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Albert A. Bowers, Ph.D. - Publications

Affiliations: 
2007 University of Illinois at Chicago, Chicago, IL, United States 
Area:
radical chemistry
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Steude EG, Dieckhaus H, Pelton JM, Kuhlman B, Bowers AA. Assessing substrate scope of the cyclodehydratase LynD by mRNA display-enabled machine learning models. Biorxiv : the Preprint Server For Biology. PMID 39464139 DOI: 10.1101/2024.10.14.618330  0.345
2023 Iskandar SE, Chiou LF, Leisner TM, Shell DJ, Norris-Drouin JL, Vaziri C, Pearce KH, Bowers AA. Identification of Covalent Cyclic Peptide Inhibitors in mRNA Display. Journal of the American Chemical Society. PMID 37395736 DOI: 10.1021/jacs.3c04833  0.312
2022 Park R, Ongpipattanakul C, Nair SK, Bowers AA, Kuhlman B. Designer installation of a substrate recruitment domain to tailor enzyme specificity. Nature Chemical Biology. PMID 36509904 DOI: 10.1038/s41589-022-01206-0  0.329
2022 Bowler MM, Glavatskikh M, Pecot CV, Kireev D, Bowers AA. Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection. Acs Chemical Biology. PMID 36490372 DOI: 10.1021/acschembio.2c00828  0.321
2022 Rice AJ, Pelton JM, Kramer NJ, Catlin DS, Nair SK, Pogorelov TV, Mitchell DA, Bowers AA. Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis. Journal of the American Chemical Society. PMID 36351243 DOI: 10.1021/jacs.2c07377  0.402
2020 Bogart JW, Kramer NJ, Turlik A, Bleich RM, Catlin DS, Schroeder FC, Nair SK, Williamson RT, Houk KN, Bowers AA. Interception of the "Bycroft-Gowland" intermediate in the enzymatic macrocyclization of thiopeptides. Journal of the American Chemical Society. PMID 32609512 DOI: 10.1021/Jacs.0C05639  0.442
2020 Bird KE, Xander C, Murcia S, Schmalstig AA, Wang X, Emanuele MJ, Braunstein M, Bowers AA. Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy. Acs Chemical Biology. PMID 32589399 DOI: 10.1021/Acschembio.0C00364  0.351
2020 Puhl AC, Bogart JW, Haberman VA, Larson JE, Godoy AS, Norris-Drouin JL, Cholensky SH, Leisner TM, Frye SV, Parise LV, Bowers AA, Pearce KH. Discovery and Characterization of Peptide Inhibitors for CIB1. Acs Chemical Biology. PMID 32383857 DOI: 10.1021/Acschembio.0C00144  0.388
2020 Fleming SR, Himes PM, Ghodge SV, Goto Y, Suga H, Bowers AA. Exploring the Post-Translational Enzymology of PaaA by mRNA Display. Journal of the American Chemical Society. PMID 32109054 DOI: 10.1021/Jacs.0C01576  0.784
2019 Bogart JW, Bowers AA. Dehydroamino acids: chemical multi-tools for late-stage diversification. Organic & Biomolecular Chemistry. PMID 30849157 DOI: 10.1039/C8Ob03155J  0.419
2019 Farag S, Bleich RM, Shank EA, Isayev O, Bowers AA, Tropsha A. Inter-Modular Linkers play a crucial role in governing the biosynthesis of non-ribosomal peptides. Bioinformatics (Oxford, England). PMID 30785185 DOI: 10.1093/Bioinformatics/Btz127  0.418
2019 Bogart JW, Bowers AA. Thiopeptide Pyridine Synthase TbtD Catalyzes an Intermolecular Formal Aza-Diels-Alder Reaction. Journal of the American Chemical Society. PMID 30653303 DOI: 10.1021/Jacs.8B11852  0.369
2019 Fleming SR, Bartges TE, Vinogradov AA, Kirkpatrick CL, Goto Y, Suga H, Hicks LM, Bowers AA. Flexizyme-enabled benchtop biosynthesis of thiopeptides. Journal of the American Chemical Society. PMID 30602112 DOI: 10.1021/Jacs.8B11521  0.464
2019 Gutgsell AR, Ghodge SV, Bowers AA, Neher SB. Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition. The Journal of Biological Chemistry. 294: 2678-2689. PMID 30591589 DOI: 10.1074/Jbc.Ra118.005932  0.765
2018 Bowers AA. The substrate lends a hand. Nature Chemical Biology. 14: 907-908. PMID 30224692 DOI: 10.1038/S41589-018-0135-Z  0.409
2017 Bowers AA. Biosynthesis: Methylating mushrooms. Nature Chemical Biology. 13: 821-822. PMID 28853736 DOI: 10.1038/Nchembio.2437  0.391
2017 Grove TL, Himes PM, Hwang S, Yumerefendi H, Bonanno JB, Kuhlman B, Almo SC, Bowers AA. Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides. Journal of the American Chemical Society. PMID 28704043 DOI: 10.1021/Jacs.7B01283  0.384
2017 Gober JG, Ghodge SV, Bogart JW, Wever WJ, Watkins RR, Brustad EM, Bowers AA. P450-Mediated Non-natural Cyclopropanation of Dehydro-alanine-containing Thiopeptides. Acs Chemical Biology. PMID 28535034 DOI: 10.1021/Acschembio.7B00358  0.778
2017 Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nature Chemical Biology. PMID 28459440 DOI: 10.1038/Nchembio.2370  0.72
2017 Wang X, Arceci A, Bird K, Mills CA, Choudhury R, Kernan JL, Zhou C, Bae-Jump V, Bowers A, Emanuele MJ. VprBP/DCAF1 regulates the degradation and non-proteolytic activation of the cell cycle transcription factor FoxM1. Molecular and Cellular Biology. PMID 28416635 DOI: 10.1128/Mcb.00609-16  0.323
2016 Wever WJ, Bogart JW, Bowers AA. Identification of Pyridine Synthase Recognition Sequences Allows Modular Solid-Phase Route to Thiopeptide Variants. Journal of the American Chemical Society. PMID 27575591 DOI: 10.1021/Jacs.6B05389  0.746
2016 Ghodge SV, Biernat KA, Bassett SJ, Redinbo MR, Bowers AA. Post-Translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A. Journal of the American Chemical Society. PMID 27088303 DOI: 10.1021/Jacs.5B13529  0.802
2016 Himes PM, Allen SE, Hwang S, Bowers AA. Production of Sactipeptides in Escherichia coli: Probing the Substrate Promiscuity of Subtilosin A Biosynthesis. Acs Chemical Biology. PMID 27019323 DOI: 10.1021/Acschembio.6B00042  0.426
2015 Allen SE, Dokholyan NV, Bowers AA. Dynamic docking of conformationally constrained macrocycles: methods and applications. Acs Chemical Biology. PMID 26575401 DOI: 10.1021/Acschembio.5B00663  0.349
2015 Wever WJ, Bogart JW, Baccile JA, Chan AN, Schroeder FC, Bowers AA. Chemoenzymatic synthesis of thiazolyl peptide natural products featuring an enzyme-catalyzed formal [4 + 2] cycloaddition. Journal of the American Chemical Society. 137: 3494-7. PMID 25742119 DOI: 10.1021/Jacs.5B00940  0.765
2015 Dunn ZD, Wever WJ, Economou NJ, Bowers AA, Li B. Enzymatic basis of "hybridity" in thiomarinol biosynthesis. Angewandte Chemie (International Ed. in English). 54: 5137-41. PMID 25726835 DOI: 10.1002/Anie.201411667  0.731
2015 Bleich R, Watrous JD, Dorrestein PC, Bowers AA, Shank EA. Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America. 112: 3086-91. PMID 25713360 DOI: 10.1073/Pnas.1414272112  0.537
2015 Li B, Wever WJ, Walsh CT, Bowers AA. Correction: Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Natural Product Reports. 32: 348-9. PMID 25598489 DOI: 10.1039/C4Np90047B  0.746
2014 Li B, Wever WJ, Walsh CT, Bowers AA. Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Natural Product Reports. 31: 905-23. PMID 24835149 DOI: 10.1039/C3Np70106A  0.76
2013 Guerra-Bubb JM, Bowers AA, Smith WB, Paranal R, Estiu G, Wiest O, Bradner JE, Williams RM. Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs. Bioorganic & Medicinal Chemistry Letters. 23: 6025-8. PMID 24035339 DOI: 10.1016/J.Bmcl.2013.06.012  0.528
2013 Wever WJ, Cinelli MA, Bowers AA. Visible light mediated activation and O-glycosylation of thioglycosides. Organic Letters. 15: 30-3. PMID 23256636 DOI: 10.1021/Ol302941Q  0.668
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.718
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.714
2012 Li B, Forseth RR, Bowers AA, Schroeder FC, Walsh CT. A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus. Chembiochem : a European Journal of Chemical Biology. 13: 2521-6. PMID 23097183 DOI: 10.1002/Cbic.201200536  0.492
2012 Bowers AA, Acker MG, Young TS, Walsh CT. Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. Journal of the American Chemical Society. 134: 10313-6. PMID 22686940 DOI: 10.1021/ja302820x  0.732
2012 Bowers AA. Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries Medchemcomm. 3: 905-915. DOI: 10.1039/C2Md20068F  0.417
2012 Bowers AA. ChemInform Abstract: Biochemical and Biosynthetic Preparation of Natural Product Like Cyclic Peptide Libraries Cheminform. 43: no-no. DOI: 10.1002/CHIN.201244250  0.303
2010 Bowers AA, Walsh CT, Acker MG. Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus. Journal of the American Chemical Society. 132: 12182-4. PMID 20707374 DOI: 10.1021/Ja104524Q  0.556
2010 Walsh CT, Acker MG, Bowers AA. Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins. The Journal of Biological Chemistry. 285: 27525-31. PMID 20522549 DOI: 10.1074/Jbc.R110.135970  0.563
2010 Bowers AA, Acker MG, Koglin A, Walsh CT. Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. Journal of the American Chemical Society. 132: 7519-27. PMID 20455532 DOI: 10.1021/Ja102339Q  0.523
2009 Acker MG, Bowers AA, Walsh CT. Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. Journal of the American Chemical Society. 131: 17563-5. PMID 19911780 DOI: 10.1021/Ja908777T  0.568
2009 Newkirk TL, Bowers AA, Williams RM. Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors. Natural Product Reports. 26: 1293-320. PMID 19779641 DOI: 10.1039/B817886K  0.759
2009 Crich D, Sasaki K, Rahaman MY, Bowers AA. One-pot syntheses of dissymmetric diamides based on the chemistry of cyclic monothioanhydrides. Scope and limitations and application to the synthesis of glycodipeptides Journal of Organic Chemistry. 74: 3886-3893. PMID 19385609 DOI: 10.1021/Jo900532E  0.513
2009 Bowers AA, West N, Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O, Bradner JE, Williams RM. Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold. Organic Letters. 11: 1301-4. PMID 19239241 DOI: 10.1021/Ol900078K  0.743
2009 Bowers AA, Greshock TJ, West N, Estiu G, Schreiber SL, Wiest O, Williams RM, Bradner JE. Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole. Journal of the American Chemical Society. 131: 2900-5. PMID 19193120 DOI: 10.1021/Ja807772W  0.603
2009 Li Z, Hu M, Leung C, Steinberg JA, Shen J, Li M, Wang CS, Sanchez E, Bowers A, Greshock T, Miller K, Newkirk T, West N, Bradner JE, Williams RM, et al. Largazole, a Novel Cyclic Peptide Histone Deacetylase Inhibitor, Demonstrates Anti-MM Effects Alone and Increases the Anti-MM Effects of Bortezomib. Blood. 114: 4925-4925. DOI: 10.1182/Blood.V114.22.4925.4925  0.73
2009 Cao H, Fei RG, Bowers AA, Greshock TJ, Newkirt T, Miller KA, Bradner JE, West N, Williams RM, Papayannopoulou T, Stamatoyannopoulos G. Potent Induction of Human γ Globin Gene Expression by Largazole, a New Histone Deacetylase Inhibitor. Blood. 114: 2022-2022. DOI: 10.1182/Blood.V114.22.2022.2022  0.679
2008 Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. Journal of the American Chemical Society. 130: 11219-22. PMID 18642817 DOI: 10.1021/Ja8033763  0.599
2008 Zhong W, Boons GJ, Crich D, Bowers AA. Glycoside Synthesis from 1-Sulfur/Selenium-Substituted Derivatives: Sulfoxides, Sulfimides and Sulfones Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance. 303-329. DOI: 10.1002/9783527621644.ch4b  0.424
2008 Zhong W, Boons GJ, Crich D, Bowers AA. Glycoside Synthesis from 1-Sulfur/Selenium-Substituted Derivatives: Thioglycosides in Oligosaccharide Synthesis Handbook of Chemical Glycosylation: Advances in Stereoselectivity and Therapeutic Relevance. 261-303. DOI: 10.1002/9783527621644.ch4a  0.428
2007 Crich D, Bowers AA. Cyclic thioanhydrides: Linchpins for multicomponent coupling reactions based on the reaction of thioacids with electron-deficient sulfonamides and azides Organic Letters. 9: 5323-5325. PMID 17979281 DOI: 10.1021/Ol702570X  0.474
2007 Crich D, Grant D, Bowers AA. Heterobivalent library expansion by "living radical" processes: thiocarbonyl addition/elimination, and nitroxide-based reactions with fluorous deconvolution. Journal of the American Chemical Society. 129: 12106-7. PMID 17880090 DOI: 10.1021/Ja0756321  0.588
2007 Nokami T, Shibuya A, Tsuyama H, Suga S, Bowers AA, Crich D, Yoshida JI. Electrochemical generation of glycosyl triflate pools Journal of the American Chemical Society. 129: 10922-10928. PMID 17696345 DOI: 10.1021/Ja072440X  0.423
2007 Crich D, Pedersen CM, Bowers AA, Wink DJ. On the use of 3,5-O-benzylidene and 3,5-O-(di-tert-butylsilylene)-2-O-benzylarabinothiofuranosides and their sulfoxides as glycosyl donors for the synthesis of beta-arabinofuranosides: importance of the activation method. The Journal of Organic Chemistry. 72: 1553-65. PMID 17286432 DOI: 10.1021/Jo061440X  0.523
2006 Crich D, Bowers AA. Synthesis of a beta-(1-->3)-D-rhamnotetraose by a one-pot, multiple radical fragmentation. Organic Letters. 8: 4327-30. PMID 16956218 DOI: 10.1021/Ol061706M  0.431
2006 Crich D, Bowers AA. 4,6-O-[1-cyano-2-(2-iodophenyl)ethylidene] acetals. improved second-generation acetals for the stereoselective formation of beta-D-mannopyranosides and regioselective reductive radical fragmentation to beta-D-rhamnopyranosides. scope and limitations. The Journal of Organic Chemistry. 71: 3452-63. PMID 16626126 DOI: 10.1021/Jo0526688  0.473
2006 Crich D, Yao Q, Bowers AA. On the regioselectivity of the Hanessian-Hullar reaction in 4,6-O-benzylidene protected galactopyranosides. Carbohydrate Research. 341: 1748-52. PMID 16530738 DOI: 10.1016/J.Carres.2006.02.024  0.601
1967 Crabbé P, Bowers A. Steroids. CCCV. Synthesis of 11-hydroxy-1-methyl-19-norretrotestosterone Journal of Organic Chemistry. 32: 2921-2924. PMID 6073223 DOI: 10.1021/Jo01284A071  0.31
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