Michael A Geeves - Publications

Affiliations: 
1974-1977 Biochemsitry University of Bristol, Bristol, England, United Kingdom 
 1999- Biosciences University of Kent, Canterbury, England, United Kingdom 
Website:
https://www.kent.ac.uk/biosciences/people/1135/geeves-michael

218 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Childers MC, Geeves MA, Regnier M. An atomistic model of myosin interacting heads motif dynamics and their modification by 2'-deoxy-ADP. Biorxiv : the Preprint Server For Biology. PMID 38895221 DOI: 10.1101/2024.06.06.597809  0.345
2024 Rynkiewicz MJ, Childers MC, Karpicheva OE, Regnier M, Geeves MA, Lehman W. Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin. The Journal of General Physiology. 156. PMID 38607351 DOI: 10.1085/jgp.202413538  0.357
2023 Kao K, Geeves MA. Protocols for Myosin and Actin-Myosin Assays Using Rapid, Stopped-Flow Kinetics. Methods in Molecular Biology (Clifton, N.J.). 2735: 191-211. PMID 38038850 DOI: 10.1007/978-1-0716-3527-8_11  0.333
2022 Yampolskaya DS, Kopylova GV, Shchepkin DV, Nabiev SR, Nikitina LV, Walklate J, Ziganshin RH, Bershitsky SY, Geeves MA, Matyushenko AM, Levitsky DI. Pseudo-phosphorylation of essential light chains affects the functioning of skeletal muscle myosin. Biophysical Chemistry. 292: 106936. PMID 36436358 DOI: 10.1016/j.bpc.2022.106936  0.336
2022 Pilagov M, Heling LWHJ, Walklate J, Geeves MA, Kad NM. Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils. The Journal of General Physiology. 155. PMID 36394553 DOI: 10.1085/jgp.202213087  0.309
2022 Lee LA, Barrick SK, Meller A, Walklate J, Lotthammer JM, Tay JW, Stump WT, Bowman G, Geeves MA, Greenberg MJ, Leinwand LA. Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles. The Journal of Biological Chemistry. 102657. PMID 36334627 DOI: 10.1016/j.jbc.2022.102657  0.304
2022 Walklate J, Kao K, Regnier M, Geeves MA. Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle. The Journal of Biological Chemistry. 298: 101640. PMID 35090895 DOI: 10.1016/j.jbc.2022.101640  0.317
2021 Mijailovich SM, Prodanovic M, Poggesi C, Geeves MA, Regnier M. Multiscale modeling of twitch contractions in cardiac trabeculae. The Journal of General Physiology. 153. PMID 33512405 DOI: 10.1085/jgp.202012604  0.301
2020 Childers MC, Geeves M, Daggett V, Regnier M. Modulation of post-powerstroke dynamics in myosin II by 2'-deoxy-ADP. Archives of Biochemistry and Biophysics. 699: 108733. PMID 33388313 DOI: 10.1016/j.abb.2020.108733  0.34
2020 Bloemink MJ, Hsu KH, Geeves MA, Bernstein SI. Alternative N-terminal regions of myosin heavy chain II regulate communication of the purine binding loop with the essential light chain. The Journal of Biological Chemistry. PMID 32817166 DOI: 10.1074/Jbc.Ra120.014684  0.434
2020 Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophysical Journal. PMID 32730789 DOI: 10.1016/J.Bpj.2020.07.006  0.473
2020 Heling LWHJ, Geeves MA, Kad NM. MyBP-C: one protein to govern them all Journal of Muscle Research and Cell Motility. 41: 91-101. PMID 31960266 DOI: 10.1007/S10974-019-09567-1  0.368
2019 Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T. Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin. Nature Communications. 10: 4781. PMID 31636255 DOI: 10.1038/S41467-019-12667-8  0.464
2019 Vera CD, Johnson CA, Walklate J, Adhikari A, Svicevic M, Mijailovich SM, Combs AC, Langer SJ, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA. Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. The Journal of Biological Chemistry. PMID 31582565 DOI: 10.1074/Jbc.Ra119.010563  0.344
2019 Geeves MA, Lehrer SS, Lehman W. The mechanism of thin filament regulation: Models in conflict? The Journal of General Physiology. PMID 31570503 DOI: 10.1085/Jgp.201912446  0.395
2019 Baker K, Gyamfi IA, Mashanov GI, Molloy JE, Geeves MA, Mulvihill DP. TORC2-Gad8 dependent myosin phosphorylation modulates regulation by calcium. Elife. 8. PMID 31566560 DOI: 10.7554/Elife.51150  0.339
2019 Johnson CA, Walklate J, Svicevic M, Mijailovich SM, Vera CD, Karabina A, Leinwand LA, Geeves MA. The ATPase cycle of human muscle myosin II Isoforms: adaptation of a single mechanochemical cycle for different physiological roles. The Journal of Biological Chemistry. PMID 31387944 DOI: 10.1074/Jbc.Ra119.009825  0.406
2019 Walklate J, Ujfalusi Z, Behrens V, King EJ, Geeves MA. A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins. Analytical Biochemistry. PMID 31201789 DOI: 10.1016/J.Ab.2019.06.009  0.339
2019 Mijailovich SM, Stojanovic B, Nedic D, Svicevic M, Geeves MA, Irving TC, Granzier HL. Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity. The Journal of General Physiology. PMID 30948421 DOI: 10.1085/Jgp.201812165  0.448
2019 Mitrou GI, Sakkas GK, Poulianiti KP, Karioti A, Tepetes K, Christodoulidis G, Giakas G, Stefanidis I, Geeves MA, Koutedakis Y, Karatzaferi C. Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency. Journal of Biomechanics. 82: 259-265. PMID 30447801 DOI: 10.1016/J.Jbiomech.2018.10.035  0.317
2019 Mijailovich SM, Prodanovic M, Vasovic L, Stojanovic B, Maric M, Prodanovic D, Powers JD, Davis J, Geeves MA, Regnier M. Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments Biophysical Journal. 116: 116a. DOI: 10.1016/J.Bpj.2018.11.654  0.333
2018 Behrens VA, Walter WJ, Peters C, Wang T, Brenner B, Geeves MA, Scholz T, Steffen W. Mg -free ATP Regulates the Processivity of Native Cytoplasmic Dynein. Febs Letters. PMID 30575960 DOI: 10.1002/1873-3468.13319  0.343
2018 Ujfalusi Z, Vera CD, Mijailovich SM, Svicevic M, Yu EC, Kawana M, Ruppel K, Spudich JA, Geeves MA, Leinwand LA. Dilated cardiomyopathy myosin mutants have reduced force-generating capacity. The Journal of Biological Chemistry. PMID 29666183 DOI: 10.1074/Jbc.Ra118.001938  0.398
2018 Mijailovich SM, Nedic D, Stojanovic B, Powers JD, Davis J, Geeves MA, Regnier M. Influence of cTn Ca2+ Binding Properties and Cooperative Mechanisms on Cardiac Muscle Contractile Dynamics Biophysical Journal. 114: 500a. DOI: 10.1016/J.Bpj.2017.11.2737  0.367
2017 Johnson CA, Brooker HR, Gyamfi I, O'Brien J, Ashley B, Brazier JE, Dean A, Embling J, Grimsey E, Tomlinson AC, Wilson EG, Geeves MA, Mulvihill DP. Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on protein stability that destabilise the actin-tropomyosin copolymer in vitro and in vivo. Biochemical and Biophysical Research Communications. PMID 29080743 DOI: 10.1016/J.Bbrc.2017.10.109  0.402
2017 Karatzaferi C, Adamek N, Geeves MA. Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue. American Journal of Physiology. Cell Physiology. ajpcell.00023.2017. PMID 28931538 DOI: 10.1152/Ajpcell.00023.2017  0.396
2017 Mijailovich SM, Nedic D, Svicevic M, Stojanovic B, Walklate J, Ujfalusi Z, Geeves MA. Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms. Biophysical Journal. 112: 984-996. PMID 28297657 DOI: 10.1016/J.Bpj.2017.01.021  0.443
2017 Mijailovich SM, Nedic D, Stojanovic B, Irving TC, Geeves MA. Modulation of Fast Transients by Compliance of Crossbridges and Myofilaments Biophysical Journal. 112: 115a. DOI: 10.1016/J.Bpj.2016.11.649  0.383
2017 Inchingolo AV, Mihailescu MD, Dai H, Geeves MA, Kad NM. Single Molecule Imaging Reveals the Mechanism Ofactin.Tn.Tm Activation and Deactivation Biophysical Journal. 112: 10a. DOI: 10.1016/J.Bpj.2016.11.085  0.439
2016 Mijailovich SM, Kayser-Herold O, Stojanovic B, Nedic D, Irving TC, Geeves MA. Three-dimensional stochastic model of actin-myosin binding in the sarcomere lattice. The Journal of General Physiology. PMID 27864330 DOI: 10.1085/Jgp.201611608  0.45
2016 Brooker HR, Geeves MA, Mulvihill DP. Analysis of biophysical and functional consequences of tropomyosin-fluorescent protein fusions. Febs Letters. 590: 3111-21. PMID 27501521 DOI: 10.1002/1873-3468.12346  0.339
2016 Walklate J, Vera C, Bloemink MJ, Geeves MA, Leinwand L. The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects. The Journal of Biological Chemistry. 291: 10318-31. PMID 26945064 DOI: 10.1074/Jbc.M115.707489  0.407
2016 Walklate J, Ujfalusi Z, Geeves MA. Myosin isoforms and the mechanochemical cross-bridge cycle. The Journal of Experimental Biology. 219: 168-74. PMID 26792327 DOI: 10.1242/Jeb.124594  0.465
2016 Bloemink MJ, Melkani GC, Bernstein SI, Geeves MA. The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II. The Journal of Biological Chemistry. 291: 1763-73. PMID 26586917 DOI: 10.1074/Jbc.M115.688002  0.429
2016 Vera Velazquez CD, Walklate J, Geeves MA, Leinwand LA. β-MYHC Mutations Linked to Early-Onset HCM and DCM Show Differences in Pre-Steady and Steady State Kinetic Parameters Biophysical Journal. 110: 614a. DOI: 10.1016/J.Bpj.2015.11.3295  0.356
2016 Mijailovich SM, Nedic D, Svicevic M, Stojanovic B, Regnier M, Geeves MA. Dynamic Transient Responses of Muscle Fibers with a Heterogeneous Populations of Isoforms and Mutation Biophysical Journal. 110: 299a. DOI: 10.1016/J.Bpj.2015.11.1611  0.412
2016 Mijailovich SM, Stojanovic B, Nedic D, Geeves MA. Myosin Binding to Actin in the 3D Sarcomere Lattice Biophysical Journal. 110: 299a. DOI: 10.1016/J.Bpj.2015.11.1610  0.45
2015 Nag S, Sommese RF, Ujfalusi Z, Combs A, Langer S, Sutton S, Leinwand LA, Geeves MA, Ruppel KM, Spudich JA. Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. Science Advances. 1: e1500511. PMID 26601291 DOI: 10.1126/Sciadv.1500511  0.385
2015 Lehman W, Medlock G, Li XE, Suphamungmee W, Tu AY, Schmidtmann A, Ujfalusi Z, Fischer S, Moore JR, Geeves MA, Regnier M. Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain. Archives of Biochemistry and Biophysics. 571: 10-5. PMID 25726728 DOI: 10.1016/J.Abb.2015.02.026  0.425
2015 Desai R, Geeves MA, Kad NM. Using fluorescent myosin to directly visualize cooperative activation of thin filaments. The Journal of Biological Chemistry. 290: 1915-25. PMID 25429108 DOI: 10.1074/Jbc.M114.609743  0.447
2015 Geeves MA, Hitchcock-DeGregori SE, Gunning PW. A systematic nomenclature for mammalian tropomyosin isoforms. Journal of Muscle Research and Cell Motility. 36: 147-53. PMID 25369766 DOI: 10.1007/S10974-014-9389-6  0.392
2015 Mijailovich SM, Nedic D, Svicevic M, Stojanovic B, Geeves M. Modelling the Calcium Dependent Actin-Myosin ATP-ase Cycle in Solution Biophysical Journal. 108: 594a. DOI: 10.1016/J.Bpj.2014.11.3234  0.406
2015 Mijailovich SM, Stojanovic B, Nedic D, Geeves MA. Activation and Relaxation Kinetics in Skeletal and Cardiac Muscles Biophysical Journal. 108: 337a-338a. DOI: 10.1016/J.Bpj.2014.11.1843  0.419
2015 Velazquez CV, Walklate J, Deacon J, Geeves MA, Leinwand LA. Functional Analysis of Freeman-Sheldon Syndrome Causing Mutations on Embryonic Myosin Biophysical Journal. 108: 304a. DOI: 10.1016/J.Bpj.2014.11.1652  0.454
2015 Nedic D, Svicevic M, Stojanovic B, Geeves MA, Irving T, Gilbert RJ, Mijailovich SM. Effect of Mutations in cMyBP-C on Sarcomere Mechanical Function Biophysical Journal. 108: 200a. DOI: 10.1016/J.Bpj.2014.11.1108  0.407
2014 Geeves MA, Lehrer SS. Cross-talk, cross-bridges, and calcium activation of cardiac contraction. Biophysical Journal. 107: 543-545. PMID 25099792 DOI: 10.1016/J.Bpj.2014.06.019  0.387
2014 Adamek N, Geeves MA. Use of pyrene-labelled actin to probe actin-myosin interactions: kinetic and equilibrium studies. Experientia Supplementum (2012). 105: 87-104. PMID 25095992 DOI: 10.1007/978-3-0348-0856-9_5  0.416
2014 Lawrence AD, Taylor SL, Scott A, Rowe ML, Johnson CM, Rigby SE, Geeves MA, Pickersgill RW, Howard MJ, Warren MJ. FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR). Bioscience Reports. 34. PMID 24909839 DOI: 10.1042/Bsr20140060  0.312
2014 Lehrer SS, Geeves MA. The myosin-activated thin filament regulatory state, M- -open: A link to hypertrophic cardiomyopathy (HCM) Journal of Muscle Research and Cell Motility. 35: 153-160. PMID 24740688 DOI: 10.1007/S10974-014-9383-Z  0.387
2014 Bloemink M, Deacon J, Langer S, Vera C, Combs A, Leinwand L, Geeves MA. The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin. The Journal of Biological Chemistry. 289: 5158-67. PMID 24344137 DOI: 10.1074/Jbc.M113.511204  0.414
2014 Mijailovich SM, Nedic D, Stojanovic B, Geeves MA. Effect of Nonlinear Crossbridge Elasticity on Kinetics of Sarcomeric Contraction Biophysical Journal. 106: 158a. DOI: 10.1016/J.Bpj.2013.11.906  0.409
2014 Svicevic M, Mijailovich SM, Janco M, Geeves MA. Myosin Binding to Human Cardiac Thin Filaments Containing Tropomyosin Carrying DCM & HCM Mutations; Fitting of Complex Binding Transients Biophysical Journal. 106: 769a. DOI: 10.1016/J.Bpj.2013.11.4224  0.381
2014 Bloemink M, Deacon J, Langer S, Vera C, Combs A, Leinwand L, Geeves MA. The Hcm Mutation R453C in the Human Beta Myosin Motor Domain Alters the ATP-Binding and Hydrolysis Steps Biophysical Journal. 106: 561a. DOI: 10.1016/J.Bpj.2013.11.3119  0.456
2014 Medlock G, Suphamungmee W, Tu A, Li X(, Regnier M, Geeves MA, Lehman W. Effects of Phosphomimetic Mutations on the Persistence Length and Thin Filament Binding Properties of α and β-Tropomyosin Biophysical Journal. 106: 252a. DOI: 10.1016/J.Bpj.2013.11.1485  0.42
2013 Bloemink MJ, Deacon JC, Resnicow DI, Leinwand LA, Geeves MA. The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms. The Journal of Biological Chemistry. 288: 27469-79. PMID 23908353 DOI: 10.1074/Jbc.M113.488130  0.415
2013 Janco M, Suphamungmee W, Li X, Lehman W, Lehrer SS, Geeves MA. Polymorphism in tropomyosin structure and function. Journal of Muscle Research and Cell Motility. 34: 177-87. PMID 23832280 DOI: 10.1007/S10974-013-9353-X  0.346
2013 Mijailovich SM, Stojanovic B, Nedic D, Svicevic M, Gilbert RJ, Geeves MA, Irving T. Modulation of Crossbridge Cycling Kinetics and Length Dependent Calcium Sensitivity by Titin and Nebulin Biophysical Journal. 104: 310a. DOI: 10.1016/J.Bpj.2012.11.1723  0.422
2013 Nowakowski SG, Adamek N, Geeves MA, Gay E, Kolwicz SC, Murry CE, Daggett V, Regnier M. 2-deoxy-ATP Alters Myosin Structure to Enhance Cross-Bridge Cycling and Improve Cardiac Function Biophysical Journal. 104: 17a. DOI: 10.1016/J.Bpj.2012.11.125  0.466
2012 Janco M, Kalyva A, Scellini B, Piroddi N, Tesi C, Poggesi C, Geeves MA. α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains. Biochemistry. 51: 9880-90. PMID 23170982 DOI: 10.1021/Bi301323N  0.341
2012 Mijailovich SM, Kayser-Herold O, Li X, Griffiths H, Geeves MA. Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm-Tn chain. European Biophysics Journal : Ebj. 41: 1015-32. PMID 23052974 DOI: 10.1007/S00249-012-0859-8  0.452
2012 Geeves MA, Ranatunga KW. Tuning the calcium sensitivity of cardiac muscle. Biophysical Journal. 103: 849-50. PMID 23009833 DOI: 10.1016/J.Bpj.2012.07.039  0.45
2012 Deacon JC, Bloemink MJ, Rezavandi H, Geeves MA, Leinwand LA. Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors. Cellular and Molecular Life Sciences : Cmls. 69: 4239-55. PMID 23001010 DOI: 10.1007/S00018-012-1111-5  0.327
2012 Kalyva A, Schmidtmann A, Geeves MA. In vitro formation and characterization of the skeletal muscle α·β tropomyosin heterodimers. Biochemistry. 51: 6388-99. PMID 22812662 DOI: 10.1021/Bi300340R  0.371
2012 Li XE, Suphamungmee W, Janco M, Geeves MA, Marston SB, Fischer S, Lehman W. The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy Biochemical and Biophysical Research Communications. 424: 493-496. PMID 22789852 DOI: 10.1016/J.Bbrc.2012.06.141  0.459
2012 Canepari M, Maffei M, Longa E, Geeves M, Bottinelli R. Actomyosin kinetics of pure fast and slow rat myosin isoforms studied by in vitro motility assay approach. Experimental Physiology. 97: 873-81. PMID 22467761 DOI: 10.1113/Expphysiol.2012.064576  0.341
2012 Deacon JC, Bloemink MJ, Rezavandi H, Geeves MA, Leinwand LA. Identification of functional differences between recombinant human α and β cardiac myosin motors. Cellular and Molecular Life Sciences : Cmls. 69: 2261-77. PMID 22349210 DOI: 10.1007/S00018-012-0927-3  0.327
2012 Mijailovich SM, Li X, Griffiths RH, Geeves MA. The Hill model for binding myosin S1 to regulated actin is not equivalent to the McKillop-Geeves model. Journal of Molecular Biology. 417: 112-28. PMID 22306466 DOI: 10.1016/J.Jmb.2012.01.011  0.373
2012 Bloemink MJ, Melkani GC, Geeves MA, Bernstein SI. Kinetic Characterization of Converter and Relay Loop Domain Interaction in Drosophila Myosin Sub-Fragment 1 Biophysical Journal. 102: 149a. DOI: 10.1016/J.Bpj.2011.11.812  0.414
2012 Alexander CJ, Mulvihill DP, Geeves MA. Interactions of Calmodulin and the IQ Motifs of a Type I Myosin in Fission Yeast Biophysical Journal. 102: 566a. DOI: 10.1016/J.Bpj.2011.11.3086  0.441
2011 Bloemink MJ, Geeves MA. Shaking the myosin family tree: biochemical kinetics defines four types of myosin motor. Seminars in Cell & Developmental Biology. 22: 961-7. PMID 22001381 DOI: 10.1016/J.Semcdb.2011.09.015  0.394
2011 Korte FS, Dai J, Buckley K, Feest ER, Adamek N, Geeves MA, Murry CE, Regnier M. Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation. Journal of Molecular and Cellular Cardiology. 51: 894-901. PMID 21925507 DOI: 10.1016/J.Yjmcc.2011.08.026  0.367
2011 Preller M, Bauer S, Adamek N, Fujita-Becker S, Fedorov R, Geeves MA, Manstein DJ. Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V. The Journal of Biological Chemistry. 286: 35051-60. PMID 21841195 DOI: 10.1074/Jbc.M111.265298  0.337
2011 Rayes RF, Kálai T, Hideg K, Geeves MA, Fajer PG. Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe. Plos One. 6: e21277. PMID 21701580 DOI: 10.1371/Journal.Pone.0021277  0.342
2011 Bloemink MJ, Melkani GC, Dambacher CM, Bernstein SI, Geeves MA. Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities. The Journal of Biological Chemistry. 286: 28435-43. PMID 21680742 DOI: 10.1074/Jbc.M111.258228  0.414
2011 Geeves M, Griffiths H, Mijailovich S, Smith D. Cooperative [Ca²+]-dependent regulation of the rate of myosin binding to actin: solution data and the tropomyosin chain model. Biophysical Journal. 100: 2679-87. PMID 21641313 DOI: 10.1016/J.Bpj.2011.04.020  0.464
2011 Adamek N, Geeves MA, Coluccio LM. Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin. Cellular and Molecular Life Sciences : Cmls. 68: 139-50. PMID 20640478 DOI: 10.1007/S00018-010-0448-X  0.409
2011 Rezavandi H, Geeves MA. Kinetics of Mouse Alpha-Myosin S1 a Fast Myosin Biophysical Journal. 100: 454a. DOI: 10.1016/J.Bpj.2010.12.2677  0.423
2011 Deacon JC, Bloemink MJ, Geeves MA, Leinwand LA. Kinetic Analysis of Human α and β Cardiac Myosin Motor Domains Biophysical Journal. 100: 369a-370a. DOI: 10.1016/J.Bpj.2010.12.2204  0.321
2010 Adamek N, Lieto-Trivedi A, Geeves MA, Coluccio LM. Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear. Biochemistry. 49: 958-71. PMID 20039646 DOI: 10.1016/J.Bpj.2008.12.3864  0.45
2010 Rayes RF, Geeves MA, Fajer PG. EPR as a Tool to Study the Dynamic of Tropomyosin in the Muscle Fiber - Use of a Bifunctional Spin Label Biophysical Journal. 98: 351a. DOI: 10.1016/J.Bpj.2009.12.1898  0.396
2009 Albet-Torres N, Bloemink MJ, Barman T, Candau R, Frölander K, Geeves MA, Golker K, Herrmann C, Lionne C, Piperio C, Schmitz S, Veigel C, Månsson A. Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin. The Journal of Biological Chemistry. 284: 22926-37. PMID 19520847 DOI: 10.1074/Jbc.M109.019232  0.408
2009 Bloemink MJ, Dambacher CM, Knowles AF, Melkani GC, Geeves MA, Bernstein SI. Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head. Journal of Molecular Biology. 389: 707-21. PMID 19393244 DOI: 10.1016/J.Jmb.2009.04.036  0.384
2009 Rayes RF, Coulton AT, Geeves MA, Fajer PG. Dynamics of Bi-Functional Labeled Tropomyosin in Muscle Ghost Fiber Monitored by Saturation Transfer EPR Biophysical Journal. 96: 376a. DOI: 10.1016/J.Bpj.2008.12.2821  0.385
2009 Bloemink MJ, Dambacher CM, Melkani G, Geeves M, Bernstein SI. Kinetics Of Two Single Point Mutants Of Drosophila Myosin S1 Biophysical Journal. 96: 496a-497a. DOI: 10.1016/J.Bpj.2008.12.2563  0.378
2009 Albet-Torres N, Bloemink MJ, Barman T, Candau R, Geeves MA, Golker K, Herrmann C, Lionne C, Piperio C, Schmitz S, Veigel C, Mansson A. Drug Effects and Mechanism Underlying the Force-velocity Relationship of Skeletal Muscle Biophysical Journal. 96: 201a. DOI: 10.1016/J.Bpj.2008.12.1079  0.397
2008 Bernstein SI, Geeves MA. The XXXVII European muscle conference: Oxford September 2008. Journal of Muscle Research and Cell Motility. 29: 253-6. PMID 19034677 DOI: 10.1007/S10974-008-9151-Z  0.336
2008 Pearson DS, Swartz DR, Geeves MA. Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W. Biochemistry. 47: 12146-58. PMID 18942859 DOI: 10.1021/Bi801150W  0.372
2008 Smith DA, Geeves MA, Sleep J, Mijailovich SM. Towards a unified theory of muscle contraction. I: foundations. Annals of Biomedical Engineering. 36: 1624-40. PMID 18642081 DOI: 10.1007/S10439-008-9536-6  0.434
2008 Meshcheryakov V, Nitanai Y, Maytum R, Geeves MA, Maeda Y. Crystallization and preliminary X-ray crystallographic analysis of full-length yeast tropomyosin 2 from Saccharomyces cerevisiae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 528-30. PMID 18540067 DOI: 10.1107/S1744309108013110  0.312
2008 Adamek N, Coluccio LM, Geeves MA. Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear. Proceedings of the National Academy of Sciences of the United States of America. 105: 5710-5. PMID 18391215 DOI: 10.1073/Pnas.0710520105  0.359
2008 Tsiavaliaris G, Fujita-Becker S, Dürrwang U, Diensthuber RP, Geeves MA, Manstein DJ. Mechanism, regulation, and functional properties of Dictyostelium myosin-1B. The Journal of Biological Chemistry. 283: 4520-7. PMID 18089562 DOI: 10.1074/Jbc.M708113200  0.426
2008 Coulton AT, Koka K, Lehrer SS, Geeves MA. Role of the head-to-tail overlap region in smooth and skeletal muscle beta-tropomyosin. Biochemistry. 47: 388-97. PMID 18069797 DOI: 10.1021/Bi701144G  0.402
2008 Maytum R, Hatch V, Konrad M, Lehman W, Geeves MA. Ultra short yeast tropomyosins show novel myosin regulation. The Journal of Biological Chemistry. 283: 1902-10. PMID 18006493 DOI: 10.1074/Jbc.M708593200  0.434
2007 Bloemink MJ, Adamek N, Reggiani C, Geeves MA. Kinetic analysis of the slow skeletal myosin MHC-1 isoform from bovine masseter muscle. Journal of Molecular Biology. 373: 1184-97. PMID 17900618 DOI: 10.1016/J.Jmb.2007.08.050  0.401
2007 Boussouf SE, Agianian B, Bullard B, Geeves MA. The regulation of myosin binding to actin filaments by Lethocerus troponin. Journal of Molecular Biology. 373: 587-98. PMID 17868693 DOI: 10.1016/J.Jmb.2007.07.066  0.392
2007 Skoumpla K, Coulton AT, Lehman W, Geeves MA, Mulvihill DP. Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe. Journal of Cell Science. 120: 1635-45. PMID 17452625 DOI: 10.1242/Jcs.001115  0.43
2007 Málnási-Csizmadia A, Tóth J, Pearson DS, Hetényi C, Nyitray L, Geeves MA, Bagshaw CR, Kovács M. Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release. The Journal of Biological Chemistry. 282: 17658-64. PMID 17449872 DOI: 10.1074/Jbc.M701447200  0.618
2007 Boussouf SE, Maytum R, Jaquet K, Geeves MA. Role of tropomyosin isoforms in the calcium sensitivity of striated muscle thin filaments. Journal of Muscle Research and Cell Motility. 28: 49-58. PMID 17436057 DOI: 10.1007/S10974-007-9103-Z  0.39
2007 Miller BM, Bloemink MJ, Nyitrai M, Bernstein SI, Geeves MA. A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites. Journal of Molecular Biology. 368: 1051-66. PMID 17379245 DOI: 10.1016/J.Jmb.2007.02.042  0.417
2007 Boussouf SE, Geeves MA. Tropomyosin and troponin cooperativity on the thin filament. Advances in Experimental Medicine and Biology. 592: 99-109. PMID 17278359 DOI: 10.1007/978-4-431-38453-3_10  0.431
2007 Kintses B, Gyimesi M, Pearson DS, Geeves MA, Zeng W, Bagshaw CR, Málnási-Csizmadia A. Reversible movement of switch 1 loop of myosin determines actin interaction. The Embo Journal. 26: 265-74. PMID 17213877 DOI: 10.1038/Sj.Emboj.7601482  0.655
2007 Iorga B, Adamek N, Geeves MA. The slow skeletal muscle isoform of myosin shows kinetic features common to smooth and non-muscle myosins. The Journal of Biological Chemistry. 282: 3559-70. PMID 17130133 DOI: 10.1074/Jbc.M608191200  0.458
2006 Coulton A, Lehrer SS, Geeves MA. Functional homodimers and heterodimers of recombinant smooth muscle tropomyosin. Biochemistry. 45: 12853-8. PMID 17042503 DOI: 10.1021/Bi0613224  0.393
2006 Adio S, Bloemink M, Hartel M, Leier S, Geeves MA, Woehlke G. Kinetic and mechanistic basis of the nonprocessive Kinesin-3 motor NcKin3. The Journal of Biological Chemistry. 281: 37782-93. PMID 17012747 DOI: 10.1074/Jbc.M605061200  0.332
2006 Herm-Götz A, Delbac F, Weiss S, Nyitrai M, Stratmann R, Tomavo S, Sibley LD, Geeves MA, Soldati D. Functional and biophysical analyses of the class XIV Toxoplasma gondii myosin D. Journal of Muscle Research and Cell Motility. 27: 139-51. PMID 16470333 DOI: 10.1007/S10974-005-9046-1  0.321
2006 Dürrwang U, Fujita-Becker S, Erent M, Kull FJ, Tsiavaliaris G, Geeves MA, Manstein DJ. Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis. Journal of Cell Science. 119: 550-8. PMID 16443752 DOI: 10.1242/Jcs.02774  0.377
2006 Kremneva E, Nikolaeva O, Maytum R, Arutyunyan AM, Kleimenov SY, Geeves MA, Levitsky DI. Thermal unfolding of smooth muscle and nonmuscle tropomyosin alpha-homodimers with alternatively spliced exons. The Febs Journal. 273: 588-600. PMID 16420482 DOI: 10.1111/J.1742-4658.2005.05092.X  0.318
2006 Nyitrai M, Rossi R, Adamek N, Pellegrino MA, Bottinelli R, Geeves MA. What limits the velocity of fast-skeletal muscle contraction in mammals? Journal of Molecular Biology. 355: 432-42. PMID 16325202 DOI: 10.1016/J.Jmb.2005.10.063  0.416
2005 Geeves MA, Holmes KC. The molecular mechanism of muscle contraction. Advances in Protein Chemistry. 71: 161-93. PMID 16230112 DOI: 10.1016/S0065-3233(04)71005-0  0.455
2005 Nalavadi V, Nyitrai M, Bertolini C, Adamek N, Geeves MA, Bähler M. Kinetic mechanism of myosin IXB and the contributions of two class IX-specific regions. The Journal of Biological Chemistry. 280: 38957-68. PMID 16179355 DOI: 10.1074/Jbc.M507161200  0.467
2005 Clark R, Ansari MA, Dash S, Geeves MA, Coluccio LM. Loop 1 of transducer region in mammalian class I myosin, Myo1b, modulates actin affinity, ATPase activity, and nucleotide access. The Journal of Biological Chemistry. 280: 30935-42. PMID 15980431 DOI: 10.1074/Jbc.M504698200  0.466
2005 Geeves MA, Fedorov R, Manstein DJ. Molecular mechanism of actomyosin-based motility. Cellular and Molecular Life Sciences : Cmls. 62: 1462-77. PMID 15924264 DOI: 10.1007/S00018-005-5015-5  0.418
2005 Fujita-Becker S, Dürrwang U, Erent M, Clark RJ, Geeves MA, Manstein DJ. Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin. The Journal of Biological Chemistry. 280: 6064-71. PMID 15579903 DOI: 10.1074/Jbc.M412473200  0.371
2004 Nyitrai M, Geeves MA. Adenosine diphosphate and strain sensitivity in myosin motors. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 1867-77. PMID 15647162 DOI: 10.1098/Rstb.2004.1560  0.399
2004 Kremneva E, Boussouf S, Nikolaeva O, Maytum R, Geeves MA, Levitsky DI. Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin. Biophysical Journal. 87: 3922-33. PMID 15454401 DOI: 10.1529/Biophysj.104.048793  0.309
2004 Shimada A, Nyitrai M, Vetter IR, Kühlmann D, Bugyi B, Narumiya S, Geeves MA, Wittinghofer A. The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Molecular Cell. 13: 511-22. PMID 14992721 DOI: 10.1016/S1097-2765(04)00059-0  0.381
2004 Maytum R, Bathe F, Konrad M, Geeves MA. Tropomyosin exon 6b is troponin-specific and required for correct acto-myosin regulation. The Journal of Biological Chemistry. 279: 18203-9. PMID 14752114 DOI: 10.1074/Jbc.M311636200  0.422
2004 Crevel IM, Nyitrai M, Alonso MC, Weiss S, Geeves MA, Cross RA. What kinesin does at roadblocks: the coordination mechanism for molecular walking. The Embo Journal. 23: 23-32. PMID 14685258 DOI: 10.1038/Sj.Emboj.7600042  0.375
2004 Málnási-Csizmadia A, Pearson DS, Kovács M, Woolley RJ, Geeves MA, Bagshaw CR. Kinetic Resolution of a Conformational Transition and the ATP Hydrolysis Step Using Relaxation Methods with aDictyosteliumMyosin II Mutant Containing a Single Tryptophan Residue Biochemistry. 43: 14316-14316. DOI: 10.1021/Bi040043I  0.603
2003 Silva R, Sparrow JC, Geeves MA. Isolation and kinetic characterisation of myosin and myosin S1 from the Drosophila indirect flight muscles. Journal of Muscle Research and Cell Motility. 24: 489-98. PMID 14870964 DOI: 10.1023/B:Jure.0000009809.69829.74  0.473
2003 Clark RJ, Nyitrai M, Webb MR, Geeves MA. Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin. Journal of Muscle Research and Cell Motility. 24: 315-21. PMID 14620745 DOI: 10.1023/A:1025481908301  0.466
2003 Miller BM, Nyitrai M, Bernstein SI, Geeves MA. Kinetic analysis of Drosophila muscle myosin isoforms suggests a novel mode of mechanochemical coupling. The Journal of Biological Chemistry. 278: 50293-300. PMID 14506231 DOI: 10.1074/Jbc.M308318200  0.479
2003 Nyitrai M, Stafford WF, Szent-Györgyi AG, Geeves MA. Ionic interactions play a role in the regulatory mechanism of scallop heavy meromyosin. Biophysical Journal. 85: 1053-62. PMID 12885652 DOI: 10.1016/S0006-3495(03)74544-5  0.361
2003 Smith DA, Geeves MA. Cooperative regulation of myosin-actin interactions by a continuous flexible chain II: actin-tropomyosin-troponin and regulation by calcium. Biophysical Journal. 84: 3168-80. PMID 12719246 DOI: 10.1016/S0006-3495(03)70041-1  0.444
2003 Smith DA, Maytum R, Geeves MA. Cooperative regulation of myosin-actin interactions by a continuous flexible chain I: actin-tropomyosin systems. Biophysical Journal. 84: 3155-67. PMID 12719245 DOI: 10.1016/S0006-3495(03)70040-X  0.457
2003 Maytum R, Westerdorf B, Jaquet K, Geeves MA. Differential regulation of the actomyosin interaction by skeletal and cardiac troponin isoforms. The Journal of Biological Chemistry. 278: 6696-701. PMID 12475978 DOI: 10.1074/Jbc.M210690200  0.414
2003 Nyitrai M, Szent-Györgyi AG, Geeves MA. Interactions of the two heads of scallop (Argopecten irradians) heavy meromyosin with actin: influence of calcium and nucleotides. The Biochemical Journal. 370: 839-48. PMID 12441001 DOI: 10.1042/Bj20021519  0.442
2002 Tsiavaliaris G, Fujita-Becker S, Batra R, Levitsky DI, Kull FJ, Geeves MA, Manstein DJ. Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium. Embo Reports. 3: 1099-105. PMID 12393751 DOI: 10.1093/Embo-Reports/Kvf214  0.371
2002 Geeves MA, Trentham DR. Proteins: from chemical to physiological mechanism. European Biophysics Journal : Ebj. 31: 243-4. PMID 12122470 DOI: 10.1007/S00249-002-0231-5  0.546
2002 Nyitrai M, Szent-Györgyi AG, Geeves MA. A kinetic model of the co-operative binding of calcium and ADP to scallop (Argopecten irradians) heavy meromyosin. The Biochemical Journal. 365: 19-30. PMID 12071838 DOI: 10.1042/Bj20020099  0.336
2002 Maytum R, Geeves MA, Lehrer SS. A modulatory role for the troponin T tail domain in thin filament regulation. The Journal of Biological Chemistry. 277: 29774-80. PMID 12045197 DOI: 10.1074/Jbc.M201761200  0.484
2002 Pearson DS, Holtermann G, Ellison P, Cremo C, Geeves MA. A novel pressure-jump apparatus for the microvolume analysis of protein-ligand and protein-protein interactions: its application to nucleotide binding to skeletal-muscle and smooth-muscle myosin subfragment-1. The Biochemical Journal. 366: 643-51. PMID 12010120 DOI: 10.1042/Bj20020462  0.436
2002 Herm-Götz A, Weiss S, Stratmann R, Fujita-Becker S, Ruff C, Meyhöfer E, Soldati T, Manstein DJ, Geeves MA, Soldati D. Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor. The Embo Journal. 21: 2149-58. PMID 11980712 DOI: 10.1093/Emboj/21.9.2149  0.381
2002 Geeves MA, Lehrer SS. Modeling thin filament cooperativity [1] (multiple letters) Biophysical Journal. 82: 1677-1681. PMID 11898795 DOI: 10.1016/S0006-3495(02)75518-5  0.326
2002 Geeves MA, Lehrer SS. Cooperativity in the Ca2+ regulation of muscle contraction Results and Problems in Cell Differentiation. 36: 111-132. PMID 11892276 DOI: 10.1007/978-3-540-46558-4_10  0.39
2001 Málnási-Csizmadia A, Pearson DS, Kovács M, Woolley RJ, Geeves MA, Bagshaw CR. Kinetic resolution of a conformational transition and the ATP hydrolysis step using relaxation methods with a Dictyostelium myosin II mutant containing a single tryptophan residue. Biochemistry. 40: 12727-37. PMID 11601998 DOI: 10.1021/Bi010963Q  0.638
2001 Weiss S, Rossi R, Pellegrino MA, Bottinelli R, Geeves MA. Differing ADP release rates from myosin heavy chain isoforms define the shortening velocity of skeletal muscle fibers. The Journal of Biological Chemistry. 276: 45902-8. PMID 11590173 DOI: 10.1074/Jbc.M107434200  0.386
2001 Rogers KR, Weiss S, Crevel I, Brophy PJ, Geeves M, Cross R. KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry. The Embo Journal. 20: 5101-13. PMID 11566875 DOI: 10.1093/Emboj/20.18.5101  0.354
2001 Maytum R, Konrad M, Lehrer SS, Geeves MA. Regulatory properties of tropomyosin effects of length, isoform, and N-terminal sequence. Biochemistry. 40: 7334-41. PMID 11401582 DOI: 10.1021/Bi010072I  0.416
2001 Berger CE, Fagnant PM, Heizmann S, Trybus KM, Geeves MA. ADP binding induces an asymmetry between the heads of unphosphorylated myosin. The Journal of Biological Chemistry. 276: 23240-5. PMID 11301326 DOI: 10.1074/Jbc.M100524200  0.456
2001 Lohmann K, Westerdorf B, Maytum R, Geeves MA, Jaquet K. Overexpression of human cardiac troponin in Escherichia coli: its purification and characterization. Protein Expression and Purification. 21: 49-59. PMID 11162386 DOI: 10.1006/Prep.2000.1328  0.35
2000 Weiss S, Chizhov I, Geeves MA. A flash photolysis fluorescence/light scattering apparatus for use with sub microgram quantities of muscle proteins. Journal of Muscle Research and Cell Motility. 21: 423-32. PMID 11129433 DOI: 10.1023/A:1005690106951  0.452
2000 Maytum R, Geeves MA, Konrad M. Actomyosin regulatory properties of yeast tropomyosin are dependent upon N-terminal modification. Biochemistry. 39: 11913-20. PMID 11009604 DOI: 10.1021/Bi000977G  0.424
2000 Furch M, Remmel B, Geeves MA, Manstein DJ. Stabilization of the actomyosin complex by negative charges on myosin. Biochemistry. 39: 11602-8. PMID 10995227 DOI: 10.1021/Bi000985X  0.348
2000 Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R. Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. Journal of Molecular Biology. 302: 593-606. PMID 10986121 DOI: 10.1006/Jmbi.2000.4080  0.489
2000 Geeves MA, Chai M, Lehrer SS. Inhibition of actin-myosin subfragment 1 ATPase activity by troponin I and IC: Relationship to the thin filament states of muscle Biochemistry. 39: 9345-9350. PMID 10924128 DOI: 10.1021/Bi0002232  0.38
2000 Holmes KC, Geeves MA. The structural basis of muscle contraction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355: 419-31. PMID 10836495 DOI: 10.1098/Rstb.2000.0583  0.494
2000 Geeves MA, Perreault-Micale C, Coluccio LM. Kinetic analyses of a truncated mammalian myosin I suggest a novel isomerization event preceding nucleotide binding. The Journal of Biological Chemistry. 275: 21624-30. PMID 10781577 DOI: 10.1074/Jbc.M000342200  0.405
2000 Schmitz S, Clayton J, Nongthomba U, Prinz H, Veigel C, Geeves M, Sparrow J. Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function. Journal of Molecular Biology. 295: 1201-10. PMID 10653697 DOI: 10.1006/Jmbi.1999.3407  0.373
1999 Geeves MA, Holmes KC. Structural mechanism of muscle contraction. Annual Review of Biochemistry. 68: 687-728. PMID 10872464 DOI: 10.1146/Annurev.Biochem.68.1.687  0.451
1999 Geeves MA, Coluccio LM. The XXVIII European Muscle conference. York, UK, 4-7 September 1999. Journal of Muscle Research and Cell Motility. 20: 807-9. PMID 10730583 DOI: 10.1023/A:1005604902375  0.334
1999 Vawda F, Geeves MA, Ranatunga KW. Force generation upon hydrostatic pressure release in tetanized intact frog muscle fibres. Journal of Muscle Research and Cell Motility. 20: 477-88. PMID 10555066 DOI: 10.1023/A:1005565917768  0.33
1999 Razzaq A, Schmitz S, Veigel C, Molloy JE, Geeves MA, Sparrow JC. Actin residue glu(93) is identified as an amino acid affecting myosin binding. The Journal of Biological Chemistry. 274: 28321-8. PMID 10497190 DOI: 10.1074/Jbc.274.40.28321  0.457
1999 Coluccio LM, Geeves MA. Transient kinetic analysis of the 130-kDa myosin I (MYR-1 gene product) from rat liver. A myosin I designed for maintenance of tension? The Journal of Biological Chemistry. 274: 21575-80. PMID 10419463 DOI: 10.1074/Jbc.274.31.21575  0.461
1999 Schaertl S, Geeves MA, Konrad M. Human nucleoside diphosphate kinase B (Nm23-H2) from melanoma cells shows altered phosphoryl transfer activity due to the S122P mutation. The Journal of Biological Chemistry. 274: 20159-64. PMID 10400630 DOI: 10.1074/Jbc.274.29.20159  0.325
1999 Furch M, Fujita-Becker S, Geeves MA, Holmes KC, Manstein DJ. Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin. Journal of Molecular Biology. 290: 797-809. PMID 10395830 DOI: 10.1006/Jmbi.1999.2921  0.404
1999 Batra R, Geeves MA, Manstein DJ. Kinetic analysis of Dictyostelium discoideum myosin motor domains with glycine-to-alanine mutations in the reactive thiol region. Biochemistry. 38: 6126-34. PMID 10320339 DOI: 10.1021/Bi982251E  0.38
1999 Reiffert S, Maytum R, Geeves M, Lohmann K, Greis T, Blüggel M, Meyer HE, Heilmeyer LM, Jaquet K. Characterization of the cardiac holotroponin complex reconstituted from native cardiac troponin T and recombinant I and C. European Journal of Biochemistry. 261: 40-7. PMID 10103031 DOI: 10.1046/J.1432-1327.1999.00261.X  0.347
1999 Jacob M, Holtermann G, Perl D, Reinstein J, Schindler T, Geeves MA, Schmid FX. Microsecond folding of the cold shock protein measured by a pressure- jump technique Biochemistry. 38: 2882-2891. PMID 10074340 DOI: 10.1021/Bi982487I  0.333
1999 Maytum R, Lehrer SS, Geeves MA. Cooperativity and switching within the three-state model of muscle regulation. Biochemistry. 38: 1102-10. PMID 9894007 DOI: 10.1021/Bi981603E  0.419
1998 Geeves MA, Chizhov I. The use of fast kinetic systems for the study of ng-microgram quantities of purified muscle proteins. Advances in Experimental Medicine and Biology. 453: 79-88; discussion 88. PMID 9889817 DOI: 10.1007/978-1-4684-6039-1_10  0.437
1998 Conibear PB, Geeves MA. Cooperativity between the two heads of rabbit skeletal muscle heavy meromyosin in binding to actin. Biophysical Journal. 75: 926-37. PMID 9675193 DOI: 10.1016/S0006-3495(98)77581-2  0.455
1998 Friedman AL, Geeves MA, Manstein DJ, Spudich JA. Kinetic characterization of myosin head fragments with long-lived myosin.ATP states. Biochemistry. 37: 9679-87. PMID 9657680 DOI: 10.1021/Bi973143F  0.464
1998 Kurzawa-Goertz SE, Perreault-Micale CL, Trybus KM, Szent-Györgyi AG, Geeves MA. Loop I can modulate ADP affinity, ATPase activity, and motility of different scallop myosins. Transient kinetic analysis of S1 isoforms. Biochemistry. 37: 7517-25. PMID 9585566 DOI: 10.1021/Bi972844+  0.449
1998 Furch M, Geeves MA, Manstein DJ. Modulation of actin affinity and actomyosin adenosine triphosphatase by charge changes in the myosin motor domain. Biochemistry. 37: 6317-26. PMID 9572846 DOI: 10.1021/Bi972851Y  0.43
1998 Lehrer SS, Geeves MA. The muscle thin filament as a classical cooperative/allosteric regulatory system Journal of Molecular Biology. 277: 1081-1089. PMID 9571024 DOI: 10.1006/Jmbi.1998.1654  0.493
1998 Levitsky DI, Ponomarev MA, Geeves MA, Shnyrov VL, Manstein DJ. Differential scanning calorimetric study of the thermal unfolding of the motor domain fragments of Dictyostelium discoideum myosin II. European Journal of Biochemistry. 251: 275-80. PMID 9492294 DOI: 10.1046/J.1432-1327.1998.2510275.X  0.384
1998 Schaertl S, Konrad M, Geeves MA. Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis. The Journal of Biological Chemistry. 273: 5662-9. PMID 9488696 DOI: 10.1074/Jbc.273.10.5662  0.315
1998 Cremo CR, Geeves MA. Interaction of actin and ADP with the head domain of smooth muscle myosin: implications for strain-dependent ADP release in smooth muscle. Biochemistry. 37: 1969-78. PMID 9485324 DOI: 10.1021/Bi9722406  0.446
1997 Lehrer SS, Golitsina NL, Geeves MA. Actin-tropomyosin activation of myosin subfragment 1 ATPase and thin filament cooperativity. The role of tropomyosin flexibility and end-to-end interactions. Biochemistry. 36: 13449-54. PMID 9354612 DOI: 10.1021/Bi971568W  0.433
1997 Kurzawa SE, Manstein DJ, Geeves MA. Dictyostelium discoideum myosin II: characterization of functional myosin motor fragments. Biochemistry. 36: 317-23. PMID 9003183 DOI: 10.1021/Bi962166B  0.345
1996 Kurzawa SE, Geeves MA. A novel stopped-flow method for measuring the affinity of actin for myosin head fragments using microgram quantities of protein. Journal of Muscle Research and Cell Motility. 17: 669-76. PMID 8994086 DOI: 10.1007/Bf00154061  0.4
1996 Vawda F, Ranatunga KW, Geeves MA. Effects of hydrostatic pressure on fatiguing frog muscle fibres. Journal of Muscle Research and Cell Motility. 17: 631-6. PMID 8994082 DOI: 10.1007/Bf00154057  0.32
1996 Reiffert SU, Jaquet K, Heilmeyer LM, Ritchie MD, Geeves MA. Bisphosphorylation of cardiac troponin I modulates the Ca(2+)-dependent binding of myosin subfragment S1 to reconstituted thin filaments. Febs Letters. 384: 43-7. PMID 8797800 DOI: 10.1016/0014-5793(96)00274-8  0.429
1996 Anson M, Geeves MA, Kurzawa SE, Manstein DJ. Myosin motors with artificial lever arms. The Embo Journal. 15: 6069-6074. DOI: 10.1002/J.1460-2075.1996.Tb00995.X  0.394
1995 Smith DA, Geeves MA. Strain-dependent cross-bridge cycle for muscle. II. Steady-state behavior. Biophysical Journal. 69: 538-52. PMID 8527668 DOI: 10.1016/S0006-3495(95)79927-1  0.42
1995 Smith DA, Geeves MA. Strain-dependent cross-bridge cycle for muscle. Biophysical Journal. 69: 524-37. PMID 8527667 DOI: 10.1016/S0006-3495(95)79926-X  0.394
1995 Woodward SK, Geeves MA, Manstein DJ. Kinetic characterization of the catalytic domain of Dictyostelium discoideum myosin. Biochemistry. 34: 16056-64. PMID 8519762 DOI: 10.1021/Bi00049A020  0.429
1995 Schaertl S, Lehrer SS, Geeves MA. Separation and characterization of the two functional regions of troponin involved in muscle thin filament regulation. Biochemistry. 34: 15890-4. PMID 8519745 DOI: 10.1021/Bi00049A003  0.438
1995 Head JG, Ritchie MD, Geeves MA. Characterization of the equilibrium between blocked and closed states of muscle thin filaments. European Journal of Biochemistry. 227: 694-9. PMID 7867627 DOI: 10.1111/J.1432-1033.1995.0694P.X  0.394
1995 Geeves MA, Conibear PB, Lombardi V, Kawai M, Cooke R, Baskin R, Huxley H, Moore K, Hackney D. The role of three-state docking of myosin S1 with actin in force generation Biophysical Journal. 68: 194s-201s. PMID 7787067  0.334
1995 Anson M, Drummond DR, Geeves MA, Hennessey ES, Ritchie MD, Sparrow JC. Actomyosin kinetics and in vitro motility of wild-type Drosophila actin and the effects of two mutations in the Act88F gene. Biophysical Journal. 68: 1991-2003. PMID 7612841 DOI: 10.1016/S0006-3495(95)80376-0  0.46
1995 Geeves MA, Branson JP, Attwood PV. Kinetics of nucleotide binding to pyruvate carboxylase. Biochemistry. 34: 11846-54. PMID 7547919 DOI: 10.1021/Bi00037A024  0.374
1995 Vawda F, Ranatunga KW, Geeves MA. Pressure-induced changes in the isometric contractions of single intact frog muscle fibres at low temperatures. Journal of Muscle Research and Cell Motility. 16: 412-9. PMID 7499481 DOI: 10.1007/Bf00114506  0.326
1994 Fortune NS, Geeves MA, Ranatunga KW. Contractile activation and force generation in skinned rabbit muscle fibres: effects of hydrostatic pressure. The Journal of Physiology. 474: 283-90. PMID 8006815 DOI: 10.1113/Jphysiol.1994.Sp020021  0.363
1994 McKillop DF, Fortune NS, Ranatunga KW, Geeves MA. The influence of 2,3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres. Journal of Muscle Research and Cell Motility. 15: 309-18. PMID 7929796 DOI: 10.1007/Bf00123483  0.459
1994 Geeves MA, Lehrer SS. Dynamics of the muscle thin filament regulatory switch: The size of the cooperative unit Biophysical Journal. 67: 273-282. PMID 7918995 DOI: 10.1016/S0006-3495(94)80478-3  0.461
1993 Ritchie MD, Geeves MA, Woodward SK, Manstein DJ. Kinetic characterization of a cytoplasmic myosin motor domain expressed in Dictyostelium discoideum. Proceedings of the National Academy of Sciences of the United States of America. 90: 8619-23. PMID 8378339 DOI: 10.1073/Pnas.90.18.8619  0.493
1993 Knight PJ, Fortune NS, Geeves MA. Effects of pressure on equatorial x-ray fiber diffraction from skeletal muscle fibers. Biophysical Journal. 65: 814-22. PMID 8218906 DOI: 10.1016/S0006-3495(93)81111-1  0.332
1993 McKillop DF, Geeves MA. Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament. Biophysical Journal. 65: 693-701. PMID 8218897 DOI: 10.1016/S0006-3495(93)81110-X  0.401
1992 Ranatunga KW, Geeves MA. Changes produced by increased hydrostatic pressure in isometric contractions of rat fast muscle. The Journal of Physiology. 441: 423-31. PMID 1816380 DOI: 10.1113/Jphysiol.1991.Sp018759  0.321
1992 Geeves MA. The actomyosin ATPase: a two-state system. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 336: 63-70; discussion 70. PMID 1351298 DOI: 10.1098/Rstb.1992.0045  0.45
1991 Geeves MA, Goldmann WH. The influence of anions, ionic strength and organic solvents on the interaction between actin and myosin subfragment 1. Biochemical Society Transactions. 18: 584-5. PMID 2276448 DOI: 10.1042/Bst0180584  0.318
1991 Ranatunga KW, Fortune NS, Geeves MA. Hydrostatic compression in glycerinated rabbit muscle fibers. Biophysical Journal. 58: 1401-10. PMID 2275960 DOI: 10.1016/S0006-3495(90)82486-3  0.315
1991 McKillop DF, Geeves MA. Regulation of the acto.myosin subfragment 1 interaction by troponin/tropomyosin. Evidence for control of a specific isomerization between two acto.myosin subfragment 1 states. The Biochemical Journal. 279: 711-8. PMID 1953663 DOI: 10.1042/Bj2790711  0.462
1991 Geeves MA. The influence of pressure on actin and myosin interactions in solution and in single muscle fibres. Journal of Cell Science. Supplement. 14: 31-5. PMID 1885656 DOI: 10.1242/Jcs.1991.Supplement_14.7  0.378
1991 Fortune NS, Geeves MA, Ranatunga KW. Tension responses to rapid pressure release in glycerinated rabbit muscle fibers. Proceedings of the National Academy of Sciences of the United States of America. 88: 7323-7. PMID 1871140 DOI: 10.1073/Pnas.88.16.7323  0.336
1991 McKillop DF, Geeves MA, Balny C. The effect of hydrostatic pressure on the interaction of actomyosin subfragment 1 with nucleotides. Biochemical and Biophysical Research Communications. 180: 552-7. PMID 1835384 DOI: 10.1016/S0006-291X(05)81100-3  0.361
1991 Geeves MA. The dynamics of actin and myosin association and the crossbridge model of muscle contraction. The Biochemical Journal. 1-14. PMID 1825780 DOI: 10.1042/Bj2740001  0.398
1991 Woodward SK, Eccleston JF, Geeves MA. Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: characterization of two acto-S1-ADP complexes. Biochemistry. 30: 422-30. PMID 1824820 DOI: 10.1021/Bi00216A017  0.335
1991 Cross RA, Geeves MA, Kendrick-Jones J. A nucleation - Elongation mechanism for the self-assembly of side polar sheets of smooth muscle myosin Embo Journal. 10: 747-756. DOI: 10.1002/J.1460-2075.1991.Tb08006.X  0.395
1990 McKillop DF, Geeves MA. Effect of phosphate and sulphate on the interaction of actin and myosin subfragment 1. Biochemical Society Transactions. 18: 585-6. PMID 2276449 DOI: 10.1042/Bst0180585  0.378
1990 Nesterov VP, Peiper U, Hiller J, Krienke B, Schüttler K, Szymanski C, Bottinelli R, Cappelli V, Minelli R, Reggiani C, Schiaffino S, Carlhoff D, D'Haese J, Dabrowska R, Nowak E, ... ... Geeves MA, ... ... Geeves M, et al. Abstracts of the XVIII European Conference on Muscle and Motility Journal of Muscle Research & Cell Motility. 11: 56-78. DOI: 10.1007/Bf01833326  0.61
1989 Geeves MA. Dynamic interaction between actin and myosin subfragment 1 in the presence of ADP. Biochemistry. 28: 5864-71. PMID 2528376 DOI: 10.1021/Bi00440A024  0.359
1988 Millar NC, Geeves MA. Protein fluorescence changes associated with ATP and adenosine 5'-[gamma-thio]triphosphate binding to skeletal muscle myosin subfragment 1 and actomyosin subfragment 1. The Biochemical Journal. 249: 735-43. PMID 3355494 DOI: 10.1042/Bj2490735  0.404
1988 Geeves MA, Jeffries TE. The effect of nucleotide upon a specific isomerization of actomyosin subfragment 1 Biochemical Journal. 256: 41-46. PMID 3223909 DOI: 10.1042/Bj2560041  0.47
1988 Geeves MA, Ranatunga KW. Tension responses to increased hydrostatic pressure in glycerinated rabbit psoas muscle fibres. Proceedings of the Royal Society of London. Series B, Biological Sciences. 232: 217-26. PMID 2892206 DOI: 10.1098/Rspb.1987.0070  0.344
1987 Geeves MA, Jeffries TE, Millar NC. ATP-induced dissociation of rabbit skeletal actomyosin subfragment 1. Characterization of an isomerization of the ternary acto-S1-ATP complex. Biochemistry. 25: 8454-8. PMID 3828289 DOI: 10.1021/Bi00374A020  0.381
1987 Geeves MA, Halsall DJ. Two-step ligand binding and cooperativity. A model to describe the cooperative binding of myosin subfragment 1 to regulated actin. Biophysical Journal. 52: 215-20. PMID 3663829 DOI: 10.1016/S0006-3495(87)83208-3  0.433
1986 Geeves MA, Halsall DJ. The dynamics of the interaction between myosin subfragment 1 and pyrene-labelled thin filaments, from rabbit skeletal muscle. Proceedings of the Royal Society of London. Series B, Biological Sciences. 229: 85-95. PMID 2878438 DOI: 10.1098/Rspb.1986.0076  0.443
1985 Coates JH, Criddle AH, Geeves MA. Pressure-relaxation studies of pyrene-labelled actin and myosin subfragment 1 from rabbit skeletal muscle. Evidence for two states of acto-subfragment 1. The Biochemical Journal. 232: 351-6. PMID 4091793 DOI: 10.1042/Bj2320351  0.419
1985 Criddle AH, Geeves MA, Jeffries T. The use of actin labelled with N-(1-pyrenyl)iodoacetamide to study the interaction of actin with myosin subfragments and troponin/tropomyosin Biochemical Journal. 232: 343-349. PMID 3911945 DOI: 10.1042/Bj2320343  0.406
1984 Geeves MA, Goody RS, Gutfreund H. Kinetics of acto-S1 interaction as a guide to a model for the crossbridge cycle. Journal of Muscle Research and Cell Motility. 5: 351-61. PMID 6237117 DOI: 10.1007/Bf00818255  0.752
1983 Millar NC, Geeves MA. The limiting rate of the ATP-mediated dissociation of actin from rabbit skeletal muscle myosin subfragment 1. Febs Letters. 160: 141-8. PMID 6884503 DOI: 10.1016/0014-5793(83)80954-5  0.435
1982 Geeves MA, Gutfreund H. The use of pressure perturbations to investigate the interaction of rabbit muscle myosin subfragment 1 with actin in the presence of MgADP. Febs Letters. 140: 11-5. PMID 7084449 DOI: 10.1016/0014-5793(82)80509-7  0.406
1982 Geeves MA, Trentham DR. Protein-bound adenosine 5'-triphosphate: properties of a key intermediate of the magnesium-dependent subfragment 1 adenosinetriphosphatase from rabbit skeletal muscle. Biochemistry. 21: 2782-9. PMID 6124272 DOI: 10.1021/Bi00540A032  0.653
1980 Geeves MA, Webb MR, Midelfort CF, Trentham DR. Mechanism of adenosine 5'-triphosphate cleavage by myosin: studies with oxygen-18-labeled adenosine 5'-triphosphate. Biochemistry. 19: 4748-54. PMID 6448633  0.552
1979 Fink AL, Geeves MA. Cryoenzymology: the study of enzyme catalysis at subzero temperatures. Methods in Enzymology. 63: 336-70. PMID 41158 DOI: 10.1016/0076-6879(79)63015-X  0.503
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