Eric V. Shusta - Publications

Affiliations: 
University of Wisconsin, Madison, Madison, WI 
Area:
Chemical Engineering, Microbiology Biology

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Year Citation  Score
2024 McCloskey MC, Ahmad SD, Widom LP, Kasap P, Gastfriend BD, Shusta EV, Palecek SP, Engelhardt B, Gaborski TR, Flax J, Waugh RE, McGrath JL. Pericytes Enrich the Basement Membrane and Reduce Neutrophil Transmigration in an In Vitro Model of Peripheral Inflammation at the Blood-Brain Barrier. Biomaterials Research. 28: 0081. PMID 39363889 DOI: 10.34133/bmr.0081  0.33
2024 Gastfriend BD, Snyder ME, Holt HE, Daneman R, Palecek SP, Shusta EV. Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest. Science Advances. 10: eadi1737. PMID 38306433 DOI: 10.1126/sciadv.adi1737  0.34
2023 Choi ES, Shusta EV. Strategies to identify, engineer, and validate antibodies targeting blood-brain barrier receptor-mediated transcytosis systems for CNS drug delivery. Expert Opinion On Drug Delivery. 1-12. PMID 38007619 DOI: 10.1080/17425247.2023.2286371  0.323
2023 Foreman KL, Shusta EV, Palecek SP. Defined Differentiation of Human Pluripotent Stem Cells to Brain Microvascular Endothelial-Like Cells for Modeling the Blood-Brain Barrier. Methods in Molecular Biology (Clifton, N.J.). 2683: 113-133. PMID 37300771 DOI: 10.1007/978-1-0716-3287-1_10  0.362
2022 Georgieva JV, Katt M, Ye Z, Umlauf BJ, Wenthur CJ, Shusta EV. The 46.1 Antibody Mediates Neurotensin Uptake into the CNS and the Effects Depend on the Route of Intravenous Administration. Pharmaceutics. 14. PMID 36015332 DOI: 10.3390/pharmaceutics14081706  0.345
2022 Lajoie JM, Katt ME, Waters EA, Herrin BR, Shusta EV. Identification of lamprey variable lymphocyte receptors that target the brain vasculature. Scientific Reports. 12: 6044. PMID 35411012 DOI: 10.1038/s41598-022-09962-8  0.352
2022 Ye Z, Gastfriend BD, Umlauf BJ, Lynn DM, Shusta EV. Antibody-Targeted Liposomes for Enhanced Targeting of the Blood-Brain Barrier. Pharmaceutical Research. PMID 35169958 DOI: 10.1007/s11095-022-03186-1  0.326
2021 Ding Y, Shusta EV, Palecek SP. Integrating in vitro disease models of the neurovascular unit into discovery and development of neurotherapeutics. Current Opinion in Biomedical Engineering. 20. PMID 34693102 DOI: 10.1016/j.cobme.2021.100341  0.33
2021 Nishihara H, Gastfriend BD, Kasap P, Palecek SP, Shusta EV, Engelhardt B. Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions. Star Protocols. 2: 100563. PMID 34151293 DOI: 10.1016/j.xpro.2021.100563  0.306
2021 Gastfriend BD, Foreman KL, Katt ME, Palecek SP, Shusta EV. Integrative analysis of the human brain mural cell transcriptome. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X211013700. PMID 34027687 DOI: 10.1177/0271678X211013700  0.318
2021 Gastfriend BD, Stebbins MJ, Du F, Shusta EV, Palecek SP. Differentiation of Brain Pericyte-Like Cells from Human Pluripotent Stem Cell-Derived Neural Crest. Current Protocols. 1: e21. PMID 33484491 DOI: 10.1002/cpz1.21  0.337
2020 Nishihara H, Gastfriend BD, Soldati S, Perriot S, Mathias A, Sano Y, Shimizu F, Gosselet F, Kanda T, Palecek SP, Du Pasquier R, Shusta EV, Engelhardt B. Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 33124083 DOI: 10.1096/fj.202001507RR  0.323
2020 Lippmann ES, Azarin SM, Palecek SP, Shusta EV. Commentary on human pluripotent stem cell-based blood-brain barrier models. Fluids and Barriers of the Cns. 17: 64. PMID 33076946 DOI: 10.1186/s12987-020-00222-3  0.671
2020 Georgieva JV, Goulatis LI, Stutz CC, Canfield SG, Song HW, Gastfriend BD, Shusta EV. Antibody screening using a human iPSC-based blood-brain barrier model identifies antibodies that accumulate in the CNS. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 34: 12549-12564. PMID 32960493 DOI: 10.1096/Fj.202000851R  0.488
2020 Katt ME, Shusta EV. Models of the Blood-Brain Barrier: Building in physiological complexity. Current Opinion in Chemical Engineering. 30: 42-52. PMID 32905326 DOI: 10.1016/J.Coche.2020.07.002  0.381
2020 Song HW, Foreman KL, Gastfriend BD, Kuo JS, Palecek SP, Shusta EV. Transcriptomic comparison of human and mouse brain microvessels. Scientific Reports. 10: 12358. PMID 32704093 DOI: 10.1038/S41598-020-69096-7  0.425
2020 Umlauf BJ, Shusta EV. Site-Directed Modification of Yeast-Produced Proteins Using Expressed Protein Ligation. Methods in Molecular Biology (Clifton, N.J.). 2133: 221-233. PMID 32144670 DOI: 10.1007/978-1-0716-0434-2_11  0.348
2019 Lajoie JM, Cho YK, Frost D, Bremner S, Li L, Shusta EV. A yeast display immunoprecipitation screen for targeted discovery of antibodies against membrane protein complexes. Protein Engineering, Design & Selection : Peds. PMID 31769480 DOI: 10.1093/Protein/Gzz035  0.427
2019 Kim BJ, McDonagh MA, Deng L, Gastfriend BD, Schubert-Unkmeir A, Doran KS, Shusta EV. Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells. Fluids and Barriers of the Cns. 16: 26. PMID 31434575 DOI: 10.1186/S12987-019-0146-5  0.374
2019 Canfield SG, Stebbins MJ, Faubion MG, Gastfriend BD, Palecek SP, Shusta EV. An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons. Fluids and Barriers of the Cns. 16: 25. PMID 31387594 DOI: 10.1186/S12987-019-0145-6  0.428
2019 Kim BJ, Shusta EV, Doran KS. Past and Current Perspectives in Modeling Bacteria and Blood-Brain Barrier Interactions. Frontiers in Microbiology. 10: 1336. PMID 31263460 DOI: 10.3389/Fmicb.2019.01336  0.398
2019 Park TE, Mustafaoglu N, Herland A, Hasselkus R, Mannix R, FitzGerald EA, Prantil-Baun R, Watters A, Henry O, Benz M, Sanchez H, McCrea HJ, Goumnerova LC, Song HW, Palecek SP, ... Shusta E, et al. Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies. Nature Communications. 10: 2621. PMID 31197168 DOI: 10.1038/S41467-019-10588-0  0.477
2019 Martins Gomes SF, Westermann AJ, Sauerwein T, Hertlein T, Förstner KU, Ohlsen K, Metzger M, Shusta EV, Kim BJ, Appelt-Menzel A, Schubert-Unkmeir A. Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Infection. Frontiers in Microbiology. 10: 1181. PMID 31191497 DOI: 10.3389/Fmicb.2019.01181  0.415
2019 Bradley RA, Shireman J, McFalls C, Choi J, Canfield SG, Dong Y, Liu K, Lisota B, Jones JR, Petersen A, Bhattacharyya A, Palecek SP, Shusta EV, Kendziorski C, Zhang SC. Regionally specified human pluripotent stem cell-derived astrocytes exhibit different molecular signatures and functional properties. Development (Cambridge, England). PMID 31189664 DOI: 10.1242/Dev.170910  0.369
2019 Umlauf BJ, Clark PA, Lajoie JM, Georgieva JV, Bremner S, Herrin BR, Kuo JS, Shusta EV. Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix. Science Advances. 5: eaau4245. PMID 31106264 DOI: 10.1126/Sciadv.Aau4245  0.412
2019 Stebbins MJ, Gastfriend BD, Canfield SG, Lee MS, Richards D, Faubion MG, Li WJ, Daneman R, Palecek SP, Shusta EV. Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties. Science Advances. 5: eaau7375. PMID 30891496 DOI: 10.1126/Sciadv.Aau7375  0.342
2019 Umlauf BJ, Shusta EV. Exploiting BBB disruption for the delivery of nanocarriers to the diseased CNS. Current Opinion in Biotechnology. 60: 146-152. PMID 30849699 DOI: 10.1016/J.Copbio.2019.01.013  0.362
2019 Qian T, Hernday SE, Bao X, Olson WR, Panzer SE, Shusta EV, Palecek SP. Directed Differentiation of Human Pluripotent Stem Cells to Podocytes under Defined Conditions. Scientific Reports. 9: 2765. PMID 30808965 DOI: 10.1038/S41598-019-39504-8  0.362
2019 Umlauf B, Clark P, Lajoie J, Georgieva J, Bremner S, Herrin B, Shusta E, Kuo J. EXTH-67. IDENTIFICATION AND DEVELOPMENT OF NEURAL ECM-BINDING LAMPREY ANTIBODIES (VARIABLE LYMPHOCYTE RECEPTORS) THAT TARGET GLIOBLASTOMA Neuro-Oncology. 21: vi96-vi96. DOI: 10.1093/Neuonc/Noz175.397  0.397
2018 Stutz CC, Georgieva JV, Shusta EV. Coupling Brain Perfusion Screens and Next Generation Sequencing to Identify Blood-Brain Barrier Binding Antibodies. Aiche Journal. American Institute of Chemical Engineers. 64: 4229-4236. PMID 30872841 DOI: 10.1002/Aic.16360  0.433
2018 Goulatis LI, Ramanathan R, Shusta EV. Impacts of the -1 Amino Acid on Yeast Production of Protein-Intein Fusions. Biotechnology Progress. PMID 30341810 DOI: 10.1002/Btpr.2736  0.341
2018 Gastfriend BD, Palecek SP, Shusta EV. Modeling the blood-brain barrier: Beyond the endothelial cells. Current Opinion in Biomedical Engineering. 5: 6-12. PMID 29915815 DOI: 10.1016/J.Cobme.2017.11.002  0.443
2018 Al-Ahmad AJ, Patel R, Palecek SP, Shusta EV. Hyaluronan impairs the barrier integrity of brain microvascular endothelial cell through a CD44-dependent pathway. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18767748. PMID 29589805 DOI: 10.1177/0271678X18767748  0.743
2018 Clark PA, Umlauf BJ, Shusta EV, Kuo JS. Abstract 1764: Neurovascular-targeting antibodies discovered using yeast biopanning enhance drug delivery and improve survival for glioblastoma Cancer Research. 78: 1764-1764. DOI: 10.1158/1538-7445.Am2018-1764  0.427
2017 Zorniak M, Clark PA, Umlauf BJ, Cho Y, Shusta EV, Kuo JS. Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells. Scientific Reports. 7: 15840. PMID 29158489 DOI: 10.1038/S41598-017-16066-1  0.773
2017 Qian T, Maguire SE, Canfield SG, Bao X, Olson WR, Shusta EV, Palecek SP. Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells. Science Advances. 3: e1701679. PMID 29134197 DOI: 10.1126/sciadv.1701679  0.358
2017 Kim BJ, Bee OB, McDonagh MA, Stebbins MJ, Palecek SP, Doran KS, Shusta EV. Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells. Msphere. 2. PMID 29104935 DOI: 10.1128/mSphere.00398-17  0.301
2017 Stebbins MJ, Lippmann ES, Faubion MG, Daneman R, Palecek SP, Shusta EV. Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells. Biotechnology Journal. PMID 28960887 DOI: 10.1002/Biot.201700093  0.677
2017 Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, ... ... Shusta EV, et al. Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier. Cell Stem Cell. PMID 28526555 DOI: 10.1016/J.Stem.2017.04.002  0.713
2016 Goulatis LI, Shusta EV. Protein engineering approaches for regulating blood-brain barrier transcytosis. Current Opinion in Structural Biology. 45: 109-115. PMID 28040636 DOI: 10.1016/J.Sbi.2016.12.005  0.432
2016 Canfield SG, Stebbins MJ, Morales BS, Asai SW, Vatine GD, Svendsen CN, Palecek SP, Shusta EV. An Isogenic Blood-Brain Barrier Model Comprising Brain Endothelial Cells, Astrocytes and Neurons Derived from Human Induced Pluripotent Stem Cells. Journal of Neurochemistry. PMID 27935037 DOI: 10.1111/Jnc.13923  0.417
2016 Wilson HK, Faubion MG, Hjortness MK, Palecek SP, Shusta EV. Cryopreservation of brain endothelial cells derived from human induced pluripotent stem cells is enhanced by ROCK inhibition. Tissue Engineering. Part C, Methods. PMID 27846787 DOI: 10.1089/Ten.Tec.2016.0345  0.468
2016 Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV. Analysis of Cancer-targeting Alkylphosphocholine Analog Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Molecular Pharmaceutics. PMID 27421304 DOI: 10.1021/Acs.Molpharmaceut.6B00441  0.743
2016 Helms HC, Abbott NJ, Burek M, Cecchelli R, Couraud PO, Deli MA, Förster C, Galla HJ, Romero IA, Shusta EV, Stebbins MJ, Vandenhaute E, Weksler B, Brodin B. In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26868179 DOI: 10.1177/0271678X16630991  0.427
2015 Tillotson BJ, Goulatis LI, Parenti I, Duxbury E, Shusta EV. Engineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular Accumulation. Plos One. 10: e0145820. PMID 26713870 DOI: 10.1371/Journal.Pone.0145820  0.77
2015 Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan JR, Shusta EV. Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor. Biotechnology Journal. PMID 26580314 DOI: 10.1002/Biot.201500360  0.364
2015 Stebbins MJ, Wilson HK, Canfield SG, Qian T, Palecek SP, Shusta EV. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Methods (San Diego, Calif.). PMID 26518252 DOI: 10.1016/J.Ymeth.2015.10.016  0.466
2015 Qian T, Shusta EV, Palecek SP. Advances in microfluidic platforms for analyzing and regulating human pluripotent stem cells. Current Opinion in Genetics & Development. 34: 54-60. PMID 26313850 DOI: 10.1016/J.Gde.2015.07.007  0.335
2015 Tillotson BJ, Lajoie JM, Shusta EV. Yeast Display-Based Antibody Affinity Maturation Using Detergent-Solubilized Cell Lysates. Methods in Molecular Biology (Clifton, N.J.). 1319: 65-78. PMID 26060070 DOI: 10.1007/978-1-4939-2748-7_4  0.798
2015 Wilson HK, Canfield SG, Hjortness MK, Palecek SP, Shusta EV. Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells. Fluids and Barriers of the Cns. 12: 13. PMID 25994964 DOI: 10.1186/S12987-015-0007-9  0.422
2015 Marshall CJ, Grosskopf VA, Moehling TJ, Tillotson BJ, Wiepz GJ, Abbott NL, Raines RT, Shusta EV. An evolved Mxe GyrA intein for enhanced production of fusion proteins. Acs Chemical Biology. 10: 527-38. PMID 25384269 DOI: 10.1021/Cb500689G  0.8
2015 Lajoie JM, Shusta EV. Introducing glycophage arrays: facile production, purification and patterning of glycophages. Biotechnology Journal. 10: 20-1. PMID 25359621 DOI: 10.1002/Biot.201400591  0.308
2015 Lajoie JM, Shusta EV. Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier. Annual Review of Pharmacology and Toxicology. 55: 613-31. PMID 25340933 DOI: 10.1146/Annurev-Pharmtox-010814-124852  0.394
2015 Clark P, Al-Ahmad A, Qian T, Zhang R, Jeffery J, Wilson H, Palecek S, Weichert J, Shusta E, Kuo J. DDEL-05DIFFERENTIAL BLOOD-BRAIN BARRIER (BBB) PERMEABILITY OF ALKYLPHOSPHOCHOLINE (APC) ANALOGS ANALYZED USING AN IN VITRO PLURIPOTENT STEM CELL-DERIVED BRAIN MICROVASCULAR ENDOTHELIAL CELL SYSTEM Neuro-Oncology. 17: v74.1-v74. DOI: 10.1093/Neuonc/Nov212.05  0.741
2015 Lian X, Bao X, Al-Ahmad A, Liu J, Wu Y, Dong W, Dunn KK, Shusta EV, Palecek SP. Erratum: Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling (Stem Cell Reports (2014) 3 (804-816)) Stem Cell Reports. 4. DOI: 10.1016/J.Stemcr.2014.12.011  0.703
2014 Lian X, Bao X, Al-Ahmad A, Liu J, Wu Y, Dong W, Dunn KK, Shusta EV, Palecek SP. Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling. Stem Cell Reports. 3: 804-16. PMID 25418725 DOI: 10.1016/J.Stemcr.2014.09.005  0.712
2014 Wilson HK, Canfield SG, Shusta EV, Palecek SP. Concise review: tissue-specific microvascular endothelial cells derived from human pluripotent stem cells. Stem Cells (Dayton, Ohio). 32: 3037-45. PMID 25070152 DOI: 10.1002/Stem.1797  0.346
2014 Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV. Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae. Applied and Environmental Microbiology. 80: 5732-42. PMID 25015885 DOI: 10.1128/Aem.01466-14  0.671
2014 Tan LN, Wiepz GJ, Miller DS, Shusta EV, Abbott NL. Liquid crystal droplet-based amplification of microvesicles that are shed by mammalian cells. The Analyst. 139: 2386-96. PMID 24667742 DOI: 10.1039/C3An02360E  0.327
2014 Zhang X, Wang XX, Shusta EV. Creation and Evaluation of a Single-chain Antibody Tetramer that Targets Brain Endothelial Cells. Aiche Journal. American Institute of Chemical Engineers. 60: 1245-1252. PMID 24659822 DOI: 10.1002/Aic.14348  0.475
2014 Jones AR, Stutz CC, Zhou Y, Marks JD, Shusta EV. Identifying blood-brain-barrier selective single-chain antibody fragments. Biotechnology Journal. 9: 664-74. PMID 24644233 DOI: 10.1002/Biot.201300550  0.487
2014 Lippmann ES, Al-Ahmad A, Azarin SM, Palecek SP, Shusta EV. A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Scientific Reports. 4: 4160. PMID 24561821 DOI: 10.1038/Srep04160  0.805
2014 Malin D, Strekalova E, Petrovic V, Deal AM, Al Ahmad A, Adamo B, Miller CR, Ugolkov A, Livasy C, Fritchie K, Hamilton E, Blackwell K, Geradts J, Ewend M, Carey L, ... Shusta EV, et al. αB-crystallin: a novel regulator of breast cancer metastasis to the brain. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 56-67. PMID 24132917 DOI: 10.1158/1078-0432.Ccr-13-1255  0.349
2014 Stutz CC, Zhang X, Shusta EV. Combinatorial approaches for the identification of brain drug delivery targets. Current Pharmaceutical Design. 20: 1564-76. PMID 23789958 DOI: 10.2174/13816128113199990459  0.439
2013 Marshall CJ, Agarwal N, Kalia J, Grosskopf VA, McGrath NA, Abbott NL, Raines RT, Shusta EV. Facile chemical functionalization of proteins through intein-linked yeast display. Bioconjugate Chemistry. 24: 1634-44. PMID 23924245 DOI: 10.1021/Bc4002618  0.363
2013 Lippmann ES, Al-Ahmad A, Palecek SP, Shusta EV. Modeling the blood-brain barrier using stem cell sources. Fluids and Barriers of the Cns. 10: 2. PMID 23305164 DOI: 10.1186/2045-8118-10-2  0.81
2013 Tillotson BJ, de Larrinoa IF, Skinner CA, Klavas DM, Shusta EV. Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources. Protein Engineering, Design & Selection : Peds. 26: 101-12. PMID 23109730 DOI: 10.1093/Protein/Gzs077  0.806
2013 Tillotson BJ, Cho YK, Shusta EV. Cells and cell lysates: a direct approach for engineering antibodies against membrane proteins using yeast surface display. Methods (San Diego, Calif.). 60: 27-37. PMID 22449570 DOI: 10.1016/J.Ymeth.2012.03.010  0.794
2012 Pavoor TV, Wheasler JA, Kamat V, Shusta EV. An enhanced approach for engineering thermally stable proteins using yeast display. Protein Engineering, Design & Selection : Peds. 25: 625-30. PMID 22767886 DOI: 10.1093/Protein/Gzs041  0.756
2012 Lippmann ES, Azarin SM, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, Palecek SP, Shusta EV. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nature Biotechnology. 30: 783-91. PMID 22729031 DOI: 10.1038/Nbt.2247  0.808
2011 Lippmann ES, Weidenfeller C, Svendsen CN, Shusta EV. Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons. Journal of Neurochemistry. 119: 507-20. PMID 21854389 DOI: 10.1111/J.1471-4159.2011.07434.X  0.683
2011 Shayan G, Choi YS, Shusta EV, Shuler ML, Lee KH. Murine in vitro model of the blood-brain barrier for evaluating drug transport. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 42: 148-55. PMID 21078386 DOI: 10.1016/J.Ejps.2010.11.005  0.427
2010 Cho YK, Shusta EV. Antibody library screens using detergent-solubilized mammalian cell lysates as antigen sources. Protein Engineering, Design & Selection : Peds. 23: 567-77. PMID 20498037 DOI: 10.1093/Protein/Gzq029  0.432
2010 Agarwal N, Lippmann ES, Shusta EV. Identification and expression profiling of blood-brain barrier membrane proteins. Journal of Neurochemistry. 112: 625-35. PMID 19895664 DOI: 10.1111/J.1471-4159.2009.06481.X  0.691
2009 Pavoor TV, Cho YK, Shusta EV. Development of GFP-based biosensors possessing the binding properties of antibodies. Proceedings of the National Academy of Sciences of the United States of America. 106: 11895-900. PMID 19574456 DOI: 10.1073/Pnas.0902828106  0.762
2009 Agarwal N, Shusta EV. Multiplex expression cloning of blood-brain barrier membrane proteins. Proteomics. 9: 1099-108. PMID 19180536 DOI: 10.1002/Pmic.200800368  0.434
2009 Cho YK, Chen I, Wei X, Li L, Shusta EV. A yeast display immunoprecipitation method for efficient isolation and characterization of antigens. Journal of Immunological Methods. 341: 117-26. PMID 19041873 DOI: 10.1016/J.Jim.2008.11.005  0.408
2009 Jones AR, Shusta EV. Antibodies and the Blood-Brain Barrier Therapeutic Monoclonal Antibodies: From Bench to Clinic. 483-502. DOI: 10.1002/9780470485408.ch21  0.324
2008 Huang D, Gore PR, Shusta EV. Increasing yeast secretion of heterologous proteins by regulating expression rates and post-secretory loss. Biotechnology and Bioengineering. 101: 1264-75. PMID 18781684 DOI: 10.1002/Bit.22019  0.507
2008 Wentz AE, Shusta EV. Enhanced secretion of heterologous proteins from yeast by overexpression of ribosomal subunit RPP0. Biotechnology Progress. 24: 748-56. PMID 18396911 DOI: 10.1021/Bp070345M  0.789
2008 Pepper LR, Cho YK, Boder ET, Shusta EV. A decade of yeast surface display technology: where are we now? Combinatorial Chemistry & High Throughput Screening. 11: 127-34. PMID 18336206 DOI: 10.2174/138620708783744516  0.332
2008 Calabria AR, Shusta EV. A genomic comparison of in vivo and in vitro brain microvascular endothelial cells. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 135-48. PMID 17565361 DOI: 10.1038/Sj.Jcbfm.9600518  0.778
2007 Jones AR, Shusta EV. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharmaceutical Research. 24: 1759-71. PMID 17619996 DOI: 10.1007/S11095-007-9379-0  0.393
2007 Weidenfeller C, Svendsen CN, Shusta EV. Differentiating embryonic neural progenitor cells induce blood-brain barrier properties. Journal of Neurochemistry. 101: 555-65. PMID 17254017 DOI: 10.1111/J.1471-4159.2006.04394.X  0.45
2007 Wang XX, Cho YK, Shusta EV. Mining a yeast library for brain endothelial cell-binding antibodies. Nature Methods. 4: 143-5. PMID 17206151 DOI: 10.1038/Nmeth993  0.452
2007 Wentz AE, Shusta EV. A novel high-throughput screen reveals yeast genes that increase secretion of heterologous proteins. Applied and Environmental Microbiology. 73: 1189-98. PMID 17189442 DOI: 10.1128/Aem.02427-06  0.792
2006 Huang D, Shusta EV. A yeast platform for the production of single-chain antibody-green fluorescent protein fusions. Applied and Environmental Microbiology. 72: 7748-59. PMID 17028228 DOI: 10.1128/Aem.01403-06  0.552
2006 Calabria AR, Shusta EV. Blood-brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery. Drug Discovery Today. 11: 792-9. PMID 16935746 DOI: 10.1016/J.Drudis.2006.07.006  0.767
2006 Calabria AR, Weidenfeller C, Jones AR, de Vries HE, Shusta EV. Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction. Journal of Neurochemistry. 97: 922-33. PMID 16573646 DOI: 10.1111/J.1471-4159.2006.03793.X  0.766
2006 Hackel BJ, Huang D, Bubolz JC, Wang XX, Shusta EV. Production of soluble and active transferrin receptor-targeting single-chain antibody using Saccharomyces cerevisiae. Pharmaceutical Research. 23: 790-7. PMID 16550469 DOI: 10.1007/S11095-006-9778-7  0.699
2005 Wang XX, Shusta EV. The use of scFv-displaying yeast in mammalian cell surface selections. Journal of Immunological Methods. 304: 30-42. PMID 16099466 DOI: 10.1016/J.Jim.2005.05.006  0.352
2005 Huang D, Shusta EV. Secretion and surface display of green fluorescent protein using the yeast Saccharomyces cerevisiae. Biotechnology Progress. 21: 349-57. PMID 15801770 DOI: 10.1021/Bp0497482  0.545
2005 Shusta EV. Blood-brain barrier genomics, proteomics, and new transporter discovery. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 151-61. PMID 15717066 DOI: 10.1602/Neurorx.2.1.151  0.417
2003 Shusta EV, Li JY, Boado RJ, Pardridge WM. The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature. Neuroreport. 14: 1861-5. PMID 14534436 DOI: 10.1097/00001756-200310060-00021  0.658
2002 Shusta EV, Zhu C, Boado RJ, Pardridge WM. Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier. Journal of Neuropathology and Experimental Neurology. 61: 597-604. PMID 12125738 DOI: 10.1093/Jnen/61.7.597  0.627
2002 Shusta EV, Boado RJ, Pardridge WM. Vascular proteomics and subtractive antibody expression cloning. Molecular & Cellular Proteomics : McP. 1: 75-82. PMID 12096143 DOI: 10.1074/Mcp.T100008-Mcp200  0.641
2002 Shusta EV, Boado RJ, Mathern GW, Pardridge WM. Vascular genomics of the human brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 245-52. PMID 11891429 DOI: 10.1097/00004647-200203000-00001  0.635
2001 Kieke MC, Sundberg E, Shusta EV, Mariuzza RA, Wittrup KD, Kranz DM. High affinity T cell receptors from yeast display libraries block T cell activation by superantigens. Journal of Molecular Biology. 307: 1305-15. PMID 11292343 DOI: 10.1006/Jmbi.2001.4560  0.583
2000 Shusta EV, Holler PD, Kieke MC, Kranz DM, Wittrup KD. Directed evolution of a stable scaffold for T-cell receptor engineering. Nature Biotechnology. 18: 754-9. PMID 10888844 DOI: 10.1038/77325  0.604
2000 Holler PD, Holman PO, Shusta EV, O'Herrin S, Wittrup KD, Kranz DM. In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Proceedings of the National Academy of Sciences of the United States of America. 97: 5387-92. PMID 10779548 DOI: 10.1073/Pnas.080078297  0.555
1999 Shusta EV, Kieke MC, Parke E, Kranz DM, Wittrup KD. Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency. Journal of Molecular Biology. 292: 949-56. PMID 10512694 DOI: 10.1006/Jmbi.1999.3130  0.561
1999 Kieke MC, Shusta EV, Boder ET, Teyton L, Wittrup KD, Kranz DM. Selection of functional T cell receptor mutants from a yeast surface-display library. Proceedings of the National Academy of Sciences of the United States of America. 96: 5651-6. PMID 10318939 DOI: 10.1073/Pnas.96.10.5651  0.588
1999 Shusta EV, Vanantwerp J, Wittrup KD. Biosynthetic polypeptide libraries Current Opinion in Biotechnology. 10: 117-122. PMID 10209135 DOI: 10.1016/S0958-1669(99)80020-2  0.439
1998 Shusta EV, Raines RT, Plückthun A, Wittrup KD. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments Nature Biotechnology. 16: 773-777. PMID 9702778 DOI: 10.1038/nbt0898-773  0.527
Low-probability matches (unlikely to be authored by this person)
2018 Waters EA, Shusta EV. The variable lymphocyte receptor as an antibody alternative. Current Opinion in Biotechnology. 52: 74-79. PMID 29597074 DOI: 10.1016/j.copbio.2018.02.016  0.297
2007 Weidenfeller C, Shusta EV. Blood–brain barrier Endothelial Biomedicine. 1124-1139. DOI: 10.1017/CBO9780511546198.124  0.296
2021 Gastfriend BD, Nishihara H, Canfield SG, Foreman KL, Engelhardt B, Palecek SP, Shusta EV. Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells. Elife. 10. PMID 34755601 DOI: 10.7554/eLife.70992  0.293
2025 Foreman KL, Gastfriend BD, Katt ME, Palecek SP, Shusta EV. Transcriptional Responses of In Vitro Blood-Brain Barrier Models to Shear Stress. Biomolecules. 15. PMID 40001496 DOI: 10.3390/biom15020193  0.29
2025 Ding Y, Tamhankar S, Du F, Christopherson T, Schlueter N, Cohen JR, Shusta EV, Palecek SP. ETV2 Overexpression Promotes Efficient Differentiation of Pluripotent Stem Cells to Endothelial Cells. Biotechnology and Bioengineering. PMID 40134129 DOI: 10.1002/bit.28979  0.279
2020 Luo H, Shusta EV. Blood-Brain Barrier Modulation to Improve Glioma Drug Delivery. Pharmaceutics. 12. PMID 33198244 DOI: 10.3390/pharmaceutics12111085  0.273
2023 Lopez-Morales J, Vanella R, Appelt EA, Whillock S, Paulk AM, Shusta EV, Hackel BJ, Liu CC, Nash MA. Protein Engineering and High-Throughput Screening by Yeast Surface Display: Survey of Current Methods. Small Science. 3. PMID 39071103 DOI: 10.1002/smsc.202300095  0.268
2020 Pulido RS, Munji RN, Chan TC, Quirk CR, Weiner GA, Weger BD, Rossi MJ, Elmsaouri S, Malfavon M, Deng A, Profaci CP, Blanchette M, Qian T, Foreman KL, Shusta EV, et al. Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes. Neuron. PMID 32979312 DOI: 10.1016/j.neuron.2020.09.002  0.264
2022 Umlauf BJ, Kuo JS, Shusta EV. Identification of Brain ECM Binding Variable Lymphocyte Receptors Using Yeast Surface Display. Methods in Molecular Biology (Clifton, N.J.). 2491: 235-248. PMID 35482194 DOI: 10.1007/978-1-0716-2285-8_13  0.257
2022 Nishihara H, Perriot S, Gastfriend BD, Steinfort M, Cibien C, Soldati S, Matsuo K, Guimbal S, Mathias A, Palecek SP, Shusta EV, Du Pasquier R, Engelhardt B. Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis. Brain : a Journal of Neurology. PMID 35085379 DOI: 10.1093/brain/awac019  0.247
2017 Traxlmayr MW, Shusta EV. Directed Evolution of Protein Thermal Stability Using Yeast Surface Display. Methods in Molecular Biology (Clifton, N.J.). 1575: 45-65. PMID 28255874 DOI: 10.1007/978-1-4939-6857-2_4  0.237
2018 Umlauf B, Mix KA, Grosskopf VA, Raines RT, Shusta EV. Site-Specific Antibody Functionalization Using Tetrazine-Styrene Cycloaddition. Bioconjugate Chemistry. PMID 29694034 DOI: 10.1021/Acs.Bioconjchem.8B00114  0.235
2020 Sun MR, Chung HM, Matsuk V, Fink DM, Stebbins MJ, Palecek SP, Shusta EV, Lipinski RJ. Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development. Frontiers in Cell and Developmental Biology. 8: 590539. PMID 33117819 DOI: 10.3389/fcell.2020.590539  0.231
2024 Boutom SM, Silva TP, Palecek SP, Shusta EV, Fernandes TG, Ashton RS. Central nervous system vascularization in human embryos and neural organoids. Cell Reports. 43: 115068. PMID 39693224 DOI: 10.1016/j.celrep.2024.115068  0.23
2024 Appelt EA, Thoden JB, Gehrke SA, Bachmeier HD, Rayment I, Shusta EV, Holden HM. The High-Resolution Structure of a Variable Lymphocyte Receptor From Petromyzon marinus Capable of Binding to the Brain Extracellular Matrix. Proteins. PMID 39601379 DOI: 10.1002/prot.26768  0.219
2019 Canfield SG, Stebbins MJ, Faubion MG, Gastfriend BD, Palecek SP, Shusta EV. Correction to: An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons. Fluids and Barriers of the Cns. 16: 31. PMID 31506073 DOI: 10.1186/s12987-019-0151-8  0.216
2025 Tamhankar S, Shusta EV, Palecek SP. Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy. Cell Stem Cell. 32: 1-3. PMID 39753109 DOI: 10.1016/j.stem.2024.12.001  0.208
2021 Wang L, Sievert D, Clark AE, Lee S, Federman H, Gastfriend BD, Shusta EV, Palecek SP, Carlin AF, Gleeson JG. A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology. Nature Medicine. PMID 34244682 DOI: 10.1038/s41591-021-01443-1  0.157
2021 Wang L, Sievert D, Clark AE, Lee S, Federman H, Gastfriend BD, Shusta EV, Palecek SP, Carlin AF, Gleeson JG. A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology. Nature Medicine. PMID 34244682 DOI: 10.1038/s41591-021-01443-1  0.157
2025 Appelt EA, Thoden JB, Dancy C, Bachmeier HD, Gehrke SA, Staffenson MA, Rayment I, Katt ME, Holden HM, Shusta EV. A method for facile production of variable lymphocyte receptors using SHuffle Escherichia coli. Biotechnology Progress. e3530. PMID 39846486 DOI: 10.1002/btpr.3530  0.157
2021 Wang L, Sievert D, Clark AE, Federman H, Gastfriend BD, Shusta E, Palecek SP, Carlin AF, Gleeson J. A Human 3D neural assembloid model for SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology. PMID 33594369 DOI: 10.1101/2021.02.09.430349  0.139
2021 Gleeson J, Wang L, Sievert D, Clark A, Federman H, Gastfriend B, Shusta EV, Palecek SP, Carlin A. A Human 3D neural assembloid model for SARS-CoV-2 infection. Research Square. PMID 33594354 DOI: 10.21203/rs.3.rs-214352/v1  0.139
2024 Ding Y, Palecek SP, Shusta EV. iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta. Fluids and Barriers of the Cns. 21: 79. PMID 39394110 DOI: 10.1186/s12987-024-00580-2  0.136
2021 Lee MS, Stebbins MJ, Jiao H, Huang HC, Leiferman EM, Walczak BE, Palecek SP, Shusta EV, Li WJ. Comparative evaluation of isogenic mesodermal and ectomesodermal chondrocytes from human iPSCs for cartilage regeneration. Science Advances. 7. PMID 34138734 DOI: 10.1126/sciadv.abf0907  0.131
2018 Pate KM, Kim BJ, Shusta EV, Murphy RM. Transthyretin Mimetics as Anti-β-Amyloid Agents: A comparison of peptide and protein approaches. Chemmedchem. PMID 29512286 DOI: 10.1002/Cmdc.201800031  0.13
2023 Yan Q, Jacobson TB, Ye Z, Cortés-Pena YR, Bhagwat SS, Hubbard S, Cordell WT, Oleniczak RE, Gambacorta FV, Vazquez JR, Shusta EV, Amador-Noguez D, Guest JS, Pfleger BF. Evaluation of 1,2-diacyl-3-acetyl triacylglycerol production in Yarrowia lipolytica. Metabolic Engineering. 76: 18-28. PMID 36626963 DOI: 10.1016/j.ymben.2023.01.003  0.075
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