Laurence A. Turka - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology, Immunology

273 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ho P, Cahir-McFarland E, Fontenot JD, Lodie T, Nada A, Tang Q, Turka LA, Bluestone JA. Harnessing regulatory T cells to establish immune tolerance. Science Translational Medicine. 16: eadm8859. PMID 38478632 DOI: 10.1126/scitranslmed.adm8859  0.404
2021 Shimozawa K, Contreras-Ruiz L, Sousa S, Zhang R, Bhatia U, Crisalli KC, Brennan LL, Turka LA, Markmann JF, Guinan EC. Ex vivo generation of regulatory T cells from liver transplant recipients using costimulation blockade. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 34528383 DOI: 10.1111/ajt.16842  0.343
2021 McArdel SL, Dugast AS, Hoover ME, Bollampalli A, Hong E, Castano Z, Leonard SC, Pawar S, Mellen J, Muriuki K, McLaughlin DC, Bayhi N, Carpenter CL, Turka LA, Wickham TJ, et al. Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15. Cancer Immunology, Immunotherapy : Cii. PMID 34244816 DOI: 10.1007/s00262-021-03001-7  0.433
2021 Zhang X, Luo M, Dastagir SR, Nixon M, Khamhoung A, Schmidt A, Lee A, Subbiah N, McLaughlin DC, Moore CL, Gribble M, Bayhi N, Amin V, Pepi R, Pawar S, ... ... Turka LA, et al. Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic. Nature Communications. 12: 2637. PMID 33976146 DOI: 10.1038/s41467-021-22898-3  0.32
2020 Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, ... ... Turka LA, et al. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet (London, England). 395: 1627-1639. PMID 32446407 DOI: 10.1016/S0140-6736(20)30167-7  0.332
2020 Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, ... ... Turka LA, et al. Beta cell-specific CD8 T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes. Nature Immunology. PMID 32231298 DOI: 10.1038/S41590-020-0633-5  0.536
2019 Harris KM, Lim N, Lindau P, Robins H, Griffith LM, Nash RA, Turka LA, Muraro PA. Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis. Jci Insight. PMID 31877116 DOI: 10.1172/Jci.Insight.127655  0.519
2019 Levitsky J, Burrell BE, Kanaparthi S, Turka LA, Kurian S, Sanchez-Fueyo A, Lozano JJ, Demetris A, Lesniak A, Kirk AD, Stempora L, Yang GY, Mathew JM. Immunosuppression withdrawal in liver transplant recipients on sirolimus. Hepatology (Baltimore, Md.). PMID 31721246 DOI: 10.1002/Hep.31036  0.472
2019 Tanimine N, Germana SK, Fan M, Hippen K, Blazar BR, Markmann JF, Turka LA, Priyadharshini B. Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets. Plos One. 14: e0217761. PMID 31170216 DOI: 10.1371/Journal.Pone.0217761  0.54
2019 Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, ... ... Turka LA, et al. Targeting PI3Kδ Function For Amelioration of Murine Chronic Graft-Versus-Host Disease. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 30748099 DOI: 10.1111/Ajt.15305  0.492
2019 Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, et al. Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. Journal of Immunology (Baltimore, Md. : 1950). PMID 30683697 DOI: 10.4049/Jimmunol.1801425  0.593
2019 Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature. PMID 30626970 DOI: 10.1038/S41586-018-0846-Z  0.539
2018 Savage TM, Shonts BA, Obradovic A, Dewolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho SH, Tang Q, Turka LA, Shen Y, Sykes M. Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. Jci Insight. 3. PMID 30429370 DOI: 10.1172/Jci.Insight.124086  0.414
2018 Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Reports. 25: 1204-1213.e4. PMID 30380412 DOI: 10.1016/J.Celrep.2018.10.002  0.407
2018 Priyadharshini B, Loschi M, Newton RH, Zhang JW, Finn KK, Gerriets VA, Huynh A, Rathmell JC, Blazar BR, Turka LA. Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets. Journal of Immunology (Baltimore, Md. : 1950). PMID 30209190 DOI: 10.4049/Jimmunol.1800311  0.394
2018 McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, ... ... Turka LA, et al. The vimentin intermediate filament network restrains regulatory T-cell suppression of graft-versus-host disease. The Journal of Clinical Investigation. PMID 30106752 DOI: 10.1172/Jci95713  0.499
2018 Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nature Immunology. PMID 29988091 DOI: 10.1038/S41590-018-0157-4  0.747
2018 Marangoni F, Zhang R, Mani V, Thelen M, Ali Akbar NJ, Warner RD, Äijö T, Zappulli V, Martinez GJ, Turka LA, Mempel TR. Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin. Journal of Immunology (Baltimore, Md. : 1950). PMID 29661826 DOI: 10.4049/Jimmunol.1701220  0.458
2018 Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29475985 DOI: 10.4049/Jimmunol.1800150  0.486
2018 Harris KM, Lu T, Lim N, Turka LA. Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity. Frontiers in Immunology. 9: 100. PMID 29456529 DOI: 10.3389/Fimmu.2018.00100  0.446
2018 Newell KA, Adams AB, Turka LA. Biomarkers of Operational Tolerance Following Kidney Transplantation - The Immune Tolerance Network Studies of Spontaneously Tolerant Kidney Transplant Recipients. Human Immunology. PMID 29448053 DOI: 10.1016/J.Humimm.2018.02.007  0.388
2018 Fan MY, Turka LA. Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells. Frontiers in Immunology. 9: 69. PMID 29434595 DOI: 10.3389/Fimmu.2018.00069  0.484
2018 Fu J, Zuber J, Shonts B, Bi K, Yates K, Ma W, Obradovic A, Yang S, Ho S, Turka L, Farber D, Haining N, Shen Y, Satwani P, Martinez M, et al. Clonal and Functional Analysis Reveals the Capacity of Allograft T cells to Join the Circulating Pool after Human Intestinal Transplantation Transplantation. 102: S420-S421. DOI: 10.1097/01.Tp.0000543198.71716.C3  0.45
2017 Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29093061 DOI: 10.4049/Jimmunol.1700409  0.574
2017 Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R. Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ. Nature Communications. 8: 951. PMID 29038423 DOI: 10.1038/S41467-017-00982-X  0.476
2017 Tanimine N, Turka LA, Priyadharshini B. Navigating T Cell Immunometabolism in Transplantation. Transplantation. PMID 28930796 DOI: 10.1097/Tp.0000000000001951  0.48
2017 Karnell FG, Lin D, Motley S, Duhen T, Lim N, Campbell DJ, Turka LA, Maecker HT, Harris KM. Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation. Clinical and Experimental Immunology. PMID 28498568 DOI: 10.1111/Cei.12985  0.572
2017 Asare A, Kanaparthi S, Lim N, Phippard D, Vincenti F, Friedewald J, Pavlakis M, Poggio E, Heeger P, Mannon R, Burrell BE, Morrison Y, Bridges N, Sanz I, Chandraker A, ... ... Turka LA, et al. B Cell Receptor Genes Associated with Tolerance Identify a Cohort of Immunosuppressed Patients with Improved Renal Allograft Graft Function. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 28371372 DOI: 10.1111/Ajt.14283  0.327
2017 Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science (New York, N.Y.). PMID 28280249 DOI: 10.1126/Science.Aaf0683  0.474
2017 Kean LS, Turka LA, Blazar BR. Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunological Reviews. 276: 192-212. PMID 28258702 DOI: 10.1111/Imr.12523  0.519
2017 Sprangers B, DeWolf S, Savage TM, Morokata T, Obradovic A, LoCascio SA, Shonts B, Zuber J, Lau SP, Shah R, Morris H, Steshenko V, Zorn E, Preffer FI, Olek S, ... ... Turka LA, et al. Origin of enriched regulatory t cells in patients receiving combined kidney/bone marrow transplantation to induce transplantation tolerance. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 28251801 DOI: 10.1111/Ajt.14251  0.568
2016 Alessandrini A, Turka LA. FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. PMID 28049555 DOI: 10.1053/J.Ajkd.2016.10.027  0.564
2016 Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nature Immunology. PMID 27695003 DOI: 10.1038/Ni.3577  0.444
2016 Lu Y, Hippen KL, Lemire AL, Gu J, Wang W, Ni X, Ranganathan P, Levine BL, Riley JL, June CH, Turka LA, Munn DH, Garzon R, Lu L, Blazar BR. miR-146b antagomir treated human Tregs increase TRAF6-NFkB expression, suppressor function and GVHD inhibitory potency. Blood. PMID 27485827 DOI: 10.1182/Blood-2016-05-714535  0.351
2016 McDonald-Hyman C, Flynn R, Panoskaltsis-Mortari A, Peterson N, MacDonald KP, Hill GR, Luznik L, Serody JS, Murphy WJ, Maillard I, Munn DH, Turka LA, Koreth J, Cutler CS, Soiffer RJ, et al. Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5 dependent manner. Blood. PMID 27385791 DOI: 10.1182/Blood-2016-05-715896  0.477
2016 Feng S, Demetris AJ, Spain KM, Kanaparthi S, Burrell BE, Ekong UD, Alonso EM, Rosenthal P, Turka LA, Ikle D, Tchao NK. Five year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R. Hepatology (Baltimore, Md.). PMID 27302659 DOI: 10.1002/Hep.28681  0.333
2016 Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, ... ... Turka LA, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. The Journal of Clinical Investigation. PMID 27294527 DOI: 10.1172/Jci85796  0.404
2016 Newton R, Priyadharshini B, Turka LA. Immunometabolism of regulatory T cells. Nature Immunology. 17: 618-25. PMID 27196520 DOI: 10.1038/Ni.3466  0.412
2016 Borges CM, Reichenbach DK, Kim BS, Misra A, Blazar BR, Turka LA. T Regulatory Cell Expressed Myd88 Is Critical For Prolongation Of Allograft Survival. Transplant International : Official Journal of the European Society For Organ Transplantation. PMID 27112509 DOI: 10.1111/Tri.12788  0.549
2016 Zwang NA, Zhang R, Germana S, Fan MY, Hastings WD, Cao A, Turka LA. Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the PI3-Kinase and MEK Pathways. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 27017850 DOI: 10.1111/Ajt.13805  0.468
2016 Rosenberg AS, Pariser AR, Diamond B, Yao L, Turka LA, Lacana E, Kishnani PS. A role for plasma cell targeting agents in immune tolerance induction in autoimmune disease and antibody responses to therapeutic proteins. Clinical Immunology (Orlando, Fla.). 165: 55-9. PMID 26928739 DOI: 10.1016/J.Clim.2016.02.009  0.313
2016 Guinan EC, Cole GA, Wylie WH, Kelner R, Janec KJ, Yuan H, Oppatt J, Brennan LL, Turka LA, Markmann J. Ex vivo costimulatory blockade to generate regulatory T cells from individuals awaiting kidney transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 26790369 DOI: 10.1111/Ajt.13725  0.502
2016 Kamphorst AO, Wieland A, Yang S, Nasti T, Zhang R, Barber DL, Konieczny BT, Koenig L, Yu K, Sica G, Owonikoko TK, Pillai R, Ramalingam SS, Sharpe AH, Freeman GJ, ... Turka LA, et al. Abstract 4359: Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent Cancer Research. 76: 4359-4359. DOI: 10.1158/1538-7445.Am2016-4359  0.539
2015 Newell KA, Asare A, Sanz I, Wei C, Rosenberg A, Gao Z, Kanaparthi S, Asare S, Lim N, Stahly M, Howell M, Knechtle S, Kirk A, Marks WH, Kawai T, ... ... Turka LA, et al. Longitudinal Studies of a B Cell-Derived Signature of Tolerance in Renal Transplant Recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 26461968 DOI: 10.1111/Ajt.13480  0.361
2015 Zhang R, Borges CM, Fan MY, Harris JE, Turka LA. Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin Homing. Journal of Immunology (Baltimore, Md. : 1950). PMID 26408668 DOI: 10.4049/Jimmunol.1500945  0.66
2015 Kim JI, Turka LA. Transplant tolerance: a new role for IL-34. The Journal of Clinical Investigation. 1-3. PMID 26389671 DOI: 10.1172/Jci84010  0.386
2015 McDonald-Hyman C, Turka LA, Blazar BR. Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Science Translational Medicine. 7: 280rv2. PMID 25810312 DOI: 10.1126/Scitranslmed.Aaa6853  0.335
2015 DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 42: 227-38. PMID 25680271 DOI: 10.1016/J.Immuni.2015.01.007  0.526
2015 Priyadharshini B, Turka LA. T-cell energy metabolism as a controller of cell fate in transplantation. Current Opinion in Organ Transplantation. 20: 21-8. PMID 25563988 DOI: 10.1097/Mot.0000000000000149  0.417
2015 Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nature Immunology. 16: 188-96. PMID 25559257 DOI: 10.1038/Ni.3077  0.56
2015 Newton RH, Lu Y, Papa A, Whitcher GH, Kang YJ, Yan C, Pandolfi PP, Turka LA. Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity. Blood. 125: 852-5. PMID 25477498 DOI: 10.1182/Blood-2014-04-571372  0.522
2015 Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of Clinical Investigation. 125: 194-207. PMID 25437876 DOI: 10.1172/Jci76012  0.563
2015 Shamji MH, Bellido V, Scadding GW, Layhadi JA, Cheung DK, Calderon MA, Asare A, Gao Z, Turka LA, Tchao N, Togias A, Phippard D, Durham SR. Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals. Allergy. 70: 171-9. PMID 25377909 DOI: 10.1111/All.12543  0.564
2015 Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Burrill JS, Guo L, Sacristan C, Furlan SN, ... ... Turka LA, et al. Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality Blood. 126: 147-147. DOI: 10.1182/Blood.V126.23.147.147  0.462
2014 Zwang NA, Turka LA. Homeostatic expansion as a barrier to lymphocyte depletion strategies. Current Opinion in Organ Transplantation. 19: 357-62. PMID 24926701 DOI: 10.1097/Mot.0000000000000096  0.392
2014 Stolp J, Turka LA, Wood KJ. B cells with immune-regulating function in transplantation. Nature Reviews. Nephrology. 10: 389-97. PMID 24846332 DOI: 10.1038/Nrneph.2014.80  0.415
2014 Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M, Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, ... Turka LA, et al. TIM4 regulates the anti-islet Th2 alloimmune response. Cell Transplantation. PMID 24612609 DOI: 10.3727/096368914X678571  0.36
2014 Muraro PA, Robins H, Malhotra S, Howell M, Phippard D, Desmarais C, de Paula Alves Sousa A, Griffith LM, Lim N, Nash RA, Turka LA. T cell repertoire following autologous stem cell transplantation for multiple sclerosis. The Journal of Clinical Investigation. 124: 1168-72. PMID 24531550 DOI: 10.1172/Jci71691  0.587
2014 Huynh A, Zhang R, Turka LA. Signals and pathways controlling regulatory T cells. Immunological Reviews. 258: 117-31. PMID 24517429 DOI: 10.1111/Imr.12148  0.536
2014 Feng S, Tchao N, Ekong U, Stempora L, Kirk A, Turka L, Phippard D. High Percentage of PD-1+ CD4+ T Cells in a Subset of Tolerant Pediatric Liver Recipients.: Abstract# A2 Transplantation. 98: 872. DOI: 10.1097/00007890-201407151-02975  0.444
2013 Maltzman JS, Turka LA. T-cell costimulatory blockade in organ transplantation. Cold Spring Harbor Perspectives in Medicine. 3: a015537. PMID 24296352 DOI: 10.1101/Cshperspect.A015537  0.537
2013 Zhang R, Turka LA. A breath of fresh aire. Immunity. 39: 427-9. PMID 24054325 DOI: 10.1016/J.Immuni.2013.08.022  0.421
2013 Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N. Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. Journal of Immunology (Baltimore, Md. : 1950). 191: 4447-55. PMID 24038092 DOI: 10.4049/Jimmunol.1300992  0.585
2013 Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, et al. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 38: 1211-22. PMID 23791643 DOI: 10.1016/J.Immuni.2013.05.012  0.468
2013 Huynh A, Turka LA. Control of T cell tolerance by phosphatase and tensin homolog. Annals of the New York Academy of Sciences. 1280: 27-9. PMID 23551099 DOI: 10.1111/Nyas.12015  0.59
2013 Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH. MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 2270-5. PMID 23341605 DOI: 10.1073/Pnas.1206048110  0.546
2013 Zhang R, Huynh A, Whitcher G, Chang J, Maltzman JS, Turka LA. An obligate cell-intrinsic function for CD28 in Tregs. The Journal of Clinical Investigation. 123: 580-93. PMID 23281398 DOI: 10.1172/Jci65013  0.536
2012 Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, ... ... Turka LA, et al. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 37: 511-23. PMID 22981537 DOI: 10.1016/j.immuni.2012.06.014  0.558
2012 Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes. 61: 2340-8. PMID 22721971 DOI: 10.1089/Dia.2013.1510  0.367
2012 Newton RH, Turka LA. Regulation of T cell homeostasis and responses by pten. Frontiers in Immunology. 3: 151. PMID 22715338 DOI: 10.3389/Fimmu.2012.00151  0.51
2012 Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. The Journal of Clinical Investigation. 122: 2395-404. PMID 22684103 DOI: 10.1172/Jci45138  0.562
2012 Lieberman SM, Kim JS, Corbo-Rodgers E, Kambayashi T, Maltzman JS, Behrens EM, Turka LA. Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. European Journal of Immunology. 42: 1429-35. PMID 22678899 DOI: 10.1002/Eji.201142286  0.546
2012 Tchao NK, Turka LA. Lymphodepletion and Homeostatic Proliferation: Implications for Transplantation American Journal of Transplantation. 12: 1079-1090. PMID 22420320 DOI: 10.1111/J.1600-6143.2012.04008.X  0.52
2012 Harris JE, Harris TH, Weninger W, Wherry EJ, Hunter CA, Turka LA. A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin. The Journal of Investigative Dermatology. 132: 1869-76. PMID 22297636 DOI: 10.1038/Jid.2011.463  0.755
2012 Haynes LD, Jankowska-Gan E, Sheka A, Keller MR, Hernandez-Fuentes MP, Lechler RI, Seyfert-Margolis V, Turka LA, Newell KA, Burlingham WJ. Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 12: 640-8. PMID 22151236 DOI: 10.1111/J.1600-6143.2011.03869.X  0.439
2012 Xiao X, Gong W, Demirci G, Liu W, Spoerl S, Chu X, Bishop DK, Turka LA, Li XC. New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. Journal of Immunology (Baltimore, Md. : 1950). 188: 892-901. PMID 22147766 DOI: 10.4049/Jimmunol.1101373  0.534
2012 Zhao X, Boenisch O, Yeung M, Mfarrej B, Yang S, Turka LA, Sayegh MH, Iacomini J, Yuan X. Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 12: 90-101. PMID 21992708 DOI: 10.1111/J.1600-6143.2011.03770.X  0.409
2011 Newell KA, Phippard D, Turka LA. Regulatory cells and cell signatures in clinical transplantation tolerance. Current Opinion in Immunology. 23: 655-9. PMID 21982510 DOI: 10.1016/J.Coi.2011.07.008  0.428
2011 Auchincloss H, Turka LA. CTLA-4: not all costimulation is stimulatory. Journal of Immunology (Baltimore, Md. : 1950). 187: 3457-8. PMID 21934096 DOI: 10.4049/Jimmunol.1102316  0.42
2011 Schrum AG, Gil D, Turka LA, Palmer E. Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 870-8. PMID 21666056 DOI: 10.4049/Jimmunol.1100538  0.726
2011 Wojno ED, Hosken N, Stumhofer JS, O'Hara AC, Mauldin E, Fang Q, Turka LA, Levin SD, Hunter CA. A role for IL-27 in limiting T regulatory cell populations. Journal of Immunology (Baltimore, Md. : 1950). 187: 266-73. PMID 21622862 DOI: 10.4049/Jimmunol.1004182  0.535
2011 Nepom GT, St Clair EW, Turka LA. Challenges in the pursuit of immune tolerance. Immunological Reviews. 241: 49-62. PMID 21488889 DOI: 10.1111/J.1600-065X.2011.01003.X  0.358
2011 Murphy SP, Porrett PM, Turka LA. Innate immunity in transplant tolerance and rejection. Immunological Reviews. 241: 39-48. PMID 21488888 DOI: 10.1111/J.1600-065X.2011.01009.X  0.733
2011 Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 117: 3123-30. PMID 21233312 DOI: 10.1182/Blood-2010-11-318485  0.69
2010 Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA. The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nature Reviews. Immunology. 10: 797-803. PMID 20972473 DOI: 10.1038/Nri2869  0.316
2010 Ramón HE, Cejas PJ, LaRosa D, Rahman A, Harris JE, Zhang J, Hunter C, Choi Y, Turka LA. EGR-2 is not required for in vivo CD4 T cell mediated immune responses. Plos One. 5: e12904. PMID 20886122 DOI: 10.1371/Journal.Pone.0012904  0.766
2010 D'Addio F, Yuan X, Habicht A, Williams J, Ruzek M, Iacomini J, Turka LA, Sayegh MH, Najafian N, Ansari MJ. A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation. 90: 260-9. PMID 20712076 DOI: 10.1097/Tp.0B013E3181E64217  0.527
2010 Li XC, Turka LA. An update on regulatory T cells in transplant tolerance and rejection. Nature Reviews. Nephrology. 6: 577-83. PMID 20683480 DOI: 10.1038/Nrneph.2010.101  0.542
2010 Turka LA, Wood K, Bluestone JA. Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia. Current Opinion in Organ Transplantation. 15: 441-8. PMID 20631613 DOI: 10.1097/Mot.0B013E32833Bd371  0.322
2010 Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA. Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. The Journal of Clinical Investigation. 120: 2497-507. PMID 20516645 DOI: 10.1172/Jci42382  0.8
2010 Newell KA, Asare A, Kirk AD, Gisler TD, Bourcier K, Suthanthiran M, Burlingham WJ, Marks WH, Sanz I, Lechler RI, Hernandez-Fuentes MP, Turka LA, Seyfert-Margolis VL. Identification of a B cell signature associated with renal transplant tolerance in humans. The Journal of Clinical Investigation. 120: 1836-47. PMID 20501946 DOI: 10.1172/Jci39933  0.397
2010 Cejas PJ, Walsh MC, Pearce EL, Han D, Harms GM, Artis D, Turka LA, Choi Y. TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood. 115: 4750-7. PMID 20351308 DOI: 10.1182/Blood-2009-09-242768  0.418
2009 Yang J, Riella LV, Boenisch O, Popoola J, Robles S, Watanabe T, Vanguri V, Yuan X, Guleria I, Turka LA, Sayegh MH, Chandraker A. Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 9: 2837-44. PMID 19845593 DOI: 10.1111/J.1600-6143.2009.02839.X  0.464
2009 Rahman AH, Taylor DK, Turka LA. The contribution of direct TLR signaling to T cell responses. Immunologic Research. 45: 25-36. PMID 19597998 DOI: 10.1007/S12026-009-8113-X  0.534
2009 Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, et al. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 10734-9. PMID 19528638 DOI: 10.1073/Pnas.0812538106  0.579
2009 Turka LA, Lechler RI. Towards the identification of biomarkers of transplantation tolerance. Nature Reviews. Immunology. 9: 521-6. PMID 19483711 DOI: 10.1038/Nri2568  0.321
2009 Allenspach E, Lemos M, Porrett P, Turka L, Laufer T. Migratory and Lymphoid-resident Dendritic Cells Cooperate in Murine Lymph Nodes for Efficient CD4 + T Cell Priming Journal of Allergy and Clinical Immunology. 123: S221-S221. DOI: 10.1016/J.Jaci.2008.12.848  0.749
2008 Allenspach EJ, Lemos MP, Porrett PM, Turka LA, Laufer TM. Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity. 29: 795-806. PMID 18951047 DOI: 10.1016/J.Immuni.2008.08.013  0.753
2008 Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. Journal of Immunology (Baltimore, Md. : 1950). 181: 3804-10. PMID 18768833 DOI: 10.4049/Jimmunol.181.6.3804  0.706
2008 Buckler JL, Liu X, Turka LA. Regulation of T-cell responses by PTEN. Immunological Reviews. 224: 239-48. PMID 18759931 DOI: 10.1111/J.1600-065X.2008.00650.X  0.509
2008 Seyfert-Margolis V, Turka LA. Marking a path to transplant tolerance. The Journal of Clinical Investigation. 118: 2684-6. PMID 18654643 DOI: 10.1172/Jci36552  0.305
2008 Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Ansari JM, Hancock WW, Sayegh MH, Koulmanda M, Strom TB, Turka LA. Mechanisms underlying blockade of allograft acceptance by TLR ligands. Journal of Immunology (Baltimore, Md. : 1950). 181: 1692-9. PMID 18641305 DOI: 10.4049/Jimmunol.181.3.1692  0.756
2008 LaRosa DF, Stumhofer JS, Gelman AE, Rahman AH, Taylor DK, Hunter CA, Turka LA. T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America. 105: 3855-60. PMID 18308927 DOI: 10.1073/Pnas.0706663105  0.724
2008 Bloom DD, Chang Z, Fechner JH, Dar WA, Polster SP, Pascual J, Turka LA, Knechtle SJ. CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. American Journal of Transplantation. 8: 793-802. PMID 18261176 DOI: 10.1111/J.1600-6143.2007.02134.X  0.529
2008 Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, et al. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. The Journal of Clinical Investigation. 118: 742-51. PMID 18172549 DOI: 10.1172/Jci32451  0.506
2008 King CG, Buckler JL, Kobayashi T, Hannah JR, Bassett G, Kim T, Pearce EL, Kim GG, Turka LA, Choi Y. Cutting edge: requirement for TRAF6 in the induction of T cell anergy. Journal of Immunology (Baltimore, Md. : 1950). 180: 34-8. PMID 18097000 DOI: 10.4049/Jimmunol.180.1.34  0.607
2008 Turka LA, Walsh PT. IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Frontiers in Bioscience : a Journal and Virtual Library. 13: 1440-6. PMID 17981641 DOI: 10.2741/2773  0.497
2008 Newell K, Asare A, Kirk A, Gisler T, Suthanthiran M, Burlingham W, Marks W, Turka L, Seyfert-Margolis V. A UNIQUE B CELL SIGNATURE ASSOCIATED WITH OPERATIONAL TOLERANCE Transplantation. 86: 73. DOI: 10.1097/01.Tp.0000332602.15945.Ff  0.302
2007 Yang J, Brook MO, Carvalho-Gaspar M, Zhang J, Ramon HE, Sayegh MH, Wood KJ, Turka LA, Jones ND. Allograft rejection mediated by memory T cells is resistant to regulation. Proceedings of the National Academy of Sciences of the United States of America. 104: 19954-9. PMID 18042727 DOI: 10.1073/Pnas.0704397104  0.589
2007 Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O'Shea JJ, Hunter CA. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nature Immunology. 8: 1363-71. PMID 17994025 DOI: 10.1038/Ni1537  0.742
2007 Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, Wells AD, Hancock WW. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nature Medicine. 13: 1299-307. PMID 17922010 DOI: 10.1038/Nm1652  0.743
2007 Dzierszinski F, Pepper M, Stumhofer JS, LaRosa DF, Wilson EH, Turka LA, Halonen SK, Hunter CA, Roos DS. Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infection and Immunity. 75: 5200-9. PMID 17846116 DOI: 10.1128/Iai.00954-07  0.697
2007 Schrum AG, Gil D, Dopfer EP, Wiest DL, Turka LA, Schamel WW, Palmer E. High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Science's Stke : Signal Transduction Knowledge Environment. 2007: pl2. PMID 17551170 DOI: 10.1126/Stke.3892007Pl2  0.675
2007 LaRosa DF, Rahman AH, Turka LA. The innate immune system in allograft rejection and tolerance. Journal of Immunology (Baltimore, Md. : 1950). 178: 7503-9. PMID 17548582 DOI: 10.4049/Jimmunol.178.12.7503  0.385
2007 LaRosa DF, Gelman AE, Rahman AH, Zhang J, Turka LA, Walsh PT. CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunology Letters. 108: 183-8. PMID 17270282 DOI: 10.1016/J.Imlet.2006.12.007  0.689
2007 Stumhofer JS, Silver J, Laurence A, Porrett PM, Turka LA, Ernst M, Saris CJ, O′Shea JJ, Hunter CA. 146 A Central Role for Interleukin 27 and IL-6 Mediated Activation of STAT3 in T Cell Production of IL-10 Cytokine. 39: 40-41. DOI: 10.1016/J.Cyto.2007.07.151  0.719
2006 Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity. 25: 783-93. PMID 17055754 DOI: 10.1016/J.Immuni.2006.08.023  0.662
2006 Buckler JL, Walsh PT, Porrett PM, Choi Y, Turka LA. Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. Journal of Immunology (Baltimore, Md. : 1950). 177: 4262-6. PMID 16982858 DOI: 10.4049/Jimmunol.177.7.4262  0.784
2006 King CG, Kobayashi T, Cejas PJ, Kim T, Yoon K, Kim GK, Chiffoleau E, Hickman SP, Walsh PT, Turka LA, Choi Y. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nature Medicine. 12: 1088-92. PMID 16921377 DOI: 10.1038/Nm1449  0.59
2006 Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA. PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. The Journal of Clinical Investigation. 116: 2521-31. PMID 16917540 DOI: 10.1172/Jci28057  0.779
2006 Taylor DK, Walsh PT, LaRosa DF, Zhang J, Burchill MA, Farrar MA, Turka LA. Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis. Journal of Immunology (Baltimore, Md. : 1950). 177: 2216-23. PMID 16887981 DOI: 10.4049/Jimmunol.177.4.2216  0.579
2006 Hickman SP, Yang J, Thomas RM, Wells AD, Turka LA. Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 2186-94. PMID 16887978 DOI: 10.4049/Jimmunol.177.4.2186  0.515
2006 Benigni A, Tomasoni S, Turka LA, Longaretti L, Zentilin L, Mister M, Pezzotta A, Azzollini N, Noris M, Conti S, Abbate M, Giacca M, Remuzzi G. Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection. Journal of the American Society of Nephrology : Jasn. 17: 1665-72. PMID 16641148 DOI: 10.1681/Asn.2006010090  0.354
2006 Neujahr DC, Chen C, Huang X, Markmann JF, Cobbold S, Waldmann H, Sayegh MH, Hancock WW, Turka LA. Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. Journal of Immunology (Baltimore, Md. : 1950). 176: 4632-9. PMID 16585554 DOI: 10.4049/Jimmunol.176.8.4632  0.569
2006 Bluestone JA, St Clair EW, Turka LA. CTLA4Ig: bridging the basic immunology with clinical application. Immunity. 24: 233-8. PMID 16546089 DOI: 10.1016/J.Immuni.2006.03.001  0.303
2006 Vu MD, Clarkson MR, Yagita H, Turka LA, Sayegh MH, Li XC. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. Journal of Immunology (Baltimore, Md. : 1950). 176: 1394-401. PMID 16424166 DOI: 10.4049/Jimmunol.176.3.1394  0.546
2006 Walsh PT, Benoit BM, Wysocka M, Dalton NM, Turka LA, Rook AH. A role for regulatory T cells in cutaneous T-Cell lymphoma; induction of a CD4 + CD25 + Foxp3+ T-cell phenotype associated with HTLV-1 infection. The Journal of Investigative Dermatology. 126: 690-2. PMID 16410788 DOI: 10.1038/Sj.Jid.5700121  0.576
2006 Sánchez-Fueyo A, Sandner S, Habicht A, Mariat C, Kenny J, Degauque N, Zheng XX, Strom TB, Turka LA, Sayegh MH. Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. Journal of Immunology (Baltimore, Md. : 1950). 176: 329-34. PMID 16365425 DOI: 10.4049/Jimmunol.176.1.329  0.588
2006 LaRosa D, Gelman A, Turka L. CD4 T Cells Receive Costimulatory Signals from CpG DNA during Antigen-Specific Stimulation Journal of Allergy and Clinical Immunology. 117: S177. DOI: 10.1016/J.Jaci.2005.12.708  0.662
2005 Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, Freedman BD, Turka LA. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 102: 17071-6. PMID 16286658 DOI: 10.1073/Pnas.0506070102  0.698
2005 Krupnick AS, Gelman AE, Barchet W, Richardson S, Kreisel FH, Turka LA, Colonna M, Patterson GA, Kreisel D. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 175: 6265-70. PMID 16272276 DOI: 10.4049/Jimmunol.175.10.6265  0.709
2005 Hickman SP, Turka LA. Homeostatic T cell proliferation as a barrier to T cell tolerance. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 360: 1713-21. PMID 16147536 DOI: 10.1098/Rstb.2005.1699  0.571
2005 Schenk S, Kish DD, He C, El-Sawy T, Chiffoleau E, Chen C, Chen C, Wu Z, Sandner S, Gorbachev AV, Fukamachi K, Heeger PS, Sayegh MH, Turka LA, Fairchild RL. Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+ CD25+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 174: 3741-8. PMID 15749914 DOI: 10.4049/Jimmunol.174.6.3741  0.481
2005 Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Domenig C, Habicht A, Najafian N, Yagita H, Azuma M, Turka LA, Sayegh MH. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. Journal of Immunology (Baltimore, Md. : 1950). 174: 3408-15. PMID 15749874 DOI: 10.4049/Jimmunol.174.6.3408  0.353
2005 Schrum AG, Palmer E, Turka LA. Distinct temporal programming of naive CD4+ T cells for cell division versus TCR-dependent death susceptibility by antigen-presenting macrophages. European Journal of Immunology. 35: 449-59. PMID 15682456 DOI: 10.1002/Eji.200425635  0.772
2005 Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Yagita H, Turka LA, Sayegh MH. Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 5: 31-9. PMID 15636609 DOI: 10.1111/J.1600-6143.2004.00640.X  0.596
2005 Neujahr D, Turka LA. Lymphocyte depletion as a barrier to immunological tolerance. Contributions to Nephrology. 146: 65-72. PMID 15567921 DOI: 10.1159/000082066  0.47
2005 LaRosa D, Gelman A, Turka L. Oligonucleotide costimulation of mouse CD4+ T cell proliferation is dependent on the Toll-like receptor adaptor molecule MyD88 Journal of Allergy and Clinical Immunology. 115: S270. DOI: 10.1016/J.Jaci.2004.12.1089  0.678
2005 Sandner SE, Sanchez-Fueyo A, Turka LA, Strom TB, Sayegh MH. CD4+ CD25+ regulatory T cells mediate antigen-specificity in a novel TCR transgenic model of alloimmunity Journal of Heart and Lung Transplantation. 24. DOI: 10.1016/J.Healun.2004.11.199  0.311
2004 Walsh PT, Taylor DK, Turka LA. Tregs and transplantation tolerance. The Journal of Clinical Investigation. 114: 1398-403. PMID 15545987 DOI: 10.1172/Jci23238  0.46
2004 Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Molecular and Cellular Biology. 24: 9038-47. PMID 15456877 DOI: 10.1128/Mcb.24.20.9038-9047.2004  0.8
2004 Taylor DK, Neujahr D, Turka LA. Heterologous immunity and homeostatic proliferation as barriers to tolerance. Current Opinion in Immunology. 16: 558-64. PMID 15341999 DOI: 10.1016/J.Coi.2004.07.007  0.509
2004 Kreisel D, Krasinskas AM, Krupnick AS, Gelman AE, Balsara KR, Popma SH, Riha M, Rosengard AM, Turka LA, Rosengard BR. Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. Journal of Immunology (Baltimore, Md. : 1950). 173: 3027-34. PMID 15322162 DOI: 10.4049/Jimmunol.173.5.3027  0.607
2004 Gelman AE, Zhang J, Choi Y, Turka LA. Toll-like receptor ligands directly promote activated CD4+ T cell survival. Journal of Immunology (Baltimore, Md. : 1950). 172: 6065-73. PMID 15128790 DOI: 10.4049/Jimmunol.172.10.6065  0.683
2004 Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 172: 5287-96. PMID 15100267 DOI: 10.4049/Jimmunol.172.9.5287  0.728
2004 Walsh PT, Strom TB, Turka LA. Routes to transplant tolerance versus rejection; the role of cytokines. Immunity. 20: 121-31. PMID 14975235 DOI: 10.1016/S1074-7613(04)00024-X  0.398
2004 Guillonneau C, Louvet C, Renaudin K, Heslan JM, Heslan M, Tesson L, Vignes C, Guillot C, Choi Y, Turka LA, Cuturi MC, Anegon I, Josien R. The role of TNF-related activation-induced cytokine-receptor activating NF-kappa B interaction in acute allograft rejection and CD40L-independent chronic allograft rejection. Journal of Immunology (Baltimore, Md. : 1950). 172: 1619-29. PMID 14734743 DOI: 10.4049/Jimmunol.172.3.1619  0.385
2004 Mata M, Chiffoleau E, Adler SH, Gray T, Hancock W, Turka LA. Bcl-XL expression in stem cells facilitates engraftment and reduces the need for host conditioning during bone marrow transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 4: 58-64. PMID 14678035 DOI: 10.1046/J.1600-6143.2003.00305.X  0.367
2004 Wu Z, Bensinger SJ, Zhang J, Chen C, Yuan X, Huang X, Markmann JF, Kassaee A, Rosengard BR, Hancock WW, Sayegh MH, Turka LA. Homeostatic proliferation is a barrier to transplantation tolerance. Nature Medicine. 10: 87-92. PMID 14647496 DOI: 10.1038/Nm965  0.759
2004 Kurtz J, Lie A, Griffith M, Eysaman S, Shaffer J, Anosova N, Turka L, Benichou G, Sykes M. Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 3: 804-16. PMID 12814472 DOI: 10.1034/J.1600-6143.2003.00128.X  0.596
2004 Sandner SE, Sanchez-Fueyo A, Domenig C, Zheng XX, Turka LA, Strom TB, Sayegh MH. Specificity And Function Of Cd4+ Cd25+ Regulatory T Cells In A Novel Cd4+ Tcr-Transgenic Model Of Alloimmunity Transplantation. 78: 70-71. DOI: 10.1097/00007890-200407271-00193  0.486
2003 Gelman AE, Turka LA. Autoimmunity heats up. Nature Medicine. 9: 1465-6. PMID 14647523 DOI: 10.1038/Nm1203-1465  0.498
2003 Burchill MA, Goetz CA, Prlic M, O'Neil JJ, Harmon IR, Bensinger SJ, Turka LA, Brennan P, Jameson SC, Farrar MA. Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 5853-64. PMID 14634095 DOI: 10.4049/Jimmunol.171.11.5853  0.774
2003 Chiffoleau E, Kobayashi T, Walsh MC, King CG, Walsh PT, Hancock WW, Choi Y, Turka LA. TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. Journal of Immunology (Baltimore, Md. : 1950). 171: 5751-9. PMID 14634083 DOI: 10.4049/Jimmunol.171.11.5751  0.491
2003 Schrum AG, Turka LA, Palmer E. Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. Immunological Reviews. 196: 7-24. PMID 14617194 DOI: 10.1046/J.1600-065X.2003.00083.X  0.746
2003 Sandner SE, Salama AD, Houser SL, Palmer E, Turka LA, Sayegh MH. New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo American Journal of Transplantation. 3: 1242-1250. PMID 14510697 DOI: 10.1046/J.1600-6143.2003.00220.X  0.593
2003 Kobayashi T, Walsh PT, Walsh MC, Speirs KM, Chiffoleau E, King CG, Hancock WW, Caamano JH, Hunter CA, Scott P, Turka LA, Choi Y. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity. 19: 353-63. PMID 14499111 DOI: 10.1016/S1074-7613(03)00230-9  0.578
2003 Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, Wolfe MS, Turka LA, Pear WS. Notch signaling augments T cell responsiveness by enhancing CD25 expression. Journal of Immunology (Baltimore, Md. : 1950). 171: 2896-903. PMID 12960312 DOI: 10.4049/Jimmunol.171.6.2896  0.588
2003 Chung JB, Wells AD, Adler S, Jacob A, Turka LA, Monroe JG. Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. Journal of Immunology (Baltimore, Md. : 1950). 171: 1758-67. PMID 12902475 DOI: 10.4049/Jimmunol.171.4.1758  0.546
2003 Chiffoleau E, Walsh PT, Turka L. Apoptosis and transplantation tolerance. Immunological Reviews. 193: 124-145. PMID 12752677 DOI: 10.1034/J.1600-065X.2003.00037.X  0.53
2003 Sayegh MH, Wu Z, Hancock WW, Langmuir PB, Mata M, Sandner S, Kishimoto K, Sho M, Palmer E, Mitchell RN, Turka LA. Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 3: 381-9. PMID 12694059 DOI: 10.1034/J.1600-6143.2003.00062.X  0.454
2003 Wells AD, Liu QH, Hondowicz B, Zhang J, Turka LA, Freedman BD. Regulation of T cell activation and tolerance by phospholipase C gamma-1-dependent integrin avidity modulation. Journal of Immunology (Baltimore, Md. : 1950). 170: 4127-33. PMID 12682243 DOI: 10.4049/Jimmunol.170.8.4127  0.587
2003 Lechler RI, Garden OA, Turka LA. The complementary roles of deletion and regulation in transplantation tolerance. Nature Reviews Immunology. 3: 147-158. PMID 12563298 DOI: 10.1038/Nri1002  0.41
2003 Sandner S, Salama A, Palmer E, Turka LA, Sayegh MH. Visualization of alloreactive CD4 T cell responses and tolerance induction in vivo Journal of Heart and Lung Transplantation. 22. DOI: 10.1016/S1053-2498(02)00966-X  0.531
2002 Kreisel D, Krupnick AS, Balsara KR, Riha M, Gelman AE, Popma SH, Szeto WY, Turka LA, Rosengard BR. Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. Journal of Immunology (Baltimore, Md. : 1950). 169: 6154-61. PMID 12444119 DOI: 10.4049/Jimmunol.169.11.6154  0.696
2002 Liu QH, Fleischmann BK, Hondowicz B, Maier CC, Turka LA, Yui K, Kotlikoff MI, Wells AD, Freedman BD. Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. The Journal of Experimental Medicine. 196: 897-909. PMID 12370252 DOI: 10.1084/Jem.20020381  0.491
2002 Krupnick AS, Kreisel D, Popma SH, Balsara KR, Szeto WY, Krasinskas AM, Riha M, Wells AD, Turka LA, Rosengard BR. Mechanism of T cell-mediated endothelial apoptosis. Transplantation. 74: 871-6. PMID 12364869 DOI: 10.1097/00007890-200209270-00022  0.463
2002 Schrum AG, Turka LA. The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering. The Journal of Experimental Medicine. 196: 793-803. PMID 12235212 DOI: 10.1084/Jem.20020158  0.774
2002 Adler SH, Turka LA. Immunotherapy as a means to induce transplantation tolerance. Current Opinion in Immunology. 14: 660-5. PMID 12183169 DOI: 10.1016/S0952-7915(02)00376-X  0.429
2002 Kreisel D, Sankaran D, Wells AD, Turka LA. Interleukin-2-mediated survival and proliferative signals are uncoupled in T lymphocytes that fail to divide after activation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2: 120-8. PMID 12099513 DOI: 10.1034/J.1600-6143.2002.020202.X  0.531
2002 Kishimoto K, Sandner S, Imitola J, Sho M, Li Y, Langmuir PB, Rothstein DM, Strom TB, Turka LA, Sayegh MH. Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. The Journal of Clinical Investigation. 109: 1471-9. PMID 12045261 DOI: 10.1172/Jci14947  0.551
2002 Seo SJ, Fields ML, Buckler JL, Reed AJ, Mandik-Nayak L, Nish SA, Noelle RJ, Turka LA, Finkelman FD, Caton AJ, Erikson J. The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells. Immunity. 16: 535-46. PMID 11970877 DOI: 10.1016/S1074-7613(02)00298-4  0.567
2002 Makino Y, Cook DN, Smithies O, Hwang OY, Neilson EG, Turka LA, Sato H, Wells AD, Danoff TM. Impaired T cell function in RANTES-deficient mice. Clinical Immunology (Orlando, Fla.). 102: 302-9. PMID 11890717 DOI: 10.1006/Clim.2001.5178  0.54
2002 Kreisel D, Krupnick AS, Gelman AE, Engels FH, Popma SH, Krasinskas AM, Balsara KR, Szeto WY, Turka LA, Rosengard BR. Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognition. Nature Medicine. 8: 233-9. PMID 11875493 DOI: 10.1038/Nm0302-233  0.722
2002 Adler SH, Bensinger SJ, Turka LA. Stemming the tide of rejection. Nature Medicine. 8: 107-8. PMID 11821887 DOI: 10.1038/Nm0202-107  0.641
2001 Li XC, Wells AD, Turka LA, Strom TB. Death of alloreactive T cells sets the stage for immunoregulation to act. Transplantation Proceedings. 33: 3041-3. PMID 11750313 DOI: 10.1016/S0041-1345(01)02302-8  0.578
2001 Gudmundsdottir H, Turka LA. A closer look at homeostatic proliferation of CD4+ T cells: costimulatory requirements and role in memory formation. Journal of Immunology (Baltimore, Md. : 1950). 167: 3699-707. PMID 11564785 DOI: 10.4049/Jimmunol.167.7.3699  0.812
2001 Wells AD, Walsh MC, Bluestone JA, Turka LA. Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. The Journal of Clinical Investigation. 108: 895-903. PMID 11560959 DOI: 10.1172/Jci13220  0.596
2001 Yamada A, Kishimoto K, Dong VM, Sho M, Salama AD, Anosova NG, Benichou G, Mandelbrot DA, Sharpe AH, Turka LA, Auchincloss H, Sayegh MH. CD28-independent costimulation of T cells in alloimmune responses. Journal of Immunology (Baltimore, Md. : 1950). 167: 140-6. PMID 11418642 DOI: 10.4049/Jimmunol.167.1.140  0.515
2001 Wells AD, Li XC, Strom TB, Turka LA. The role of peripheral T-cell deletion in transplantation tolerance. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356: 617-23. PMID 11375065 DOI: 10.1098/Rstb.2001.0845  0.515
2001 Csizmadia V, Gao W, Hancock SA, Rottman JB, Wu Z, Turka LA, Siebenlist U, Hancock WW. Differential NF-kappaB and IkappaB gene expression during development of cardiac allograft rejection versus CD154 monoclonal antibody-induced tolerance. Transplantation. 71: 835-40. PMID 11349713 DOI: 10.1097/00007890-200104150-00003  0.374
2001 Li XC, Strom TB, Turka LA, Wells AD. T cell death and transplantation tolerance. Immunity. 14: 407-16. PMID 11336686 DOI: 10.1016/S1074-7613(01)00121-2  0.552
2001 Eck SC, Turka LA. Adoptive transfer enables tumor rejection targeted against a self-antigen without the induction of autoimmunity. Cancer Research. 61: 3077-83. PMID 11306490  0.754
2001 Kim KS, Denton MD, Chandraker A, Knoflach A, Milord R, Waaga AM, Turka LA, Russell ME, Peach R, Sayegh MH. CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis. The American Journal of Pathology. 158: 977-86. PMID 11238045 DOI: 10.1016/S0002-9440(10)64044-8  0.536
2001 Wekerle T, Kurtz J, Sayegh M, Ito H, Wells A, Bensinger S, Shaffer J, Turka L, Sykes M. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. Journal of Immunology (Baltimore, Md. : 1950). 166: 2311-6. PMID 11160287 DOI: 10.4049/Jimmunol.166.4.2311  0.713
2001 Suchin EJ, Langmuir PB, Palmer E, Sayegh MH, Wells AD, Turka LA. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. Journal of Immunology (Baltimore, Md. : 1950). 166: 973-81. PMID 11145675 DOI: 10.4049/Jimmunol.166.2.973  0.528
2001 Rosengard BR, Turka LA. The tolerant recipient: looking great in someone else’s genes Journal of Clinical Investigation. 107: 33-34. PMID 11134177 DOI: 10.1172/Jci11969  0.417
2000 Li XC, Wells AD, Strom TB, Turka LA. The role of T cell apoptosis in transplantation tolerance. Current Opinion in Immunology. 12: 522-7. PMID 11007354 DOI: 10.1016/S0952-7915(00)00133-3  0.561
2000 Smiley ST, Csizmadia V, Gao W, Turka LA, Hancock WW. Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance induction. Transplantation. 70: 415-9. PMID 10949181 DOI: 10.1097/00007890-200008150-00005  0.492
2000 Wells AD, Walsh MC, Sankaran D, Turka LA. T cell effector function and anergy avoidance are quantitatively linked to cell division. Journal of Immunology (Baltimore, Md. : 1950). 165: 2432-43. PMID 10946268 DOI: 10.4049/Jimmunol.165.5.2432  0.593
2000 Schrum AG, Wells AD, Turka LA. Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation. International Immunology. 12: 833-42. PMID 10837411 DOI: 10.1093/Intimm/12.6.833  0.76
2000 Issazadeh S, Abdallah K, Chitnis T, Chandraker A, Wells AD, Turka LA, Sayegh MH, Khoury SJ. Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis. The Journal of Clinical Investigation. 105: 1109-16. PMID 10772655 DOI: 10.1172/Jci8607  0.37
2000 Gudmundsdottir H, Turka LA. Transplantation tolerance: mechanisms and strategies? Seminars in Nephrology. 20: 209-16. PMID 10746862  0.744
2000 Ozkaynak E, Gao W, Csizmadia V, King JA, Turka LA, Hancock WW. INTRAGRAFT EXPRESSION OF SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STATS) AND SUPPRESSORS OF CYTOKINE SYNTHESIS (SOCS) MOLECULES IN REJECTION VS. TOLERANCE. Transplantation. 69: S415. DOI: 10.1097/00007890-200004271-01161  0.314
2000 Suchin EJ, Sayegh MH, Wells AD, Turka LA. DETERMINATION OF THE ALLOREACTIVE T CELL FREQUENCY IN VIVO: WHAT YOU GET DEPENDS UPON WHAT YOU MEASURE.: Abstract# 151 Transplantation. 69. DOI: 10.1097/00007890-200004271-00151  0.435
2000 Kishimoto K, Chitnis T, Khoury SJ, Li XC, Strom TB, Wells AD, Turka LA, Sayegh MH. PASSIVE T CELL DEATH IS NOT REQUIRED FOR INDUCTION OF TRANSPLANTATION TOLERANCE TO MINOR HISTOCOMPATIBILITY ANTIGENS MISMATCHED ALLOGRAFTS. Transplantation. 69: S147. DOI: 10.1097/00007890-200004271-00134  0.489
2000 Schrum AG, Pradhan M, Wells AD, Turka LA. REGULATION OF TCR SURFACE EXPRESSION DURING T CELL ACTIVATION: A NEW MECHANISM OF ACTION OF CD28 COSTIMULATION.: Abstract# 75 Transplantation. 69. DOI: 10.1097/00007890-200004271-00075  0.756
2000 Wells AD, Walsh MC, Sankaran D, Turka LA. CD28 COSTIMULATION AND CELL CYCLE PROGRESSION ARE TOGETHER NECESSARY AND SUFFICIENT FOR ANERGY AVOIDANCE IN PRIMARY CD4+ T CELLS.: Abstract# 71 Transplantation. 69. DOI: 10.1097/00007890-200004271-00071  0.527
1999 Khoury S, Sayegh MH, Turka LA. Blocking costimulatory signals to induce transplantation tolerance and prevent autoimmune disease. International Reviews of Immunology. 18: 185-99. PMID 10614723 DOI: 10.3109/08830189909043024  0.408
1999 Wells AD, Li XC, Li Y, Walsh MC, Zheng XX, Wu Z, Nuñez G, Tang A, Sayegh M, Hancock WW, Strom TB, Turka LA. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nature Medicine. 5: 1303-7. PMID 10545998 DOI: 10.1038/15260  0.532
1999 Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nature Medicine. 5: 1298-302. PMID 10545997 DOI: 10.1038/15256  0.603
1999 Rosengard AM, Alonso LC, Korb LC, Baldwin WM, Sanfilippo F, Turka LA, Ahearn JM. Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP) Molecular Immunology. 36: 685-697. PMID 10509819 DOI: 10.1016/S0161-5890(99)00081-4  0.342
1999 Chan SY, Li K, Piccotti JR, Louie MC, Judge TA, Turka LA, Eichwald EJ, Bishop DK. Tissue-specific consequences of the anti-adenoviral immune response: Implications for cardiac transplants Nature Medicine. 5: 1143-1149. PMID 10502817 DOI: 10.1038/13467  0.327
1999 Eck SC, Turka LA. Generation of protective immunity against an immunogenic carcinoma requires CD40/CD40L and B7/CD28 interactions but not CD4(+) T cells. Cancer Immunology, Immunotherapy : Cii. 48: 336-41. PMID 10473809 DOI: 10.1007/S002620050583  0.809
1999 Gudmundsdottir H, Turka LA. T cell costimulatory blockade: new therapies for transplant rejection. Journal of the American Society of Nephrology : Jasn. 10: 1356-65. PMID 10361876  0.81
1999 Gudmundsdottir H, Wells AD, Turka LA. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. Journal of Immunology (Baltimore, Md. : 1950). 162: 5212-23. PMID 10227995  0.798
1999 Wells A, Gudmundsdottir H, Walsh M, Turka LA. Single-cell analysis of T-cell responses in vitro and in vivo: role of costimulatory signals. Transplantation Proceedings. 31: 814-5. PMID 10083353 DOI: 10.1016/S0041-1345(98)01784-9  0.774
1999 Judge TA, Sayegh MH, Wu Z, Zheng X, Sharpe A, Turka LA. THE ROLE OF CTLA4-MEDIATED NEGATIVE SIGNALS AND CELL SURVIVAL IN TOLERANCE INDUCTION BY BLOCKADE OF B7:CD28 AND CD40:CD40L (CD154). Transplantation. 67: S235. DOI: 10.1097/00007890-199904150-00939  0.444
1999 Gudmundsdottir H, Wells AD, Walsh M, Turka LA. Examining Individual T Cells During In Vivo Responses: What Regulates Proliferation And Cytokine Production? Transplantation. 67. DOI: 10.1097/00007890-199904150-00909  0.766
1999 Dong VM, Chandraker A, Abdallah KA, Womer KL, Kishimoto K, Turka LA, Sayegh MH. Rat Cd28 Specific Monoclonal Antibody: Its Potential Role In Activation Induced Cell Death And Prevention Of Acute Vascularized Cardiac Allograft Rejection Transplantation. 67. DOI: 10.1097/00007890-199904150-00529  0.391
1999 Suchin EJ, Wells AD, Turka LA. What Is The Real Frequency Of Alloreactive T Cells Transplantation. 67. DOI: 10.1097/00007890-199904150-00076  0.443
1999 Wells AD, Walsh M, Turka LA. Defective Tcr Signal Transduction In Activated, But Non-Proliferative And Il-2 Refractory, T Cells. Transplantation. 67. DOI: 10.1097/00007890-199904150-00029  0.455
1998 Hancock WW, Buelow R, Sayegh MH, Turka LA. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nature Medicine. 4: 1392-6. PMID 9846576 DOI: 10.1038/3982  0.385
1998 Judge TA, Desai NM, Yang Z, Rostami S, Alonso L, Zhang H, Chen Y, Markman JF, DeMateo RP, Barker CF, Naji A, Turka LA. Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival. Transplantation. 66: 426-34. PMID 9734483 DOI: 10.1097/00007890-199808270-00003  0.394
1998 Zheng X-, Turka LA. Blocking T-cell costimulation to prevent transplant rejection. Transplantation Proceedings. 30: 2146-2149. PMID 9723421 DOI: 10.1016/S0041-1345(98)00568-5  0.487
1998 Boxhorn HKE, Smith JG, Chang YJ, Guerry D, Lee WMF, Rodeck U, Turka LA, Eck SL. Adenoviral transduction of melanoma cells with B7-1: antitumor immunity and immunosuppressive factors. Cancer Immunology, Immunotherapy. 46: 283-292. PMID 9690457 DOI: 10.1007/S002620050489  0.427
1998 Sayegh MH, Turka LA. The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection The New England Journal of Medicine. 338: 1813-1821. PMID 9632449 DOI: 10.1056/Nejm199806183382506  0.326
1998 Jooss K, Turka L, Wilson J. Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig Gene Therapy. 5: 309-319. PMID 9614550 DOI: 10.1038/Sj.Gt.3300595  0.51
1998 Wells AD, Turka LA. Individual T cells hold unexpected clues to the nature of anergy and memory. Immunologic Research. 17: 261-8. PMID 9479587 DOI: 10.1007/Bf02786450  0.522
1998 Tang A, Judge TA, Turka LA. Blockade of CD40-CD40 ligand pathway induces tolerance in murine contact hypersensitivity. European Journal of Immunology. 27: 3143-50. PMID 9464799 DOI: 10.1002/Eji.1830271210  0.506
1998 Olthoff KM, Judge TA, Gelman AE, Da Shen X, Hancock WW, Turka LA, Shaked A. Adenovirus-mediated gene transfer into cold-preserved liver allografts: Survival pattern and unresponsiveness following transduction with CTLA4Ig Nature Medicine. 4: 194-200. PMID 9461193 DOI: 10.1038/Nm0298-194  0.571
1998 Sayegh MH, Zheng XG, Magee C, Hancock WW, Turka LA. Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients. Transplantation. 64: 1646-50. PMID 9422396 DOI: 10.1097/00007890-199712270-00003  0.505
1998 Olthoff KM, Desai NM, Gelman AE, Hancock WW, Furth EE, Turka LA, Shaked A. PATTERN OF ALLORECOGNITION AND ACCEPTANCE OF SAME DONOR ALLOGRAFT FOLLOWING TOLERANCE INDUCED BY HEPATIC TRANSDUCTION WITH AdCTLA4Ig Transplantation. 66: S30. DOI: 10.1097/00007890-199810270-00147  0.509
1998 Olthoff KM, Gelman A, Shen X, Turka LA, Shaked A. LOCAL VS. SYSTEMIC IMMUNE INHIBITION FOLLOWING TRANSDUCTION OF LIVER ALLOGRAFTS WITH CTLA4IG Transplantation. 65: 187. DOI: 10.1097/00007890-199805131-00433  0.506
1998 Csizmadia V, Sevillano S, Turka L, Hancock WW. INTERRUPTION OF CD40/CD40L CO-STIMULATION ALTERS INTRAGRAFT CHEMOKINE EXPRESSION: REJECTION IS LINKED TO CXCR3+ CELLS AND LIGANDS IP-10 AND MIG WHEREAS LONG-TERM SURVIVAL IS ASSOCIATED WITH THEIR SUPPRESSION AND INFILTRATIOIN BY CCR2+ CELLS. Transplantation. 65: 166. DOI: 10.1097/00007890-199805131-00349  0.442
1998 Gudmundsdottir H, Wells AD, Walsh M, Turka LA. Examining Individual T Cells During An In Vivo Immune Response: How Does Cd28 Signalling Regulate Recruitment And Expansion? Transplantation. 65: 85. DOI: 10.1097/00007890-199805131-00028  0.794
1998 Wells AD, Walsh M, Turka LA. Two Distinct Forms Of T Cell Anergy Are Induced By Lack Of Costimulation Vs. Cell Division During Primary Activation. Transplantation. 65: 85. DOI: 10.1097/00007890-199805131-00026  0.512
1998 Wells AD, Walsh M, Sayegh MH, Turka LA. BCL-Xl AUGMENTS T CELL SURVIVAL IN THE ABSENCE OF COSTIMULATION AND BLOCKS IMMUNOSUPPRESSION WITH CTLA4IG. Transplantation. 65: 79. DOI: 10.1097/00007890-199805131-00002  0.491
1997 Wells AD, Gudmundsdottir H, Turka LA. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. The Journal of Clinical Investigation. 100: 3173-83. PMID 9399965 DOI: 10.1172/Jci119873  0.813
1997 Eck SC, Chang D, Wells AD, Turka LA. Differential down-regulation of CD28 by B7-1 and B7-2 engagement. Transplantation. 64: 1497-9. PMID 9392322 DOI: 10.1097/00007890-199711270-00025  0.814
1997 Zhang H, Yang Y, Horton JL, Samoilova EB, Judge TA, Turka LA, Wilson JM, Chen Y. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. The Journal of Clinical Investigation. 100: 1951-7. PMID 9329958 DOI: 10.1172/Jci119726  0.381
1997 Olthoff KM, Da Chen X, Gelman A, Turka L, Shaked A. Adenovirus-mediated gene transfer of CTLA4Ig to liver allografts results in prolonged survival and local T-cell anergy Transplantation Proceedings. 29: 1030-1031. PMID 9123183 DOI: 10.1016/S0041-1345(96)00355-7  0.601
1997 Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proceedings of the National Academy of Sciences of the United States of America. 93: 13967-72. PMID 8943044 DOI: 10.1073/Pnas.93.24.13967  0.501
1997 Aradhye S, Turka LA. Will Tolerance Become a Clinical Reality The American Journal of the Medical Sciences. 313: 310-314. DOI: 10.1016/S0002-9629(15)40122-3  0.314
1996 Akalin E, Chandraker A, Russell ME, Turka LA, Hancock WW, Sayegh MH. CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: Inhibition of cell-mediated and humoral immune responses in vivo Transplantation. 62: 1942-1945. PMID 8990393 DOI: 10.1097/00007890-199612270-00047  0.543
1996 Judge TA, Tang A, Turka LA. Immunosuppression through blockade of CD28:B7-mediated costimulatory signals. Immunologic Research. 15: 38-49. PMID 8739564 DOI: 10.1007/Bf02918283  0.58
1996 Bolling SF, Lin H, Turka LA. The Time Course of CTLA4Ig Effect on Cardiac Allograft Rejection Journal of Surgical Research. 63: 320-323. PMID 8661218 DOI: 10.1006/Jsre.1996.0268  0.539
1995 Judge TA, Liu M, Christensen PJ, Fak JJ, Turka LA. Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis. International Immunology. 7: 171-8. PMID 7537533 DOI: 10.1093/Intimm/7.2.171  0.391
1995 Sayegh MH, Akalin E, Hancock WW, Russell ME, Carpenter CB, Linsley PS, Turka LA. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. The Journal of Experimental Medicine. 181: 1869-74. PMID 7536798 DOI: 10.1084/Jem.181.5.1869  0.455
1995 Nickoloff BJ, Mitra RS, Turka LA, Nestle FO. Direct and Indirect Control of T-Cell Activation by Keratinocytes Journal of Investigative Dermatology. 105: S25-S29. DOI: 10.1038/Jid.1995.6  0.597
1995 Turka LA, Goodman RE, Rutkowski JL, Sima AA, Merry A, Mitra RS, Wrone-Smith T, Toews G, Strieter RM, Nickoloff BJ. Interleukin 12: a potential link between nerve cells and the immune response in inflammatory disorders. Molecular Medicine. 1: 690-699. DOI: 10.1007/Bf03401609  0.315
1994 Nickoloff BJ, Mitra RS, Green J, Shimizu Y, Thompson C, Turka LA. Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: relevance to psoriasis. Journal of Dermatological Science. 6: 127-33. PMID 8274458 DOI: 10.1016/0923-1811(93)90002-7  0.438
1994 Bolling SF, Lin H, Wei RQ, Linsley P, Turka LA. The effect of combination cyclosporine and CTLA4-Ig therapy on cardiac allograft survival. Journal of Surgical Research. 57: 60-64. PMID 8041150 DOI: 10.1006/Jsre.1994.1110  0.482
1994 Nestle FO, Turka LA, Nickoloff BJ. Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. The Journal of Clinical Investigation. 94: 202-9. PMID 8040262 DOI: 10.1172/Jci117308  0.454
1994 Nickoloff BJ, Turka LA. Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. Immunology Today. 15: 464-9. PMID 7945770 DOI: 10.1016/0167-5699(94)90190-2  0.54
1994 Gratiot-Deans J, Merino R, Nuñez G, Turka LA. Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival. Proceedings of the National Academy of Sciences of the United States of America. 91: 10685-9. PMID 7938012 DOI: 10.1073/Pnas.91.22.10685  0.513
1994 Nickoloff BJ, Fivenson DP, Kunkel SL, Strieter RM, Turka LA. Keratinocyte interleukin-10 expression is upregulated in tape-stripped skin, poison ivy dermatitis, and Sezary syndrome, but not in psoriatic plaques. Clinical Immunology and Immunopathology. 73: 63-8. PMID 7923918 DOI: 10.1006/Clin.1994.1170  0.338
1994 Gratiot-Deans J, Turka LA. New biologic immunosuppressive agents in transplantation. Current Opinion in Nephrology and Hypertension. 3: 596-601. PMID 7881982 DOI: 10.1097/00041552-199411000-00006  0.506
1994 Green JM, Zheng XG, Shimizu Y, Thompson CB, Turka LA. T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA-1-mediated events. European Journal of Immunology. 24: 265-72. PMID 7517362 DOI: 10.1002/Eji.1830240141  0.566
1994 Nestle FO, Thompson C, Shimizu Y, Turka LA, Nickoloff BJ. Costimulation of superantigen-activated T lymphocytes by autologous dendritic cells is dependent on B7. Cellular Immunology. 156: 220-9. PMID 7515331 DOI: 10.1006/Cimm.1994.1166  0.52
1994 Nickoloff BJ, Nestle FO, Zheng X, Turka LA. T Lymphocytes in Skin Lesions of Psoriasis and Mycosis Fungoides Express B7-1: A Ligand for CD28 Blood. 83: 2580-2586. DOI: 10.1182/Blood.V83.9.2580.Bloodjournal8392580  0.527
1993 Hanash SM, Strahler JR, Chan Y, Kuick R, Teichroew D, Neel JV, Hailat N, Keim DR, Gratiot-Deans J, Ungar D, Melhem R, Zhu XX, Andrews P, Lottspeich F, Eckerskorn C, ... ... Turka LA, et al. Data base analysis of protein expression patterns during T-cell ontogeny and activation Proceedings of the National Academy of Sciences of the United States of America. 90: 3314-3318. PMID 8475073 DOI: 10.1073/Pnas.90.8.3314  0.505
1993 Strahler JR, Zhu XX, Hora N, Wang YK, Andrews PC, Roseman NA, Neel JV, Turka L, Hanash SM. Maturation stage and proliferation-dependent expression of dUTPase in human T cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 4991-5. PMID 8389461 DOI: 10.1073/Pnas.90.11.4991  0.465
1993 Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 74: 597-608. PMID 8358789 DOI: 10.1016/0092-8674(93)90508-N  0.343
1993 Lin H, Bolling SF, Linsley PS, Wei RQ, Gordon D, Thompson CB, Turka LA. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. Journal of Experimental Medicine. 178: 1801-1806. PMID 8228826 DOI: 10.1084/Jem.178.5.1801  0.471
1993 Mitchell BS, Dayton JS, Turka LA, Thompson CB. IMP Dehydrogenase Inhibitors as Immunomodulators Annals of the New York Academy of Sciences. 685: 217-224. PMID 8103312 DOI: 10.1111/J.1749-6632.1993.Tb35869.X  0.434
1992 Paine R, Chavis A, Gaposchkin D, Christensen P, Mody CH, Turka LA, Toews GB. A factor secreted by a human pulmonary alveolar epithelial-like cell line blocks T-cell proliferation between G1 and S phase. American Journal of Respiratory Cell and Molecular Biology. 6: 658-66. PMID 1591014 DOI: 10.1165/Ajrcmb/6.6.658  0.416
1992 Gratiot-Deans J, Keim D, Strahler JR, Turka LA, Hanash S. Differential expression of Op18 phosphoprotein during human thymocyte maturation. Journal of Clinical Investigation. 90: 1576-1581. PMID 1401087 DOI: 10.1172/Jci116026  0.509
1992 Turka LA, Fletcher MC, Craighead N, Thompson CB, June CH. Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes. Proceedings of the National Academy of Sciences of the United States of America. 89: 8706-10. PMID 1382296 DOI: 10.1073/Pnas.89.18.8706  0.479
1992 Vandenberghe P, Freeman GJ, Nadler LM, Fletcher MC, Kamoun M, Turka LA, Ledbetter JA, Thompson CB, June CH. Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. The Journal of Experimental Medicine. 175: 951-60. PMID 1372649 DOI: 10.1084/Jem.175.4.951  0.522
1992 Turka LA, Kanner SB, Schieven GL, Thompson CB, Ledbetter JA. CD45 modulates T cell receptor/CD3-induced activation of human thymocytes via regulation of tyrosine phosphorylation. European Journal of Immunology. 22: 551-7. PMID 1371471 DOI: 10.1002/Eji.1830220238  0.463
1992 Turka LA, Linsley PS, Lin H, Brady W, Leiden JM, Wei RQ, Gibson ML, Zheng XG, Myrdal S, Gordon D. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proceedings of the National Academy of Sciences of the United States of America. 89: 11102-5. PMID 1332070 DOI: 10.1073/Pnas.89.22.11102  0.601
1992 Green JM, Turka LA, June CH, Thompson CB. CD28 and staphylococcal enterotoxins synergize to induce MHC-independent T-cell proliferation. Cellular Immunology. 145: 11-20. PMID 1330329 DOI: 10.1016/0008-8749(92)90308-C  0.584
1991 Turka LA, Dayton J, Sinclair G, Thompson CB, Mitchell BS. Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine. The Journal of Clinical Investigation. 87: 940-8. PMID 1999502 DOI: 10.1172/Jci115101  0.521
1991 Paine R, Mody CH, Chavis A, Spahr MA, Turka LA, Toews GB. Alveolar epithelial cells block lymphocyte proliferation in vitro without inhibiting activation. American Journal of Respiratory Cell and Molecular Biology. 5: 221-9. PMID 1910808 DOI: 10.1165/Ajrcmb/5.3.221  0.449
1991 Turka LA, Schatz DG, Oettinger MA, Chun JJ, Gorka C, Lee K, McCormack WT, Thompson CB. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (New York, N.Y.). 253: 778-81. PMID 1831564 DOI: 10.1126/Science.1831564  0.516
1991 Turka LA, Thompson CB. Structure-function relationship of immunosuppressive drugs: A cautionary tale. Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL. Probing immunosuppressant action with a nonnatural immunophilin ligand Hepatology. 14: 570-572. PMID 1714876 DOI: 10.1002/Hep.1840140326  0.363
1990 Guba SC, Stella G, Turka LA, June CH, Thompson CB, Emerson SG. Regulation of interleukin 3 gene induction in normal human T cells. The Journal of Clinical Investigation. 84: 1701-6. PMID 2556442 DOI: 10.1172/Jci114352  0.523
1990 Tanaka K, Turka LA, Kupiec-Weglinski JW, Milford EL, Ueda H, Diamantstein T, Carpenter CB, Tilney NL. Evidence that monoclonal antibodies against the 55kD subunit of the rat IL-2 receptor do not inhibit the development of suppressor cells generated in mixed lymphocyte culture. Transplantation. 50: 125-31. PMID 2142344 DOI: 10.1097/00007890-199007000-00023  0.39
1989 Sayegh MH, Turka LA, Milford EL, Carpenter CB. Mixed lymphocyte response—generated suppressor cell specificity in humans is major histocompatibility complex—restricted Human Immunology. 26: 281-287. PMID 2531132 DOI: 10.1016/0198-8859(89)90006-2  0.399
1989 Ramos EL, Turka LA, Leggat JE, Wood IG, Milford EL, Carpenter CB. Decrease in phenotypically defined T helper inducer cells (T4+4B4+) and increase in T suppressor effector cells (T8+2H4+) in stable renal allograft recipients. Transplantation. 47: 465-471. PMID 2522253 DOI: 10.1097/00007890-198903000-00013  0.464
1989 Turka LA, Carpenter CB, Yunis EJ, Milford EL. Selective sparing of suppressor cells generated in mixed lymphocyte response by an anti-interleukinn-2 receptor antibody Transplantation. 47: 182-188. PMID 2521408 DOI: 10.1097/00007890-198901000-00038  0.415
1987 Turka LA, Ramos EL, Leggat JE, Milford EL, Fraser PA, Carpenter CB. Antigen specificity of mixed lymphocyte response-induced suppressor cells. Human Immunology. 20: 293-306. PMID 2449412 DOI: 10.1016/0198-8859(87)90020-6  0.365
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