Thomas L. Poulos - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
Biochemistry

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Do HT, Li H, Chreifi G, Poulos TL, Silverman RB. Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. Journal of Medicinal Chemistry. PMID 30802056 DOI: 10.1021/acs.jmedchem.8b02032  0.4
2019 Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB. Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of Medicinal Chemistry. PMID 30633512 DOI: 10.1021/acs.jmedchem.8b02033  0.4
2018 Do HT, Wang HY, Li H, Chreifi G, Poulos TL, Silverman RB. Correction to Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of Medicinal Chemistry. PMID 30592215 DOI: 10.1021/acs.jmedchem.8b01866  0.4
2018 Li H, Evenson RJ, Chreifi G, Silverman RB, Poulos TL. The Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-Carboximidamides. Biochemistry. PMID 30335983 DOI: 10.1021/acs.biochem.8b00895  0.4
2017 Do HT, Wang HY, Li H, Chreifi G, Poulos TL, Silverman RB. Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of Medicinal Chemistry. PMID 29091437 DOI: 10.1021/acs.jmedchem.7b01356  0.4
2017 Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, ... ... Poulos TL, et al. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chemical Biology. 24: 1314. PMID 29053951 DOI: 10.1016/j.chembiol.2017.09.012  0.4
2017 Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, ... ... Poulos TL, et al. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chemical Biology. PMID 28919040 DOI: 10.1016/j.chembiol.2017.08.009  0.4
2017 Pensa AV, Cinelli MA, Li H, Chreifi G, Mukherjee P, Roman LJ, Martásek P, Poulos TL, Silverman RB. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. Journal of Medicinal Chemistry. PMID 28776992 DOI: 10.1021/acs.jmedchem.7b00835  0.4
2016 Poulos TL, Li H. Nitric oxide synthase and structure-based inhibitor design. Nitric Oxide : Biology and Chemistry. PMID 27890696 DOI: 10.1016/j.niox.2016.11.004  0.4
2016 Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL. Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors. Biochemistry. PMID 27607918 DOI: 10.1021/acs.biochem.6b00786  1
2016 Hollingsworth SA, Batabyal D, Nguyen BD, Poulos TL. Conformational selectivity in cytochrome P450 redox partner interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 27439869 DOI: 10.1073/pnas.1606474113  1
2016 Li H, Wang HY, Kang S, Silverman RB, Poulos TL. Electrostatic control of isoform selective inhibitor binding in nitric oxide synthase. Biochemistry. PMID 27250740 DOI: 10.1021/acs.biochem.6b00261  1
2016 Wang HY, Qin Y, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-based Scaffold with a Pyridine Linker. Journal of Medicinal Chemistry. PMID 27050842 DOI: 10.1021/acs.jmedchem.6b00273  1
2016 Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. Correction to Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Journal of Medicinal Chemistry. PMID 26807481 DOI: 10.1021/acs.jmedchem.6b00036  0.4
2016 Chreifi G, Baxter EL, Doukov T, Cohen AE, McPhillips SE, Song J, Meharenna YT, Soltis SM, Poulos TL. Crystal structure of the pristine peroxidase ferryl center and its relevance to proton-coupled electron transfer. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787871 DOI: 10.1073/pnas.1521664113  1
2015 Fields JB, Hollingsworth SA, Chreifi G, Heyden M, Arce AP, Magana-Garcia HI, Poulos TL, Tobias DJ. "Bind and Crawl" Association Mechanism of Leishmania major Peroxidase and Cytochrome c Revealed by Brownian and Molecular Dynamics Simulations. Biochemistry. PMID 26598276 DOI: 10.1021/acs.biochem.5b00569  1
2015 Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. Journal of Medicinal Chemistry. PMID 26469213 DOI: 10.1021/acs.jmedchem.5b01330  1
2015 Hollingsworth SA, Holden JK, Li H, Poulos TL. Elucidating Nitric Oxide Synthase Domain Interactions by Molecular Dynamics. Protein Science : a Publication of the Protein Society. PMID 26448477 DOI: 10.1002/pro.2824  0.4
2015 Kaur P, Chamberlin R, Poulos TL, Sevrioukova IF. Structure-based inhibitor design for evaluation of a CYP3A4 pharmacophore model. Journal of Medicinal Chemistry. PMID 26371436 DOI: 10.1021/acs.jmedchem.5b01146  1
2015 Kang S, Li H, Tang W, Martásek P, Roman LJ, Poulos TL, Silverman RB. 2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. Journal of Medicinal Chemistry. PMID 26120733 DOI: 10.1021/acs.jmedchem.5b00573  1
2015 Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chemistry & Biology. 22: 785-92. PMID 26091171 DOI: 10.1016/j.chembiol.2015.05.013  1
2015 Sevrioukova IF, Poulos TL. Anion-Dependent Stimulation of CYP3A4 Monooxygenase. Biochemistry. 54: 4083-96. PMID 26066995 DOI: 10.1021/acs.biochem.5b00510  1
2015 Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL. Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry. 54: 4075-82. PMID 26062720 DOI: 10.1021/acs.biochem.5b00431  1
2015 Astashkin AV, Chen L, Elmore BO, Kunwar D, Miao Y, Li H, Poulos TL, Roman LJ, Feng C. Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance. The Journal of Physical Chemistry. A. 119: 6641-9. PMID 26035438 DOI: 10.1021/acs.jpca.5b01804  1
2015 Sevrioukova IF, Poulos TL. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions. Advances in Experimental Medicine and Biology. 851: 83-105. PMID 26002732 DOI: 10.1007/978-3-319-16009-2_3  1
2015 Chreifi G, Hollingsworth SA, Li H, Tripathi S, Arce AP, Magaña-Garcia HI, Poulos TL. Enzymatic Mechanism of Leishmania major Peroxidase and the Critical Role of Specific Ionic Interactions. Biochemistry. 54: 3328-36. PMID 25941976 DOI: 10.1021/acs.biochem.5b00338  1
2015 Tang W, Li H, Doud EH, Chen Y, Choing S, Plaza C, Kelleher NL, Poulos TL, Silverman RB. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid. Journal of the American Chemical Society. 137: 5980-9. PMID 25874809 DOI: 10.1021/jacs.5b01202  1
2015 Tang W, Li H, Poulos TL, Silverman RB. Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines. Biochemistry. 54: 2530-8. PMID 25811913 DOI: 10.1021/acs.biochem.5b00135  1
2015 Kaluka D, Batabyal D, Chiang BY, Poulos TL, Yeh SR. Spectroscopic and mutagenesis studies of human PGRMC1. Biochemistry. 54: 1638-47. PMID 25675345 DOI: 10.1021/bi501177e  1
2015 Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. Structure-based design of bacterial nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 58: 994-1004. PMID 25522110 DOI: 10.1021/jm501723p  1
2015 Mukherjee P, Li H, Sevrioukova I, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 58: 1067-88. PMID 25489882 DOI: 10.1021/jm501719e  1
2015 Hollingsworth SA, Poulos TL. Molecular dynamics of the P450cam-Pdx complex reveals complex stability and novel interface contacts. Protein Science : a Publication of the Protein Society. 24: 49-57. PMID 25307478 DOI: 10.1002/pro.2583  1
2014 Li H, Jamal J, Plaza C, Pineda SH, Chreifi G, Jing Q, Cinelli MA, Silverman RB, Poulos TL. Structures of human constitutive nitric oxide synthases. Acta Crystallographica. Section D, Biological Crystallography. 70: 2667-74. PMID 25286850 DOI: 10.1107/S1399004714017064  1
2014 Holden JK, Lim N, Poulos TL. Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses. The Journal of Biological Chemistry. 289: 29437-45. PMID 25194416 DOI: 10.1074/jbc.M114.595165  1
2014 Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry Letters. 24: 4504-10. PMID 25149509 DOI: 10.1016/j.bmcl.2014.07.079  1
2014 Li H, Jamal J, Delker S, Plaza C, Ji H, Jing Q, Huang H, Kang S, Silverman RB, Poulos TL. The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Biochemistry. 53: 5272-9. PMID 25089924 DOI: 10.1021/bi500561h  1
2014 Astashkin AV, Chen L, Zhou X, Li H, Poulos TL, Liu KJ, Guillemette JG, Feng C. Pulsed electron paramagnetic resonance study of domain docking in neuronal nitric oxide synthase: the calmodulin and output state perspective. The Journal of Physical Chemistry. A. 118: 6864-72. PMID 25046446 DOI: 10.1021/jp503547w  1
2014 Chreifi G, Li H, McInnes CR, Gibson CL, Suckling CJ, Poulos TL. Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase. Biochemistry. 53: 4216-23. PMID 24819538 DOI: 10.1021/bi5003986  1
2014 Sevrioukova IF, Poulos TL. Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism. Current Topics in Medicinal Chemistry. 14: 1348-55. PMID 24805065 DOI: 10.2174/1568026614666140506120647  1
2014 Kang S, Tang W, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity Journal of Medicinal Chemistry. 57: 4382-4396. PMID 24758147 DOI: 10.1021/jm5004182  1
2014 Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. Acs Medicinal Chemistry Letters. 5: 56-60. PMID 24660051 DOI: 10.1021/ml400381s  1
2014 Madrona Y, Hollingsworth SA, Tripathi S, Fields JB, Rwigema JC, Tobias DJ, Poulos TL. Crystal structure of cindoxin, the P450cin redox partner. Biochemistry. 53: 1435-46. PMID 24533927 DOI: 10.1021/bi500010m  1
2014 Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition Journal of Medicinal Chemistry. 57: 1513-1530. PMID 24472039 DOI: 10.1021/jm401838x  1
2014 Huang H, Li H, Yang S, Chreifi G, Martásek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma Journal of Medicinal Chemistry. 57: 686-700. PMID 24447275 DOI: 10.1021/jm401252e  1
2014 Poulos TL. Heme enzyme structure and function. Chemical Reviews. 114: 3919-62. PMID 24400737 DOI: 10.1021/cr400415k  1
2013 Batabyal D, Poulos TL. Crystal structures and functional characterization of wild-type CYP101D1 and its active site mutants. Biochemistry. 52: 8898-906. PMID 24261604 DOI: 10.1021/bi401330c  1
2013 Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL. Structural and biological studies on bacterial nitric oxide synthase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 110: 18127-31. PMID 24145412 DOI: 10.1073/pnas.1314080110  1
2013 Jing Q, Li H, Chreifi G, Roman LJ, Martásek P, Poulos TL, Silverman RB. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5674-9. PMID 23993333 DOI: 10.1016/j.bmcl.2013.08.034  1
2013 Tripathi S, O'Neill MJ, Wilks A, Poulos TL. Crystal structure of the Pseudomonas aeruginosa cytoplasmic heme binding protein, Apo-PhuS. Journal of Inorganic Biochemistry. 128: 131-6. PMID 23973453 DOI: 10.1016/j.jinorgbio.2013.07.030  1
2013 Jing Q, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Bioorganic & Medicinal Chemistry. 21: 5323-31. PMID 23867386 DOI: 10.1016/j.bmc.2013.06.014  1
2013 Batabyal D, Li H, Poulos TL. Synergistic effects of mutations in cytochrome P450cam designed to mimic CYP101D1. Biochemistry. 52: 5396-402. PMID 23865948 DOI: 10.1021/bi400676d  1
2013 Madrona Y, Hollingsworth SA, Khan B, Poulos TL. P450cin active site water: implications for substrate binding and solvent accessibility. Biochemistry. 52: 5039-50. PMID 23829586 DOI: 10.1021/bi4006946  1
2013 Sevrioukova IF, Poulos TL. Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues. Biochemistry. 52: 4474-81. PMID 23746300 DOI: 10.1021/bi4005396  1
2013 Tripathi S, Li H, Poulos TL. Structural basis for effector control and redox partner recognition in cytochrome P450. Science (New York, N.Y.). 340: 1227-30. PMID 23744947 DOI: 10.1126/science.1235797  1
2013 Poulos TL, Madrona Y. Oxygen activation and redox partner binding in cytochromes P450. Biotechnology and Applied Biochemistry. 60: 128-33. PMID 23587000 DOI: 10.1002/bab.1056  1
2013 Labby KJ, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB. Methylated Nω-hydroxy-l-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction Biochemistry. 52: 3062-3073. PMID 23586781 DOI: 10.1021/bi301571v  1
2013 Sevrioukova IF, Poulos TL. Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir. Journal of Medicinal Chemistry. 56: 3733-41. PMID 23586711 DOI: 10.1021/jm400288z  1
2013 Li H, Jamal J, Chreifi G, Venkatesh V, Abou-Ziab H, Poulos TL. Dissecting the kinetics of the NADP(+)-FADH2 charge transfer complex and flavin semiquinones in neuronal nitric oxide synthase. Journal of Inorganic Biochemistry. 124: 1-10. PMID 23567464 DOI: 10.1016/j.jinorgbio.2013.03.008  1
2013 Li H, Li C, Zhou S, Poulos TL, Gershon PD. Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid. Acta Crystallographica. Section D, Biological Crystallography. 69: 617-24. PMID 23519670 DOI: 10.1107/S0907444913000346  1
2013 Huang H, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 56: 3024-3032. PMID 23451760 DOI: 10.1021/jm4000984  1
2013 Li H, Xue F, Kraus JM, Ji H, Labby KJ, Mataka J, Delker SL, Martásek P, Roman LJ, Poulos TL, Silverman RB. Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 21: 1333-1343. PMID 23352768 DOI: 10.1016/j.bmc.2012.12.019  1
2013 Yang Z, Misner B, Ji H, Poulos TL, Silverman RB, Meyskens FL, Yang S. Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma Antioxidants and Redox Signaling. 19: 433-447. PMID 23199242 DOI: 10.1089/ars.2012.4563  1
2013 Poulos TL, Li H. Structural basis for isoform-selective inhibition in nitric oxide synthase. Accounts of Chemical Research. 46: 390-8. PMID 23030042 DOI: 10.1021/ar300175n  1
2013 Sevrioukova IF, Poulos TL. Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems. Dalton Transactions (Cambridge, England : 2003). 42: 3116-26. PMID 23018626 DOI: 10.1039/c2dt31833d  1
2012 Jasion VS, Doukov T, Pineda SH, Li H, Poulos TL. Crystal structure of the Leishmania major peroxidase-cytochrome c complex. Proceedings of the National Academy of Sciences of the United States of America. 109: 18390-4. PMID 23100535 DOI: 10.1073/pnas.1213295109  1
2012 Martell JD, Deerinck TJ, Sancak Y, Poulos TL, Mootha VK, Sosinsky GE, Ellisman MH, Ting AY. Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy. Nature Biotechnology. 30: 1143-8. PMID 23086203 DOI: 10.1038/nbt.2375  1
2012 Jensen LM, Meharenna YT, Davidson VL, Poulos TL, Hedman B, Wilmot CM, Sarangi R. Geometric and electronic structures of the His-Fe(IV)=O and His-Fe(IV)-Tyr hemes of MauG. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 1241-55. PMID 23053529 DOI: 10.1007/s00775-012-0939-3  1
2012 Madrona Y, Tripathi S, Li H, Poulos TL. Crystal structures of substrate-free and nitrosyl cytochrome P450cin: implications for O(2) activation. Biochemistry. 51: 6623-31. PMID 22775403 DOI: 10.1021/bi300666u  1
2012 Huang H, Ji H, Li H, Jing Q, Labby KJ, Martásek P, Roman LJ, Poulos TL, Silverman RB. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. Journal of the American Chemical Society. 134: 11559-72. PMID 22731813 DOI: 10.1021/ja302269r  1
2012 Benabbas A, Karunakaran V, Youn H, Poulos TL, Champion PM. Effect of DNA binding on geminate CO recombination kinetics in CO-sensing transcription factor CooA. The Journal of Biological Chemistry. 287: 21729-40. PMID 22544803 DOI: 10.1074/jbc.M112.345090  1
2012 Sevrioukova IF, Poulos TL. Interaction of human cytochrome P4503A4 with ritonavir analogs. Archives of Biochemistry and Biophysics. 520: 108-16. PMID 22410611 DOI: 10.1016/j.abb.2012.02.018  1
2012 Jasion VS, Poulos TL. Leishmania major peroxidase is a cytochrome c peroxidase. Biochemistry. 51: 2453-60. PMID 22372542 DOI: 10.1021/bi300169x  1
2012 Labby KJ, Xue F, Kraus JM, Ji H, Mataka J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 20: 2435-2443. PMID 22370337 DOI: 10.1016/j.bmc.2012.01.037  1
2012 Sevrioukova IF, Poulos TL. Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligand. The Journal of Biological Chemistry. 287: 3510-7. PMID 22157006 DOI: 10.1074/jbc.M111.317081  1
2011 Xue F, Kraus JM, Labby KJ, Ji H, Mataka J, Xia G, Li H, Delker SL, Roman LJ, Martásek P, Poulos TL, Silverman RB. Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 6399-6403. PMID 21809851 DOI: 10.1021/jm200411j  1
2011 Jasion VS, Polanco JA, Meharenna YT, Li H, Poulos TL. Crystal structure of Leishmania major peroxidase and characterization of the compound i tryptophan radical. The Journal of Biological Chemistry. 286: 24608-15. PMID 21566139 DOI: 10.1074/jbc.M111.230524  1
2011 Doukov T, Li H, Sharma A, Martell JD, Soltis SM, Silverman RB, Poulos TL. Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors. Journal of the American Chemical Society. 133: 8326-34. PMID 21534614 DOI: 10.1021/ja201466v  1
2011 Xue F, Fang J, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 2039-2048. PMID 21410186 DOI: 10.1021/jm101071n  1
2011 Sevrioukova IF, Poulos TL. Structural biology of redox partner interactions in P450cam monooxygenase: a fresh look at an old system. Archives of Biochemistry and Biophysics. 507: 66-74. PMID 20816746 DOI: 10.1016/j.abb.2010.08.022  1
2010 Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase Biochemistry. 49: 10803-10810. PMID 21138269 DOI: 10.1021/bi1013479  1
2010 Ji H, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives Journal of Medicinal Chemistry. 53: 7804-7824. PMID 20958055 DOI: 10.1021/jm100947x  1
2010 Sevrioukova IF, Poulos TL. Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir. Proceedings of the National Academy of Sciences of the United States of America. 107: 18422-7. PMID 20937904 DOI: 10.1073/pnas.1010693107  1
2010 Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase Journal of the American Chemical Society. 132: 14229-14238. PMID 20843082 DOI: 10.1021/ja106175q  1
2010 Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Peripheral but crucial: A hydrophobic pocket (Tyr706, Leu 337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry Letters. 20: 6258-6261. PMID 20833542 DOI: 10.1016/j.bmcl.2010.08.096  1
2010 Xue F, Huang J, Ji H, Fang J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 18: 6526-6537. PMID 20673724 DOI: 10.1016/j.bmc.2010.06.074  1
2010 Meharenna YT, Poulos TL. Using molecular dynamics to probe the structural basis for enhanced stability in thermal stable cytochromes P450. Biochemistry. 49: 6680-6. PMID 20593793 DOI: 10.1021/bi100929x  1
2010 Sevrioukova IF, Poulos TL. Arginines 65 and 310 in putidaredoxin reductase are critical for interaction with putidaredoxin. Biochemistry. 49: 5160-6. PMID 20524621 DOI: 10.1021/bi100626f  1
2010 Sundaramoorthy M, Gold MH, Poulos TL. Ultrahigh (0.93A) resolution structure of manganese peroxidase from Phanerochaete chrysosporium: implications for the catalytic mechanism. Journal of Inorganic Biochemistry. 104: 683-90. PMID 20356630 DOI: 10.1016/j.jinorgbio.2010.02.011  1
2010 Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model Journal of the American Chemical Society. 132: 5437-5442. PMID 20337441 DOI: 10.1021/ja910228a  1
2010 Meharenna YT, Doukov T, Li H, Soltis SM, Poulos TL. Crystallographic and single-crystal spectral analysis of the peroxidase ferryl intermediate. Biochemistry. 49: 2984-6. PMID 20230048 DOI: 10.1021/bi100238r  1
2010 Poulos TL. Thirty years of heme peroxidase structural biology. Archives of Biochemistry and Biophysics. 500: 3-12. PMID 20206121 DOI: 10.1016/j.abb.2010.02.008  1
2010 Sevrioukova IF, Poulos TL, Churbanova IY. Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex. The Journal of Biological Chemistry. 285: 13616-20. PMID 20179327 DOI: 10.1074/jbc.M110.104968  1
2010 Martell JD, Li H, Doukov T, Martásek P, Roman LJ, Soltis M, Poulos TL, Silverman RB. Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. Journal of the American Chemical Society. 132: 798-806. PMID 20014790 DOI: 10.1021/ja908544f  1
2010 Churbanova IY, Poulos TL, Sevrioukova IF. Production and characterization of a functional putidaredoxin reductase-putidaredoxin covalent complex. Biochemistry. 49: 58-67. PMID 19954240 DOI: 10.1021/bi901872s  1
2009 Doukov T, Li H, Soltis M, Poulos TL. Single crystal structural and absorption spectral characterizations of nitric oxide synthase complexed with N(omega)-hydroxy-L-arginine and diatomic ligands. Biochemistry. 48: 10246-54. PMID 19791770 DOI: 10.1021/bi9009743  1
2009 Ioanoviciu A, Meharenna YT, Poulos TL, Ortiz de Montellano PR. DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy. Biochemistry. 48: 5839-48. PMID 19463006 DOI: 10.1021/bi802309y  1
2009 Li C, Li H, Zhou S, Sun E, Yoshizawa J, Poulos TL, Gershon PD. Polymerase translocation with respect to single-stranded nucleic acid: looping or wrapping of primer around a poly(A) polymerase. Structure (London, England : 1993). 17: 680-9. PMID 19446524 DOI: 10.1016/j.str.2009.03.012  1
2009 Igarashi J, Li H, Jamal J, Ji H, Fang J, Lawton GR, Silverman RB, Poulos TL. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors. Journal of Medicinal Chemistry. 52: 2060-6. PMID 19296678 DOI: 10.1021/jm900007a  1
2009 Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, Vásquez-Vivar J, Poulos TL, Silverman RB. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Annals of Neurology. 65: 209-17. PMID 19235180 DOI: 10.1002/ana.21555  1
2009 Ji H, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. Journal of Medicinal Chemistry. 52: 779-97. PMID 19125620 DOI: 10.1021/jm801220a  1
2008 Li H, Das A, Sibhatu H, Jamal J, Sligar SG, Poulos TL. Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential. The Journal of Biological Chemistry. 283: 34762-72. PMID 18852262 DOI: 10.1074/jbc.M806949200  1
2008 Meharenna YT, Oertel P, Bhaskar B, Poulos TL. Engineering ascorbate peroxidase activity into cytochrome c peroxidase. Biochemistry. 47: 10324-32. PMID 18771292 DOI: 10.1021/bi8007565  1
2008 Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH. Evolutionary history of a specialized p450 propane monooxygenase. Journal of Molecular Biology. 383: 1069-80. PMID 18619466 DOI: 10.1016/j.jmb.2008.06.060  1
2008 Ji H, Stanton BZ, Igarashi J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. Journal of the American Chemical Society. 130: 3900-14. PMID 18321097 DOI: 10.1021/ja0772041  1
2008 Meharenna YT, Slessor KE, Cavaignac SM, Poulos TL, De Voss JJ. The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cin. The Journal of Biological Chemistry. 283: 10804-12. PMID 18270198 DOI: 10.1074/jbc.M709722200  0.48
2008 Ho WW, Li H, Nishida CR, Ortiz De Montellano PR, Poulos TL. Crystal structure and properties of CYP231A2 from the thermoacidophilic archaeon Picrophilus torridus Biochemistry. 47: 2071-2079. PMID 18197710 DOI: 10.1021/bi702240k  1
2007 Ho WW, Li H, Eakanunkul S, Tong Y, Wilks A, Guo M, Poulos TL. Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins. The Journal of Biological Chemistry. 282: 35796-802. PMID 17925389 DOI: 10.1074/jbc.M706761200  1
2007 Poulos TL. Structural biology of p450-oxy complexes. Drug Metabolism Reviews. 39: 557-66. PMID 17786638 DOI: 10.1080/03602530701498240  1
2007 Ibrahim M, Kuchinskas M, Youn H, Kerby RL, Roberts GP, Poulos TL, Spiro TG. Mechanism of the CO-sensing heme protein CooA: New insights from the truncated heme domain and UVRR spectroscopy Journal of Inorganic Biochemistry. 101: 1776-1785. PMID 17720248 DOI: 10.1016/j.jinorgbio.2007.07.010  1
2007 Corbett MC, Latimer MJ, Poulos TL, Sevrioukova IF, Hodgson KO, Hedman B. Photoreduction of the active site of the metalloprotein putidaredoxin by synchrotron radiation. Acta Crystallographica. Section D, Biological Crystallography. 63: 951-60. PMID 17704563 DOI: 10.1107/S0907444907035160  1
2007 Kimmich N, Das A, Sevrioukova I, Meharenna Y, Sligar SG, Poulos TL. Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin. The Journal of Biological Chemistry. 282: 27006-11. PMID 17606612 DOI: 10.1074/jbc.M703790200  1
2007 Levin AM, Murase K, Jackson PJ, Flinspach ML, Poulos TL, Weiss GA. Double barrel shotgun scanning of the caveolin-1 scaffolding domain. Acs Chemical Biology. 2: 493-500. PMID 17602618 DOI: 10.1021/cb700055t  1
2007 Poulos TL. The Janus nature of heme. Natural Product Reports. 24: 504-10. PMID 17534526 DOI: 10.1039/b604195g  1
2007 Seo J, Igarashi J, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB. Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water. Journal of Medicinal Chemistry. 50: 2089-99. PMID 17425297 DOI: 10.1021/jm061305c  1
2007 Borjigin M, Li H, Lanz ND, Kerby RL, Roberts GP, Poulos TL. Structure-based hypothesis on the activation of the CO-sensing transcription factor CooA. Acta Crystallographica. Section D, Biological Crystallography. 63: 282-7. PMID 17327664 DOI: 10.1107/S0907444906051638  1
2007 Friedman J, Meharenna YT, Wilks A, Poulos TL. Diatomic ligand discrimination by the heme oxygenases from Neisseria meningitidis and Pseudomonas aeruginosa. The Journal of Biological Chemistry. 282: 1066-71. PMID 17095508 DOI: 10.1074/jbc.M609112200  1
2006 Poulos TL. Soluble guanylate cyclase. Current Opinion in Structural Biology. 16: 736-43. PMID 17015012 DOI: 10.1016/j.sbi.2006.09.006  1
2006 Kuznetsov VY, Poulos TL, Sevrioukova IF. Putidaredoxin-to-cytochrome P450cam electron transfer: differences between the two reductive steps required for catalysis. Biochemistry. 45: 11934-44. PMID 17002293 DOI: 10.1021/bi0611154  1
2006 Li H, Igarashi J, Jamal J, Yang W, Poulos TL. Structural studies of constitutive nitric oxide synthases with diatomic ligands bound. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 753-68. PMID 16804678 DOI: 10.1007/s00775-006-0123-8  1
2006 Kuchinskas M, Li H, Conrad M, Roberts G, Poulos TL. The role of the DNA-binding domains in CooA activation. Biochemistry. 45: 7148-53. PMID 16752905 DOI: 10.1021/bi052609o  1
2006 Swartz L, Kuchinskas M, Li H, Poulos TL, Lanzilotta WN. Redox-dependent structural changes in the Azotobacter vinelandii bacterioferritin: new insights into the ferroxidase and iron transport mechanism. Biochemistry. 45: 4421-8. PMID 16584178 DOI: 10.1021/bi060146w  1
2006 Mbadugha BN, Seo J, Ji H, Martásek P, Roman LJ, Shea TM, Li H, Poulos TL, Silverman RB. Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry. 14: 3681-90. PMID 16480878 DOI: 10.1016/j.bmc.2006.01.044  1
2005 Li H, Flinspach ML, Igarashi J, Jamal J, Yang W, Gómez-Vidal JA, Litzinger EA, Huang H, Erdal EP, Silverman RB, Poulos TL. Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases. Biochemistry. 44: 15222-9. PMID 16285725 DOI: 10.1021/bi0513610  1
2005 Barrows TP, Poulos TL. Role of electrostatics and salt bridges in stabilizing the compound I radical in ascorbate peroxidase. Biochemistry. 44: 14062-8. PMID 16245922 DOI: 10.1021/bi0507128  1
2005 Poulos TL. Structural biology of heme monooxygenases. Biochemical and Biophysical Research Communications. 338: 337-45. PMID 16185651 DOI: 10.1016/j.bbrc.2005.07.204  1
2005 Nagano S, Poulos TL. Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism. The Journal of Biological Chemistry. 280: 31659-63. PMID 15994329 DOI: 10.1074/jbc.M505261200  1
2005 Poulos TL. Intermediates in P450 catalysis. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 363: 793-806; discussion . PMID 15901536 DOI: 10.1098/rsta.2004.1537  1
2005 Bhaskar B, Poulos TL. The 1.13-A structure of iron-free cytochrome c peroxidase. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 10: 425-30. PMID 15900441 DOI: 10.1007/s00775-005-0654-4  1
2005 Sundaramoorthy M, Youngs HL, Gold MH, Poulos TL. High-resolution crystal structure of manganese peroxidase: substrate and inhibitor complexes. Biochemistry. 44: 6463-70. PMID 15850380 DOI: 10.1021/bi047318e  1
2005 Nagano S, Cupp-Vickery JR, Poulos TL. Crystal structures of the ferrous dioxygen complex of wild-type cytochrome P450eryF and its mutants, A245S and A245T: investigation of the proton transfer system in P450eryF. The Journal of Biological Chemistry. 280: 22102-7. PMID 15824115 DOI: 10.1074/jbc.M501732200  1
2004 Barrows TP, Bhaskar B, Poulos TL. Electrostatic control of the tryptophan radical in cytochrome c peroxidase. Biochemistry. 43: 8826-34. PMID 15236591 DOI: 10.1021/bi049531g  1
2004 Guo M, Bhaskar B, Li H, Barrows TP, Poulos TL. Crystal structure and characterization of a cytochrome c peroxidase-cytochrome c site-specific cross-link. Proceedings of the National Academy of Sciences of the United States of America. 101: 5940-5. PMID 15071191 DOI: 10.1073/pnas.0306708101  1
2004 Flinspach ML, Li H, Jamal J, Yang W, Huang H, Hah JM, Gómez-Vidal JA, Litzinger EA, Silverman RB, Poulos TL. Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nature Structural & Molecular Biology. 11: 54-9. PMID 14718923 DOI: 10.1038/nsmb704  1
2003 Yano JK, Poulos TL. New understandings of thermostable and peizostable enzymes. Current Opinion in Biotechnology. 14: 360-5. PMID 12943843 DOI: 10.1016/S0958-1669(03)00075-2  1
2003 Yano JK, Blasco F, Li H, Schmid RD, Henne A, Poulos TL. Preliminary characterization and crystal structure of a thermostable cytochrome P450 from Thermus thermophilus. The Journal of Biological Chemistry. 278: 608-16. PMID 12401810 DOI: 10.1074/jbc.M206568200  1
2002 Li H, Yano JK, Poulos TL. Molecular replacement in P450 crystal structure determinations. Methods in Enzymology. 357: 79-93. PMID 12424900 DOI: 10.1016/S0076-6879(02)57668-0  1
2002 Immoos CE, Bhaskar B, Cohen MS, Barrows TP, Farmer PJ, Poulos TL. Mesopone cytochrome c peroxidase: functional model of heme oxygenated oxidases. Journal of Inorganic Biochemistry. 91: 635-43. PMID 12237229 DOI: 10.1016/S0162-0134(02)00447-6  1
2000 Yano JK, Koo LS, Schuller DJ, Li H, Ortiz de Montellano PR, Poulos TL. Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus. The Journal of Biological Chemistry. 275: 31086-92. PMID 10859321 DOI: 10.1074/jbc.M004281200  1
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