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Lucio Hernan Castilla - Publications

Affiliations: 
University Of Massachusetts Med Sch Worcester 
Area:
Cancer research
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ahmad MH, Hegde M, Wong WJ, M Hosseini M, Garrett LJ, Carrascoso A, Issac N, Ebert BL, Silva JC, Pihan G, Zhu LJ, Wolfe S, Agarwal A, Liu PP, Castilla LH. Runx1-R188Q germline mutation induces inflammation and predisposition to hematologic malignancies in mice. Blood Advances. PMID 37756546 DOI: 10.1182/bloodadvances.2023010398  0.398
2023 Zezulin AU, Yen D, Ye D, Howell ED, Bresciani E, Diemer J, Ren JG, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W, et al. RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes & Development. PMID 37536952 DOI: 10.1101/gad.350418.123  0.309
2021 van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, et al. Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter. Blood. PMID 34010414 DOI: 10.1182/blood.2020008971  0.411
2020 van der Kouwe E, Heller G, Czibere A, Castilla LH, Delwel R, Di Ruscio A, Ebralidze A, Forte M, Kazianka L, Kornauth C, Le T, Lind K, Barbosa I, Pichler A, Pulikkan J, et al. Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells Blood. 136: 40-41. DOI: 10.1182/BLOOD-2020-140776  0.427
2020 Felcher CM, Tocci JM, Sola MEG, Bushweller JH, Castilla LH, Kordon EC. Abstract 5041: Inhibition of RUNX-CBFβ binding reduces RSPO3 expression and EMT features in breast cancer cells Tumor Biology. DOI: 10.1158/1538-7445.Am2020-5041  0.345
2018 Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 174: 1325. PMID 30142347 DOI: 10.1016/j.cell.2018.08.014  0.755
2018 Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 174: 172-186.e21. PMID 29958106 DOI: 10.1016/J.Cell.2018.05.048  0.804
2018 Pulikkan JA, Castilla LH. Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia. Frontiers in Oncology. 8: 129-129. PMID 29755956 DOI: 10.3389/Fonc.2018.00129  0.799
2017 Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, ... ... Castilla LH, et al. Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131]. Ebiomedicine. PMID 29104075 DOI: 10.1016/J.Ebiom.2017.10.029  0.742
2017 Choi A, Illendula A, Pulikkan JA, Roderick JE, Tesell J, Yu J, Hermance N, Zhu LJ, Castilla LH, Bushweller JH, Kelliher MA. RUNX1 is required for oncogenic Myb and Myc enhancer activity in T cell acute lymphoblastic leukemia. Blood. PMID 28790107 DOI: 10.1182/Blood-2017-03-775536  0.783
2017 Castilla LH, Bushweller JH. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia. Advances in Experimental Medicine and Biology. 962: 229-244. PMID 28299661 DOI: 10.1007/978-981-10-3233-2_15  0.503
2016 Illendula A, Gilmour J, Grembecka J, Tirumala VS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, ... ... Castilla LH, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. Ebiomedicine. 8: 117-131. PMID 27428424 DOI: 10.1016/J.Ebiom.2016.04.032  0.785
2016 Pelzer BW, Hollenbeck A, Weber S, Opalka B, Castilla LH, Dührsen U, Göthert JR. HIF-1α Promotes Cbfbeta-SMMHC-Induced Acute Myeloid Leukemia Development Blood. 128: 1559-1559. DOI: 10.1182/Blood.V128.22.1559.1559  0.412
2016 Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, ... ... Castilla LH, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers Ebiomedicine. DOI: 10.1016/j.ebiom.2016.04.032  0.374
2015 Recouvreux MS, Grasso EN, Echeverria PC, Rocha-Viegas L, Castilla LH, Schere-Levy C, Tocci JM, Kordon EC, Rubinstein N. RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes. Oncotarget. PMID 26735887 DOI: 10.18632/Oncotarget.6771  0.406
2015 Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science (New York, N.Y.). 347: 779-84. PMID 25678665 DOI: 10.1126/Science.Aaa0314  0.803
2014 Xue L, Pulikkan JA, Valk PJ, Castilla LH. NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis. Blood. 124: 426-36. PMID 24894773 DOI: 10.1182/Blood-2013-12-541730  0.81
2014 Pulikkan JA, Illendula A, Grembecka J, Xue L, Rajewski R, Guzman ML, Bushweller JH, Castilla LH. Selective Inhibition of the Leukemia Fusion Protein CBFβ-SMMHC By Small Molecule AI-10-49 in the Treatment of Inv(16) AML Blood. 124: 390-390. DOI: 10.1182/Blood.V124.21.390.390  0.559
2013 Naipauer J, Gattelli A, Degese MS, Slomiansky V, Wertheimer E, LaMarre J, Castilla L, Abba M, Kordon EC, Coso OA. The use of alternative polyadenylation sites renders integrin β1 (Itgb1) mRNA isoforms with differential stability during mammary gland development. The Biochemical Journal. 454: 345-57. PMID 23789592 DOI: 10.1042/Bj20130062  0.353
2013 Pulikkan JA, Liting X, Gerstein R, Socolovsky M, Castilla LH. Deletion Of Core Binding Factors Runx1 and Runx2 Leads To Perturbed Hematopoiesis In Multiple Lineages Blood. 122: 46-46. DOI: 10.1182/Blood.V122.21.46.46  0.5
2012 Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH. Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood. 120: 868-79. PMID 22613795 DOI: 10.1182/Blood-2012-03-414649  0.772
2012 Bushweller JH, Illendula A, Pulikkan JA, Grembecka J, Bradley P, Zhou Y, Xue L, Gao Y, Castilla LH. A Small Molecule Inhibitor of the CBFβ-SMMHC/RUNX Interaction Attenuates Inv(16) Leukemia in Vivo Blood. 120: 286-286. DOI: 10.1182/Blood.V120.21.286.286  0.505
2011 Landrette SF, Madera D, He F, Castilla LH. The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells. Leukemia. 25: 655-62. PMID 21263445 DOI: 10.1038/Leu.2010.301  0.808
2009 Kuo YH, Zaidi SK, Gornostaeva S, Komori T, Stein GS, Castilla LH. Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice. Blood. 113: 3323-32. PMID 19179305 DOI: 10.1182/Blood-2008-06-162248  0.754
2008 Castilla LH. C/EBPalpha in leukemogenesis: a matter of being in the right place with the right signals. Cancer Cell. 13: 289-91. PMID 18394549 DOI: 10.1016/J.Ccr.2008.03.009  0.48
2008 Kuo YH, Gerstein RM, Castilla LH. Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development. Blood. 111: 1543-51. PMID 17940206 DOI: 10.1182/Blood-2007-07-104422  0.695
2007 Zhao L, Cannons JL, Anderson S, Kirby M, Xu L, Castilla LH, Schwartzberg PL, Bosselut R, Liu PP. CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Blood. 109: 3432-40. PMID 17185462 DOI: 10.1182/Blood-2006-10-051508  0.476
2006 Heilman SA, Kuo YH, Goudswaard CS, Valk PJ, Castilla LH. Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice. Cancer Research. 66: 11214-8. PMID 17145866 DOI: 10.1158/0008-5472.Can-06-0959  0.76
2006 Gattelli A, Zimberlin MN, Meiss RP, Castilla LH, Kordon EC. Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines. Journal of Virology. 80: 11409-15. PMID 16971449 DOI: 10.1128/Jvi.00234-06  0.345
2006 Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, Le Beau MM, Kogan SC, Castilla LH. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell. 9: 57-68. PMID 16413472 DOI: 10.1016/J.Ccr.2005.12.014  0.799
2006 Zhao L, Cannons JL, Anderson S, Kirby MR, Xu L, Castilla L, Schwartzberg PL, Bosselut R, Liu PP. CBFB Is Required for Early T Cell Development in the Thymus. Blood. 108: 648-648. DOI: 10.1182/Blood.V108.11.648.648  0.476
2005 Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Blood. 105: 2900-7. PMID 15585652 DOI: 10.1182/Blood-2004-09-3630  0.805
2005 Landrette SF, Castilla LH. PLAGL2 Cooperates in Leukemia Development by Direcly Inducing c-Mpl Expression. Blood. 106: 744-744. DOI: 10.1182/Blood.V106.11.744.744  0.8
2004 Gattelli A, Cirio MC, Quaglino A, Schere-Levy C, Martinez N, Binaghi M, Meiss RP, Castilla LH, Kordon EC. Progression of pregnancy-dependent mouse mammary tumors after long dormancy periods. Involvement of Wnt pathway activation. Cancer Research. 64: 5193-9. PMID 15289324 DOI: 10.1158/0008-5472.Can-03-3992  0.619
2004 Castilla LH, Perrat P, Martinez NJ, Landrette SF, Keys R, Oikemus S, Flanegan J, Heilman S, Garrett L, Dutra A, Anderson S, Pihan GA, Wolff L, Liu PP. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 101: 4924-9. PMID 15044690 DOI: 10.1073/Pnas.0400930101  0.768
2004 Kuo Y, Heilman S, Chen A, Liu PP, Gernstein R, Kogan S, Castilla LH. Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice. Blood. 104: 543-543. DOI: 10.1182/Blood.V104.11.543.543  0.742
2004 Zhao L, Cannons JL, Castilla LH, Schwartzberg PL, Liu PP. The Role of CBFβ in T Cell Development. Blood. 104: 3234-3234. DOI: 10.1182/Blood.V104.11.3234.3234  0.486
2002 Kundu M, Chen A, Anderson S, Kirby M, Xu L, Castilla LH, Bodine D, Liu PP. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood. 100: 2449-56. PMID 12239155 DOI: 10.1182/Blood-2002-04-1064  0.499
2000 Adya N, Castilla LH, Liu PP. Function of CBFβ/Bro proteins Seminars in Cell & Developmental Biology. 11: 361-368. PMID 11105900 DOI: 10.1006/Scdb.2000.0189  0.412
1999 Castilla LH, Garrett L, Adya N, Orlic D, Dutra A, Anderson S, Owens J, Eckhaus M, Bodine D, Liu PP. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nature Genetics. 23: 144-6. PMID 10508507 DOI: 10.1038/13776  0.488
1997 Yamanaka R, Barlow C, Lekstrom-Himes J, Castilla LH, Liu PP, Eckhaus M, Decker T, Wynshaw-Boris A, Xanthopoulos KG. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 13187-13192. PMID 9371821 DOI: 10.1073/Pnas.94.24.13187  0.449
1996 Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M, Marín-Padilla M, Collins FS, Wynshaw-Boris A, Liu PP. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell. 87: 687-96. PMID 8929537 DOI: 10.1016/S0092-8674(00)81388-4  0.691
1996 Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, et al. Characterization of EZH1, a human homolog of Drosophila enhancer of zeste near BRCA1 Genomics. 37: 161-171. PMID 8921387 DOI: 10.1006/Geno.1996.0537  0.495
1995 Shattuck Eidens D, Mcclure M, Simard J, Labrie F, Narod S, Couch F, Hoskins K, Weber B, Castilla L, Erdos M, Brody L, Friedman L, Ostermeyer E, Szabo C, King MC, et al. A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene: Implications for Presymptomatic Testing and Screening Jama: the Journal of the American Medical Association. 273: 535-541. PMID 7837387 DOI: 10.1001/Jama.1995.03520310033026  0.322
1995 Couch FJ, Castilla LH, Xu J, Abel KJ, Welcsh P, King SE, Wong L, Ho PP, Merajver S, Brody LC, Yin G, Hayes ST, Gieser LM, Flejter WL, Glover TW, et al. A YAC-, P1-, and cosmid-based physical Map of the BRCA1 region on chromosome 17q21 Genomics. 25: 264-273. PMID 7774927 DOI: 10.1016/0888-7543(95)80134-8  0.463
1995 Brody LC, Abel KJ, Castilla LH, Couch FJ, McKinley DR, Yin G, Ho PP, Merajver S, Chandrasekharappa SC, Xu J, Cole JL, Struewing JP, Valdes JM, Collins FS, Weber BL. Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17 Genomics. 25: 238-247. PMID 7774924 DOI: 10.1016/0888-7543(95)80131-5  0.481
1995 Weber BL, Abel KJ, Couch FJ, Merajver S, Castilla L, Brody LC, Collins FS. Transcript identification in the BRCA1 candidate region Breast Cancer Research and Treatment. 33: 115-124. PMID 7749139 DOI: 10.1007/Bf00682719  0.517
1995 Couch FJ, Kiousis S, Castilla LH, Xu J, Chandrasekharappa SC, Chamberlain JS, Collins FS, Weber BL. Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21. Genomics. 24: 419-24. PMID 7713491 DOI: 10.1006/Geno.1994.1647  0.462
1995 Brody L, Castilla L, Struewing J, Erdos M, Collins FS. Mechanisms of familial breast cancer causation Cancer Genetics and Cytogenetics. 84: 129. DOI: 10.1016/0165-4608(96)85212-5  0.394
1994 Castilla LH, Couch FJ, Erdos MR, Hoskins KF, Calzone K, Garber JE, Boyd J, Lubin MB, Deshano ML, Brody LC, Collins FS, Weber BL. Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer Nature Genetics. 8: 387-391. PMID 7894491 DOI: 10.1038/Ng1294-387  0.485
1994 Weber BL, Abel KJ, Couch FJ, Merajver SD, Chandrasekharappa SC, Castilla L, McKinley D, Ho PP, Calzone K, Frank TS. Progress toward isolation of a breast cancer susceptibility gene, BRCA1. Cold Spring Harbor Symposia On Quantitative Biology. 59: 531-6. PMID 7587109 DOI: 10.1101/Sqb.1994.059.01.059  0.334
1993 Tagle DA, Blanchard-McQuate KL, Valdes J, Castilla L, MacDonald ME, Gusella JF, Collins FS. Dinucleotide repeat polymorphism in the Huntington's disease region at the D4S182 locus. Human Molecular Genetics. 2: 489. PMID 8504314 DOI: 10.1093/Hmg/2.4.489  0.383
1993 MacDonald ME, Ambrose CM, Duyao MP, Myers RH, Lin C, Srinidhi L, Barnes G, Taylor SA, James M, Groot N, MacFarlane H, Jenkins B, Anderson MA, Wexler NS, Gusella JF, ... ... Castilla L, et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell. 72: 971-983. PMID 8458085 DOI: 10.1016/0092-8674(93)90585-E  0.495
1993 Tagle DA, Blanchard-McQuate KL, Valdes J, Castilla L, Collins FS. Dinucleotide repeat polymorphisms at the D4S126 and D4S114 loci. Human Molecular Genetics. 2: 1077. PMID 8364551 DOI: 10.1093/Hmg/2.7.1077  0.391
1992 McCombie WR, Martin-Gallardo A, Gocayne JD, FitzGerald M, Dubnick M, Kelley JM, Castilla L, Liu LI, Wallace S, Trapp S, Tagle D, Whaley WL, Cheng S, Gusella J, Frischauf AM, et al. Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3 Nature Genetics. 1: 348-353. PMID 1338771 DOI: 10.1038/Ng0892-348  0.478
1990 Gilliam TC, Brzustowicz LM, Castilla LH, Lehner T, Penchaszadeh GK, Daniels RJ, Byth BC, Knowles J, Hislop JE, Shapira Y, Dubowitz V, Munsat TL, Ott J, Davies KE. Genetic homogeneity between acute and chronic forms of spinal muscular atrophy Nature. 345: 823-825. PMID 1972783 DOI: 10.1038/345823A0  0.358
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