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Paul J. Hergenrother - Publications

Chemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
synthetic organic chemistry, chemical biology, and biochemistry

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Garcia Chavez M, Garcia A, Lee HY, Lau GW, Parker EN, Komnick KE, Hergenrother PJ. Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile. Acs Infectious Diseases. PMID 33522241 DOI: 10.1021/acsinfecdis.0c00869  0.56
2020 Perlmutter SJ, Geddes EJ, Drown BS, Motika SE, Lee MR, Hergenrother PJ. Compound Uptake into Can Be Facilitated by -Alkyl Guanidiniums and Pyridiniums. Acs Infectious Diseases. PMID 33228356 DOI: 10.1021/acsinfecdis.0c00715  1
2020 Motika SE, Hergenrother PJ. Re-engineering natural products to engage new biological targets. Natural Product Reports. PMID 33034322 DOI: 10.1039/d0np00059k  0.48
2020 Motika SE, Ulrich RJ, Geddes EJ, Lee HY, Lau GW, Hergenrother PJ. A Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch. Journal of the American Chemical Society. PMID 32432858 DOI: 10.1021/jacs.0c04427  0.48
2019 Parker EN, Drown BS, Geddes EJ, Lee HY, Ismail N, Lau GW, Hergenrother PJ. Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens. Nature Microbiology. PMID 31740764 DOI: 10.1038/s41564-019-0604-5  1
2019 Janin M, Ortiz-Barahona V, de Moura MC, Martínez-Cardús A, Llinàs-Arias P, Soler M, Nachmani D, Pelletier J, Schumann U, Calleja-Cervantes ME, Moran S, Guil S, Bueno-Costa A, Piñeyro D, Perez-Salvia M, ... ... Hergenrother PJ, et al. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. Acta Neuropathologica. PMID 31428936 DOI: 10.1007/s00401-019-02062-4  0.52
2019 Boudreau MW, Peh J, Hergenrother PJ. Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential. Acs Chemical Biology. PMID 31260254 DOI: 10.1021/acschembio.9b00338  0.52
2019 Llabani E, Hicklin RW, Lee HY, Motika SE, Crawford LA, Weerapana E, Hergenrother PJ. Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis. Nature Chemistry. PMID 31086302 DOI: 10.1038/s41557-019-0261-6  0.8
2019 Schlein LJ, Fadl-Alla B, Pondenis HC, Lezmi S, Eberhart CG, LeBlanc AK, Dickinson PJ, Hergenrother PJ, Fan TM. Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers. Frontiers in Oncology. 9: 96. PMID 30859090 DOI: 10.3389/fonc.2019.00096  0.6
2018 Rack JGM, Ariza A, Drown BS, Henfrey C, Bartlett E, Shirai T, Hergenrother PJ, Ahel I. (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Cell Chemical Biology. 25: 1533-1546.e12. PMID 30472116 DOI: 10.1016/j.chembiol.2018.11.001  1
2018 Drown BS, Shirai T, Rack JGM, Ahel I, Hergenrother PJ. Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate. Cell Chemical Biology. PMID 30318463 DOI: 10.1016/j.chembiol.2018.09.008  1
2018 Svec RL, Furiassi L, Skibinski CG, Fan TM, Riggins GJ, Hergenrother PJ. Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma. Acs Chemical Biology. PMID 30296373 DOI: 10.1021/acschembio.8b00864  0.6
2018 Tasker SZ, Cowfer AE, Hergenrother PJ. Preparation of Structurally Diverse Compounds from the Natural Product Lycorine. Organic Letters. 20: 5894-5898. PMID 30204451 DOI: 10.1021/acs.orglett.8b02562  0.32
2018 Peh J, Boudreau MW, Smith HM, Hergenrother PJ. Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation. Cell Chemical Biology. PMID 29909991 DOI: 10.1016/j.chembiol.2018.05.008  0.52
2018 Drown BS, Hergenrother PJ. Going on offense against the gram-negative defense. Proceedings of the National Academy of Sciences of the United States of America. PMID 29802227 DOI: 10.1073/pnas.1807278115  1
2018 Richter MF, Hergenrother PJ. The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics. Annals of the New York Academy of Sciences. PMID 29446459 DOI: 10.1111/nyas.13598  0.48
2017 Joshi AD, Botham RC, Schlein LJ, Roth HS, Mangraviti A, Borodovsky A, Tyler B, Joslyn S, Looper JS, Podell M, Fan TM, Hergenrother PJ, Riggins GJ. Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients. Oncotarget. 8: 80124-80138. PMID 29113289 DOI: 10.18632/oncotarget.19085  0.92
2017 Doğanay S, Lee MY, Baum A, Peh J, Hwang SY, Yoo JY, Hergenrother PJ, García-Sastre A, Myong S, Ha T. Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 29098213 DOI: 10.1039/c7ib00146k  0.52
2017 Joshi AD, Botham RC, Schlein LJ, Roth HS, Mangraviti A, Borodovsky A, Tyler B, Joslyn S, Looper JS, Podell M, Fan TM, Hergenrother PJ, Riggins GJ. Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients. Oncotarget. PMID 28708601 DOI: 10.18632/oncotarget.19085  0.92
2017 Granchi C, Fortunato S, Meini S, Rizzolio F, Caligiuri I, Tuccinardi T, Lee HY, Hergenrother PJ, Minutolo F. Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer. Journal of Agricultural and Food Chemistry. PMID 28643510 DOI: 10.1021/acs.jafc.7b01668  0.44
2017 Tasker SZ, Hergenrother PJ. Natural products: Taming reactive benzynes. Nature Chemistry. 9: 504-506. PMID 28537601 DOI: 10.1038/nchem.2786  0.32
2017 Richter MF, Drown BS, Riley AP, Garcia A, Shirai T, Svec RL, Hergenrother PJ. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature. PMID 28489819 DOI: 10.1038/nature22308  1
2016 Lundberg AP, Francis JM, Pajak M, Parkinson EI, Wycislo KL, Rosol TJ, Brown ME, London CA, Dirikolu L, Hergenrother PJ, Fan TM. Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species. Investigational New Drugs. PMID 27975234 DOI: 10.1007/s10637-016-0414-z  0.88
2016 Garcia A, Drown BS, Hergenrother PJ. Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine. Organic Letters. PMID 27650404 DOI: 10.1021/acs.orglett.6b02333  1
2016 Huang Q, Peh J, Hergenrother PJ, Cunningham BT. Porous photonic crystal external cavity laser biosensor. Applied Physics Letters. 109: 071103. PMID 27647941 DOI: 10.1063/1.4961107  0.52
2016 Botham RC, Roth HS, Book AP, Roady PJ, Fan TM, Hergenrother PJ. Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics. Acs Central Science. 2: 545-59. PMID 27610416 DOI: 10.1021/acscentsci.6b00165  0.92
2016 Peh J, Fan TM, Wycislo KL, Roth HS, Hergenrother PJ. The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas. Molecular Cancer Therapeutics. PMID 27297867 DOI: 10.1158/1535-7163.MCT-16-0025  0.6
2016 Luu LM, Nguyen L, Peng S, Lee J, Lee HY, Wong CH, Hergenrother PJ, Chan HY, Zimmerman SC. A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy. Chemmedchem. PMID 27245480 DOI: 10.1002/cmdc.201600081  1
2015 Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Reports. 13: 2027-2036. PMID 26655912 DOI: 10.1016/j.celrep.2015.10.042  1
2015 Roth HS, Hergenrother PJ. Derivatives of Procaspase-Activating Compound 1 (PAC-1) and Their Anticancer Activities. Current Medicinal Chemistry. PMID 26630918  1
2015 Wallace HM, Hergenrother PJ, Sadler PJ. Molecular medicine and cancer. Chemical Society Reviews. PMID 26595319 DOI: 10.1039/c5cs90123e  1
2015 Parkinson EI, Hergenrother PJ. Deoxynyboquinones as NQO1-Activated Cancer Therapeutics. Accounts of Chemical Research. 48: 2715-23. PMID 26444384 DOI: 10.1021/acs.accounts.5b00365  1
2015 Granchi C, Qian Y, Lee HY, Paterni I, Pasero C, Iegre J, Carlson KE, Tuccinardi T, Chen X, Katzenellenbogen JA, Hergenrother PJ, Minutolo F. Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells. Chemmedchem. PMID 26332543 DOI: 10.1002/cmdc.201500320  1
2015 Di Bussolo V, Calvaresi EC, Granchi C, Del Bino L, Frau I, Lang MC, Tuccinardi T, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents. Rsc Advances. 5: 19944-19954. PMID 26167277 DOI: 10.1039/C5RA00946D  1
2015 Parkinson EI, Bair JS, Nakamura BA, Lee HY, Kuttab HI, Southgate EH, Lezmi S, Lau GW, Hergenrother PJ. Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nature Communications. 6: 6947. PMID 25907309 DOI: 10.1038/ncomms7947  1
2015 Roth HS, Botham RC, Schmid SC, Fan TM, Dirikolu L, Hergenrother PJ. Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics. Journal of Medicinal Chemistry. 58: 4046-65. PMID 25856364 DOI: 10.1021/acs.jmedchem.5b00413  1
2015 Lambrecht MJ, Brichacek M, Barkauskaite E, Ariza A, Ahel I, Hergenrother PJ. Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase. Journal of the American Chemical Society. 137: 3558-64. PMID 25706250 DOI: 10.1021/ja512528p  1
2015 Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, vanHam TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed Cell Reports. DOI: 10.1016/j.celrep.2015.10.042  1
2014 Meng Zhang, Peh J, Hergenrother PJ, Cunningham BT. Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2014: 2073-6. PMID 25570392 DOI: 10.1109/EMBC.2014.6944024  1
2014 Hicklin RW, López Silva TL, Hergenrother PJ. Synthesis of bridged oxafenestranes from pleuromutilin. Angewandte Chemie (International Ed. in English). 53: 9880-3. PMID 25045118 DOI: 10.1002/anie.201404765  1
2014 Zhang M, Peh J, Hergenrother PJ, Cunningham BT. Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor. Journal of the American Chemical Society. 136: 5840-3. PMID 24720510 DOI: 10.1021/ja500636p  1
2014 Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM, Hergenrother PJ, Zimmerman SC. Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor. Journal of the American Chemical Society. 136: 6355-61. PMID 24702247 DOI: 10.1021/ja5012146  1
2014 Botham RC, Fan TM, Im I, Borst LB, Dirikolu L, Hergenrother PJ. Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity. Journal of the American Chemical Society. 136: 1312-9. PMID 24383395 DOI: 10.1021/ja4124303  1
2014 Larson AS, Hergenrother PJ. Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity. Biochemistry. 53: 188-201. PMID 24279911 DOI: 10.1021/bi4008098  1
2014 Rafferty RJ, Hicklin RW, Maloof KA, Hergenrother PJ. Synthesis of complex and diverse compounds through ring distortion of abietic acid. Angewandte Chemie (International Ed. in English). 53: 220-4. PMID 24273016 DOI: 10.1002/anie.201308743  1
2014 Morrison KC, Hergenrother PJ. Natural products as starting points for the synthesis of complex and diverse compounds. Natural Product Reports. 31: 6-14. PMID 24219884 DOI: 10.1039/c3np70063a  1
2014 Han S, Morrison KC, Hergenrother PJ, Movassaghi M. Total synthesis, stereochemical assignment, and biological activity of all known (-)-trigonoliimines. The Journal of Organic Chemistry. 79: 473-86. PMID 24127681 DOI: 10.1021/jo4020358  1
2013 Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens RW, Lee HY, Palchaudhuri R, Macchia M, Martinelli A, Minutolo F, Hergenrother PJ. Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem : a European Journal of Chemical Biology. 14: 2263-7. PMID 24174263 DOI: 10.1002/cbic.201300562  1
2013 Han S, Siegel DS, Morrison KC, Hergenrother PJ, Movassaghi M. Synthesis and anticancer activity of all known (-)-agelastatin alkaloids. The Journal of Organic Chemistry. 78: 11970-84. PMID 24152243 DOI: 10.1021/jo4020112  1
2013 Calvaresi EC, Hergenrother PJ. Glucose conjugation for the specific targeting and treatment of cancer. Chemical Science (Royal Society of Chemistry : 2010). 4: 2319-2333. PMID 24077675 DOI: 10.1039/C3SC22205E  1
2013 van Rensburg JJ, Hergenrother PJ. Detection of endogenous MazF enzymatic activity in Staphylococcus aureus. Analytical Biochemistry. 443: 81-7. PMID 23994560 DOI: 10.1016/j.ab.2013.08.018  1
2013 Granchi C, Calvaresi EC, Tuccinardi T, Paterni I, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Organic & Biomolecular Chemistry. 11: 6588-96. PMID 23986182 DOI: 10.1039/c3ob40870a  1
2013 Granger BA, Jewett IT, Butler JD, Hua B, Knezevic CE, Parkinson EI, Hergenrother PJ, Martin SF. Synthesis of (±)-actinophyllic acid and analogs: applications of cascade reactions and diverted total synthesis. Journal of the American Chemical Society. 135: 12984-6. PMID 23972114 DOI: 10.1021/ja4070206  1
2013 Parkinson EI, Bair JS, Cismesia M, Hergenrother PJ. Efficient NQO1 substrates are potent and selective anticancer agents. Acs Chemical Biology. 8: 2173-83. PMID 23937670 DOI: 10.1021/cb4005832  1
2013 Boyer N, Morrison KC, Kim J, Hergenrother PJ, Movassaghi M. Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids. Chemical Science (Royal Society of Chemistry : 2010). 4: 1646-1657. PMID 23914293 DOI: 10.1039/C3SC50174D  1
2013 Ge C, Lu M, George S, Flood TA, Wagner C, Zheng J, Pokhriyal A, Eden JG, Hergenrother PJ, Cunningham BT. External cavity laser biosensor. Lab On a Chip. 13: 1247-56. PMID 23429747 DOI: 10.1039/c3lc41330f  1
2013 Huigens RW, Morrison KC, Hicklin RW, Flood TA, Richter MF, Hergenrother PJ. A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products. Nature Chemistry. 5: 195-202. PMID 23422561 DOI: 10.1038/nchem.1549  1
2012 Dunstan MS, Barkauskaite E, Lafite P, Knezevic CE, Brassington A, Ahel M, Hergenrother PJ, Leys D, Ahel I. Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase. Nature Communications. 3: 878. PMID 22673905 DOI: 10.1038/ncomms1889  1
2012 Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA. An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis. Cancer Research. 72: 3038-47. PMID 22532167 DOI: 10.1158/0008-5472.CAN-11-3135  1
2012 West DC, Qin Y, Peterson QP, Thomas DL, Palchaudhuri R, Morrison KC, Lucas PW, Palmer AE, Fan TM, Hergenrother PJ. Differential effects of procaspase-3 activating compounds in the induction of cancer cell death. Molecular Pharmaceutics. 9: 1425-34. PMID 22486564 DOI: 10.1021/mp200673n  1
2012 Williams JJ, Hergenrother PJ. Artificial activation of toxin-antitoxin systems as an antibacterial strategy. Trends in Microbiology. 20: 291-8. PMID 22445361 DOI: 10.1016/j.tim.2012.02.005  1
2012 Eibergen NR, Im I, Patel NY, Hergenrother PJ. Identification of a novel protein synthesis inhibitor active against gram-positive bacteria. Chembiochem : a European Journal of Chemical Biology. 13: 574-83, 490. PMID 22362659 DOI: 10.1002/cbic.201100727  1
2012 Finch KE, Knezevic CE, Nottbohm AC, Partlow KC, Hergenrother PJ. Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG). Acs Chemical Biology. 7: 563-70. PMID 22220926 DOI: 10.1021/cb200506t  1
2012 Hsu DC, Roth HS, West DC, Botham RC, Novotny CJ, Schmid SC, Hergenrother PJ. Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1). Acs Combinatorial Science. 14: 44-50. PMID 22007686 DOI: 10.1021/co2001372  1
2012 Morrison KC, Hergenrother PJ. Whole cell microtubule analysis by flow cytometry. Analytical Biochemistry. 420: 26-32. PMID 21893022 DOI: 10.1016/j.ab.2011.08.020  1
2011 Parkinson EI, Hergenrother PJ. Runaway ROS as a selective anticancer strategy. Chemmedchem. 6: 1957-9. PMID 21898834 DOI: 10.1002/cmdc.201100381  1
2011 Williams JJ, Halvorsen EM, Dwyer EM, DiFazio RM, Hergenrother PJ. Toxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Fems Microbiology Letters. 322: 41-50. PMID 21658105 DOI: 10.1111/j.1574-6968.2011.02330.x  1
2011 Risberg K, Guldvik IJ, Palchaudhuri R, Xi Y, Ju J, Fodstad O, Hergenrother PJ, Andersson Y. Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins. Journal of Immunotherapy (Hagerstown, Md. : 1997). 34: 438-47. PMID 21577141 DOI: 10.1097/CJI.0b013e31821e00ae  1
2011 Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, ... ... Hergenrother PJ, et al. Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. Journal of Medicinal Chemistry. 54: 1599-612. PMID 21332213 DOI: 10.1021/jm101007q  1
2011 Heeres JT, Hergenrother PJ. High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies. Chemical Society Reviews. 40: 4398-410. PMID 21140010 DOI: 10.1039/b923660k  1
2011 Palchaudhuri R, Hergenrother PJ. Transcript profiling and RNA interference as tools to identify small molecule mechanisms and therapeutic potential. Acs Chemical Biology. 6: 21-33. PMID 21105689 DOI: 10.1021/cb100310h  1
2011 Halvorsen EM, Williams JJ, Bhimani AJ, Billings EA, Hergenrother PJ. Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis. Microbiology (Reading, England). 157: 387-97. PMID 21030436 DOI: 10.1099/mic.0.045492-0  1
2011 Lucas PW, Schmit JM, Peterson QP, West DC, Hsu DC, Novotny CJ, Dirikolu L, Churchwell MI, Doerge DR, Garrett LD, Hergenrother PJ, Fan TM. Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs. Investigational New Drugs. 29: 901-11. PMID 20499133 DOI: 10.1007/s10637-010-9445-z  1
2011 Hoyt MT, Palchaudhuri R, Hergenrother PJ. Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism. Investigational New Drugs. 29: 562-73. PMID 20169400 DOI: 10.1007/s10637-010-9390-x  1
2010 Kretzer NM, Cherian MT, Mao C, Aninye IO, Reynolds PD, Schiff R, Hergenrother PJ, Nordeen SK, Wilson EM, Shapiro DJ. A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}. The Journal of Biological Chemistry. 285: 41863-73. PMID 21041310 DOI: 10.1074/jbc.M110.183723  1
2010 Peterson QP, Hsu DC, Novotny CJ, West DC, Kim D, Schmit JM, Dirikolu L, Hergenrother PJ, Fan TM. Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound. Cancer Research. 70: 7232-41. PMID 20823163 DOI: 10.1158/0008-5472.CAN-10-0766  1
2010 Guan Y, Omueti-Ayoade K, Mutha SK, Hergenrother PJ, Tapping RI. Identification of novel synthetic toll-like receptor 2 agonists by high throughput screening. The Journal of Biological Chemistry. 285: 23755-62. PMID 20504771 DOI: 10.1074/jbc.M110.116046  1
2010 Leslie BJ, Holaday CR, Nguyen T, Hergenrother PJ. Phenylcinnamides as novel antimitotic agents. Journal of Medicinal Chemistry. 53: 3964-72. PMID 20411988 DOI: 10.1021/jm901805m  1
2010 Bair JS, Palchaudhuri R, Hergenrother PJ. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death. Journal of the American Chemical Society. 132: 5469-78. PMID 20345134 DOI: 10.1021/ja100610m  1
2010 Stefely JA, Palchaudhuri R, Miller PA, Peterson RJ, Moraski GC, Hergenrother PJ, Miller MJ. N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines. Journal of Medicinal Chemistry. 53: 3389-95. PMID 20334421 DOI: 10.1021/jm1000979  1
2010 Peterson QP, Goode DR, West DC, Botham RC, Hergenrother PJ. Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis. Nature Protocols. 5: 294-302. PMID 20134429 DOI: 10.1038/nprot.2009.223  1
2009 Chan LL, Lidstone EA, Finch KE, Heeres JT, Hergenrother PJ, Cunningham BT. A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates. Jala (Charlottesville, Va.). 14: 348-359. PMID 20930952 DOI: 10.1016/j.jala.2009.06.008  1
2009 Heeres JT, Kim SH, Leslie BJ, Lidstone EA, Cunningham BT, Hergenrother PJ. Identifying modulators of protein-protein interactions using photonic crystal biosensors. Journal of the American Chemical Society. 131: 18202-3. PMID 19968284 DOI: 10.1021/ja907066r  1
2009 Chan LL, Lidstone EA, Finch KE, Heeres JT, Hergenrother PJ, Cunningham BT. A method for identifying small molecule aggregators using photonic crystal biosensor microplates. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 788-91. PMID 19964243 DOI: 10.1109/IEMBS.2009.5333796  1
2009 Peterson QP, Hsu DC, Goode DR, Novotny CJ, Totten RK, Hergenrother PJ. Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. Journal of Medicinal Chemistry. 52: 5721-31. PMID 19708658 DOI: 10.1021/jm900722z  1
2009 Meyer ST, Hergenrother PJ. Small molecule ligands for bulged RNA secondary structures. Organic Letters. 11: 4052-5. PMID 19678613 DOI: 10.1021/ol901478x  1
2009 Peterson QP, Goode DR, West DC, Ramsey KN, Lee JJ, Hergenrother PJ. PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. Journal of Molecular Biology. 388: 144-58. PMID 19281821 DOI: 10.1016/j.jmb.2009.03.003  1
2009 Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. Journal of Medicinal Chemistry. 52: 1198-203. PMID 19186946 DOI: 10.1021/jm801484v  1
2009 Thompson CM, Quinn CA, Hergenrother PJ. Total synthesis and cytoprotective properties of dykellic acid. Journal of Medicinal Chemistry. 52: 117-25. PMID 19072121 DOI: 10.1021/jm801169s  1
2008 Palchaudhuri R, Hergenrother PJ. Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells. Bioorganic & Medicinal Chemistry Letters. 18: 5888-91. PMID 18710803 DOI: 10.1016/j.bmcl.2008.07.128  1
2008 Williams JJ, Hergenrother PJ. Exposing plasmids as the Achilles' heel of drug-resistant bacteria. Current Opinion in Chemical Biology. 12: 389-99. PMID 18625335 DOI: 10.1016/j.cbpa.2008.06.015  1
2008 Palchaudhuri R, Nesterenko V, Hergenrother PJ. The complex role of the triphenylmethyl motif in anticancer compounds. Journal of the American Chemical Society. 130: 10274-81. PMID 18611022 DOI: 10.1021/ja8020999  1
2008 Chan LL, Pineda M, Heeres JT, Hergenrother PJ, Cunningham BT. A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors. Acs Chemical Biology. 3: 437-48. PMID 18582039 DOI: 10.1021/cb800057j  1
2008 Leslie BJ, Hergenrother PJ. Identification of the cellular targets of bioactive small organic molecules using affinity reagents. Chemical Society Reviews. 37: 1347-60. PMID 18568161 DOI: 10.1039/b702942j  1
2008 Goode DR, Totten RK, Heeres JT, Hergenrother PJ. Identification of promiscuous small molecule activators in high-throughput enzyme activation screens. Journal of Medicinal Chemistry. 51: 2346-9. PMID 18366176 DOI: 10.1021/jm701583b  1
2008 Thomas JR, Hergenrother PJ. Targeting RNA with small molecules. Chemical Reviews. 108: 1171-224. PMID 18361529 DOI: 10.1021/cr0681546  1
2008 Mao C, Patterson NM, Cherian MT, Aninye IO, Zhang C, Montoya JB, Cheng J, Putt KS, Hergenrother PJ, Wilson EM, Nardulli AM, Nordeen SK, Shapiro DJ. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. The Journal of Biological Chemistry. 283: 12819-30. PMID 18337247 DOI: 10.1074/jbc.M709936200  1
2008 Musk DJ, Hergenrother PJ. Chelated iron sources are inhibitors of Pseudomonas aeruginosa biofilms and distribute efficiently in an in vitro model of drug delivery to the human lung. Journal of Applied Microbiology. 105: 380-8. PMID 18284482 DOI: 10.1111/j.1365-2672.2008.03751.x  1
2008 Cunningham BT, Chan L, Mathias PC, Ganesh N, George S, Lidstone E, Heeres J, Hergenrother PJ. Photonic crystals: A platform for label-free and enhanced fluorescence biomolecular and cellular assays Materials Research Society Symposium Proceedings. 1133: 43-52.  1
2007 Palchaudhuri R, Hergenrother PJ. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action. Current Opinion in Biotechnology. 18: 497-503. PMID 17988854 DOI: 10.1016/j.copbio.2007.09.006  1
2007 Heeres JT, Hergenrother PJ. Poly(ADP-ribose) makes a date with death. Current Opinion in Chemical Biology. 11: 644-53. PMID 17936669 DOI: 10.1016/j.cbpa.2007.08.038  1
2007 Wang NR, Hergenrother PJ. A continuous fluorometric assay for the assessment of MazF ribonuclease activity. Analytical Biochemistry. 371: 173-83. PMID 17706586 DOI: 10.1016/j.ab.2007.07.017  1
2007 Yu KN, Lee SM, Han JY, Park H, Woo MA, Noh MS, Hwang SK, Kwon JT, Jin H, Kim YK, Hergenrother PJ, Jeong DH, Lee YS, Cho MH. Multiplex targeting, tracking, and imaging of apoptosis by fluorescent surface enhanced Raman spectroscopic dots. Bioconjugate Chemistry. 18: 1155-62. PMID 17602510 DOI: 10.1021/bc070011i  1
2007 Skarda DE, Putt KS, Hergenrother PJ, Mulier KE, Beilman GJ. Increased poly(ADP-ribose) polymerase activity during porcine hemorrhagic shock is transient and predictive of mortality. Resuscitation. 75: 135-44. PMID 17467870 DOI: 10.1016/j.resuscitation.2007.02.020  1
2007 Nottbohm AC, Dothager RS, Putt KS, Hoyt MT, Hergenrother PJ. A colorimetric substrate for poly(ADP-ribose) polymerase-1, VPARP, and tankyrase-1. Angewandte Chemie (International Ed. in English). 46: 2066-9. PMID 17299820 DOI: 10.1002/anie.200603988  1
2007 Moritz EM, Hergenrother PJ. Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci. Proceedings of the National Academy of Sciences of the United States of America. 104: 311-6. PMID 17190821 DOI: 10.1073/pnas.0601168104  1
2007 Sienkiewicz P, Ciolino HP, Leslie BJ, Hergenrother PJ, Singletary K, Yeh GC. A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor. Carcinogenesis. 28: 1052-7. PMID 17183067 DOI: 10.1093/carcin/bgl248  1
2007 Hergenrother PJ, Putt KS, Sandhorst JS. Reply to 'small molecules not direct activators of caspases' [2] Nature Chemical Biology. 3: 520. DOI: 10.1038/nchembio0907-520  1
2007 Breton P, Hergenrother PJ, Hida T, Hodgson A, Judd AS, Kraynack E, Kym PR, Lee WC, Loft MS, Yamashita M, Martin SF. Total synthesis of erythromycin B Tetrahedron. 63: 5709-5729. DOI: 10.1016/j.tet.2007.02.044  1
2006 Putt KS, Nesterenko V, Dothager RS, Hergenrother PJ. The compound 13-D selectively induces apoptosis in white blood cancers versus other cancer cell types. Chembiochem : a European Journal of Chemical Biology. 7: 1916-22. PMID 17051660 DOI: 10.1002/cbic.200600228  1
2006 Thomas JR, Liu X, Hergenrother PJ. Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: toward an understanding of selectivity. Biochemistry. 45: 10928-38. PMID 16953578 DOI: 10.1021/bi0607296  1
2006 Putt KS, Chen GW, Pearson JM, Sandhorst JS, Hoagland MS, Kwon JT, Hwang SK, Jin H, Churchwell MI, Cho MH, Doerge DR, Helferich WG, Hergenrother PJ. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nature Chemical Biology. 2: 543-50. PMID 16936720 DOI: 10.1038/nchembio814  1
2006 Musk DJ, Hergenrother PJ. Chemical countermeasures for the control of bacterial biofilms: effective compounds and promising targets. Current Medicinal Chemistry. 13: 2163-77. PMID 16918346 DOI: 10.2174/092986706777935212  1
2006 Hergenrother PJ. Obtaining and screening compound collections: a user's guide and a call to chemists. Current Opinion in Chemical Biology. 10: 213-8. PMID 16677847 DOI: 10.1016/j.cbpa.2006.04.005  1
2006 Silverman SK, Hergenrother PJ. Combinatorial chemistry and molecular diversity. Tools for molecular diversification and their applications in chemical biology Current Opinion in Chemical Biology. 10: 185-187. DOI: 10.1016/j.cbpa.2006.04.024  1
2006 Nottbohm AC, Hergenrother PJ. The Promises and Pitfalls of Small-Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG) Drug Discovery Research: New Frontiers in the Post-Genomic Era. 163-185. DOI: 10.1002/9780470131862.ch7  1
2005 Thomas JR, Liu X, Hergenrother PJ. Size-specific ligands for RNA hairpin loops. Journal of the American Chemical Society. 127: 12434-5. PMID 16144359 DOI: 10.1021/ja051685b  1
2005 Goode DR, Sharma AK, Hergenrother PJ. Using peptidic inhibitors to systematically probe the S1' site of caspase-3 and caspase-7. Organic Letters. 7: 3529-32. PMID 16048334 DOI: 10.1021/ol051287d  1
2005 Musk DJ, Banko DA, Hergenrother PJ. Iron salts perturb biofilm formation and disrupt existing biofilms of Pseudomonas aeruginosa. Chemistry & Biology. 12: 789-96. PMID 16039526 DOI: 10.1016/j.chembiol.2005.05.007  1
2005 Dothager RS, Putt KS, Allen BJ, Leslie BJ, Nesterenko V, Hergenrother PJ. Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest. Journal of the American Chemical Society. 127: 8686-96. PMID 15954774 DOI: 10.1021/ja042913p  1
2005 Thomas JR, DeNap JC, Wong ML, Hergenrother PJ. The relationship between aminoglycosides' RNA binding proclivity and their antiplasmid effect on an IncB plasmid. Biochemistry. 44: 6800-8. PMID 15865425 DOI: 10.1021/bi0473298  1
2005 DeNap JC, Hergenrother PJ. Bacterial death comes full circle: targeting plasmid replication in drug-resistant bacteria. Organic & Biomolecular Chemistry. 3: 959-66. PMID 15750634 DOI: 10.1039/b500182j  1
2005 Putt KS, Beilman GJ, Hergenrother PJ. Direct quantitation of poly(ADP-ribose) polymerase (PARP) activity as a means to distinguish necrotic and apoptotic death in cell and tissue samples. Chembiochem : a European Journal of Chemical Biology. 6: 53-5. PMID 15549722 DOI: 10.1002/cbic.200400330  1
2005 Toepke MW, Block ID, Nesterenko V, Choi CJ, Schudel B, Cunningham BT, Hergenrother PJ, Kenis PJA. Microfluidics for combinatorial synthesis and screening on chip Aiche Annual Meeting, Conference Proceedings. 12668.  1
2005 Baudry J, Hergenrother PJ. Structure-based design and in silico virtual screening of combinatorial libraries: A combined chemical-computational project Journal of Chemical Education. 82: 890-894.  1
2004 Denap JC, Thomas JR, Musk DJ, Hergenrother PJ. Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds. Journal of the American Chemical Society. 126: 15402-4. PMID 15563166 DOI: 10.1021/ja044207u  1
2004 Putt KS, Hergenrother PJ. A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation. Analytical Biochemistry. 333: 256-64. PMID 15450800 DOI: 10.1016/j.ab.2004.04.032  1
2004 Liu X, Thomas JR, Hergenrother PJ. Deoxystreptamine dimers bind to RNA hairpin loops. Journal of the American Chemical Society. 126: 9196-7. PMID 15281805 DOI: 10.1021/ja048936l  1
2004 Putt KS, Hergenrother PJ. An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors. Analytical Biochemistry. 326: 78-86. PMID 14769338 DOI: 10.1016/j.ab.2003.11.015  1
2003 Nesterenko V, Putt KS, Hergenrother PJ. Identification from a combinatorial library of a small molecule that selectively induces apoptosis in cancer cells. Journal of the American Chemical Society. 125: 14672-3. PMID 14640619 DOI: 10.1021/ja038043d  1
2003 Hergenrother PJ, Hodgson A, Judd AS, Lee WC, Martin SF. An abiotic strategy for the enantioselective synthesis of erythromycin B. Angewandte Chemie (International Ed. in English). 42: 3278-81. PMID 12876743 DOI: 10.1002/anie.200351136  1
2003 Sharma AK, Hergenrother PJ. Efficient synthesis of enantiopure beta-amino-gamma-keto acids from l-homoserine. Organic Letters. 5: 2107-9. PMID 12790540 DOI: 10.1021/ol0345327  1
2003 Antikainen NM, Hergenrother PJ, Harris MM, Corbett W, Martin SF. Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site. Biochemistry. 42: 1603-10. PMID 12578373 DOI: 10.1021/bi0267285  1
2003 Nesterenko V, Byers JT, Hergenrother PJ. The use of pH to influence regio- and chemoselectivity in the asymmetric aminohydroxylation of styrenes. Organic Letters. 5: 281-4. PMID 12556172 DOI: 10.1021/ol027242j  1
2002 Crowe MC, Brodbelt JS, Goolsby BJ, Hergenrother P. Characterization of erythromycin analogs by collisional activated dissociation and infrared multiphoton dissociation in a quadrupole ion trap. Journal of the American Society For Mass Spectrometry. 13: 630-49. PMID 12056564 DOI: 10.1016/S1044-0305(02)00366-5  1
2002 Kuruvilla FG, Shamji AF, Sternson SM, Hergenrother PJ, Schreiber SL. Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature. 416: 653-7. PMID 11948353 DOI: 10.1038/416653a  1
2000 Martin SF, Follows BC, Hergenrother PJ, Franklin CL. A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. The Journal of Organic Chemistry. 65: 4509-14. PMID 10959851 DOI: 10.1021/jo9915731  1
2000 Martin SF, Follows BC, Hergenrother PJ, Trotter BK. The choline binding site of phospholipase C (Bacillus cereus): insights into substrate specificity. Biochemistry. 39: 3410-5. PMID 10727235 DOI: 10.1021/bi9919798  1
2000 Martin SF, DeBlanc RL, Hergenrother PJ. Determination of the substrate specificity of the phospholipase D from Streptomyces chromofuscus via an inorganic phosphate quantitation assay. Analytical Biochemistry. 278: 106-10. PMID 10660451 DOI: 10.1006/abio.1999.4420  1
2000 Hergenrother PJ, Depew KM, Schreiber SL. Small-molecule microarrays: Covalent attachment and screening of alcohol-containing small molecules on glass slides [20] Journal of the American Chemical Society. 122: 7849-7850. DOI: 10.1021/ja0014032  1
1999 Martin SF, Hergenrother PJ. Catalytic cycle of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus. Solvent viscosity, deuterium isotope effects, and proton inventory studies. Biochemistry. 38: 4403-8. PMID 10194360 DOI: 10.1021/bi9821216  1
1998 Martin SF, Hergenrother PJ. Enzymatic synthesis of a modified phospholipid and its evaluation as a substrate for B. cereus phospholipase C. Bioorganic & Medicinal Chemistry Letters. 8: 593-6. PMID 9871566 DOI: 10.1016/S0960-894X(98)00071-7  1
1998 Martin SF, Hergenrother PJ. General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: the role of Glu4 and Asp55. Biochemistry. 37: 5755-60. PMID 9548962 DOI: 10.1021/bi972948k  1
1997 Hergenrother PJ, Martin SF. Determination of the kinetic parameters for phospholipase C (Bacillus cereus) on different phospholipid substrates using a chromogenic assay based on the quantitation of inorganic phosphate. Analytical Biochemistry. 251: 45-9. PMID 9300081 DOI: 10.1006/abio.1997.2251  1
1997 Hergenrother PJ, Haas MK, Martin SF. Chromogenic assay for phospholipase D from Streptomyces chromofuscus: application to the evaluation of substrate analogs. Lipids. 32: 783-8. PMID 9252969 DOI: 10.1007/s11745-997-0101-5  1
1996 Martin SF, Spaller MR, Hergenrother PJ. Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146. Biochemistry. 35: 12970-7. PMID 8841144 DOI: 10.1021/bi961316f  1
1995 Hergenrother PJ, Spaller MR, Haas MK, Martin SF. Chromogenic assay for phospholipase C from Bacillus cereus. Analytical Biochemistry. 229: 313-6. PMID 7485988 DOI: 10.1006/abio.1995.1418  1
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