| Year |
Citation |
Score |
| 2024 |
Joaquim AR, Lopes MS, Fortes IS, de Bem Gentz C, de Matos Czeczot A, Perelló MA, Roth CD, Vainstein MH, Basso LA, Bizarro CV, Machado P, de Andrade SF. Identification of antimycobacterial 8-hydroxyquinoline derivatives as in vitro enzymatic inhibitors of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase. Bioorganic Chemistry. 151: 107705. PMID 39137600 DOI: 10.1016/j.bioorg.2024.107705 |
0.368 |
|
| 2024 |
Borsoi AF, Silva Ramos A, Sperotto N, Abbadi BL, Souza Macchi Hopf F, da Silva Dadda A, Scheibler Rambo R, Neves Muniz M, Delgado Paz J, Silveira Grams E, Fries da Silva F, Pissinate K, Galina L, Calle González L, Silva Duarte L, ... ... Basso LA, et al. Exploring Scaffold Hopping for Novel 2-(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity. Acs Medicinal Chemistry Letters. 15: 493-500. PMID 38628799 DOI: 10.1021/acsmedchemlett.3c00570 |
0.318 |
|
| 2022 |
Freitas de Freitas T, Roth CD, Abbadi BL, Hopf FSM, Perelló MA, de Matos Czeczot A, de Souza EV, Borsoi AF, Machado P, Bizarro CV, Basso LA, Timmers LFSM. Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments. Journal of Computer-Aided Molecular Design. 1-12. PMID 36547753 DOI: 10.1007/s10822-022-00495-w |
0.393 |
|
| 2022 |
Paz JD, Denise de Moura Sperotto N, Ramos AS, Pissinate K, da Silva Rodrigues Junior V, Abbadi BL, Borsoi AF, Rambo RS, Corso Minotto AC, da Silva Dadda A, Galina L, Macchi Hopf FS, Muniz MN, Borges Martinelli LK, Roth CD, ... ... Basso LA, et al. Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation. European Journal of Medicinal Chemistry. 245: 114908. PMID 36435016 DOI: 10.1016/j.ejmech.2022.114908 |
0.399 |
|
| 2022 |
Galina L, Hopf FSM, Abbadi BL, Sperotto NDM, Czeczot AM, Duque-Villegas MA, Perello MA, Matter LB, de Souza EV, Parish T, Machado P, Basso LA, Bizarro CV. Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis. Microbiology Spectrum. e0072822. PMID 35862980 DOI: 10.1128/spectrum.00728-22 |
0.39 |
|
| 2021 |
Sidrônio MGS, Castelo Branco APOT, Abbadi BL, Macchi F, Silveira MD, Lock GA, Costa TD, de Araújo DM, Cibulski S, Bizarro CV, Machado P, Basso LA, Rodrigues-Junior VS. Effects of tafenoquine against active, dormant and resistant Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 128: 102089. PMID 34004588 DOI: 10.1016/j.tube.2021.102089 |
0.341 |
|
| 2021 |
Borsoi AF, Paz JD, Pissinate K, Rambo RS, Pestana VZ, Bizarro CV, Basso LA, Machado P. Ultrasound-Assisted Synthesis of 4-Alkoxy-2-methylquinolines: An Efficient Method toward Antitubercular Drug Candidates. Molecules (Basel, Switzerland). 26. PMID 33668389 DOI: 10.3390/molecules26051215 |
0.328 |
|
| 2020 |
Dalberto PF, de Souza EV, Abbadi BL, Neves CE, Rambo RS, Ramos AS, Macchi FS, Machado P, Bizarro CV, Basso LA. Handling the Hurdles on the Way to Anti-tuberculosis Drug Development. Frontiers in Chemistry. 8: 586294. PMID 33330374 DOI: 10.3389/fchem.2020.586294 |
0.345 |
|
| 2020 |
Nunes JES, Duque MA, de Freitas TF, Galina L, Timmers LFSM, Bizarro CV, Machado P, Basso LA, Ducati RG. Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs. Molecules (Basel, Switzerland). 25. PMID 32168746 DOI: 10.3390/Molecules25061259 |
0.458 |
|
| 2020 |
Borsoi AF, Paz JD, Abbadi BL, Macchi FS, Sperotto N, Pissinate K, Rambo RS, Ramos AS, Machado D, Viveiros M, Bizarro CV, Basso LA, Machado P. Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy)acetamide-based antituberculosis agents. European Journal of Medicinal Chemistry. 192: 112179. PMID 32113048 DOI: 10.1016/J.Ejmech.2020.112179 |
0.469 |
|
| 2020 |
Duarte LS, Barsé LQ, Dalberto PF, da Silva WTS, Rodrigues RC, Machado P, Basso LA, Bizarro CV, Ayub MAZ. Cloning and expression of the Bacillus amyloliquefaciens transglutaminase gene in E. coli using a bicistronic vector construction. Enzyme and Microbial Technology. 134: 109468. PMID 32044021 DOI: 10.1016/J.Enzmictec.2019.109468 |
0.302 |
|
| 2020 |
Nunes E, Villela AD, Basso LA, Teixeira E, Andrade A, Vasconcelos M, Neto LN, Gondim ACS, Diogenes ICN, Romo AI, Nascimento OR, Zampieri D, Paulo TF, Carvalho IMM, Lopes LGFdF, et al. Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case Inorganic Chemistry Frontiers. 7: 859-870. DOI: 10.1039/C9Qi01172B |
0.355 |
|
| 2019 |
Rodrigues-Junior VS, Villela AD, Abbadi BL, Sperotto NDM, Pissinate K, Picada JN, Bondan da Silva J, Bizarro CV, Machado P, Basso LA. Nonclinical evaluation of IQG-607, an anti-tuberculosis candidate with potential use in combination drug therapy. Regulatory Toxicology and Pharmacology : Rtp. 104553. PMID 31843592 DOI: 10.1016/J.Yrtph.2019.104553 |
0.416 |
|
| 2019 |
Machado P, Bizarro CV, Basso LA. Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis. Trends in Microbiology. PMID 31176512 DOI: 10.1016/J.Tim.2019.05.008 |
0.392 |
|
| 2019 |
Sperotto N, Deves Roth C, Rodrigues-Junior VS, Ev Neves C, Reisdorfer Paula F, da Silva Dadda A, Bergo P, Freitas de Freitas T, Souza Macchi F, Moura S, Duarte de Souza AP, Campos MM, Valim Bizarro C, Santos DS, Basso LA, et al. Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in vitro Toxicity, and Impact on Human Glioblastoma Cancer. Journal of Medicinal Chemistry. PMID 30615449 DOI: 10.1021/Acs.Jmedchem.8B01305 |
0.371 |
|
| 2019 |
Kappenberg YG, Ketzer A, Stefanello FS, Salbego PRS, Acunha TV, Abbadi BL, Bizarro CV, Basso LA, Machado P, Martins MAP, Zanatta N, Iglesias BA, Bonacorso HG. Synthesis and photophysical, thermal and antimycobacterial properties of novel 6-amino-2-alkyl(aryl/heteroaryl)-4-(trifluoromethyl) quinolines New Journal of Chemistry. 43: 12375-12384. DOI: 10.1039/C9Nj01681C |
0.346 |
|
| 2018 |
Muradás TC, Abbadi BL, Villela AD, Macchi FS, Bergo PF, de Freitas TF, Sperotto NDM, Timmers LFSM, Norberto de Souza O, Picada JN, Fachini J, da Silva JB, de Albuquerque NCP, Habenschus MD, Carrão DB, ... ... Basso LA, et al. Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis. Plos One. 13: e0202568. PMID 30114296 DOI: 10.1371/Journal.Pone.0202568 |
0.33 |
|
| 2018 |
Macchi FS, Pissinate K, Villela AD, Abbadi BL, Rodrigues-Junior V, Nabinger DD, Altenhofen S, Sperotto N, da Silva Dadda A, Subtil FT, de Freitas TF, Erhart Rauber AP, Borsoi AF, Bonan CD, Bizarro CV, ... Basso LA, et al. 1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity. European Journal of Medicinal Chemistry. 155: 153-164. PMID 29885576 DOI: 10.1016/J.Ejmech.2018.06.005 |
0.428 |
|
| 2018 |
Dalberto PF, Rodrigues-Junior V, Almeida Falcão VC, Pinto AFM, Abbadi BL, Bizarro CV, Basso LA, Villela AD, Santos DS. Assessing the role of deoD gene in Mycobacterium tuberculosis in vitro growth and macrophage infection. Microbial Pathogenesis. 119: 60-64. PMID 29608932 DOI: 10.1016/J.Micpath.2018.03.056 |
0.422 |
|
| 2018 |
Rodrigues-Junior VS, Pail PB, Villela AD, Falcão VCA, Dadda AS, Abbadi BL, Pesquero JB, Santos DS, Basso LA, Campos MM. Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice. Tuberculosis (Edinburgh, Scotland). 109: 1-7. PMID 29559112 DOI: 10.1016/J.Tube.2018.01.003 |
0.346 |
|
| 2018 |
Laborde J, Deraeve C, de Mesquita Vieira FG, Sournia-Saquet A, Rechignat L, Villela AD, Abbadi BL, Macchi FS, Pissinate K, Bizarro CV, Machado P, Basso LA, Pratviel G, de França Lopes LG, Sousa EHS, et al. Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy. Journal of Inorganic Biochemistry. 179: 71-81. PMID 29175704 DOI: 10.1016/J.Jinorgbio.2017.11.013 |
0.391 |
|
| 2017 |
Abbadi BL, Villela AD, Rodrigues-Junior VS, Subtil FT, Dalberto PF, Pinheiro APS, Santos DS, Machado P, Basso LA, Bizarro CV. Revisiting activation of and the mechanism of resistance to the compound IQG-607 in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 29158273 DOI: 10.1128/Aac.02222-17 |
0.371 |
|
| 2017 |
Dadda ADS, Rodrigues-Junior VS, Carreño F, Petersen GO, Pinto AFM, Dalberto PF, Sperotto NDM, Pissinate K, Bizarro CV, Machado P, Campos MM, Costa TD, Santos DS, Basso LA. Preclinical pharmacokinetic profiling of IQG-607, a potential oral metallodrug to treat tuberculosis. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29037995 DOI: 10.1016/J.Ejps.2017.10.020 |
0.329 |
|
| 2017 |
Subtil FT, Villela AD, Abbadi BL, Rodrigues-Junior VS, Bizarro CV, Timmers LFSM, de Souza ON, Pissinate K, Machado P, López-Gavín A, Tudó G, González-Martín J, Basso LA, Santos DS. Activity of 2-(quinolin-4-yloxy)acetamides in mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole genome sequencing. International Journal of Antimicrobial Agents. PMID 28843821 DOI: 10.1016/J.Ijantimicag.2017.08.023 |
0.433 |
|
| 2017 |
Rodrigues-Junior VS, Cintra L, Machado P, Dadda A, Basso LA, Mafra ACCN, Campos AH, Campos MM, Santos DS. Toxicological profile of IQG-607 after single and repeated oral administration in minipigs: An essential step towards phase I clinical trial. Regulatory Toxicology and Pharmacology : Rtp. PMID 28838610 DOI: 10.1016/J.Yrtph.2017.08.015 |
0.309 |
|
| 2017 |
Timmers LFSM, Neto AMS, Montalvão RW, Basso LA, Santos DS, Norberto de Souza O. EPSP synthase flexibility is determinant to its function: computational molecular dynamics and metadynamics studies. Journal of Molecular Modeling. 23: 197. PMID 28589464 DOI: 10.1007/S00894-017-3372-2 |
0.405 |
|
| 2017 |
Martinelli LKB, Rotta M, Villela AD, Rodrigues-Junior VS, Abbadi BL, Trindade RV, Petersen GO, Danesi GM, Nery LR, Pauli I, Campos MM, Bonan CD, de Souza ON, Basso LA, Santos DS. Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme. Scientific Reports. 7: 46696. PMID 28436453 DOI: 10.1038/Srep46696 |
0.509 |
|
| 2017 |
Falcão VC, Villela AD, Rodrigues-Junior VS, Pissinate K, Eichler P, Pinto AF, Basso LA, Santos DS, Bizarro CV. Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development. Biochemical and Biophysical Research Communications. PMID 28257847 DOI: 10.1016/J.Bbrc.2017.02.137 |
0.423 |
|
| 2017 |
Villela AD, Rodrigues VD, Pinto AF, Wink PL, Sánchez-Quitian ZA, Petersen GO, Campos MM, Basso LA, Santos DS. Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis. Memorias Do Instituto Oswaldo Cruz. 112: 203-208. PMID 28225907 DOI: 10.1590/0074-02760160462 |
0.369 |
|
| 2017 |
Villela AD, Pham H, Jones V, Grzegorzewicz AE, Rodrigues-Junior VD, Campos MM, Basso LA, Jackson M, Santos DS. Analysis of uracil phosphoribosyltransferase expression in Mycobacterium tuberculosis and evaluation of upp knockout strain in infected mice. Fems Microbiology Letters. PMID 28130366 DOI: 10.1093/Femsle/Fnx023 |
0.432 |
|
| 2017 |
Gazzi TP, Rotta M, Villela AD, Rodrigues-Junior V, Martinelli LKB, Sales FAM, Sousa EHSd, Campos MM, Basso LA, Santos DS, Machado P. Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II)-isonicotinoylhydrazones Journal of the Brazilian Chemical Society. 28: 2028-2037. DOI: 10.21577/0103-5053.20170033 |
0.415 |
|
| 2017 |
Galina L, Dalberto PF, Martinelli LKB, Roth CD, Pinto AFM, Villela AD, Bizarro CV, Machado P, Timmers LFSM, Souza ONd, Filho EMdC, Basso LA, Santos DS. Biochemical, thermodynamic and structural studies of recombinant homotetrameric adenylosuccinate lyase from Leishmania braziliensis Rsc Advances. 7: 54347-54360. DOI: 10.1039/C7Ra10526F |
0.408 |
|
| 2016 |
Giacobbo BC, Pissinate K, Rodrigues-Junior V, Villela AD, Grams ES, Abbadi BL, Subtil FT, Sperotto N, Trindade RV, Back DF, Campos MM, Basso LA, Machado P, Santos DS. New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 126: 491-501. PMID 27914363 DOI: 10.1016/J.Ejmech.2016.11.048 |
0.423 |
|
| 2016 |
Rodrigues-Junior VS, Villela AD, Gonçalves RS, Abbadi BL, Trindade RV, López-Gavín A, Tudó G, González-Martín J, Basso LA, de Souza MV, Campos MM, Santos DS. Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection. International Journal of Antimicrobial Agents. PMID 27364701 DOI: 10.1016/J.Ijantimicag.2016.04.029 |
0.422 |
|
| 2016 |
Pissinate K, Villela AD, Rodrigues-Junior V, Giacobbo BC, Grams ES, Abbadi BL, Trindade RV, Roesler Nery L, Bonan CD, Back DF, Campos MM, Basso LA, Santos DS, Machado P. 2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains. Acs Medicinal Chemistry Letters. 7: 235-9. PMID 26985307 DOI: 10.1021/Acsmedchemlett.5B00324 |
0.415 |
|
| 2016 |
Lunardi J, Martinelli LKB, Raupp AS, Nunes JES, Rostirolla DC, Timmers LFSM, Villela AD, Pissinate K, Limberger J, Souza ONd, Basso LA, Santos DS, Machado P. Mycobacterium tuberculosis histidinol dehydrogenase: biochemical characterization and inhibition studies Rsc Advances. 6: 28406-28418. DOI: 10.1039/C6Ra03020C |
0.347 |
|
| 2015 |
Villela AD, Eichler P, Pinto AFM, Rodrigues-Junior V, Yates Iii JR, Bizarro CV, Basso LA, Santos DS. Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth. Biochemistry and Biophysics Reports. 4: 277-282. PMID 29124214 DOI: 10.1016/J.Bbrep.2015.10.005 |
0.452 |
|
| 2015 |
Rotta M, Pissinate K, Villela AD, Back DF, Timmers LFSM, Bachega JFR, Souza ONd, Santos DS, Basso LA, Machado P. Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies. European Journal of Medicinal Chemistry. 90: 436-447. PMID 25461892 DOI: 10.1016/J.Ejmech.2014.11.034 |
0.445 |
|
| 2015 |
Pissinate K, Rostirolla DC, Pinheiro LM, Suryadevara P, Yogeeswari P, Sriram D, Basso LA, Machado P, Santos DS. Synthesis and Evaluation of Thiazolyl-1H-benzo[ d ]imidazole Inhibitors of Mycobacterium tuberculosis Inosine Monophosphate Dehydrogenase Journal of the Brazilian Chemical Society. 26: 1357-1366. DOI: 10.5935/0103-5053.20150104 |
0.434 |
|
| 2015 |
Sanchez-Quitian AZ, Rodrigues-Junior, Rehm JG, Eichler P, Trivella DBB, Bizarro CV, Basso LA, Santos DS. Crystal structure of E47Q mutant cytidine deaminase from Mycobacterium tuberculosis (MtCDA E47Q) Rsc Advances. DOI: 10.2210/Pdb4Wif/Pdb |
0.386 |
|
| 2015 |
Patta PC, Martinelli LKB, Rotta M, Abbadi BL, Santos DS, Basso LA. Mode of action of recombinant hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis Rsc Advances. 5: 74671-74683. DOI: 10.1039/C5Ra14918E |
0.515 |
|
| 2015 |
Sánchez-Quitian ZA, Rodrigues-Junior V, Rehm JG, Eichler P, Trivella DBB, Bizarro CV, Basso LA, Santos DS. Functional and structural evidence for the catalytic role played by glutamate-47 residue in the mode of action of Mycobacterium tuberculosis cytidine deaminase Rsc Advances. 5: 830-840. DOI: 10.1039/C4Ra13748E |
0.463 |
|
| 2014 |
Sousa EH, de Mesquita Vieira FG, Butler JS, Basso LA, Santiago DS, Diógenes IC, Lopes LG, Sadler PJ. [Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy. Journal of Inorganic Biochemistry. 140: 236-44. PMID 25189361 DOI: 10.1016/J.Jinorgbio.2014.08.002 |
0.36 |
|
| 2014 |
Assunção TMd, Batista EL, Deves C, Villela AD, Pagnussatti VE, Dias ACdO, Kritski A, Rodrigues-Junior V, Basso LA, Santos DS. Real time PCR quantification of viable Mycobacterium tuberculosis from sputum samples treated with propidium monoazide Tuberculosis. 94: 421-427. PMID 24863654 DOI: 10.1016/J.Tube.2014.04.008 |
0.416 |
|
| 2014 |
Deves C, Rostirolla DC, Martinelli LKB, Bizarro CV, Santos DS, Basso LA. The kinetic mechanism of Human Thymidine Phosphorylase-a molecular target for cancer drug development Molecular Biosystems. 10: 592-604. PMID 24407036 DOI: 10.1039/C3Mb70453J |
0.415 |
|
| 2014 |
Rodrigues-Junior VS, dos Santos Junior AA, Villela AD, Belardinelli JM, Morbidoni HR, Basso LA, Campos MM, Santos DS. IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages. International Journal of Antimicrobial Agents. 43: 82-5. PMID 24139881 DOI: 10.1016/J.Ijantimicag.2013.08.021 |
0.404 |
|
| 2014 |
Villela A, Rodrigues-Junior V, Basso LA, Santos D. Development of Mycobacterium tuberculosis attenuated strains as live vaccine candidates for tuberculosis. Bmc Proceedings. 8: 1-2. DOI: 10.1186/1753-6561-8-S4-O5 |
0.406 |
|
| 2014 |
Rostirolla DC, Assunção TMd, Bizarro CV, Basso LA, Santos DS. Biochemical characterization of Mycobacterium tuberculosis IMP dehydrogenase: kinetic mechanism, metal activation and evidence of a cooperative system Rsc Advances. 4: 26271-26287. DOI: 10.1039/C4Ra02142H |
0.474 |
|
| 2013 |
Renck D, Machado P, Souto AA, Rosado LA, Erig T, Campos MM, Farias CB, Roesler R, Timmers LF, de Souza ON, Santos DS, Basso LA. Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. Journal of Medicinal Chemistry. 56: 8892-902. PMID 24131420 DOI: 10.1021/Jm401389U |
0.35 |
|
| 2013 |
Lunardi J, Nunes JE, Bizarro CV, Basso LA, Santos DS, Machado P. Targeting the histidine pathway in Mycobacterium tuberculosis. Current Topics in Medicinal Chemistry. 13: 2866-84. PMID 24111909 DOI: 10.2174/15680266113136660203 |
0.481 |
|
| 2013 |
Wink PL, Quitian ZAS, Rosado LA, Rodrigues VdS, Petersen GO, Lorenzini DM, Lipinski-Paes T, Timmers LFSM, Souza ONd, Basso LA, Santos DS. Biochemical characterization of recombinant nucleoside hydrolase from Mycobacterium tuberculosis H37Rv. Archives of Biochemistry and Biophysics. 538: 80-94. PMID 23988349 DOI: 10.1016/J.Abb.2013.08.011 |
0.516 |
|
| 2013 |
Pauli I, dos Santos RN, Rostirolla DC, Martinelli LK, Ducati RG, Timmers LF, Basso LA, Santos DS, Guido RV, Andricopulo AD, Norberto de Souza O. Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach. Journal of Chemical Information and Modeling. 53: 2390-401. PMID 23889525 DOI: 10.1021/Ci400202T |
0.423 |
|
| 2013 |
Jaskulski L, Rosado LA, Rostirolla DC, Timmers LF, de Souza ON, Santos DS, Basso LA. Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase. Archives of Biochemistry and Biophysics. 536: 53-63. PMID 23756762 DOI: 10.1016/J.Abb.2013.05.012 |
0.383 |
|
| 2013 |
Jordão FM, Gabriel HB, Alves JM, Angeli CB, Bifano TD, Breda A, de Azevedo MF, Basso LA, Wunderlich G, Kimura EA, Katzin AM. Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum. Malaria Journal. 12: 184. PMID 23734739 DOI: 10.1186/1475-2875-12-184 |
0.38 |
|
| 2013 |
Rosado LA, Vasconcelos IB, Palma MS, Frappier V, Najmanovich RJ, Santos DS, Basso LA. The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses. Plos One. 8: e61918. PMID 23671579 DOI: 10.1371/Journal.Pone.0061918 |
0.464 |
|
| 2013 |
Villela AD, Ducati RG, Rosado LA, Bloch CJ, Prates MV, Gonçalves DC, Ramos CHI, Basso LA, Santos DS. Biochemical Characterization of Uracil Phosphoribosyltransferase from Mycobacterium tuberculosis Plos One. 8. PMID 23424660 DOI: 10.1371/Journal.Pone.0056445 |
0.484 |
|
| 2013 |
Roth G, Nunes JES, Rosado LA, Bizarro CV, Volpato G, Nunes CP, Renard G, Basso LA, Santos DS, Chies JM. Recombinant Erwinia carotovora l-asparaginase II production in Escherichia coli fed-batch cultures Brazilian Journal of Chemical Engineering. 30: 245-256. DOI: 10.1590/S0104-66322013000200003 |
0.306 |
|
| 2013 |
Machado P, Ritter E, Dos Santos AJB, Ev Neves C, Basso LA, Santos DS. Ultrasound-assisted improvement of drug solubility: A simple and useful method for the formation of salts from 4-hydroxy-6-methyl-3-nitropyridin-2(1H)- one Monatshefte Fur Chemie. 144: 1165-1170. DOI: 10.1007/S00706-013-0948-0 |
0.334 |
|
| 2012 |
Rosado LA, Caceres RA, de Azevedo WF, Basso LA, Santos DS. Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA). Bmc Research Notes. 5: 526. PMID 23006410 DOI: 10.1186/1756-0500-5-526 |
0.422 |
|
| 2012 |
Rodrigues-Junior VS, Dos Santos Junior A, Dos Santos AJ, Schneider CZ, Calixto JB, Sousa EH, de França Lopes LG, Souto AA, Basso LA, Santos DS, Campos MM. Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection. International Journal of Antimicrobial Agents. 40: 182-5. PMID 22748570 DOI: 10.1016/J.Ijantimicag.2012.04.019 |
0.409 |
|
| 2012 |
Breda A, Martinelli LK, Bizarro CV, Rosado LA, Borges CB, Santos DS, Basso LA. Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS? Plos One. 7: e39245. PMID 22745722 DOI: 10.1371/Journal.Pone.0039245 |
0.459 |
|
| 2012 |
Breda A, Machado P, Rosado LA, Souto AA, Santos DS, Basso LA. Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase. European Journal of Medicinal Chemistry. 54: 113-122. PMID 22608674 DOI: 10.1016/J.Ejmech.2012.04.031 |
0.535 |
|
| 2012 |
Franco TM, Rostirolla DC, Ducati RG, Lorenzini DM, Basso LA, Santos DS. Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain. Archives of Biochemistry and Biophysics. 517: 1-11. PMID 22119138 DOI: 10.1016/J.Abb.2011.11.013 |
0.453 |
|
| 2012 |
Moraes MCd, Donato AJ, Basso LA, Santos DS, Cardoso CL, Cass QB. Capillary bioreactors based on human purine nucleoside phosphorylase: a new approach for ligands identification and characterization. Journal of Chromatography A. 1232: 110-115. PMID 22099222 DOI: 10.1016/J.Chroma.2011.10.056 |
0.365 |
|
| 2012 |
Breda A, Rosado LA, Lorenzini DM, Basso LA, Santos DS. Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosisorotate phosphoribosyltransferase Molecular Biosystems. 8: 572-586. PMID 22075667 DOI: 10.1039/C1Mb05402C |
0.531 |
|
| 2012 |
Caceres RA, Timmers LF, Ducati RG, da Silva DO, Basso LA, de Azevedo WF, Santos DS. Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir. Biochimie. 94: 155-65. PMID 22033138 DOI: 10.1016/J.Biochi.2011.10.003 |
0.483 |
|
| 2012 |
Sousa EHS, Basso LA, Santos DS, Diógenes ICN, Longhinotti E, Lopes LGdF, Moreira ÍdS. Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design. Journal of Biological Inorganic Chemistry. 17: 275-283. PMID 21952749 DOI: 10.1007/S00775-011-0848-X |
0.427 |
|
| 2012 |
Timmers LFSME, Sánchez-Quitian ZA, Basso LA, Santos DS, Azevedo WFD. Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv. Journal of Molecular Modeling. 18: 467-479. PMID 21541749 DOI: 10.1007/S00894-011-1045-0 |
0.415 |
|
| 2011 |
Nunes JE, Ducati RG, Breda A, Rosado LA, de Souza BM, Palma MS, Santos DS, Basso LA. Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23). Archives of Biochemistry and Biophysics. 512: 143-53. PMID 21672513 DOI: 10.1016/J.Abb.2011.05.020 |
0.516 |
|
| 2011 |
de Medeiros PS, Ducati RG, Basso LA, Santos DS, da Silva LH. Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex. Enzyme Research. 2011: 642758. PMID 21603269 DOI: 10.4061/2011/642758 |
0.367 |
|
| 2011 |
Villela AD, Sanchez-Quitian ZA, Ducati RG, Santos DS, Basso LA. Pyrimidine salvage pathway in Mycobacterium tuberculosis. Current Medicinal Chemistry. 18: 1258-1275. PMID 21366536 DOI: 10.2174/092986711795029627 |
0.515 |
|
| 2011 |
Saidemberg DM, Passarelli AW, Rodrigues AV, Basso LA, Santos DS, Palma MS. Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development. Current Medicinal Chemistry. 18: 1299-310. PMID 21366533 DOI: 10.2174/092986711795029500 |
0.43 |
|
| 2011 |
Martinelli LK, Ducati RG, Rosado LA, Breda A, Selbach BP, Santos DS, Basso LA. Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme-ligand binary complex formation. Molecular Biosystems. 7: 1289-305. PMID 21298178 DOI: 10.1039/C0Mb00245C |
0.415 |
|
| 2011 |
Sánchez-Quitian ZA, Timmers LF, Caceres RA, Rehm JG, Thompson CE, Basso LA, de Azevedo WF, Santos DS. Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products. Archives of Biochemistry and Biophysics. 509: 108-15. PMID 21295009 DOI: 10.1016/J.Abb.2011.01.022 |
0.475 |
|
| 2011 |
Rostirolla DC, Breda A, Rosado LA, Palma MS, Basso LA, Santos DS. UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation. Archives of Biochemistry and Biophysics. 505: 202-12. PMID 21035424 DOI: 10.1016/J.Abb.2010.10.019 |
0.432 |
|
| 2011 |
de Mendonça JD, Adachi O, Rosado LA, Ducati RG, Santos DS, Basso LA. Kinetic mechanism determination and analysis of metal requirement of dehydroquinate synthase from Mycobacterium tuberculosis H37Rv: an essential step in the function-based rational design of anti-TB drugs. Molecular Biosystems. 7: 119-28. PMID 20978656 DOI: 10.1039/C0Mb00085J |
0.527 |
|
| 2010 |
Ducati RG, Basso LA, Santos DS, de Azevedo WF. Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry. 18: 4769-74. PMID 20570524 DOI: 10.1016/J.Bmc.2010.05.009 |
0.382 |
|
| 2010 |
Renck D, Ducati RG, Palma MS, Santos DS, Basso LA. The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy. Archives of Biochemistry and Biophysics. 497: 35-42. PMID 20226755 DOI: 10.1016/J.Abb.2010.03.004 |
0.419 |
|
| 2010 |
Sánchez-Quitian ZA, Schneider CZ, Ducati RG, de Azevedo WF, Bloch C, Basso LA, Santos DS. Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase. Journal of Structural Biology. 169: 413-23. PMID 20035876 DOI: 10.1016/J.Jsb.2009.12.019 |
0.427 |
|
| 2010 |
Caceres RA, Timmers LFSM, Pauli I, Gava LM, Basso LA, Santos DS, Azevedo WFd. Crystal structure and molecular dynamics studies of human purine nucleoside phosphorylase complexed with 7-deazaguanine. Journal of Structural Biology. 169: 379-388. PMID 19932753 DOI: 10.1016/J.Jsb.2009.11.010 |
0.351 |
|
| 2010 |
Wink PL, Bogdawa HM, Renard G, Chies JM, Basso LA, Santos DgS. Comparison between Two Erwinia carotovora L-Asparaginase II Constructions: cloning, Heterologous Expression, Purification, and Kinetic Characterization Journal of Microbial & Biochemical Technology. 2: 13-19. DOI: 10.4172/1948-5948.1000017 |
0.305 |
|
| 2010 |
Vasconcelos IB, Basso LA, Santos DS. Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberculosis enoyl reductase: implications to function-based antitubercular agent design Journal of the Brazilian Chemical Society. 21: 1503-1508. DOI: 10.1590/S0103-50532010000800014 |
0.511 |
|
| 2010 |
Basso LA, Schneider CZ, Santos AJABd, Santos, Campos MM, Souto AA, Santos DS. An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis Journal of the Brazilian Chemical Society. 21: 1384-1389. DOI: 10.1590/S0103-50532010000700026 |
0.457 |
|
| 2010 |
Neto BAD, Lapis AAM, Netz PA, Spencer J, Dias SLP, Tamborim SM, Basso LA, Santos DS, Dupont J, Maritime C. Synthesis and Enzymatic Evaluation of the Guanosine Analogue 2-Amino-6-mercapto- 7-methylpurine Ribonucleoside (MESG). Insights into the Phosphorolysis Reaction Mechanism based on the Blueprint Transition State: S N 1 or S N 2? Journal of the Brazilian Chemical Society. 21: 151-156. DOI: 10.1590/S0103-50532010000100022 |
0.339 |
|
| 2010 |
Ducati RG, Souto AA, Caceres RA, Azevedo WFd, Basso LA, Santos DS. Purine Nucleoside Phosphorylase as a Molecular Target to Develop Active Compounds Against Mycobacterium Tuberculosis International Review of Biophysical Chemistry. 1: 34-40. DOI: 10.15866/Irebic.V1I1.1490 |
0.488 |
|
| 2009 |
Rodrigues VS, Breda A, Santos DS, Basso LA. The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase. Bmc Research Notes. 2: 227. PMID 19917104 DOI: 10.1186/1756-0500-2-227 |
0.511 |
|
| 2009 |
Werlang IC, Schneider CZ, Mendonça JD, Palma MS, Basso LA, Santos DS. Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis. Microbiology (Reading, England). 155: 2652-63. PMID 19477901 DOI: 10.1099/Mic.0.030148-0 |
0.412 |
|
| 2009 |
Rodrigues-Junior VdS, Basso LA, Santos DS. Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: An essential step towards target-based drug design International Journal of Biological Macromolecules. 45: 200-205. PMID 19463851 DOI: 10.1016/J.Ijbiomac.2009.05.003 |
0.451 |
|
| 2009 |
Ducati RG, Santos DS, Basso LA. Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 486: 155-64. PMID 19416718 DOI: 10.1016/J.Abb.2009.04.011 |
0.472 |
|
| 2009 |
Czekster CM, Neto BA, Lapis AA, Dupont J, Santos DS, Basso LA. Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 486: 19-26. PMID 19364491 DOI: 10.1016/J.Abb.2009.04.001 |
0.753 |
|
| 2009 |
Biazus G, Schneider CZ, Palma MS, Basso LA, Santos DS. Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization. Protein Expression and Purification. 66: 185-90. PMID 19362594 DOI: 10.1016/J.Pep.2009.04.001 |
0.535 |
|
| 2009 |
Vivan AL, Caceres RA, Basso LA, Santos DS. Structural studies of PNP from Toxoplasma gondii. International Journal of Bioinformatics Research and Applications. 5: 154-62. PMID 19324601 DOI: 10.1504/Ijbra.2009.024095 |
0.332 |
|
| 2009 |
Timmers LFSM, Caceres RA, Dias R, Basso LA, Santos DS, Azevedo WFd. Molecular modeling, dynamics and docking studies of purine nucleoside phosphorylase from Streptococcus pyogenes. Biophysical Chemistry. 142: 7-16. PMID 19282092 DOI: 10.1016/J.Bpc.2009.02.006 |
0.337 |
|
| 2009 |
Thum C, Schneider CZ, Palma MS, Santos DS, Basso LA. The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP. Journal of Bacteriology. 191: 2884-7. PMID 19181797 DOI: 10.1128/Jb.01337-08 |
0.407 |
|
| 2009 |
Pauli I, Timmers LFSM, Caceres RA, Basso LA, Santos DS, Azevedo WFd. Molecular modeling and dynamics studies of purine nucleoside phosphorylase from Bacteroides fragilis. Journal of Molecular Modeling. 15: 913-922. PMID 19172318 DOI: 10.1007/S00894-008-0445-2 |
0.313 |
|
| 2008 |
Timmers LFSM, Caceres RA, Vivan AL, Gava LM, Dias R, Basso LA, Santos DS, Azevedo WFd. Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function. Archives of Biochemistry and Biophysics. 479: 28-38. PMID 18790691 DOI: 10.1016/J.Abb.2008.08.015 |
0.347 |
|
| 2008 |
Marques MR, Vaso A, Neto JR, Fossey MA, Oliveira JS, Basso LA, dos Santos DS, de Azevedo Junior WF, Palma MS. Dynamics of glyphosate-induced conformational changes of Mycobacterium tuberculosis 5-enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) determined by hydrogen-deuterium exchange and electrospray mass spectrometry. Biochemistry. 47: 7509-22. PMID 18558720 DOI: 10.1021/Bi800134Y |
0.43 |
|
| 2008 |
Ely F, Nunes JE, Schroeder EK, Frazzon J, Palma MS, Santos DS, Basso LA. The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase. Bmc Biochemistry. 9: 13. PMID 18445278 DOI: 10.1186/1471-2091-9-13 |
0.507 |
|
| 2008 |
Vivan AL, Caceres RA, Abrego JR, Borges JC, Ruggiero Neto J, Ramos CH, de Azevedo WF, Basso LA, Santos DS. Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis. Proteins. 72: 1352-62. PMID 18384085 DOI: 10.1002/Prot.22034 |
0.514 |
|
| 2008 |
Caceres RA, Timmers LFS, Dias R, Basso LA, Santos DS, Azevedo WFd. Molecular modeling and dynamics simulations of PNP from Streptococcus agalactiae Bioorganic & Medicinal Chemistry. 16: 4984-4993. PMID 18381241 DOI: 10.1016/J.Bmc.2008.03.044 |
0.365 |
|
| 2008 |
Caceres RA, Timmers LFSM, Vivan AL, Schneider CZ, Basso LA, Azevedo WFD, Santos DS. Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv Journal of Molecular Modeling. 14: 427-434. PMID 18343960 DOI: 10.1007/S00894-008-0291-2 |
0.346 |
|
| 2008 |
Arcuri HA, Borges JC, Fonseca IO, Pereira JH, Neto JR, Basso LA, Santos DS, de Azevedo WF. Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis. Proteins. 72: 720-30. PMID 18260104 DOI: 10.1002/Prot.21953 |
0.527 |
|
| 2008 |
Silva RG, Rosado LA, Santos DS, Basso LA. Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding. Archives of Biochemistry and Biophysics. 471: 1-10. PMID 18155153 DOI: 10.1016/J.Abb.2007.12.002 |
0.387 |
|
| 2008 |
Schneider CZ, Parish T, Basso LA, Santos DS. The two chorismate mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis: biochemical analysis and limited regulation of promoter activity by aromatic amino acids. Journal of Bacteriology. 190: 122-34. PMID 17965159 DOI: 10.1128/Jb.01332-07 |
0.477 |
|
| 2008 |
Santos DS, Vasconcelos IB, Meyer E, Sales FAM, Moreira IS, Basso LA. The Mode of Inhibition of Mycobacterium tuberculosis Wild-Type and Isoniazid-Resistant 2-Trans-Enoyl-ACP(CoA) Reductase Enzymes by An Inorganic Complex Anti-Infective Agents in Medicinal Chemistry. 7: 50-62. DOI: 10.2174/187152108783329799 |
0.424 |
|
| 2008 |
Breda A, Basso LA, Santos DS, Azevedo WFd. Virtual Screening of Drugs: Score Functions, Docking, and Drug Design Current Computer - Aided Drug Design. 4: 265-272. DOI: 10.2174/157340908786786047 |
0.329 |
|
| 2008 |
Czekster CM, Lapis AA, Souza GH, Eberlin MN, Basso LA, Santos DS, Dupont J, Neto BA. The catalytic mechanism of indole-3-glycerol phosphate synthase (IGPS) investigated by electrospray ionization (tandem) mass spectrometry Tetrahedron Letters. 49: 5914-5917. DOI: 10.1016/J.Tetlet.2008.07.149 |
0.734 |
|
| 2007 |
Júnior HP, Bica CG, Palaci M, Dietze R, Basso LA, Santos DS. Using polymerase chain reaction with primers based on the plcB-plcC intergenic region to detect Mycobacterium tuberculosis in clinical samples. Jornal Brasileiro De Pneumologia. 33: 437-442. PMID 17982536 DOI: 10.1590/S1806-37132007000400013 |
0.384 |
|
| 2007 |
Dias MV, Vasconcelos IB, Prado AM, Fadel V, Basso LA, de Azevedo WF, Santos DS. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. Journal of Structural Biology. 159: 369-80. PMID 17588773 DOI: 10.1016/J.Jsb.2007.04.009 |
0.405 |
|
| 2007 |
de Mendonça JD, Ely F, Palma MS, Frazzon J, Basso LA, Santos DS. Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification. Journal of Bacteriology. 189: 6246-52. PMID 17586643 DOI: 10.1128/Jb.00425-07 |
0.517 |
|
| 2007 |
Pereira JH, Vasconcelos IB, Oliveira JS, Caceres RA, de Azevedo WF, Basso LA, Santos DS. Shikimate kinase: a potential target for development of novel antitubercular agents. Current Drug Targets. 8: 459-68. PMID 17348838 DOI: 10.2174/138945007780059013 |
0.376 |
|
| 2007 |
Marques MR, Pereira JH, Oliveira JS, Basso LA, de Azevedo WF, Santos DS, Palma MS. The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials. Current Drug Targets. 8: 445-57. PMID 17348837 DOI: 10.2174/138945007780058951 |
0.406 |
|
| 2007 |
Dias MV, Ely F, Palma MS, de Azevedo WF, Basso LA, Santos DS. Chorismate synthase: an attractive target for drug development against orphan diseases. Current Drug Targets. 8: 437-44. PMID 17348836 DOI: 10.2174/138945007780058924 |
0.391 |
|
| 2007 |
Ducati RG, Basso LA, Santos DS. Mycobacterial Shikimate Pathway Enzymes as Targets for Drug Design Current Drug Targets. 8: 423-435. PMID 17348835 DOI: 10.2174/138945007780059004 |
0.48 |
|
| 2007 |
Silva RG, Nunes JES, Canduri F, Borges JC, Gava LM, Moreno FB, Basso LA, Santos DS. Purine nucleoside phosphorylase: a potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases. Current Drug Targets. 8: 413-422. PMID 17348834 DOI: 10.2174/138945007780058997 |
0.396 |
|
| 2007 |
Oliveira JS, Vasconcelos IB, Moreira IS, Santos DS, Basso LA. Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents. Current Drug Targets. 8: 399-411. PMID 17348833 DOI: 10.2174/138945007780058942 |
0.445 |
|
| 2007 |
Dias MV, FaÃm LM, Vasconcelos IB, de Oliveira JS, Basso LA, Santos DS, de Azevedo WF. Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 1-6. PMID 17183161 DOI: 10.1107/S1744309106046823 |
0.406 |
|
| 2007 |
Fonseca IO, Silva RG, Fernandes CL, de Souza ON, Basso LA, Santos DS. Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 457: 123-33. PMID 17178095 DOI: 10.1016/J.Abb.2006.11.015 |
0.41 |
|
| 2007 |
Fernandes CL, Breda A, Santos DS, Basso LA, Souza ONd. A structural model for chorismate synthase from Mycobacterium tuberculosis in complex with coenzyme and substrate Computers in Biology and Medicine. 37: 149-158. PMID 16584721 DOI: 10.1016/J.Compbiomed.2006.01.001 |
0.453 |
|
| 2006 |
Ruffino-Netto A, Basso LA, Santos DS. The resumption of consumption: a review on tuberculosis Memorias Do Instituto Oswaldo Cruz. 101: 697-714. PMID 17160276 DOI: 10.1590/S0074-02762006000700001 |
0.423 |
|
| 2006 |
Silva RG, De Carvalho LPS, Blanchard JS, Santos DS, Basso LA. Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein (ACP) reductase: Kinetic and chemical mechanisms Biochemistry. 45: 13064-13073. PMID 17059223 DOI: 10.1021/Bi0611210 |
0.593 |
|
| 2006 |
Borges JC, Pereira JH, Vasconcelos IB, dos Santos GC, Olivieri JR, Ramos CH, Palma MS, Basso LA, Santos DS, de Azevedo WF. Phosphate closes the solution structure of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 452: 156-64. PMID 16876105 DOI: 10.1016/J.Abb.2006.05.008 |
0.478 |
|
| 2006 |
Oliveira JS, de Sousa EH, de Souza ON, Moreira IS, Santos DS, Basso LA. Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex. Current Pharmaceutical Design. 12: 2409-24. PMID 16842188 DOI: 10.2174/138161206777698927 |
0.503 |
|
| 2006 |
De Azevedo WF, Canduri F, Basso LA, Palma MS, Santos DS. Determining the structural basis for specificity of ligands using crystallographic screening Cell Biochemistry and Biophysics. 44: 405-411. PMID 16679527 DOI: 10.1385/Cbb:44:3:405 |
0.365 |
|
| 2006 |
Dias MV, Canduri F, da Silveira NJ, Czekster CM, Basso LA, Palma MS, Santos DS, de Azevedo WF. Molecular models of tryptophan synthase from mycobacterium tuberculosis complexed with inhibitors. Cell Biochemistry and Biophysics. 44: 375-84. PMID 16679524 DOI: 10.1385/Cbb:44:3:375 |
0.751 |
|
| 2006 |
Oliveira JS, Pereira JH, Canduri F, Rodrigues NC, de Souza ON, de Azevedo WF, Basso LA, Santos DS. Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis. Journal of Molecular Biology. 359: 646-66. PMID 16647717 DOI: 10.1016/J.Jmb.2006.03.055 |
0.479 |
|
| 2006 |
Vivan AL, Dias MV, Schneider CZ, de Azevedo WF, Basso LA, Santos DS. Crystallization and preliminary X-ray diffraction analysis of prephenate dehydratase from Mycobacterium tuberculosis H37Rv. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 357-60. PMID 16582484 DOI: 10.1107/S1744309106006385 |
0.424 |
|
| 2006 |
Dias MV, Borges JC, Ely F, Pereira JH, Canduri F, Ramos CH, Frazzon J, Palma MS, Basso LA, Santos DS, de Azevedo WF. Structure of chorismate synthase from Mycobacterium tuberculosis. Journal of Structural Biology. 154: 130-43. PMID 16459102 DOI: 10.1016/j.jsb.2005.12.008 |
0.332 |
|
| 2006 |
Fonseca IO, Magalhães ML, Oliveira JS, Silva RG, Mendes MA, Palma MS, Santos DS, Basso LA. Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization. Protein Expression and Purification. 46: 429-37. PMID 16298142 DOI: 10.1016/J.Pep.2005.10.004 |
0.533 |
|
| 2005 |
Basso LA, da Silva LH, Fett-Neto AG, de Azevedo WF, Moreira Ide S, Palma MS, Calixto JB, Astolfi Filho S, dos Santos RR, Soares MB, Santos DS. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases--a review. Memã³Rias Do Instituto Oswaldo Cruz. 100: 475-506. PMID 16302058 DOI: 10.1590/S0074-02762005000600001 |
0.375 |
|
| 2005 |
Silva RG, Pereira JH, Canduri F, de Azevedo WF, Basso LA, Santos DS. Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine. Archives of Biochemistry and Biophysics. 442: 49-58. PMID 16154528 DOI: 10.1016/J.Abb.2005.07.021 |
0.424 |
|
| 2005 |
Canduri F, Silva RG, Dos Santos DM, Palma MS, Basso LA, Santos DS, De Azevedo WF. Structure of human PNP complexed with ligands Acta Crystallographica Section D: Biological Crystallography. 61: 856-862. PMID 15983407 DOI: 10.1107/S0907444905005421 |
0.322 |
|
| 2005 |
Schroeder EK, Basso LA, Santos DS, Souza ONd. Molecular Dynamics Simulation Studies of the Wild-Type, I21V, and I16T Mutants of Isoniazid-Resistant Mycobacterium tuberculosis Enoyl Reductase (InhA) in Complex with NADH: Toward the Understanding of NADH-InhA Different Affinities Biophysical Journal. 89: 876-884. PMID 15908576 DOI: 10.1529/Biophysj.104.053512 |
0.459 |
|
| 2005 |
Silveira NJFd, Uchôa HB, Pereira JH, Canduri F, Basso LA, Palma MS, Santos DS, Azevedo WFd. Molecular models of protein targets from Mycobacterium tuberculosis Journal of Molecular Modeling. 11: 160-166. PMID 15759144 DOI: 10.1007/S00894-005-0240-2 |
0.443 |
|
| 2005 |
Rizzi C, Frazzon J, Ely F, Weber PG, da Fonseca IO, Gallas M, Oliveira JS, Mendes MA, de Souza BM, Palma MS, Santos DS, Basso LA. DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme. Protein Expression and Purification. 40: 23-30. PMID 15721768 DOI: 10.1016/J.Pep.2004.06.040 |
0.507 |
|
| 2005 |
Canduri F, Fadel V, Basso LA, Palma MS, Santos DS, De Azevedo WF. New catalytic mechanism for human purine nucleoside phosphorylase Biochemical and Biophysical Research Communications. 327: 646-649. PMID 15649395 DOI: 10.1016/J.Bbrc.2004.12.052 |
0.326 |
|
| 2005 |
Sousa EH, Pontes DL, Diógenes IC, Lopes LG, Oliveira JS, Basso LA, Santos DS, Moreira IS. Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs. Journal of Inorganic Biochemistry. 99: 368-75. PMID 15621268 DOI: 10.1016/J.Jinorgbio.2004.10.004 |
0.382 |
|
| 2005 |
Canduri F, Fadel V, Dias MV, Basso LA, Palma MS, Santos DS, de Azevedo WF. Crystal structure of human PNP complexed with hypoxanthine and sulfate ion. Biochemical and Biophysical Research Communications. 326: 335-8. PMID 15582582 DOI: 10.1016/J.Bbrc.2004.11.038 |
0.328 |
|
| 2004 |
Pereira JH, de Oliveira JS, Canduri F, Dias MV, Palma MS, Basso LA, Santos DS, de Azevedo WF. Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid. Acta Crystallographica. Section D, Biological Crystallography. 60: 2310-9. PMID 15583379 DOI: 10.1107/S090744490402517X |
0.469 |
|
| 2004 |
Dias MV, Ely F, Canduri F, Pereira JH, Frazzon J, Basso LA, Palma MS, de Azevedo WF, Santos DS. Crystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis. Acta Crystallographica. Section D, Biological Crystallography. 60: 2003-5. PMID 15502309 DOI: 10.1107/S0907444904019869 |
0.363 |
|
| 2004 |
Nolasco DO, Canduri F, Pereira JH, Cortinóz JR, Palma MS, Oliveira JS, Basso LA, de Azevedo WF, Santos DS. Crystallographic structure of PNP from Mycobacterium tuberculosis at 1.9A resolution. Biochemical and Biophysical Research Communications. 324: 789-94. PMID 15474496 DOI: 10.1016/J.Bbrc.2004.09.137 |
0.43 |
|
| 2004 |
Silveira NJFd, Uchôa HB, Canduri F, Pereira JH, Camera JC, Basso LA, Palma MS, Santos DS, Azevedo WFd. Structural bioinformatics study of PNP from Schistosoma mansoni Biochemical and Biophysical Research Communications. 322: 100-104. PMID 15313179 DOI: 10.1016/J.Bbrc.2004.07.088 |
0.331 |
|
| 2004 |
Arcuri HA, Canduri F, Pereira JH, Silveira NJFd, Camera JC, Oliveira JSd, Basso LA, Palma MS, Santos DS, Azevedo WFd. Molecular models for shikimate pathway enzymes of Xylella fastidiosa. Biochemical and Biophysical Research Communications. 320: 979-991. PMID 15240145 DOI: 10.1016/J.Bbrc.2004.05.220 |
0.385 |
|
| 2004 |
Poletto SS, da Fonseca IO, de Carvalho LP, Basso LA, Santos DS. Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes. Protein Expression and Purification. 34: 118-25. PMID 14766307 DOI: 10.1016/J.Pep.2003.10.009 |
0.396 |
|
| 2004 |
Oliveira JS, Sousa EH, Basso LA, Palaci M, Dietze R, Santos DS, Moreira IS. An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. Chemical Communications (Cambridge, England). 312-3. PMID 14740053 DOI: 10.1039/B313592F |
0.428 |
|
| 2004 |
Canduri F, Santos DMd, Silva RG, Mendes MA, Basso LA, Palma MS, Azevedo WFd, Santos DS. Structures of human purine nucleoside phosphorylase complexed with inosine and ddI. Biochemical and Biophysical Research Communications. 313: 907-914. PMID 14706628 DOI: 10.1016/J.Bbrc.2003.11.179 |
0.381 |
|
| 2004 |
Azevedo WFd, Canduri F, Santos DMd, Pereira JH, Dias MVB, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochemical and Biophysical Research Communications. 312: 767-772. PMID 14680831 DOI: 10.1016/J.Bbrc.2003.10.190 |
0.379 |
|
| 2003 |
Pereira JH, Canduri F, Oliveira JSd, Silveira NJFd, Basso LA, Palma MS, Azevedo WFd, Santos DS. Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis. Biochemical and Biophysical Research Communications. 312: 608-614. PMID 14680808 DOI: 10.1016/J.Bbrc.2003.10.175 |
0.475 |
|
| 2003 |
Filgueira de Azevedo W, Canduri F, Marangoni dos Santos D, Pereira JH, Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Structural basis for inhibition of human PNP by immucillin-H. Biochemical and Biophysical Research Communications. 309: 917-22. PMID 13679061 DOI: 10.1016/J.Bbrc.2003.08.094 |
0.307 |
|
| 2003 |
de Azevedo WF, Canduri F, dos Santos DM, Silva RG, de Oliveira JS, de Carvalho LP, Basso LA, Mendes MA, Palma MS, Santos DS. Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution. Biochemical and Biophysical Research Communications. 308: 545-52. PMID 12914785 DOI: 10.1016/S0006-291X(03)01431-1 |
0.37 |
|
| 2003 |
Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL. Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase. Biochemistry. 42: 6057-66. PMID 12755607 DOI: 10.1021/Bi0343830 |
0.545 |
|
| 2003 |
Sauve AA, Cahill SM, Zech SG, Basso LA, Lewandowicz A, Santos DS, Grubmeyer C, Evans GB, Furneaux RH, Tyler PC, McDermott A, Girvin ME, Schramm VL. Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. Biochemistry. 42: 5694-705. PMID 12741826 DOI: 10.1021/Bi034003A |
0.532 |
|
| 2003 |
Oliveira JS, Mendes MA, Palma MS, Basso LA, Santos DS. One-step purification of 5-enolpyruvylshikimate-3-phosphate synthase enzyme from Mycobacterium tuberculosis Protein Expression and Purification. 28: 287-292. PMID 12699693 DOI: 10.1016/S1046-5928(02)00708-8 |
0.501 |
|
| 2003 |
Silva RG, Carvalho LP, Oliveira JS, Pinto CA, Mendes MA, Palma MS, Basso LA, Santos DS. Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase. Protein Expression and Purification. 27: 158-64. PMID 12509998 DOI: 10.1016/S1046-5928(02)00602-2 |
0.353 |
|
| 2003 |
Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL. Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase Biochemistry. 42: 6057-6066. DOI: 10.2210/Pdb1N3I/Pdb |
0.509 |
|
| 2003 |
Azevedo WFd, Santos GCd, Santos DMd, Olivieri JR, Canduri F, Silva RG, Basso LA, Renard G, Fonseca IOd, Mendes MA, Palma MS, Santos DS. Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase. Biochemical and Biophysical Research Communications. 309: 923-928. DOI: 10.1016/J.Bbrc.2003.08.093 |
0.316 |
|
| 2002 |
Magalhães ML, Pereira CP, Basso LA, Santos DS. Cloning and expression of functional shikimate dehydrogenase (EC 1.1.1.25) from Mycobacterium tuberculosis H37Rv. Protein Expression and Purification. 26: 59-64. PMID 12356471 DOI: 10.1016/S1046-5928(02)00509-0 |
0.494 |
|
| 2002 |
Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA. Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis. Current Pharmaceutical Biotechnology. 3: 197-225. PMID 12164478 DOI: 10.2174/1389201023378328 |
0.579 |
|
| 2002 |
De Azevedo WF, Canduri F, De Oliveira JS, Basso LA, Palma MS, Pereihenrra JH, Santos DS. Molecular model of shikimate kinase from Mycobacterium tuberculosis Biochemical and Biophysical Research Communications. 295: 142-148. PMID 12083781 DOI: 10.1016/S0006-291X(02)00632-0 |
0.464 |
|
| 2001 |
Oliveira JS, Pinto CA, Basso LA, Santos DS. Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis. Protein Expression and Purification. 22: 430-5. PMID 11483005 DOI: 10.1006/Prep.2001.1457 |
0.491 |
|
| 2001 |
Shi W, Basso LA, Santos DS, Tyler PC, Furneaux RH, Blanchard JS, Almo SC, Schramm VL. Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry. 40: 8204-15. PMID 11444966 DOI: 10.1021/Bi010585P |
0.724 |
|
| 2001 |
Basso LA, Santos DS, Shi W, Furneaux RH, Tyler PC, Schramm VL, Blanchard JS. Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts. Biochemistry. 40: 8196-203. PMID 11444965 DOI: 10.1021/Bi010584X |
0.692 |
|
| 1998 |
Basso LA, Blanchard JS. Resistance to antitubercular drugs. Advances in Experimental Medicine and Biology. 456: 115-44. PMID 10549366 DOI: 10.1007/978-1-4615-4897-3_7 |
0.605 |
|
| 1998 |
Basso LA, Zheng R, Musser JM, Jacobs WR, Blanchard JS. Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates. The Journal of Infectious Diseases. 178: 769-75. PMID 9728546 DOI: 10.1086/515362 |
0.607 |
|
| 1997 |
Basso LA, Engel PC, Walmsley AR. Kinetic studies on the binding of 1,N6-etheno-NAD+ to glutamate dehydrogenase from Clostridium symbiosum. Biochimica Et Biophysica Acta. 1340: 63-71. PMID 9217015 DOI: 10.1016/S0167-4838(97)00032-0 |
0.363 |
|
| 1996 |
Basso LA, Zheng R, Blanchard JS. Kinetics of inactivation of WT and C243S mutant of Mycobacterium tuberculosis enoyl reductase by activated isoniazid Journal of the American Chemical Society. 118: 11301-11302. DOI: 10.1021/Ja962035Y |
0.602 |
|
| 1994 |
Basso LA, Engel PC, Walmsley AR. Steady-state kinetics and transient studies of substrate and coenzyme analogue binding to clostridial glutamate dehydrogenase (GDH) during oxidative deamination Biochemical Society Transactions. 22: 319S. PMID 7821578 DOI: 10.1042/Bst022319S |
0.353 |
|
| 1994 |
Basso LA, Engel PC. Initial formation of a non-covalent enzyme-reagent complex during the inactivation of clostridial glutamate dehydrogenase by Ellman's reagent: determination of the enzyme's dissociation constant for the binary complex with NAD+ from protection studies. Biochimica Et Biophysica Acta. 1209: 222-6. PMID 7811694 DOI: 10.1016/0167-4838(94)90188-0 |
0.363 |
|
| 1993 |
Basso LA, Engel PC, Walmsley AR. The mechanism of substrate and coenzyme binding to clostridial glutamate dehydrogenase during oxidative deamination European Journal of Biochemistry. 213: 935-945. PMID 8099328 DOI: 10.1111/J.1432-1033.1993.Tb17838.X |
0.343 |
|
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