Diana M. Downs - Publications

Affiliations: 
University of Wisconsin, Madison, Madison, WI 
Area:
Microbiology Biology

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Borchert AJ, Walejko JM, Guennec AL, Ernst DC, Edison AS, Downs DM. Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in . Metabolites. 10. PMID 31878179 DOI: 10.3390/Metabo10010012  0.52
2019 Borchert AJ, Ernst DC, Downs DM. Reactive Enamines and Imines In Vivo: Lessons from the RidA Paradigm. Trends in Biochemical Sciences. PMID 31103411 DOI: 10.1016/J.Tibs.2019.04.011  0.52
2018 Downs DM, Bazurto JV, Gupta A, Fonseca LL, Voit EO. The three-legged stool of understanding metabolism: integrating metabolomics with biochemical genetics and computational modeling. Aims Microbiology. 4: 289-303. PMID 31294216 DOI: 10.3934/microbiol.2018.2.289  1
2018 Ernst DC, Borchert AJ, Downs DM. Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways. Plos One. 13: e0197703. PMID 29791499 DOI: 10.1371/Journal.Pone.0197703  0.52
2018 Ernst DC, Downs DM. Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in. Mbio. 9. PMID 29487232 DOI: 10.1128/Mbio.00084-18  0.52
2018 Ernst DC, Christopherson MR, Downs DM. Increased activity of cystathionine β-lyase suppresses 2-aminoacrylate stress in. Journal of Bacteriology. PMID 29440255 DOI: 10.1128/Jb.00040-18  0.96
2017 Bazurto JV, Dearth SP, Tague ED, Campagna SR, Downs DM. Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica. Microbial Cell (Graz, Austria). 5: 74-87. PMID 29417056 DOI: 10.15698/Mic2018.02.613  1
2016 Bazurto JV, Downs DM. Metabolic network structure and function in bacteria goes beyond conserved enzyme components. Microbial Cell (Graz, Austria). 3: 260-262. PMID 28357363 DOI: 10.15698/Mic2016.06.509  1
2016 Ernst DC, Anderson ME, Downs DM. L-2,3-diaminopropionate generates diverse metabolic stresses in Salmonella enterica. Molecular Microbiology. PMID 27010356 DOI: 10.1111/Mmi.13384  1
2016 Bazurto JV, Farley KR, Downs DM. An Unexpected Route to an Essential Cofactor: Escherichia coli Relies on Threonine for Thiamine Biosynthesis. Mbio. 7. PMID 26733068 DOI: 10.1128/Mbio.01840-15  1
2015 Ernst DC, Downs DM. 2-Aminoacrylate Stress Induces a Context-Dependent Glycine Requirement in ridA Strains of Salmonella enterica. Journal of Bacteriology. 198: 536-43. PMID 26574511 DOI: 10.1128/Jb.00804-15  1
2015 Palmer LD, Paxhia MD, Downs DM. Induction of the Sugar-Phosphate Stress Response Allows Saccharomyces cerevisiae 2-Methyl-4-Amino-5-Hydroxymethylpyrimidine Phosphate Synthase To Function in Salmonella enterica. Journal of Bacteriology. 197: 3554-62. PMID 26324451 DOI: 10.1128/Jb.00576-15  1
2015 Bazurto JV, Heitman NJ, Downs DM. Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica. Journal of Bacteriology. 197: 2821-30. PMID 26100042 DOI: 10.1128/Jb.00282-15  1
2015 Niehaus TD, Gerdes S, Hodge-Hanson K, Zhukov A, Cooper AJ, ElBadawi-Sidhu M, Fiehn O, Downs DM, Hanson AD. Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family. Bmc Genomics. 16: 382. PMID 25975565 DOI: 10.1186/S12864-015-1584-3  1
2015 Ernst DC, Downs DM. The STM4195 gene product (PanS) transports coenzyme A precursors in Salmonella enterica. Journal of Bacteriology. 197: 1368-77. PMID 25645561 DOI: 10.1128/Jb.02506-14  0.52
2015 Downs DM, Ernst DC. From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species. Molecular Microbiology. 96: 211-9. PMID 25620221 DOI: 10.1111/Mmi.12945  1
2014 Palmer LD, Leung MH, Downs DM. The cysteine desulfhydrase CdsH is conditionally required for sulfur mobilization to the thiamine thiazole in Salmonella enterica. Journal of Bacteriology. 196: 3964-70. PMID 25182497 DOI: 10.1128/Jb.02159-14  1
2014 Niehaus TD, Nguyen TN, Gidda SK, ElBadawi-Sidhu M, Lambrecht JA, McCarty DR, Downs DM, Cooper AJ, Fiehn O, Mullen RT, Hanson AD. Arabidopsis and maize RidA proteins preempt reactive enamine/imine damage to branched-chain amino acid biosynthesis in plastids. The Plant Cell. 26: 3010-22. PMID 25070638 DOI: 10.1105/Tpc.114.126854  1
2014 Ernst DC, Lambrecht JA, Schomer RA, Downs DM. Endogenous synthesis of 2-aminoacrylate contributes to cysteine sensitivity in Salmonella enterica. Journal of Bacteriology. 196: 3335-42. PMID 25002544 DOI: 10.1128/Jb.01960-14  1
2014 Bazurto JV, Downs DM. Amino-4-imidazolecarboxamide ribotide directly inhibits coenzyme A biosynthesis in Salmonella enterica. Journal of Bacteriology. 196: 772-9. PMID 24296672 DOI: 10.1128/Jb.01087-13  1
2013 Palmer LD, Downs DM. The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites. The Journal of Biological Chemistry. 288: 30693-9. PMID 24014032 DOI: 10.1074/Jbc.M113.500280  1
2013 Flynn JM, Christopherson MR, Downs DM. Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase. Molecular Microbiology. 89: 751-9. PMID 23815688 DOI: 10.1111/Mmi.12313  1
2013 Flynn JM, Downs DM. In the absence of RidA, endogenous 2-aminoacrylate inactivates alanine racemases by modifying the pyridoxal 5'-phosphate cofactor. Journal of Bacteriology. 195: 3603-9. PMID 23749972 DOI: 10.1128/Jb.00463-13  1
2013 Lambrecht JA, Schmitz GE, Downs DM. RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life. Mbio. 4: e00033-13. PMID 23386433 DOI: 10.1128/Mbio.00033-13  1
2013 Lambrecht JA, Downs DM. Anthranilate phosphoribosyl transferase (TrpD) generates phosphoribosylamine for thiamine synthesis from enamines and phosphoribosyl pyrophosphate. Acs Chemical Biology. 8: 242-8. PMID 23101964 DOI: 10.1021/Cb300364K  1
2012 Koenigsknecht MJ, Lambrecht JA, Fenlon LA, Downs DM. Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica. Plos One. 7: e48207. PMID 23133571 DOI: 10.1371/Journal.Pone.0048207  1
2012 Palmer LD, Dougherty MJ, Downs DM. Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica. Journal of Bacteriology. 194: 6088-95. PMID 22961850 DOI: 10.1128/Jb.01361-12  1
2012 Christopherson MR, Lambrecht JA, Downs D, Downs DM. Suppressor analyses identify threonine as a modulator of ridA mutant phenotypes in Salmonella enterica. Plos One. 7: e43082. PMID 22900093 DOI: 10.1371/Journal.Pone.0043082  1
2012 Boyd JM, Teoh WP, Downs DM. Decreased transport restores growth of a Salmonella enterica apbC mutant on tricarballylate. Journal of Bacteriology. 194: 576-83. PMID 22101844 DOI: 10.1128/Jb.05988-11  1
2012 Lambrecht JA, Flynn JM, Downs DM. Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions. The Journal of Biological Chemistry. 287: 3454-61. PMID 22094463 DOI: 10.1074/Jbc.M111.304477  1
2011 Martinez-Gomez NC, Palmer LD, Vivas E, Roach PL, Downs DM. The rhodanese domain of ThiI is both necessary and sufficient for synthesis of the thiazole moiety of thiamine in Salmonella enterica. Journal of Bacteriology. 193: 4582-7. PMID 21724998 DOI: 10.1128/Jb.05325-11  1
2011 Boyd JM, Endrizzi JA, Hamilton TL, Christopherson MR, Mulder DW, Downs DM, Peters JW. FAD binding by ApbE protein from Salmonella enterica: a new class of FAD-binding proteins. Journal of Bacteriology. 193: 887-95. PMID 21148731 DOI: 10.1128/Jb.00730-10  1
2011 Bazurto JV, Downs DM. Plasticity in the purine-thiamine metabolic network of Salmonella. Genetics. 187: 623-31. PMID 21135073 DOI: 10.1534/Genetics.110.124362  1
2010 Lambrecht JA, Browne BA, Downs DM. Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro. The Journal of Biological Chemistry. 285: 34401-7. PMID 20817725 DOI: 10.1074/Jbc.M110.160515  1
2010 Koenigsknecht MJ, Downs DM. Thiamine biosynthesis can be used to dissect metabolic integration. Trends in Microbiology. 18: 240-7. PMID 20382023 DOI: 10.1016/J.Tim.2010.03.003  1
2010 Koenigsknecht MJ, Fenlon LA, Downs DM. Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica. Microbiology (Reading, England). 156: 950-9. PMID 19959576 DOI: 10.1099/Mic.0.033050-0  1
2009 Lewis JA, Boyd JM, Downs DM, Escalante-Semerena JC. Involvement of the Cra global regulatory protein in the expression of the iscRSUA operon, revealed during studies of tricarballylate catabolism in Salmonella enterica. Journal of Bacteriology. 191: 2069-76. PMID 19136587 DOI: 10.1128/Jb.01577-08  1
2009 Thorgersen MP, Downs DM. Oxidative stress and disruption of labile iron generate specific auxotrophic requirements in Salmonella enterica. Microbiology (Reading, England). 155: 295-304. PMID 19118370 DOI: 10.1099/Mic.0.020727-0  1
2009 Boyd JM, Drevland RM, Downs DM, Graham DE. Archaeal ApbC/Nbp35 homologs function as iron-sulfur cluster carrier proteins. Journal of Bacteriology. 191: 1490-7. PMID 19114487 DOI: 10.1128/Jb.01469-08  1
2009 Martinez-Gomez NC, Poyner RR, Mansoorabadi SO, Reed GH, Downs DM. Reaction of AdoMet with ThiC generates a backbone free radical. Biochemistry. 48: 217-9. PMID 19113839 DOI: 10.1021/Bi802154J  1
2009 Boyd JM, Sondelski JL, Downs DM. Bacterial ApbC protein has two biochemical activities that are required for in vivo function. The Journal of Biological Chemistry. 284: 110-8. PMID 19001370 DOI: 10.1074/Jbc.M807003200  1
2008 Thorgersen MP, Downs DM. Analysis of yggX and gshA mutants provides insights into the labile iron pool in Salmonella enterica. Journal of Bacteriology. 190: 7608-13. PMID 18835989 DOI: 10.1128/Jb.00639-08  1
2008 Martinez-Gomez NC, Downs DM. ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis. Biochemistry. 47: 9054-6. PMID 18686975 DOI: 10.1021/Bi8010253  1
2008 Boyd JM, Pierik AJ, Netz DJ, Lill R, Downs DM. Bacterial ApbC can bind and effectively transfer iron-sulfur clusters. Biochemistry. 47: 8195-202. PMID 18616280 DOI: 10.1021/Bi800551Y  1
2008 Boyd JM, Lewis JA, Escalante-Semerena JC, Downs DM. Salmonella enterica requires ApbC function for growth on tricarballylate: evidence of functional redundancy between ApbC and IscU. Journal of Bacteriology. 190: 4596-602. PMID 18441067 DOI: 10.1128/Jb.00262-08  1
2008 Christopherson MR, Schmitz GE, Downs DM. YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium. Journal of Bacteriology. 190: 3057-62. PMID 18296521 DOI: 10.1128/Jb.01700-07  1
2008 Bender RA, Downs D, Kiley P, LaRossa RA, Sonenshein AL, Storz G, Bender R, Roth J, Schilling C, Rine's J, Merrick M, Tyson G, Skovran E, Liao J, Stephanopolous' G, et al. Bridges cnd Chasms: Summary of the IMAGE 2 meeting in Montreal, Canada, 30 April to 3 May 2007 Journal of Bacteriology. 190: 792-797. PMID 17827302 DOI: 10.1128/Jb.01097-07  1
2008 Ramos I, Vivas EI, Downs DM. Mutations in the tryptophan operon allow purF-independent thiamine synthesis by altering flux in vivo Journal of Bacteriology. 190: 815-822. PMID 17557816 DOI: 10.1128/Jb.00582-07  1
2007 Thorgersen MP, Downs DM. Cobalt targets multiple metabolic processes in Salmonella enterica. Journal of Bacteriology. 189: 7774-81. PMID 17720790 DOI: 10.1128/Jb.00962-07  1
2007 Koenigsknecht MJ, Ramos I, Downs DM. Glutamine phosphoribosylpyrophosphate amidotransferase-independent phosphoribosyl amine synthesis from ribose 5-phosphate and glutamine or asparagine. The Journal of Biological Chemistry. 282: 28379-84. PMID 17686772 DOI: 10.1074/Jbc.M704024200  1
2006 Dougherty MJ, Boyd JM, Downs DM. Inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of Salmonella enterica purH mutants on glycerol. The Journal of Biological Chemistry. 281: 33892-9. PMID 16987812 DOI: 10.1074/Jbc.M604429200  1
2006 Browne BA, Ramos AI, Downs DM. PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase. Journal of Bacteriology. 188: 6786-92. PMID 16980480 DOI: 10.1128/Jb.00745-06  1
2006 Dougherty MJ, Downs DM. A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica. Microbiology (Reading, England). 152: 2345-53. PMID 16849799 DOI: 10.1099/Mic.0.28926-0  1
2006 Downs DM. Understanding microbial metabolism. Annual Review of Microbiology. 60: 533-59. PMID 16771650 DOI: 10.1146/Annurev.Micro.60.080805.142308  1
2006 Schmitz GE, Downs DM. An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source. Journal of Bacteriology. 188: 3126-9. PMID 16585773 DOI: 10.1128/Jb.188.8.3126-3129.2006  1
2006 Vivas E, Skovran E, Downs DM. Salmonella enterica strains lacking the frataxin homolog cyaY show defects in Fe-S cluster metabolism in vivo Journal of Bacteriology. 188: 1175-1179. PMID 16428423 DOI: 10.1128/Jb.188.3.1175-1179.2006  1
2006 Cui Q, Thorgersen MP, Westler WM, Markley JL, Downs DM. Solution structure of YggX: a prokaryotic protein involved in Fe(II) trafficking. Proteins. 62: 578-86. PMID 16329120 DOI: 10.1002/Prot.20781  1
2005 Downs DM, Schmitz GE, Skovran E. Probing the complex system of metabolic integration. Progress in Nucleic Acid Research and Molecular Biology. 80: 43-94. PMID 16164972 DOI: 10.1016/S0079-6603(05)80002-9  1
2004 Skovran E, Lauhon CT, Downs DM. Lack of YggX results in chronic oxidative stress and uncovers subtle defects in Fe-S cluster metabolism in Salmonella enterica Journal of Bacteriology. 186: 7626-7634. PMID 15516576 DOI: 10.1128/Jb.186.22.7626-7634.2004  1
2004 Zhang Y, Dougherty M, Downs DM, Ealick SE. Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily. Structure (London, England : 1993). 12: 1809-21. PMID 15458630 DOI: 10.1016/J.Str.2004.07.020  1
2004 Martinez-Gomez NC, Robers M, Downs DM. Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily. The Journal of Biological Chemistry. 279: 40505-10. PMID 15271986 DOI: 10.1074/Jbc.M403985200  1
2004 Dougherty MJ, Downs DM. A mutant allele of rpoD results in increased conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine in Salmonella enterica. Journal of Bacteriology. 186: 4034-7. PMID 15175319 DOI: 10.1128/Jb.186.12.4034-4037.2004  1
2004 Lauhon CT, Skovran E, Urbina HD, Downs DM, Vickery LE. Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. The Journal of Biological Chemistry. 279: 19551-8. PMID 14978044 DOI: 10.1074/Jbc.M401261200  1
2004 Schmitz G, Downs DM. Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium. Journal of Bacteriology. 186: 803-10. PMID 14729707 DOI: 10.1128/Jb.186.3.803-810.2004  1
2003 Beck BJ, Huelsmeyer M, Paul S, Downs DM. A Mutation in the Essential Gene gmk (Encoding Guanlyate Kinase) Generates a Requirement for Adenine at Low Temperature in Salmonella enterica Journal of Bacteriology. 185: 6732-6735. PMID 14594851 DOI: 10.1128/Jb.185.22.6732-6735.2003  1
2003 Ramos I, Downs DM. Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica. Journal of Bacteriology. 185: 5125-32. PMID 12923085 DOI: 10.1128/Jb.185.17.5125-5132.2003  1
2003 Gralnick JA, Downs DM. The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. The Journal of Biological Chemistry. 278: 20708-15. PMID 12670952 DOI: 10.1074/Jbc.M301577200  1
2003 Downs DM. Genomics and bacterial metabolism. Current Issues in Molecular Biology. 5: 17-25. PMID 12638661  1
2003 Dougherty M, Downs DM. The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains. Journal of Bacteriology. 185: 332-9. PMID 12486071 DOI: 10.1128/Jb.185.1.332-339.2003  1
2003 Skovran E, Downs DM. Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium. Journal of Bacteriology. 185: 98-106. PMID 12486045 DOI: 10.1128/Jb.185.1.98-106.2003  1
2002 Allen S, Zilles JL, Downs DM. Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella enterica. Journal of Bacteriology. 184: 6130-7. PMID 12399482 DOI: 10.1128/Jb.184.22.6130-6137.2002  1
2002 Rubio A, Downs DM. Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme a elevation in Salmonella enterica serovar typhimurium Journal of Bacteriology. 184: 2827-2832. PMID 11976313 DOI: 10.1128/Jb.184.10.2827-2832.2002  1
2001 Zilles JL, Kappock TJ, Stubbe J, Downs DM. Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase. Journal of Bacteriology. 183: 2234-40. PMID 11244062 DOI: 10.1128/Jb.183.7.2234-2240.2001  1
2000 Zilles JL, Croal LR, Downs DM. Action of the thiamine protagonist bacimethrin on thiamine biosynthesis Journal of Bacteriology. 182: 5606-5610. PMID 10986269 DOI: 10.1128/Jb.182.19.5606-5610.2000  1
2000 Skovran E, Downs DM. Metabolic defects caused by mutations in the isc gene cluster in Salmonella enterica serovar typhimurium: Implications for thiamine synthesis Journal of Bacteriology. 182: 3896-3903. PMID 10869064 DOI: 10.1128/Jb.182.14.3896-3903.2000  1
2000 Frodyma M, Rubio A, Downs DM. Reduced flux through the purine biosynthetic pathway results in an increased requirement for coenzyme A in thiamine synthesis in Salmonella enterica serovar Typhimurium Journal of Bacteriology. 182: 236-240. PMID 10613889 DOI: 10.1128/Jb.182.1.236-240.2000  1
2000 Claas K, Weber S, Downs DM. Lesions in the nuo operon, encoding NADH dehydrogenase complex I, prevent PurF-independent thiamine synthesis and reduce flux through the oxidative pentose phosphate pathway in Salmonella enterica serovar typhimurium Journal of Bacteriology. 182: 228-232. PMID 10613887 DOI: 10.1128/Jb.182.1.228-232.2000  1
2000 Downs DM, Escalante-Semerena JC. Impact of genomics and genetics on the elucidation of bacterial metabolism Methods. 20: 47-54. PMID 10610803 DOI: 10.1006/Meth.1999.0904  1
1999 Beck BJ, Downs DM. A periplasmic location is essential for the role of the ApbE lipoprotein in thiamine synthesis in Salmonella typhimurium Journal of Bacteriology. 181: 7285-7290. PMID 10572132 DOI: 10.1128/Jb.181.23.7285-7290.1999  1
1999 Christian T, Downs DM. Defects in pyruvate kinase cause a conditional increase of thiamine synthesis in Salmonella typhimurium. Canadian Journal of Microbiology. 45: 565-72. PMID 10497788 DOI: 10.1139/W99-042  1
1999 Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J. Thiamin biosynthesis in prokaryotes. Archives of Microbiology. 171: 293-300. PMID 10382260 DOI: 10.1007/S002030050713  1
1999 Enos-Berlage JL, Downs DM. Biosynthesis of the pyrimidine moiety of thiamine independent of the PurF enzyme (phosphoribosylpyrophosphate amidotransferase) in Salmonella typhimurium: Incorporation of stable isotope-labeled glycine and formate Journal of Bacteriology. 181: 841-848. PMID 9922247 DOI: 10.1128/Jb.181.3.841-848.1999  1
1998 Enos-Berlage JL, Langendorf MJ, Downs DM. Complex metabolic phenotypes caused by a mutation in yjgF, encoding a member of the highly conserved YER057c/YjgF family of proteins Journal of Bacteriology. 180: 6519-6528. PMID 9851994 DOI: 10.1128/Jb.180.24.6519-6528.1998  1
1998 Kim YS, Nosaka K, Downs DM, Kwak JM, Park D, Chung IK, Nam HG. A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase involved in thiamin biosynthesis. Plant Molecular Biology. 37: 955-66. PMID 9700068 DOI: 10.1023/A:1006030617502  1
1998 Beck BJ, Downs DM. The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium Journal of Bacteriology. 180: 885-891. PMID 9473043 DOI: 10.1128/Jb.180.4.885-891.1998  1
1998 Reddick JJ, Kinsland C, Nicewonger R, Christian T, Downs DM, Winkler ME, Begley TP. Overexpression, purification and characterization of two pyrimidine kinases involved in the biosynthesis of thiamin: 4-amino-5-hydroxymethyl-2- methylpyrimidine kinase and 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase Tetrahedron. 54: 15983-15991. DOI: 10.1016/S0040-4020(98)01006-0  1
1997 Beck BJ, Connolly LE, De las Penas A, Downs DM. Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium Journal of Bacteriology. 179: 6504-6508. PMID 9335303 DOI: 10.1128/Jb.179.20.6504-6508.1997  1
1997 Petersen LA, Downs DM. Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis Journal of Bacteriology. 179: 4894-4900. PMID 9244280 DOI: 10.1128/Jb.179.15.4894-4900.1997  1
1997 Webb E, Claas K, Downs DM. Characterization of thiI, a new gene involved in thiazole biosynthesis in Salmonella typhimurium Journal of Bacteriology. 179: 4399-4402. PMID 9209060 DOI: 10.1128/Jb.179.13.4399-4402.1997  1
1997 Enos-Berlage JL, Downs DM. Mutations in sdh (succinate dehydrogenase genes) alter the thiamine requirement of Salmonella typhimurium Journal of Bacteriology. 179: 3989-3996. PMID 9190816 DOI: 10.1128/Jb.179.12.3989-3996.1997  1
1996 Zilles JL, Downs DM. A novel involvement of the PurG and PurI proteins in thiamine synthesis via the alternative pyrimidine biosynthetic (APB) pathway in Salmonella typhimurium Genetics. 144: 883-892. PMID 8913735  1
1996 Petersen L, Downs DM. Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium Journal of Bacteriology. 178: 5676-5682. PMID 8824612 DOI: 10.1128/Jb.178.19.5676-5682.1996  1
1996 Petersen L, Enos-Berlage J, Downs DM. Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium Genetics. 143: 37-44. PMID 8722760  1
1996 Enos-Berlage JL, Downs DM. Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium Journal of Bacteriology. 178: 1476-1479. PMID 8631729 DOI: 10.1128/Jb.178.5.1476-1479.1996  1
1996 Webb E, Febres F, Downs DM. Thiamine pyrophosphate (TPP) negatively regulates transcription of some thi genes of Salmonella typhimurium Journal of Bacteriology. 178: 2533-2538. PMID 8626319 DOI: 10.1128/Jb.178.9.2533-2538.1996  1
1994 Downs DM, Petersen L. apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium Journal of Bacteriology. 176: 4858-4864. PMID 7519593 DOI: 10.1128/Jb.176.16.4858-4864.1994  1
1993 Downs DM, Ludden PW, Shah VK. Accumulation of factor F395 in nifNE mutants of Klebsiella pneumoniae Canadian Journal of Microbiology. 39: 351-354. PMID 8477353 DOI: 10.1139/M93-050  1
1992 Downs DM. Evidence for a new, oxygen-regulated biosynthetic pathway for the pyrimidine moiety of thiamine in Salmonella typhimurium Journal of Bacteriology. 174: 1515-1521. PMID 1537796 DOI: 10.1128/Jb.174.5.1515-1521.1992  1
1991 Downs DM, Roth JR. Synthesis of thiamine in Salmonella typhimurium independent of the purF function Journal of Bacteriology. 173: 6597-6604. PMID 1917881  1
1990 Downs DM, Ludden PW, Shah VK. Synthesis of the iron-molybdenum cofactor of nitrogenase is inhibited by a low-molecular-weight metabolite of Klebsiella pneumoniae Journal of Bacteriology. 172: 6084-6089. PMID 2211526 DOI: 10.1128/Jb.172.10.6084-6089.1990  1
1987 Downs DM, Roth JR. A novel P22 prophage in Salmonella typhimurium Genetics. 117: 367-380. PMID 3319766  1
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