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Yimon Aye, Ph.D. - Publications

Affiliations: 
2012-2018 Cornell University, Ithaca, NY, United States 
 2018- École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Huang KT, Ly P, Poganik JR, Parvez S, Long MJC, Aye Y. Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites. Journal of Visualized Experiments : Jove. PMID 37335096 DOI: 10.3791/64846  0.316
2022 Long MJC, Aye Y. Keap 1: the new Janus word on the block. Bioorganic & Medicinal Chemistry Letters. 128766. PMID 35537607 DOI: 10.1016/j.bmcl.2022.128766  0.301
2022 Zhao Y, Miranda Herrera PA, Chang D, Hamelin R, Long MJC, Aye Y. Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35082156 DOI: 10.1073/pnas.2120687119  0.322
2021 Long MJC, Kulkarni A, Aye Y. Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design? Chembiochem : a European Journal of Chemical Biology. PMID 33826211 DOI: 10.1002/cbic.202100051  0.606
2020 Long MJC, Rogg C, Aye Y. An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX. Accounts of Chemical Research. PMID 33228351 DOI: 10.1021/acs.accounts.0c00537  0.346
2020 Aye Y. Where Electrophile Signaling and Covalent Ligand-Target Mining Converge. Chimia. 74: 659-666. PMID 32958101 DOI: 10.2533/Chimia.2020.659  0.347
2020 Liu X, Long MJC, Hopkins BD, Luo C, Wang L, Aye Y. Precision Targeting of -Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing. Acs Central Science. 6: 892-902. PMID 32607436 DOI: 10.1021/Acscentsci.9B00893  0.322
2020 Poganik JR, Aye Y. Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals. Frontiers in Aging Neuroscience. 12: 1. PMID 32116644 DOI: 10.3389/Fnagi.2020.00001  0.395
2020 Long MJC, Urul DA, Aye Y. REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins. Methods in Enzymology. 633: 203-230. PMID 32046846 DOI: 10.1016/Bs.Mie.2019.02.039  0.412
2019 Long MJC, Zhao Y, Aye Y. Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis. Cell Chemical Biology. PMID 31836351 DOI: 10.1016/J.Chembiol.2019.11.012  0.361
2019 Long MJC, Van Hall-Beauvais A, Aye Y. The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase. Current Opinion in Chemical Biology. 54: 10-18. PMID 31734537 DOI: 10.1016/J.Cbpa.2019.09.003  0.307
2019 Long MJC, Wang L, Aye Y. Getting the right grip? How understanding electrophile selectivity profiles could illuminate our understanding of redox signaling. Antioxidants & Redox Signaling. PMID 31578876 DOI: 10.1089/Ars.2019.7894  0.413
2019 Long MJC, Liu X, Aye Y. Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity. Frontiers in Chemistry. 7: 125. PMID 30949469 DOI: 10.3389/Fchem.2019.00125  0.342
2019 Long MJ, Liu X, Aye Y. Genie in a bottle: controlled release helps tame natural polypharmacology? Current Opinion in Chemical Biology. 51: 48-56. PMID 30913473 DOI: 10.1016/J.Cbpa.2019.02.014  0.421
2019 Aye Y, Carroll KS. Redox Pathways in Chemical Toxicology. Chemical Research in Toxicology. 32: 341. PMID 30879299 DOI: 10.1021/Acs.Chemrestox.9B00084  0.334
2019 Khatri HR, Bhattarai B, Kaplan W, Li Z, Long MJC, Aye Y, Nagorny P. Modular total synthesis and cell-based anticancer activity evaluation of ouabagenin and other cardiotonic steroids with varying degrees of oxygenation. Journal of the American Chemical Society. PMID 30802047 DOI: 10.1021/Jacs.8B12870  0.588
2019 Parvez S, Long MJC, Poganik JR, Aye Y. Correction to Redox Signaling by Reactive Electrophiles and Oxidants. Chemical Reviews. PMID 30789714 DOI: 10.1021/Acs.Chemrev.9B00066  0.324
2019 Poganik JR, Long MJC, Aye Y. Interrogating Precision Electrophile Signaling. Trends in Biochemical Sciences. PMID 30765181 DOI: 10.1016/J.Tibs.2019.01.006  0.412
2018 Long M, Hnedzko D, Kim BK, Aye Y. Breaking the fourth wall: Modulating quaternary associations for protein regulation and drug discovery. Chembiochem : a European Journal of Chemical Biology. PMID 30589188 DOI: 10.1002/Cbic.201800716  0.367
2018 Poganik JR, Aye Y. Weighing up the Selenocysteome Uncovers New Sec-rets. Cell Chemical Biology. 25: 1315-1317. PMID 30445052 DOI: 10.1016/J.Chembiol.2018.10.027  0.327
2018 Liu X, Long MJC, Aye Y. Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles. Trends in Biochemical Sciences. PMID 30327250 DOI: 10.1016/J.Tibs.2018.09.014  0.443
2018 Fu Y, Long MJC, Wisitpitthaya S, Inayat H, Pierpont TM, Elsaid IM, Bloom JC, Ortega J, Weiss RS, Aye Y. Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3. Nature Chemical Biology. PMID 30150681 DOI: 10.1038/S41589-018-0113-5  0.319
2018 Parvez S, Long MJC, Poganik JR, Aye Y. Redox Signaling by Reactive Electrophiles and Oxidants. Chemical Reviews. PMID 30148624 DOI: 10.1021/Acs.Chemrev.7B00698  0.402
2018 Van Hall-Beauvais A, Zhao Y, Urul DA, Long MJC, Aye Y. Single-Protein-Specific Redox Targeting in Live Mammalian Cells and C. elegans. Current Protocols in Chemical Biology. e43. PMID 30085412 DOI: 10.1002/Cpch.43  0.399
2018 Poganik JR, Long MJC, Aye Y. Getting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling Mediators. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e1700240. PMID 29603288 DOI: 10.1002/Bies.201700240  0.419
2018 Zhao Y, Long MJC, Wang Y, Zhang S, Aye Y. Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses. Acs Central Science. 4: 246-259. PMID 29532025 DOI: 10.1021/Acscentsci.7B00556  0.382
2018 Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 7. PMID 29460780 DOI: 10.7554/Elife.31502  0.501
2018 Surya SL, Long MJC, Urul DA, Zhao Y, Mercer EJ, Elsaid IM, Evans T, Aye Y. Cardiovascular small heat shock protein HSPB7 is a kinetically-privileged RES sensor. Acs Chemical Biology. PMID 29397684 DOI: 10.1021/Acschembio.7B00925  0.355
2018 Fu Y, Long MJC, Wisapitthaya S, Ortega J, Aye Y. Another piece of the jigsaw: a new signaling axis defined by shape-specific RNR-α hexamers Acta Crystallographica Section a Foundations and Advances. 74: a10-a10. DOI: 10.1107/S0108767318099890  0.338
2018 Aye Y. Targetable Reactive Electrophiles and Oxidants (T-REX) Technology to Identify "Privileged" Redox Sensors Free Radical Biology and Medicine. 128. DOI: 10.1016/J.Freeradbiomed.2018.10.378  0.459
2017 Long MJC, Urul DA, Chawla S, Lin HY, Zhao Y, Haegele JA, Wang Y, Aye Y. Precision electrophile tagging in C. elegans. Biochemistry. PMID 28857552 DOI: 10.1021/Acs.Biochem.7B00642  0.415
2017 Long MJ, Lin HY, Parvez S, Zhao Y, Poganik JR, Huang P, Aye Y. β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Cell Chemical Biology. PMID 28736239 DOI: 10.1016/J.Chembiol.2017.06.009  0.311
2017 Long MJC, Aye Y. Privileged Electrophile Sensors: A Resource for Covalent Drug Development. Cell Chemical Biology. PMID 28648380 DOI: 10.1016/J.Chembiol.2017.05.023  0.414
2017 Long MJ, Parvez S, Zhao Y, Surya SL, Wang Y, Zhang S, Aye Y. Akt3 is a privileged first responder in isozyme-specific electrophile response. Nature Chemical Biology. PMID 28114274 DOI: 10.1038/Nchembio.2284  0.382
2017 Long MJ, Poganik JR, Ghosh S, Aye Y. Subcellular Redox Targeting: Bridging In Vitro and In Vivo Chemical Biology. Acs Chemical Biology. PMID 28068059 DOI: 10.1021/Acschembio.6B01148  0.684
2016 Parvez S, Long MJ, Lin HY, Zhao Y, Haegele JA, Pham VN, Lee DK, Aye Y. T-REX on-demand redox targeting in live cells. Nature Protocols. 11: 2328-2356. PMID 27809314 DOI: 10.1038/Nprot.2016.114  0.421
2016 Long MJ, Aye Y. The Die is Cast: Precision electrophilic modifications contribute to cellular decision making. Chemical Research in Toxicology. PMID 27617777 DOI: 10.1021/Acs.Chemrestox.6B00261  0.438
2016 Wisitpitthaya S, Zhao Y, Long MJ, Li M, Fletcher EA, Blessing WA, Weiss RS, Aye Y. Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition. Acs Chemical Biology. PMID 27159113 DOI: 10.1021/Acschembio.6B00303  0.381
2016 Long MJ, Poganik JR, Aye Y. On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry. Journal of the American Chemical Society. PMID 26907082 DOI: 10.1021/Jacs.5B12608  0.405
2015 Lin HY, Haegele JA, Disare MT, Lin Q, Aye Y. A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling. Journal of the American Chemical Society. 137: 6232-44. PMID 25909755 DOI: 10.1021/Ja5132648  0.466
2015 Parvez S, Fu Y, Li J, Long MJ, Lin HY, Lee DK, Hu GS, Aye Y. Substoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant response. Journal of the American Chemical Society. 137: 10-3. PMID 25544059 DOI: 10.1021/Ja5084249  0.395
2014 Fu Y, Lin HY, Wisitpitthaya S, Blessing WA, Aye Y. A fluorimetric readout reporting the kinetics of nucleotide-induced human ribonucleotide reductase oligomerization. Chembiochem : a European Journal of Chemical Biology. 15: 2598-604. PMID 25256246 DOI: 10.1002/Cbic.201402368  0.344
2013 Fu Y, Long MJ, Rigney M, Parvez S, Blessing WA, Aye Y. Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase. Biochemistry. 52: 7050-9. PMID 24024562 DOI: 10.1021/Bi400781Z  0.312
2013 Fang X, Fu Y, Long MJ, Haegele JA, Ge EJ, Parvez S, Aye Y. Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells. Journal of the American Chemical Society. 135: 14496-9. PMID 24015839 DOI: 10.1021/Ja405400K  0.419
2012 Aye Y, Long MJ, Stubbe J. Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species. The Journal of Biological Chemistry. 287: 35768-78. PMID 22915594 DOI: 10.1074/Jbc.M112.396911  0.455
2012 Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chemistry & Biology. 19: 799-805. PMID 22840768 DOI: 10.1016/J.Chembiol.2012.05.015  0.542
2011 Aye Y, Stubbe J. Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit. Proceedings of the National Academy of Sciences of the United States of America. 108: 9815-20. PMID 21628579 DOI: 10.1073/Pnas.1013274108  0.484
2009 Curtis-Long MJ, Aye Y. Vinyl-, propargyl-, and allenylsilicon reagents in asymmetric synthesis: a relatively untapped resource of environmentally benign reagents. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 5402-16. PMID 19421982 DOI: 10.1002/Chem.200900337  0.308
2007 Evans DA, Aye Y. Aluminum-catalyzed enantio- and diastereoselective carbonyl addition of propargylsilanes. A new approach to enantioenriched vinyl epoxides. Journal of the American Chemical Society. 129: 9606-7. PMID 17636928 DOI: 10.1021/Ja0740420  0.436
2007 Evans DA, Aye Y. Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes Synfacts. 2007: 1171-1171. DOI: 10.1055/S-2007-991263  0.411
2006 Evans DA, Aye Y. Enantioselective scandium-catalyzed vinylsilane additions: a new approach to the synthesis of enantiopure beta,gamma-unsaturated alpha-hydroxy acid derivatives. Journal of the American Chemical Society. 128: 11034-5. PMID 16925415 DOI: 10.1021/Ja063878K  0.393
2006 Evans DA, Aye Y, Wu J. Asymmetric, anti-selective scandium-catalyzed Sakurai additions to glyoxyamide. Applications to the syntheses of N-boc D-alloisoleucine and D-isoleucine. Organic Letters. 8: 2071-3. PMID 16671784 DOI: 10.1021/Ol0604771  0.606
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