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Douglas A. Mitchell - Publications

Affiliations: 
Chemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
antibiotic resistance
Website:
http://www.chemistry.illinois.edu/faculty/Douglas_Mitchell.html

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Tietz JI, Schwalen CJ, Patel PS, Maxson T, Blair PM, Tai HC, Zakai UI, Mitchell DA. A new genome-mining tool redefines the lasso peptide biosynthetic landscape. Nature Chemical Biology. PMID 28244986 DOI: 10.1038/nchembio.2319  0.64
2016 Deane CD, Burkhart BJ, Blair PM, Tietz JI, Lin A, Mitchell DA. In vitro biosynthesis and substrate tolerance of the plantazolicin family of natural products. Acs Chemical Biology. PMID 27248686 DOI: 10.1021/acschembio.6b00369  0.64
2016 Molloy EM, Tietz JI, Blair PM, Mitchell DA. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorganic & Medicinal Chemistry. PMID 27234886 DOI: 10.1016/j.bmc.2016.05.021  1
2016 Molohon KJ, Blair PM, Park S, Doroghazi JR, Maxson T, Hershfield JR, Flatt KM, Schroeder NE, Ha T, Mitchell DA. Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane. Acs Infectious Diseases. 2: 207-220. PMID 27152321 DOI: 10.1021/acsinfecdis.5b00115  1
2015 Maxson T, Bertke JA, Gray DL, Mitchell DA. Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1401-1407. PMID 26594520 DOI: 10.1107/S2056989015020046  1
2015 Cox CL, Doroghazi JR, Mitchell DA. The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles. Bmc Genomics. 16: 778. PMID 26462797 DOI: 10.1186/s12864-015-2008-0  1
2015 Tietz JI, Mitchell DA. Using Genomics for Natural Product Structure Elucidation. Current Topics in Medicinal Chemistry. PMID 26456468  1
2015 Burkhart BJ, Hudson GA, Dunbar KL, Mitchell DA. A prevalent peptide-binding domain guides ribosomal natural product biosynthesis. Nature Chemical Biology. PMID 26167873 DOI: 10.1038/nchembio.1856  1
2015 Dunbar KL, Tietz JI, Cox CL, Burkhart BJ, Mitchell DA. Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products. Journal of the American Chemical Society. 137: 7672-7. PMID 26024319 DOI: 10.1021/jacs.5b04682  1
2015 Maxson T, Deane CD, Molloy EM, Cox CL, Markley AL, Lee SW, Mitchell DA. HIV protease inhibitors block streptolysin S production. Acs Chemical Biology. 10: 1217-26. PMID 25668590 DOI: 10.1021/cb500843r  1
2015 Hao Y, Blair PM, Sharma A, Mitchell DA, Nair SK. Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin. Acs Chemical Biology. 10: 1209-16. PMID 25635336 DOI: 10.1021/cb501042a  1
2015 Metelev M, Tietz JI, Melby JO, Blair PM, Zhu L, Livnat I, Severinov K, Mitchell DA. Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete. Chemistry & Biology. 22: 241-50. PMID 25601074 DOI: 10.1016/j.chembiol.2014.11.017  1
2015 Molloy EM, Casjens SR, Cox CL, Maxson T, Ethridge NA, Margos G, Fingerle V, Mitchell DA. Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family Bmc Microbiology. 15. DOI: 10.1186/s12866-015-0464-y  1
2014 Dunbar KL, Chekan JR, Cox CL, Burkhart BJ, Nair SK, Mitchell DA. Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis. Nature Chemical Biology. 10: 823-9. PMID 25129028 DOI: 10.1038/nchembio.1608  1
2014 Zhang Q, Ortega M, Shi Y, Wang H, Melby JO, Tang W, Mitchell DA, van der Donk WA. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS. Proceedings of the National Academy of Sciences of the United States of America. 111: 12031-6. PMID 25092299 DOI: 10.1073/pnas.1406418111  1
2014 Cox CL, Tietz JI, Sokolowski K, Melby JO, Doroghazi JR, Mitchell DA. Nucleophilic 1,4-additions for natural product discovery. Acs Chemical Biology. 9: 2014-22. PMID 24937678 DOI: 10.1021/cb500324n  1
2014 Hamel LD, Deschenes RJ, Mitchell DA. A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening. Analytical Biochemistry. 460: 1-8. PMID 24878334 DOI: 10.1016/j.ab.2014.05.013  0.92
2014 Mitchell DA, Hamel LD, Reddy KD, Farh L, Rettew LM, Sanchez PR, Deschenes RJ. Mutations in the X-linked intellectual disability gene, zDHHC9, alter autopalmitoylation activity by distinct mechanisms. The Journal of Biological Chemistry. 289: 18582-92. PMID 24811172 DOI: 10.1074/jbc.M114.567420  0.92
2014 Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, ... ... Mitchell DA, et al. Multitarget drug discovery for tuberculosis and other infectious diseases. Journal of Medicinal Chemistry. 57: 3126-39. PMID 24568559 DOI: 10.1021/jm500131s  1
2014 Melby JO, Li X, Mitchell DA. Orchestration of enzymatic processing by thiazole/oxazole-modified microcin dehydrogenases. Biochemistry. 53: 413-22. PMID 24364559 DOI: 10.1021/bi401529y  1
2014 Deane CD, Mitchell DA. Lessons learned from the transformation of natural product discovery to a genome-driven endeavor. Journal of Industrial Microbiology & Biotechnology. 41: 315-31. PMID 24142337 DOI: 10.1007/s10295-013-1361-8  1
2013 Sharma A, Blair PM, Mitchell DA. Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase. Organic Letters. 15: 5076-9. PMID 24063702 DOI: 10.1021/ol402444a  1
2013 Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA. Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12954-9. PMID 23878226 DOI: 10.1073/pnas.1306101110  1
2013 Deane CD, Melby JO, Molohon KJ, Susarrey AR, Mitchell DA. Engineering unnatural variants of plantazolicin through codon reprogramming. Acs Chemical Biology. 8: 1998-2008. PMID 23823732 DOI: 10.1021/cb4003392  1
2013 Dunbar KL, Mitchell DA. Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives. Journal of the American Chemical Society. 135: 8692-701. PMID 23721104 DOI: 10.1021/ja4029507  1
2013 Keller RK, Mitchell DA, Goulah CC, Fliesler SJ. Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome. Lipids. 48: 219-29. PMID 23361583 DOI: 10.1007/s11745-013-3762-x  0.92
2013 Hu Y, Jia S, Ren F, Huang CH, Ko TP, Mitchell DA, Guo RT, Zheng Y. Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 77-9. PMID 23295493 DOI: 10.1107/S1744309112049330  1
2013 Dunbar KL, Mitchell DA. Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis. Acs Chemical Biology. 8: 473-87. PMID 23286465 DOI: 10.1021/cb3005325  1
2013 Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, et al. Antibacterial drug leads targeting isoprenoid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 123-8. PMID 23248302 DOI: 10.1073/pnas.1219899110  0.36
2012 Mitchell DA, Hamel LD, Ishizuka K, Mitchell G, Schaefer LM, Deschenes RJ. The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate. The Journal of Biological Chemistry. 287: 34337-48. PMID 22904317 DOI: 10.1074/jbc.M112.379297  0.92
2012 Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, et al. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. Acs Medicinal Chemistry Letters. 3: 402-406. PMID 22662288 DOI: 10.1021/ml300038t  1
2012 Dunbar KL, Melby JO, Mitchell DA. YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. Nature Chemical Biology. 8: 569-75. PMID 22522320 DOI: 10.1038/nchembio.944  1
2012 Melby JO, Dunbar KL, Trinh NQ, Mitchell DA. Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase. Journal of the American Chemical Society. 134: 5309-16. PMID 22401305 DOI: 10.1021/ja211675n  1
2011 Molohon KJ, Melby JO, Lee J, Evans BS, Dunbar KL, Bumpus SB, Kelleher NL, Mitchell DA. Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. Acs Chemical Biology. 6: 1307-13. PMID 21950656 DOI: 10.1021/cb200339d  1
2011 Molloy EM, Cotter PD, Hill C, Mitchell DA, Ross RP. Streptolysin S-like virulence factors: the continuing sagA. Nature Reviews. Microbiology. 9: 670-81. PMID 21822292 DOI: 10.1038/nrmicro2624  1
2011 Pei J, Mitchell DA, Dixon JE, Grishin NV. Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1. Journal of Molecular Biology. 410: 18-26. PMID 21570408 DOI: 10.1016/j.jmb.2011.04.066  1
2011 Melby JO, Nard NJ, Mitchell DA. Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates. Current Opinion in Chemical Biology. 15: 369-78. PMID 21429787 DOI: 10.1016/j.cbpa.2011.02.027  1
2011 Scholz R, Molohon KJ, Nachtigall J, Vater J, Markley AL, Süssmuth RD, Mitchell DA, Borriss R. Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42. Journal of Bacteriology. 193: 215-24. PMID 20971906 DOI: 10.1128/JB.00784-10  1
2010 Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC. Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. The Journal of Biological Chemistry. 285: 28220-8. PMID 20581111 DOI: 10.1074/jbc.M110.118554  1
2010 Haft DH, Basu MK, Mitchell DA. Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family. Bmc Biology. 8: 70. PMID 20500830 DOI: 10.1186/1741-7007-8-70  1
2010 Mitchell DA, Ryabov AD, Kundu S, Chanda A, Collins TJ. Oxidation of pinacyanol chloride by H2O2 catalyzed by FeIII complexed to tetraamidomacrocyclic ligand: Unusual kinetics and product identification Journal of Coordination Chemistry. 63: 2605-2618. DOI: 10.1080/00958972.2010.492426  1
2009 Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. The Journal of Biological Chemistry. 284: 13004-12. PMID 19286651 DOI: 10.1074/jbc.M900802200  1
2008 Ghosh A, Mitchell DA, Chanda A, Ryabov AD, Popescu DL, Upham EC, Collins GJ, Collins TJ. Catalase-peroxidase activity of iron(III)-TAML activators of hydrogen peroxide. Journal of the American Chemical Society. 130: 15116-26. PMID 18928252 DOI: 10.1021/ja8043689  1
2008 Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 105: 5879-84. PMID 18375757 DOI: 10.1073/pnas.0801338105  1
2007 Mitchell DA, Morton SU, Fernhoff NB, Marletta MA. Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 11609-14. PMID 17606900 DOI: 10.1073/pnas.0704898104  1
2007 Chahbane N, Popescu DL, Mitchell DA, Chanda A, Lenoir D, Ryabov AD, Schramm KW, Collins TJ. FeIII-TAML-catalyzed green oxidative degradation of the azo dye Orange II by H2O2 and organic peroxides: Products, toxicity, kinetics, and mechanisms Green Chemistry. 9: 49-57. DOI: 10.1039/b604990g  1
2007 Mitchell DA, Michel T, Marletta MA. Effects of S-nitrosation of nitric oxide synthase Advances in Experimental Biology. 1: 151-179,456. DOI: 10.1016/S1872-2423(07)01007-1  1
2006 Mitchell DA, Morton SU, Marletta MA. Design and characterization of an active site selective caspase-3 transnitrosating agent. Acs Chemical Biology. 1: 659-65. PMID 17168570 DOI: 10.1021/cb600393x  1
2006 Erwin PA, Mitchell DA, Sartoretto J, Marletta MA, Michel T. Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 281: 151-7. PMID 16286475 DOI: 10.1074/jbc.M510421200  1
2005 Mitchell DA, Marletta MA. Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine. Nature Chemical Biology. 1: 154-8. PMID 16408020 DOI: 10.1038/nchembio720  1
2005 Mitchell DA, Erwin PA, Michel T, Marletta MA. S-Nitrosation and regulation of inducible nitric oxide synthase. Biochemistry. 44: 4636-47. PMID 15779890 DOI: 10.1021/bi0474463  1
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