy L, Boyle N, Agbandje-McKenna M, Silverman DN, Blackburn GM, McKenna R. X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 618-22. PMID 16820676 DOI: 10.1107/S1744309106020446  0.783
2006 Clemente JC, Coman RM, Thiaville MM, Janka LK, Jeung JA, Nukoolkarn S, Govindasamy L, Agbandje-McKenna M, McKenna R, Leelamanit W, Goodenow MM, Dunn BM. Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir. Biochemistry. 45: 5468-77. PMID 16634628 DOI: 10.1021/Bi051886S  0.545
2006 Fisher SZ, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Rajaniemi HJ, McKenna R. Structure of human salivary alpha-amylase crystallized in a C-centered monoclinic space group. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 88-93. PMID 16511271 DOI: 10.1107/S1744309105042491  0.773
2006 Budayova-Spano M, Fisher SZ, Dauvergne MT, Agbandje-McKenna M, Silverman DN, Myles DA, McKenna R. Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 6-9. PMID 16511248 DOI: 10.1107/S1744309105038248  0.796
2006 Clemente JC, Govindasamy L, Madabushi A, Fisher SZ, Moose RE, Yowell CA, Hidaka K, Kimura T, Hayashi Y, Kiso Y, Agbandje-McKenna M, Dame JB, Dunn BM, McKenna R. Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. Acta Crystallographica. Section D, Biological Crystallography. 62: 246-52. PMID 16510971 DOI: 10.1107/S0907444905041260  0.759
2006 Quint P, Reutzel R, Mikulski R, McKenna R, Silverman DN. Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation. Free Radical Biology & Medicine. 40: 453-8. PMID 16443160 DOI: 10.1016/J.Freeradbiomed.2005.08.045  0.81
2006 López-Bueno A, Rubio M, Bryant N, McKenna R, Agbandje-McKenna M, Almendral JM. Host-Selected Amino Acid Changes at the Sialic Acid Binding Pocket of the Parvovirus Capsid Modulate Cell Binding Affinity and Determine Virulence Journal of Virology. 80: 1563-1573. PMID 16415031 DOI: 10.1128/Jvi.80.3.1563-1573.2006  0.573
2005 DiMattia M, Govindasamy L, Levy HC, Gurda-Whitaker B, Kalina A, Kohlbrenner E, Chiorini JA, McKenna R, Muzyczka N, Zolotukhin S, Agbandje-McKenna M. Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 917-21. PMID 16511195 DOI: 10.1107/S1744309105028514  0.577
2005 Lane MD, Nam HJ, Padron E, Gurda-Whitaker B, Kohlbrenner E, Aslanidi G, Byrne B, McKenna R, Muzyczka N, Zolotukhin S, Agbandje-McKenna M. Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 558-61. PMID 16511095 DOI: 10.1107/S1744309105014132  0.575
2005 Madabushi A, Chakraborty S, Fisher SZ, Clemente JC, Yowell C, Agbandje-McKenna M, Dame JB, Dunn BM, McKenna R. Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 228-31. PMID 16511002 DOI: 10.1107/S1744309105001405  0.751
2005 Bhatt D, Tu C, Fisher SZ, Hernandez Prada JA, McKenna R, Silverman DN. Proton transfer in a Thr200His mutant of human carbonic anhydrase II. Proteins. 61: 239-45. PMID 16106378 DOI: 10.1002/Prot.20615  0.716
2005 Kontou M, Govindasamy L, Nam HJ, Bryant N, Llamas-Saiz AL, Foces-Foces C, Hernando E, Rubio MP, McKenna R, Almendral JM, Agbandje-McKenna M. Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice Journal of Virology. 79: 10931-10943. PMID 16103145 DOI: 10.1128/Jvi.79.17.10931-10943.2005  0.571
2005 Duda DM, Tu C, Fisher SZ, An H, Yoshioka C, Govindasamy L, Laipis PJ, Agbandje-McKenna M, Silverman DN, McKenna R. Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer. Biochemistry. 44: 10046-53. PMID 16042381 DOI: 10.1021/Bi050610H  0.83
2005 Ketcham CM, Anai S, Reutzel R, Sheng S, Schuster SM, Brenes RB, Agbandje-McKenna M, McKenna R, Rosser CJ, Boehlein SK. p37 Induces tumor invasiveness. Molecular Cancer Therapeutics. 4: 1031-8. PMID 16020660 DOI: 10.1158/1535-7163.Mct-05-0040  0.778
2005 Elder I, Tu C, Ming LJ, McKenna R, Silverman DN. Proton transfer from exogenous donors in catalysis by human carbonic anhydrase II. Archives of Biochemistry and Biophysics. 437: 106-14. PMID 15820222 DOI: 10.1016/J.Abb.2005.03.001  0.392
2005 Padron E, Bowman V, Kaludov N, Govindasamy L, Levy H, Nick P, McKenna R, Muzyczka N, Chiorini JA, Baker TS, Agbandje-McKenna M. Structure of adeno-associated virus type 4. Journal of Virology. 79: 5047-58. PMID 15795290 DOI: 10.1128/Jvi.79.8.5047-5058.2005  0.577
2005 Beyer BB, Johnson JV, Chung AY, Li T, Madabushi A, Agbandje-McKenna M, McKenna R, Dame JB, Dunn BM. Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries. Biochemistry. 44: 1768-79. PMID 15697202 DOI: 10.1021/Bi047886U  0.53
2005 Fisher Z, Hernandez Prada JA, Tu C, Duda D, Yoshioka C, An H, Govindasamy L, Silverman DN, McKenna R. Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II. Biochemistry. 44: 1097-105. PMID 15667203 DOI: 10.1021/Bi0480279  0.759
2004 Govindasamy L, Pedersen B, Lian W, Kukar T, Gu Y, Jin S, Agbandje-McKenna M, Wu D, McKenna R. Structural insights and functional implications of choline acetyltransferase. Journal of Structural Biology. 148: 226-35. PMID 15477102 DOI: 10.1016/J.Jsb.2004.06.005  0.584
2004 Clemente JC, Moose RE, Hemrajani R, Whitford LR, Govindasamy L, Reutzel R, McKenna R, Agbandje-McKenna M, Goodenow MM, Dunn BM. Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease. Biochemistry. 43: 12141-51. PMID 15379553 DOI: 10.1021/bi049459m  0.785
2004 Casado CG, Ortiz GJ, Padron E, Bean SJ, McKenna R, Agbandje-McKenna M, Boulton MI. Isolation and characterization of subgenomic DNAs encapsidated in "single" T = 1 isometric particles of Maize streak virus Virology. 323: 164-171. PMID 15165828 DOI: 10.1016/J.Virol.2004.02.014  0.487
2004 Govindasamy L, Reutzel R, Agbandje-McKenna M, McKenna R. Structural determination of a partially hemihedrally twinned actin crystal. Acta Crystallographica Section D-Biological Crystallography. 60: 1040-1047. PMID 15159563 DOI: 10.1107/S0907444904006948  0.793
2004 Govindasamy L, Kukar T, Lian W, Pedersen B, Gu Y, Agbandje-McKenna M, Jin S, McKenna R, Wu D. Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. Journal of Structural Biology. 146: 416-24. PMID 15099582 DOI: 10.1016/J.Jsb.2004.01.011  0.583
2004 Reutzel R, Yoshioka C, Govindasamy L, Yarmola EG, Agbandje-McKenna M, Bubb MR, McKenna R. Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer. Journal of Structural Biology. 146: 291-301. PMID 15099571 DOI: 10.1016/J.Jsb.2003.12.006  0.779
2004 Lian W, Gu Y, Pedersen B, Kukar T, Govindasamy L, Agbandje-McKenna M, Jin S, McKenna R, Wu D. Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase. Acta Crystallographica. Section D, Biological Crystallography. 60: 374-5. PMID 14747730 DOI: 10.1107/S090744490302818X  0.523
2003 Gumz ML, Duda D, McKenna R, Wingo CS, Cain BD. Molecular modeling of the rabbit colonic (HKα2a) H+, K+ ATPase Journal of Molecular Modeling. 9: 283-289. PMID 12884085 DOI: 10.1007/S00894-003-0140-2  0.713
2003 Kaludov N, Padron E, Govindasamy L, McKenna R, Chiorini JA, Agbandje-McKenna M. Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4 Virology. 306: 1-6. PMID 12620791 DOI: 10.1016/S0042-6822(02)00037-5  0.561
2003 Wu D, Govindasamy L, Lian W, Gu Y, Kukar T, Agbandje-McKenna M, McKenna R. Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. The Journal of Biological Chemistry. 278: 13159-65. PMID 12562770 DOI: 10.1074/Jbc.M212356200  0.602
2003 Duda D, Govindasamy L, Agbandje-McKenna M, Tu C, Silverman DN, McKenna R. The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer. Acta Crystallographica. Section D, Biological Crystallography. 59: 93-104. PMID 12499545 DOI: 10.1107/S0907444902019455  0.79
2002 Reutzel R, Boehlein SK, Govindasamy L, Brenes RB, Agbandje-Mckenna M, Schuster SM, Mckenna R. Crystallization and preliminary X-ray analysis of the tumor metastasis factor p37. Acta Crystallographica Section D-Biological Crystallography. 58: 2141-2144. PMID 12454480 DOI: 10.1107/S0907444902015536  0.8
2002 Tu C, Qian M, An H, Wadhwa NR, Duda D, Yoshioka C, Pathak Y, McKenna R, Laipis PJ, Silverman DN. Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase. The Journal of Biological Chemistry. 277: 38870-6. PMID 12171926 DOI: 10.1074/Jbc.M205791200  0.75
2002 Lian W, Govindasamy L, Gu Y, Kukar T, Agbandje-McKenna M, McKenna R, Wu D. Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase. Acta Crystallographica. Section D, Biological Crystallography. 58: 1193-4. PMID 12077440 DOI: 10.1107/S0907444902005498  0.562
2002 Duda DM, Yoshioka C, Govindasamy L, An H, Tu C, Silverman DN, McKenna R. Crystallization and preliminary X-ray analysis of human carbonic anhydrase III. Acta Crystallographica. Section D, Biological Crystallography. 58: 849-52. PMID 11976500 DOI: 10.1107/S0907444902003700  0.734
2002 Bubb MR, Govindasamy L, Yarmola EG, Vorobiev SM, Almo SC, Somasundaram T, Chapman MS, Agbandje-McKenna M, McKenna R. Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution. The Journal of Biological Chemistry. 277: 20999-1006. PMID 11932258 DOI: 10.1074/Jbc.M201371200  0.544
2002 An H, Tu C, Duda D, Montanez-Clemente I, Math K, Laipis PJ, McKenna R, Silverman DN. Chemical rescue in catalysis by human carbonic anhydrases II and III. Biochemistry. 41: 3235-42. PMID 11863462 DOI: 10.1021/Bi0120695  0.746
2002 Brentlinger KL, Hafenstein S, Novak CR, Fane BA, Borgon R, McKenna R, Agbandje-McKenna M. Microviridae, a family divided: isolation, characterization, and genome sequence of phiMH2K, a bacteriophage of the obligate intracellular parasitic bacterium Bdellovibrio bacteriovorus. Journal of Bacteriology. 184: 1089-94. PMID 11807069 DOI: 10.1128/Jb.184.4.1089-1094.2002  0.508
2001 Bloom ME, Best SM, Hayes SF, Wells RD, Wolfinbarger JB, McKenna R, Agbandje-McKenna M. Identification of aleutian mink disease parvovirus capsid sequences mediating antibody-dependent enhancement of infection, virus neutralization, and immune complex formation. Journal of Virology. 75: 11116-27. PMID 11602751 DOI: 10.1128/Jvi.75.22.11116-11127.2001  0.514
2001 Duda D, Tu C, Qian M, Laipis P, Agbandje-McKenna M, Silverman DN, McKenna R. Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II. Biochemistry. 40: 1741-8. PMID 11327835 DOI: 10.1021/Bi002295Z  0.793
2001 Duda D, Tu C, Silverman D, Kalb (Gilboa) A, Agbandje-McKenna M, McKenna R. Ultra-High Resolution X-Ray Diffraction From Crystals Of The Kinetic Mutant Of Human Carbonic Anhydrase Ii, His 64 Ala, And Its Complexes With Proton Acceptor Donors. Protein & Peptide Letters. 8: 63-67. DOI: 10.2174/0929866013409751  0.794
2000 Bennett M, Krah A, Wien F, Garman E, McKenna R, Sanderson M, Neidle S. A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling. Proceedings of the National Academy of Sciences of the United States of America. 97: 9476-81. PMID 10920199 DOI: 10.1073/Pnas.160271897  0.705
2000 Hernando E, Llamas-Saiz AL, Foces-Foces C, McKenna R, Portman I, Agbandje-McKenna M, Almendral JM. Biochemical and Physical Characterization of Parvovirus Minute Virus of Mice Virus-like Particles Virology. 267: 299-309. PMID 10662625 DOI: 10.1006/Viro.1999.0123  0.55
1999 McKenna R, Olson NH, Chipman PR, Baker TS, Booth TF, Christensen J, Aasted B, Fox JM, Bloom ME, Wolfinbarger JB, Agbandje-McKenna M. Three-dimensional structure of Aleutian mink disease parvovirus: implications for disease pathogenicity. Journal of Virology. 73: 6882-91. PMID 10400786 DOI: 10.1128/Jvi.73.8.6882-6891.1999  0.56
1998 Dokland T, McKenna R, Sherman DM, Bowman BR, Bean WF, Rossmann MG. Structure determination of the phiX174 closed procapsid. Acta Crystallographica. Section D, Biological Crystallography. 54: 878-90. PMID 9757104 DOI: 10.1107/S0907444998002467  0.35
1998 Chipman PR, Agbandje-McKenna M, Renaudin J, Baker TS, McKenna R. Structural analysis of the spiroplasma virus, SpV4: Implications for evolutionary variation to obtain host diversity among the Microviridae Structure. 6: 135-145. PMID 9519405 DOI: 10.1016/S0969-2126(98)00016-1  0.583
1997 Olson NH, Chipman PR, Bloom ME, McKenna R, Agbandje-McKenna M, Booth TF, Baker TS. Automated CCD Data Collection and 3D Reconstruction of Aleutian Mink Disease Parvovirus Microscopy and Microanalysis. 3: 1117-1118. DOI: 10.1017/S1431927600012472  0.468
1994 Agbandje M, Kajigaya S, McKenna R, Young NS, Rossmann MG. The structure of human parvovirus B19 at 8 A resolution. Virology. 203: 106-15. PMID 8030266 DOI: 10.1006/Viro.1994.1460  0.362
1994 Ilag LL, McKenna R, Yadav MP, BeMiller JN, Incardona NL, Rossmann MG. Calcium ion-induced structural changes in bacteriophage phi X174. Journal of Molecular Biology. 244: 291-300. PMID 7966340 DOI: 10.1006/Jmbi.1994.1730  0.393
1992 Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. Journal of Medicinal Chemistry. 35: 1418-29. PMID 1573635 DOI: 10.1021/Jm00086A010  0.475
1992 McKenna R, Agbandje M, Neidle S. Structure of 9-amino-2,7-di-tert-butylacridine Acta Crystallographica Section C Crystal Structure Communications. 48: 188-190. DOI: 10.1107/S0108270191009113  0.449
1992 Rossmann MG, McKenna R, Tong L, Xia D, Dai J, Wu H, Choi HK, Lynch RE. Molecular replacement real-space averaging Journal of Applied Crystallography. 25: 166-180. DOI: 10.1107/S002188989101141X  0.317
1991 McKenna R, Neidle S, Wilson WD. Structures of 1-(3,3-dimethylamino)propyl naphtho[2,1-b]thiophene-4- carboxylate and N-(3,3-dimethylamino)propyl-8-methoxynaphtho[2,1- b]thiophene-4-carboxamide, intercalators into double-helical DNA. Acta Crystallographica. Section C, Crystal Structure Communications. 47: 2511-3. PMID 1805872 DOI: 10.1107/S0108270191005991  0.376
1990 Laughton CA, McKenna R, Neidle S, Jarman M, McCague R, Rowlands MG. Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives. Journal of Medicinal Chemistry. 33: 2673-9. PMID 2391706 DOI: 10.1021/Jm00171A052  0.516
1990 McKenna R, Neidle S, Serafinowski P. Structure of 5'-chloro-3',5'-dideoxyformycin A monohydrate. The effects of protonation on formycin structure and conformation Acta Crystallographica Section C Crystal Structure Communications. 46: 2448-2450. DOI: 10.1107/S0108270190010630  0.45
1989 McKenna R, Beveridge AJ, Jenkins TC, Neidle S, Denny WA. Molecular modelling of DNA-antitumour drug intercalation interactions: correlation of structural and energetic features with biological properties for a series of phenylquinoline-8-carboxamide compounds. Molecular Pharmacology. 35: 720-8. PMID 2725476  0.402
1989 McKenna R, Neidle S, Kuroda R, Fox BW. Structures of three DNA cross-linking agents, ethane-1,2-di(methylsulfonate), propane-1,3-di(methylsulfonate) and n-butane-1,4-di(methylsulfonate). Acta Crystallographica. Section C, Crystal Structure Communications. 45: 311-4. PMID 2558689 DOI: 10.1107/S0108270188011291  0.446
1989 Deadman JJ, Jarman M, McCague R, McKenna R, Neidle S. A benzoquinone Di-imine from the oxidation of pentafluoroaniline by hypochlorite. X-Ray crystal structure and possible formation via pentafluorophenylnitrene Journal of the Chemical Society-Perkin Transactions 1. 971-975. DOI: 10.1039/P29890000971  0.499
1989 DEADMAN JJ, JARMAN M, MCCAGUE R, MCKENNA R, NEIDLE S. ChemInform Abstract: A Benzoquinone Diimine from the Oxidation of Pentafluoroaniline by Hypochlorite. X-Ray Crystal Structure and Possible Formation via Pentafluorophenylnitrene. Cheminform. 20. DOI: 10.1002/chin.198947152  0.428
1988 McKenna R, Jenkins TC, Neidle S. Structures of the anticancer compounds N-(2-hydroxyethyl)-2-(3-nitro-1,2,4-triazol-1-yl)-acetamide (RB-6110) and 5-(1-aziridinyl)-3-nitro-1-(3-oxo-1-butyl)-1,2,4- triazole (RB-6162). Acta Crystallographica. Section B, Structural Science. 44: 672-6. PMID 3271560  0.375
1987 McKenna R, Kuroda R, Neidle S, Serafinowski P. A structural study of 3'-deoxytubercidin and 3-deaza-3'-deoxyadenosine Acta Crystallographica Section C Crystal Structure Communications. 43: 1790-1793. DOI: 10.1107/S0108270187090164  0.503
1987 McKenna R, Neidle S, Serafinowski P. The structure of 3'-deoxyformycin hydrochloride Acta Crystallographica Section C Crystal Structure Communications. 43: 2358-2361. DOI: 10.1107/S0108270187087766  0.499
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