Clay F. Semenkovich - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
General Biology, Medicine and Surgery, Molecular Biology

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lu D, He A, Tan M, Mrad M, El Daibani A, Hu D, Liu X, Kleiboeker B, Che T, Hsu FF, Bambouskova M, Semenkovich CF, Lodhi IJ. Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Nature Communications. 15: 4214. PMID 38760332 DOI: 10.1038/s41467-024-48471-2  0.362
2024 Kleiboeker B, He A, Tan M, Lu D, Hu D, Liu X, Goodarzi P, Hsu FF, Razani B, Semenkovich CF, Lodhi IJ. Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis. Molecular Metabolism. 101913. PMID 38458567 DOI: 10.1016/j.molmet.2024.101913  0.403
2024 Worthmann A, Ridder J, Piel SYL, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer AW, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, ... ... Semenkovich CF, et al. Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use. Nature Communications. 15: 45. PMID 38167725 DOI: 10.1038/s41467-023-44364-y  0.337
2020 Li Y, Su X, Rohatgi N, Zhang Y, Brestoff JR, Shoghi KI, Xu Y, Semenkovich CF, Harris CA, Peterson LL, Weibaecher KN, Teitelbaum SL, Zou W. Hepatic lipids promote liver metastasis. Jci Insight. 5. PMID 32879136 DOI: 10.1172/Jci.Insight.136215  0.405
2020 Bowers M, Liang T, Gonzalez-Bohorquez D, Zocher S, Jaeger BN, Kovacs WJ, Röhrl C, Cramb KML, Winterer J, Kruse M, Dimitrieva S, Overall RW, Wegleiter T, Najmabadi H, Semenkovich CF, et al. FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits. Cell Stem Cell. PMID 32386572 DOI: 10.1016/J.Stem.2020.04.002  0.38
2020 Wei X, Adak S, Zayed MA, Yin L, Feng C, Speck SL, Kathayat RS, Zhang Q, Dickinson BC, Semenkovich CF. Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease. Circulation Research. PMID 32233916 DOI: 10.1161/Circresaha.120.316752  0.304
2020 Dong G, Wei X, Yin L, Feng C, Adak S, Shyr ZA, Zhang Q, Morikawa S, Asada R, Urano F, Remedi MS, Semenkovich CF. 1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure Diabetes. 69. DOI: 10.2337/Db20-1789-P  0.334
2020 Tay S, Penrose A, Silva GSD, Yan Y, Semenkovich CF, Zayed MA. Circulating Fatty Acid Synthase and Diabetes Are Independently Associated With Chronic Limb-Threatening Ischemia Journal of Vascular Surgery. 72. DOI: 10.1016/J.Jvs.2020.04.245  0.328
2019 Bao YK, Yan Y, Wilson B, Gordon MO, Semenkovich CF, Rajagopal R. Association of Retinopathy and Insulin Resistance: NHANES 2005-2008. Current Eye Research. 1-4. PMID 31460803 DOI: 10.1080/02713683.2019.1659977  0.325
2019 McGill JB, Johnson M, Hurst S, Cade WT, Yarasheski KE, Ostlund RE, Schechtman KB, Razani B, Kastan MB, McClain DA, de Las Fuentes L, Davila-Roman VG, Ory DS, Wickline SA, Semenkovich CF. Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness. Diabetology & Metabolic Syndrome. 11: 61. PMID 31384309 DOI: 10.1186/S13098-019-0456-4  0.392
2019 De Silva GS, Desai K, Darwech M, Naim U, Jin X, Adak S, Harroun N, Sanchez LA, Semenkovich CF, Zayed MA. Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated. Atherosclerosis. 287: 38-45. PMID 31202106 DOI: 10.1016/J.Atherosclerosis.2019.05.016  0.356
2019 Dimas P, Montani L, Pereira JA, Moreno D, Trötzmüller M, Gerber J, Semenkovich CF, Köfeler HC, Suter U. CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes. Elife. 8. PMID 31063129 DOI: 10.7554/Elife.44702  0.31
2018 Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, ... ... Semenkovich CF, et al. Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. Cell Metabolism. PMID 30146486 DOI: 10.1016/J.Cmet.2018.07.019  0.368
2018 Montani L, Pereira JA, Norrmén C, Pohl HBF, Tinelli E, Trötzmüller M, Figlia G, Dimas P, von Niederhäusern B, Schwager R, Jessberger S, Semenkovich CF, Köfeler HC, Suter U. De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination. The Journal of Cell Biology. PMID 29434029 DOI: 10.1083/Jcb.201706010  0.39
2018 Rajagopal R, Zhang S, Wei X, Doggett T, Adak S, Enright J, Shah V, Ling G, Chen S, Yoshino J, Hsu FF, Semenkovich CF. Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. Jci Insight. 3. PMID 29321376 DOI: 10.1172/Jci.Insight.97076  0.381
2018 Desai KA, DeSilva G, Chao Y, Sanchez L, Semenkovich C, Zayed M. Abstract 331: Fatty Acid Synthase Expression in Peripheral Arterial Plaque Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.331  0.326
2018 Desai KA, DeSilva G, Yang C, Sanchez LA, Semenkovich CF, Zayed M. IP229. Fatty Acid Synthase Expression in Peripheral Arterial Journal of Vascular Surgery. 67: e146-e147. DOI: 10.1016/J.Jvs.2018.03.199  0.326
2018 De Silva GS, Desai KA, Semenkovich CF, Sanchez LA, Zayed MA. Circulating Fatty Acid Synthase Is a Novel Biomarker of Disease Severity in Patients with Peripheral Arterial Disease and Diabetes Journal of the American College of Surgeons. 227: S285-S286. DOI: 10.1016/J.Jamcollsurg.2018.07.590  0.313
2017 Lodhi IJ, Dean JM, He A, Park H, Tan M, Feng C, Song H, Hsu FF, Semenkovich CF. PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Cell Reports. 20: 2766-2774. PMID 28930673 DOI: 10.1016/J.Celrep.2017.08.077  0.418
2017 Guilherme A, Pedersen DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B, Jung D, Kim JK, Lodhi IJ, Semenkovich CF, Czech MP. Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming. Molecular Metabolism. 6: 781-796. PMID 28752043 DOI: 10.1016/J.Molmet.2017.05.012  0.432
2017 Clark AL, Kanekura K, Lavagnino Z, Spears LD, Abreu D, Mahadevan J, Yagi T, Semenkovich CF, Piston DW, Urano F. Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death. Scientific Reports. 7: 5611. PMID 28717166 DOI: 10.1038/S41598-017-05935-4  0.302
2017 Semenkovich CF. We Know More Than We Can Tell About Diabetes and Vascular Disease: The 2016 Edwin Bierman Award Lecture. Diabetes. 66: 1735-1741. PMID 28637825 DOI: 10.2337/Db17-0093  0.339
2017 Zayed MA, Wei X, Park KM, Belaygorod L, Naim U, Harvey J, Yin L, Blumer K, Semenkovich CF. N-Acetylcysteine accelerates amputation stump healing in the setting of diabetes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28280002 DOI: 10.1096/Fj.201601348R  0.307
2017 Lawson HA, Zayed M, Wayhart JP, Fabbrini E, Love-Gregory L, Klein S, Semenkovich CF. Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans. International Journal of Obesity (2005). PMID 28119529 DOI: 10.1038/Ijo.2017.19  0.406
2016 Wei X, Song H, Yin L, Rizzo MG, Sidhu R, Covey DF, Ory DS, Semenkovich CF. Fatty acid synthesis configures the plasma membrane for inflammation in diabetes. Nature. PMID 27806377 DOI: 10.1038/Nature20117  0.458
2016 Semenkovich CF. Insulin Resistance and a Long, Strange Trip. The New England Journal of Medicine. PMID 26886417 DOI: 10.1056/Nejme1600962  0.399
2016 Rajagopal R, Bligard GW, Zhang S, Yin L, Lukasiewicz P, Semenkovich CF. Functional Deficits Precede Structural Lesions in Mice with High-Fat Diet-Induced Diabetic Retinopathy. Diabetes. PMID 26740595 DOI: 10.2337/Db15-1255  0.425
2015 Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Diabetes. PMID 26512026 DOI: 10.2337/Db15-0659  0.405
2015 Li L, Pilo GM, Li X, Cigliano A, Latte G, Che L, Joseph C, Mela M, Wang C, Jiang L, Ribback S, Simile MM, Pascale RM, Dombrowski F, Evert M, ... Semenkovich CF, et al. Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans. Journal of Hepatology. PMID 26476289 DOI: 10.1016/J.Jhep.2015.10.004  0.359
2015 Izawa T, Rohatgi N, Fukunaga T, Wang QT, Silva MJ, Gardner MJ, McDaniel ML, Abumrad NA, Semenkovich CF, Teitelbaum SL, Zou W. ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis. Cell Reports. 11: 1625-37. PMID 26051940 DOI: 10.1016/J.Celrep.2015.05.019  0.4
2015 Lodhi IJ, Link DC, Semenkovich CF. Acute ether lipid deficiency affects neutrophil biology in mice. Cell Metabolism. 21: 652-3. PMID 25955199 DOI: 10.1016/J.Cmet.2015.04.018  0.34
2015 Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metabolism. 21: 51-64. PMID 25565205 DOI: 10.1016/J.Cmet.2014.12.002  0.429
2014 Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, et al. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. Proceedings of the National Academy of Sciences of the United States of America. 111: E5292-301. PMID 25422446 DOI: 10.1073/Pnas.1421055111  0.307
2014 Lodhi IJ, Semenkovich CF. Peroxisomes: a nexus for lipid metabolism and cellular signaling. Cell Metabolism. 19: 380-92. PMID 24508507 DOI: 10.1016/J.Cmet.2014.01.002  0.395
2014 Partridge CG, Fawcett GL, Wang B, Semenkovich CF, Cheverud JM. The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice. Bmc Genomics. 15: 99. PMID 24499025 DOI: 10.1186/1471-2164-15-99  0.43
2014 Wei X, Song H, Semenkovich CF. Insulin-regulated protein palmitoylation impacts endothelial cell function. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 346-54. PMID 24357059 DOI: 10.1161/Atvbaha.113.302848  0.37
2014 Rajagopal R, Semenkovich CF. Peroxisome proliferator activated receptor-δ: the middle child vies for attention. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 5-7. PMID 24335675 DOI: 10.1161/Atvbaha.113.302777  0.43
2013 Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (New York, N.Y.). 341: 1241214. PMID 24009397 DOI: 10.1126/Science.1241214  0.389
2013 Jensen-Urstad AP, Song H, Lodhi IJ, Funai K, Yin L, Coleman T, Semenkovich CF. Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα. Journal of Lipid Research. 54: 1848-59. PMID 23585690 DOI: 10.1194/Jlr.M036103  0.758
2013 Funai K, Song H, Yin L, Lodhi IJ, Wei X, Yoshino J, Coleman T, Semenkovich CF. Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. The Journal of Clinical Investigation. 123: 1229-40. PMID 23376793 DOI: 10.1172/Jci65726  0.415
2013 Knobloch M, Braun SM, Zurkirchen L, von Schoultz C, Zamboni N, Araúzo-Bravo MJ, Kovacs WJ, Karalay O, Suter U, Machado RA, Roccio M, Lutolf MP, Semenkovich CF, Jessberger S. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature. 493: 226-30. PMID 23201681 DOI: 10.1038/Nature11689  0.373
2013 Chen X, Li L, Wang C, Evert M, Calvisi DF, Semenkovich CF. Abstract 1880: Role of fatty acid synthase and do novo lipogenesis in liver cancer development in mice. Cancer Research. 73: 1880-1880. DOI: 10.1158/1538-7445.Am2013-1880  0.394
2012 Minkina O, Cheverud JM, Fawcett G, Semenkovich CF, Kenney-Hunt JP. Quantitative trait loci affecting liver fat content in mice. G3 (Bethesda, Md.). 2: 1019-25. PMID 22973538 DOI: 10.1534/G3.112.003343  0.399
2012 Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, Semenkovich CF. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Cell Metabolism. 16: 189-201. PMID 22863804 DOI: 10.1016/J.Cmet.2012.06.013  0.761
2012 Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF. Autophagy links inflammasomes to atherosclerotic progression. Cell Metabolism. 15: 534-44. PMID 22440612 DOI: 10.1016/J.Cmet.2012.02.011  0.352
2012 Wei X, Yang Z, Rey FE, Ridaura VK, Davidson NO, Gordon JI, Semenkovich CF. Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2. Cell Host & Microbe. 11: 140-52. PMID 22341463 DOI: 10.1016/J.Chom.2011.12.006  0.393
2012 Jensen-Urstad AP, Semenkovich CF. Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? Biochimica Et Biophysica Acta. 1821: 747-53. PMID 22009142 DOI: 10.1016/J.Bbalip.2011.09.017  0.752
2011 Lawson HA, Cady JE, Partridge C, Wolf JB, Semenkovich CF, Cheverud JM. Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations. Plos Genetics. 7: e1002256. PMID 21931559 DOI: 10.1371/Journal.Pgen.1002256  0.305
2011 Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, Semenkovich CF. Fatty acid synthase modulates homeostatic responses to myocardial stress. The Journal of Biological Chemistry. 286: 30949-61. PMID 21757749 DOI: 10.1074/Jbc.M111.230508  0.348
2011 Funai K, Semenkovich CF. Skeletal muscle lipid flux: running water carries no poison. American Journal of Physiology. Endocrinology and Metabolism. 301: E245-51. PMID 21558546 DOI: 10.1152/Ajpendo.00152.2011  0.383
2011 Lawson HA, Lee A, Fawcett GL, Wang B, Pletscher LS, Maxwell TJ, Ehrich TH, Kenney-Hunt JP, Wolf JB, Semenkovich CF, Cheverud JM. The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 22: 197-208. PMID 21210123 DOI: 10.1007/S00335-010-9313-3  0.324
2011 Wei X, Schneider JG, Shenouda SM, Lee A, Towler DA, Chakravarthy MV, Vita JA, Semenkovich CF. De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation. The Journal of Biological Chemistry. 286: 2933-45. PMID 21098489 DOI: 10.1074/Jbc.M110.193037  0.421
2011 Lodhi IJ, Wei X, Semenkovich CF. Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter. Trends in Endocrinology and Metabolism: Tem. 22: 1-8. PMID 20889351 DOI: 10.1016/J.Tem.2010.09.002  0.409
2011 Cheverud JM, Lawson HA, Fawcett GL, Wang B, Pletscher LS, R Fox A, Maxwell TJ, Ehrich TH, Kenney-Hunt JP, Wolf JB, Semenkovich CF. Diet-dependent genetic and genomic imprinting effects on obesity in mice. Obesity (Silver Spring, Md.). 19: 160-70. PMID 20539295 DOI: 10.1038/Oby.2010.141  0.335
2010 Yu C, Jiang S, Lu J, Coughlin CC, Wang Y, Swietlicki EA, Wang L, Vietor I, Huber LA, Cikes D, Coleman T, Xie Y, Semenkovich CF, Davidson NO, Levin MS, et al. Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection. The Journal of Nutrition. 140: 1907-14. PMID 20861213 DOI: 10.3945/Jn.110.127084  0.415
2010 Lawson HA, Zelle KM, Fawcett GL, Wang B, Pletscher LS, Maxwell TJ, Ehrich TH, Kenney-Hunt JP, Wolf JB, Semenkovich CF, Cheverud JM. Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model. Journal of Lipid Research. 51: 2976-84. PMID 20601649 DOI: 10.1194/Jlr.M006957  0.348
2010 Schneider JG, Yang Z, Chakravarthy MV, Lodhi IJ, Wei X, Turk J, Semenkovich CF. Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis. The Journal of Biological Chemistry. 285: 23398-409. PMID 20479009 DOI: 10.1074/Jbc.M110.100321  0.474
2010 Cheverud JM, Fawcett GL, Jarvis JP, Norgard EA, Pavlicev M, Pletscher LS, Polonsky KS, Ye H, Bell GI, Semenkovich CF. Calpain-10 is a component of the obesity-related quantitative trait locus Adip1. Journal of Lipid Research. 51: 907-13. PMID 20388922 DOI: 10.1194/Jlr.M900128  0.36
2010 Razani B, Feng C, Semenkovich CF. p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. Journal of Lipid Research. 51: 1738-46. PMID 20208057 DOI: 10.1194/Jlr.M003681  0.41
2010 Song H, Wohltmann M, Bao S, Ladenson JH, Semenkovich CF, Turk J. Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet. American Journal of Physiology. Endocrinology and Metabolism. 298: E1097-114. PMID 20179248 DOI: 10.1152/Ajpendo.00780.2009  0.476
2009 Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell. 138: 476-88. PMID 19646743 DOI: 10.1016/J.Cell.2009.05.036  0.393
2009 Razani B, Semenkovich CF. Getting away from glucose: stop sugarcoating diabetes. Nature Medicine. 15: 372-3. PMID 19350008 DOI: 10.1038/Nm0409-372  0.324
2009 Lodhi IJ, Semenkovich CF. Why we should put clothes on mice. Cell Metabolism. 9: 111-2. PMID 19187768 DOI: 10.1016/J.Cmet.2009.01.004  0.363
2009 Chakravarthy MV, Zhu Y, Yin L, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. Journal of Lipid Research. 50: 630-40. PMID 19029118 DOI: 10.1194/Jlr.M800379-Jlr200  0.493
2008 Razani B, Chakravarthy MV, Semenkovich CF. Insulin resistance and atherosclerosis. Endocrinology and Metabolism Clinics of North America. 37: 603-21, viii. PMID 18775354 DOI: 10.1016/J.Ecl.2008.05.001  0.361
2008 Newberry EP, Kennedy SM, Xie Y, Luo J, Stanley SE, Semenkovich CF, Crooke RM, Graham MJ, Davidson NO. Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology (Baltimore, Md.). 48: 1097-105. PMID 18697204 DOI: 10.1002/Hep.22473  0.403
2008 Proctor BM, Jin X, Lupu TS, Muglia LJ, Semenkovich CF, Muslin AJ. Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury. Circulation. 118: 658-66. PMID 18645058 DOI: 10.1161/Circulationaha.107.734848  0.349
2008 Chakravarthy MV, Zhu Y, Wice MB, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF. Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age. Diabetes. 57: 2698-707. PMID 18591393 DOI: 10.2337/Db08-0404  0.384
2008 Zhang JR, Coleman T, Langmade SJ, Scherrer DE, Lane L, Lanier MH, Feng C, Sands MS, Schaffer JE, Semenkovich CF, Ory DS. Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. The Journal of Clinical Investigation. 118: 2281-90. PMID 18483620 DOI: 10.1172/Jci32561  0.421
2007 Gates AC, Bernal-Mizrachi C, Chinault SL, Feng C, Schneider JG, Coleman T, Malone JP, Townsend RR, Chakravarthy MV, Semenkovich CF. Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metabolism. 6: 497-505. PMID 18054318 DOI: 10.1016/J.Cmet.2007.10.010  0.359
2007 Schneider JG, Zhu Y, Coleman T, Semenkovich CF. Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 2699-706. PMID 17951320 DOI: 10.1161/Atvbaha.107.153650  0.382
2007 Woloszynek JC, Coleman T, Semenkovich CF, Sands MS. Lysosomal dysfunction results in altered energy balance. The Journal of Biological Chemistry. 282: 35765-71. PMID 17911106 DOI: 10.1074/Jbc.M705124200  0.47
2007 Tordjman KM, Semenkovich CF, Coleman T, Yudovich R, Bak S, Osher E, Vechoropoulos M, Stern N. Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse. Hypertension. 50: 945-51. PMID 17909121 DOI: 10.1161/Hypertensionaha.107.094268  0.325
2007 Gustafsson M, Levin M, Skålén K, Perman J, Fridén V, Jirholt P, Olofsson SO, Fazio S, Linton MF, Semenkovich CF, Olivecrona G, Borén J. Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase. Circulation Research. 101: 777-83. PMID 17761930 DOI: 10.1161/Circresaha.107.149666  0.376
2007 Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 116: 1404-12. PMID 17724261 DOI: 10.1161/Circulationaha.106.684704  0.392
2007 Chakravarthy MV, Zhu Y, López M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF. Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. The Journal of Clinical Investigation. 117: 2539-52. PMID 17694178 DOI: 10.1172/Jci31183  0.487
2007 Semenkovich CF, Teitelbaum SL. Bone weighs in on obesity. Cell. 130: 409-11. PMID 17693252 DOI: 10.1016/J.Cell.2007.07.031  0.375
2007 Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J. Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2. The Journal of Biological Chemistry. 282: 27100-14. PMID 17627946 DOI: 10.1074/Jbc.M701316200  0.357
2007 Proctor BM, Ren J, Chen Z, Schneider JG, Coleman T, Lupu TS, Semenkovich CF, Muslin AJ. Grb2 is required for atherosclerotic lesion formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1361-7. PMID 17363695 DOI: 10.1161/Atvbaha.106.134007  0.409
2007 Chakravarthy MV, Semenkovich CF. The ABCs of beta-cell dysfunction in type 2 diabetes. Nature Medicine. 13: 241-2. PMID 17342111 DOI: 10.1038/Nm0307-241  0.367
2007 Bernal-Mizrachi C, Xiaozhong L, Yin L, Knutsen RH, Howard MJ, Arends JJ, Desantis P, Coleman T, Semenkovich CF. An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension. Cell Metabolism. 5: 91-102. PMID 17276352 DOI: 10.1016/J.Cmet.2006.12.010  0.406
2007 Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 979-84. PMID 17210919 DOI: 10.1073/Pnas.0605374104  0.485
2006 Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, Bernal-Mizrachi C, Muslin AJ, Kastan MB, Semenkovich CF. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metabolism. 4: 377-89. PMID 17084711 DOI: 10.1016/J.Cmet.2006.10.002  0.767
2006 Subramanian S, DeRosa MA, Bernal-Mizrachi C, Laffely N, Cade WT, Yarasheski KE, Cryer PE, Semenkovich CF. PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans. American Journal of Physiology. Endocrinology and Metabolism. 291: E1365-71. PMID 16868225 DOI: 10.1152/Ajpendo.00230.2006  0.363
2006 Semenkovich CF. Insulin resistance and atherosclerosis. The Journal of Clinical Investigation. 116: 1813-22. PMID 16823479 DOI: 10.1172/Jci29024  0.376
2005 Schneider JG, Semenkovich CF. PPARalpha: savior or savage? Cell Metabolism. 2: 341-2. PMID 16330317 DOI: 10.1016/J.Cmet.2005.11.006  0.3
2005 Wang Y, Iordanov H, Swietlicki EA, Wang L, Fritsch C, Coleman T, Semenkovich CF, Levin MS, Rubin DC. Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity. The Journal of Biological Chemistry. 280: 34764-75. PMID 16085642 DOI: 10.1074/Jbc.M507058200  0.444
2005 Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metabolism. 1: 309-22. PMID 16054078 DOI: 10.1016/J.Cmet.2005.04.002  0.488
2005 Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metabolism. 1: 133-44. PMID 16054054 DOI: 10.1016/J.Cmet.2005.01.006  0.472
2005 Ehrich TH, Hrbek T, Kenney-Hunt JP, Pletscher LS, Wang B, Semenkovich CF, Cheverud JM. Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes. 54: 1863-72. PMID 15919810 DOI: 10.2337/Diabetes.54.6.1863  0.37
2005 Bernal-Mizrachi C, Gates AC, Weng S, Imamura T, Knutsen RH, DeSantis P, Coleman T, Townsend RR, Muglia LJ, Semenkovich CF. Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature. 435: 502-6. PMID 15917810 DOI: 10.1038/Nature03527  0.375
2005 Chaparro J, Reeds DN, Wen W, Xueping E, Klein S, Semenkovich CF, Bae KT, Quirk EK, Powderly WG, Yarasheski KE, Li E. Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy. Metabolism: Clinical and Experimental. 54: 561-7. PMID 15877283 DOI: 10.1016/J.Metabol.2004.08.022  0.302
2005 Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, ... ... Semenkovich CF, et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. Plos Biology. 3: e101. PMID 15760270 DOI: 10.1371/Journal.Pbio.0030101  0.331
2005 Pappan KL, Pan Z, Kwon G, Marshall CA, Coleman T, Goldberg IJ, McDaniel ML, Semenkovich CF. Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion. The Journal of Biological Chemistry. 280: 9023-9. PMID 15637076 DOI: 10.1074/Jbc.M409706200  0.437
2004 Cheverud JM, Ehrich TH, Hrbek T, Kenney JP, Pletscher LS, Semenkovich CF. Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 53: 3328-36. PMID 15561968 DOI: 10.2337/Diabetes.53.12.3328  0.344
2004 Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences of the United States of America. 101: 15718-23. PMID 15505215 DOI: 10.1073/Pnas.0407076101  0.405
2004 Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 53: 2700-8. PMID 15448104 DOI: 10.2337/Diabetes.53.10.2700  0.366
2004 Semenkovich CF. Fatty acid metabolism and vascular disease. Trends in Cardiovascular Medicine. 14: 72-6. PMID 15030793 DOI: 10.1016/J.Tcm.2003.12.004  0.452
2004 Woloszynek JC, Roberts M, Coleman T, Vogler C, Sly W, Semenkovich CF, Sands MS. Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII. The Biochemical Journal. 379: 461-9. PMID 14705966 DOI: 10.1042/Bj20031048  0.381
2004 Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care. 27: 256-63. PMID 14693998 DOI: 10.2337/Diacare.27.1.256  0.311
2004 Han DH, Nolte LA, Ju JS, Coleman T, Holloszy JO, Semenkovich CF. UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. American Journal of Physiology. Endocrinology and Metabolism. 286: E347-53. PMID 14613927 DOI: 10.1152/Ajpendo.00434.2003  0.374
2004 Liu Y, Robert M, Xu L, Novack D, Semenkovich C, Coleman T, Ponder K. 856. Neonatal Liver-Directed Gene Therapy Markedly Reduces Bone Disease in MPS I Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.764  0.324
2003 Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003. Circulation. 108: 2941-8. PMID 14662691 DOI: 10.1161/01.Cir.0000103683.99399.7E  0.311
2003 Grenache DG, Coleman T, Semenkovich CF, Santoro SA, Zutter MM. Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 2104-9. PMID 14512368 DOI: 10.1161/01.Atv.0000097282.22923.Ef  0.336
2003 Baar K, Song Z, Semenkovich CF, Jones TE, Han DH, Nolte LA, Ojuka EO, Chen M, Holloszy JO. Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1666-73. PMID 12958173 DOI: 10.1096/Fj.03-0049Com  0.35
2003 Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nature Medicine. 9: 1069-75. PMID 12847522 DOI: 10.1038/Nm898  0.416
2003 Hensley LL, Ranganathan G, Wagner EM, Wells BD, Daniel JC, Vu D, Semenkovich CF, Zechner R, Kern PA. Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation. The Journal of Biological Chemistry. 278: 32702-9. PMID 12796491 DOI: 10.1074/Jbc.M304200200  0.452
2003 Weng S, Zemany L, Standley KN, Novack DV, La Regina M, Bernal-Mizrachi C, Coleman T, Semenkovich CF. Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 6730-5. PMID 12746502 DOI: 10.1073/Pnas.1137612100  0.748
2003 Chen Z, Fitzgerald RL, Saffitz JE, Semenkovich CF, Schonfeld G. Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 668-74. PMID 12615667 DOI: 10.1161/01.Atv.0000062701.02853.Ae  0.306
2002 Bidder M, Shao JS, Charlton-Kachigian N, Loewy AP, Semenkovich CF, Towler DA. Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities. The Journal of Biological Chemistry. 277: 44485-96. PMID 12200434 DOI: 10.1074/Jbc.M206235200  0.362
2002 Bernal-Mizrachi C, Weng S, Li B, Nolte LA, Feng C, Coleman T, Holloszy JO, Semenkovich CF. Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 961-8. PMID 12067905 DOI: 10.1161/01.Atv.0000019404.65403.71  0.424
2002 Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP, Semenkovich CF. PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. Journal of Lipid Research. 43: 936-43. PMID 12032169  0.77
2001 Bergeron R, Ren JM, Cadman KS, Moore IK, Perret P, Pypaert M, Young LH, Semenkovich CF, Shulman GI. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. American Journal of Physiology. Endocrinology and Metabolism. 281: E1340-6. PMID 11701451 DOI: 10.1152/Ajpendo.2001.281.6.E1340  0.34
2001 Greiwe JS, Kwon G, McDaniel ML, Semenkovich CF. Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 281: E466-71. PMID 11500301 DOI: 10.1152/Ajpendo.2001.281.3.E466  0.36
2001 Polonsky KS, Semenkovich CF. The pancreatic β cell heats up: UCP2 and insulin secretion in diabetes Cell. 105: 705-707. PMID 11440712 DOI: 10.1016/S0092-8674(01)00389-0  0.302
2001 Cruz WS, Kwon G, Marshall CA, McDaniel ML, Semenkovich CF. Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction. The Journal of Biological Chemistry. 276: 12162-8. PMID 11154699 DOI: 10.1074/Jbc.M010707200  0.418
2001 Tordjman K, Bernal-Mizrachi C, Zemany L, Weng S, Feng C, Zhang F, Leone TC, Coleman T, Kelly DP, Semenkovich CF. PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice Journal of Clinical Investigation. 107: 1025-1034. DOI: 10.1172/Jci11497  0.456
2000 Li B, Nolte LA, Ju JS, Dong Ho Han, Coleman T, Holloszy JO, Semenkovich CF. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice Nature Medicine. 6: 1115-1120. PMID 11017142 DOI: 10.1038/80450  0.436
1999 Marshall BA, Tordjman K, Host HH, Ensor NJ, Kwon G, Marshall CA, Coleman T, McDaniel ML, Semenkovich CF. Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion. The Journal of Biological Chemistry. 274: 27426-32. PMID 10488074 DOI: 10.1074/Jbc.274.39.27426  0.435
1999 Babaev VR, Fazio S, Gleaves LA, Carter KJ, Semenkovich CF, Linton MF. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo Journal of Clinical Investigation. 103: 1697-1705. PMID 10377176 DOI: 10.1172/Jci6117  0.414
1999 Li B, Holloszy JO, Semenkovich CF. Respiratory uncoupling induces δ-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells Journal of Biological Chemistry. 274: 17534-17540. PMID 10364186 DOI: 10.1074/Jbc.274.25.17534  0.331
1998 Towler DA, Bidder M, Latifi T, Coleman T, Semenkovich CF. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice Journal of Biological Chemistry. 273: 30427-30434. PMID 9804809 DOI: 10.1074/Jbc.273.46.30427  0.441
1998 Li Q, Chua MS, Semenkovich CF. Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein American Journal of Physiology - Endocrinology and Metabolism. 274. PMID 9575816 DOI: 10.1152/Ajpendo.1998.274.4.E577  0.341
1997 Excoffon KJ, Liu G, Miao L, Wilson JE, McManus BM, Semenkovich CF, Coleman T, Benoit P, Duverger N, Branellec D, Denefle P, Hayden MR, Lewis ME. Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 2532-9. PMID 9409224 DOI: 10.1161/01.Atv.17.11.2532  0.407
1997 Semenkovich CF. Regulation of fatty acid synthase (FAS) Progress in Lipid Research. 36: 43-53. PMID 9373620 DOI: 10.1016/S0163-7827(97)00003-9  0.375
1997 Semenkovich CF, Heinecke JW. The mystery of diabetes and atherosclerosis: time for a new plot. Diabetes. 46: 327-34. PMID 9032085 DOI: 10.2337/Diab.46.3.327  0.324
1995 Seip RL, Angelopoulos TJ, Semenkovich CF. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue American Journal of Physiology - Endocrinology and Metabolism. 268. PMID 7864098 DOI: 10.1152/Ajpendo.1995.268.2.E229  0.303
1995 Coleman T, Seip RL, Gimble JM, Lee D, Maeda N, Semenkovich CF. COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity Journal of Biological Chemistry. 270: 12518-12525. PMID 7759497 DOI: 10.1074/Jbc.270.21.12518  0.376
1995 Dudek SM, Semenkovich CF. Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism. The Journal of Biological Chemistry. 270: 29323-9. PMID 7493965 DOI: 10.1074/Jbc.270.49.29323  0.395
1993 Ren JM, Semenkovich CF, Holloszy JO. Adaptation of muscle to creatine depletion: Effect on GLUT-4 glucose transporter expression American Journal of Physiology - Cell Physiology. 264. PMID 8430763 DOI: 10.1152/Ajpcell.1993.264.1.C146  0.334
1989 Ostlund RE, Semenkovich CF, Schechtman KB. Quantitative relationship between plasma lipids and glycohemoglobin in type 1 patients: Longitudinal study of 212 patients Diabetes Care. 12: 332-336. PMID 2721341 DOI: 10.2337/Diacare.12.5.332  0.342
1989 Semenkovich CF, Ostlund RE, Schechtman KB. Plasma Lipids in Patients With Type I Diabetes Mellitus: Influence of Race, Gender, and Plasma Glucose Control: Lipids Do Not Correlate With Glucose Control in Black Women Archives of Internal Medicine. 149: 51-56. PMID 2643418 DOI: 10.1001/Archinte.1989.00390010069006  0.315
1987 Semenkovich CF, Ostlund RE. Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line hep G2 Biochemistry. 26: 4987-4992. PMID 2822102 DOI: 10.1021/Bi00390A016  0.328
1986 Levy RA, Ostlund RE, Semenkovich CF, Witztum JL. Diversity in expression of heterozygous familial hypercholesterolemia. Characterization of a unique kindred Journal of Clinical Investigation. 78: 96-101. PMID 3722389 DOI: 10.1172/Jci112579  0.324
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