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Robert R. Knowles - Publications

Affiliations: 
Chemistry Princeton University, Princeton, NJ 
Area:
selective catalysis
Website:
http://chemists.princeton.edu/knowles/
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Pinto Pereira Junior MV, Geunes EP, Shao H, Zhang Y, Cheng J, Magpantay SV, Mercado BQ, Mayer JM, Houk KN, Knowles RR, Miller SJ. Enantioselective Hydrodifluoroalkylation of Alkenes with Conformationally Tuned Peptidyl Hydrogen Atom Transfer Catalysts. Journal of the American Chemical Society. PMID 40111502 DOI: 10.1021/jacs.5c01166  0.55
2025 Seliger J, Fries LR, Meinhardt JM, Knowles RR. Photoredox-Catalyzed Nucleophilic Aromatic Substitution of Halophenols with Azoles via Oligomeric Phenylene Oxide Radicals. Journal of the American Chemical Society. 147: 9931-9938. PMID 40048652 DOI: 10.1021/jacs.5c01012  0.379
2025 Keen B, Cong C, Castanedo A, Davies GHM, Knowles RR, Davies HML. Stereoselective Synthesis of Highly Functionalized Bicyclo[2.1.0]pentanes by Sequential [2 + 1] and [2 + 2] Cycloadditions. Organic Letters. PMID 39928956 DOI: 10.1021/acs.orglett.5c00054  0.326
2024 Lin A, Karrasch MJ, Yan Q, Ganley JM, Hejna BG, Knowles RR. Intermolecular Anti-Markovnikov Hydroamination of Alkenes with Sulfonamides, Sulfamides, and Sulfamates. Acs Catalysis. 14: 13098-13104. PMID 39926160 DOI: 10.1021/acscatal.4c03960  0.449
2024 Sedillo K, Fan F, Knowles RR, Doyle AG. Cooperative Phosphine-Photoredox Catalysis Enables N-H Activation of Azoles for Intermolecular Olefin Hydroamination. Journal of the American Chemical Society. PMID 38985548 DOI: 10.1021/jacs.4c05881  0.585
2024 Lin A, Lee S, Knowles RR. Organic Synthesis Away from Equilibrium: Contrathermodynamic Transformations Enabled by Excited-State Electron Transfer. Accounts of Chemical Research. PMID 38905487 DOI: 10.1021/acs.accounts.4c00227  0.429
2024 Rodgers LVH, Nguyen ST, Cox JH, Zervas K, Yuan Z, Sangtawesin S, Stacey A, Jaye C, Weiland C, Pershin A, Gali A, Thomsen L, Meynell SA, Hughes LB, Jayich ACB, ... ... Knowles RR, et al. Diamond surface functionalization via visible light-driven C-H activation for nanoscale quantum sensing. Proceedings of the National Academy of Sciences of the United States of America. 121: e2316032121. PMID 38451945 DOI: 10.1073/pnas.2316032121  0.563
2023 Geunes EP, Meinhardt JM, Wu EJ, Knowles RR. Photocatalytic Anti-Markovnikov Hydroamination of Alkenes with Primary Heteroaryl Amines. Journal of the American Chemical Society. 145: 21738-21744. PMID 37787499 DOI: 10.1021/jacs.3c08428  0.41
2023 Hejna BG, Ganley JM, Shao H, Tian H, Ellefsen JD, Fastuca NJ, Houk KN, Miller SJ, Knowles RR. Catalytic Asymmetric Hydrogen Atom Transfer: Enantioselective Hydroamination of Alkenes. Journal of the American Chemical Society. PMID 37432783 DOI: 10.1021/jacs.3c04591  0.564
2023 Qiu G, Ni CL, Knowles RR. Isotopic Fractionation as a Mechanistic Probe in Light-Driven C-H Bond Exchange Reactions. Journal of the American Chemical Society. 145: 11537-11543. PMID 37192535 DOI: 10.1021/jacs.2c11212  0.341
2023 Nguyen ST, Fries LR, Cox JH, Ma Y, Fors BP, Knowles RR. Chemical Recycling of Thiol Epoxy Thermosets via Light-Driven C-C Bond Cleavage. Journal of the American Chemical Society. PMID 37167410 DOI: 10.1021/jacs.3c00958  0.628
2022 Shin NY, Tsui E, Reinhold A, Scholes GD, Bird MJ, Knowles RR. Radicals as Exceptional Electron-Withdrawing Groups: Nucleophilic Aromatic Substitution of Halophenols Via Homolysis-Enabled Electronic Activation. Journal of the American Chemical Society. 144: 21783-21790. PMID 36395367 DOI: 10.1021/jacs.2c10296  0.345
2022 Murray PRD, Leibler IN, Hell SM, Villalona E, Doyle AG, Knowles RR. Radical Redox Annulations: A General Light-Driven Method for the Synthesis of Saturated Heterocycles. Acs Catalysis. 12: 13732-13740. PMID 36366762 DOI: 10.1021/acscatal.2c04316  0.622
2022 Xu EY, Werth J, Roos CB, Bendelsmith AJ, Sigman MS, Knowles RR. Noncovalent Stabilization of Radical Intermediates in the Enantioselective Hydroamination of Alkenes with Sulfonamides. Journal of the American Chemical Society. PMID 36197450 DOI: 10.1021/jacs.2c07099  0.596
2021 Zhao K, Knowles RR. Contra-Thermodynamic Positional Isomerization of Olefins. Journal of the American Chemical Society. PMID 34968043 DOI: 10.1021/jacs.1c11681  0.333
2021 Murray PRD, Cox JH, Chiappini ND, Roos CB, McLoughlin EA, Hejna BG, Nguyen ST, Ripberger HH, Ganley JM, Tsui E, Shin NY, Koronkiewicz B, Qiu G, Knowles RR. Photochemical and Electrochemical Applications of Proton-Coupled Electron Transfer in Organic Synthesis. Chemical Reviews. PMID 34813277 DOI: 10.1021/acs.chemrev.1c00374  0.664
2021 Nguyen ST, McLoughlin EA, Cox JH, Fors BP, Knowles RR. Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage. Journal of the American Chemical Society. PMID 34333967 DOI: 10.1021/jacs.1c05330  0.617
2021 Qin Y, Zhu Q, Sun R, Ganley JM, Knowles RR, Nocera DG. Mechanistic Investigation and Optimization of Photoredox Anti-Markovnikov Hydroamination. Journal of the American Chemical Society. PMID 34191486 DOI: 10.1021/jacs.1c03644  0.333
2021 Qin Y, Zhu Q, Sun R, Ganley JM, Knowles RR, Nocera DG. Mechanistic Investigation and Optimization of Photoredox Anti-Markovnikov Hydroamination. Journal of the American Chemical Society. PMID 34191486 DOI: 10.1021/jacs.1c03644  0.333
2021 Zhao K, Seidler G, Knowles RR. 1,3-Alkyl Transposition in Allylic Alcohols Enabled by Proton-Coupled Electron Transfer. Angewandte Chemie (International Ed. in English). PMID 34159700 DOI: 10.1002/anie.202105285  0.388
2021 Zhao K, Seidler G, Knowles RR. 1,3-Alkyl Transposition in Allylic Alcohols Enabled by Proton-Coupled Electron Transfer. Angewandte Chemie (International Ed. in English). PMID 34159700 DOI: 10.1002/anie.202105285  0.388
2021 Murray PRD, Bussink WMM, Davies GHM, van der Mei FW, Antropow AH, Edwards JT, D'Agostino LA, Ellis JM, Hamann LG, Romanov-Michailidis F, Knowles RR. Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes. Journal of the American Chemical Society. PMID 33666086 DOI: 10.1021/jacs.1c01173  0.322
2020 Tsui E, Wang H, Knowles RR. Catalytic generation of alkoxy radicals from unfunctionalized alcohols. Chemical Science. 11: 11124-11141. PMID 33384861 DOI: 10.1039/D0Sc04542J  0.424
2020 Ganley JM, Murray PRD, Knowles RR. Photocatalytic Generation of Aminium Radical Cations for C─N Bond Formation. Acs Catalysis. 10: 11712-11738. PMID 33163257 DOI: 10.1021/Acscatal.0C03567  0.484
2020 Tsui E, Metrano AJ, Tsuchiya Y, Knowles RR. Catalytic Hydroetherification of Unactivated Alkenes Enabled by Proton-Coupled Electron Transfer. Angewandte Chemie (International Ed. in English). PMID 32227658 DOI: 10.1002/Anie.202003959  0.792
2020 Roos CB, Demaerel J, Graff DE, Knowles RR. Enantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer. Journal of the American Chemical Society. PMID 32182054 DOI: 10.1021/Jacs.0C01332  0.542
2019 Nguyen ST, Zhu Q, Knowles RR. PCET-Enabled Olefin Hydroamidation Reactions with -Alkyl Amides. Acs Catalysis. 9: 4502-4507. PMID 32292642 DOI: 10.1021/Acscatal.9B00966  0.53
2019 Shin NY, Ryss JM, Zhang X, Miller SJ, Knowles RR. Lightdriven deracemization enabled by excitedstate electron transfer. Science (New York, N.Y.). 366: 364-369. PMID 31624212 DOI: 10.1126/Science.Aay2204  0.626
2019 Miller DC, Ganley JM, Musacchio AJ, Sherwood TC, Ewing WR, Knowles RR. Anti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines. Journal of the American Chemical Society. PMID 31603324 DOI: 10.1021/Jacs.9B08746  0.469
2019 Qiu G, Knowles RR. Understanding Chemoselectivity in Proton-Coupled Electron Transfer: A Kinetic Study of Amide and Thiol Activation. Journal of the American Chemical Society. PMID 31573194 DOI: 10.1021/Jacs.9B08398  0.507
2019 Morton CM, Zhu Q, Ripberger H, Troian-Gautier L, Toa ZSD, Knowles RR, Alexanian EJ. C-H Alkylation via Multisite-Proton-Coupled Electron Transfer of an Aliphatic C-H Bond. Journal of the American Chemical Society. PMID 31356059 DOI: 10.1021/Jacs.9B06834  0.461
2019 Zhao K, Yamashita K, Carpenter J, Sherwood TC, Ewing WR, Cheng PTW, Knowles RR. Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer. Journal of the American Chemical Society. PMID 31117664 DOI: 10.1021/Jacs.9B03973  0.626
2019 Loose F, Wang D, Tian L, Scholes GD, Knowles RR, Chirik PJ. Evaluation of excited state bond weakening for ammonia synthesis from a manganese nitride: stepwise proton coupled electron transfer is preferred over hydrogen atom transfer. Chemical Communications (Cambridge, England). PMID 31025662 DOI: 10.1039/C9Cc01046G  0.691
2019 Sherwood TC, Xiao HY, Bhaskar RG, Simmons EM, Zaretsky S, Rauch MP, Knowles RR, Dhar TGM. Decarboxylative intramolecular arene alkylation using N-(acyloxy)phthalimides, an organic photocatalyst, and visible light. The Journal of Organic Chemistry. PMID 30905152 DOI: 10.1021/Acs.Joc.9B00432  0.428
2019 Wang D, Loose F, Chirik PJ, Knowles RR. N-H Bond Formation in a Manganese(V) Nitride Yields Ammonia by Light-Driven Proton-Coupled Electron Transfer. Journal of the American Chemical Society. PMID 30803234 DOI: 10.1021/Jacs.8B12957  0.702
2019 Qiu G, Knowles RR. Rate-Driving Force Relationships in the Multisite-PCET Activation of Ketones. Journal of the American Chemical Society. PMID 30665301 DOI: 10.1021/Jacs.8B13451  0.413
2019 Ota E, Wang H, Frye NL, Knowles RR. A Redox Strategy for Light-Driven, Out-of-Equilibrium Isomerizations and Application to Catalytic C-C Bond Cleavage Reactions. Journal of the American Chemical Society. PMID 30628777 DOI: 10.1021/Jacs.8B12552  0.498
2019 Nguyen ST, Murray PRD, Knowles RR. Light-Driven Depolymerization of Native Lignin Enabled by Proton-Coupled Electron Transfer Acs Catalysis. 10: 800-805. DOI: 10.1021/Acscatal.9B04813  0.458
2018 Gentry EC, Rono LJ, Hale ME, Matsuura R, Knowles RR. Enantioselective Synthesis of Pyrroloindolines via Non-Covalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products. Journal of the American Chemical Society. PMID 29432006 DOI: 10.1021/Jacs.7B13616  0.779
2017 Zhu Q, Graff DE, Knowles RR. Intermolecular Anti-Markovnikov Hydroamination of Unactivated Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer. Journal of the American Chemical Society. PMID 29268020 DOI: 10.1021/Jacs.7B11144  0.506
2017 Musacchio AJ, Lainhart BC, Zhang X, Naguib SG, Sherwood TC, Knowles RR. Catalytic intermolecular hydroaminations of unactivated olefins with secondary alkyl amines. Science (New York, N.Y.). 355: 727-730. PMID 28209894 DOI: 10.1126/Science.Aal3010  0.542
2016 Yayla HG, Peng F, Mangion IK, McLaughlin M, Campeau LC, Davies IW, DiRocco DA, Knowles RR. Discovery and mechanistic study of a photocatalytic indoline dehydrogenation for the synthesis of elbasvir. Chemical Science. 7: 2066-2073. PMID 29899932 DOI: 10.1039/C5Sc03350K  0.392
2016 Choi GJ, Zhu Q, Miller DC, Gu CJ, Knowles RR. Catalytic alkylation of remote C-H bonds enabled by proton-coupled electron transfer. Nature. PMID 27732585 DOI: 10.1038/Nature19811  0.522
2016 Miller DC, Tarantino KT, Knowles RR. Proton-Coupled Electron Transfer in Organic Synthesis: Fundamentals, Applications, and Opportunities. Topics in Current Chemistry (Journal). 374: 30. PMID 27573270 DOI: 10.1007/S41061-016-0030-6  0.462
2016 Yayla HG, Wang H, Tarantino KT, Orbe HS, Knowles RR. Catalytic Ring-Opening of Cyclic Alcohols Enabled by PCET Activation of Strong O-H Bonds. Journal of the American Chemical Society. PMID 27515494 DOI: 10.1021/Jacs.6B06517  0.486
2016 Gentry EC, Knowles RR. Synthetic Applications of Proton-Coupled Electron Transfer. Accounts of Chemical Research. PMID 27472068 DOI: 10.1021/Acs.Accounts.6B00272  0.786
2016 Zhu Q, Gentry EC, Knowles RR. Catalytic Carbocation Generation Enabled by the Mesolytic Cleavage of Alkoxyamine Radical Cations. Angewandte Chemie (International Ed. in English). PMID 27403637 DOI: 10.1002/Anie.201604619  0.762
2016 Nguyen LQ, Knowles RR. Catalytic C-N Bond-Forming Reactions Enabled by Proton-Coupled Electron Transfer Activation of Amide N-H Bonds Acs Catalysis. 6: 2894-2903. DOI: 10.1021/Acscatal.6B00486  0.511
2016 Nguyen LQ, Knowles RR. ChemInform Abstract: Catalytic C-N Bond-Forming Reactions Enabled by Proton-Coupled Electron Transfer Activation of Amide N-H Bonds Cheminform. 47. DOI: 10.1002/chin.201626249  0.364
2015 Knowles RR. Reaching Your Full (Over)Potential: A Novel Approach to Electrocatalytic Oxygen Reduction. Acs Central Science. 1: 224-5. PMID 27162976 DOI: 10.1021/Acscentsci.5B00257  0.3
2015 Miller DC, Choi GJ, Orbe HS, Knowles RR. Catalytic Olefin Hydroamidation Enabled by Proton-Coupled Electron Transfer. Journal of the American Chemical Society. PMID 26439818 DOI: 10.1021/Jacs.5B09671  0.37
2015 Choi GJ, Knowles RR. Catalytic Alkene Carboaminations Enabled by Oxidative Proton-Coupled Electron Transfer. Journal of the American Chemical Society. 137: 9226-9. PMID 26166022 DOI: 10.1021/Jacs.5B05377  0.514
2015 Tarantino KT, Miller DC, Callon TA, Knowles RR. Bond-weakening catalysis: conjugate aminations enabled by the soft homolysis of strong N-H bonds. Journal of the American Chemical Society. 137: 6440-3. PMID 25945955 DOI: 10.1021/Jacs.5B03428  0.456
2014 Musacchio AJ, Nguyen LQ, Beard GH, Knowles RR. Catalytic olefin hydroamination with aminium radical cations: a photoredox method for direct C-N bond formation. Journal of the American Chemical Society. 136: 12217-20. PMID 25127420 DOI: 10.1021/Ja5056774  0.534
2014 Yayla HG, Knowles RR. Proton-coupled electron transfer in organic synthesis: Novel homolytic bond activations and catalytic asymmetric reactions with free radicals Synlett. 25. DOI: 10.1055/S-0034-1379304  0.539
2014 List B, Gemmeren Mv, Rono LJ, Yayla HG, Wang DY, Armstrong MF, Knowles RR. Asymmetric Counteranion-Directed Photoredox Catalysis Synfacts. 10: 209-209. DOI: 10.1055/S-0033-1340657  0.357
2013 Rono LJ, Yayla HG, Wang DY, Armstrong MF, Knowles RR. Enantioselective photoredox catalysis enabled by proton-coupled electron transfer: development of an asymmetric aza-pinacol cyclization. Journal of the American Chemical Society. 135: 17735-8. PMID 24215561 DOI: 10.1021/Ja4100595  0.624
2013 Tarantino KT, Liu P, Knowles RR. Catalytic ketyl-olefin cyclizations enabled by proton-coupled electron transfer. Journal of the American Chemical Society. 135: 10022-5. PMID 23796403 DOI: 10.1021/Ja404342J  0.488
2011 Knowles RR, Carpenter J, Blakey SB, Kayano A, Mangion IK, Sinz CJ, Macmillan DW. Total synthesis of diazonamide A. Chemical Science (Royal Society of Chemistry : 2010). 2011: 308-311. PMID 22860227 DOI: 10.1039/C0Sc00577K  0.755
2011 Knowles RR, Carpenter J, Blakey SB, Kayano A, Mangion IK, Sinz CJ, MacMillan DWC. Synthesis of Diazonamide A Synfacts. 2011: 465-465. DOI: 10.1055/S-0030-1259792  0.664
2010 Knowles RR, Jacobsen EN. Attractive noncovalent interactions in asymmetric catalysis: links between enzymes and small molecule catalysts. Proceedings of the National Academy of Sciences of the United States of America. 107: 20678-85. PMID 20956302 DOI: 10.1073/Pnas.1006402107  0.548
2010 Van Humbeck JF, Simonovich SP, Knowles RR, MacMillan DW. Concerning the mechanism of the FeCl3-catalyzed alpha-oxyamination of aldehydes: evidence for a non-SOMO activation pathway. Journal of the American Chemical Society. 132: 10012-4. PMID 20608675 DOI: 10.1021/Ja1043006  0.692
2010 Knowles RR, Lin S, Jacobsen EN. Enantioselective thiourea-catalyzed cationic polycyclizations. Journal of the American Chemical Society. 132: 5030-2. PMID 20369901 DOI: 10.1021/Ja101256V  0.65
2010 MacMillan D, Van Humbeck J, Simonovich S, Knowles R. A Closed-Shell Mechanism Alternative for Sibi’s α-Oxyamination of Aldehydes Synfacts. 2010: 1191-1191. DOI: 10.1055/S-0030-1258679  0.7
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