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Bernhard Witkop - Publications

Affiliations: 
NIDDK National Institutes of Health, Bethesda, MD 
Area:
Protein chemistry
Website:
http://www.nasonline.org/member-directory/deceased-members/48995.html

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1998 CREVELING CR, DALY JW, WITKOP B, UNDENFRIEND S. Substrates and inhibitors of dopamine-beta-oxidase. Biochimica Et Biophysica Acta. 64: 125-34. PMID 14023834 DOI: 10.1016/0006-3002(62)90765-5  0.431
1998 DALY J, AXELROD J, WITKOP B. Methylation and demethylation in relation to the in vitro metabolism of mescaline. Annals of the New York Academy of Sciences. 96: 37-43. PMID 13883261 DOI: 10.1111/J.1749-6632.1962.Tb50099.X  0.411
1998 UDENFRIEND S, CREVELING CR, POSNER H, REDFIELD BG, DALY J, WITKOP B. On the inability of tryptamine to serve as a precursor of serotonin. Archives of Biochemistry and Biophysics. 83: 501-7. PMID 13855159 DOI: 10.1016/0003-9861(59)90058-X  0.324
1998 UDENFRIEND S, CREVELING CR, OZAKI M, DALY JW, WITKOP B. Inhibitors of norepinephrine metabolism in vivo. Archives of Biochemistry and Biophysics. 84: 249-51. PMID 13840157 DOI: 10.1016/0003-9861(59)90577-6  0.406
1978 Eldefrawi ME, Eldefrawi AT, Mansour NA, Daly JW, Witkop B, Albuquerque EX. Acetylcholine receptor and ionic channel of Torpedo electroplax: binding of perhydrohistrionicotoxin to membrane and solubilized preparations. Biochemistry. 17: 5474-84. PMID 728410 DOI: 10.1021/Bi00618A023  0.397
1977 Daly JW, Witkop B, Tokuyama T, Nishikawa T, Karle IL. Gephyrotoxins, histrionicotoxins and pumiliotoxins from the neotropical frog Dendrobates histrionicus. Helvetica Chimica Acta. 60: 1128-40. PMID 863724 DOI: 10.1002/Chin.197731320  0.374
1977 Eldefrawi AT, Eldefrawi ME, Albuquerque EX, Oliveira AC, Mansour N, Adler M, Daly JW, Brown GB, Burgermeister W, Witkop B. Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America. 74: 2172-6. PMID 301278 DOI: 10.1073/Pnas.74.5.2172  0.393
1976 Habermehl G, Andres H, Miyahara K, Witkop B, Daly JW. Synthese von Pumiliotoxin C Justus Liebigs Annalen Der Chemie. 1976: 1577-1583. DOI: 10.1002/Jlac.197619760906  0.427
1976 HABERMEHL G, ANDRES H, MIYAHARA K, WITKOP B, DALY JW. ChemInform Abstract: SYNTHESIS OF PUMILIOTOXIN C Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197651338  0.429
1975 Lapa AJ, Albuquerque EX, Sarvey JM, Daly J, Witkop B. Effects of histrionicotoxin on the chemosensitive and electrical properties of skeletal muscle. Experimental Neurology. 47: 558-80. PMID 1132464 DOI: 10.1016/0014-4886(75)90088-6  0.401
1974 Tokuyama T, Uenoyama K, Brown G, Daly JW, Witkop B. Allenic and acetylenic spiropiperidine alkaloids from the neotropical frog, Dendrobates histrionicus. Helvetica Chimica Acta. 57: 2597-604. PMID 4443292 DOI: 10.1002/Chin.197510439  0.429
1973 Albuquerque EX, Barnard EA, Chiu TH, Lapa AJ, Dolly JO, Jansson SE, Daly J, Witkop B. Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions. Proceedings of the National Academy of Sciences of the United States of America. 70: 949-53. PMID 4351811 DOI: 10.1073/Pnas.70.3.949  0.392
1972 Lutz WB, Creveling CR, Daly JW, Witkop B. Sulfur analogs of dopamine and norepinephrine. Inhibition of catechol-O-methyltransferase. Journal of Medicinal Chemistry. 15: 795-802. PMID 5044295 DOI: 10.1021/Jm00278A004  0.406
1972 Oesch F, Waters JA, Daly JW, Witkop B. Fluorescent derivatives of strophanthidin. Interaction with sodium- and potassium-activated adenosine triphosphatase. Journal of Medicinal Chemistry. 15: 757-9. PMID 4261402 DOI: 10.1021/Jm00277A015  0.397
1972 Daly JW, Jerina DM, Witkop B. Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds. Experientia. 28: 1129-49. PMID 4117670 DOI: 10.1007/Bf01946135  0.426
1972 LUTZ WB, CREVELING CR, DALY JW, WITKOP B, GOLDBERG LI. ChemInform Abstract: SCHWEFEL-ANALOGA VON DOPAMIN UND NOREPINEPHRIN, INHIBIERUNG DER CATECHOL-O-METHYL-TRANSFERASE Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197248266  0.417
1972 OESCH F, WATERS JA, DALY JW, WITKOP B. ChemInform Abstract: FLUORESZIERENDE DERIVATE DES STROPHANTHIDINS, DIE WECHSELWIRKUNG MIT NATRIUM- UND KALIUMAKTIVIERTER ADENOSINTRIPHOSPHATASE Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197246432  0.438
1971 Jerina DM, Daly JW, Witkop B. Migration of substituents during Hydroxylation of aromatic substrates (NIH shift). Oxidations with peroxytrifluoroacetic acid. Biochemistry. 10: 366-72. PMID 5543961 DOI: 10.1021/Bi00779A002  0.449
1971 Daly JW, Karle I, Myers CW, Tokuyama T, Waters JA, Witkop B. Histrionicotoxins: roentgen-ray analysis of the novel allenic and acetylenie spiroalkaloids isolated from a Colombian frog, Dendrobates histrionicus. Proceedings of the National Academy of Sciences of the United States of America. 68: 1870-5. PMID 5288773 DOI: 10.1073/Pnas.68.8.1870  0.407
1971 Daly J, Witkop B. Batrachotoxin, an extremely active cardio- and neurotoxin from the Colombian arrow poison frog Phyllobates aurotaenia. Clinical Toxicology. 4: 331-42. PMID 4363503 DOI: 10.3109/15563657108990484  0.304
1971 Albuquerque EX, Daly JW, Witkop B. Batrachotoxin: chemistry and pharmacology. Science (New York, N.Y.). 172: 995-1002. PMID 4324825 DOI: 10.1126/Science.172.3987.995  0.4
1971 ALBUQUERQUE EX, DALY JW, WITKOP B. ChemInform Abstract: BATRACHOTOXIN, CHEMIE UND PHARMAKOLOGIE Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/Chin.197141380  0.419
1970 Jerina DM, Daly JW, Witkop B, Zaltzman-Nirenberg P, Udenfriend S. 1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. Biochemistry. 9: 147-56. PMID 5411205 DOI: 10.1021/Bi00803A019  0.424
1970 Daly JW, Jerina DM, Ziffer H, Witkop B, Klärner FG, Vogel E. Enzymatic hydration of 8,9-indan oxide, Homoallylic addition of water. Journal of the American Chemical Society. 92: 702-3. PMID 5411062 DOI: 10.1021/ja00706a048  0.31
1970 Usubillaga A, Seelkopf C, Karle IL, Daly JW, Witkop B. The structure of solaphyllidine, a novel 4-ketosteroidal alkaloid. Journal of the American Chemical Society. 92: 700-1. PMID 5411061 DOI: 10.1021/Ja00706A047  0.422
1970 USUBILLAGA A, SEELKOPF C, KARLE IL, DALY JW, WITKOP B. ChemInform Abstract: STRUKTUR VON SOLAPHYLLIDIN, EINEM 4-KETO-STEROIDALKALOID Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197018420  0.427
1970 DALY JW, TOKUYAMA T, HABERMEHL G, KARLE IL, WITKOP B. ChemInform Abstract: FROSCHGIFTE, ISOLIERUNG UND STRUKTUR VON PUMILIOTOXIN C Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197011345  0.402
1969 Tokuyama T, Daly J, Witkop B. The structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, Phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs. Journal of the American Chemical Society. 91: 3931-8. PMID 5814950 DOI: 10.1021/Ja01042A042  0.456
1969 Karle IL, Daly JW, Witkop B. 2,3-cis-3,4-trans-3,4-dihydroxy-L-proline: mass spectrometry and X-ray analysis. Science (New York, N.Y.). 164: 1401-2. PMID 5783710 DOI: 10.1126/Science.164.3886.1401  0.43
1969 Creveling CR, Daly JW, Tokuyama T, Witkop B. Labile lipophilic derivatives of norepinephrine capable of crossing the blood-brain barrier. Experientia. 25: 26-7. PMID 5766567 DOI: 10.1007/Bf01903871  0.425
1969 Daly JW, Tokuyama T, Habermehl G, Karle I, Witkop B. [Frog venoms. Isolation and structure of pumiliotoxin]. Justus Liebigs Annalen Der Chemie. 729: 198-204. PMID 5364747 DOI: 10.1002/Jlac.19697290124  0.444
1968 Daly JW, Guroff G, Jerina DM, Udenfriend S, Witkop B. Intramolecular migrations of aryl substituents during enzymatic hydroxylation. Hoppe-Seyler's Zeitschrift Fã¼R Physiologische Chemie. 349: 1600-4. PMID 5745910  0.363
1968 Spector S, Tabei R, Creveling CR, Daly JW, Witkop B, Sjoerdsma A. Reduction of tissue norepinephrine and blood pressure by 3,5-dihydroxy-4-methoxy-phenylalanine. Life Sciences. 7: 943-9. PMID 5735321 DOI: 10.1016/0024-3205(68)90100-8  0.397
1968 Daly J, Jerina D, Witkop B. Migration of deuterium during hydroxylation of aromatic substrates by liver microsomes. I. Influence of ring substitutents. Archives of Biochemistry and Biophysics. 128: 517-27. PMID 5698035 DOI: 10.1016/0003-9861(68)90059-3  0.424
1968 Tokuyama T, Daly J, Witkop B, Karle IL, Karle J. The structure of batrachotoxinin A, a novel steroidal alkaloid from the Colombian arrow poison frog, Phyllobates aurotaenia. Journal of the American Chemical Society. 90: 1917-8. PMID 5689118 DOI: 10.1021/Ja01009A052  0.426
1968 Jerina DM, Daly JW, Witkop B, Zaltzman-Nirenberg P, Udenfriend S. The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. 3. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes. Journal of the American Chemical Society. 90: 6525-7. PMID 5682453 DOI: 10.1021/Ja01025A058  0.419
1968 Jerina DM, Daly JW, Witkop B. The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. II. Synthesis of 3,4-toluene-4-2H oxide and subsequent "NIH shift" to 4-hydroxytoluene-3-2H. Journal of the American Chemical Society. 90: 6523-5. PMID 5682452 DOI: 10.1021/Ja01025A057  0.433
1968 Creveling CR, Daly JW, Parfitt RT, Witkop B. The chemorelease of norepinephrine from mouse hearts. IV. Structure-activity relationships. Reserpines and yohimbines. Journal of Medicinal Chemistry. 11: 596-8. PMID 5656504 DOI: 10.1021/Jm00309A041  0.406
1968 Creveling CR, Daly JW, Witkop B. The chemorelease of norepinephrine from mouse hearts. 3. 3,5-Dihydroxy-4-methoxyphenethylamines and related compounds. Journal of Medicinal Chemistry. 11: 595-6. PMID 5656503 DOI: 10.1021/Jm00309A040  0.396
1968 Creveling CR, Daly J, Tokuyama T, Witkop B. The combined use of alpha-methyltyrosine and threo-dihydroxyphenylserine--selective reduction of dopamine levels in the central nervous system. Biochemical Pharmacology. 17: 65-70. PMID 5638559 DOI: 10.1016/0006-2952(68)90158-5  0.427
1968 Daly JW, Guroff G, Udenfriend S, Witkop B. Hydroxylation of alkyl and halogen substituted anilines and acetanilides by microsomal hydroxylases. Biochemical Pharmacology. 17: 31-6. PMID 5638557 DOI: 10.1016/0006-2952(68)90154-8  0.478
1968 Jerina D, Daly J, Witkop B, Zaltzman-Nirenberg P, Udenfriend S. Role of the arene oxide-oxepin system in the metabolism of aromatic substrates Archives of Biochemistry and Biophysics. 128: 176-183. DOI: 10.1016/0003-9861(68)90020-9  0.453
1967 Daly J, Guroff G, Udenfriend S, Witkop B. Hydroxylation-induced migrations of tritium in several substrates of liver aryl hydroxylases. Archives of Biochemistry and Biophysics. 122: 218-23. PMID 6076218 DOI: 10.1016/0003-9861(67)90142-7  0.443
1967 Creveling CR, Daly JW, Witkop B. The depletion of cardiac norepinephrine by 3,5-dihydroxy-4-methoxyphenethylamine and related compounds. The Journal of Pharmacology and Experimental Therapeutics. 158: 46-54. PMID 6054080  0.314
1967 Guroff G, Daly JW, Jerina DM, Renson J, Witkop B, Udenfriend S. Hydroxylation-induced migration: the NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds. Science (New York, N.Y.). 157: 1524-30. PMID 6038165 DOI: 10.1126/Science.157.3796.1524  0.424
1967 Udenfriend S, Zaltzman-Nirenberg P, Daly J, Guroff G, Chidsey C, Witkop B. Intramolecular migration of deuterium and tritium during enzymic hydroxylation of p-deuteroacetanilide and p-tritioacetanilide. Archives of Biochemistry and Biophysics. 120: 413-9. PMID 6033457 DOI: 10.1016/0003-9861(67)90258-5  0.41
1967 Daly JW, Mauger AB, Yonemitsu O, Antonov VK, Takase K, Witkop B. The synthesis and metabolism of 2,3-dihydro-L-tryptophan and 2,3-dihydro-5-hydroxy-DL-tryptophan. Biochemistry. 6: 648-54. PMID 5297946 DOI: 10.1021/Bi00855A002  0.436
1967 Jerina DM, Daly JW, Witkop B. Deuterium migration during the acid-catalyzed dehydration of 6-deuterio-5,6-dihydroxy-3-chloro-1,3-cyclohexadi-ene, a nonenzymic model for the NIH shift Journal of the American Chemical Society. 89: 5488-5489. DOI: 10.1021/Ja00997A053  0.433
1967 Jerina DM, Daly JW, Landis WR, Witkop B, Udenfriend S. Intramolecular migration of tritium and deuterium during nonenzymic aromatic hydroxylation Journal of the American Chemical Society. 89: 3347-3349. DOI: 10.1021/Ja00989A044  0.428
1966 Creveling CR, Daly JW, Witkop B. The depletion of norepinephrine-3H from heart by alpha-methyl-m-tyrosine. A novel and convenient method for assaying the inhibition of aromatic amino acid decarboxylase in vivo. Journal of Medicinal Chemistry. 9: 284-6. PMID 5960888 DOI: 10.1021/Jm00321A003  0.432
1966 Daly JW, Creveling CR, Witkop B. The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines. Journal of Medicinal Chemistry. 9: 273-80. PMID 5960887  0.328
1966 Daly JW, Creveling CR, Witkop B. The chemorelease of norepinephrine in mouse hearts. Structure-activity relationships. II. Drugs affecting the sympathetic and central nervous systems Journal of Medicinal Chemistry. 9: 280-284. PMID 4381277 DOI: 10.1021/JM00321A002  0.315
1966 Renson J, Daly J, Weissbach H, Witkop B, Udenfriend S. Enzymatic conversion of 5-tritiotryptophan to 4-tritio-5-hydroxytryptophan Biochemical and Biophysical Research Communications. 25: 504-513. DOI: 10.1016/0006-291X(66)90620-6  0.401
1965 Daly JW, Witkop B, Bommer P, Biemann K. Batrachotoxin. The active principle of the Colombian arrow poison frog, Phyllobates bicolor [6] Journal of the American Chemical Society. 87: 124-126. PMID 5826972 DOI: 10.1021/Ja01079A026  0.301
1965 Daly JW, Benigni J, Minnis R, Kanaoka Y, Witkop B. Synthesis and metabolism of 6-hydroxycatecholamines Biochemistry. 4: 2513-2525. DOI: 10.1021/Bi00887A035  0.416
1963 Daly JW, Witkop B. Recent Studies on the Centrally Active Endogenous Amines Angewandte Chemie International Edition in English. 2: 421-440. DOI: 10.1002/Anie.196304211  0.405
1963 Daly JW, Witkop B. Neuere Untersuchungen über zentral wirkende endogene endogene Amine Angewandte Chemie. 75: 552-572. DOI: 10.1002/Ange.19630751207  0.416
1962 Daly JW, Witkop B. The Synthesis and Properties of N,N-Dialkylaminovinylindoles The Journal of Organic Chemistry. 27: 4104-4106. DOI: 10.1021/JO01058A536  0.324
1961 Daly J, Horner L, Witkop B. Chemical and Enzymatic Routes to Methoxydopamines Journal of the American Chemical Society. 83: 4787-4792. DOI: 10.1021/Ja01484A022  0.4
1960 VISWANATHA T, LAWSON WB, WITKOP B. The action of N-bromosuccinimide on trypsinogen and its derivatives. Biochimica Et Biophysica Acta. 40: 216-24. PMID 13842490 DOI: 10.1016/0006-3002(60)91345-7  0.577
1960 Daly J, Durant RC, Friess SL, Holland GF, Kny H, Witkop B. Labilization of Ester Bonds in Aminocyclitol Derivatives. II. Polyacetates of Deoxystreptamine1 Journal of the American Chemical Society. 82: 5928-5934. DOI: 10.1021/Ja01507A033  0.416
1960 Cohen LA, Daly JW, Kny H, Witkop B. Nuclear Magnetic Resonance Spectra of Indoles Journal of the American Chemical Society. 82: 2184-2187. DOI: 10.1021/Ja01494A024  0.367
1959 Senoh S, Daly J, Axelrod J, Witkop B. Enzymatic p-O-Methylation by Catechol O-Methyl Transferase Journal of the American Chemical Society. 81: 6240-6245. DOI: 10.1021/Ja01532A031  0.399
1949 WOODWARD RB, WITKOP B. The structure of sempervirine. Journal of the American Chemical Society. 71: 379. PMID 18108979 DOI: 10.1021/Ja01169A523  0.601
1948 WOODWARD RB, WITKOP B. The structure of ketoyobyrine. Journal of the American Chemical Society. 70: 2409-12. PMID 18875105 DOI: 10.1021/Ja01187A028  0.601
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