Leslie A. Leinwand - Publications

Affiliations: 
Molecular, Cellular and Developmental Biology University of Colorado, Boulder, Boulder, CO, United States 
Area:
Medical Biophysics, Physiology Biology, Biochemistry

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Peter AK, Rossi AC, Buvoli M, Ozeroff CD, Crocini C, Perry AR, Buvoli AE, Lee LA, Leinwand LA. Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy. Journal of the American Heart Association. 8: e013318. PMID 31364453 DOI: 10.1161/Jaha.119.013318  0.304
2017 Luckey SW, Haines CD, Konhilas JP, Luczak ED, Messmer-Kratzsch A, Leinwand LA. Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy. Experimental Biology and Medicine (Maywood, N.J.). 1535370217731503. PMID 28901173 DOI: 10.1177/1535370217731503  0.687
2016 Peter AK, Bjerke MA, Leinwand LA. Biology of the cardiac myocyte in heart disease. Molecular Biology of the Cell. 27: 2149-60. PMID 27418636 DOI: 10.1091/Mbc.E16-01-0038  0.795
2016 Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science (New York, N.Y.). 351: 617-21. PMID 26912705 DOI: 10.1126/Science.Aad3456  0.316
2015 Hajj GP, Chu Y, Lund DD, Magida JA, Funk ND, Brooks RM, Baumbach GL, Zimmerman KA, Davis MK, El Accaoui RN, Hameed T, Doshi H, Chen B, Leinwand LA, Song LS, et al. Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 1653-62. PMID 25997932 DOI: 10.1161/Atvbaha.115.305729  0.778
2015 Konhilas JP, Chen H, Luczak E, McKee LA, Regan J, Watson PA, Stauffer BL, Khalpey ZI, Mckinsey TA, Horn T, LaFleur B, Leinwand LA. Diet and sex modify exercise and cardiac adaptation in the mouse. American Journal of Physiology. Heart and Circulatory Physiology. 308: H135-45. PMID 25398983 DOI: 10.1152/Ajpheart.00532.2014  0.677
2014 Magida JA, Leinwand LA. Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy. Embo Molecular Medicine. 6: 482-95. PMID 24567073 DOI: 10.1002/Emmm.201302852  0.802
2014 Bloemink M, Deacon J, Langer S, Vera C, Combs A, Leinwand L, Geeves MA. The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin. The Journal of Biological Chemistry. 289: 5158-67. PMID 24344137 DOI: 10.1074/Jbc.M113.511204  0.78
2013 Kucherlapati R, Leinwand LA. Frank Ruddle (1929-2013). American Journal of Human Genetics. 92: 839-40. PMID 24242788 DOI: 10.1016/J.Ajhg.2013.05.012  0.439
2013 Bloemink MJ, Deacon JC, Resnicow DI, Leinwand LA, Geeves MA. The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms. The Journal of Biological Chemistry. 288: 27469-79. PMID 23908353 DOI: 10.1074/Jbc.M113.488130  0.802
2013 Sommese RF, Sung J, Nag S, Sutton S, Deacon JC, Choe E, Leinwand LA, Ruppel K, Spudich JA. Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function. Proceedings of the National Academy of Sciences of the United States of America. 110: 12607-12. PMID 23798412 DOI: 10.1073/Pnas.1309493110  0.808
2012 Cosper PF, Harvey PA, Leinwand LA. Interferon-γ causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis. The American Journal of Pathology. 181: 2038-46. PMID 23058369 DOI: 10.1016/J.Ajpath.2012.08.040  0.752
2012 Deacon JC, Bloemink MJ, Rezavandi H, Geeves MA, Leinwand LA. Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors. Cellular and Molecular Life Sciences : Cmls. 69: 4239-55. PMID 23001010 DOI: 10.1007/S00018-012-1111-5  0.799
2012 Haines CD, Harvey PA, Luczak ED, Barthel KK, Konhilas JP, Watson PA, Stauffer BL, Leinwand LA. Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease. Endocrinology. 153: 4470-9. PMID 22778230 DOI: 10.1210/En.2012-1391  0.679
2012 Deacon JC, Bloemink MJ, Rezavandi H, Geeves MA, Leinwand LA. Identification of functional differences between recombinant human α and β cardiac myosin motors. Cellular and Molecular Life Sciences : Cmls. 69: 2261-77. PMID 22349210 DOI: 10.1007/S00018-012-0927-3  0.799
2012 Cosper PF, Leinwand LA. Myosin heavy chain is not selectively decreased in murine cancer cachexia. International Journal of Cancer. 130: 2722-7. PMID 21796617 DOI: 10.1002/Ijc.26298  0.734
2012 Sung J, Choe E, Elting M, Nag S, Sutton S, Deacon J, Leinwand L, Ruppel K, Spudich J. Single Molecule Studies of Recombinant Human α- and β-Cardiac Myosin to Elucidate Molecular Mechanism of Familial Hypertrophic and Dilated Cardiomyopathies Biophysical Journal. 102: 613a-614a. DOI: 10.1016/J.Bpj.2011.11.3345  0.801
2011 Riquelme CA, Magida JA, Harrison BC, Wall CE, Marr TG, Secor SM, Leinwand LA. Fatty acids identified in the Burmese python promote beneficial cardiac growth. Science (New York, N.Y.). 334: 528-31. PMID 22034436 DOI: 10.1126/Science.1210558  0.795
2011 Lemon DD, Horn TR, Cavasin MA, Jeong MY, Haubold KW, Long CS, Irwin DC, McCune SA, Chung E, Leinwand LA, McKinsey TA. Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. Journal of Molecular and Cellular Cardiology. 51: 41-50. PMID 21539845 DOI: 10.1016/J.Yjmcc.2011.04.005  0.797
2011 Luczak ED, Barthel KK, Stauffer BL, Konhilas JP, Cheung TH, Leinwand LA. Remodeling the cardiac transcriptional landscape with diet. Physiological Genomics. 43: 772-80. PMID 21487031 DOI: 10.1152/Physiolgenomics.00237.2010  0.699
2011 Cosper PF, Leinwand LA. Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Research. 71: 1710-20. PMID 21163868 DOI: 10.1158/0008-5472.Can-10-3145  0.751
2011 Deacon JC, Bloemink MJ, Geeves MA, Leinwand LA. Kinetic Analysis of Human α and β Cardiac Myosin Motor Domains Biophysical Journal. 100: 369a-370a. DOI: 10.1016/J.Bpj.2010.12.2204  0.781
2010 Resnicow DI, Deacon JC, Warrick HM, Spudich JA, Leinwand LA. Functional diversity among a family of human skeletal muscle myosin motors. Proceedings of the National Academy of Sciences of the United States of America. 107: 1053-8. PMID 20080549 DOI: 10.1073/Pnas.0913527107  0.802
2010 Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, ... ... Leinwand LA, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/J.Bbi.2009.08.004  0.597
2010 Resnicow DI, Deacon JC, Warrick HM, Spudich JA, Leinwand LA. Functional diversity among a family of human skeletal muscle myosin motors (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 3 (1053-1058) DOI: 10.1073/pnas.0913527107) Proceedings of the National Academy of Sciences of the United States of America. 107: 10765. DOI: 10.1073/pnas.1005980107  0.768
2009 Sloane E, Langer S, Jekich B, Mahoney J, Hughes T, Frank M, Seibert W, Huberty G, Coats B, Harrison J, Klinman D, Poole S, Maier S, Johnson K, Chavez R, ... ... Leinwand L, et al. Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain. Gene Therapy. 16: 1210-22. PMID 19571887 DOI: 10.1038/Gt.2009.79  0.627
2009 Hughes TS, Langer SJ, Virtanen SI, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression. The Journal of Gene Medicine. 11: 782-90. PMID 19533588 DOI: 10.1002/Jgm.1364  0.639
2009 Hughes TS, Langer SJ, Johnson KW, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 88-94. PMID 18941439 DOI: 10.1038/Mt.2008.230  0.644
2009 Luczak ED, Leinwand LA. Sex-based cardiac physiology. Annual Review of Physiology. 71: 1-18. PMID 18828746 DOI: 10.1146/Annurev.Physiol.010908.163156  0.697
2007 Sheren J, Langer SJ, Leinwand LA. A randomized library approach to identifying functional lox site domains for the Cre recombinase. Nucleic Acids Research. 35: 5464-73. PMID 17702764 DOI: 10.1093/Nar/Gkm604  0.776
2006 Milligan ED, Soderquist RG, Malone SM, Mahoney JH, Hughes TS, Langer SJ, Sloane EM, Maier SF, Leinwand LA, Watkins LR, Mahoney MJ. Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biology. 2: 293-308. PMID 18079973 DOI: 10.1017/S1740925X07000488  0.617
2006 Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 126: 294-308. PMID 16949747 DOI: 10.1016/J.Pain.2006.07.009  0.616
2006 Beylkin DH, Allen DL, Leinwand LA. MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes. Developmental Biology. 294: 541-53. PMID 16584724 DOI: 10.1016/J.Ydbio.2006.02.049  0.787
2006 Stauffer BL, Konhilas JP, Luczak ED, Leinwand LA. Soy diet worsens heart disease in mice. The Journal of Clinical Investigation. 116: 209-16. PMID 16395406 DOI: 10.1172/Jci24676  0.698
2006 Langer SJ, Busha D, Milligan ED, Hughes TS, Wieseler-Frank J, Watkins LR, Leinwand LA. 261. In Vivo Over-Expression of Fractalkine, a Putative Neuron-to-Glia Signal, To Characterize Underlying Mechanisms of Neuropathic Pain Molecular Therapy. 13: S100. DOI: 10.1016/J.Ymthe.2006.08.288  0.756
2006 Hughes T, Langer S, Sloane E, Mahoney J, Jekich B, Johnson K, Chavez R, Milligan E, Watkins L, Leinwand L. 260. ITRs Necessary for IL-10 Encoding Naked Plasmid Induced Reversal of Chronic Pain State in Rat Molecular Therapy. 13: S100. DOI: 10.1016/J.Ymthe.2006.08.287  0.626
2006 Milligan ED, Langer SJ, Hughes TS, Sloane EM, Mahoney JH, Jekich BM, Maier SF, Leinwand LA, Watkins LR. 259. Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) for Chronic Pain Control: Taking Advantage of Nuclear Scaffold/Matrix Attachment Regions Molecular Therapy. 13: S99. DOI: 10.1016/J.Ymthe.2006.08.286  0.628
2005 Allen DL, Weber JN, Sycuro LK, Leinwand LA. Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. The Journal of Biological Chemistry. 280: 17126-34. PMID 15728583 DOI: 10.1074/Jbc.M501207200  0.549
2005 Sheren JE, Ketner E, Keith J, Langer SJ, Leinwand LA. 1099. Beyond LoxP: Defining Functional Lox-Like Sequences for the Cre Recombinase Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.647  0.776
2005 Milligan ED, Mahoney MJ, Langer SJ, Hughes T, Sloane EM, Mahoney J, Jekich B, Cruz PE, Flotte TR, Maier SF, Johnson KW, Leinwand LA, Chavez RA, Watkins LR. 644. Gene Delivery for Chronic Pain Control: Micrcroencapsulated Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.184  0.622
2004 Masters KS, Shah DN, Walker G, Leinwand LA, Anseth KS. Designing scaffolds for valvular interstitial cells: cell adhesion and function on naturally derived materials. Journal of Biomedical Materials Research. Part A. 71: 172-80. PMID 15368267 DOI: 10.1002/Jbm.A.30149  0.559
2004 Walker GA, Masters KS, Shah DN, Anseth KS, Leinwand LA. Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circulation Research. 95: 253-60. PMID 15217906 DOI: 10.1161/01.Res.0000136520.07995.Aa  0.604
2003 Haubold KW, Allen DL, Capetanaki Y, Leinwand LA. Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1617-22. PMID 12844497 DOI: 10.1152/Japplphysiol.00408.2003  0.772
2003 Carnes J, Jacobson M, Leinwand L, Yarus M. Stop codon suppression via inhibition of eRF1 expression. Rna (New York, N.Y.). 9: 648-53. PMID 12756323 DOI: 10.1261/Rna.5280103  0.773
2003 Haubold K, Herrmann H, Langer SJ, Evans RM, Leinwand LA, Klymkowsky MW. Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes. Cell Motility and the Cytoskeleton. 54: 105-21. PMID 12529857 DOI: 10.1002/Cm.10090  0.8
2001 Walker GA, Guerrero IA, Leinwand LA. Myofibroblasts: molecular crossdressers. Current Topics in Developmental Biology. 51: 91-107. PMID 11236717 DOI: 10.1016/S0070-2153(01)51003-0  0.603
2000 Carnes J, Frolova L, Zinnen S, Drugeon G, Phillippe M, Justesen J, Haenni AL, Leinwand L, Kisselev LL, Yarus M. Suppression of eukaryotic translation termination by selected RNAs Rna. 6: 1468-1479. PMID 11073222 DOI: 10.1017/S1355838200001242  0.76
1999 Welikson RE, Buck SH, Patel JR, Moss RL, Vikstrom KL, Factor SM, Miyata S, Weinberger HD, Leinwand LA. Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice. American Journal of Physiology. Heart and Circulatory Physiology. 276: H2148-H2158. PMID 29592415 DOI: 10.1152/Ajpheart.1999.276.6.H2148  0.302
1999 Weiss A, McDonough D, Wertman B, Acakpo-Satchivi L, Montgomery K, Kucherlapati R, Leinwand L, Krauter K. Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. Proceedings of the National Academy of Sciences of the United States of America. 96: 2958-63. PMID 10077619 DOI: 10.1073/Pnas.96.6.2958  0.483
1997 Acakpo-Satchivi LJ, Edelmann W, Sartorius C, Lu BD, Wahr PA, Watkins SC, Metzger JM, Leinwand L, Kucherlapati R. Growth and muscle defects in mice lacking adult myosin heavy chain genes. The Journal of Cell Biology. 139: 1219-29. PMID 9382868 DOI: 10.1083/Jcb.139.5.1219  0.489
1992 Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L. Organization of the human skeletal myosin heavy chain gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 89: 12078-82. PMID 1465443 DOI: 10.1073/Pnas.89.24.12078  0.478
1982 Krauter K, Leinwand L, D'Eustachio P, Ruddle F, Darnell JE. Structural genes of the mouse major urinary protein are on chromosome 4. The Journal of Cell Biology. 94: 414-7. PMID 7107707 DOI: 10.1083/Jcb.94.2.414  0.424
1979 Leinwand L, Nichols E, Ruddle FH. Assignment of the gene for glyoxylase I to mouse chromosome 17 by somatic cell genetics. Biochemical Genetics. 16: 659-66. PMID 569476 DOI: 10.1007/Bf00484722  0.392
1979 Kozak CA, Fournier REK, Leinwand LA, Ruddle FH. Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids Biochemical Genetics. 17: 23-34. PMID 454358 DOI: 10.1007/Bf00484471  0.401
1979 Swan D, D'Eustachio P, Leinwand L, Seidman J, Keithley D, Ruddle FH. Chromosomal assignment of the mouse kappa light chain genes. Proceedings of the National Academy of Sciences of the United States of America. 76: 2735-9. PMID 111241 DOI: 10.1073/Pnas.76.6.2735  0.392
1978 Leinwand LA, Ruddle FH. Assignment of the gene for dipeptidase 2 to Mus musculus chromosome 18 by somatic cell hybridization Biochemical Genetics. 16: 477-484. PMID 736882 DOI: 10.1007/Bf00484213  0.41
1978 Leinwand LA, Kozak CA, Ruddle FH. Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization Somatic Cell Genetics. 4: 233-240. PMID 566475 DOI: 10.1007/Bf01538987  0.384
1978 Ruddle NH, Conta BS, Leinwand L, Kozak C, Ruddle F, Besmer P, Baltimore D. Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5 Journal of Experimental Medicine. 148: 451-465. PMID 212501 DOI: 10.1084/Jem.148.2.451  0.403
1978 Leinwand L, Fournier RE, Nichols EA, Ruddle FH. Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Cytogenetics and Cell Genetics. 21: 77-85. PMID 206412 DOI: 10.1159/000130880  0.404
1978 Leinwand L, Strair R, Ruddle FH. Phenotypic and molecular expression of albumin in rat hepatoma x L cell hybrids. Experimental Cell Research. 115: 261-8. PMID 28957 DOI: 10.1016/0014-4827(78)90280-X  0.387
1977 Leinwand L, Ruddle FH. Stimulation of in vitro translation of messenger RNA by actinomycin D and cordycepin. Science (New York, N.Y.). 197: 381-3. PMID 17919 DOI: 10.1126/Science.17919  0.392
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