☰

Anthony W. Partridge, Ph.D. - Publications

Affiliations: 
2004 University of Toronto, Toronto, ON, Canada 
Area:
Biochemistry
Tree Info Similar researchers PubMed Report error

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kasper SH, Otten S, Squadroni B, Orr-Terry C, Kuang Y, Mussallem L, Ge L, Yan L, Kannan S, Verma CS, Brown CJ, Johannes CW, Lane DP, Chandramohan A, Partridge AW, et al. A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays. Bioengineering & Translational Medicine. 8: e10542. PMID 37693049 DOI: 10.1002/btm2.10542  0.358
2022 Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, Duggal R, Habulihaz B, Barlock B, Ha S, Sadruddin A, Yeo C, Strickland C, Peier A, Henry B, ... ... Partridge AW, et al. Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1. Journal of Medicinal Chemistry. PMID 35853179 DOI: 10.1021/acs.jmedchem.2c00406  0.342
2022 Garrigou M, Sauvagnat B, Duggal R, Boo N, Gopal P, Johnston JM, Partridge A, Sawyer T, Biswas K, Boyer N. Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology. Journal of Medicinal Chemistry. 65: 8961-8974. PMID 35707970 DOI: 10.1021/acs.jmedchem.2c00154  0.408
2022 Li J, Kannan S, Aronica P, Brown CJ, Partridge AW, Verma CS. Molecular descriptors suggest stapling as a strategy for optimizing membrane permeability of cyclic peptides. The Journal of Chemical Physics. 156: 065101. PMID 35168356 DOI: 10.1063/5.0078025  0.396
2022 Sun Y, Lau SY, Lim ZW, Chang SC, Ghadessy F, Partridge A, Miserez A. Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics. Nature Chemistry. 14: 274-283. PMID 35115657 DOI: 10.1038/s41557-021-00854-4  0.335
2021 Lim S, Boyer N, Boo N, Huang C, Venkatachalam G, Angela Juang YC, Garrigou M, Kaan HYK, Duggal R, Peh KM, Sadruddin A, Gopal P, Yuen TY, Ng S, Kannan S, ... ... Partridge AW, et al. Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling. Chemical Science. 12: 15975-15987. PMID 35024121 DOI: 10.1039/d1sc05187c  0.367
2021 Desai TJ, Habulihaz B, Cannon JR, Chandramohan A, Kaan HYK, Sadruddin A, Yuen TY, Johannes C, Thean D, Brown CJ, Lane DP, Partridge AW, Evers R, Sawyer TK, Hochman J. Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides. Pharmaceutical Research. PMID 33821425 DOI: 10.1007/s11095-021-03033-9  0.393
2021 Desai TJ, Habulihaz B, Cannon JR, Chandramohan A, Kaan HYK, Sadruddin A, Yuen TY, Johannes C, Thean D, Brown CJ, Lane DP, Partridge AW, Evers R, Sawyer TK, Hochman J. Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides. Pharmaceutical Research. PMID 33723794 DOI: 10.1007/s11095-021-03005-z  0.391
2021 Peier A, Ge L, Boyer N, Frost J, Duggal R, Biswas K, Edmondson S, Hermes JD, Yan L, Zimprich C, Sadruddin A, Kristal Kaan HY, Chandramohan A, Brown CJ, Thean D, ... ... Partridge AW, et al. NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay. Acs Chemical Biology. PMID 33539064 DOI: 10.1021/acschembio.0c00804  0.429
2020 Ng S, Juang YC, Chandramohan A, Kaan HYK, Sadruddin A, Yuen TY, Ferrer-Gago FJ, Lee XC, Liew X, Johannes CW, Brown CJ, Kannan S, Aronica PG, Berglund NA, Verma CS, ... ... Partridge AW, et al. De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits. Acs Medicinal Chemistry Letters. 11: 1993-2001. PMID 33062184 DOI: 10.1021/Acsmedchemlett.0C00022  0.499
2020 Kannan S, Aronica PGA, Ng S, Gek Lian DT, Frosi Y, Chee S, Shimin J, Yuen TY, Sadruddin A, Kaan HYK, Chandramohan A, Wong JH, Tan YS, Chang ZW, Ferrer-Gago FJ, ... ... Partridge AW, et al. Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability. Chemical Science. 11: 5577-5591. PMID 32874502 DOI: 10.1039/C9Sc06383H  0.5
2020 Lim S, Khoo R, Peh KM, Teo J, Chang SC, Ng S, Beilhartz GL, Melnyk RA, Johannes CW, Brown CJ, Lane DP, Henry B, Partridge AW. bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA). Proceedings of the National Academy of Sciences of the United States of America. PMID 32123106 DOI: 10.1073/Pnas.1920251117  0.618
2020 Kannan S, Aronica PGA, Ng S, Gek Lian DT, Frosi Y, Chee S, Shimin J, Yuen TY, Sadruddin A, Kaan HYK, Chandramohan A, Wong JH, Tan YS, Chang ZW, Ferrer-Gago FJ, ... ... Partridge AW, et al. Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability Chemical Science. 11: 5577-5591. DOI: 10.1039/c9sc06383h  0.368
2019 Diller DJ, Swanson J, Bayden AS, Brown CJ, Thean D, Lane DP, Partridge AW, Sawyer TK, Audie J. Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides. Molecules (Basel, Switzerland). 24. PMID 31847417 DOI: 10.3390/Molecules24244586  0.455
2019 Kannan S, Partridge AW, Lane DP, Verma CS. The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors. International Journal of Molecular Sciences. 20. PMID 31795143 DOI: 10.3390/Ijms20235996  0.405
2019 Yuen TY, Brown CJ, Xue Y, Tan YS, Ferrer Gago FJ, Lee XE, Neo JY, Thean D, Kaan HYK, Partridge AW, Verma CS, Lane DP, Johannes CW. Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles. Chemical Science. 10: 6457-6466. PMID 31316744 DOI: 10.1039/C9Sc01456J  0.425
2019 Partridge AW, Kaan HYK, Juang YC, Sadruddin A, Lim S, Brown CJ, Ng S, Thean D, Ferrer F, Johannes C, Yuen TY, Kannan S, Aronica P, Tan YS, Pradhan MR, et al. Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties. Molecules (Basel, Switzerland). 24. PMID 31226791 DOI: 10.3390/Molecules24122292  0.434
2018 Sawyer TK, Partridge AW, Kaan HYK, Juang YC, Lim S, Johannes C, Yuen TY, Verma C, Kannan S, Aronica P, Tan YS, Sherborne B, Ha S, Hochman J, Chen S, et al. Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges. Bioorganic & Medicinal Chemistry. PMID 29598901 DOI: 10.1016/J.Bmc.2018.03.008  0.436
2012 Lam V, Henault M, Khougaz K, Fortin LJ, Ouellet M, Melnyk R, Partridge A. Resorufin butyrate as a soluble and monomeric high-throughput substrate for a triglyceride lipase. Journal of Biomolecular Screening. 17: 245-51. PMID 21956174 DOI: 10.1177/1087057111422944  0.612
2011 Tam J, Henault M, Li L, Wang Z, Partridge AW, Melnyk RA. An activity-based probe for high-throughput measurements of triacylglycerol lipases. Analytical Biochemistry. 414: 254-60. PMID 21397586 DOI: 10.1016/J.Ab.2011.03.008  0.625
2008 Lau TL, Partridge AW, Ginsberg MH, Ulmer TS. Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry. 47: 4008-16. PMID 18321071 DOI: 10.1021/Bi800107A  0.42
2007 Plotkowski ML, Kim S, Phillips ML, Partridge AW, Deber CM, Bowie JU. Transmembrane domain of myelin protein zero can form dimers: Possible implications for myelin construction Biochemistry. 46: 12164-12173. PMID 17915947 DOI: 10.1021/Bi701066H  0.619
2007 Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID. Structural basis of integrin activation by talin. Cell. 128: 171-82. PMID 17218263 DOI: 10.1016/J.Cell.2006.10.048  0.413
2006 Go MY, Kim S, Partridge AW, Melnyk RA, Rath A, Deber CM, Mogridge J. Self-association of the transmembrane domain of an anthrax toxin receptor. Journal of Molecular Biology. 360: 145-56. PMID 16756998 DOI: 10.1016/J.Jmb.2006.04.072  0.712
2005 Ratnikov BI, Partridge AW, Ginsberg MH. Integrin activation by talin Journal of Thrombosis and Haemostasis. 3: 1783-1790. PMID 16102045 DOI: 10.1111/J.1538-7836.2005.01362.X  0.311
2005 Partridge AW, Liu S, Kim S, Bowie JU, Ginsberg MH. Transmembrane domain helix packing stabilizes integrin αIIbβ3 in the low affinity state Journal of Biological Chemistry. 280: 7294-7300. PMID 15591321 DOI: 10.1074/Jbc.M412701200  0.321
2005 Choi MY, Partridge AW, Daniels C, Du K, Lukacs GL, Deber CM. Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 280: 4968-74. PMID 15537638 DOI: 10.1074/Jbc.M410069200  0.635
2004 Partridge AW, Therien AG, Deber CM. Missense mutations in transmembrane domains of proteins: phenotypic propensity of polar residues for human disease. Proteins. 54: 648-56. PMID 14997561 DOI: 10.1002/Prot.10611  0.647
2003 Melnyk RA, Partridge AW, Yip J, Wu Y, Goto NK, Deber CM. Polar residue tagging of transmembrane peptides. Biopolymers. 71: 675-85. PMID 14991677 DOI: 10.1002/Bip.10595  0.758
2003 Maeda M, Melnyk RA, Partridge AW, Liu LP, Deber CM. Transmembrane segment peptides with double D-amino acid replacements: helicity, hydrophobicity, and antimicrobial activity. Biopolymers. 71: 77-84. PMID 12712502 DOI: 10.1002/Bip.10383  0.726
2003 Partridge AW, Melnyk RA, Yang D, Bowie JU, Deber CM. A transmembrane segment mimic derived from Escherichia coli diacylglycerol kinase inhibits protein activity Journal of Biological Chemistry. 278: 22056-22060. PMID 12686537 DOI: 10.1074/Jbc.M210685200  0.752
2002 Partridge AW, Therien AG, Deber CM. Polar mutations in membrane proteins as a biophysical basis for disease. Biopolymers. 66: 350-8. PMID 12539263 DOI: 10.1002/Bip.10313  0.618
2002 Partridge AW, Melnyk RA, Deber CM. Polar residues in membrane domains of proteins: molecular basis for helix-helix association in a mutant CFTR transmembrane segment. Biochemistry. 41: 3647-53. PMID 11888281 DOI: 10.1021/Bi0120502  0.742
2002 Melnyk RA, Partridge AW, Deber CM. Transmembrane domain mediated self-assembly of major coat protein subunits from Ff bacteriophage. Journal of Molecular Biology. 315: 63-72. PMID 11771966 DOI: 10.1006/Jmbi.2001.5214  0.765
2001 Melnyk RA, Partridge AW, Deber CM. Retention of native-like oligomerization states in transmembrane segment peptides: application to the Escherichia coli aspartate receptor. Biochemistry. 40: 11106-13. PMID 11551208 DOI: 10.1021/bi010642e  0.629
Show low-probability matches.