Donald D. Muccio - Publications

Affiliations: 
University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Biochemistry, Microbiology Biology

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ren G, Kim T, Kim HS, Young ME, Muccio DD, Atigadda VR, Blum SI, Tse HM, Habegger KM, Bhatnagar S, Coric T, Bjornsti MA, Shalev A, Frank SJ, Kim JA. A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders. Diabetes. PMID 32611548 DOI: 10.2337/db19-1001  0.32
2019 Kolesar JM, Andrews S, Green H, Havighurst TC, Wollmer BW, DeShong K, Laux DE, Krontiras H, Muccio DD, Kim K, Grubbs CJ, House MG, Parnes HL, Heckman-Stoddard BM, Bailey HH. A Randomized, Placebo-Controlled, Double-Blind, Dose Escalation, Single Dose and Steady State Pharmacokinetics Study of 9cUAB30 in Healthy Volunteers. Cancer Prevention Research (Philadelphia, Pa.). PMID 31484659 DOI: 10.1158/1940-6207.CAPR-19-0310  0.32
2018 Williams AP, Waters AM, Stewart JE, Atigadda VR, Mroczek-Musulman E, Muccio DD, Grubbs CJ, Beierle EA. A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro. The Journal of Surgical Research. 228: 54-62. PMID 29907230 DOI: 10.1016/j.jss.2018.02.057  0.44
2018 Chou CF, Hsieh YH, Grubbs CJ, Atigadda VR, Mobley JA, Dummer R, Muccio DD, Eto I, Elmets CA, Garvey WT, Chang PL. The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. Journal of Dermatological Science. PMID 29599065 DOI: 10.1016/j.jdermsci.2018.03.006  0.44
2016 Muccio DD, Atigadda VR, Brouillette WJ, Bland KI, Krontiras H, Grubbs CJ. Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention. Current Topics in Medicinal Chemistry. PMID 27320329  0.44
2016 Wu L, Chaudhary SC, Atigadda VR, Belyaeva OV, Harville SR, Elmets CA, Muccio DD, Athar M, Kedishvili NY. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. Plos One. 11: e0153556. PMID 27078158 DOI: 10.1371/journal.pone.0153556  0.32
2016 Waters AM, Stewart JE, Atigadda VR, Mroczek-Musulman E, Muccio DD, Grubbs CJ, Beierle EA. Pre-Clinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies. Molecular Cancer Therapeutics. PMID 26873726 DOI: 10.1158/1535-7163.MCT-15-0521  0.44
2015 Atigadda VR, Xia G, Deshpande A, Wu L, Kedishvili N, Smith CD, Krontiras H, Bland KI, Grubbs CJ, Brouillette WJ, Muccio DD. Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. Journal of Medicinal Chemistry. 58: 7763-74. PMID 26331194 DOI: 10.1021/acs.jmedchem.5b00829  0.52
2015 Waters AM, Stewart JE, Atigadda VR, Mroczek-Musulman E, Muccio DD, Grubbs CJ, Beierle EA. Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma. Molecular Cancer Therapeutics. PMID 25944918 DOI: 10.1158/1535-7163.MCT-14-1103  0.52
2014 Atigadda VR, Xia G, Desphande A, Boerma LJ, Lobo-Ruppert S, Grubbs CJ, Smith CD, Brouillette WJ, Muccio DD. Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. Journal of Medicinal Chemistry. 57: 5370-80. PMID 24801499 DOI: 10.1021/jm5004792  0.52
2014 Desphande A, Xia G, Boerma LJ, Vines KK, Atigadda VR, Lobo-Ruppert S, Grubbs CJ, Moeinpour FL, Smith CD, Christov K, Brouillette WJ, Muccio DD. Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorganic & Medicinal Chemistry. 22: 178-85. PMID 24359708 DOI: 10.1016/j.bmc.2013.11.039  0.52
2014 Boerma LJ, Xia G, Qui C, Cox BD, Chalmers MJ, Smith CD, Lobo-Ruppert S, Griffin PR, Muccio DD, Renfrow MB. Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain. The Journal of Biological Chemistry. 289: 814-26. PMID 24187139 DOI: 10.1074/jbc.M113.476861  0.52
2013 Cox BD, Muccio DD, Hamilton TP. Conformational Analysis of Retinoic Acids: Effects of Steric Interactions on Nonplanar Conjugated Polyenes. Computational & Theoretical Chemistry. 1011: 11-20. PMID 25798372 DOI: 10.1016/j.comptc.2013.01.013  0.52
2013 Vedell PT, Lu Y, Grubbs CJ, Yin Y, Jiang H, Bland KI, Muccio DD, Cvetkovic D, You M, Lubet R. Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene). Molecular Pharmacology. 83: 698-708. PMID 23292798 DOI: 10.1124/mol.112.082404  0.52
2012 Cabrera MC, Díaz-Cruz ES, Kallakury BV, Pishvaian MJ, Grubbs CJ, Muccio DD, Furth PA. The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway. Cancer Prevention Research (Philadelphia, Pa.). 5: 810-21. PMID 22508966 DOI: 10.1158/1940-6207.CAPR-11-0532-T  0.52
2012 Whitworth JM, Londoño-Joshi AI, Sellers JC, Oliver PJ, Muccio DD, Atigadda VR, Straughn JM, Buchsbaum DJ. The impact of novel retinoids in combination with platinum chemotherapy on ovarian cancer stem cells. Gynecologic Oncology. 125: 226-30. PMID 22155260 DOI: 10.1016/j.ygyno.2011.12.425  0.52
2012 Whitworth JM, Straughn JM, Atigadda VR, Muccio DD, Buchsbaum DJ. The use of retinoids in ovarian cancer: a review of the literature. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 22: 191-8. PMID 22146768 DOI: 10.1097/IGC.0b013e318236a2ec  0.52
2011 Jackson PL, Noerager BD, Jablonsky MJ, Hardison MT, Cox BD, Patterson JC, Dhanapal B, Blalock JE, Muccio DD. A CXCL8 receptor antagonist based on the structure of N-acetyl-proline-glycine-proline. European Journal of Pharmacology. 668: 435-42. PMID 21458447 DOI: 10.1016/j.ejphar.2011.02.045  0.52
2011 Xia G, Boerma LJ, Cox BD, Qiu C, Kang S, Smith CD, Renfrow MB, Muccio DD. Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9-cis-retinoic acid. Biochemistry. 50: 93-105. PMID 21049972 DOI: 10.1021/bi101288y  0.52
2010 Kolesar JM, Hoel R, Pomplun M, Havighurst T, Stublaski J, Wollmer B, Krontiras H, Brouillette W, Muccio D, Kim K, Grubbs CJ, Bailey HE. A pilot, first-in-human, pharmacokinetic study of 9cUAB30 in healthy volunteers. Cancer Prevention Research (Philadelphia, Pa.). 3: 1565-70. PMID 21149332 DOI: 10.1158/1940-6207.CAPR-10-0149  0.52
2009 Jiang W, Deng W, Bailey SK, Nail CD, Frost AR, Brouillette WJ, Muccio DD, Grubbs CJ, Ruppert JM, Lobo-Ruppert SM. Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid. Cancer Biology & Therapy. 8: 289-98. PMID 19197145 DOI: 10.4161/cbt.8.3.7486  0.52
2008 Love WK, Deangelis JT, Berletch JB, Phipps SM, Andrews LG, Brouillette WJ, Muccio DD, Tollefsbol TO. The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells. Translational Oncology. 1: 148-52. PMID 18795149 DOI: 10.1593/tlo.08142  0.52
2007 Gorman GS, Coward L, Kerstner-Wood C, Cork L, Kapetanovic IM, Brouillette WJ, Muccio DD. In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1157-64. PMID 17446266 DOI: 10.1124/dmd.106.013938  0.52
2007 Lee YC, Jackson PL, Jablonsky MJ, Muccio DD. Conformation of 3'CMP bound to RNase A using TrNOESY. Archives of Biochemistry and Biophysics. 463: 37-46. PMID 17416340 DOI: 10.1016/j.abb.2007.02.034  0.52
2006 Nakatsuji T, Han DW, Jablonsky MJ, Harville SR, Muccio DD, Watson RD. Expression of crustacean (Callinectes sapidus) molt-inhibiting hormone in Escherichia coli: characterization of the recombinant peptide and assessment of its effects on cellular signaling pathways in Y-organs. Molecular and Cellular Endocrinology. 253: 96-104. PMID 16790313 DOI: 10.1016/j.mce.2006.05.004  0.4
2006 Grubbs CJ, Lubet RA, Atigadda VR, Christov K, Deshpande AM, Tirmal V, Xia G, Bland KI, Eto I, Brouillette WJ, Muccio DD. Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers. Carcinogenesis. 27: 1232-9. PMID 16344269 DOI: 10.1093/carcin/bgi308  0.52
2004 Pal B, Pybus B, Muccio DD, Chattopadhyay D. Biochemical characterization and crystallization of recombinant 3-phosphoglycerate kinase of Plasmodium falciparum. Biochimica Et Biophysica Acta. 1699: 277-80. PMID 15158737 DOI: 10.1016/j.bbapap.2004.01.003  0.52
2004 Cormet-Boyaka E, Jablonsky M, Naren AP, Jackson PL, Muccio DD, Kirk KL. Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation. Proceedings of the National Academy of Sciences of the United States of America. 101: 8221-6. PMID 15141088 DOI: 10.1073/pnas.0400459101  0.52
2003 Grubbs CJ, Hill DL, Bland KI, Beenken SW, Lin TH, Eto I, Atigadda VR, Vines KK, Brouillette WJ, Muccio DD. 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers. Cancer Letters. 201: 17-24. PMID 14580682 DOI: 10.1016/S0304-3835(03)00461-0  0.52
2003 Atigadda VR, Vines KK, Grubbs CJ, Hill DL, Beenken SL, Bland KI, Brouillette WJ, Muccio DD. Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30). Journal of Medicinal Chemistry. 46: 3766-9. PMID 12904083 DOI: 10.1021/jm030095q  0.52
2002 Jones CL, Fish F, Muccio DD. Determination of RNase A/2'-cytidine monophosphate binding affinity and enthalpy by a global fit of thermal unfolding curves. Analytical Biochemistry. 302: 184-90. PMID 11878796 DOI: 10.1006/abio.2001.5529  0.52
2001 Lee YC, Jackson PL, Jablonsky MJ, Muccio DD, Pfister RR, Haddox JL, Sommers CI, Anantharamaiah GM, Chaddha M. NMR conformational analysis of cis and trans proline isomers in the neutrophil chemoattractant, N-acetyl-proline-glycine-proline. Biopolymers. 58: 548-61. PMID 11246204 DOI: 10.1002/1097-0282(200105)58:6<548::AID-BIP1030>3.0.CO;2-B  0.52
2001 Ponder MS, Alan Long J, Williams LM, Hamilton TP, Muccio DD. Structural studies on conformationally defined 6-s-trans UAB retinoids Journal of Molecular Structure: Theochem. 549: 39-45. DOI: 10.1016/S0166-1280(01)00490-0  0.52
1999 Haddox JL, Pfister RR, Muccio DD, Villain M, Sommers CI, Chaddha M, Anantharamaiah GM, Brouillette WJ, DeLucas LJ. Bioactivity of peptide analogs of the neutrophil chemoattractant, N- acetyl-proline-glycine-proline Investigative Ophthalmology and Visual Science. 40: 2427-2429. PMID 10476813  0.52
1999 Boersma BJ, Patel RP, Kirk M, Jackson PL, Muccio D, Darley-Usmar VM, Barnes S. Chlorination and nitration of soy isoflavones. Archives of Biochemistry and Biophysics. 368: 265-75. PMID 10441377 DOI: 10.1006/abbi.1999.1330  0.4
1999 Muccio DD, Lee YC, Alam M, Brouillette WJ. 1H and 13C NMR assignments of conformationally defined 6-s-cis-retinoids Magnetic Resonance in Chemistry. 37: 82-85.  0.52
1998 Muccio DD, Brouillette WJ, Breitman TR, Taimi M, Emanuel PD, Zhang X, Chen G, Sani BP, Venepally P, Reddy L, Alam M, Simpson-Herren L, Hill DL. Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias. Journal of Medicinal Chemistry. 41: 1679-87. PMID 9572893 DOI: 10.1021/jm970635h  0.52
1997 Shimada T, Ross AC, Muccio DD, Brouillette WJ, Shealy YF. Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoids Archives of Biochemistry and Biophysics. 344: 220-227. PMID 9244401 DOI: 10.1006/abbi.1997.0209  0.52
1997 Lake CH, Alam M, Muccio DD, Brouillette WJ. A structural model for a new class of conformationally constrained retinoid: (2Z,4E)-4-[3',4'-dihydro-1'(2'H)-naphthalene-1'-ylidene]-2-butenoic acid Journal of Chemical Crystallography. 27: 231-235.  0.52
1996 Muccio DD, Brouillette WJ, Alam M, Vaezi MF, Sani BP, Venepally P, Reddy L, Li E, Norris AW, Simpson-Herren L, Hill DL. Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity. Journal of Medicinal Chemistry. 39: 3625-35. PMID 8809153 DOI: 10.1021/jm9603126  0.52
1996 Lin TH, Rogers TS, Hill DL, Simpson-Herren L, Farnell DR, Kochhar DM, Alam M, Brouillette WJ, Muccio DD. Murine toxicology and pharmacology of UAB-8, a conformationally constrained analog of retinoic acid. Toxicology and Applied Pharmacology. 139: 310-6. PMID 8806847 DOI: 10.1006/taap.1996.0170  0.52
1996 Shimada T, Ross AC, Brouilelte W, Muccio DD, Malsuura T. Natural and synthetic retinoids induce hepatic lecithin: Retinol acyltransferase (LRAT) activity in vitamin A-deficient rats Faseb Journal. 10.  0.52
1995 Alam M, Zhestkov V, Sani BP, Venepally P, Levin AA, Kazmer S, Li E, Norris AW, Zhang XK, Lee MO, Hill DL, Lin TH, Brouillette WJ, Muccio DD. Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity Journal of Medicinal Chemistry. 38: 2302-2310. PMID 7608895  0.52
1995 Robinson CY, Waterhous DV, Muccio DD, Brouillette WJ. Conformationally constrained precursors to retinoic acid analogs which stabilize the 9Z-configuration Bioorganic and Medicinal Chemistry Letters. 5: 953-958. DOI: 10.1016/0960-894X(95)00151-I  0.52
1994 Vaezi MF, Alam M, Sani BP, Rogers TS, Simpson-Herren L, Wille JJ, Hill DL, Doran TI, Brouillette WJ, Muccio DD. A conformationally defined 6-s-trans-retinoic acid isomer: synthesis, chemopreventive activity, and toxicity. Journal of Medicinal Chemistry. 37: 4499-507. PMID 7799400  0.52
1994 Logan J, Hiestand D, Daram P, Huang Z, Muccio DD, Hartman J, Haley B, Cook WJ, Sorscher EJ. Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding Journal of Clinical Investigation. 94: 228-236. PMID 7518829  0.52
1992 Muccio DD, Waterhous DV, Fish F, Brouillette CG. Analysis of the two-state behavior of the thermal unfolding of serum retinol binding protein containing a single retinol ligand Biochemistry®. 31: 5560-5567. PMID 1610801  0.52
1992 Hartman J, Huang Z, Rado TA, Peng S, Jilling T, Muccio DD, Sorscher EJ. Recombinant synthesis, purification, and nucleotide binding characteristics of the first nucleotide binding domain of the cystic fibrosis gene product Journal of Biological Chemistry. 267: 6455-6458. PMID 1372605  0.52
1989 Robinson CY, Brouillette WJ, Muccio DD. Reactions of vinylogous phosphonate carbanions and Reformatsky reagents with a sterically hindered ketone and enone Journal of Organic Chemistry. 54: 1992-1997.  0.52
1987 Brouillette CG, Muccio DD, Finney TK. PH dependence of bacteriorhodopsin thermal unfolding Biochemistry. 26: 7431-7438. PMID 3427085  0.52
1987 Vaezi MF, Robinson CY, Hope KD, Brouillette WJ, Muccio DD. Preparation of the 9-cis, 13-cis-, and all trans-isomers of α- and β2-retinal Organic Preparations and Procedures International. 19: 187-195. DOI: 10.1080/00304948709356186  0.52
1987 Chang C, Fish F, Muccio DD, St. Pierre T. 13C and 15N NMR pH titration of poly(vinylamine): A two-stage process sensitive to polymer tacticity Macromolecules. 20: 621-625.  0.52
1986 Chang C, Muccio DD, St. Pierre T. DETERMINATION OF THE SEQUENCE DISTRIBUTION AND IONIZATION CONSTANT OF POLY(ACRYLIC ACID-CO-VINYLAMINE) BY C-13 NMR Journal of Polymer Science. Part C, Polymer Symposia. 17-30.  0.52
1986 Chang C, Muccio DD, Pierre TS, Chen CC, Overberger CG. A configurational study of poly(vinylamine) by multinuclear nuclear magnetic resonance Macromolecules. 19: 913-916.  0.52
1985 Waterhous DV, Barnes S, Muccio DD. Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5β-cholanoic acid Journal of Lipid Research. 26: 1068-1078. PMID 4067429  0.52
1985 Muccio DD, DeLucas LJ. Isolation of detergent-solubilized monomers of bacteriorhodopsin by size-exclusion high-performance liquid chromatography Journal of Chromatography A. 326: 243-250. PMID 4030944 DOI: 10.1016/S0021-9673(01)87450-1  0.52
1985 Chang C, Muccio DD, St. Pierre T. Determination of the tacticity and analysis of the pH titration of poly(acrylic acid) by 1H and 13C NMR Macromolecules. 18: 2154-2157.  0.52
1985 Chang C, Muccio DD, Pierre TS. Heteronuclear correlated two-dimensional NMR spectroscopy applied to the diad assignment of vinyl polymers Macromolecules. 18: 2334-2337.  0.52
1985 Iqbal M, Copan WG, Muccio DD, Mateescu GD. Synthesis of 13C single and double labelled retinals, precursors for NMR studies of visual pigments and related systems Journal of Labelled Compounds and Radiopharmaceuticals. 22: 807-817.  0.52
1985 Chang C, Muccio DD, St. Pierre T, Chen CC, Overberger CG. CONFIGURATIONAL STUDY OF POLY(VINYLAMINE) American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 26: 263-264.  0.52
1984 Delucas LJ, Muccio DD. Purification of bovine rhodopsin by high-performance size-exclusion chromatography Journal of Chromatography A. 296: 121-128. PMID 6480737 DOI: 10.1016/S0021-9673(01)96406-4  0.52
1984 Brouillette WJ, Friedrich JD, Muccio DD. Synthesis and carbon-13 NMR of an unusual tricyclic barbituric acid derivative Journal of Organic Chemistry. 49: 3227-3230.  0.52
1981 Mateescu GD, Muccio DD, Copan WG, Abrahamson EW. Nuclear magnetic resonance studies of rhodopsin and bacteriorhodopsin Journal of Photochemistry. 17: 63.  0.52
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