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Kou-San Ju, Ph.D. - Publications

Affiliations: 
2002 Center for Environmental Biotechnology Lawrence Berkeley National Lab, UC Berkeley 
 2009 Microbiology University of California, Davis, Davis, CA 
 2016 Institute for Genomic Biology University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 2016- Microbiology Ohio State University, Columbus, Columbus, OH 
 2016- Medicinal Chemistry and Pharmacognosy Ohio State University, Columbus, Columbus, OH 
 2017- Biological Chemistry and Pharmacology Ohio State University, Columbus, Columbus, OH 
Area:
Microbiology, Biochemistry, Natural Products
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Cui J, Ju KS. Biosynthesis of Phosphonoalamides Reveals Highly Specific Amino Acid Ligation. Acs Chemical Biology. PMID 38885091 DOI: 10.1021/acschembio.4c00190  0.727
2024 Cui J, Zhang Y, Ju KS. Phosphonoalamides Reveal the Biosynthetic Origin of Phosphonoalanine Natural Products and a Convergent Pathway for Their Diversification. Angewandte Chemie (International Ed. in English). e202405052. PMID 38780891 DOI: 10.1002/anie.202405052  0.854
2024 Zuffa S, Schmid R, Bauermeister A, P Gomes PW, Caraballo-Rodriguez AM, El Abiead Y, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, ... ... Ju KS, et al. microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data. Nature Microbiology. PMID 38316926 DOI: 10.1038/s41564-023-01575-9  0.544
2023 Dorrestein P, Zuffa S, Schmid R, Bauermeister A, Gomes PWP, Caraballo-Rodriguez A, Abiead YE, Aron A, Gentry E, Zemlin J, Meehan M, Avalon N, Cichewicz R, Buzun E, Carrillo-Terrazas M, ... ... Ju KS, et al. A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data. Research Square. PMID 37577622 DOI: 10.21203/rs.3.rs-3189768/v1  0.547
2023 Wilson J, Cui J, Nakao T, Kwok H, Zhang Y, Kayrouz CM, Pham TM, Roodhouse H, Ju KS. Discovery of Antimicrobial Phosphonopeptide Natural Products from Bacillus velezensis by Genome Mining. Applied and Environmental Microbiology. 89: e0033823. PMID 37377428 DOI: 10.1128/aem.00338-23  0.667
2023 Bown L, Hirota R, Goettge MN, Cui J, Krist DT, Zhu L, Giurgiu C, van der Donk WA, Ju KS, Metcalf WW. A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria. Journal of Bacteriology. e0048522. PMID 37074199 DOI: 10.1128/jb.00485-22  0.829
2023 Cuellar-Gaviria TZ, García-Botero C, Ju KS, Villegas-Escobar V. The genome of EA-CB0015 sheds light into its epiphytic lifestyle and potential as a biocontrol agent. Frontiers in Microbiology. 14: 1135487. PMID 37051516 DOI: 10.3389/fmicb.2023.1135487  0.397
2022 Ju KS, Nair SK. Convergent and divergent biosynthetic strategies towards phosphonic acid natural products. Current Opinion in Chemical Biology. 71: 102214. PMID 36202046 DOI: 10.1016/j.cbpa.2022.102214  0.517
2022 Zhang Y, Chen L, Wilson JA, Cui J, Roodhouse H, Kayrouz C, Pham TM, Ju KS. Valinophos Reveals a New Route in Microbial Phosphonate Biosynthesis That Is Broadly Conserved in Nature. Journal of the American Chemical Society. PMID 35617676 DOI: 10.1021/jacs.2c02854  0.733
2022 Zhang Y, Pham TM, Kayrouz C, Ju KS. Biosynthesis of Argolaphos Illuminates the Unusual Biochemical Origins of Aminomethylphosphonate and N-Hydroxyarginine Containing Natural Products. Journal of the American Chemical Society. PMID 35616638 DOI: 10.1021/jacs.2c00627  0.82
2020 Tryon JH, Rote JC, Chen L, Robey MT, Vega MM, Phua WC, Metcalf WW, Ju KS, Kelleher NL, Thomson RJ. Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster. Acs Chemical Biology. PMID 33151679 DOI: 10.1021/acschembio.0c00663  0.726
2020 Kayrouz CM, Zhang Y, Pham TM, Ju KS. Genome Mining Reveals the Phosphonoalamide Natural Products and a New Route in Phosphonic Acid Biosynthesis. Acs Chemical Biology. PMID 32484327 DOI: 10.1021/Acschembio.0C00256  0.813
2019 Parkinson EI, Erb A, Eliot AC, Ju KS, Metcalf WW. Fosmidomycin biosynthesis diverges from related phosphonate natural products. Nature Chemical Biology. PMID 31451762 DOI: 10.1038/S41589-019-0343-1  0.745
2019 Ali T, Pham TM, Ju KS, Rakotondraibe HL. -homocyclopiamine B, a Prenylated Indole Alkaloid of Biogenetic Interest from the Endophytic Fungus . Molecules (Basel, Switzerland). 24. PMID 30634398 DOI: 10.3390/Molecules24020218  0.659
2018 Goettge MN, Cioni JP, Ju KS, Pallitsch K, Metcalf WW. -PcxL and HpxL are flavin-dependent, oxime-forming N-oxidases in phosphonocystoximic acid biosynthesis in. The Journal of Biological Chemistry. PMID 29540479 DOI: 10.1074/Jbc.Ra118.001721  0.628
2018 Parkinson EI, Tryon JH, Goering AW, Ju KS, McClure RA, Kemball JD, Zhukovsky S, Labeda DP, Thomson RJ, Kelleher NL, Metcalf WW. Discovery of the tyrobetaine natural products and their biosynthetic gene cluster via metabologenomics. Acs Chemical Biology. PMID 29510029 DOI: 10.1021/Acschembio.7B01089  0.623
2017 Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL. Structural basis for methylphosphonate biosynthesis. Science (New York, N.Y.). 358: 1336-1339. PMID 29217579 DOI: 10.1126/Science.Aao3435  0.302
2017 Ju KS, Zhang X, Elliot MA. New kid on the block: LmbU expands the repertoire of specialized metabolic regulators in Streptomyces. Journal of Bacteriology. PMID 29084856 DOI: 10.1128/Jb.00559-17  0.557
2017 Freestone TS, Ju KS, Wang B, Zhao H. Discovery of a phosphonoacetic acid derived natural product by pathway refactoring. Acs Synthetic Biology. PMID 28103011 DOI: 10.1021/Acssynbio.6B00299  0.434
2016 Labeda DP, Dunlap CA, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW. Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis. Antonie Van Leeuwenhoek. PMID 28039547 DOI: 10.1007/S10482-016-0824-0  0.633
2016 McClure RA, Goering AW, Ju KS, Baccile JA, Schroeder FC, Metcalf WW, Thomson RJ, Kelleher NL. Elucidating the rimosamide-detoxin natural product families and their biosynthesis using metabolite/gene cluster correlations. Acs Chemical Biology. PMID 27809474 DOI: 10.1021/Acschembio.6B00779  0.702
2016 Goering AW, McClure RA, Doroghazi JR, Albright JC, Haverland NA, Zhang Y, Ju KS, Thomson RJ, Metcalf WW, Kelleher NL. Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. Acs Central Science. 2: 99-108. PMID 27163034 DOI: 10.1021/Acscentsci.5B00331  0.733
2016 Labeda DP, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW. Taxonomic evaluation of species in the Streptomyces hirsutus clade using multi-locus sequence analysis and proposals to reclassify several species in this clade. International Journal of Systematic and Evolutionary Microbiology. PMID 26971011 DOI: 10.1099/Ijsem.0.001017  0.564
2015 Ju KS, Gao J, Doroghazi JR, Wang KA, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, et al. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26324907 DOI: 10.1073/Pnas.1500873112  0.764
2015 Mahan KM, Penrod JT, Ju KS, Al Kass N, Tan WA, Truong R, Parales JV, Parales RE. Selection for growth on 3-nitrotoluene by 2-nitrotoluene-utilizing Acidovorax sp. strain JS42 identifies nitroarene dioxygenases with altered specificities. Applied and Environmental Microbiology. 81: 309-19. PMID 25344236 DOI: 10.1128/Aem.02772-14  0.736
2014 Doroghazi JR, Albright JC, Goering AW, Ju KS, Haines RR, Tchalukov KA, Labeda DP, Kelleher NL, Metcalf WW. A roadmap for natural product discovery based on large-scale genomics and metabolomics. Nature Chemical Biology. 10: 963-8. PMID 25262415 DOI: 10.1038/Nchembio.1659  0.709
2014 Cioni JP, Doroghazi JR, Ju KS, Yu X, Evans BS, Lee J, Metcalf WW. Cyanohydrin phosphonate natural product from Streptomyces regensis. Journal of Natural Products. 77: 243-9. PMID 24437999 DOI: 10.1021/Np400722M  0.726
2014 Gao J, Ju KS, Yu X, Velásquez JE, Mukherjee S, Lee J, Zhao C, Evans BS, Doroghazi JR, Metcalf WW, van der Donk WA. Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angewandte Chemie (International Ed. in English). 53: 1334-7. PMID 24376039 DOI: 10.1002/Anie.201308363  0.696
2014 Ju KS, Doroghazi JR, Metcalf WW. Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways. Journal of Industrial Microbiology & Biotechnology. 41: 345-56. PMID 24271089 DOI: 10.1007/S10295-013-1375-2  0.734
2013 Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. Acs Chemical Biology. 8: 908-13. PMID 23474169 DOI: 10.1021/Cb400102T  0.701
2012 Kim SY, Ju KS, Metcalf WW, Evans BS, Kuzuyama T, Van Der Donk WA. Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species Antimicrobial Agents and Chemotherapy. 56: 4175-4183. PMID 22615277 DOI: 10.1128/Aac.06478-11  0.717
2012 Chen Y, Ntai I, Ju KS, Unger M, Zamdborg L, Robinson SJ, Doroghazi JR, Labeda DP, Metcalf WW, Kelleher NL. A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria. Journal of Proteome Research. 11: 85-94. PMID 21978092 DOI: 10.1021/Pr2009115  0.689
2011 Doroghazi JR, Ju KS, Brown DW, Labeda DP, Deng Z, Metcalf WW, Chen W, Price NP. Genome sequences of three tunicamycin-producing Streptomyces Strains, S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396. Journal of Bacteriology. 193: 7021-2. PMID 22123769 DOI: 10.1128/Jb.06262-11  0.67
2011 Ju KS, Parales RE. Evolution of a new bacterial pathway for 4-nitrotoluene degradation. Molecular Microbiology. 82: 355-64. PMID 21895789 DOI: 10.1111/J.1365-2958.2011.07817.X  0.717
2010 Ju KS, Parales RE. Nitroaromatic compounds, from synthesis to biodegradation. Microbiology and Molecular Biology Reviews : Mmbr. 74: 250-72. PMID 20508249 DOI: 10.1128/Mmbr.00006-10  0.691
2009 Ju KS, Parales RE. Application of nitroarene dioxygenases in the design of novel strains that degrade chloronitrobenzenes. Microbial Biotechnology. 2: 241-52. PMID 21261918 DOI: 10.1111/J.1751-7915.2008.00083.X  0.687
2009 Ju KS, Parales JV, Parales RE. Reconstructing the evolutionary history of nitrotoluene detection in the transcriptional regulator NtdR. Molecular Microbiology. 74: 826-43. PMID 19849778 DOI: 10.1111/J.1365-2958.2009.06904.X  0.707
2006 Ju KS, Parales RE. Control of substrate specificity by active-site residues in nitrobenzene dioxygenase. Applied and Environmental Microbiology. 72: 1817-24. PMID 16517627 DOI: 10.1128/Aem.72.3.1817-1824.2006  0.646
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