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Hon Wai Lam, Ph.D - Publications

Affiliations: 
2002-2003 Chemistry Harvard University, Cambridge, MA, United States 
 2003-2013 Chemistry University of Edinburgh, Edinburgh, Scotland, United Kingdom 
 2013- Chemistry University of Nottingham, Nottingham, England, United Kingdom 
Area:
Organic synthesis, Catalysis
Website:
http://nottingham.ac.uk/chemistry/people/hon.lam
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80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Aguilar-Bejarano E, Özcan E, Rit RK, Li H, Lam HW, Moore JC, Woodward S, Figueredo G. Homogeneous catalyst graph neural network: A human-interpretable graph neural network tool for ligand optimization in asymmetric catalysis. Iscience. 28: 111881. PMID 40060895 DOI: 10.1016/j.isci.2025.111881  0.348
2023 Smith E, Jones KD, O'Brien L, Argent SP, Salome C, Lefebvre Q, Valery A, Böcü M, Newton GN, Lam HW. Silver(I)-Catalyzed Synthesis of Cuneanes from Cubanes and their Investigation as Isosteres. Journal of the American Chemical Society. PMID 37478562 DOI: 10.1021/jacs.3c03207  0.311
2022 Gillbard SM, Lam HW. Nickel-Catalyzed Arylative Cyclizations of Alkyne- and Allene-Tethered Electrophiles using Arylboron Reagents. Chemistry (Weinheim An Der Bergstrasse, Germany). e202104230. PMID 34986277 DOI: 10.1002/chem.202104230  0.534
2021 Gillbard SM, Green H, Argent SP, Lam HW. Enantioselective nickel-catalyzed -arylmetallative cyclizations onto acyclic electron-deficient alkenes. Chemical Communications (Cambridge, England). 57: 4436-4439. PMID 33949471 DOI: 10.1039/d1cc01166a  0.43
2021 Green H, Argent SP, Lam HW. Enantioselective Nickel-Catalyzed anti-Arylmetallative Cyclizations onto Acyclic Ketones. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33533065 DOI: 10.1002/chem.202100143  0.525
2020 Di Sanza R, Nguyen TLN, Iqbal N, Argent SP, Lewis W, Lam HW. Enantioselective nickel-catalyzed arylative and alkenylative intramolecular 1,2-allylations of tethered allene-ketones. Chemical Science. 11: 2401-2406. PMID 34084403 DOI: 10.1039/c9sc05246a  0.55
2020 Groves A, Sun J, Parke HRI, Callingham M, Argent SP, Taylor LJ, Lam HW. Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration. Chemical Science. 11: 2759-2764. PMID 34084335 DOI: 10.1039/c9sc06309a  0.509
2020 Groves A, Sun J, Parke HRI, Callingham M, Argent SP, Taylor LJ, Lam HW. Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration Chemical Science. 11: 2759-2764. DOI: 10.1039/C9Sc06309A  0.532
2020 Di Sanza R, Nguyen TLN, Iqbal N, Argent SP, Lewis W, Lam HW. Enantioselective nickel-catalyzed arylative and alkenylative intramolecular 1,2-allylations of tethered allene–ketones Chemical Science. 11: 2401-2406. DOI: 10.1039/C9Sc05246A  0.542
2019 O'Brien L, Karad SN, Lewis W, Lam HW. Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(i) migration. Chemical Communications (Cambridge, England). PMID 31478550 DOI: 10.1039/C9Cc05205D  0.519
2018 Ruscoe RE, Callingham M, Baker JA, Korkis SE, Lam HW. Iridium-catalyzed 1,5-(aryl)aminomethylation of 1,3-enynes by alkenyl-to-allyl 1,4-iridium(i) migration. Chemical Communications (Cambridge, England). PMID 30575828 DOI: 10.1039/c8cc09238a  0.485
2018 Panchal H, Clarke C, Bell C, Karad SN, Lewis W, Lam HW. Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols. Chemical Communications (Cambridge, England). PMID 30328418 DOI: 10.1039/C8Cc06388E  0.493
2018 Gillbard SM, Chung CH, Karad SN, Panchal H, Lewis W, Lam HW. Synthesis of multisubstituted pyrroles by nickel-catalyzed arylative cyclizations of N-tosyl alkynamides. Chemical Communications (Cambridge, England). PMID 30276371 DOI: 10.1039/C8Cc06649C  0.432
2018 Nguyen TLN, Incerti-Pradillos CA, Lewis W, Lam HW. Enantioselective nickel-catalyzed arylative intramolecular 1,4-allylations. Chemical Communications (Cambridge, England). PMID 29770399 DOI: 10.1039/C8Cc03204A  0.568
2018 Karad SN, Panchal H, Clarke C, Lewis W, Lam HW. Enantioselective Synthesis of Chiral Cyclopent-2-enones by Nickel-Catalyzed Desymmetrization of Malonate Esters. Angewandte Chemie (International Ed. in English). PMID 29768708 DOI: 10.1002/Anie.201805578  0.551
2018 Luo Y, Wales SM, Korkis SE, Roy ID, Lewis W, Lam HW. Switchable Synthesis of Z-Homoallylic Boronates and E-Allylic Boronates by Enantioselective Copper-Catalyzed 1,6-Boration. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29665113 DOI: 10.1002/Chem.201801804  0.309
2018 Dooley JD, Lam HW. One-Carbon Oxidative Annulations of 1,3-Enynes by Catalytic C-H Functionalization and 1,4-Rhodium(III) Migration. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29356188 DOI: 10.1002/chem.201706043  0.312
2017 Callingham M, Partridge BM, Lewis W, Lam HW. Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration. Angewandte Chemie (International Ed. in English). PMID 28980437 DOI: 10.1002/Anie.201709334  0.485
2017 Zhu S, Pathigoolla A, Lowe G, Walsh D, Cooper M, Lewis W, Lam HW. Sulfonylative and Azidosulfonylative Cyclizations by Visible-Light-Photosensitization of Sulfonyl Azides in THF. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28945301 DOI: 10.1002/Chem.201704380  0.664
2017 Yap C, Lenagh-Snow GM, Karad SN, Lewis W, Diorazio LJ, Lam HW. Enantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization. Angewandte Chemie (International Ed. in English). PMID 28544752 DOI: 10.1002/Anie.201703380  0.472
2017 Partridge BM, Callingham M, Lewis W, Lam HW. Arylative Intramolecular Allylation of Ketones with 1,3-Enynes Enabled by Catalytic Alkenyl-to-Allyl 1,4-Rhodium(I) Migration. Angewandte Chemie (International Ed. in English). PMID 28523779 DOI: 10.1002/Anie.201703155  0.524
2016 Korkis SE, Burns DJ, Lam HW. Rhodium-Catalyzed Oxidative C-H Allylation of Benzamides with 1,3-Dienes by Allyl-to-Allyl 1,4-Rh(III) Migration. Journal of the American Chemical Society. PMID 27545044 DOI: 10.1021/jacs.6b06884  0.407
2016 Clarke C, Incerti-Pradillos CA, Lam HW. Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization. Journal of the American Chemical Society. PMID 27333360 DOI: 10.1021/jacs.6b04206  0.377
2016 Martínez JI, Smith JJ, Hepburn HB, Lam HW. Chain Walking of Allylrhodium Species Towards Esters During Rhodium-Catalyzed Nucleophilic Allylations of Imines. Angewandte Chemie (International Ed. in English). 55: 1108-12. PMID 26756445 DOI: 10.1002/anie.201508964  0.392
2015 Burns AR, Madec AGE, Low DW, Roy ID, Lam HW. Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations. Chemical Science. 6: 3550-3555. PMID 29511516 DOI: 10.1039/c5sc00753d  0.519
2015 Reddy Chidipudi S, Burns DJ, Khan I, Lam HW. Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed CH Functionalization and Spiroannulation. Angewandte Chemie (International Ed. in English). PMID 26404643 DOI: 10.1002/anie.201507029  0.367
2015 Best D, Burns DJ, Lam HW. Direct Synthesis of 5-Aryl Barbituric Acids by Rhodium(II)-Catalyzed Reactions of Arenes with Diazo Compounds. Angewandte Chemie (International Ed. in English). 54: 7410-3. PMID 25959544 DOI: 10.1002/anie.201502324  0.392
2015 Burns AR, Madec AGE, Low DW, Roy ID, Lam HW. Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations Chemical Science. 6: 3550-3555. DOI: 10.1039/c5sc00753d  0.442
2014 Hepburn HB, Lam HW. The isomerization of allylrhodium intermediates in the rhodium-catalyzed nucleophilic allylation of cyclic imines. Angewandte Chemie (International Ed. in English). 53: 11605-10. PMID 25205604 DOI: 10.1002/anie.201407233  0.532
2014 Kujawa S, Best D, Burns DJ, Lam HW. Synthesis of spirocyclic enones by rhodium-catalyzed dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 8599-602. PMID 24909937 DOI: 10.1002/chem.201403454  0.404
2014 Partridge BM, Solana González J, Lam HW. Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration. Angewandte Chemie (International Ed. in English). 53: 6523-7. PMID 24842318 DOI: 10.1002/anie.201403271  0.434
2014 Lam HW, Man KY, Chan WW, Zhou Z, Yu WY. Rhodium(III)-catalyzed formal oxidative [4 + 1] cycloaddition of benzohydroxamic acids and α-diazoesters. A facile synthesis of functionalized benzolactams. Organic & Biomolecular Chemistry. 12: 4112-6. PMID 24788558 DOI: 10.1039/C4Ob00512K  0.373
2014 Luo Y, Roy ID, Madec AG, Lam HW. Enantioselective synthesis of allylboronates and allylic alcohols by copper-catalyzed 1,6-boration. Angewandte Chemie (International Ed. in English). 53: 4186-90. PMID 24623638 DOI: 10.1002/anie.201310380  0.455
2014 Roy ID, Burns AR, Pattison G, Michel B, Parker AJ, Lam HW. A second-generation ligand for the enantioselective rhodium-catalyzed addition of arylboronic acids to alkenylazaarenes. Chemical Communications (Cambridge, England). 50: 2865-8. PMID 24488116 DOI: 10.1039/C4Cc00340C  0.692
2014 Best D, Lam HW. C═N-containing azaarenes as activating groups in enantioselective catalysis. The Journal of Organic Chemistry. 79: 831-45. PMID 24341407 DOI: 10.1021/jo402414k  0.41
2014 Choi B, Saxena A, Smith JJ, Churchill GH, Lam HW. Enantioselective copper-catalyzed reductive coupling of vinylazaarenes with N -boc aldimines Synlett. 25. DOI: 10.1055/s-0034-1379548  0.308
2013 Simpson AJ, Lam HW. Enantioselective nickel-catalyzed Michael additions of 2-acetylazaarenes to nitroalkenes. Organic Letters. 15: 2586-9. PMID 23659368 DOI: 10.1021/ol400578c  0.605
2013 Reddy Chidipudi S, Wieczysty MD, Khan I, Lam HW. Synthesis of benzopyrans by Pd(II)- or Ru(II)-catalyzed C-H alkenylation of 2-aryl-3-hydroxy-2-cyclohexenones. Organic Letters. 15: 570-3. PMID 23317291 DOI: 10.1021/ol3033835  0.358
2013 Hepburn HB, Chotsaeng N, Luo Y, Lam H. Enantioselective rhodium-catalyzed allylation of cyclic imines with potassium allyltrifluoroborates Synthesis (Germany). 45: 2649-2661. DOI: 10.1055/s-0033-1339499  0.55
2012 Best D, Kujawa S, Lam HW. Diastereo- and enantioselective Pd(II)-catalyzed additions of 2-alkylazaarenes to N-Boc imines and nitroalkenes. Journal of the American Chemical Society. 134: 18193-6. PMID 23051617 DOI: 10.1021/ja3083494  0.39
2012 Burns AR, Solana González J, Lam HW. Enantioselective copper(I)-catalyzed borylative aldol cyclizations of enone diones. Angewandte Chemie (International Ed. in English). 51: 10827-31. PMID 23023759 DOI: 10.1002/anie.201205899  0.483
2012 Smith DL, Chidipudi SR, Goundry WR, Lam HW. Rhodium-catalyzed [2 + 2] cycloaddition of ynamides with nitroalkenes. Organic Letters. 14: 4934-7. PMID 22954424 DOI: 10.1021/ol302259v  0.546
2012 Fallan C, Lam HW. Enantioselective nickel-catalyzed Michael additions of azaarylacetates and acetamides to nitroalkenes. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 11214-8. PMID 22829526 DOI: 10.1002/chem.201202093  0.593
2012 Luo Y, Hepburn HB, Chotsaeng N, Lam HW. Enantioselective rhodium-catalyzed nucleophilic allylation of cyclic imines with allylboron reagents. Angewandte Chemie (International Ed. in English). 51: 8309-13. PMID 22786686 DOI: 10.1002/anie.201204004  0.575
2012 Luo Y, Carnell AJ, Lam HW. Enantioselective rhodium-catalyzed addition of potassium alkenyltrifluoroborates to cyclic imines. Angewandte Chemie (International Ed. in English). 51: 6762-6. PMID 22639334 DOI: 10.1002/anie.201202136  0.555
2012 Saxena A, Choi B, Lam HW. Enantioselective copper-catalyzed reductive coupling of alkenylazaarenes with ketones. Journal of the American Chemical Society. 134: 8428-31. PMID 22563725 DOI: 10.1021/ja3036916  0.495
2012 Low DW, Pattison G, Wieczysty MD, Churchill GH, Lam HW. Enantioselective Rh(I)-catalyzed cyclization of arylboron compounds onto ketones. Organic Letters. 14: 2548-51. PMID 22540631 DOI: 10.1021/Ol300845Q  0.722
2012 Best D, Burns AR, Pattison G, Lam HW. Heteroatom methods Annual Reports On the Progress of Chemistry - Section B. 108: 53-70. DOI: 10.1039/c2oc90009b  0.476
2011 Fallan C, Quigley PF, Lam HW. Ytterbium-catalyzed conjugate allylation of alkylidene malonates. The Journal of Organic Chemistry. 76: 4112-8. PMID 21524084 DOI: 10.1021/jo200268e  0.325
2011 Lam HW. TADDOL-derived phosphonites, phosphites, and phosphoramidites in asymmetric catalysis Synthesis. 2011-2043. DOI: 10.1055/s-0030-1260022  0.385
2011 Saxena A, Lam HW. Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes Chemical Science. 2: 2326-2331. DOI: 10.1039/c1sc00521a  0.323
2011 Chercheja S, Simpson JK, Lam HW. Base-catalyzed synthesis of bicyclic 4-aminopyrimidines from the reaction of dinitriles with mononitriles Tetrahedron. 67: 3839-3845. DOI: 10.1016/j.tet.2011.03.098  0.44
2010 Gourdet B, Lam HW. Catalytic asymmetric dihydroxylation of enamides and application to the total synthesis of (+)-tanikolide. Angewandte Chemie (International Ed. in English). 49: 8733-7. PMID 20886496 DOI: 10.1002/anie.201004328  0.356
2010 Pattison G, Piraux G, Lam HW. Enantioselective rhodium-catalyzed addition of arylboronic acids to alkenylheteroarenes. Journal of the American Chemical Society. 132: 14373-5. PMID 20879736 DOI: 10.1021/Ja106809P  0.706
2010 Gourdet B, Rudkin ME, Lam HW. Rhodium-catalyzed annulation of ynamides with bifunctional arylboron reagents. Organic Letters. 12: 2554-7. PMID 20446723 DOI: 10.1021/ol100769p  0.372
2010 Lam H, Pattison G, Piraux G. Asymmetric Rhodium-Catalyzed Addition of Arylboronic Acids to Alkenylheteroarenes Synfacts. 2011: 0061-0061. DOI: 10.1055/s-0030-1259108  0.641
2010 Brogan S, Carter NB, Lam HW. Copper-bisphosphine-initiated pentafluorophenylation of aldehydes and ketones Synlett. 615-617. DOI: 10.1055/s-0029-1219159  0.33
2010 Gourdet B, Smith DL, Lam HW. Rhodium-catalyzed carbometalation of ynamides with organoboron reagents Tetrahedron. 66: 6026-6031. DOI: 10.1016/j.tet.2010.06.021  0.546
2009 Oswald CL, Peterson JA, Lam HW. Enantioselective copper-catalyzed reductive Michael cyclizations. Organic Letters. 11: 4504-7. PMID 19810760 DOI: 10.1021/ol901560r  0.474
2009 Gourdet B, Rudkin ME, Watts CA, Lam HW. Preparation of multisubstituted enamides via rhodium-catalyzed carbozincation and hydrozincation of ynamides. The Journal of Organic Chemistry. 74: 7849-58. PMID 19754108 DOI: 10.1021/jo901658v  0.48
2009 Rupnicki L, Saxena A, Lam HW. Aromatic heterocycles as activating groups for asymmetric conjugate addition reactions. Enantioselective copper-catalyzed reduction of 2-alkenylheteroarenes. Journal of the American Chemical Society. 131: 10386-7. PMID 19722617 DOI: 10.1021/ja904365h  0.474
2009 Gourdet B, Lam HW. Stereoselective synthesis of multisubstituted enamides via rhodium-catalyzed carbozincation of ynamides. Journal of the American Chemical Society. 131: 3802-3. PMID 19253939 DOI: 10.1021/ja900946h  0.412
2009 Wang Y, Lam HW. Stereoselective formation of alkenyl halides via magnesium halide promoted ring opening of bis-activated cyclopropenes. The Journal of Organic Chemistry. 74: 1353-5. PMID 19115808 DOI: 10.1021/jo802475x  0.39
2008 Wang Y, Fordyce EA, Chen FY, Lam HW. Stereoselective synthesis of tri- and tetrasubstituted alkenes by iron-catalyzed carbometalation ring-opening reactions of cyclopropenes. Angewandte Chemie (International Ed. in English). 47: 7350-3. PMID 18702070 DOI: 10.1002/anie.200802391  0.365
2008 Rudkin ME, Joensuu PM, MacLachlan WS, Lam HW. Diastereoselective cobalt-catalyzed alkylative aldol cyclizations using trialkylaluminum reagents. Organic Letters. 10: 2939-42. PMID 18549223 DOI: 10.1021/ol800883b  0.571
2008 Joensuu PM, Murray GJ, Fordyce EA, Luebbers T, Lam HW. Diastereoselective nickel-catalyzed reductive aldol cyclizations using diethylzinc as the stoichiometric reductant: scope and mechanistic insight. Journal of the American Chemical Society. 130: 7328-38. PMID 18481861 DOI: 10.1021/ja0775624  0.344
2008 Fordyce EA, Wang Y, Luebbers T, Lam HW. Copper-catalyzed silylation of cyclopropenes using (trifluoromethyl)trimethylsilane. Chemical Communications (Cambridge, England). 1124-6. PMID 18292911 DOI: 10.1039/b717568j  0.397
2008 Prieto O, Lam HW. Cobalt-catalyzed reductive Mannich reactions of 4-acryloylmorpholine with N-tosyl aldimines. Organic & Biomolecular Chemistry. 6: 55-7. PMID 18075647 DOI: 10.1039/b715839d  0.333
2008 Villanueva Margalef I, Rupnicki L, Lam HW. Formal synthesis of salinosporamide A using a nickel-catalyzed reductive aldol cyclization-lactonization as a key step Tetrahedron. 64: 7896-7901. DOI: 10.1016/j.tet.2008.06.038  0.457
2008 Lumby RJR, Joensuu PM, Lam HW. ChemInform Abstract: Diastereoselective Intermolecular Cobalt-Catalyzed Reductive Aldol Reactions of α,β-Unsaturated Amides with Ketones. Cheminform. 39. DOI: 10.1002/CHIN.200814078  0.331
2007 Lumby RJ, Joensuu PM, Lam HW. Diastereoselective intermolecular cobalt-catalyzed reductive aldol reactions of alpha,beta-unsaturated amides with ketones. Organic Letters. 9: 4367-70. PMID 17867700 DOI: 10.1021/ol701980e  0.352
2007 Scansetti M, Hu X, McDermott BP, Lam HW. Synthesis of pyroglutamic acid derivatives via double michael reactions of alkynones. Organic Letters. 9: 2159-62. PMID 17455942 DOI: 10.1021/ol070674f  0.397
2006 Lam HW, Joensuu PM, Murray GJ, Fordyce EA, Prieto O, Luebbers T. Diastereoselective cobalt-catalyzed reductive aldol cyclizations using diethylzinc as the stoichiometric reductant. Organic Letters. 8: 3729-32. PMID 16898803 DOI: 10.1021/ol061329d  0.435
2006 Lam H, Joensuu P, Murray G, Fordyce E, Prieto O, Luebbers T. Co-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as Reductant Synfacts. 2006: 1153-1153. DOI: 10.1055/s-2006-949441  0.421
2005 Lam HW, Murray GJ, Firth JD. Diastereoselective synthesis of 4-hydroxypiperidin-2-ones via Cu(I)-catalyzed reductive aldol cyclization. Organic Letters. 7: 5743-6. PMID 16321037 DOI: 10.1021/ol052599j  0.498
2005 Lam HW, Joensuu PM. Cu(I)-catalyzed reductive aldol cyclizations: diastereo- and enantioselective synthesis of beta-hydroxylactones. Organic Letters. 7: 4225-8. PMID 16146393 DOI: 10.1002/CHIN.200604124  0.462
2003 Evans DA, Seidel D, Rueping M, Lam HW, Shaw JT, Downey CW. A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction. Journal of the American Chemical Society. 125: 12692-3. PMID 14558801 DOI: 10.1021/Ja0373871  0.708
2003 Evans DA, Scheidt KA, Fandrick KR, Lam HW, Wu J. Enantioselective indole Friedel--Crafts alkylations catalyzed by bis(oxazolinyl)pyridine-scandium(III) triflate complexes. Journal of the American Chemical Society. 125: 10780-1. PMID 12952445 DOI: 10.1021/ja036985c  0.76
2002 Lam HW, Pattenden G. Total synthesis of the presumed amphidinolide A. Angewandte Chemie (International Ed. in English). 41: 508-11. PMID 12491395 DOI: 10.1002/1521-3773(20020201)41:3<508::Aid-Anie508>3.0.Co;2-7  0.499
2000 Robertson J, Lam HW, Abazi S, Roseblade S, Lush RK. Radical Cascade Processes Leading to Fused- and Spiro-Bicyclic Ring Systems Tetrahedron. 56: 8959-8965. DOI: 10.1016/S0040-4020(00)00848-6  0.314
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