| Year |
Citation |
Score |
| 2023 |
Fulton RL, Downs DM. Modulators of a robust and efficient metabolism: Perspective and insights from the Rid superfamily of proteins. Advances in Microbial Physiology. 83: 117-179. PMID 37507158 DOI: 10.1016/bs.ampbs.2023.04.001 |
0.358 |
|
| 2022 |
Fulton RL, Downs DM. DadY (PA5303) is required for fitness of when growth is dependent on alanine catabolism. Microbial Cell (Graz, Austria). 9: 190-201. PMID 36483308 DOI: 10.15698/mic2022.12.788 |
0.334 |
|
| 2022 |
Fulton RL, Irons J, Downs DM. The Cysteine Desulfurase IscS Is a Significant Target of 2-Aminoacrylate Damage in Pseudomonas aeruginosa. Mbio. e0107122. PMID 35652590 DOI: 10.1128/mbio.01071-22 |
0.407 |
|
| 2022 |
Shen W, Borchert AJ, Downs DM. 2-Aminoacrylate stress damages diverse PLP-dependent enzymes in vivo. The Journal of Biological Chemistry. 298: 101970. PMID 35460692 DOI: 10.1016/j.jbc.2022.101970 |
0.311 |
|
| 2022 |
Vu HN, Downs DM. Genetic analysis using vitamin B antagonist 4-deoxypyridoxine uncovers a connection between pyridoxal 5'-phosphate and coenzyme A metabolism in . Journal of Bacteriology. jb0060721. PMID 35099985 DOI: 10.1128/jb.00607-21 |
0.322 |
|
| 2022 |
Ito T, Ogawa H, Hemmi H, Downs DM, Yoshimura T. Mechanism of pyridoxine 5'-phosphate accumulation in PLPBP protein-deficiency. Journal of Bacteriology. JB0052121. PMID 34978460 DOI: 10.1128/JB.00521-21 |
0.398 |
|
| 2021 |
Paxhia MD, Downs DM. Pyridoxal and α-ketoglutarate independently improve function of Thi5 in the metabolic network of . Journal of Bacteriology. JB0045021. PMID 34662241 DOI: 10.1128/JB.00450-21 |
0.31 |
|
| 2021 |
Whitaker GH, Ernst DC, Downs DM. Absence of MMF1 disrupts heme biosynthesis by targeting Hem1pin Saccharomyces cerevisiae. Yeast (Chichester, England). PMID 34559917 DOI: 10.1002/yea.3670 |
0.318 |
|
| 2021 |
Vu HN, Downs DM. Loss of YggS (COG0325) impacts aspartate metabolism in Salmonella enterica. Molecular Microbiology. PMID 34498310 DOI: 10.1111/mmi.14810 |
0.404 |
|
| 2021 |
Buckner BA, Lato AM, Campagna SR, Downs DM. The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase. The Journal of Biological Chemistry. 100651. PMID 33839153 DOI: 10.1016/j.jbc.2021.100651 |
0.362 |
|
| 2020 |
Vu HN, Downs DM. An Unexpected Role for the Periplasmic Phosphatase PhoN in the Salvage of B Vitamers in . Applied and Environmental Microbiology. PMID 33218995 DOI: 10.1128/AEM.02300-20 |
0.306 |
|
| 2020 |
Vu HN, Ito T, Downs DM. The role of YggS in vitamin B homeostasis in is informed by heterologous expression of yeast . Journal of Bacteriology. PMID 32900833 DOI: 10.1128/Jb.00383-20 |
0.484 |
|
| 2020 |
Irons JL, Hodge-Hanson K, Downs DM. RidA Proteins Protect against Metabolic Damage by Reactive Intermediates. Microbiology and Molecular Biology Reviews : Mmbr. 84. PMID 32669283 DOI: 10.1128/Mmbr.00024-20 |
0.513 |
|
| 2020 |
Digiovanni S, Visentin C, Degani G, Barbiroli A, Chiara M, Regazzoni L, Di Pisa F, Borchert AJ, Downs DM, Ricagno S, Vanoni MA, Popolo L. Two novel fish paralogs provide insights into the Rid family of imine deaminases active in pre-empting enamine/imine metabolic damage. Scientific Reports. 10: 10135. PMID 32576850 DOI: 10.1038/S41598-020-66663-W |
0.451 |
|
| 2020 |
Ito T, Downs DM. Pyridoxal reductase, PdxI, is critical for salvage of pyridoxal in . Journal of Bacteriology. PMID 32253339 DOI: 10.1128/Jb.00056-20 |
0.473 |
|
| 2020 |
Martínez-Chavarría LC, Sagawa J, Irons J, Hinz AK, Lemon A, Graça T, Downs DM, Vadyvaloo V. Putative horizontally acquired genes, highly transcribed during flea infection, are induced by hyperosmotic stress and function in aromatic amino acid metabolism. Journal of Bacteriology. PMID 32205462 DOI: 10.1128/Jb.00733-19 |
0.388 |
|
| 2020 |
Borchert AJ, Gouveia GJ, Edison AS, Downs DM. Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a Mutant of Salmonella enterica. Msystems. 5. PMID 32156800 DOI: 10.1128/mSystems.00843-19 |
0.384 |
|
| 2019 |
Borchert AJ, Walejko JM, Guennec AL, Ernst DC, Edison AS, Downs DM. Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in . Metabolites. 10. PMID 31878179 DOI: 10.3390/Metabo10010012 |
0.451 |
|
| 2019 |
Downs DM. Balancing cost and benefit: How E. coli cleverly averts disulfide stress caused by cystine. Molecular Microbiology. PMID 31710395 DOI: 10.1111/Mmi.14422 |
0.412 |
|
| 2019 |
Ito T, Hori R, Hemmi H, Downs DM, Yoshimura T. Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli. Molecular Microbiology. PMID 31677193 DOI: 10.1111/Mmi.14415 |
0.494 |
|
| 2019 |
Irons J, Sacher JC, Szymanski CM, Downs DM. Cj1388 Is a RidA Homolog and Is Required for Flagella Biosynthesis and/or Function in . Frontiers in Microbiology. 10: 2058. PMID 31555246 DOI: 10.3389/Fmicb.2019.02058 |
0.43 |
|
| 2019 |
Borchert AJ, Ernst DC, Downs DM. Reactive Enamines and Imines In Vivo: Lessons from the RidA Paradigm. Trends in Biochemical Sciences. PMID 31103411 DOI: 10.1016/J.Tibs.2019.04.011 |
0.438 |
|
| 2019 |
Ito T, Yamamoto K, Hori R, Yamauchi A, Downs DM, Hemmi H, Yoshimura T. Conserved Pyridoxal 5'-Phosphate Binding Protein YggS Impacts Amino Acid Metabolism through Pyridoxine 5'-Phosphate in . Applied and Environmental Microbiology. PMID 30902856 DOI: 10.1128/Aem.00430-19 |
0.491 |
|
| 2018 |
Downs DM, Bazurto JV, Gupta A, Fonseca LL, Voit EO. The three-legged stool of understanding metabolism: integrating metabolomics with biochemical genetics and computational modeling. Aims Microbiology. 4: 289-303. PMID 31294216 DOI: 10.3934/microbiol.2018.2.289 |
0.787 |
|
| 2018 |
Paxhia MD, Downs DM. Encodes a PLP Synthase Involved in Thiamine Synthesis in . G3 (Bethesda, Md.). PMID 30498136 DOI: 10.1534/G3.118.200831 |
0.44 |
|
| 2018 |
Borchert AJ, Downs DM. Analyses of variants of the Ser/Thr dehydratase IlvA provide insight into 2-aminoacrylate metabolism in Salmonella enterica. The Journal of Biological Chemistry. PMID 30327426 DOI: 10.1074/Jbc.Ra118.005626 |
0.527 |
|
| 2018 |
Irons J, Hodge-Hanson KM, Downs DM. PA5339, a RidA homolog, is required for full growth in . Journal of Bacteriology. PMID 30181125 DOI: 10.1128/Jb.00434-18 |
0.526 |
|
| 2018 |
Ernst DC, Borchert AJ, Downs DM. Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways. Plos One. 13: e0197703. PMID 29791499 DOI: 10.1371/Journal.Pone.0197703 |
0.497 |
|
| 2018 |
Ernst DC, Downs DM. Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in. Mbio. 9. PMID 29487232 DOI: 10.1128/Mbio.00084-18 |
0.383 |
|
| 2018 |
Ernst DC, Christopherson MR, Downs DM. Increased activity of cystathionine β-lyase suppresses 2-aminoacrylate stress in. Journal of Bacteriology. PMID 29440255 DOI: 10.1128/Jb.00040-18 |
0.801 |
|
| 2018 |
Hodge-Hanson KM, Zoino A, Downs DM. Expression of PLP-independent racemases can reduce 2-aminoacrylate stress in. Journal of Bacteriology. PMID 29440254 DOI: 10.1128/Jb.00751-17 |
0.51 |
|
| 2017 |
Bazurto JV, Dearth SP, Tague ED, Campagna SR, Downs DM. Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica. Microbial Cell (Graz, Austria). 5: 74-87. PMID 29417056 DOI: 10.15698/Mic2018.02.613 |
0.834 |
|
| 2017 |
Borchert AJ, Downs DM. Endogenously generated 2-aminoacrylate inhibits motility in Salmonella enterica. Scientific Reports. 7: 12971. PMID 29021529 DOI: 10.1038/S41598-017-13030-X |
0.553 |
|
| 2017 |
Hodge-Hanson KM, Downs DM. Members of the Rid protein family have broad imine deaminase activity and can accelerate the Pseudomonas aeruginosa D-arginine dehydrogenase (DauA) reaction in vitro. Plos One. 12: e0185544. PMID 28957411 DOI: 10.1371/Journal.Pone.0185544 |
0.426 |
|
| 2017 |
Borchert AJ, Downs DM. The Response to 2-Aminoacrylate Differs in E. coli and S. enterica, Despite Shared Metabolic Components. Journal of Bacteriology. PMID 28461448 DOI: 10.1128/Jb.00140-17 |
0.448 |
|
| 2016 |
Bazurto JV, Downs DM. Metabolic network structure and function in bacteria goes beyond conserved enzyme components. Microbial Cell (Graz, Austria). 3: 260-262. PMID 28357363 DOI: 10.15698/Mic2016.06.509 |
0.8 |
|
| 2016 |
Ernst DC, Anderson ME, Downs DM. L-2,3-diaminopropionate generates diverse metabolic stresses in Salmonella enterica. Molecular Microbiology. PMID 27010356 DOI: 10.1111/Mmi.13384 |
0.439 |
|
| 2016 |
Bazurto JV, Farley KR, Downs DM. An Unexpected Route to an Essential Cofactor: Escherichia coli Relies on Threonine for Thiamine Biosynthesis. Mbio. 7. PMID 26733068 DOI: 10.1128/Mbio.01840-15 |
0.816 |
|
| 2015 |
Ernst DC, Downs DM. 2-Aminoacrylate Stress Induces a Context-Dependent Glycine Requirement in ridA Strains of Salmonella enterica. Journal of Bacteriology. 198: 536-43. PMID 26574511 DOI: 10.1128/Jb.00804-15 |
0.463 |
|
| 2015 |
Palmer LD, Paxhia MD, Downs DM. Induction of the Sugar-Phosphate Stress Response Allows Saccharomyces cerevisiae 2-Methyl-4-Amino-5-Hydroxymethylpyrimidine Phosphate Synthase To Function in Salmonella enterica. Journal of Bacteriology. 197: 3554-62. PMID 26324451 DOI: 10.1128/Jb.00576-15 |
0.417 |
|
| 2015 |
Bazurto JV, Heitman NJ, Downs DM. Aminoimidazole Carboxamide Ribotide Exerts Opposing Effects on Thiamine Synthesis in Salmonella enterica. Journal of Bacteriology. 197: 2821-30. PMID 26100042 DOI: 10.1128/Jb.00282-15 |
0.807 |
|
| 2015 |
Niehaus TD, Gerdes S, Hodge-Hanson K, Zhukov A, Cooper AJ, ElBadawi-Sidhu M, Fiehn O, Downs DM, Hanson AD. Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family. Bmc Genomics. 16: 382. PMID 25975565 DOI: 10.1186/S12864-015-1584-3 |
0.4 |
|
| 2015 |
Ernst DC, Downs DM. The STM4195 gene product (PanS) transports coenzyme A precursors in Salmonella enterica. Journal of Bacteriology. 197: 1368-77. PMID 25645561 DOI: 10.1128/Jb.02506-14 |
0.407 |
|
| 2015 |
Downs DM, Ernst DC. From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species. Molecular Microbiology. 96: 211-9. PMID 25620221 DOI: 10.1111/Mmi.12945 |
0.476 |
|
| 2014 |
Palmer LD, Leung MH, Downs DM. The cysteine desulfhydrase CdsH is conditionally required for sulfur mobilization to the thiamine thiazole in Salmonella enterica. Journal of Bacteriology. 196: 3964-70. PMID 25182497 DOI: 10.1128/Jb.02159-14 |
0.411 |
|
| 2014 |
Niehaus TD, Nguyen TN, Gidda SK, ElBadawi-Sidhu M, Lambrecht JA, McCarty DR, Downs DM, Cooper AJ, Fiehn O, Mullen RT, Hanson AD. Arabidopsis and maize RidA proteins preempt reactive enamine/imine damage to branched-chain amino acid biosynthesis in plastids. The Plant Cell. 26: 3010-22. PMID 25070638 DOI: 10.1105/Tpc.114.126854 |
0.398 |
|
| 2014 |
Ernst DC, Lambrecht JA, Schomer RA, Downs DM. Endogenous synthesis of 2-aminoacrylate contributes to cysteine sensitivity in Salmonella enterica. Journal of Bacteriology. 196: 3335-42. PMID 25002544 DOI: 10.1128/Jb.01960-14 |
0.513 |
|
| 2014 |
Bazurto JV, Downs DM. Amino-4-imidazolecarboxamide ribotide directly inhibits coenzyme A biosynthesis in Salmonella enterica. Journal of Bacteriology. 196: 772-9. PMID 24296672 DOI: 10.1128/Jb.01087-13 |
0.836 |
|
| 2013 |
Palmer LD, Downs DM. The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites. The Journal of Biological Chemistry. 288: 30693-9. PMID 24014032 DOI: 10.1074/Jbc.M113.500280 |
0.413 |
|
| 2013 |
Flynn JM, Christopherson MR, Downs DM. Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase. Molecular Microbiology. 89: 751-9. PMID 23815688 DOI: 10.1111/Mmi.12313 |
0.827 |
|
| 2013 |
Flynn JM, Downs DM. In the absence of RidA, endogenous 2-aminoacrylate inactivates alanine racemases by modifying the pyridoxal 5'-phosphate cofactor. Journal of Bacteriology. 195: 3603-9. PMID 23749972 DOI: 10.1128/Jb.00463-13 |
0.698 |
|
| 2013 |
Lambrecht JA, Schmitz GE, Downs DM. RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life. Mbio. 4: e00033-13. PMID 23386433 DOI: 10.1128/Mbio.00033-13 |
0.824 |
|
| 2013 |
Lambrecht JA, Downs DM. Anthranilate phosphoribosyl transferase (TrpD) generates phosphoribosylamine for thiamine synthesis from enamines and phosphoribosyl pyrophosphate. Acs Chemical Biology. 8: 242-8. PMID 23101964 DOI: 10.1021/Cb300364K |
0.415 |
|
| 2012 |
Koenigsknecht MJ, Lambrecht JA, Fenlon LA, Downs DM. Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica. Plos One. 7: e48207. PMID 23133571 DOI: 10.1371/Journal.Pone.0048207 |
0.795 |
|
| 2012 |
Palmer LD, Dougherty MJ, Downs DM. Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica. Journal of Bacteriology. 194: 6088-95. PMID 22961850 DOI: 10.1128/Jb.01361-12 |
0.424 |
|
| 2012 |
Christopherson MR, Lambrecht JA, Downs D, Downs DM. Suppressor analyses identify threonine as a modulator of ridA mutant phenotypes in Salmonella enterica. Plos One. 7: e43082. PMID 22900093 DOI: 10.1371/Journal.Pone.0043082 |
0.832 |
|
| 2012 |
Boyd JM, Teoh WP, Downs DM. Decreased transport restores growth of a Salmonella enterica apbC mutant on tricarballylate. Journal of Bacteriology. 194: 576-83. PMID 22101844 DOI: 10.1128/Jb.05988-11 |
0.482 |
|
| 2012 |
Lambrecht JA, Flynn JM, Downs DM. Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions. The Journal of Biological Chemistry. 287: 3454-61. PMID 22094463 DOI: 10.1074/Jbc.M111.304477 |
0.643 |
|
| 2011 |
Martinez-Gomez NC, Palmer LD, Vivas E, Roach PL, Downs DM. The rhodanese domain of ThiI is both necessary and sufficient for synthesis of the thiazole moiety of thiamine in Salmonella enterica. Journal of Bacteriology. 193: 4582-7. PMID 21724998 DOI: 10.1128/Jb.05325-11 |
0.425 |
|
| 2011 |
Boyd JM, Endrizzi JA, Hamilton TL, Christopherson MR, Mulder DW, Downs DM, Peters JW. FAD binding by ApbE protein from Salmonella enterica: a new class of FAD-binding proteins. Journal of Bacteriology. 193: 887-95. PMID 21148731 DOI: 10.1128/Jb.00730-10 |
0.799 |
|
| 2011 |
Bazurto JV, Downs DM. Plasticity in the purine-thiamine metabolic network of Salmonella. Genetics. 187: 623-31. PMID 21135073 DOI: 10.1534/Genetics.110.124362 |
0.801 |
|
| 2010 |
Lambrecht JA, Browne BA, Downs DM. Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro. The Journal of Biological Chemistry. 285: 34401-7. PMID 20817725 DOI: 10.1074/Jbc.M110.160515 |
0.744 |
|
| 2010 |
Koenigsknecht MJ, Downs DM. Thiamine biosynthesis can be used to dissect metabolic integration. Trends in Microbiology. 18: 240-7. PMID 20382023 DOI: 10.1016/J.Tim.2010.03.003 |
0.748 |
|
| 2010 |
Koenigsknecht MJ, Fenlon LA, Downs DM. Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica. Microbiology (Reading, England). 156: 950-9. PMID 19959576 DOI: 10.1099/Mic.0.033050-0 |
0.784 |
|
| 2009 |
Lewis JA, Boyd JM, Downs DM, Escalante-Semerena JC. Involvement of the Cra global regulatory protein in the expression of the iscRSUA operon, revealed during studies of tricarballylate catabolism in Salmonella enterica. Journal of Bacteriology. 191: 2069-76. PMID 19136587 DOI: 10.1128/Jb.01577-08 |
0.639 |
|
| 2009 |
Thorgersen MP, Downs DM. Oxidative stress and disruption of labile iron generate specific auxotrophic requirements in Salmonella enterica. Microbiology (Reading, England). 155: 295-304. PMID 19118370 DOI: 10.1099/Mic.0.020727-0 |
0.734 |
|
| 2009 |
Boyd JM, Drevland RM, Downs DM, Graham DE. Archaeal ApbC/Nbp35 homologs function as iron-sulfur cluster carrier proteins. Journal of Bacteriology. 191: 1490-7. PMID 19114487 DOI: 10.1128/Jb.01469-08 |
0.39 |
|
| 2009 |
Martinez-Gomez NC, Poyner RR, Mansoorabadi SO, Reed GH, Downs DM. Reaction of AdoMet with ThiC generates a backbone free radical. Biochemistry. 48: 217-9. PMID 19113839 DOI: 10.1021/Bi802154J |
0.329 |
|
| 2009 |
Boyd JM, Sondelski JL, Downs DM. Bacterial ApbC protein has two biochemical activities that are required for in vivo function. The Journal of Biological Chemistry. 284: 110-8. PMID 19001370 DOI: 10.1074/Jbc.M807003200 |
0.386 |
|
| 2008 |
Thorgersen MP, Downs DM. Analysis of yggX and gshA mutants provides insights into the labile iron pool in Salmonella enterica. Journal of Bacteriology. 190: 7608-13. PMID 18835989 DOI: 10.1128/Jb.00639-08 |
0.743 |
|
| 2008 |
Martinez-Gomez NC, Downs DM. ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis. Biochemistry. 47: 9054-6. PMID 18686975 DOI: 10.1021/Bi8010253 |
0.423 |
|
| 2008 |
Boyd JM, Pierik AJ, Netz DJ, Lill R, Downs DM. Bacterial ApbC can bind and effectively transfer iron-sulfur clusters. Biochemistry. 47: 8195-202. PMID 18616280 DOI: 10.1021/Bi800551Y |
0.374 |
|
| 2008 |
Boyd JM, Lewis JA, Escalante-Semerena JC, Downs DM. Salmonella enterica requires ApbC function for growth on tricarballylate: evidence of functional redundancy between ApbC and IscU. Journal of Bacteriology. 190: 4596-602. PMID 18441067 DOI: 10.1128/Jb.00262-08 |
0.673 |
|
| 2008 |
Christopherson MR, Schmitz GE, Downs DM. YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium. Journal of Bacteriology. 190: 3057-62. PMID 18296521 DOI: 10.1128/Jb.01700-07 |
0.791 |
|
| 2008 |
Ramos I, Vivas EI, Downs DM. Mutations in the tryptophan operon allow purF-independent thiamine synthesis by altering flux in vivo Journal of Bacteriology. 190: 815-822. PMID 17557816 DOI: 10.1128/Jb.00582-07 |
0.478 |
|
| 2007 |
Thorgersen MP, Downs DM. Cobalt targets multiple metabolic processes in Salmonella enterica. Journal of Bacteriology. 189: 7774-81. PMID 17720790 DOI: 10.1128/Jb.00962-07 |
0.769 |
|
| 2007 |
Koenigsknecht MJ, Ramos I, Downs DM. Glutamine phosphoribosylpyrophosphate amidotransferase-independent phosphoribosyl amine synthesis from ribose 5-phosphate and glutamine or asparagine. The Journal of Biological Chemistry. 282: 28379-84. PMID 17686772 DOI: 10.1074/Jbc.M704024200 |
0.763 |
|
| 2006 |
Dougherty MJ, Boyd JM, Downs DM. Inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of Salmonella enterica purH mutants on glycerol. The Journal of Biological Chemistry. 281: 33892-9. PMID 16987812 DOI: 10.1074/Jbc.M604429200 |
0.454 |
|
| 2006 |
Browne BA, Ramos AI, Downs DM. PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase. Journal of Bacteriology. 188: 6786-92. PMID 16980480 DOI: 10.1128/Jb.00745-06 |
0.762 |
|
| 2006 |
Dougherty MJ, Downs DM. A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica. Microbiology (Reading, England). 152: 2345-53. PMID 16849799 DOI: 10.1099/Mic.0.28926-0 |
0.458 |
|
| 2006 |
Downs DM. Understanding microbial metabolism. Annual Review of Microbiology. 60: 533-59. PMID 16771650 DOI: 10.1146/Annurev.Micro.60.080805.142308 |
0.406 |
|
| 2006 |
Schmitz GE, Downs DM. An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source. Journal of Bacteriology. 188: 3126-9. PMID 16585773 DOI: 10.1128/Jb.188.8.3126-3129.2006 |
0.801 |
|
| 2006 |
Vivas E, Skovran E, Downs DM. Salmonella enterica strains lacking the frataxin homolog cyaY show defects in Fe-S cluster metabolism in vivo Journal of Bacteriology. 188: 1175-1179. PMID 16428423 DOI: 10.1128/Jb.188.3.1175-1179.2006 |
0.783 |
|
| 2006 |
Cui Q, Thorgersen MP, Westler WM, Markley JL, Downs DM. Solution structure of YggX: a prokaryotic protein involved in Fe(II) trafficking. Proteins. 62: 578-86. PMID 16329120 DOI: 10.1002/Prot.20781 |
0.711 |
|
| 2005 |
Downs DM, Schmitz GE, Skovran E. Probing the complex system of metabolic integration. Progress in Nucleic Acid Research and Molecular Biology. 80: 43-94. PMID 16164972 DOI: 10.1016/S0079-6603(05)80002-9 |
0.774 |
|
| 2004 |
Skovran E, Lauhon CT, Downs DM. Lack of YggX results in chronic oxidative stress and uncovers subtle defects in Fe-S cluster metabolism in Salmonella enterica Journal of Bacteriology. 186: 7626-7634. PMID 15516576 DOI: 10.1128/Jb.186.22.7626-7634.2004 |
0.796 |
|
| 2004 |
Martinez-Gomez NC, Robers M, Downs DM. Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily. The Journal of Biological Chemistry. 279: 40505-10. PMID 15271986 DOI: 10.1074/Jbc.M403985200 |
0.492 |
|
| 2004 |
Dougherty MJ, Downs DM. A mutant allele of rpoD results in increased conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine in Salmonella enterica. Journal of Bacteriology. 186: 4034-7. PMID 15175319 DOI: 10.1128/Jb.186.12.4034-4037.2004 |
0.497 |
|
| 2004 |
Lauhon CT, Skovran E, Urbina HD, Downs DM, Vickery LE. Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. The Journal of Biological Chemistry. 279: 19551-8. PMID 14978044 DOI: 10.1074/Jbc.M401261200 |
0.786 |
|
| 2004 |
Schmitz G, Downs DM. Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium. Journal of Bacteriology. 186: 803-10. PMID 14729707 DOI: 10.1128/Jb.186.3.803-810.2004 |
0.814 |
|
| 2003 |
Beck BJ, Huelsmeyer M, Paul S, Downs DM. A Mutation in the Essential Gene gmk (Encoding Guanlyate Kinase) Generates a Requirement for Adenine at Low Temperature in Salmonella enterica Journal of Bacteriology. 185: 6732-6735. PMID 14594851 DOI: 10.1128/Jb.185.22.6732-6735.2003 |
0.435 |
|
| 2003 |
Ramos I, Downs DM. Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica. Journal of Bacteriology. 185: 5125-32. PMID 12923085 DOI: 10.1128/Jb.185.17.5125-5132.2003 |
0.541 |
|
| 2003 |
Gralnick JA, Downs DM. The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. The Journal of Biological Chemistry. 278: 20708-15. PMID 12670952 DOI: 10.1074/Jbc.M301577200 |
0.673 |
|
| 2003 |
Dougherty M, Downs DM. The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains. Journal of Bacteriology. 185: 332-9. PMID 12486071 DOI: 10.1128/Jb.185.1.332-339.2003 |
0.464 |
|
| 2003 |
Skovran E, Downs DM. Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium. Journal of Bacteriology. 185: 98-106. PMID 12486045 DOI: 10.1128/Jb.185.1.98-106.2003 |
0.786 |
|
| 2002 |
Allen S, Zilles JL, Downs DM. Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella enterica. Journal of Bacteriology. 184: 6130-7. PMID 12399482 DOI: 10.1128/Jb.184.22.6130-6137.2002 |
0.758 |
|
| 2002 |
Rubio A, Downs DM. Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme a elevation in Salmonella enterica serovar typhimurium Journal of Bacteriology. 184: 2827-2832. PMID 11976313 DOI: 10.1128/Jb.184.10.2827-2832.2002 |
0.752 |
|
| 2001 |
Gralnick J, Downs D. Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica. Proceedings of the National Academy of Sciences of the United States of America. 98: 8030-5. PMID 11416172 DOI: 10.1073/Pnas.151243198 |
0.647 |
|
| 2001 |
Zilles JL, Kappock TJ, Stubbe J, Downs DM. Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase. Journal of Bacteriology. 183: 2234-40. PMID 11244062 DOI: 10.1128/Jb.183.7.2234-2240.2001 |
0.755 |
|
| 2000 |
Zilles JL, Croal LR, Downs DM. Action of the thiamine protagonist bacimethrin on thiamine biosynthesis Journal of Bacteriology. 182: 5606-5610. PMID 10986269 DOI: 10.1128/Jb.182.19.5606-5610.2000 |
0.716 |
|
| 2000 |
Gralnick J, Webb E, Beck B, Downs D. Lesions in gshA (Encoding gamma-L-glutamyl-L-cysteine synthetase) prevent aerobic synthesis of thiamine in Salmonella enterica serovar typhimurium LT2. Journal of Bacteriology. 182: 5180-7. PMID 10960103 DOI: 10.1128/Jb.182.18.5180-5187.2000 |
0.729 |
|
| 2000 |
Skovran E, Downs DM. Metabolic defects caused by mutations in the isc gene cluster in Salmonella enterica serovar typhimurium: Implications for thiamine synthesis Journal of Bacteriology. 182: 3896-3903. PMID 10869064 DOI: 10.1128/Jb.182.14.3896-3903.2000 |
0.812 |
|
| 2000 |
Frodyma M, Rubio A, Downs DM. Reduced flux through the purine biosynthetic pathway results in an increased requirement for coenzyme A in thiamine synthesis in Salmonella enterica serovar Typhimurium Journal of Bacteriology. 182: 236-240. PMID 10613889 DOI: 10.1128/Jb.182.1.236-240.2000 |
0.775 |
|
| 2000 |
Claas K, Weber S, Downs DM. Lesions in the nuo operon, encoding NADH dehydrogenase complex I, prevent PurF-independent thiamine synthesis and reduce flux through the oxidative pentose phosphate pathway in Salmonella enterica serovar typhimurium Journal of Bacteriology. 182: 228-232. PMID 10613887 DOI: 10.1128/Jb.182.1.228-232.2000 |
0.48 |
|
| 2000 |
Downs DM, Escalante-Semerena JC. Impact of genomics and genetics on the elucidation of bacterial metabolism Methods. 20: 47-54. PMID 10610803 DOI: 10.1006/Meth.1999.0904 |
0.602 |
|
| 1999 |
Beck BJ, Downs DM. A periplasmic location is essential for the role of the ApbE lipoprotein in thiamine synthesis in Salmonella typhimurium Journal of Bacteriology. 181: 7285-7290. PMID 10572132 DOI: 10.1128/Jb.181.23.7285-7290.1999 |
0.392 |
|
| 1999 |
Christian T, Downs DM. Defects in pyruvate kinase cause a conditional increase of thiamine synthesis in Salmonella typhimurium. Canadian Journal of Microbiology. 45: 565-72. PMID 10497788 DOI: 10.1139/W99-042 |
0.501 |
|
| 1999 |
Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J. Thiamin biosynthesis in prokaryotes. Archives of Microbiology. 171: 293-300. PMID 10382260 DOI: 10.1007/S002030050713 |
0.341 |
|
| 1999 |
Enos-Berlage JL, Downs DM. Biosynthesis of the pyrimidine moiety of thiamine independent of the PurF enzyme (phosphoribosylpyrophosphate amidotransferase) in Salmonella typhimurium: Incorporation of stable isotope-labeled glycine and formate Journal of Bacteriology. 181: 841-848. PMID 9922247 DOI: 10.1128/Jb.181.3.841-848.1999 |
0.437 |
|
| 1998 |
Enos-Berlage JL, Langendorf MJ, Downs DM. Complex metabolic phenotypes caused by a mutation in yjgF, encoding a member of the highly conserved YER057c/YjgF family of proteins Journal of Bacteriology. 180: 6519-6528. PMID 9851994 DOI: 10.1128/Jb.180.24.6519-6528.1998 |
0.523 |
|
| 1998 |
Frodyma ME, Downs D. The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium Journal of Bacteriology. 180: 4757-4759. PMID 9721324 DOI: 10.1128/Jb.180.17.4757-4759.1998 |
0.4 |
|
| 1998 |
Kim YS, Nosaka K, Downs DM, Kwak JM, Park D, Chung IK, Nam HG. A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase involved in thiamin biosynthesis. Plant Molecular Biology. 37: 955-66. PMID 9700068 DOI: 10.1023/A:1006030617502 |
0.385 |
|
| 1998 |
Webb E, Claas K, Downs D. thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium. The Journal of Biological Chemistry. 273: 8946-50. PMID 9535878 DOI: 10.1074/Jbc.273.15.8946 |
0.367 |
|
| 1998 |
Frodyma ME, Downs D. ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway Journal of Biological Chemistry. 273: 5572-5576. PMID 9488683 DOI: 10.1074/Jbc.273.10.5572 |
0.353 |
|
| 1998 |
Beck BJ, Downs DM. The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium Journal of Bacteriology. 180: 885-891. PMID 9473043 DOI: 10.1128/Jb.180.4.885-891.1998 |
0.452 |
|
| 1997 |
Beck BJ, Connolly LE, De las Penas A, Downs DM. Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium Journal of Bacteriology. 179: 6504-6508. PMID 9335303 DOI: 10.1128/Jb.179.20.6504-6508.1997 |
0.409 |
|
| 1997 |
Petersen LA, Downs DM. Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis Journal of Bacteriology. 179: 4894-4900. PMID 9244280 DOI: 10.1128/Jb.179.15.4894-4900.1997 |
0.389 |
|
| 1997 |
Webb E, Claas K, Downs DM. Characterization of thiI, a new gene involved in thiazole biosynthesis in Salmonella typhimurium Journal of Bacteriology. 179: 4399-4402. PMID 9209060 DOI: 10.1128/Jb.179.13.4399-4402.1997 |
0.396 |
|
| 1997 |
Enos-Berlage JL, Downs DM. Mutations in sdh (succinate dehydrogenase genes) alter the thiamine requirement of Salmonella typhimurium Journal of Bacteriology. 179: 3989-3996. PMID 9190816 DOI: 10.1128/Jb.179.12.3989-3996.1997 |
0.509 |
|
| 1997 |
Webb E, Downs D. Characterization of thiL, encoding thiamin-monophosphate kinase, in Salmonella typhimurium. The Journal of Biological Chemistry. 272: 15702-7. PMID 9188462 DOI: 10.1074/Jbc.272.25.15702 |
0.365 |
|
| 1996 |
Zilles JL, Downs DM. A novel involvement of the PurG and PurI proteins in thiamine synthesis via the alternative pyrimidine biosynthetic (APB) pathway in Salmonella typhimurium Genetics. 144: 883-892. PMID 8913735 |
0.366 |
|
| 1996 |
Petersen L, Downs DM. Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium Journal of Bacteriology. 178: 5676-5682. PMID 8824612 DOI: 10.1128/Jb.178.19.5676-5682.1996 |
0.483 |
|
| 1996 |
Petersen L, Enos-Berlage J, Downs DM. Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium Genetics. 143: 37-44. PMID 8722760 |
0.384 |
|
| 1996 |
Enos-Berlage JL, Downs DM. Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium Journal of Bacteriology. 178: 1476-1479. PMID 8631729 DOI: 10.1128/Jb.178.5.1476-1479.1996 |
0.387 |
|
| 1996 |
Webb E, Febres F, Downs DM. Thiamine pyrophosphate (TPP) negatively regulates transcription of some thi genes of Salmonella typhimurium Journal of Bacteriology. 178: 2533-2538. PMID 8626319 DOI: 10.1128/Jb.178.9.2533-2538.1996 |
0.435 |
|
| 1994 |
Downs DM, Petersen L. apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium Journal of Bacteriology. 176: 4858-4864. PMID 7519593 DOI: 10.1128/Jb.176.16.4858-4864.1994 |
0.464 |
|
| 1993 |
Downs DM, Ludden PW, Shah VK. Accumulation of factor F395 in nifNE mutants of Klebsiella pneumoniae Canadian Journal of Microbiology. 39: 351-354. PMID 8477353 DOI: 10.1139/M93-050 |
0.315 |
|
| 1992 |
Downs DM. Evidence for a new, oxygen-regulated biosynthetic pathway for the pyrimidine moiety of thiamine in Salmonella typhimurium Journal of Bacteriology. 174: 1515-1521. PMID 1537796 DOI: 10.1128/Jb.174.5.1515-1521.1992 |
0.386 |
|
| 1991 |
Downs DM, Roth JR. Synthesis of thiamine in Salmonella typhimurium independent of the purF function Journal of Bacteriology. 173: 6597-6604. PMID 1917881 DOI: 10.1128/Jb.173.20.6597-6604.1991 |
0.593 |
|
| 1990 |
Downs DM, Ludden PW, Shah VK. Synthesis of the iron-molybdenum cofactor of nitrogenase is inhibited by a low-molecular-weight metabolite of Klebsiella pneumoniae Journal of Bacteriology. 172: 6084-6089. PMID 2211526 DOI: 10.1128/Jb.172.10.6084-6089.1990 |
0.357 |
|
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