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Shaomeng Wang - Publications

Affiliations: 
1986-1992 chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Molecular Therapeutics
Website:
http://sw16.im.med.umich.edu/
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319 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhao L, Han X, Lu J, McEachern D, Wang S. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia (New York, N.Y.). 22: 522-532. PMID 32928363 DOI: 10.1016/J.Neo.2020.07.002  0.301
2020 Barcherini V, Almeida J, Lopes E, Wang M, Silva D, Mori M, Wang S, Saraiva L, Santos MMM. Potency and selectivity optimization of tryptophanol-derived oxazoloisoindolinones: novel p53 activators in human colorectal cancer. Chemmedchem. PMID 32737944 DOI: 10.1002/Cmdc.202000522  0.384
2020 Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Fernandez-Salas E, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey J, ... ... Wang S, et al. EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. Journal of Medicinal Chemistry. PMID 32580550 DOI: 10.1021/Acs.Jmedchem.0C00479  0.396
2020 Chern TR, Liu L, Petrunak E, Stuckey JA, Wang M, Bernard D, Zhou H, Lee S, Dou Y, Wang S. Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Medicinal Chemistry Letters. 11: 1348-1352. PMID 32551023 DOI: 10.1021/Acsmedchemlett.0C00229  0.367
2020 Wang M, Lu J, Wang M, Yang CY, Wang S. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein. Journal of Medicinal Chemistry. PMID 32437146 DOI: 10.1021/Acs.Jmedchem.0C00471  0.379
2020 Xu S, Aguilar A, Huang L, Xu T, Zheng K, McEachern D, Przybranowski S, Foster C, Zawacki K, Liu Z, Chinnaswamy K, Stuckey J, Wang S. Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong Antitumor Activity. Journal of Medicinal Chemistry. PMID 32338903 DOI: 10.1021/Acs.Jmedchem.0C00547  0.355
2020 Zong D, Gu J, Cavalcante GC, Yao W, Zhang G, Wang S, Owonikoko TK, He X, Sun SY. BRD4 levels determine the response of human lung cancer cells to BET degraders that potently induce apoptosis through suppression of Mcl-1. Cancer Research. PMID 32156781 DOI: 10.1158/0008-5472.Can-19-3674  0.347
2020 Zhou H, Lu J, Yang CY, Sun Y, Wang S. Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway. Advances in Experimental Medicine and Biology. 1217: 349-362. PMID 31898237 DOI: 10.1007/978-981-15-1025-0_20  0.355
2020 Chen J, Wu C, Jiao L, Zhao L, Zhou Y, Li D, Tang G, Gu S, Deng J, Wang G, Fang DD, Wang S, Yang D, Zhai Y. Abstract 73: Development of APG-3526 as a novel and highly efficacious MCL-1 inhibitor Cancer Research. 80: 73-73. DOI: 10.1158/1538-7445.Am2020-73  0.421
2020 Kregel S, Wang C, Han X, Xiao L, Fernandez-Salas E, Bawa P, McCollum BL, Wilder-Romans K, Apel IJ, Cao X, Speers C, Wang S, Chinnaiyan AM. Abstract 5679: Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment Cancer Research. 80: 5679-5679. DOI: 10.1158/1538-7445.Am2020-5679  0.313
2020 Wang C, Rej RK, Lu J, Wang M, Harvey KP, Yang C, Fernandez-Salas E, Stuckey J, Petrunak E, Foster C, Zhou Y, Zhou R, Tang G, Chen J, Wang S. Abstract 1036: Discovery of a highly potent, efficacious and orally active small-molecule inhibitor of embryonic ectoderm development (EED) Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1036  0.317
2019 Han X, Zhao L, Xiang W, Qin C, Miao B, Xu T, Wang M, Yang CY, Chinnaswamy K, Stuckey J, Wang S. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. Journal of Medicinal Chemistry. PMID 31804827 DOI: 10.1021/Acs.Jmedchem.9B01393  0.337
2019 Zhou H, Bai L, Xu R, Zhao Y, Chen J, McEachern D, Chinnaswamy K, Wen B, Dai L, Kumar P, Yang CY, Liu Z, Wang M, Liu L, Meagher JL, ... ... Wang S, et al. Structure-Based Discovery of SD-36 as a Potent, Selective and Efficacious PROTAC Degrader of STAT3 Protein. Journal of Medicinal Chemistry. PMID 31747516 DOI: 10.1021/Acs.Jmedchem.9B01530  0.374
2019 Bai L, Zhou H, Xu R, Zhao Y, Chinnaswamy K, McEachern D, Chen J, Yang CY, Liu Z, Wang M, Liu L, Jiang H, Wen B, Kumar P, Meagher JL, ... ... Wang S, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 36: 498-511.e17. PMID 31715132 DOI: 10.1016/J.Ccell.2019.10.002  0.373
2019 Yang J, Li Y, Aguilar A, Liu Z, Yang CY, Wang S. Simple Structural Modifications Converting a Bona Fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. Journal of Medicinal Chemistry. PMID 31560543 DOI: 10.1021/Acs.Jmedchem.9B00846  0.365
2019 Aguilar A, Zheng K, Xu T, Xu S, Huang L, Fernandez-Salas E, Liu L, Bernard D, Harvey KP, Foster C, McEachern D, Stuckey J, Chinnaswamy K, Delproposto J, Kampf JW, ... Wang S, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. Journal of Medicinal Chemistry. PMID 31244110 DOI: 10.1021/Acs.Jmedchem.9B00021  0.377
2019 Yang CY, Qin C, Bai L, Wang S. Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins - A review. Drug Discovery Today. Technologies. 31: 43-51. PMID 31200858 DOI: 10.1016/J.Ddtec.2019.04.001  0.36
2019 Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, Qiao H, Li L, Yang J, Yu S, Zhao L, Wang S, Liu HM, Suo Z, Zhao W. Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction. Journal of Medicinal Chemistry. PMID 31157974 DOI: 10.1021/Acs.Jmedchem.9B00003  0.361
2019 Wang S, Dougan DA. The Direct Molecular Target for Imipridone ONC201 Is Finally Established. Cancer Cell. 35: 707-708. PMID 31085171 DOI: 10.1016/J.Ccell.2019.04.010  0.307
2019 Hu J, Hu B, Wang M, Xu F, Miao B, Yang CY, Wang M, Liu Z, Hayes DF, Chinnaswamy K, Delproposto J, Stuckey J, Wang S. Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). Journal of Medicinal Chemistry. 62: 1420-1442. PMID 30990042 DOI: 10.1021/Acs.Jmedchem.8B01572  0.305
2019 Wang S, Zhao L, Shi X, Ding L, Yang L, Wang ZZ, Shen D, Tang K, Li XJ, Mamun M, Li H, Yu B, Zheng YC, Wang S, Liu HM. The Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]Pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. Journal of Medicinal Chemistry. PMID 30803229 DOI: 10.1021/Acs.Jmedchem.9B00113  0.383
2019 Choi JE, Verhaegen ME, Yazdani S, Malik R, Harms PW, Mangelberger D, Tien J, Cao X, Wang Y, Cieślik M, Gurkan J, Yazdani M, Jing X, Juckette K, Su F, ... ... Wang S, et al. Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma. Neoplasia (New York, N.Y.). 21: 322-330. PMID 30797188 DOI: 10.1016/J.Neo.2019.01.003  0.345
2019 Shultis D, Mitra P, Huang X, Johnson J, Khattak NA, Gray F, Piper C, Czajka J, Hansen L, Wan B, Chinnaswamy K, Liu L, Wang M, Pan J, Stuckey J, ... ... Wang S, et al. Changing the Apoptosis Pathway through Evolutionary Protein Design. Journal of Molecular Biology. PMID 30625288 DOI: 10.1016/J.Jmb.2018.12.016  0.387
2019 Kregel S, Wang C, Fernandez-Salas E, Wilder-Romans K, Han X, Qin C, Xiang W, Tien J, Cao X, Speers C, Wang S, Chinnaiyan AM. Abstract 1001: Functional and mechanistic interrogation of androgen receptor degraders for the treatment of metastatic castration resistant prostate cancer Cancer Research. 79: 1001-1001. DOI: 10.1158/1538-7445.Am2019-1001  0.314
2018 Li Y, Yang J, Aguilar A, McEachern D, Przybranowski S, Liu L, Yang CY, Wang M, Han X, Wang S. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. Journal of Medicinal Chemistry. PMID 30525597 DOI: 10.1021/Acs.Jmedchem.8B00909  0.376
2018 Andrews A, Warner K, Rodriguez-Ramirez C, Pearson AT, Nör F, Zhang Z, Kerk S, Kulkarni A, Helman JI, Brenner JC, Wicha MS, Wang S, Nör JE. Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30498096 DOI: 10.1158/1078-0432.Ccr-17-2730  0.318
2018 Qin C, Hu Y, Zhou B, Fernandez-Salas E, Yang CY, Liu L, McEachern D, Przybranowski S, Wang M, Stuckey J, Meagher J, Bai L, Chen Z, Lin M, Yang J, ... ... Wang S, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. Journal of Medicinal Chemistry. PMID 30019901 DOI: 10.1021/Acs.Jmedchem.8B00506  0.386
2018 Zhao Y, Zhou B, Bai L, Liu L, Yang CY, Meagher JL, Stuckey JA, McEachern D, Przybranowski S, Wang M, Ran X, Aguilar A, Hu Y, Kampf JW, Li X, ... ... Wang S, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. Journal of Medicinal Chemistry. PMID 30015487 DOI: 10.1021/Acs.Jmedchem.8B00483  0.725
2018 Chen X, Liu L, Chen Y, Yang Y, Yang CY, Guo T, Lei M, Sun H, Wang S. Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction. Acs Medicinal Chemistry Letters. 9: 507-511. PMID 29795768 DOI: 10.1021/Acsmedchemlett.8B00152  0.313
2018 ZHou HB, Zhou W, Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang C, Li S, Wang M, Stuckey JA, Sun Y, Wang S. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. Journal of Medicinal Chemistry. PMID 29438612 DOI: 10.1021/Acs.Jmedchem.7B01455  0.415
2018 Deng J, Yin Y, Mao T, Zhai G, Yang D, Fang D, Wang S, Zhai Y, Yang D. Probing Distinct Oncogene Addiction By Novel BCL-2 Inhibitors Blood. 132: 2616-2616. DOI: 10.1182/Blood-2018-99-119816  0.323
2018 Wang G, Min P, Wu M, Dang S, Tang C, Zhang F, Guo M, Wang S, Deng J, Fang DD, Yang D, Zhai Y. Abstract 307: Targeting BCL-2 and BCL-xL with a novel dual inhibitor APG-1252 triggers cell death and inhibits tumor growth in small cell lung cancer models Cancer Research. 78: 307-307. DOI: 10.1158/1538-7445.Am2018-307  0.384
2018 Pan W, Fang DD, Wang G, Wu M, Li Y, Lian K, Cheng D, Kong Y, Zhai G, Guo M, Wang S, Yang D, Zhai Y. Abstract 1754: Smac mimetics APG-1387 synergizes with immune checkpoint inhibitors in preclinical models Cancer Research. 78: 1754-1754. DOI: 10.1158/1538-7445.Am2018-1754  0.353
2017 Toubai T, Rossi C, Oravecz-Wilson K, Liu C, Zajac C, Wu SJ, Sun Y, Fujiwara H, Tamaki H, Peltier D, Riwes M, Henig I, Brabbs S, Duckett CS, Wang S, et al. IAPs protect host target tissues from graft-versus-host disease in mice. Blood Advances. 1: 1517-1532. PMID 29296793 DOI: 10.1182/Bloodadvances.2017004242  0.306
2017 Wang S, Xu S, Aguilar A, Xu T, Zheng K, Huang L, Stuckey J, Chinnaswamy K, Bernard D, Fernández-Salas E, Liu L, Wang M, McEachern D, Przybranowski S, Foster C. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angewandte Chemie (International Ed. in English). PMID 29284071 DOI: 10.1002/Anie.201711828  0.358
2017 Zhou H, Lu J, Liu L, Bernard D, Yang CY, Fernandez-Salas E, Chinnaswamy K, Layton S, Stuckey J, Yu Q, Zhou W, Pan Z, Sun Y, Wang S. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nature Communications. 8: 1150. PMID 29074978 DOI: 10.1038/S41467-017-01243-7  0.378
2017 Karatas H, Li Y, Liu L, Ji J, Lee S, Chen Y, Yang J, Huang L, Bernard D, Xu J, Townsend EC, Cao F, Ran X, Li X, Wen B, ... ... Wang S, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. Journal of Medicinal Chemistry. PMID 28603984 DOI: 10.1021/Acs.Jmedchem.6B01796  0.801
2017 Zhao Y, Bai L, Liu L, McEachern D, Stuckey JA, Meagher JL, Yang CY, Ran X, Zhou B, Hu Y, Li X, Wen B, Zhao T, Li S, Sun D, ... Wang S, et al. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. Journal of Medicinal Chemistry. PMID 28463487 DOI: 10.1021/Acs.Jmedchem.7B00193  0.725
2017 Wang X, Qiao Y, Asangani IA, Ateeq B, Poliakov A, Cieślik M, Pitchiaya S, Chakravarthi BV, Cao X, Jing X, Wang CX, Apel IJ, Wang R, Tien JC, Juckette KM, ... ... Wang S, et al. Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer. Cancer Cell. PMID 28344039 DOI: 10.1016/J.Ccell.2017.02.017  0.329
2017 Aguilar A, Lu J, Liu L, Du D, Bernard D, McEachern D, Przybranowski S, Li X, Luo R, Wen B, Sun D, Wang H, Wen J, Wang G, Zhai Y, ... ... Wang S, et al. Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. Journal of Medicinal Chemistry. PMID 28339198 DOI: 10.1021/Acs.Jmedchem.6B01665  0.358
2017 Zhou B, Hu J, Xu F, Chen Z, Bai L, Fernandez-Salas E, Lin M, Liu L, Yang CY, Zhao Y, McEachern D, Przybranowski S, Wen B, Sun D, Wang S. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. Journal of Medicinal Chemistry. PMID 28339196 DOI: 10.1021/Acs.Jmedchem.6B01816  0.379
2017 Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. The Embo Journal. PMID 28320739 DOI: 10.15252/Embj.201694058  0.371
2017 Wang S, Zhao Y, Aguilar A, Bernard D, Yang CY. Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges. Cold Spring Harbor Perspectives in Medicine. PMID 28270530 DOI: 10.1101/Cshperspect.A026245  0.381
2017 Yang CY, Wang S. Allosteric Inactivation of Polycomb Repressive Complex 2 (PRC2) by Inhibiting Its Adapter Protein: Embryonic Ectodomain Development (EED). Journal of Medicinal Chemistry. PMID 28256832 DOI: 10.1021/Acs.Jmedchem.7B00287  0.361
2017 Bai L, Zhou B, Yang CY, Ji J, McEachern D, Przybranowski S, Jiang H, Hu J, Xu F, Zhao Y, Liu L, Fernandez-Salas E, Xu J, Dou Y, Wen B, ... ... Wang S, et al. Targeted degradation of BET proteins in triple-negative breast cancer. Cancer Research. PMID 28209615 DOI: 10.1158/0008-5472.Can-16-2622  0.391
2017 Liu-Chittenden Y, Jain M, Gaskins K, Wang S, Merino MJ, Kotian S, Kumar Gara S, Davis S, Zhang L, Kebebew E. RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma. Oncogene. PMID 28114280 DOI: 10.1038/Onc.2016.497  0.3
2017 Peterson LF, Lo MC, Liu Y, Gianolla D, Mitrikeska E, Donato NJ, Johnson CN, Wang S, Mercer J, Talpaz M. Induction of p53 suppresses chronic myeloid leukemia. Leukemia & Lymphoma. 1-14. PMID 28084835 DOI: 10.1080/10428194.2016.1272682  0.317
2017 Ray-Coquard I, Bourhis J, Delord J, Vuagniaux G, Zanna C, Lu B, Wang S. Debio-1143. Inhibitor of apoptosis protein (IAP) antagonist, Cancer therapy Drugs of the Future. 42: 745. DOI: 10.1358/Dof.2017.042.12.2702829  0.332
2017 Kregel S, Malik R, Asangani IA, Fernandez-Salas E, Wilder-Romans K, Jiang X, Rajendiran T, Cao X, Speers C, Wang S, Chinnaiyan AM. Abstract 5795: Functional and mechanistic interrogation of BET Bromodomain degraders for the treatment of metastatic castration resistant prostate cancer Cancer Research. 78: 5795-5795. DOI: 10.1158/1538-7445.Am2018-5795  0.331
2017 Bai L, Zhou B, Yang C, Ji J, McEachern D, Przybranowski S, Wang S. Abstract 5074: Therapeutic targeting of bromodomain and extra-terminal proteins degradation in triple-negative breast cancer Cancer Research. 77: 5074-5074. DOI: 10.1158/1538-7445.Am2017-5074  0.365
2016 Liu L, Lei I, Karatas H, Li Y, Wang L, Gnatovskiy L, Dou Y, Wang S, Qian L, Wang Z. Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts. Cell Discovery. 2: 16036. PMID 27924221 DOI: 10.1038/Celldisc.2016.36  0.653
2016 Lu J, McEachern D, Li S, Ellis MJ, Wang S. Reactivation of p53 by MDM2 inhibitor MI-77301 for the treatment of endocrine-resistant breast cancer. Molecular Cancer Therapeutics. PMID 27765850 DOI: 10.1158/1535-7163.Mct-16-0028  0.332
2016 Wang B, Peng Y, Guo Y, Yuan Y, Zhao M, Wang S. Impact of partial nitritation degree and C/N ratio on simultaneous Sludge Fermentation, Denitrification and Anammox process. Bioresource Technology. 219: 411-419. PMID 27513647 DOI: 10.1016/j.biortech.2016.07.114  0.373
2016 Ablikim M, Achasov MN, Ahmed S, Ai XC, Albayrak O, Albrecht M, Ambrose DJ, Amoroso A, An FF, An Q, Bai JZ, Baldini Ferroli R, Ban Y, Bennett DW, Bennett JV, ... Wang SG, et al. Observation of an Anomalous Line Shape of the η^{'}π^{+}π^{-} Mass Spectrum near the pp[over ¯] Mass Threshold in J/ψ→γη^{'}π^{+}π^{-}. Physical Review Letters. 117: 042002. PMID 27494467 DOI: 10.1103/Physrevlett.117.042002  0.339
2016 Zhao Y, Chu X, Chen J, Wang Y, Gao S, Jiang Y, Zhu X, Tan G, Zhao W, Yi H, Xu H, Ma X, Lu Y, Yi Q, Wang S. Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells. Nature Communications. 7: 12368. PMID 27492902 DOI: 10.1038/ncomms12368  0.392
2016 Wu S, Tan J, Yang Y, Peng Q, Zhang M, Li J, Lu D, Liu Y, Lou H, Feng Q, Lu Y, Guan Y, Zhang Z, Jiao Y, Sabeti P, ... ... Wang S, et al. Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Human Genetics. PMID 27487801 DOI: 10.1007/S00439-016-1718-Y  0.36
2016 Li CL, Li KC, Wu D, Chen Y, Luo H, Zhao JR, Wang SS, Sun MM, Lu YJ, Zhong YQ, Hu XY, Hou R, Zhou BB, Bao L, Xiao HS, et al. Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Research. 26: 967. PMID 27481604 DOI: 10.1038/cr.2016.90  0.351
2016 Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Asilar E, Bergauer T, Brandstetter J, Brondolin E, Dragicevic M, Erö J, Flechl M, Friedl M, Frühwirth R, Ghete VM, Hartl C, ... Wang S, et al. Search for Narrow Resonances in Dijet Final States at sqrt[s]=8  TeV with the Novel CMS Technique of Data Scouting. Physical Review Letters. 117: 031802. PMID 27472109 DOI: 10.1103/PhysRevLett.117.031802  0.348
2016 Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Asilar E, Bergauer T, Brandstetter J, Brondolin E, Dragicevic M, Erö J, Friedl M, Frühwirth R, Ghete VM, Hartl C, Hörmann N, ... Wang S, et al. Event generator tunes obtained from underlying event and multiparton scattering measurements. The European Physical Journal. C, Particles and Fields. 76: 155. PMID 27471433 DOI: 10.1140/Epjc/S10052-016-3988-X  0.351
2016 Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Asilar E, Bergauer T, Brandstetter J, Brondolin E, Dragicevic M, Erö J, Friedl M, Frühwirth R, Ghete VM, Hartl C, Hörmann N, ... Wang S, et al. Measurement of the [Formula: see text] production cross section in the all-jets final state in pp collisions at [Formula: see text][Formula: see text]. The European Physical Journal. C, Particles and Fields. 76: 128. PMID 27471431 DOI: 10.1140/Epjc/S10052-016-3956-5  0.333
2016 Chen X, Gui X, Zhang L, Huang F, Zhong H, Pang Z, Wang S, Tang L, Fu L, Peng Y, Shellman Y. Maternal anti-HBVs suppress the immune response of infants to hepatitis B vaccine. Journal of Viral Hepatitis. PMID 27469237 DOI: 10.1111/Jvh.12572  0.353
2016 Xu J, Li L, Xiong J, denDekker A, Ye A, Karatas H, Liu L, Wang H, Qin ZS, Wang S, Dou Y. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program. Cell Discovery. 2: 16008. PMID 27462455 DOI: 10.1038/Celldisc.2016.8  0.668
2016 Wang C, Yin MX, Wu W, Dong L, Wang S, Lu Y, Xu J, Wu W, Li S, Zhao Y, Zhang L. Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration. Cell Discovery. 2: 16006. PMID 27462453 DOI: 10.1038/celldisc.2016.6  0.412
2016 Wang S, Lu Y, Sun X, Wu D, Fu B, Chen Y, Deng H, Chen X. Identification of common and differential mechanisms of glomerulus and tubule senescence in 24-month-old rats by quantitative LC-MS/MS. Proteomics. PMID 27452873 DOI: 10.1002/pmic.201600121  0.358
2016 Wang S, Shi X, Li H, Pang P, Pei L, Shen H, Lu Y. DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies. Molecular Neurobiology. PMID 27447806 DOI: 10.1007/S12035-016-0008-Y  0.394
2016 Miao Y, Zhang L, Yang Y, Peng Y, Li B, Wang S, Zhang Q. Start-up of single-stage partial nitrification-anammox process treating low-strength swage and its restoration from nitrate accumulation. Bioresource Technology. 218: 771-779. PMID 27423544 DOI: 10.1016/J.Biortech.2016.06.125  0.379
2016 Peng Y, Wang S, Li R, Li H, Cheng H, Chen M, Liu S. Luminous efficacy enhancement of ultraviolet-excited white light-emitting diodes through multilayered phosphor-in-glass. Applied Optics. 55: 4933-4938. PMID 27409121  0.375
2016 Ablikim M, Achasov MN, Ai XC, Albayrak O, Albrecht M, Ambrose DJ, Amoroso A, An FF, An Q, Bai JZ, Baldini Ferroli R, Ban Y, Bennett DW, Bennett JV, Bertani M, ... Wang SG, et al. Observation of h_{c} Radiative Decay h_{c}→γη^{'} and Evidence for h_{c}→γη. Physical Review Letters. 116: 251802. PMID 27391715 DOI: 10.1103/Physrevlett.116.251802  0.341
2016 Lu YM, Zeng JF, Wang S, Sun BA, Wang Q, Lu J, Gravier S, Bladin JJ, Wang WH, Pan MX, Liu CT, Yang Y. Structural Signature of Plasticity Unveiled by Nano-Scale Viscoelastic Contact in a Metallic Glass. Scientific Reports. 6: 29357. PMID 27383387 DOI: 10.1038/Srep29357  0.349
2016 Tao L, Wang S, Zhao Y, Wang AY, Zhang L, Ruan JS, Fan FT, Liu YP, Li Y, Yue ZQ, Qian WH, Chen WX, Lu Y. Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis. Chinese Journal of Integrative Medicine. PMID 27358204 DOI: 10.1007/s11655-015-2405-x  0.386
2016 Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, ... ... Wang SR, et al. Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Plos Genetics. 12: e1006166. PMID 27355579 DOI: 10.1371/Journal.Pgen.1006166  0.341
2016 Sadinski M, Karczmar G, Peng Y, Wang S, Jiang Y, Medved M, Yousuf A, Antic T, Oto A. Pilot Study of the Use of Hybrid Multidimensional T2-Weighted Imaging-DWI for the Diagnosis of Prostate Cancer and Evaluation of Gleason Score. Ajr. American Journal of Roentgenology. 1-7. PMID 27352026 DOI: 10.2214/Ajr.15.15626  0.384
2016 Ma H, Xu X, Clague J, Lu Y, Togawa K, Wang SS, Clarke CA, Lee E, Park HL, Sullivan-Halley J, Neuhausen SL, Bernstein L. Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study. Breast Cancer Research : Bcr. 18: 62. PMID 27317095 DOI: 10.1186/S13058-016-0723-3  0.363
2016 Wang Y, Wang SS, Lu Y, Jiang JZ, Yang SA. Strain-induced Isostructural and Magnetic Phase Transitions in Monolayer MoN2. Nano Letters. PMID 27310459 DOI: 10.1021/Acs.Nanolett.6B01841  0.351
2016 Li D, Wang S, Ye H, Tang Y, Qiu X, Fan Q, Rong X, Liu X, Chen Y, Yang J, Lu Y. Distribution of gene mutations in sporadic congenital cataract in a Han Chinese population. Molecular Vision. 22: 589-98. PMID 27307692  0.335
2016 Tan CM, Li CH, Tsao NW, Su LW, Lu YT, Chang SH, Lin YY, Liou JC, Hsieh LC, Yu JZ, Sheue CR, Wang SY, Lee CF, Yang JY. Phytoplasma SAP11 alters 3-isobutyl-2-methoxypyrazine biosynthesis in Nicotiana benthamiana by suppressing NbOMT1. Journal of Experimental Botany. PMID 27279277 DOI: 10.1093/jxb/erw225  0.384
2016 Wang S, Yang B, Yang Q, Lu L, Wang X, Peng Y. Temporal Trends and Spatial Variability of Vegetation Phenology over the Northern Hemisphere during 1982-2012. Plos One. 11: e0157134. PMID 27276082 DOI: 10.1371/journal.pone.0157134  0.359
2016 Miao L, Wang S, Li B, Cao T, Zhang F, Wang Z, Peng Y. Effect of carbon source type on intracellular stored polymers during endogenous denitritation (ED) treating landfill leachate. Water Research. 100: 405-412. PMID 27232984 DOI: 10.1016/J.Watres.2016.05.010  0.371
2016 Lin IM, Wang SY, Chu IH, Lu YH, Lee CS, Lin TH, Fan SY. The Association of Type D personality with Heart Rate Variability and Lipid Profiles Among Patients with Coronary Artery Disease. International Journal of Behavioral Medicine. PMID 27229521 DOI: 10.1007/s12529-016-9571-x  0.344
2016 Wang SN, Peng Y, Lu ZY, Dhiloo KH, Zheng Y, Shan S, Li RJ, Zhang YJ, Guo YY. Cloning and expression of ionotropic receptors in the parasitoid wasp Micropilitis mediator (Hymenoptera: Braconidae). Journal of Insect Physiology. PMID 27208597 DOI: 10.1016/j.jinsphys.2016.05.002  0.383
2016 Wang S, Ouyang B, Aa J, Geng J, Fei F, Wang P, Wang J, Peng Y, Geng T, Li Y, Huang W, Wang Z, Xiao W, Wang G. Pharmacokinetics and tissue distribution of ginkgolide A, ginkgolide B, and ginkgolide K after intravenous infusion of ginkgo diterpene lactones in a rat model. Journal of Pharmaceutical and Biomedical Analysis. 126: 109-116. PMID 27182682 DOI: 10.1016/j.jpba.2016.04.035  0.39
2016 Wang Z, Peng Y, Miao L, Cao T, Zhang F, Wang S, Han J. Continuous-flow combined process of nitritation and ANAMMOX for treatment of landfill leachate. Bioresource Technology. 214: 514-519. PMID 27176671 DOI: 10.1016/j.biortech.2016.04.118  0.387
2016 Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Asilar E, Bergauer T, Brandstetter J, Brondolin E, Dragicevic M, Erö J, Flechl M, Friedl M, Frühwirth R, Ghete VM, Hartl C, ... Wang S, et al. Measurement of Long-Range Near-Side Two-Particle Angular Correlations in pp Collisions at sqrt[s]=13  TeV. Physical Review Letters. 116: 172302. PMID 27176516 DOI: 10.1103/Physrevlett.116.172302  0.342
2016 Jin B, Wang S, Xing L, Li B, Peng Y. The effect of salinity on waste activated sludge alkaline fermentation and kinetic analysis. Journal of Environmental Sciences (China). 43: 80-90. PMID 27155412 DOI: 10.1016/J.Jes.2015.10.011  0.406
2016 Zhang YN, Zhao HJ, Wang Y, Lu Y, Wang SJ. [Effect of Electroacupuncture Intervention on Constipation-predominant Irritable Bow l Syndrome and Colonic CGRP and SP Expression in Rats]. Zhen Ci Yan Jiu = Acupuncture Research / [Zhongguo Yi Xue Ke Xue Yuan Yi Xue Qing Bao Yan Jiu Suo Bian Ji]. 41: 31-4. PMID 27141617  0.356
2016 Wang B, Peng Y, Guo Y, Zhao M, Wang S. Nitrogen removal from wastewater and external waste activated sludge reutilization/reduction by simultaneous sludge fermentation, denitrification and anammox (SFDA). Bioresource Technology. 214: 284-291. PMID 27140818 DOI: 10.1016/j.biortech.2016.04.075  0.374
2016 Zhang M, Yang Q, Zhang J, Wang C, Wang S, Peng Y. Enhancement of denitrifying phosphorus removal and microbial community of long-term operation in an anaerobic anoxic oxic-biological contact oxidation system. Journal of Bioscience and Bioengineering. PMID 27133708 DOI: 10.1016/j.jbiosc.2016.03.019  0.38
2016 Hu H, Lu Y, Cui L, Zhang J, Zhao Z, Qin B, Wang Y, Wang Q, Wang S. Impact of previous open renal surgery on the outcomes of subsequent percutaneous nephrolithotomy: a meta-analysis. Bmj Open. 6: e010627. PMID 27126976 DOI: 10.1136/bmjopen-2015-010627  0.325
2016 Yu A, Duan H, Zhang T, Pan Y, Kou Z, Zhang X, Lu Y, Wang S, Yang Z. IL-17A promotes microglial activation and neuroinflammation in mouse models of intracerebral haemorrhage. Molecular Immunology. 73: 151-157. PMID 27107665 DOI: 10.1016/j.molimm.2016.04.003  0.345
2016 Xie T, Zhou X, Wang S, Lu Y, Zhu H, Kang A, Deng H, Xu J, Shen C, Di L, Shan J. Development and application of a comprehensive lipidomic analysis to investigate Tripterygium wilfordii-induced liver injury. Analytical and Bioanalytical Chemistry. PMID 27086014 DOI: 10.1007/s00216-016-9533-9  0.349
2016 Lu Y, Xia Y, Liu G, Pan M, Li M, Lee NA, Wang S. A review of methods for detecting melamine in food samples. Critical Reviews in Analytical Chemistry / Crc. 0. PMID 27077504 DOI: 10.1080/10408347.2016.1176889  0.35
2016 Fei F, Yang H, Peng Y, Wang P, Wang S, Zhao Y, Huang J, Yu X, Feng S, Sun R, Yang N, Wang H, Aa J, Wang G. Sensitive analysis and pharmacokinetic study of the isomers paeoniflorin and albiflorin after oral administration of Total Glucosides Of White Paeony Capsule in rats. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1022: 30-37. PMID 27070118 DOI: 10.1016/j.jchromb.2016.04.005  0.382
2016 Lu Y, Qin B, Hu H, Zhang J, Wang Y, Wang Q, Wang S. Integrative microRNA-gene expression network analysis in genetic hypercalciuric stone-forming rat kidney. Peerj. 4: e1884. PMID 27069814 DOI: 10.7717/peerj.1884  0.343
2016 Yuan Y, Liu Y, Li B, Wang B, Wang S, Peng Y. Short-chain fatty acids production and microbial community in sludge alkaline fermentation: Long-term effect of temperature. Bioresource Technology. 211: 685-690. PMID 27060243 DOI: 10.1016/J.Biortech.2016.03.138  0.386
2016 Wang X, Wang S, Zhao J, Dai X, Li B, Peng Y. A novel stoichiometries methodology to quantify functional microorganisms in simultaneous (partial) nitrification-endogenous denitrification and phosphorus removal (SNEDPR). Water Research. 95: 319-329. PMID 27016642 DOI: 10.1016/J.Watres.2015.12.046  0.394
2016 Zhang H, Gayen S, Xiong J, Zhou B, Shanmugam AK, Sun Y, Karatas H, Liu L, Rao RC, Wang S, Nesvizhskii AI, Kalantry S, Dou Y. MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency. Cell Stem Cell. PMID 26996599 DOI: 10.1016/J.Stem.2016.02.004  0.63
2016 Bai L, Zhao Y, Liu L, Yang C, McEachern D, Stuckey J, Meagher J, Wen B, Sun D, Wang S. Abstract 1250: Antitumor activities of CD161, a structurally novel and orally bioavailable BET inhibitor, in leukemia and triple negative breast cancer cellsin vitroandin vivo Cancer Research. 76: 1250-1250. DOI: 10.1158/1538-7445.Am2016-1250  0.349
2015 Liu H, Wang S, Ma W, Lu Y. Transforming Growth Factor β1 Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells Via Up-Regulation of Connective Tissue Growth Factor. Cell Biochemistry and Biophysics. 73: 775-81. PMID 27259324 DOI: 10.1007/s12013-015-0693-6  0.365
2015 Ran X, Liu L, Yang C, Lu J, Chen Y, Lei M, Wang S. Design of High-affinity Stapled Peptides to Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex. Journal of Medicinal Chemistry. PMID 26673461 DOI: 10.1021/Acs.Jmedchem.5B01465  0.715
2015 Langdon CG, Wiedemann N, Held MA, Mamillapalli R, Iyidogan P, Theodosakis N, Platt JT, Levy F, Vuagniaux G, Wang S, Bosenberg MW, Stern DF. SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells. Oncotarget. PMID 26485762 DOI: 10.18632/Oncotarget.6138  0.36
2015 Ashley SL, Sisson TH, Wheaton AK, Kim KK, Wilke CA, Ajayi IO, Subbotina N, Wang S, Duckett CS, Moore BB, Horowitz JC. Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-induced Lung Fibrosis. American Journal of Respiratory Cell and Molecular Biology. PMID 26378893 DOI: 10.1165/Rcmb.2015-0148Oc  0.308
2015 Acasigua GA, Warner KA, Nör F, Helman J, Pearson AT, Fossati AC, Wang S, Nör JE. BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncology. PMID 26121939 DOI: 10.1016/J.Oraloncology.2015.06.004  0.313
2015 Ran X, Zhao Y, Liu L, Bai L, Yang CY, Zhou B, Meagher JL, Chinnaswamy K, Stuckey JA, Wang S. Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. Journal of Medicinal Chemistry. 58: 4927-39. PMID 26080064 DOI: 10.1021/Acs.Jmedchem.5B00613  0.738
2015 Hoffman-Luca CG, Yang CY, Lu J, Ziazadeh D, McEachern D, Debussche L, Wang S. Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment. Plos One. 10: e0128807. PMID 26070072 DOI: 10.1371/Journal.Pone.0128807  0.33
2015 Liu L, Bernard D, Wang S. Case Study: discovery of inhibitors of the MDM2-p53 protein-protein interaction. Methods in Molecular Biology (Clifton, N.J.). 1278: 567-85. PMID 25859977 DOI: 10.1007/978-1-4939-2425-7_38  0.349
2015 Sun Y, Wang Y, Toubai T, Oravecz-Wilson K, Liu C, Mathewson N, Wu J, Rossi C, Cummings E, Wu D, Wang S, Reddy P. BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice. Blood. 125: 2724-8. PMID 25778533 DOI: 10.1182/Blood-2014-08-598037  0.309
2015 Zhao Y, Aguilar A, Bernard D, Wang S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment. Journal of Medicinal Chemistry. 58: 1038-52. PMID 25396320 DOI: 10.1021/Jm501092Z  0.371
2015 Langdon CG, Wiedemann N, Held MA, Platt JT, Mamillapalli R, Iyidogan P, Theodosakis N, Levy F, Robichon D, Zanna C, Vuagniaux G, Sorensen M, Wang S, Bosenberg MW, Stern DF. Abstract 2529: Debio 1143 synergizes with taxanes, topoisomerase and bromodomain inhibitors to inhibit growth of lung adenocarcinoma Cancer Research. 75: 2529-2529. DOI: 10.1158/1538-7445.Am2015-2529  0.374
2015 Karatas H, Lee SY, Townsend EC, Cao F, Xu J, Bernard D, Liu L, Dou Y, Wang S. Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein-protein interaction as inhibitors of the MLL1 methyltransferase activity Chinese Chemical Letters. 26: 455-458. DOI: 10.1016/J.Cclet.2015.03.030  0.689
2014 Aguilar A, Sun W, Liu L, Lu J, McEachern D, Bernard D, Deschamps JR, Wang S. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles. Journal of Medicinal Chemistry. 57: 10486-98. PMID 25496041 DOI: 10.1021/Jm501541J  0.371
2014 Wang S, Sun W, Zhao Y, McEachern D, Meaux I, Barrière C, Stuckey JA, Meagher JL, Bai L, Liu L, Hoffman-Luca CG, Lu J, Shangary S, Yu S, Bernard D, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Research. 74: 5855-65. PMID 25145672 DOI: 10.1158/0008-5472.Can-14-0799  0.35
2014 Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, Wang S. BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. Plos One. 9: e99404. PMID 24901320 DOI: 10.1371/Journal.Pone.0099404  0.396
2014 Bai L, Smith DC, Wang S. Small-molecule SMAC mimetics as new cancer therapeutics. Pharmacology & Therapeutics. 144: 82-95. PMID 24841289 DOI: 10.1016/J.Pharmthera.2014.05.007  0.362
2014 Asangani IA, Dommeti VL, Wang X, Malik R, Cieslik M, Yang R, Escara-Wilke J, Wilder-Romans K, Dhanireddy S, Engelke C, Iyer MK, Jing X, Wu YM, Cao X, Qin ZS, ... Wang S, et al. Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer. Nature. 510: 278-82. PMID 24759320 DOI: 10.1038/Nature13229  0.316
2014 Sun H, Lu J, Liu L, Yang CY, Wang S. Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells. Acs Chemical Biology. 9: 994-1002. PMID 24521431 DOI: 10.1021/Cb400889A  0.374
2014 Cao F, Townsend EC, Karatas H, Xu J, Li L, Lee S, Liu L, Chen Y, Ouillette P, Zhu J, Hess JL, Atadja P, Lei M, Qin ZS, Malek S, ... Wang S, et al. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Molecular Cell. 53: 247-61. PMID 24389101 DOI: 10.1016/J.Molcel.2013.12.001  0.669
2014 Bai L, Wang S. Targeting apoptosis pathways for new cancer therapeutics. Annual Review of Medicine. 65: 139-55. PMID 24188661 DOI: 10.1146/Annurev-Med-010713-141310  0.368
2014 Langdon CG, Wiedemann N, Held MA, Platt JT, Lévy F, Robichon D, Zanna C, Vuagniaux G, Sorensen M, Wang S, Bosenberg MW, Stern DF. Abstract 5441: Debio 1143, an oral antagonist of the inhibitor of apoptosis proteins, synergistically enhances the effects of multiple standard of care agents in human lung cancer models Cancer Research. 74: 5441-5441. DOI: 10.1158/1538-7445.Am2014-5441  0.342
2014 Bai L, Chen J, Liu L, McEachern D, Aguilar A, Zhou H, Yang CY, Wang H, Wen J, Wang G, Zhai Y, Guo M, Yang D, Wang S. 338 BM-1252 (APG-1252): a potent dual specific Bcl-2/Bcl-xL inhibitor that achieves complete tumor regression with minimal platelet toxicity European Journal of Cancer. 50: 109-110. DOI: 10.1016/S0959-8049(14)70464-2  0.321
2013 Zhao Y, Yang CY, Wang S. The making of I-BET762, a BET bromodomain inhibitor now in clinical development. Journal of Medicinal Chemistry. 56: 7498-500. PMID 24107192 DOI: 10.1021/Jm4014407  0.341
2013 Zhang T, Li Y, Zou P, Yu JY, McEachern D, Wang S, Sun D. Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer. Biopharmaceutics & Drug Disposition. 34: 348-59. PMID 23813446 DOI: 10.1002/Bdd.1850  0.312
2013 Zhao Y, Yu S, Sun W, Liu L, Lu J, McEachern D, Shargary S, Bernard D, Li X, Zhao T, Zou P, Sun D, Wang S. A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. Journal of Medicinal Chemistry. 56: 5553-61. PMID 23786219 DOI: 10.1021/Jm4005708  0.377
2013 Long J, Liu L, Nikolovska-Coleska Z, Shangary S, Yi H, Wang S, Wang S. Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins. Bmc Biotechnology. 13: 45. PMID 23705845 DOI: 10.1186/1472-6750-13-45  0.342
2013 Kurokawa M, Kim J, Geradts J, Matsuura K, Liu L, Ran X, Xia W, Ribar TJ, Henao R, Dewhirst MW, Kim WJ, Lucas JE, Wang S, Spector NL, Kornbluth S. A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Science Signaling. 6: ra32. PMID 23652204 DOI: 10.1126/Scisignal.2003741  0.703
2013 Sheng R, Sun H, Liu L, Lu J, McEachern D, Wang G, Wen J, Min P, Du Z, Lu H, Kang S, Guo M, Yang D, Wang S. A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. Journal of Medicinal Chemistry. 56: 3969-79. PMID 23651223 DOI: 10.1021/Jm400216D  0.362
2013 Zhao Y, Liu L, Sun W, Lu J, McEachern D, Li X, Yu S, Bernard D, Ochsenbein P, Ferey V, Carry JC, Deschamps JR, Sun D, Wang S. Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors. Journal of the American Chemical Society. 135: 7223-34. PMID 23641733 DOI: 10.1021/Ja3125417  0.412
2013 Aguilar A, Zhou H, Chen J, Liu L, Bai L, McEachern D, Yang CY, Meagher J, Stuckey J, Wang S. A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. Journal of Medicinal Chemistry. 56: 3048-67. PMID 23448298 DOI: 10.1021/Jm4001105  0.403
2013 Zhou H, Liu L, Huang J, Bernard D, Karatas H, Navarro A, Lei M, Wang S. Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction. Journal of Medicinal Chemistry. 56: 1113-23. PMID 23244744 DOI: 10.1021/Jm3015298  0.696
2013 Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. Journal of the American Chemical Society. 135: 669-82. PMID 23210835 DOI: 10.1021/Ja306028Q  0.703
2013 Ellis MJ, Li S, Shen D, Ding L, Crowder R, Shao J, Goncalves R, Tao Y, Luo J, Prat A, Liu W, Gonzalez-Angulo AM, Liu S, McMichael JF, Miller C, ... ... Wang S, et al. Abstract LB-265: Patient-derived xenografts from advanced luminal-type breast cancer: insights into endocrine therapy resistance. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-265  0.302
2013 Hoffman-Luca CG, McEachern D, Ziazadeh D, Zhao Y, Sun W, Debussche L, Wang S. Abstract C250: Concurrent targeting Bcl-2/Bcl-xL and MDM2 as a new therapeutic strategy for acute leukemia. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C250  0.318
2013 Langdon CG, Wiedemann N, Held MA, Platt JT, Lévy F, Zanna C, Vuagniaux G, Sorensen M, Wang S, Bosenberg MW, Stern DF. Abstract A16: A drug combination screen identifies taxanes as synergistic agents with the oral IAP inhibitor Debio 1143 in non-small cell lung cancer cells. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A16  0.348
2012 Yang CY, Wang S. Analysis of Flexibility and Hotspots in Bcl-xL and Mcl-1 Proteins for the Design of Selective Small-Molecule Inhibitors. Acs Medicinal Chemistry Letters. 3: 308-12. PMID 24900469 DOI: 10.1021/Ml200301W  0.357
2012 Wang S, Bai L, Lu J, Liu L, Yang CY, Sun H. Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. Journal of Mammary Gland Biology and Neoplasia. 17: 217-28. PMID 23054134 DOI: 10.1007/S10911-012-9265-1  0.353
2012 Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. Journal of Medicinal Chemistry. 55: 8502-14. PMID 23030453 DOI: 10.1021/Jm3010306  0.412
2012 Zhou H, Aguilar A, Chen J, Bai L, Liu L, Meagher JL, Yang CY, McEachern D, Cong X, Stuckey JA, Wang S. Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity. Journal of Medicinal Chemistry. 55: 6149-61. PMID 22747598 DOI: 10.1021/Jm300608W  0.411
2012 Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Correction to Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. Journal of Medicinal Chemistry. 55: 5987. PMID 22676037 DOI: 10.1021/Jm300728G  0.354
2012 Brunckhorst MK, Lerner D, Wang S, Yu Q. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer Biology & Therapy. 13: 804-11. PMID 22669575 DOI: 10.4161/Cbt.20563  0.356
2012 Bernard D, Zhao Y, Wang S. AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development. Journal of Medicinal Chemistry. 55: 4934-5. PMID 22624960 DOI: 10.1021/Jm3007068  0.346
2012 McComb S, Cheung HH, Korneluk RG, Wang S, Krishnan L, Sad S. cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death and Differentiation. 19: 1791-801. PMID 22576661 DOI: 10.1038/Cdd.2012.59  0.324
2012 Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. Journal of Medicinal Chemistry. 55: 4664-82. PMID 22448988 DOI: 10.1021/Jm300178U  0.411
2012 Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S. LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling. Cancer Research. 72: 1229-38. PMID 22241084 DOI: 10.1158/0008-5472.Can-11-2428  0.351
2012 Kawamoto SA, Coleska A, Ran X, Yi H, Yang CY, Wang S. Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction. Journal of Medicinal Chemistry. 55: 1137-46. PMID 22196480 DOI: 10.1021/Jm201125D  0.769
2012 Peng Y, Sun H, Lu J, Liu L, Cai Q, Shen R, Yang CY, Yi H, Wang S. Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. Journal of Medicinal Chemistry. 55: 106-14. PMID 22148838 DOI: 10.1021/Jm201072X  0.576
2012 Yang D, Zhao Y, Li AY, Wang S, Wang G, Sun Y. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast Cancer Research and Treatment. 133: 189-99. PMID 21901386 DOI: 10.1007/S10549-011-1752-3  0.341
2012 Verhaegen M, Checinska A, Riblett MB, Wang S, Soengas MS. E2F1-dependent oncogenic addiction of melanoma cells to MDM2 Oncogene. 31: 828-841. PMID 21743494 DOI: 10.1038/Onc.2011.277  0.334
2012 Townsend EC, Cao F, Karatas H, Wang S, Dou Y. Abstract LB-256: Targeting MLL1 methyltransferase activity for treatment of acute leukemia with MLL1 rearrangement Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-256  0.683
2012 Meaux I, Barrière C, McEachern D, Guerif S, Besret L, Dos-Santos O, D'Agostino S, Sanchez I, Gorge-Bernat D, Pannier P, Ratet N, Watters J, Miao H, Sager J, Lengauer C, ... ... Wang S, et al. Abstract 4731: Cytotoxic versus cytostatic effects in tumor models by spiro-oxindole-based modulators of the MDM2-p53 interaction Cancer Research. 72: 4731-4731. DOI: 10.1158/1538-7445.Am2012-4731  0.357
2012 Delaisi C, Meaux I, Dos-Santos O, Barrière C, Duffieux F, Hoffmann D, Rak A, Wolfrom M, Flèche F, Zhou-Liu Q, Lalleman V, Bégassat F, Lowinski M, Besnard S, Chalain DD, ... ... Wang S, et al. Abstract 4648: In vitro characterization of spiro-oxindole-based modulators of the MDM2-p53 interaction and their interspecies selectivity. Cancer Research. 72: 4648-4648. DOI: 10.1158/1538-7445.Am2012-4648  0.359
2012 Zhang Y, Remillard SP, Demetri GD, Wang S, Debussche L, Wagner AJ. Abstract 2786: Potent inhibition of human liposarcoma cell growth and survival by novel modulators of the MDM2-p53 interaction Cancer Research. 72: 2786-2786. DOI: 10.1158/1538-7445.Am2012-2786  0.378
2012 Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, Yang CY, Meagher JL, Stuckey JA, Wang S. 412 Antitumor Activity of BM-1197, a Dual Inhibitor of Bcl-2 and Bcl-xL, in Small Cell Lung Cancer Tumors European Journal of Cancer. 48: 125. DOI: 10.1016/S0959-8049(12)72210-4  0.317
2011 Yang CY, Wang S. Hydrophobic Binding Hot Spots of Bcl-xL Protein-Protein Interfaces by Cosolvent Molecular Dynamics Simulation. Acs Medicinal Chemistry Letters. 2: 280-4. PMID 24900309 DOI: 10.1021/Ml100276B  0.344
2011 Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. Journal of Medicinal Chemistry. 54: 3306-18. PMID 21462933 DOI: 10.1021/Jm101651B  0.421
2011 Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang CY, Miller R, Yi H, Zhang T, Sun D, Kang S, Guo M, ... ... Wang S, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. Journal of Medicinal Chemistry. 54: 2714-26. PMID 21443232 DOI: 10.1021/Jm101505D  0.578
2011 Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S. Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment. Molecular Cancer Therapeutics. 10: 902-14. PMID 21372226 DOI: 10.1158/1535-7163.Mct-10-0864  0.55
2011 Peterson LF, Mitrikeska E, Giannola D, Lui Y, Sun H, Bixby D, Malek SN, Donato NJ, Wang S, Talpaz M. p53 stabilization induces apoptosis in chronic myeloid leukemia blast crisis cells. Leukemia. 25: 761-9. PMID 21350558 DOI: 10.1038/Leu.2011.7  0.34
2011 Yang J, McEachern D, Li W, Davis MA, Li H, Morgan MA, Bai L, Sebolt JT, Sun H, Lawrence TS, Wang S, Sun Y. Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases. Molecular Cancer Therapeutics. 10: 658-69. PMID 21282353 DOI: 10.1158/1535-7163.Mct-10-0643  0.344
2011 Wang S. Design of small-molecule Smac mimetics as IAP antagonists. Current Topics in Microbiology and Immunology. 348: 89-113. PMID 21072626 DOI: 10.1007/82_2010_111  0.387
2011 Azmi AS, Philip PA, Beck FWJ, Wang Z, Banerjee S, Wang S, Yang D, Sarkar FH, Mohammad RM. MI-219-zinc combination: A new paradigm in MDM2 inhibitor-based therapy Oncogene. 30: 117-126. PMID 20818437 DOI: 10.1038/Onc.2010.403  0.328
2011 Wang S, Sun W, Yu S, Zhao Y, Kumar S, McEachern D, Liu L, Bernard D, Sun D, Zou P, Li X, Yi H, Stuckey J, Long J, Malek S, et al. Abstract LB-204: Highly potent and optimized small-molecule inhibitors of MDM2 achieve complete tumor regression in animal models of solid tumors and leukemia. Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-204  0.369
2011 Sun H, Lu J, Liu L, McEachern D, Bai L, Yang C, Wang S. Abstract 3254: Novel bivalent Smac mimetics as a new class of anticancer agents Cancer Research. 71: 3254-3254. DOI: 10.1158/1538-7445.Am2011-3254  0.425
2010 Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S. Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. Journal of Medicinal Chemistry. 53: 6361-7. PMID 20684551 DOI: 10.1021/Jm100487Z  0.408
2010 Zeitlin BD, Spalding AC, Campos MS, Ashimori N, Dong Z, Wang S, Lawrence TS, Nör JE. Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation. International Journal of Radiation Oncology, Biology, Physics. 78: 879-87. PMID 20675079 DOI: 10.1016/J.Ijrobp.2010.04.024  0.307
2010 Chen J, Bai L, Bernard D, Nikolovska-Coleska Z, Gomez C, Zhang J, Yi H, Wang S. Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. Acs Medicinal Chemistry Letters. 1: 85-89. PMID 20596242 DOI: 10.1021/Ml100010J  0.674
2010 McGregor N, Patel L, Craig M, Weidner S, Wang S, Pienta KJ. AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model. Journal of Cellular Biochemistry. 110: 1187-94. PMID 20589722 DOI: 10.1002/Jcb.22633  0.309
2010 Karatas H, Townsend EC, Bernard D, Dou Y, Wang S. Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction. Journal of Medicinal Chemistry. 53: 5179-85. PMID 20575550 DOI: 10.1021/Jm100139B  0.691
2010 Sun H, Liu L, Lu J, Qiu S, Yang CY, Yi H, Wang S. Cyclopeptide Smac mimetics as antagonists of IAP proteins. Bioorganic & Medicinal Chemistry Letters. 20: 3043-6. PMID 20443226 DOI: 10.1016/J.Bmcl.2010.03.114  0.387
2010 Long J, Parkin B, Ouillette P, Bixby D, Shedden K, Erba H, Wang S, Malek SN. Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia. Blood. 116: 71-80. PMID 20404136 DOI: 10.1182/Blood-2010-01-261628  0.306
2010 Azmi AS, Aboukameel A, Banerjee S, Wang Z, Mohammad M, Wu J, Wang S, Yang D, Philip PA, Sarkar FH, Mohammad RM. MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function. European Journal of Cancer (Oxford, England : 1990). 46: 1122-31. PMID 20156675 DOI: 10.1016/J.Ejca.2010.01.015  0.32
2010 Herreros B, Wang S, Rodriguez ME, Sanchez-Beato M, Domenech E, Cordoba R, Delgado J, Garcia-Marco JA, Garcia JF, Tomás JF, Martínez-López J, Bello JL, Rodriguez A, Villuendas R, Piris MA. Targeting the Apoptotic Pathway by TW-37, a Novel Bcl-2 Family Small Molecule Inhibitor, In CLL Primary Samples Blood. 116: 2470-2470. DOI: 10.1182/Blood.V116.21.2470.2470  0.359
2010 Azmi AS, Philip PA, Aboukameel A, Banerjee S, Wang Z, Wang S, Yang D, Sarkar FH, Mohammad RM. Abstract 4535: MDM2 inhibitor MI-319 in combination with cisplatin/oxaliplatin is an effective treatment for pancreatic cancer independent of p53 function Cancer Research. 70: 4535-4535. DOI: 10.1158/1538-7445.Am10-4535  0.341
2010 Liu M, Shen C, Larsen M, Yang C, Qiu S, Tomita Y, Krajewski K, Roller PP, Stuckey J, Wang S, Nikolovska-Coleska Z. Abstract 4521: Discovery of novel small molecule inhibitors of the antiapoptotic protein Mcl-1 through high-throughput screening approach Cancer Research. 70: 4521-4521. DOI: 10.1158/1538-7445.Am10-4521  0.446
2009 Wang S, Jiang F, Bai L, Long JJ, Qiu S, Chen J, McEachern D. Effect of (-)-gossypol (AT-101) on transcriptional regulation of Noxa and Puma and on Mcl-1-mediated cancer cell resistance to apoptosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: e14611. PMID 27964122 DOI: 10.1200/Jco.2009.27.15_Suppl.E14611  0.313
2009 Mohammad RM, Wu J, Azmi AS, Aboukameel A, Sosin A, Wu S, Yang D, Wang S, Al-Katib AM. An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals. Molecular Cancer. 8: 115. PMID 19958544 DOI: 10.1186/1476-4598-8-115  0.319
2009 Yu S, Qin D, Shangary S, Chen J, Wang G, Ding K, McEachern D, Qiu S, Nikolovska-Coleska Z, Miller R, Kang S, Yang D, Wang S. Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. Journal of Medicinal Chemistry. 52: 7970-3. PMID 19928922 DOI: 10.1021/Jm901400Z  0.372
2009 Yang CY, Sun H, Chen J, Nikolovska-Coleska Z, Wang S. Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction. Journal of the American Chemical Society. 131: 13709-21. PMID 19736924 DOI: 10.1021/Ja9039373  0.323
2009 Kawamoto SA, Thompson AD, Coleska A, Nikolovska-Coleska Z, Yi H, Wang S. Analysis of the interaction of BCL9 with beta-catenin and development of fluorescence polarization and surface plasmon resonance binding assays for this interaction. Biochemistry. 48: 9534-41. PMID 19715304 DOI: 10.1021/Bi900770Z  0.782
2009 Canner JA, Sobo M, Ball S, Hutzen B, DeAngelis S, Willis W, Studebaker AW, Ding K, Wang S, Yang D, Lin J. MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. British Journal of Cancer. 101: 774-81. PMID 19707204 DOI: 10.1038/Sj.Bjc.6605199  0.369
2009 Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research. 69: 6556-64. PMID 19679550 DOI: 10.1158/0008-5472.Can-09-0891  0.33
2009 Ashimori N, Zeitlin BD, Zhang Z, Warner K, Turkienicz IM, Spalding AC, Teknos TN, Wang S, Nör JE. TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Molecular Cancer Therapeutics. 8: 893-903. PMID 19372562 DOI: 10.1158/1535-7163.Mct-08-1078  0.305
2009 Wang Z, Azmi AS, Ahmad A, Banerjee S, Wang S, Sarkar FH, Mohammad RM. TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Research. 69: 2757-65. PMID 19318573 DOI: 10.1158/0008-5472.Can-08-3060  0.379
2009 Gomez C, Bai L, Zhang J, Nikolovska-Coleska Z, Chen J, Yi H, Wang S. Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 1733-6. PMID 19243938 DOI: 10.1016/J.Bmcl.2009.01.091  0.651
2009 Sun W, Nikolovska-Coleska Z, Qin D, Sun H, Yang CY, Bai L, Qiu S, Wang Y, Ma D, Wang S. Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. Journal of Medicinal Chemistry. 52: 593-6. PMID 19138149 DOI: 10.1021/Jm801101Z  0.388
2009 Shangary S, Wang S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annual Review of Pharmacology and Toxicology. 49: 223-41. PMID 18834305 DOI: 10.1146/Annurev.Pharmtox.48.113006.094723  0.346
2009 Herreros B, Wang S, Bischoff JR, Carro R, Córdoba R, Delgado J, García-Marco JA, Gómez N, García JF, Tomáas JF, Martínez-López J, Rodríguez A, Villuendas R, Piris MA. Molecular Heterogeneity as a Basis for Rational Therapeutics in Chronic Lymphocytic Leukemia. Blood. 114: 2348-2348. DOI: 10.1182/Blood.V114.22.2348.2348  0.331
2009 Gomez C, Chen J, Wang S. Efficient synthesis of phosphotyrosine building blocks using imidazolium trifluoroacetate Tetrahedron Letters. 50: 6691-6692. DOI: 10.1016/J.Tetlet.2009.09.082  0.567
2008 Peng Y, Sun H, Nikolovska-Coleska Z, Qiu S, Yang CY, Lu J, Cai Q, Yi H, Kang S, Yang D, Wang S. Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases. Journal of Medicinal Chemistry. 51: 8158-62. PMID 19049347 DOI: 10.1021/Jm801254R  0.576
2008 Zhang B, Nikolovska-Coleska Z, Zhang Y, Bai L, Qiu S, Yang CY, Sun H, Wang S, Wu Y. Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. Journal of Medicinal Chemistry. 51: 7352-5. PMID 19012392 DOI: 10.1021/Jm801146D  0.391
2008 Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Research. 68: 9384-93. PMID 19010913 DOI: 10.1158/0008-5472.Can-08-2655  0.349
2008 Sun H, Stuckey JA, Nikolovska-Coleska Z, Qin D, Meagher JL, Qiu S, Lu J, Yang CY, Saito NG, Wang S. Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP). Journal of Medicinal Chemistry. 51: 7169-80. PMID 18954041 DOI: 10.1021/Jm8006849  0.42
2008 Sun H, Nikolovska-Coleska Z, Yang CY, Qian D, Lu J, Qiu S, Bai L, Peng Y, Cai Q, Wang S. Design of small-molecule peptidic and nonpeptidic Smac mimetics. Accounts of Chemical Research. 41: 1264-77. PMID 18937395 DOI: 10.1021/Ar8000553  0.593
2008 Macoska JA, Adsule S, Tantivejkul K, Wang S, Pienta KJ, Lee CT. -(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro. Pharmacological Research. 58: 323-31. PMID 18840529 DOI: 10.1016/J.Phrs.2008.09.005  0.331
2008 Azmi AS, Wang Z, Burikhanov R, Rangnekar VM, Wang G, Chen J, Wang S, Sarkar FH, Mohammad RM. Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis. Molecular Cancer Therapeutics. 7: 2884-93. PMID 18790769 DOI: 10.1158/1535-7163.Mct-08-0438  0.345
2008 Chen J, Collins GT, Zhang J, Yang CY, Levant B, Woods J, Wang S. Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile. Journal of Medicinal Chemistry. 51: 5905-8. PMID 18785726 DOI: 10.1021/Jm800471H  0.33
2008 Sun Y, Wu J, Aboukameel A, Banerjee S, Arnold AA, Chen J, Nikolovska-Coleska Z, Lin Y, Ling X, Yang D, Wang S, Al-Katib A, Mohammad RM. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biology & Therapy. 7: 1418-26. PMID 18769131 DOI: 10.4161/Cbt.7.9.6430  0.369
2008 Shangary S, Wang S. Targeting the MDM2-p53 interaction for cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 5318-24. PMID 18765522 DOI: 10.1158/1078-0432.Ccr-07-5136  0.332
2008 Nikolovska-Coleska Z, Meagher JL, Jiang S, Yang CY, Qiu S, Roller PP, Stuckey JA, Wang S. Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein. Biochemistry. 47: 9811-24. PMID 18717598 DOI: 10.1021/Bi800785Y  0.397
2008 Shangary S, Ding K, Qiu S, Nikolovska-Coleska Z, Bauer JA, Liu M, Wang G, Lu Y, McEachern D, Bernard D, Bradford CR, Carey TE, Wang S. Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. Molecular Cancer Therapeutics. 7: 1533-42. PMID 18566224 DOI: 10.1158/1535-7163.Mct-08-0140  0.52
2008 Wang Z, Song W, Aboukameel A, Mohammad M, Wang G, Banerjee S, Kong D, Wang S, Sarkar FH, Mohammad RM. TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer. International Journal of Cancer. Journal International Du Cancer. 123: 958-66. PMID 18528859 DOI: 10.1002/Ijc.23610  0.36
2008 Bixby D, Kujawski L, Wang S, Malek SN. The pre-clinical development of MDM2 inhibitors in chronic lymphocytic leukemia uncovers a central role for p53 status in sensitivity to MDM2 inhibitor-mediated apoptosis. Cell Cycle (Georgetown, Tex.). 7: 971-9. PMID 18414049 DOI: 10.4161/Cc.7.8.5754  0.377
2008 Sikora MJ, Bauer JA, Verhaegen M, Belbin TJ, Prystowsky MB, Taylor JC, Brenner JC, Wang S, Soengas MS, Bradford CR, Carey TE. Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. Cancer Biology & Therapy. 7: 767-76. PMID 18376141 DOI: 10.4161/Cbt.7.5.5767  0.303
2008 Sun SH, Zheng M, Ding K, Wang S, Sun Y. A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Biology & Therapy. 7: 845-52. PMID 18340116 DOI: 10.4161/Cbt.7.6.5841  0.329
2008 Boehm AL, Sen M, Seethala R, Gooding WE, Freilino M, Wong SM, Wang S, Johnson DE, Grandis JR. Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. Molecular Pharmacology. 73: 1632-42. PMID 18326051 DOI: 10.1124/Mol.107.044636  0.328
2008 Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, ... ... Wang S, et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proceedings of the National Academy of Sciences of the United States of America. 105: 3933-8. PMID 18316739 DOI: 10.1073/Pnas.0708917105  0.556
2008 Arnold AA, Aboukameel A, Chen J, Yang D, Wang S, Al-Katib A, Mohammad RM. Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. Molecular Cancer. 7: 20. PMID 18275607 DOI: 10.1186/1476-4598-7-20  0.365
2008 Tang G, Nikolovska-Coleska Z, Qiu S, Yang CY, Guo J, Wang S. Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins Journal of Medicinal Chemistry. 51: 717-720. PMID 18237106 DOI: 10.1021/Jm701358V  0.401
2008 Nikolovska-Coleska Z, Meagher JL, Jiang S, Kawamoto SA, Gao W, Yi H, Qin D, Roller PP, Stuckey JA, Wang S. Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains. Analytical Biochemistry. 374: 87-98. PMID 18023397 DOI: 10.1016/J.Ab.2007.10.032  0.792
2008 Saddler C, Ouillette P, Kujawski L, Shangary S, Talpaz M, Kaminski M, Erba H, Shedden K, Wang S, Malek SN. Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia. Blood. 111: 1584-93. PMID 17971485 DOI: 10.1182/Blood-2007-09-112698  0.331
2008 Peterson LF, Wang S, Talpaz M. Enhanced Cytotoxicity in Chronic Myeloid Leukemia Primitive Progenitors by the Combined Action of Imatinib and An HDM2-Inhibitor Blood. 112: 3213-3213. DOI: 10.1182/Blood.V112.11.3213.3213  0.331
2008 Long J, Ouillette P, Parkin B, Erba H, Wang S, Malek S. Identification of p53 Aberration-Dependent as Well as Non-p53-Mediated Resistance to MDM2 Inhibitors in Acute Myelogenous Leukemia. Blood. 112: 1607-1607. DOI: 10.1182/Blood.V112.11.1607.1607  0.328
2008 Wang S. Abstract ED01-01: Use of natural products as the scaffolds for the design of molecularly targeted agents for cancer treatment and prevention Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-Ed01-01  0.389
2008 Wang Z, Azmi AS, Banerjee S, Aboukameel A, Wang S, Sarkar FH, Mohammad RM. TW-37 INHIBITS CELL GROWTH AND INDUCES APOPTOSIS IN PANCREATIC CANCER Pancreas. 37: 500. DOI: 10.1097/01.Mpa.0000335408.77670.4A  0.306
2007 Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, Qiu S, Tomita Y, Ueda Y, Jiang S, Krajewski K, Roller PP, Stuckey JA, Wang S. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. Journal of the American Chemical Society. 129: 15279-94. PMID 17999504 DOI: 10.1021/Ja074725F  0.39
2007 Bowman AL, Nikolovska-Coleska Z, Zhong H, Wang S, Carlson HA. Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models. Journal of the American Chemical Society. 129: 12809-14. PMID 17902662 DOI: 10.1021/Ja073687X  0.403
2007 Tang G, Ding K, Nikolovska-Coleska Z, Yang CY, Qiu S, Shangary S, Wang R, Guo J, Gao W, Meagher J, Stuckey J, Krajewski K, Jiang S, Roller PP, Wang S. Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. Journal of Medicinal Chemistry. 50: 3163-6. PMID 17552510 DOI: 10.1021/Jm070383C  0.403
2007 Wolter KG, Verhaegen M, Fernández Y, Nikolovska-Coleska Z, Riblett M, de la Vega CM, Wang S, Soengas MS. Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. Cell Death and Differentiation. 14: 1605-16. PMID 17541428 DOI: 10.1038/Sj.Cdd.4402163  0.319
2007 Chen J, Nikolovska-Coleska Z, Yang CY, Gomez C, Gao W, Krajewski K, Jiang S, Roller P, Wang S. Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'. Bioorganic & Medicinal Chemistry Letters. 17: 3939-42. PMID 17513110 DOI: 10.1016/J.Bmcl.2007.04.096  0.646
2007 Mohammad RM, Goustin AS, Aboukameel A, Chen B, Banerjee S, Wang G, Nikolovska-Coleska Z, Wang S, Al-Katib A. Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2226-35. PMID 17404107 DOI: 10.1158/1078-0432.Ccr-06-1574  0.314
2007 Zhang M, Ling Y, Yang CY, Liu H, Wang R, Wu X, Ding K, Zhu F, Griffith BN, Mohammad RM, Wang S, Yang D. A novel Bcl-2 small molecule inhibitor 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB)-induced apoptosis in leukemia cells. Annals of Hematology. 86: 471-81. PMID 17396262 DOI: 10.1007/S00277-007-0288-4  0.34
2007 Tang G, Yang CY, Nikolovska-Coleska Z, Guo J, Qiu S, Wang R, Gao W, Wang G, Stuckey J, Krajewski K, Jiang S, Roller PP, Wang S. Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. Journal of Medicinal Chemistry. 50: 1723-6. PMID 17378545 DOI: 10.1021/Jm061400L  0.408
2007 Pamarthy D, Tan M, Wu M, Chen J, Yang D, Wang S, Zhang H, Sun Y. p27 degradation by an ellipticinium series of compound via ubiquitin-proteasome pathway. Cancer Biology & Therapy. 6: 360-6. PMID 17312389 DOI: 10.4161/Cbt.6.3.3703  0.342
2007 Zhang M, Fang X, Liu H, Guo R, Wu X, Li B, Zhu F, Ling Y, Griffith BN, Wang S, Yang D. Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells. Cancer Letters. 252: 244-58. PMID 17293030 DOI: 10.1016/J.Canlet.2006.12.035  0.38
2007 Lu Y, Wang R, Yang CY, Wang S. Analysis of ligand-bound water molecules in high-resolution crystal structures of protein-ligand complexes. Journal of Chemical Information and Modeling. 47: 668-75. PMID 17266298 DOI: 10.1021/Ci6003527  0.469
2007 Sadowsky JD, Fairlie WD, Hadley EB, Lee HS, Umezawa N, Nikolovska-Coleska Z, Wang S, Huang DC, Tomita Y, Gellman SH. (alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions. Journal of the American Chemical Society. 129: 139-54. PMID 17199293 DOI: 10.1021/Ja0662523  0.308
2007 Zhang M, Fang X, Liu H, Wang S, Yang D. Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP). Biochemical Pharmacology. 73: 15-24. PMID 16950208 DOI: 10.1016/J.Bcp.2006.07.034  0.351
2007 Mohammad RM, Sun Y, Wang S, Aboukameel A, Al-Katib AM. Evaluation of TW-37, a pan Bcl-2 Proteins Small-Molecule Inhibitor, Against Spectrum of Human B-Cell Lines and Patient-Derived Samples. Blood. 110: 4521-4521. DOI: 10.1182/Blood.V110.11.4521.4521  0.372
2007 Goustin A, Giri A, Wang S, Al-Katib A, Ramzi MM. Surface Plasmon Resonance Study of Apoptotic Regulators Bcl-2, Bcl-w, Bcl-XL, and Mcl-1 Indicate That the Preclinical Small Molecule Inhibitor (SMI) TW-37 Binds to the Hydrophobic Groove Competitively with tBid To Form a Heterodimer Which Cannot Be Disrupted by 200-Fold Molar Excess of TW-37. Blood. 110: 1606-1606. DOI: 10.1182/Blood.V110.11.1606.1606  0.379
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2006 Lu Y, Yang CY, Wang S. Binding free energy contributions of interfacial waters in HIV-1 protease/inhibitor complexes. Journal of the American Chemical Society. 128: 11830-9. PMID 16953623 DOI: 10.1021/Ja058042G  0.493
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2006 Song YL, Peach ML, Roller PP, Qiu S, Wang S, Long YQ. Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives. Journal of Medicinal Chemistry. 49: 1585-1596. PMID 16509576 DOI: 10.1021/Jm050910X  0.355
2006 Tang HJ, Jin X, Wang S, Yang D, Cao Y, Chen J, Gossett DR, Lin J. A small molecule compound inhibits AKT pathway in ovarian cancer cell lines. Gynecologic Oncology. 100: 308-17. PMID 16209885 DOI: 10.1016/J.Ygyno.2005.08.044  0.345
2006 Yang CY, Wang S. Chapter 11 Recent Advances in Design of Small-Molecule Ligands to Target Protein–Protein Interactions Annual Reports in Computational Chemistry. 2: 197-219. DOI: 10.1016/S1574-1400(06)02011-1  0.339
2006 Peng Y, Sun H, Wang S. Design and synthesis of a 1,5-diazabicyclo[6,3,0] dodecane amino acid derivative as a novel dipeptide reverse-turn mimetic Tetrahedron Letters. 47: 4769-4770. DOI: 10.1016/J.Tetlet.2006.04.053  0.487
2005 Faden AI, Movsesyan VA, Fang X, Wang S. Identification of novel neuroprotective agents using pharmacophore modeling. Chemistry & Biodiversity. 2: 1564-70. PMID 17191955 DOI: 10.1002/Cbdv.200590127  0.323
2005 Mohammad RM, Wang S, Banerjee S, Wu X, Chen J, Sarkar FH. Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. Pancreas. 31: 317-24. PMID 16258364 DOI: 10.1097/01.Mpa.0000179731.46210.01  0.387
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2005 Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang S, Tomita Y, Gellman SH. Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. Journal of the American Chemical Society. 127: 11966-8. PMID 16117535 DOI: 10.1021/Ja053678T  0.32
2005 Ding K, Lu Y, Nikolovska-Coleska Z, Qiu S, Ding Y, Gao W, Stuckey J, Krajewski K, Roller PP, Tomita Y, Parrish DA, Deschamps JR, Wang S. Structure-based design of potent non-peptide MDM2 inhibitors. Journal of the American Chemical Society. 127: 10130-1. PMID 16028899 DOI: 10.1021/Ja051147Z  0.567
2005 Wang R, Fang X, Lu Y, Yang CY, Wang S. The PDBbind database: methodologies and updates. Journal of Medicinal Chemistry. 48: 4111-9. PMID 15943484 DOI: 10.1021/Jm048957Q  0.499
2005 Ding K, Chen J, Ji M, Wu X, Varady J, Yang CY, Lu Y, Deschamps JR, Levant B, Wang S. Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands. Journal of Medicinal Chemistry. 48: 3171-81. PMID 15857123 DOI: 10.1021/Jm049031L  0.464
2005 Song H, Wang R, Wang S, Lin J. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 4700-5. PMID 15781862 DOI: 10.1073/Pnas.0409894102  0.354
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2005 Sun H, Nikolovska-Coleska Z, Chen J, Yang CY, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics. Bioorganic & Medicinal Chemistry Letters. 15: 793-7. PMID 15664859 DOI: 10.1016/J.Bmcl.2004.11.008  0.426
2005 Sun H, Nikolovska-Coleska Z, Yang CY, Wang S. Design and synthesis of a potent biotinylated Smac mimetic Tetrahedron Letters. 46: 7015-7018. DOI: 10.1016/J.Tetlet.2005.08.055  0.356
2004 Ellis KL, Mohammad R, Wang S, Wu X, Chen J, Min J, Sarkar FH. Potentiation of apoptosis inducing activity of BL-193, an inhibitor of Bcl-XL protein, by genistein in pancreatic cancer cells. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3133. PMID 28014863 DOI: 10.1200/Jco.2004.22.14_Suppl.3133  0.35
2004 Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Liu M, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Structure-based design of potent, conformationally constrained Smac mimetics. Journal of the American Chemical Society. 126: 16686-7. PMID 15612682 DOI: 10.1021/Ja047438+  0.4
2004 Oliver CL, Bauer JA, Wolter KG, Ubell ML, Narayan A, O'Connell KM, Fisher SG, Wang S, Wu X, Ji M, Carey TE, Bradford CR. In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7757-63. PMID 15570010 DOI: 10.1158/1078-0432.Ccr-04-0551  0.321
2004 Wang R, Lu Y, Fang X, Wang S. An extensive test of 14 scoring functions using the PDBbind refined set of 800 protein-ligand complexes. Journal of Chemical Information and Computer Sciences. 44: 2114-25. PMID 15554682 DOI: 10.1021/Ci049733J  0.476
2004 Real PJ, Cao Y, Wang R, Nikolovska-Coleska Z, Sanz-Ortiz J, Wang S, Fernandez-Luna JL. Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2. Cancer Research. 64: 7947-53. PMID 15520201 DOI: 10.1158/0008-5472.Can-04-0945  0.378
2004 Jin X, Gossett DR, Wang S, Yang D, Cao Y, Chen J, Guo R, Reynolds RK, Lin J. Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells British Journal of Cancer. 91: 1808-1812. PMID 15505622 DOI: 10.1038/Sj.Bjc.6602214  0.334
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2004 Blobaum AL, Lu Y, Kent UM, Wang S, Hollenberg PF. Formation of a novel reversible cytochrome P450 spectral intermediate: role of threonine 303 in P450 2E1 inactivation. Biochemistry. 43: 11942-52. PMID 15379534 DOI: 10.1021/Bi048882S  0.473
2004 Nikolovska-Coleska Z, Wang R, Fang X, Pan H, Tomita Y, Li P, Roller PP, Krajewski K, Saito NG, Stuckey JA, Wang S. Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization. Analytical Biochemistry. 332: 261-73. PMID 15325294 DOI: 10.1016/J.Ab.2004.05.055  0.396
2004 Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Tomita Y, Krajewski K, Roller PP, Wang S. Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. Journal of Medicinal Chemistry. 47: 4147-50. PMID 15293984 DOI: 10.1021/Jm0499108  0.377
2004 Wang R, Fang X, Lu Y, Wang S. The PDBbind database: collection of binding affinities for protein-ligand complexes with known three-dimensional structures. Journal of Medicinal Chemistry. 47: 2977-80. PMID 15163179 DOI: 10.1021/Jm030580L  0.491
2004 Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, Wang S. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. Journal of Medicinal Chemistry. 47: 2430-40. PMID 15115387 DOI: 10.1021/jm030420  0.43
2004 Fang X, Shao L, Zhang H, Wang S. Web-based tools for mining the NCI databases for anticancer drug discovery. Journal of Chemical Information and Computer Sciences. 44: 249-57. PMID 14741034 DOI: 10.1021/Ci034209I  0.318
2004 Mohammad R, Wang S, Wu X, Chen J, Min J, Sarkar F. POTENTIATION OF APOPTOSIS INDUCING ACTIVITY OF BL-193, A NONPEPTIDIC SMALL-MOLECULE INHIBITOR OF BCL-2/BCL-XL PROTEINS, BY GENISTEIN IN PANCREATIC CANCER CELLS. Pancreas. 29: 364. DOI: 10.1097/00006676-200411000-00145  0.364
2003 Wang S, Yang D, Lippman ME. Targeting Bcl-2 and Bcl-XL with nonpeptidic small-molecule antagonists. Seminars in Oncology. 30: 133-42. PMID 14613034 DOI: 10.1053/J.Seminoncol.2003.08.015  0.33
2003 Varady J, Wu X, Fang X, Min J, Hu Z, Levant B, Wang S. Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach. Journal of Medicinal Chemistry. 46: 4377-92. PMID 14521403 DOI: 10.1021/Jm030085P  0.31
2003 Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Roller PP, Wang S, Yang D. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochemical Pharmacology. 66: 93-103. PMID 12818369 DOI: 10.1016/S0006-2952(03)00248-X  0.306
2003 Wang R, Lu Y, Wang S. Comparative evaluation of 11 scoring functions for molecular docking. Journal of Medicinal Chemistry. 46: 2287-303. PMID 12773034 DOI: 10.1021/Jm0203783  0.456
2002 Rong SB, Zhang J, Neale JH, Wroblewski JT, Wang S, Kozikowski AP. Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors. Journal of Medicinal Chemistry. 45: 4140-52. PMID 12213057 DOI: 10.1021/Jm010561G  0.315
2002 Enyedy IJ, Wang J, Zaman WA, Johnson KM, Wang S. Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol. Bioorganic & Medicinal Chemistry Letters. 12: 1775-8. PMID 12067559 DOI: 10.1016/S0960-894X(02)00243-3  0.315
2002 Rong SB, Enyedy IJ, Qiao L, Zhao L, Ma D, Pearce LL, Lorenzo PS, Stone JC, Blumberg PM, Wang S, Kozikowski AP. Structural basis of RasGRP binding to high-affinity PKC ligands. Journal of Medicinal Chemistry. 45: 853-60. PMID 11831896 DOI: 10.1021/Jm010422Z  0.303
2002 Long YQ, Lee SL, Lin CY, Enyedy IJ, Wang S, Li P, Dickson RB, Roller PP. Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. Bioorganic & Medicinal Chemistry Letters. 11: 2515-9. PMID 11549459 DOI: 10.1016/S0960-894X(01)00493-0  0.329
2001 Enyedy IJ, Ling Y, Nacro K, Tomita Y, Wu X, Cao Y, Guo R, Li B, Zhu X, Huang Y, Long Y, Roller PP, Yang D, Wang S. Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening Journal of Medicinal Chemistry. 44: 4313-4324. PMID 11728179 DOI: 10.1021/Jm010016F  0.401
2001 Shao L, Lewin NE, Lorenzo PS, Hu Z, Enyedy IJ, Garfield SH, Stone JC, Marner FJ, Blumberg PM, Wang S. Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily. Journal of Medicinal Chemistry. 44: 3872-80. PMID 11689073 DOI: 10.1021/Jm010258F  0.366
2001 Lung FD, Long YQ, Roller PP, King CR, Varady J, Wu XW, Wang S. Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 447-54. PMID 11437948 DOI: 10.1034/J.1399-3011.2001.00833.X  0.321
2001 Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM. Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry. 9: 1753-64. PMID 11425577 DOI: 10.1016/S0968-0896(01)00090-6  0.346
2001 Pak Y, Enyedy IJ, Varady J, Kung JW, Lorenzo PS, Blumberg PM, Wang S. Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis. Journal of Medicinal Chemistry. 44: 1690-701. PMID 11356104 DOI: 10.1021/Jm000488E  0.309
2001 Enyedy IJ, Zaman WA, Sakamuri S, Kozikowski AP, Johnson KM, Wang S. Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 1113-8. PMID 11354356 DOI: 10.1016/S0960-894X(01)00132-9  0.309
2001 Qiao L, Zhao LY, Rong SB, Wu XW, Wang S, Fujii T, Kazanietz MG, Rauser L, Savage J, Roth BL, Flippen-Anderson J, Kozikowski AP. Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. Bioorganic & Medicinal Chemistry Letters. 11: 955-9. PMID 11327599 DOI: 10.1016/S0960-894X(01)00097-X  0.368
2001 Enyedy IJ, Lee SL, Kuo AH, Dickson RB, Lin CY, Wang S. Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase Journal of Medicinal Chemistry. 44: 1349-1355. PMID 11311057 DOI: 10.1021/Jm000395X  0.375
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2000 Hu Y, Qiao L, Wang S, Rong SB, Meuillet EJ, Berggren M, Gallegos A, Powis G, Kozikowski AP. 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth. Journal of Medicinal Chemistry. 43: 3045-51. PMID 10956212 DOI: 10.1021/Jm000117Y  0.345
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1995 Nicklaus MC, Wang S, Driscoll JS, Milne GWA. Conformational changes of small molecules binding to proteins Bioorganic & Medicinal Chemistry. 3: 411-428. PMID 8581425 DOI: 10.1016/0968-0896(95)00031-B  0.325
1995 Wang S, Zaharevitz DW, Sharma R, Marquez VE, Lewin NE, Du L, Blumberg PM, Milne GW. The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies. Journal of Medicinal Chemistry. 37: 4479-89. PMID 7799398 DOI: 10.1021/Jm00052A007  0.352
1995 Acs G, Lee J, Marquez VE, Wang S, Milne GW, Du L, Lewin NE, Blumberg PM. Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids. Journal of Neurochemistry. 65: 301-18. PMID 7790875 DOI: 10.1046/J.1471-4159.1995.65010301.X  0.348
1995 Kazanietz MG, Wang S, Milne GW, Lewin NE, Liu HL, Blumberg PM. Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis. The Journal of Biological Chemistry. 270: 21852-9. PMID 7665608 DOI: 10.1074/Jbc.270.37.21852  0.334
1994 Wang S, Milne GW, Klopman G. Graph theory and group contributions in the estimation of boiling points. Journal of Chemical Information and Computer Sciences. 34: 1242-50. PMID 7989396 DOI: 10.1021/Ci00022A004  0.49
1994 Klopman G, Li JY, Wang S, Pearson AJ, Chang K, Jacobs MR, Bajaksouzian S, Ellner JJ. In vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerations. Antimicrobial Agents and Chemotherapy. 38: 1794-802. PMID 7986010 DOI: 10.1128/Aac.38.8.1794  0.513
1993 Klopman G, Wang S, Jacobs MR, Ellner JJ. Anti-Mycobacterium avium activity of quinolones: structure-activity relationship studies. Antimicrobial Agents and Chemotherapy. 37: 1807-15. PMID 8239588 DOI: 10.1128/Aac.37.9.1807  0.517
1993 Klopman G, Wang S, Jacobs MR, Bajaksouzian S, Edmonds K, Ellner JJ. Anti-Mycobacterium avium activity of quinolones: in vitro activities. Antimicrobial Agents and Chemotherapy. 37: 1799-806. PMID 8239587 DOI: 10.1128/Aac.37.9.1799  0.478
1993 Klopman G, Li JY, Wang S, Dimayuga M. Computer automated log P calculations based on an extended group contribution approach Journal of Chemical Information and Computer Sciences. 33: 752-781. DOI: 10.1021/Ci00020A009  0.475
1992 Klopman G, Wang S, Balthasar DM. Estimation of aqueous solubility of organic molecules by the group contribution approach. Application to the study of biodegradation. Journal of Chemical Information and Computer Sciences. 32: 474-82. PMID 1400663 DOI: 10.1021/Ci00009A013  0.496
1991 Klopman G, Wang S. A computer automated structure evaluation (CASE) approach to calculation of partition coefficient Journal of Computational Chemistry. 12: 1025-1032. DOI: 10.1002/Jcc.540120815  0.505
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