Angela Wilks - Publications

Pharmaceutical Sciences University of Maryland School of Medicine, Baltimore, MD, United States 
Biochemistry, Molecular Biology, Cell Biology

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Heinzl GA, Huang W, Yu W, Giardina BJ, Zhou Y, MacKerell AD, Wilks A, Xue F. Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa. Journal of Medicinal Chemistry. PMID 27353344 DOI: 10.1021/acs.jmedchem.6b00757  0.96
2015 Smith AD, Modi AR, Sun S, Dawson JH, Wilks A. Spectroscopic Determination of Distinct Heme Ligands in Outer-Membrane Receptors PhuR and HasR of Pseudomonas aeruginosa. Biochemistry. 54: 2601-12. PMID 25849630 DOI: 10.1021/acs.biochem.5b00017  0.96
2015 Smith AD, Wilks A. Differential contributions of the outer membrane receptors PhuR and HasR to heme acquisition in Pseudomonas aeruginosa. The Journal of Biological Chemistry. 290: 7756-66. PMID 25616666 DOI: 10.1074/jbc.M114.633495  0.96
2015 Reinhart AA, Powell DA, Nguyen AT, O'Neill M, Djapgne L, Wilks A, Ernst RK, Oglesby-Sherrouse AG. The prrF-encoded small regulatory RNAs are required for iron homeostasis and virulence of Pseudomonas aeruginosa. Infection and Immunity. 83: 863-75. PMID 25510881 DOI: 10.1128/IAI.02707-14  0.96
2014 Wilks A, Ikeda-Saito M. Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin. Accounts of Chemical Research. 47: 2291-8. PMID 24873177 DOI: 10.1021/ar500028n  0.96
2014 Nguyen AT, O'Neill MJ, Watts AM, Robson CL, Lamont IL, Wilks A, Oglesby-Sherrouse AG. Adaptation of iron homeostasis pathways by a Pseudomonas aeruginosa pyoverdine mutant in the cystic fibrosis lung. Journal of Bacteriology. 196: 2265-76. PMID 24727222 DOI: 10.1128/JB.01491-14  0.96
2013 Tripathi S, O'Neill MJ, Wilks A, Poulos TL. Crystal structure of the Pseudomonas aeruginosa cytoplasmic heme binding protein, Apo-PhuS. Journal of Inorganic Biochemistry. 128: 131-6. PMID 23973453 DOI: 10.1016/j.jinorgbio.2013.07.030  0.96
2013 O'Neill MJ, Wilks A. The P. aeruginosa heme binding protein PhuS is a heme oxygenase titratable regulator of heme uptake. Acs Chemical Biology. 8: 1794-802. PMID 23947366 DOI: 10.1021/cb400165b  0.96
2013 Hom K, Heinzl GA, Eakanunkul S, Lopes PE, Xue F, MacKerell AD, Wilks A. Small molecule antivirulents targeting the iron-regulated heme oxygenase (HemO) of P. aeruginosa. Journal of Medicinal Chemistry. 56: 2097-109. PMID 23379514 DOI: 10.1021/jm301819k  0.96
2012 Barker KD, Barkovits K, Wilks A. Metabolic flux of extracellular heme uptake in Pseudomonas aeruginosa is driven by the iron-regulated heme oxygenase (HemO). The Journal of Biological Chemistry. 287: 18342-50. PMID 22493498 DOI: 10.1074/jbc.M112.359265  0.96
2012 O'Neill MJ, Bhakta MN, Fleming KG, Wilks A. Induced fit on heme binding to the Pseudomonas aeruginosa cytoplasmic protein (PhuS) drives interaction with heme oxygenase (HemO). Proceedings of the National Academy of Sciences of the United States of America. 109: 5639-44. PMID 22451925 DOI: 10.1073/pnas.1121549109  0.96
2012 Barker KD, Barkovits K, Wilks A. Metabolic flux of extracellular heme uptake in Pseudomonas aeruginosa is driven by the iron-regulated heme oxygenase (HemO) ( The Journal of Biological Chemistry (2012) 287, (18342-18350)) Journal of Biological Chemistry. 287: 27447. DOI: 10.1074/jbc.A112.359265  0.96
2010 Cunningham CW, Hom K, Acharya C, Wilks A, Mackerell AD, Coop A. Synthesis and Characterization of a Novel Diels - Alder Adduct of Codeine. Helvetica Chimica Acta. 93: 220-226. PMID 23378668 DOI: 10.1002/hlca.200900234  0.96
2008 Bhakta MN, Olabisi A, Wimalasena K, Wilks A. Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid. Journal of Inorganic Biochemistry. 102: 251-9. PMID 17923157 DOI: 10.1016/j.jinorgbio.2007.08.007  0.52
2007 Block DR, Lukat-Rodgers GS, Rodgers KR, Wilks A, Bhakta MN, Lansky IB. Identification of two heme-binding sites in the cytoplasmic heme-trafficking protein PhuS from Pseudomonas aeruginosa and their relevance to function. Biochemistry. 46: 14391-402. PMID 18020455 DOI: 10.1021/bi701509n  0.52
2007 Ho WW, Li H, Eakanunkul S, Tong Y, Wilks A, Guo M, Poulos TL. Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins. The Journal of Biological Chemistry. 282: 35796-802. PMID 17925389 DOI: 10.1074/jbc.M706761200  0.96
2007 Furci LM, Lopes P, Eakanunkul S, Zhong S, MacKerell AD, Wilks A. Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Journal of Medicinal Chemistry. 50: 3804-13. PMID 17629261 DOI: 10.1021/jm0700969  0.96
2007 Friedman J, Meharenna YT, Wilks A, Poulos TL. Diatomic ligand discrimination by the heme oxygenases from Neisseria meningitidis and Pseudomonas aeruginosa. The Journal of Biological Chemistry. 282: 1066-71. PMID 17095508 DOI: 10.1074/jbc.M609112200  0.96
2006 Alontaga AY, Bunce RA, Wilks A, Rivera M. 13C NMR spectroscopy of core heme carbons as a simple tool to elucidate the coordination state of ferric high-spin heme proteins. Inorganic Chemistry. 45: 8876-81. PMID 17054345 DOI: 10.1021/ic0607484  0.96
2006 Bhakta MN, Wilks A. The mechanism of heme transfer from the cytoplasmic heme binding protein PhuS to the delta-regioselective heme oxygenase of Pseudomonas aeruginosa. Biochemistry. 45: 11642-9. PMID 16981723 DOI: 10.1021/bi060980l  0.52
2006 Lansky IB, Lukat-Rodgers GS, Block D, Rodgers KR, Ratliff M, Wilks A. The cytoplasmic heme-binding protein (PhuS) from the heme uptake system of Pseudomonas aeruginosa is an intracellular heme-trafficking protein to the delta-regioselective heme oxygenase. The Journal of Biological Chemistry. 281: 13652-62. PMID 16533806 DOI: 10.1074/jbc.M600824200  0.96
2005 Damaso CO, Bunce RA, Barybin MV, Wilks A, Rivera M. The ferrous verdoheme-heme oxygenase complex is six-coordinate and low-spin. Journal of the American Chemical Society. 127: 17582-3. PMID 16351069 DOI: 10.1021/ja055099u  0.96
2005 Deshmukh R, Zeng Y, Furci LM, Huang HW, Morgan BN, Sander S, Alontaga AY, Bunce RA, Moënne-Loccoz P, Rivera M, Wilks A. Heme oxidation in a chimeric protein of the alpha-selective Neisseriae meningitidis heme oxygenase with the distal helix of the delta-selective Pseudomonas aeruginosa. Biochemistry. 44: 13713-23. PMID 16229461 DOI: 10.1021/bi050810t  0.96
2005 Eakanunkul S, Lukat-Rodgers GS, Sumithran S, Ghosh A, Rodgers KR, Dawson JH, Wilks A. Characterization of the periplasmic heme-binding protein shut from the heme uptake system of Shigella dysenteriae. Biochemistry. 44: 13179-91. PMID 16185086 DOI: 10.1021/bi050422r  0.96
2005 Zeng Y, Caignan GA, Bunce RA, Rodríguez JC, Wilks A, Rivera M. Azide-inhibited bacterial heme oxygenases exhibit an S = 3/2 (dxz,dyz)3(dxy)1(dz2)1 spin state: mechanistic implications for heme oxidation. Journal of the American Chemical Society. 127: 9794-807. PMID 15998084 DOI: 10.1021/ja0425987  0.96
2004 Wyckoff EE, Schmitt M, Wilks A, Payne SM. HutZ is required for efficient heme utilization in Vibrio cholerae. Journal of Bacteriology. 186: 4142-51. PMID 15205415 DOI: 10.1128/JB.186.13.4142-4151.2004  0.96
2004 Friedman J, Lad L, Li H, Wilks A, Poulos TL. Structural Basis for Novel δ-Regioselective Heme Oxygenation in the Opportunistic Pathogen Pseudomonas aeruginosa Biochemistry. 43: 5239-5245. PMID 15122889 DOI: 10.1021/bi049687g  0.96
2004 Zeng Y, Deshmukh R, Caignan GA, Bunce RA, Rivera M, Wilks A. Mixed regioselectivity in the Arg-177 mutants of Corynebacterium diphtheriae heme oxygenase as a consequence of in-plane heme disorder. Biochemistry. 43: 5222-38. PMID 15122888 DOI: 10.1021/bi035970o  0.96
2003 Caignan GA, Deshmukh R, Zeng Y, Wilks A, Bunce RA, Rivera M. The hydroxide complex of Pseudomonas aeruginosa heme oxygenase as a model of the low-spin iron(III) hydroperoxide intermediate in heme catabolism: 13C NMR spectroscopic studies suggest the active participation of the heme in macrocycle hydroxylation. Journal of the American Chemical Society. 125: 11842-52. PMID 14505406 DOI: 10.1021/ja036147i  0.96
2003 Friedman J, Lad L, Deshmukh R, Li H, Wilks A, Poulos TL. Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis: Implications for O2 activation Journal of Biological Chemistry. 278: 34654-34659. PMID 12819228 DOI: 10.1074/jbc.M302985200  0.96
2002 Caignan GA, Deshmukh R, Wilks A, Zeng Y, Huang HW, Moënne-Loccoz P, Bunce RA, Eastman MA, Rivera M. Oxidation of heme to beta- and delta-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme. Journal of the American Chemical Society. 124: 14879-92. PMID 12475329 DOI: 10.1021/ja0274960  0.96
2002 Li Y, Syvitski RT, Auclair K, Wilks A, Ortiz De Montellano PR, La Mar GN. Solution NMR characterization of an unusual distal H-bond network in the active site of the cyanide-inhibited, human heme oxygenase complex of the symmetric substrate, 2,4-dimethyldeuterohemin. The Journal of Biological Chemistry. 277: 33018-31. PMID 12070167 DOI: 10.1074/jbc.M204216200  0.96
2001 Ratliff M, Zhu W, Deshmukh R, Wilks A, Stojiljkovic I. Homologues of neisserial heme oxygenase in gram-negative bacteria: Degradation of heme by the product of the pigA gene of Pseudomonas aeruginosa Journal of Bacteriology. 183: 6394-6403. PMID 11591684 DOI: 10.1128/JB.183.21.6394-6403.2001  0.96
2001 Schuller DJ, Zhu W, Stojiljkovic I, Wilks A, Poulos TL. Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1 Biochemistry. 40: 11552-11558. PMID 11560504 DOI: 10.1021/bi0110239  0.96
2000 Zhu W, Wilks A, Stojiljkovic I. Degradation of heme in gram-negative bacteria: The product of the hemO gene of neisseriae is a heme oxygenase Journal of Bacteriology. 182: 6783-6790. PMID 11073924 DOI: 10.1128/JB.182.23.6783-6790.2000  0.96
1999 Schuller DJ, Wilks A, Ortiz De Montellano PR, Poulos TL. Crystal structure of human heme oxygenase-1 Nature Structural Biology. 6: 860-867. PMID 10467099 DOI: 10.1038/12319  0.96
1999 Pond AE, Roach MP, Sono M, Rux AH, Franzen S, Hu R, Thomas MR, Wilks A, Dou Y, Ikeda-Saito M, Ortiz de Montellano PR, Woodruff WH, Boxer SG, Dawson JH. Assignment of the heme axial ligand(s) for the ferric myoglobin (H93G) and heme oxygenase (H25A) cavity mutants as oxygen donors using magnetic circular dichroism. Biochemistry. 38: 7601-8. PMID 10360958 DOI: 10.1021/bi9825448  0.96
1999 Liu Y, Moënne-Loccoz P, Hildebrand DP, Wilks A, Loehr TM, Mauk AG, Ortiz De Montellano PR. Replacement of the proximal histidine iron ligand by a cysteine or tyrosine converts heme oxygenase to an oxidase Biochemistry. 38: 3733-3743. PMID 10090762 DOI: 10.1021/bi982707s  0.96
1998 Schuller DJ, Wilks A, De Montellano PO, Poulos TL. Crystallization of recombinant human heme oxygenase-1 Protein Science. 7: 1836-1838. PMID 10082382 DOI: 10.1002/pro.5560070820  0.96
1998 Wilks A, Medzihradszky KF, Ortiz de Montellano PR. Heme oxygenase active-site residues identified by heme-protein cross- linking during reduction of CBrCl3 Biochemistry. 37: 2889-2896. PMID 9485440 DOI: 10.1021/bi972720x  0.96
1998 Gorst CM, Wilks A, Yeh DC, Ortiz De Montellano PR, La Mar GN. Solution 1H NMR investigation of the molecular and electronic structure of the active site of substrate-bound human heme oxygenase: The nature of the distal hydrogen bond donor to bound ligands Journal of the American Chemical Society. 120: 8875-8884. DOI: 10.1021/ja9815475  0.96
1996 Hawkins BK, Wilks A, Powers LS, Ortiz de Montellano PR, Dawson JH. Ligation of the iron in the heme-heme oxygenase complex: X-ray absorption, electronic absorption and magnetic circular dichroism studies. Biochimica Et Biophysica Acta. 1295: 165-73. PMID 8695642 DOI: 10.1016/0167-4838(96)00031-3  0.96
1994 Hernández G, Wilks A, Paolesse R, Smith KM, Ortiz de Montellano PR, La Mar GN. Proton NMR investigation of substrate-bound heme oxygenase: evidence for electronic and steric contributions to stereoselective heme cleavage. Biochemistry. 33: 6631-41. PMID 8204600  0.96
1992 Allentoff AJ, Bolton JL, Wilks A, Thompson JA, Ortiz De Montellano PR. Heterolytic versus homolytic peroxide bond cleavage by sperm whale myoglobin and myoglobin mutants Journal of the American Chemical Society. 114: 9744-9749.  0.96
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