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Christopher P. Landowski, Ph.D. - Publications

Affiliations: 
2005 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacy, Oncology
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Dahan A, Wolk O, Yang P, Mittal S, Wu Z, Landowski CP, Amidon GL. Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers. Molecular Pharmaceutics. 11: 4385-94. PMID 25365774 DOI: 10.1021/Mp500483V  0.613
2009 Foster DR, Landowski CP, Zheng X, Amidon GL, Welage LS. Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers. Pharmacological Research. 59: 215-20. PMID 19084598 DOI: 10.1016/J.Phrs.2008.11.001  0.543
2008 Tsume Y, Vig BS, Sun J, Landowski CP, Hilfinger JM, Ramachandran C, Amidon GL. Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters. Molecules (Basel, Switzerland). 13: 1441-54. PMID 18719516 DOI: 10.3390/Molecules13071441  0.741
2008 Bolanz KA, Hediger MA, Landowski CP. The role of TRPV6 in breast carcinogenesis. Molecular Cancer Therapeutics. 7: 271-9. PMID 18245667 DOI: 10.1158/1535-7163.Mct-07-0478  0.307
2007 Kim HR, Park SW, Cho HJ, Chae KA, Sung JM, Kim JS, Landowski CP, Sun D, Abd El-Aty AM, Amidon GL, Shin HC. Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacological Research. 56: 224-36. PMID 17681807 DOI: 10.1016/J.Phrs.2007.06.005  0.663
2007 Mittal S, Tsume Y, Landowski CP, Lee KD, Hilfinger JM, Amidon GL. Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 67: 752-8. PMID 17560100 DOI: 10.1016/J.Ejpb.2007.03.024  0.723
2007 Landowski CP, Suzuki Y, Hediger MA. Transporters for excitatory and neutral amino acids Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport. 305-323. DOI: 10.1007/978-0-387-30380-2_15  0.314
2006 Cao X, Gibbs ST, Fang L, Miller HA, Landowski CP, Shin HC, Lennernas H, Zhong Y, Amidon GL, Yu LX, Sun D. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharmaceutical Research. 23: 1675-86. PMID 16841194 DOI: 10.1007/S11095-006-9041-2  0.649
2006 Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL. N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1070-7. PMID 16565170 DOI: 10.1124/Dmd.105.009209  0.645
2006 Landowski CP, Lorenzi PL, Song X, Amidon GL. Nucleoside ester prodrug substrate specificity of liver carboxylesterase. The Journal of Pharmacology and Experimental Therapeutics. 316: 572-80. PMID 16223870 DOI: 10.1124/Jpet.105.092726  0.667
2005 Landowski CP, Song X, Lorenzi PL, Hilfinger JM, Amidon GL. Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism. Pharmaceutical Research. 22: 1510-8. PMID 16132363 DOI: 10.1007/S11095-005-6156-9  0.733
2005 Cao X, Yu LX, Barbaciru C, Landowski CP, Shin HC, Gibbs S, Miller HA, Amidon GL, Sun D. Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability. Molecular Pharmaceutics. 2: 329-40. PMID 16053336 DOI: 10.1021/Mp0499104  0.636
2005 Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 314: 883-90. PMID 15901797 DOI: 10.1124/Jpet.104.082412  0.699
2005 Landowski CP, Vig BS, Song X, Amidon GL. Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs. Molecular Cancer Therapeutics. 4: 659-67. PMID 15827340 DOI: 10.1158/1535-7163.Mct-04-0290  0.648
2005 Song X, Lorenzi PL, Landowski CP, Vig BS, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport. Molecular Pharmaceutics. 2: 157-67. PMID 15804190 DOI: 10.1021/Mp049888E  0.743
2005 Mittal S, Song X, Vig BS, Landowski CP, Kim I, Hilfinger JM, Amidon GL. Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs. Molecular Pharmaceutics. 2: 37-46. PMID 15804176 DOI: 10.1021/Mp049922P  0.73
2004 Faria TN, Timoszyk JK, Stouch TR, Vig BS, Landowski CP, Amidon GL, Weaver CD, Wall DA, Smith RL. A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists. Molecular Pharmaceutics. 1: 67-76. PMID 15832502 DOI: 10.1021/Mp034001K  0.548
2004 Landowski CP, Anderle P, Sun D, Sadee W, Amidon GL. Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies. The Aaps Journal. 6: e21. PMID 15760106 DOI: 10.1208/Aapsj060321  0.621
2003 Landowski CP, Han HK, Lee KD, Amidon GL. A fluorescent hPept1 transporter substrate for uptake screening. Pharmaceutical Research. 20: 1738-45. PMID 14661916 DOI: 10.1023/B:Pham.0000003369.64891.51  0.592
2003 Vig BS, Lorenzi PJ, Mittal S, Landowski CP, Shin HC, Mosberg HI, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis. Pharmaceutical Research. 20: 1381-8. PMID 14567631 DOI: 10.1023/A:1025745824632  0.673
2003 Shin HC, Landowski CP, Sun D, Vig BS, Kim I, Mittal S, Lane M, Rosania G, Drach JC, Amidon GL. Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochemical and Biophysical Research Communications. 307: 696-703. PMID 12893280 DOI: 10.1016/S0006-291X(03)01259-2  0.763
2003 Landowski CP, Sun D, Foster DR, Menon SS, Barnett JL, Welage LS, Ramachandran C, Amidon GL. Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. The Journal of Pharmacology and Experimental Therapeutics. 306: 778-86. PMID 12750437 DOI: 10.1124/Jpet.103.051011  0.75
2002 Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, Amidon GL. Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharmaceutical Research. 19: 1400-16. PMID 12425456 DOI: 10.1023/A:1020483911355  0.672
2001 Sun D, Landowski CP, Chu X, Wallsten R, Komorowski TE, Fleisher D, Amidon GL. Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein. Aaps Pharmsci. 3: E2. PMID 11741253 DOI: 10.1208/Ps030102  0.641
2001 Sun D, Landowski CP, Chu X, Wallsten R, Komorowski TE, Fleisher D, Amidon GL. Drug inhibition of gly-sar uptake and hPep localization using hPepT1-GFP fusion protein Aaps Pharmsci. 3.  0.318
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