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K. M. Scaglione, Ph.D. - Publications

Affiliations: 
2007 Saint Louis University, St. Louis, MO, United States 
Area:
Biochemistry, Cell Biology
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19/43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Umano A, Fang K, Qu Z, Scaglione JB, Altinok S, Treadway CJ, Wick ET, Paulakonis E, Karunanayake C, Chou S, Bardakjian TM, Gonzalez-Alegre P, Page RC, Schisler JC, Brown NG, ... ... Scaglione KM, et al. The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP. The Journal of Biological Chemistry. 101899. PMID 35398354 DOI: 10.1016/j.jbc.2022.101899  0.363
2020 Kanack A, Vittal V, Haver H, Keppel T, Gundry RL, Klevit RE, Scaglione KM. UbcH5 interacts with substrates to participate in lysine selection with the E3 ubiquitin ligase CHIP. Biochemistry. PMID 32401531 DOI: 10.1021/Acs.Biochem.0C00084  0.453
2017 Wang B, Zeng L, Merillat SA, Ochaba J, Thompson LM, Barmada SJ, Scaglione KM, Paulson HL. The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin. Neurobiology of Disease. PMID 28986324 DOI: 10.1016/j.nbd.2017.10.002  0.327
2016 Lass A, Cocklin R, Scaglione KM, Skowyra M, Korolev S, Goebl M, Skowyra D. Erratum to: The loop-less (tm)Cdc34 E2 mutant defective polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2. Cell Division. 11: 13. PMID 27761151 DOI: 10.1186/S13008-016-0018-1  0.653
2016 Ristic G, Tsou WL, Guzi E, Kanack AJ, Scaglione KM, Todi SV. USP5 is dispensable for mono-ubiquitin maintenance in Drosophila. The Journal of Biological Chemistry. PMID 26917723 DOI: 10.1074/jbc.M115.703504  0.319
2015 Faggiano S, Menon RP, Kelly GP, Todi SV, Scaglione KM, Konarev PV, Svergun DI, Paulson HL, Pastore A. Allosteric regulation of deubiquitylase activity through ubiquitination. Frontiers in Molecular Biosciences. 2: 2. PMID 25988170 DOI: 10.3389/fmolb.2015.00002  0.389
2015 Vittal V, Shi L, Wenzel DM, Scaglione KM, Duncan ED, Basrur V, Elenitoba-Johnson KS, Baker D, Paulson HL, Brzovic PS, Klevit RE. Intrinsic disorder drives N-terminal ubiquitination by Ube2w. Nature Chemical Biology. 11: 83-9. PMID 25436519 DOI: 10.1038/Nchembio.1700  0.356
2013 Faggiano S, Menon RP, Kelly GP, McCormick J, Todi SV, Scaglione KM, Paulson HL, Pastore A. Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3. Febs Open Bio. 3: 453-8. PMID 24251111 DOI: 10.1016/j.fob.2013.10.005  0.358
2013 Tsou WL, Burr AA, Ouyang M, Blount JR, Scaglione KM, Todi SV. Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. The Journal of Biological Chemistry. 288: 34460-9. PMID 24106274 DOI: 10.1074/jbc.M113.513903  0.398
2013 Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 52: 5354-64. PMID 23865999 DOI: 10.1021/Bi4009209  0.308
2013 Scaglione KM, Basrur V, Ashraf NS, Konen JR, Elenitoba-Johnson KS, Todi SV, Paulson HL. The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. The Journal of Biological Chemistry. 288: 18784-8. PMID 23696636 DOI: 10.1074/jbc.C113.477596  0.345
2011 Scaglione KM, Zavodszky E, Todi SV, Patury S, Xu P, Rodríguez-Lebrón E, Fischer S, Konen J, Djarmati A, Peng J, Gestwicki JE, Paulson HL. Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Molecular Cell. 43: 599-612. PMID 21855799 DOI: 10.1016/J.Molcel.2011.05.036  0.438
2011 Lass A, Cocklin R, Scaglione KM, Skowyra M, Korolev S, Goebl M, Skowyra D. The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2. Cell Division. 6: 7. PMID 21453497 DOI: 10.1186/1747-1028-6-7  0.678
2010 Todi SV, Scaglione KM, Blount JR, Basrur V, Conlon KP, Pastore A, Elenitoba-Johnson K, Paulson HL. Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. The Journal of Biological Chemistry. 285: 39303-13. PMID 20943656 DOI: 10.1074/jbc.M110.181610  0.368
2009 Todi SV, Winborn BJ, Scaglione KM, Blount JR, Travis SM, Paulson HL. Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. The Embo Journal. 28: 372-82. PMID 19153604 DOI: 10.1038/emboj.2008.289  0.338
2008 Winborn BJ, Travis SM, Todi SV, Scaglione KM, Xu P, Williams AJ, Cohen RE, Peng J, Paulson HL. The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. The Journal of Biological Chemistry. 283: 26436-43. PMID 18599482 DOI: 10.1074/Jbc.M803692200  0.364
2007 Scaglione KM, Bansal PK, Deffenbaugh AE, Kiss A, Moore JM, Korolev S, Cocklin R, Goebl M, Kitagawa K, Skowyra D. SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo. Molecular and Cellular Biology. 27: 5860-70. PMID 17562869 DOI: 10.1128/Mcb.01555-06  0.654
2007 Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, Goldberg AL. Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. The Journal of Biological Chemistry. 282: 17375-86. PMID 17426036 DOI: 10.1074/Jbc.M609659200  0.639
2003 Deffenbaugh AE, Scaglione KM, Zhang L, Moore JM, Buranda T, Sklar LA, Skowyra D. Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. Cell. 114: 611-22. PMID 13678584 DOI: 10.1016/S0092-8674(03)00641-X  0.651
Low-probability matches (unlikely to be authored by this person)
2018 Kanack AJ, Newsom OJ, Scaglione KM. Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP. The Journal of Biological Chemistry. PMID 29317501 DOI: 10.1074/jbc.RA117.000477  0.293
2022 Kanack AJ, Olp MD, Newsom OJ, Scaglione JB, Gooden DM, McMahon K, Smith BC, Scaglione K. Chemical regulation of the protein quality control E3 ubiquitin ligase C-terminus of Hsc70 interacting protein (CHIP). Chembiochem : a European Journal of Chemical Biology. PMID 35061295 DOI: 10.1002/cbic.202100633  0.283
2014 Blount JR, Tsou WL, Ristic G, Burr AA, Ouyang M, Galante H, Scaglione KM, Todi SV. Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. Nature Communications. 5: 4638. PMID 25144244 DOI: 10.1038/ncomms5638  0.271
2015 Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC. A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. Structure (London, England : 1993). 23: 472-82. PMID 25684577 DOI: 10.1016/J.Str.2015.01.003  0.247
2024 Williams FN, Travis KL, Haver HN, Umano AD, Guerra-Hernandez Y, Scaglione KM. Acute stress and multicellular development alter the solubility of the Sup35 ortholog ERF3. Microbiology Spectrum. e0160724. PMID 39345220 DOI: 10.1128/spectrum.01607-24  0.188
2023 Haver HN, Wedemeyer M, Butcher E, Peterson FC, Volkman BF, Scaglione KM. Mechanistic Insight into the Suppression of Polyglutamine Aggregation by SRCP1. Acs Chemical Biology. PMID 36791332 DOI: 10.1021/acschembio.2c00893  0.186
2018 Santarriaga S, Haver HN, Kanack AJ, Fikejs AS, Sison SL, Egner JM, Bostrom JR, Seminary ER, Hill RB, Link BA, Ebert AD, Scaglione KM. SRCP1 Conveys Resistance to Polyglutamine Aggregation. Molecular Cell. 71: 216-228.e7. PMID 30029002 DOI: 10.1016/J.Molcel.2018.07.008  0.179
2015 Wang B, Merillat SA, Vincent M, Huber AK, Basrur V, Mangelberger D, Zeng L, Elenitoba-Johnson K, Miller RA, Irani DN, Dlugosz AA, Schnell S, Scaglione KM, Paulson HL. Loss of the Ubiquitin-conjugating Enzyme Ube2W results in susceptibility to early postnatal lethality and defects in skin, immune and male reproductive systems. The Journal of Biological Chemistry. PMID 26601958 DOI: 10.1074/Jbc.M115.676601  0.174
2025 Gutierrez IV, Park M, Sar L, Rodriguez R, Snider DL, Torres G, Scaglione KM, Horner SM. 14-3-3ε UFMylation promotes RIG-I-mediated signaling. Biorxiv : the Preprint Server For Biology. PMID 40166322 DOI: 10.1101/2025.03.19.644084  0.166
2013 Todd PK, Oh SY, Krans A, He F, Sellier C, Frazer M, Renoux AJ, Chen KC, Scaglione KM, Basrur V, Elenitoba-Johnson K, Vonsattel JP, Louis ED, Sutton MA, Taylor JP, et al. CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome. Neuron. 78: 440-55. PMID 23602499 DOI: 10.1016/J.Neuron.2013.03.026  0.164
2021 Luecke IW, Lin G, Santarriaga S, Scaglione KM, Ebert AD. Viral vector gene delivery of the novel chaperone protein SRCP1 to modify insoluble protein in in vitro and in vivo models of ALS. Gene Therapy. PMID 34239068 DOI: 10.1038/s41434-021-00276-4  0.158
2021 Wu Y, Williams FN, Scaglione KM. Assessing the necessity of a family of genes that encode small proteins in development. Micropublication Biology. 2021. PMID 34723153 DOI: 10.17912/micropub.biology.000490  0.153
2019 Madrigal SC, McNeil Z, Sanchez-Hodge R, Shi CH, Patterson C, Scaglione KM, Schisler JC. Changes in protein function underlies the disease spectrum in patients with CHIP mutations. The Journal of Biological Chemistry. PMID 31619515 DOI: 10.1074/jbc.RA119.011173  0.147
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... Scaglione KM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280  0.121
2015 Santarriaga S, Petersen A, Ndukwe K, Brandt A, Gerges N, Bruns Scaglione J, Scaglione KM. The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation. The Journal of Biological Chemistry. 290: 25571-8. PMID 26330554 DOI: 10.1074/Jbc.M115.676247  0.11
2023 Weber JJ, Costa MDC, Scaglione KM, Todi SV, Nguyen HP. Editorial: The role of posttranslational modifications in polyglutamine diseases. Frontiers in Molecular Neuroscience. 16: 1271226. PMID 37654791 DOI: 10.3389/fnmol.2023.1271226  0.1
2019 Santarriaga S, Fikejs A, Scaglione J, Scaglione KM. A Heat Shock Protein 48 (HSP48) Biomolecular Condensate Is Induced during Dictyostelium discoideum Development. Msphere. 4. PMID 31217303 DOI: 10.1128/mSphere.00314-19  0.097
2013 Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of Clinical Investigation. 123: 4158-69. PMID 23999428 DOI: 10.1172/Jci69003  0.093
2021 Haver HN, Scaglione KM. as a Model for Investigating Neurodegenerative Diseases. Frontiers in Cellular Neuroscience. 15: 759532. PMID 34776869 DOI: 10.3389/fncel.2021.759532  0.092
2012 Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. Acs Chemical Biology. 7: 1677-86. PMID 22769591 DOI: 10.1021/Cb3002599  0.084
2022 Williams FN, Scaglione KM. Insights on Microsatellite Characteristics, Evolution, and Function From the Social Amoeba . Frontiers in Neuroscience. 16: 886837. PMID 35769695 DOI: 10.3389/fnins.2022.886837  0.079
2021 Williams FN, Wu Y, Scaglione KM. Development of a Positive Selection High Throughput Genetic Screen in . Frontiers in Cell and Developmental Biology. 9: 725678. PMID 34490273 DOI: 10.3389/fcell.2021.725678  0.06
2022 Loyd V, Scaglione K. Practicing Upstream: Race-Based Trauma Care Training For Veteran's Health Administration Nurse Practitioners. Journal of Doctoral Nursing Practice. 15: 150-156. PMID 36351766 DOI: 10.1891/JDNP-2021-0013  0.017
2021 Scaglione K, Loyd V. A Game Changer: Adult-Geriatric Acute Care Nurse Practitioner Fellowship for the Veterans Health Administration. Journal of Doctoral Nursing Practice. PMID 33468619 DOI: 10.1891/JDNP-D-20-00031  0.011
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