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James Chadwick, Ph.D. - Publications

Affiliations: 
1935-1948 University of Liverpool, Liverpool, England, United Kingdom 
 1943-1946 Los Alamos National Laboratory, Los Alamos, NM, United States 
 1948-1962 University of Cambridge, Cambridge, England, United Kingdom 
Area:
nuclear physics
Website:
http://nobelprize.org/nobel_prizes/physics/laureates/1935/chadwick-bio.html
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Amewu RK, Chadwick J, Hussain A, Panda S, Rinki R, Janneh O, Ward SA, Miguel C, Burrell-Saward H, Vivas L, O'Neill PM. Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers. Bioorganic & Medicinal Chemistry. 21: 7392-7. PMID 24148834 DOI: 10.1016/J.Bmc.2013.09.047  0.344
2013 Mok NY, Chadwick J, Kellett KA, Casas-Arce E, Hooper NM, Johnson AP, Fishwick CW. Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. Journal of Medicinal Chemistry. 56: 1843-52. PMID 23374014 DOI: 10.1021/Jm301127X  0.339
2012 Copple IM, Mercer AE, Firman J, Donegan G, Herpers B, Wong MH, Chadwick J, Bringela AD, Cristiano ML, van de Water B, Ward SA, O'Neill PM, Park BK. Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials. Molecular Medicine (Cambridge, Mass.). 18: 1045-55. PMID 22669474 DOI: 10.2119/Molmed.2012.00154  0.373
2012 Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, ... ... Chadwick J, et al. Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proceedings of the National Academy of Sciences of the United States of America. 109: 8298-303. PMID 22566611 DOI: 10.1073/Pnas.1205651109  0.375
2012 Sharma R, Lawrenson AS, Fisher NE, Warman AJ, Shone AE, Hill A, Mbekeani A, Pidathala C, Amewu RK, Leung S, Gibbons P, Hong DW, Stocks P, Nixon GL, Chadwick J, et al. Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods. Journal of Medicinal Chemistry. 55: 3144-54. PMID 22380711 DOI: 10.1021/Jm3001482  0.367
2011 Chadwick J, Amewu RK, Marti F, Garah FB, Sharma R, Berry NG, Stocks PA, Burrell-Saward H, Wittlin S, Rottmann M, Brun R, Taramelli D, Parapini S, Ward SA, O'Neill PM. Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. Chemmedchem. 6: 1357-61. PMID 21692184 DOI: 10.1002/Cmdc.201100196  0.313
2011 Marti F, Chadwick J, Amewu RK, Burrell-Saward H, Srivastava A, Ward SA, Sharma R, Berry N, O'Neill PM. Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities Medchemcomm. 2: 661-665. DOI: 10.1039/C1Md00102G  0.34
2010 Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, et al. Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. Journal of Medicinal Chemistry. 53: 8202-6. PMID 20979352 DOI: 10.1021/Jm1009567  0.348
2010 Barton V, Ward SA, Chadwick J, Hill A, O'Neill PM. Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics. Journal of Medicinal Chemistry. 53: 4555-9. PMID 20476788 DOI: 10.1021/Jm100201J  0.308
2010 Chadwick J, Jones M, Mercer AE, Stocks PA, Ward SA, Park BK, O'Neill PM. Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines. Bioorganic & Medicinal Chemistry. 18: 2586-97. PMID 20227283 DOI: 10.1016/J.Bmc.2010.02.035  0.343
2010 Biagini GA, Hill A, Mbekeani A, Shone A, Nixon G, Stocks P, Gibbons P, Amewu R, Hong DW, Barton V, Pidathala C, Chadwick J, Le Pensee L, Warman A, Sharma R, et al. Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH:quinone oxidoreductase Malaria Journal. 9. DOI: 10.1186/1475-2875-9-S2-O4  0.412
2010 Ward SA, Fisher N, Hill A, Mbekeani A, Shone A, Nixon G, Stocks P, Gibbons P, Amewu R, Hong DW, Barton V, Pidathala C, Chadwick J, Le Pensee L, Warman A, et al. A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum Malaria Journal. 9. DOI: 10.1186/1475-2875-9-S2-I14  0.383
2010 Fisher N, Hill A, Mbekeani A, Shone A, Nixon G, Stocks P, Gibbons P, Amewu R, Hong WD, Barton V, Pidathala C, Chadwick J, Le Pensee L, Warman A, Sharma R, et al. A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1797: 80. DOI: 10.1016/J.Bbabio.2010.04.241  0.323
2009 Yi Mok N, Chadwick J, Kellett KA, Hooper NM, Johnson AP, Fishwick CW. Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. Bioorganic & Medicinal Chemistry Letters. 19: 6770-4. PMID 19854048 DOI: 10.1016/J.Bmcl.2009.09.103  0.321
2009 Chadwick J, Mercer AE, Park BK, Cosstick R, O'Neill PM. Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells. Bioorganic & Medicinal Chemistry. 17: 1325-38. PMID 19136263 DOI: 10.1016/J.Bmc.2008.12.017  0.357
2009 O'Neill PM, Chadwick J, Rawe SL. Biomimetic Fe(II) Chemistry and Synthetic Studies on Antimalarial and Antitumour Endoperoxides Patai's Chemistry of Functional Groups. 1279-1346. DOI: 10.1002/9780470682531.Pat0363  0.321
2007 Mercer AE, Maggs JL, Sun XM, Cohen GM, Chadwick J, O'Neill PM, Park BK. Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds. The Journal of Biological Chemistry. 282: 9372-82. PMID 17227762 DOI: 10.1074/Jbc.M610375200  0.338
2004 Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin. Journal of Medicinal Chemistry. 47: 1290-8. PMID 14971909 DOI: 10.1021/Jm030974C  0.364
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