| Year |
Citation |
Score |
| 2025 |
Olp MD, Bursch KL, Wynia-Smith SL, Nuñez R, Goetz CJ, Jackson V, Smith BC. Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains. The Journal of Biological Chemistry. 108289. PMID 39938804 DOI: 10.1016/j.jbc.2025.108289 |
0.303 |
|
| 2024 |
Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC. The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation. Acs Chemical Biology. PMID 39556662 DOI: 10.1021/acschembio.4c00248 |
0.768 |
|
| 2024 |
Bohl K, Wynia-Smith SL, Jones Lipinski RA, Smith BC. Inhibition of Sirtuin Deacylase Activity by Peroxynitrite. Biochemistry. PMID 39256054 DOI: 10.1021/acs.biochem.4c00257 |
0.779 |
|
| 2024 |
Zhang J, Chang J, Chen V, Beg MA, Huang W, Vick L, Wang Y, Zhang H, Yttre E, Gupta A, Castleberry M, Zhang Z, Dai W, Song S, Zhu J, ... ... Smith BC, et al. Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway. Biorxiv : the Preprint Server For Biology. PMID 39071358 DOI: 10.1101/2023.09.07.556574 |
0.702 |
|
| 2024 |
Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC. Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 38618911 DOI: 10.1152/ajpregu.00259.2023 |
0.749 |
|
| 2024 |
Bursch KL, Goetz CJ, Smith BC. Current Trends in Sirtuin Activator and Inhibitor Development. Molecules (Basel, Switzerland). 29. PMID 38474697 DOI: 10.3390/molecules29051185 |
0.792 |
|
| 2024 |
Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC. Cancer-associated Polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression. The Journal of Biological Chemistry. 107146. PMID 38460939 DOI: 10.1016/j.jbc.2024.107146 |
0.754 |
|
| 2023 |
Kerber PJ, Nuñez R, Jensen DR, Zhou AL, Peterson FC, Hill RB, Volkman BF, Smith BC. Fragment-based screening by protein-detected NMR spectroscopy. Methods in Enzymology. 690: 285-310. PMID 37858532 DOI: 10.1016/bs.mie.2023.06.018 |
0.788 |
|
| 2023 |
Bursch KL, Olp MD, Smith BC. Analysis of continuous enzyme kinetic data using ICEKAT. Methods in Enzymology. 690: 109-129. PMID 37858527 DOI: 10.1016/bs.mie.2023.06.019 |
0.756 |
|
| 2023 |
Ordonez-Rubiano SC, Maschinot CA, Wang S, Sood S, Baracaldo-Lancheros LF, Strohmier BP, McQuade AJ, Smith BC, Dykhuizen EC. Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer. Journal of Medicinal Chemistry. 66: 11250-11270. PMID 37552884 DOI: 10.1021/acs.jmedchem.3c00671 |
0.317 |
|
| 2023 |
Yang M, Smith BC. Cysteine and methionine oxidation in thrombotic disorders. Current Opinion in Chemical Biology. 76: 102350. PMID 37331217 DOI: 10.1016/j.cbpa.2023.102350 |
0.704 |
|
| 2023 |
Yang M, Chiu J, Scartelli C, Ponzar N, Patel S, Patel A, Ferreira RB, Keyes RF, Carroll K, Pozzi N, Hogg PJ, Smith BC, Flaumenhaft R. Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation. Journal of Thrombosis and Haemostasis : Jth. PMID 37037379 DOI: 10.1016/j.jtha.2023.03.034 |
0.764 |
|
| 2022 |
AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB. Fluorinated triphenylphosphonium analogs improve cell selectivity and detection of mito-metformin. Iscience. 25: 105670. PMID 36567718 DOI: 10.1016/j.isci.2022.105670 |
0.703 |
|
| 2022 |
Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. Journal of Medicinal Chemistry. PMID 36227159 DOI: 10.1021/acs.jmedchem.2c00864 |
0.749 |
|
| 2022 |
Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC. terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells. Frontiers in Endocrinology. 13: 923925. PMID 36176467 DOI: 10.3389/fendo.2022.923925 |
0.792 |
|
| 2022 |
Fisher CL, Fallot LB, Wan TC, Keyes RF, Suresh RR, Rothwell AC, Gao ZG, McCorvy JD, Smith BC, Jacobson KA, Auchampach JA. Characterization of Dual-Acting A Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gα and Gα Isoprotein Activation. Acs Pharmacology & Translational Science. 5: 625-641. PMID 35983277 DOI: 10.1021/acsptsci.2c00076 |
0.624 |
|
| 2022 |
Johnston N, Samuels TL, Goetz CJ, Arnold LA, Smith BC, Seabloom D, Wuertz B, Ondrey F, Wiedmann TS, Vuksanovic N, Silvaggi NR, MacKinnon AC, Miller J, Bock J, Blumin JH. Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damaged in a Laryngopharyngeal Reflux Mouse Model. The Laryngoscope. PMID 35678265 DOI: 10.1002/lary.30242 |
0.725 |
|
| 2022 |
Kanack AJ, Olp MD, Newsom OJ, Scaglione JB, Gooden DM, McMahon K, Smith BC, Scaglione K. Chemical regulation of the protein quality control E3 ubiquitin ligase C-terminus of Hsc70 interacting protein (CHIP). Chembiochem : a European Journal of Chemical Biology. PMID 35061295 DOI: 10.1002/cbic.202100633 |
0.804 |
|
| 2021 |
Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC. Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. Acs Medicinal Chemistry Letters. 12: 1773-1782. PMID 34795867 DOI: 10.1021/acsmedchemlett.1c00388 |
0.718 |
|
| 2020 |
Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC. Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia. Blood Advances. 4: 4494-4507. PMID 32946569 DOI: 10.1182/Bloodadvances.2020001609 |
0.774 |
|
| 2020 |
Goetz CJ, Sprague DJ, Smith BC. Development of activity-based probes for the protein deacylase Sirt1. Bioorganic Chemistry. 104: 104232. PMID 32911193 DOI: 10.1016/J.Bioorg.2020.104232 |
0.808 |
|
| 2020 |
Olp MD, Kalous KS, Smith BC. ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces. Bmc Bioinformatics. 21: 186. PMID 32410570 DOI: 10.1186/S12859-020-3513-Y |
0.775 |
|
| 2020 |
Kalous KS, Wynia-Smith SL, Summers SB, Smith BC. Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants. The Journal of Biological Chemistry. PMID 32371394 DOI: 10.1074/Jbc.Ra119.011988 |
0.387 |
|
| 2020 |
Kapoor A, Ghosh AK, Forman M, Hu X, Ye W, Southall N, Marugan JJ, Keyes RF, Smith BC, Meyers DJ, Ferrer M, Arav-Boger R. Validation and characterization of five distinct novel inhibitors of human cytomegalovirus. Journal of Medicinal Chemistry. PMID 32191456 DOI: 10.1021/Acs.Jmedchem.9B01501 |
0.312 |
|
| 2020 |
Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. Covalent-fragment screening of BRD4 identifies a ligandable site orthogonal to the acetyl-lysine binding sites. Acs Chemical Biology. PMID 32149490 DOI: 10.1021/Acschembio.0C00058 |
0.777 |
|
| 2020 |
Lipinski RAJ, Wynia-Smith S, Nord J, Smith BC. 2131-P: BET Bromodomain Inhibition Upregulates SIRT1 In Pancreatic ß-Cells Diabetes. 69. DOI: 10.2337/Db20-2131-P |
0.393 |
|
| 2020 |
Nord J, Wynia-Smith S, Smith BC. 2117-P: BET Bromodomain Inhibitors Mitigate Cytokine-Induced Transcription in ß-Cells via Inhibition of Nf-κB Diabetes. 69. DOI: 10.2337/Db20-2117-P |
0.317 |
|
| 2020 |
Johnson CK, Snyder AA, Gambill AK, Arnett DC, Smith BC. Conformational States of Nitric Oxide Synthase Characterized by Time-Resolved Fluorescence Biophysical Journal. 118: 455a. DOI: 10.1016/J.Bpj.2019.11.2534 |
0.626 |
|
| 2019 |
McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD. Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni. Plos Neglected Tropical Diseases. 13: e0007826. PMID 31730614 DOI: 10.1371/Journal.Pntd.0007826 |
0.775 |
|
| 2019 |
Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding PJ, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, et al. Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. Circulation Research. PMID 31625810 DOI: 10.1161/Circresaha.119.315833 |
0.763 |
|
| 2019 |
Yang M, Harberg C, Chen W, Wynia-Smith SL, Carroll KS, Zielonka J, Silverstein RL, Smith BC. Protein Cysteine Sulfenylation By CD36-Dependent Reactive Oxygen Species Signaling Promotes Platelet Activation Blood. 134: 2338-2338. DOI: 10.1182/Blood-2019-122465 |
0.555 |
|
| 2018 |
Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA. Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes. The Journal of Biological Chemistry. PMID 29483187 DOI: 10.1074/Jbc.M117.817700 |
0.589 |
|
| 2018 |
Hanson QM, Carley JR, Gilbreath TJ, Smith BC, Underbakke ES. Calmodulin-induced conformational control and allostery underlying neuronal nitric oxide synthase activation. Journal of Molecular Biology. PMID 29458127 DOI: 10.1016/J.Jmb.2018.02.003 |
0.752 |
|
| 2018 |
Fahey JM, Stancill JS, Smith BC, Girotti AW. Antagonistic effects of nitric oxide in a glioblastoma photodynamic therapy model:mitigation by BET bromodomain inhibitor JQ1. The Journal of Biological Chemistry. PMID 29440272 DOI: 10.1074/Jbc.Ra117.000443 |
0.372 |
|
| 2018 |
Kalous K, Wynia-Smith S, Olp M, Smith B. Regulation of human sirtuin deacylase activity by cellular oxidants Free Radical Biology and Medicine. 128: S138. DOI: 10.1016/J.Freeradbiomed.2018.10.364 |
0.437 |
|
| 2018 |
Yang M, Harberg C, Wynia-Smith S, Ferreira R, Zielonka J, Carroll K, Silverstein R, Smith B. Protein sulfenylation by oxidized lipid signaling promotes activation of platelets Free Radical Biology and Medicine. 128: S44-S45. DOI: 10.1016/J.Freeradbiomed.2018.10.071 |
0.563 |
|
| 2018 |
Johnson CK, Arnett DC, Smith BC. Conformations and Single-Molecule Dynamics of Nitric Oxide Synthase Biophysical Journal. 114: 684a. DOI: 10.1016/J.Bpj.2017.11.3690 |
0.625 |
|
| 2017 |
Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB. Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR. Chembiochem : a European Journal of Chemical Biology. PMID 29239081 DOI: 10.1002/Cbic.201700386 |
0.793 |
|
| 2017 |
Olp M, Zhu N, Smith B. Metabolically-derived lysine acylations and neighboring modifications tune BET bromodomain binding to histone H4. Biochemistry. PMID 28945351 DOI: 10.1021/Acs.Biochem.7B00595 |
0.813 |
|
| 2017 |
Johnson CK, Arnett DC, Persechini A, Smith BC. Conformational Control of Nitric Oxide Synthase Activity: Results from Time-Resolved and Single-Molecule Fluorescence Biophysical Journal. 112: 202a-203a. DOI: 10.1016/J.Bpj.2016.11.1120 |
0.663 |
|
| 2016 |
Kalous KS, Wynia-Smith SL, Olp MD, Smith BC. Mechanism of Sirt1 NAD+-dependent Deacetylase Inhibition by Cysteine S-nitrosation. The Journal of Biological Chemistry. PMID 27756843 DOI: 10.1074/Jbc.M116.754655 |
0.809 |
|
| 2016 |
Wynia-Smith SL, Smith BC. Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases. Nitric Oxide : Biology and Chemistry. PMID 27720836 DOI: 10.1016/J.Niox.2016.10.001 |
0.355 |
|
| 2016 |
Zhou Y, Wynia-Smith SL, Couvertier SM, Kalous KS, Marletta MA, Smith BC, Weerapana E. Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S-Nitrosation Sites on Cathepsin D and HADH2. Cell Chemical Biology. PMID 27291402 DOI: 10.1016/J.Chembiol.2016.05.008 |
0.598 |
|
| 2015 |
Rao M, Smith BC, Marletta MA. Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. Mbio. 6: e00206-15. PMID 25944856 DOI: 10.1128/Mbio.00206-15 |
0.557 |
|
| 2015 |
Shteyer E, Edvardson S, Wynia-Smith SL, Pierri CL, Zangen T, Hashavya S, Begin M, Yaacov B, Cinamon Y, Koplewitz BZ, Vromen A, Elpeleg O, Smith BC. Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia. Gastroenterology. 148: 533-536.e4. PMID 25479138 DOI: 10.1053/J.Gastro.2014.11.044 |
0.318 |
|
| 2014 |
Campbell MG, Smith BC, Potter CS, Carragher B, Marletta MA. Molecular architecture of mammalian nitric oxide synthases. Proceedings of the National Academy of Sciences of the United States of America. 111: E3614-23. PMID 25125509 DOI: 10.1073/Pnas.1413763111 |
0.533 |
|
| 2013 |
Smith BC, Underbakke ES, Kulp DW, Schief WR, Marletta MA. Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. Proceedings of the National Academy of Sciences of the United States of America. 110: E3577-86. PMID 24003111 DOI: 10.1073/Pnas.1313331110 |
0.78 |
|
| 2012 |
Smith BC, Marletta MA. Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. Current Opinion in Chemical Biology. 16: 498-506. PMID 23127359 DOI: 10.1016/J.Cbpa.2012.10.016 |
0.55 |
|
| 2012 |
Smith BC, Fernhoff NB, Marletta MA. Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. Biochemistry. 51: 1028-40. PMID 22242685 DOI: 10.1021/Bi201818C |
0.784 |
|
| 2012 |
Smith BC, Anderson MA, Hoadley KA, Keck JL, Cleland WW, Denu JM. Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae. Biochemistry. 51: 243-56. PMID 22229411 DOI: 10.1021/Bi2015508 |
0.573 |
|
| 2011 |
Kasamatsu A, Nakao M, Smith BC, Comstock LR, Ono T, Kato J, Denu JM, Moss J. Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3. The Journal of Biological Chemistry. 286: 21110-7. PMID 21498885 DOI: 10.1074/Jbc.M111.237636 |
0.551 |
|
| 2011 |
Hallows WC, Yu W, Smith BC, Devries MK, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell. 41: 139-49. PMID 21255725 DOI: 10.1016/J.Molcel.2011.01.002 |
0.794 |
|
| 2011 |
Smith BC, Settles B, Hallows WC, Craven MW, Denu JM. SIRT3 substrate specificity determined by peptide arrays and machine learning. Acs Chemical Biology. 6: 146-57. PMID 20945913 DOI: 10.1021/Cb100218D |
0.804 |
|
| 2009 |
Smith BC, Hallows WC, Denu JM. A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. Analytical Biochemistry. 394: 101-9. PMID 19615966 DOI: 10.1016/J.Ab.2009.07.019 |
0.795 |
|
| 2009 |
Hallows WC, Smith BC, Lee S, Denu JM. Ure(k)a! Sirtuins Regulate Mitochondria. Cell. 137: 404-6. PMID 19410538 DOI: 10.1016/J.Cell.2009.04.036 |
0.78 |
|
| 2009 |
Smith BC, Denu JM. Chemical mechanisms of histone lysine and arginine modifications. Biochimica Et Biophysica Acta. 1789: 45-57. PMID 18603028 DOI: 10.1016/J.Bbagrm.2008.06.005 |
0.621 |
|
| 2008 |
Smith BC, Hallows WC, Denu JM. Mechanisms and molecular probes of sirtuins. Chemistry & Biology. 15: 1002-13. PMID 18940661 DOI: 10.1016/J.Chembiol.2008.09.009 |
0.788 |
|
| 2007 |
Smith BC, Denu JM. Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide. Biochemistry. 46: 14478-86. PMID 18027980 DOI: 10.1021/Bi7013294 |
0.595 |
|
| 2007 |
Smith BC, Denu JM. Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases. The Journal of Biological Chemistry. 282: 37256-65. PMID 17951578 DOI: 10.1074/Jbc.M707878200 |
0.605 |
|
| 2007 |
Garske AL, Smith BC, Denu JM. Linking SIRT2 to Parkinson's disease. Acs Chemical Biology. 2: 529-32. PMID 17708669 DOI: 10.1021/Cb700160D |
0.785 |
|
| 2007 |
Smith BC, Denu JM. Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage. Journal of the American Chemical Society. 129: 5802-3. PMID 17439123 DOI: 10.1021/Ja070162W |
0.602 |
|
| 2006 |
Smith BC, Denu JM. Sirtuins caught in the act. Structure (London, England : 1993). 14: 1207-8. PMID 16905094 DOI: 10.1016/J.Str.2006.07.004 |
0.557 |
|
| 2006 |
Smith BC, Denu JM. Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine. Biochemistry. 45: 272-82. PMID 16388603 DOI: 10.1021/Bi052014T |
0.565 |
|
| 2005 |
Grubisha O, Smith BC, Denu JM. Small molecule regulation of Sir2 protein deacetylases. The Febs Journal. 272: 4607-16. PMID 16156783 DOI: 10.1111/J.1742-4658.2005.04862.X |
0.62 |
|
| 2005 |
Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. The Journal of Biological Chemistry. 280: 17187-95. PMID 15749705 DOI: 10.1074/Jbc.M501250200 |
0.799 |
|
| 2004 |
Schmidt MT, Smith BC, Jackson MD, Denu JM. Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation. The Journal of Biological Chemistry. 279: 40122-9. PMID 15269219 DOI: 10.1074/Jbc.M407484200 |
0.651 |
|
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