Luiz Augusto Basso - Publications

Biochemistry Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil 

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Rodrigues-Junior VS, Pail PB, Villela AD, Falcão VCA, Dadda AS, Abbadi BL, Pesquero JB, Santos DS, Basso LA, Campos MM. Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice. Tuberculosis (Edinburgh, Scotland). 109: 1-7. PMID 29559112 DOI: 10.1016/  0.36
2017 Amorim CF, Galina L, Carvalho NB, Sperotto NDM, Pissinate K, Machado P, Campos MM, Basso LA, Rodrigues-Junior VS, Carvalho EM, Santos DS. Inhibitory activity of pentacyano(isoniazid)ferrate(II), IQG-607, against promastigotes and amastigotes forms of Leishmania braziliensis. Plos One. 12: e0190294. PMID 29281707 DOI: 10.1371/journal.pone.0190294  0.36
2017 Abbadi BL, Villela AD, Rodrigues-Junior VS, Subtil FT, Dalberto PF, Pinheiro APS, Santos DS, Machado P, Basso LA, Bizarro CV. Revisiting activation of and the mechanism of resistance to the compound IQG-607 in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 29158273 DOI: 10.1128/AAC.02222-17  0.36
2017 Dadda ADS, Rodrigues-Junior VS, Carreño F, Petersen GO, Pinto AFM, Dalberto PF, Sperotto NDM, Pissinate K, Bizarro CV, Machado P, Campos MM, Costa TD, Santos DS, Basso LA. Preclinical pharmacokinetic profiling of IQG-607, a potential oral metallodrug to treat tuberculosis. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29037995 DOI: 10.1016/j.ejps.2017.10.020  0.36
2017 Rotta M, Timmers LFSM, Sequeiros-Borja C, Bizarro CV, de Souza ON, Santos DS, Basso LA. Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only. Scientific Reports. 7: 6826. PMID 28754992 DOI: 10.1038/s41598-017-07266-w  0.36
2017 Timmers LFSM, Neto AMS, Montalvão RW, Basso LA, Santos DS, Norberto de Souza O. EPSP synthase flexibility is determinant to its function: computational molecular dynamics and metadynamics studies. Journal of Molecular Modeling. 23: 197. PMID 28589464 DOI: 10.1007/s00894-017-3372-2  0.36
2017 Martinelli LKB, Rotta M, Villela AD, Rodrigues-Junior VS, Abbadi BL, Trindade RV, Petersen GO, Danesi GM, Nery LR, Pauli I, Campos MM, Bonan CD, de Souza ON, Basso LA, Santos DS. Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme. Scientific Reports. 7: 46696. PMID 28436453 DOI: 10.1038/srep46696  0.36
2017 Rodrigues-Junior VS, Machado P, Calixto JB, Siqueira JM, Andrade E, Bento A, Campos MM, Basso LA, Santos DS. Preclinical safety evaluation of IQG-607 in rats: Acute and repeated dose toxicity studies. Regulatory Toxicology and Pharmacology : Rtp. 86: 11-17. PMID 28232042 DOI: 10.1016/j.yrtph.2017.02.016  0.36
2014 Nicoletti NF, Rodrigues-Junior V, Santos AA, Leite CE, Dias AC, Batista EL, Basso LA, Campos MM, Santos DS, Souto AA. Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation. Journal of Natural Products. 77: 2190-5. PMID 25302422 DOI: 10.1021/np5003143  0.36
2014 Renck D, Santos AA, Machado P, Petersen GO, Lopes TG, Santos DS, Campos MM, Basso LA. Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis. Investigational New Drugs. 32: 1301-7. PMID 25052233 DOI: 10.1007/s10637-014-0135-0  0.36
2014 Marder LS, Lunardi J, Renard G, Rostirolla DC, Petersen GO, Nunes JE, de Souza AP, de O Dias AC, Chies JM, Basso LA, Santos DS, Bizarro CV. Production of recombinant human annexin V by fed-batch cultivation. Bmc Biotechnology. 14: 33. PMID 24766778 DOI: 10.1186/1472-6750-14-33  0.36
2014 Rodrigues-Junior VS, dos Santos Junior AA, Villela AD, Belardinelli JM, Morbidoni HR, Basso LA, Campos MM, Santos DS. IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages. International Journal of Antimicrobial Agents. 43: 82-5. PMID 24139881 DOI: 10.1016/j.ijantimicag.2013.08.021  0.36
2013 Renck D, Machado P, Souto AA, Rosado LA, Erig T, Campos MM, Farias CB, Roesler R, Timmers LF, de Souza ON, Santos DS, Basso LA. Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. Journal of Medicinal Chemistry. 56: 8892-902. PMID 24131420 DOI: 10.1021/jm401389u  0.36
2013 Pauli I, dos Santos RN, Rostirolla DC, Martinelli LK, Ducati RG, Timmers LF, Basso LA, Santos DS, Guido RV, Andricopulo AD, Norberto de Souza O. Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach. Journal of Chemical Information and Modeling. 53: 2390-401. PMID 23889525 DOI: 10.1021/ci400202t  0.36
2013 Jaskulski L, Rosado LA, Rostirolla DC, Timmers LF, de Souza ON, Santos DS, Basso LA. Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase. Archives of Biochemistry and Biophysics. 536: 53-63. PMID 23756762 DOI: 10.1016/  0.36
2012 Rosado LA, Caceres RA, de Azevedo WF, Basso LA, Santos DS. Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA). Bmc Research Notes. 5: 526. PMID 23006410 DOI: 10.1186/1756-0500-5-526  0.36
2012 Breda A, Martinelli LK, Bizarro CV, Rosado LA, Borges CB, Santos DS, Basso LA. Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS? Plos One. 7: e39245. PMID 22745722 DOI: 10.1371/journal.pone.0039245  0.36
2012 Franco TM, Rostirolla DC, Ducati RG, Lorenzini DM, Basso LA, Santos DS. Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC from Mycobacterium tuberculosis H37Rv strain. Archives of Biochemistry and Biophysics. 517: 1-11. PMID 22119138 DOI: 10.1016/  0.36
2012 Caceres RA, Timmers LF, Ducati RG, da Silva DO, Basso LA, de Azevedo WF, Santos DS. Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir. Biochimie. 94: 155-65. PMID 22033138 DOI: 10.1016/j.biochi.2011.10.003  0.36
2011 Nunes JE, Ducati RG, Breda A, Rosado LA, de Souza BM, Palma MS, Santos DS, Basso LA. Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC Archives of Biochemistry and Biophysics. 512: 143-53. PMID 21672513 DOI: 10.1016/  0.36
2011 Sperb F, Werlang IC, Margis-Pinheiro M, Basso LA, Santos DS, Pasquali G. Molecular cloning and transgenic expression of a synthetic human erythropoietin gene in tobacco. Applied Biochemistry and Biotechnology. 165: 652-65. PMID 21590305 DOI: 10.1007/s12010-011-9283-2  0.36
2011 Sánchez-Quitian ZA, Timmers LF, Caceres RA, Rehm JG, Thompson CE, Basso LA, de Azevedo WF, Santos DS. Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products. Archives of Biochemistry and Biophysics. 509: 108-15. PMID 21295009 DOI: 10.1016/  0.36
2011 Rostirolla DC, Breda A, Rosado LA, Palma MS, Basso LA, Santos DS. UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation. Archives of Biochemistry and Biophysics. 505: 202-12. PMID 21035424 DOI: 10.1016/  0.36
2010 Ducati RG, Basso LA, Santos DS, de Azevedo WF. Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry. 18: 4769-74. PMID 20570524 DOI: 10.1016/j.bmc.2010.05.009  0.36
2010 Neto BA, Lapis AA, Mancilha FS, Batista EL, Netz PA, Rominger F, Basso LA, Santos DS, Dupont J. On the selective detection of duplex deoxyribonucleic acids by 2,1,3-benzothiadiazole fluorophores. Molecular Biosystems. 6: 967-75. PMID 20485741 DOI: 10.1039/b919155k  0.36
2010 Renck D, Ducati RG, Palma MS, Santos DS, Basso LA. The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy. Archives of Biochemistry and Biophysics. 497: 35-42. PMID 20226755 DOI: 10.1016/  0.36
2010 Sánchez-Quitian ZA, Schneider CZ, Ducati RG, de Azevedo WF, Bloch C, Basso LA, Santos DS. Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase. Journal of Structural Biology. 169: 413-23. PMID 20035876 DOI: 10.1016/j.jsb.2009.12.019  0.36
2009 Rodrigues VS, Breda A, Santos DS, Basso LA. The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase. Bmc Research Notes. 2: 227. PMID 19917104 DOI: 10.1186/1756-0500-2-227  0.36
2009 Werlang IC, Schneider CZ, Mendonça JD, Palma MS, Basso LA, Santos DS. Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis. Microbiology (Reading, England). 155: 2652-63. PMID 19477901 DOI: 10.1099/mic.0.030148-0  0.36
2009 Ducati RG, Santos DS, Basso LA. Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 486: 155-64. PMID 19416718 DOI: 10.1016/  0.36
2009 Czekster CM, Neto BA, Lapis AA, Dupont J, Santos DS, Basso LA. Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 486: 19-26. PMID 19364491 DOI: 10.1016/  0.36
2009 Biazus G, Schneider CZ, Palma MS, Basso LA, Santos DS. Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization. Protein Expression and Purification. 66: 185-90. PMID 19362594 DOI: 10.1016/j.pep.2009.04.001  0.36
2009 Thum C, Schneider CZ, Palma MS, Santos DS, Basso LA. The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP. Journal of Bacteriology. 191: 2884-7. PMID 19181797 DOI: 10.1128/JB.01337-08  0.36
2008 Ely F, Nunes JE, Schroeder EK, Frazzon J, Palma MS, Santos DS, Basso LA. The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase. Bmc Biochemistry. 9: 13. PMID 18445278 DOI: 10.1186/1471-2091-9-13  0.36
2008 Vanz AL, Renard G, Palma MS, Chies JM, Dalmora SL, Basso LA, Santos DS. Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization. Microbial Cell Factories. 7: 13. PMID 18394164 DOI: 10.1186/1475-2859-7-13  0.36
2008 Arcuri HA, Borges JC, Fonseca IO, Pereira JH, Neto JR, Basso LA, Santos DS, de Azevedo WF. Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis. Proteins. 72: 720-30. PMID 18260104 DOI: 10.1002/prot.21953  0.36
2008 Silva RG, Rosado LA, Santos DS, Basso LA. Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding. Archives of Biochemistry and Biophysics. 471: 1-10. PMID 18155153 DOI: 10.1016/  0.36
2008 Schneider CZ, Parish T, Basso LA, Santos DS. The two chorismate mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis: biochemical analysis and limited regulation of promoter activity by aromatic amino acids. Journal of Bacteriology. 190: 122-34. PMID 17965159 DOI: 10.1128/JB.01332-07  0.36
2007 Neto BA, Lapis AA, Mancilha FS, Vasconcelos IB, Thum C, Basso LA, Santos DS, Dupont J. New sensitive fluorophores for selective DNA detection. Organic Letters. 9: 4001-4. PMID 17784767 DOI: 10.1021/ol701708y  0.36
2007 Dias MV, Ely F, Palma MS, de Azevedo WF, Basso LA, Santos DS. Chorismate synthase: an attractive target for drug development against orphan diseases. Current Drug Targets. 8: 437-44. PMID 17348836 DOI: 10.2174/138945007780058924  0.36
2007 Fonseca IO, Silva RG, Fernandes CL, de Souza ON, Basso LA, Santos DS. Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 457: 123-33. PMID 17178095 DOI: 10.1016/  0.36
2006 Silva RG, De Carvalho LPS, Blanchard JS, Santos DS, Basso LA. Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein (ACP) reductase: Kinetic and chemical mechanisms Biochemistry. 45: 13064-13073. PMID 17059223 DOI: 10.1021/bi0611210  0.36
2006 Borges JC, Pereira JH, Vasconcelos IB, dos Santos GC, Olivieri JR, Ramos CH, Palma MS, Basso LA, Santos DS, de Azevedo WF. Phosphate closes the solution structure of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 452: 156-64. PMID 16876105 DOI: 10.1016/  0.36
2006 Oliveira JS, de Sousa EH, de Souza ON, Moreira IS, Santos DS, Basso LA. Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex. Current Pharmaceutical Design. 12: 2409-24. PMID 16842188  0.36
2006 Dias MV, Canduri F, da Silveira NJ, Czekster CM, Basso LA, Palma MS, Santos DS, de Azevedo WF. Molecular models of tryptophan synthase from mycobacterium tuberculosis complexed with inhibitors. Cell Biochemistry and Biophysics. 44: 375-84. PMID 16679524 DOI: 10.1385/CBB:44:3:375  0.36
2006 Oliveira JS, Pereira JH, Canduri F, Rodrigues NC, de Souza ON, de Azevedo WF, Basso LA, Santos DS. Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis. Journal of Molecular Biology. 359: 646-66. PMID 16647717 DOI: 10.1016/j.jmb.2006.03.055  0.36
2006 Fonseca IO, Magalhães ML, Oliveira JS, Silva RG, Mendes MA, Palma MS, Santos DS, Basso LA. Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization. Protein Expression and Purification. 46: 429-37. PMID 16298142 DOI: 10.1016/j.pep.2005.10.004  0.36
2005 Silva RG, Pereira JH, Canduri F, de Azevedo WF, Basso LA, Santos DS. Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine. Archives of Biochemistry and Biophysics. 442: 49-58. PMID 16154528 DOI: 10.1016/  0.36
2005 Rizzi C, Frazzon J, Ely F, Weber PG, da Fonseca IO, Gallas M, Oliveira JS, Mendes MA, de Souza BM, Palma MS, Santos DS, Basso LA. DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme. Protein Expression and Purification. 40: 23-30. PMID 15721768 DOI: 10.1016/j.pep.2004.06.040  0.36
2005 Sousa EH, Pontes DL, Diógenes IC, Lopes LG, Oliveira JS, Basso LA, Santos DS, Moreira IS. Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs. Journal of Inorganic Biochemistry. 99: 368-75. PMID 15621268 DOI: 10.1016/j.jinorgbio.2004.10.004  0.36
2004 Nolasco DO, Canduri F, Pereira JH, Cortinóz JR, Palma MS, Oliveira JS, Basso LA, de Azevedo WF, Santos DS. Crystallographic structure of PNP from Mycobacterium tuberculosis at 1.9A resolution. Biochemical and Biophysical Research Communications. 324: 789-94. PMID 15474496 DOI: 10.1016/j.bbrc.2004.09.137  0.36
2004 Poletto SS, da Fonseca IO, de Carvalho LP, Basso LA, Santos DS. Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes. Protein Expression and Purification. 34: 118-25. PMID 14766307 DOI: 10.1016/j.pep.2003.10.009  0.36
2004 Oliveira JS, Sousa EH, Basso LA, Palaci M, Dietze R, Santos DS, Moreira IS. An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. Chemical Communications (Cambridge, England). 312-3. PMID 14740053 DOI: 10.1039/b313592f  0.36
2003 Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL. Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase. Biochemistry. 42: 6057-66. PMID 12755607 DOI: 10.1021/bi0343830  0.36
2003 Sauve AA, Cahill SM, Zech SG, Basso LA, Lewandowicz A, Santos DS, Grubmeyer C, Evans GB, Furneaux RH, Tyler PC, McDermott A, Girvin ME, Schramm VL. Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. Biochemistry. 42: 5694-705. PMID 12741826 DOI: 10.1021/bi034003a  0.36
2003 Oliveira JS, Mendes MA, Palma MS, Basso LA, Santos DS. One-step purification of 5-enolpyruvylshikimate-3-phosphate synthase enzyme from Mycobacterium tuberculosis Protein Expression and Purification. 28: 287-292. PMID 12699693 DOI: 10.1016/S1046-5928(02)00708-8  0.36
2003 Silva RG, Carvalho LP, Oliveira JS, Pinto CA, Mendes MA, Palma MS, Basso LA, Santos DS. Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase. Protein Expression and Purification. 27: 158-64. PMID 12509998 DOI: 10.1016/S1046-5928(02)00602-2  0.36
2002 Magalhães ML, Pereira CP, Basso LA, Santos DS. Cloning and expression of functional shikimate dehydrogenase (EC from Mycobacterium tuberculosis H37Rv. Protein Expression and Purification. 26: 59-64. PMID 12356471  0.36
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