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John R. Engen - Publications

Affiliations: 
Chemistry and Chemical Biology Northeastern University, Boston, MA, United States 
Area:
Bioanalytical chemistry, mass spectrometry, hydrogen/deuterium exchange
Website:
https://neu.hxms.com
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192 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wales TE, Pajak A, Roeselová A, Shivakumaraswamy S, Howell S, Kjær S, Hartl FU, Engen JR, Balchin D. Resolving chaperone-assisted protein folding on the ribosome at the peptide level. Nature Structural & Molecular Biology. PMID 38987455 DOI: 10.1038/s41594-024-01355-x  0.652
2024 Woo JR, Bae SH, Wales TE, Engen JR, Lee J, Jang H, Park S. The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction. Proceedings of the National Academy of Sciences of the United States of America. 121: e2401716121. PMID 38625937 DOI: 10.1073/pnas.2401716121  0.62
2024 McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. Covalent inhibition of pro-apoptotic BAX. Nature Chemical Biology. PMID 38233584 DOI: 10.1038/s41589-023-01537-6  0.599
2024 Marie AL, Georgescauld F, Johnson KR, Ray S, Engen JR, Ivanov AR. Native Capillary Electrophoresis-Mass Spectrometry of Near 1 MDa Non-Covalent GroEL/GroES/Substrate Protein Complexes. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2306824. PMID 38191978 DOI: 10.1002/advs.202306824  0.31
2024 Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife. 12. PMID 38189455 DOI: 10.7554/eLife.89489  0.646
2023 Joseph RE, Wales TE, Jayne S, Britton RG, Fulton DB, Engen JR, Dyer MJS, Andreotti AH. Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. Biorxiv : the Preprint Server For Biology. PMID 38187560 DOI: 10.1101/2023.12.18.572223  0.607
2023 Lin DY, Kueffer LE, Juneja P, Wales T, Engen JR, Andreotti AH. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Biorxiv : the Preprint Server For Biology. PMID 37786675 DOI: 10.1101/2023.06.02.543453  0.648
2023 A M, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, ... ... Engen JR, et al. Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α. Molecular Cell. 83: 1903-1920.e12. PMID 37267907 DOI: 10.1016/j.molcel.2023.05.008  0.593
2023 Ayaz P, Lyczek A, Paung Y, Mingione VR, Iacob RE, de Waal PW, Engen JR, Seeliger MA, Shan Y, Shaw DE. Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature Communications. 14: 1885. PMID 37019905 DOI: 10.1038/s41467-023-36956-5  0.321
2022 Peterle D, DePice D, Wales TE, Engen JR. Increase the flow rate and improve hydrogen deuterium exchange mass spectrometry. Journal of Chromatography. A. 1689: 463742. PMID 36586285 DOI: 10.1016/j.chroma.2022.463742  0.585
2022 Du S, Alvarado JJ, Wales TE, Moroco JA, Engen JR, Smithgall TE. ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure (London, England : 1993). PMID 36115344 DOI: 10.1016/j.str.2022.08.008  0.654
2022 Peterle D, Wales TE, Engen JR. Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments. Analytical Chemistry. PMID 35796687 DOI: 10.1021/acs.analchem.2c01446  0.638
2022 Prew MS, Camara CM, Botzanowski T, Moroco JA, Bloch NB, Levy HR, Seo HS, Dhe-Paganon S, Bird GH, Herce HD, Gygi MA, Escudero S, Wales TE, Engen JR, Walensky LD. Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nature Communications. 13: 3669. PMID 35760926 DOI: 10.1038/s41467-022-31466-2  0.612
2021 Joseph RE, Lowe J, Fulton DB, Engen JR, Wales TE, Andreotti AH. The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. Journal of Molecular Biology. 434: 167422. PMID 34954235 DOI: 10.1016/j.jmb.2021.167422  0.61
2021 Ji Z, Li H, Peterle D, Paulo JA, Ficarro SB, Wales TE, Marto JA, Gygi SP, Engen JR, Rapoport TA. Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase. Molecular Cell. PMID 34951965 DOI: 10.1016/j.molcel.2021.11.033  0.629
2021 Peterle D, Klimtchuk ES, Wales TE, Georgescauld F, Connors LH, Engen JR, Gursky O. A conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation. Journal of Molecular Biology. 167310. PMID 34678302 DOI: 10.1016/j.jmb.2021.167310  0.629
2021 James EI, Murphree TA, Vorauer C, Engen JR, Guttman M. Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems. Chemical Reviews. PMID 34493042 DOI: 10.1021/acs.chemrev.1c00279  0.319
2021 Bloch NB, Wales TE, Prew MS, Levy HR, Engen JR, Walensky LD. The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature Communications. 12: 4932. PMID 34389733 DOI: 10.1038/s41467-021-25200-7  0.638
2020 Joseph RE, Amatya N, Fulton DB, Engen JR, Wales TE, Andreotti A. Differential impact of BTK active site inhibitors on the conformational state of full-length BTK. Elife. 9. PMID 33226337 DOI: 10.7554/eLife.60470  0.642
2020 Engen JR, Botzanowski T, Peterle D, Georgescauld F, Wales TE. Developments in Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical Chemistry. PMID 33112590 DOI: 10.1021/acs.analchem.0c04281  0.603
2020 Staudt RP, Alvarado JJ, Emert-Sedlak LA, Shi H, Shu ST, Wales TE, Engen JR, Smithgall TE. Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. The Journal of Biological Chemistry. PMID 32862141 DOI: 10.1074/Jbc.Rev120.012317  0.636
2020 Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nature Chemical Biology. PMID 32807965 DOI: 10.1038/S41589-020-0625-7  0.632
2020 Vetter CJ, Thorn DC, Wheeler SG, Mundorff C, Halverson K, Wales TE, Shinde U, Engen JR, David LL, Carver JA, Lampi KJ. Cumulative deamidations of the major lens protein γS-crystallin increase its aggregation during unfolding and oxidation. Protein Science : a Publication of the Protein Society. PMID 32697405 DOI: 10.1002/Pro.3915  0.631
2020 Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nature Structural & Molecular Biology. PMID 32661419 DOI: 10.1038/S41594-020-0458-9  0.645
2020 Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, ... ... Engen JR, et al. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Molecular Cell. PMID 32533918 DOI: 10.1016/J.Molcel.2020.05.029  0.644
2020 Engen JR, Komives EA. Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy. Trends in Biochemical Sciences. PMID 32487353 DOI: 10.1016/J.Tibs.2020.05.005  0.404
2020 Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, et al. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology. PMID 32413285 DOI: 10.1016/J.Chembiol.2020.04.004  0.664
2020 Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure (London, England : 1993). PMID 32359398 DOI: 10.1016/J.Str.2020.04.011  0.62
2020 Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD. Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. Acs Chemical Biology. PMID 32348108 DOI: 10.1021/Acschembio.0C00308  0.603
2020 Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell Reports. 30: 3229-3239.e6. PMID 32160532 DOI: 10.1016/J.Celrep.2020.02.057  0.662
2020 Fleischhacker AS, Gunawan AL, Kochert BA, Liu L, Wales TE, Borowy MC, Engen JR, Ragsdale SW. The heme regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation. The Journal of Biological Chemistry. PMID 32152224 DOI: 10.1074/Jbc.Ra120.012803  0.792
2020 Kardon JR, Moroco JA, Engen JR, Baker TA. Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding. Elife. 9. PMID 32091391 DOI: 10.7554/Elife.54387  0.377
2020 Makarov AA, Iacob RE, Pirrone GF, Rodriguez-Granillo A, Joyce L, Mangion I, Moore JC, Sherer EC, Engen JR. Combination of HDX-MS and in silico modeling to study enzymatic reactivity and stereo-selectivity at different solvent conditions. Journal of Pharmaceutical and Biomedical Analysis. 182: 113141. PMID 32036298 DOI: 10.1016/J.Jpba.2020.113141  0.783
2020 Frame NM, Kumanan M, Wales TE, Bandara A, Fändrich M, Straub JE, Engen JR, Gursky O. Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A. Journal of Molecular Biology. PMID 32035904 DOI: 10.1016/J.Jmb.2020.01.029  0.667
2020 Manthei KA, Patra D, Wilson CJ, Fawaz MV, Piersimoni L, Shenkar JC, Yuan W, Andrews PC, Engen JR, Schwendeman A, Ohi MD, Tesmer JJG. Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles. Communications Biology. 3: 28. PMID 31942029 DOI: 10.1038/s42003-019-0749-z  0.476
2020 Eggertson MJ, Fadgen K, Engen JR, Wales TE. Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data. Methods in Molecular Biology (Clifton, N.J.). 2051: 407-435. PMID 31552640 DOI: 10.1007/978-1-4939-9744-2_18  0.606
2019 Wang J, Su Y, Iacob RE, Engen JR, Springer TA. General structural features that regulate integrin affinity revealed by atypical αVβ8. Nature Communications. 10: 5481. PMID 31792290 DOI: 10.1038/S41467-019-13248-5  0.337
2019 Amatya N, Wales TE, Kwon A, Yeung W, Joseph RE, Fulton DB, Kannan N, Engen JR, Andreotti AH. Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591208 DOI: 10.1073/Pnas.1907566116  0.682
2019 Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nature Biotechnology. PMID 31427820 DOI: 10.1038/S41587-019-0222-Z  0.61
2019 Bera AK, Lu J, Wales TE, Gondi S, Gurbani D, Nelson A, Engen JR, Westover KD. Structural basis of the atypical activation mechanism of KRAS V14I. The Journal of Biological Chemistry. PMID 31341022 DOI: 10.1074/Jbc.Ra119.009131  0.666
2019 Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, et al. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nature Methods. 16: 595-602. PMID 31249422 DOI: 10.1038/S41592-019-0459-Y  0.749
2019 Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science (New York, N.Y.). PMID 31249135 DOI: 10.1126/science.aax1033  0.644
2019 Georgescauld F, Wales TE, Engen JR. Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding. Expert Review of Proteomics. 1-13. PMID 31215268 DOI: 10.1080/14789450.2019.1633920  0.695
2019 Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, ... ... Engen JR, et al. Tissue-specific oncogenic activity of K-RasA146T. Cancer Discovery. PMID 30952657 DOI: 10.1158/2159-8290.Cd-18-1220  0.61
2019 Kochert BA, Fleischhacker AS, Wales TE, Becker DF, Engen JR, Ragsdale SW. Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions. The Journal of Biological Chemistry. PMID 30944174 DOI: 10.1074/Jbc.Ra119.008592  0.803
2019 Dautant A, Henri J, Wales TE, Meyer P, Engen JR, Georgescauld F. Remodeling of the binding site of nucleoside diphosphate kinase revealed by X-Ray structure and H/D exchange. Biochemistry. PMID 30785730 DOI: 10.1021/Acs.Biochem.8B01308  0.667
2018 Shen K, Moroco JA, Patel RK, Shi H, Engen JR, Dorman HR, Smithgall TE. The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation. Science Signaling. 11. PMID 30352950 DOI: 10.1126/Scisignal.Aat5916  0.383
2018 Feng J, Dong X, Pinello J, Zhang J, Lu C, Iacob RE, Engen JR, Snell WJ, Springer TA. Fusion surface structure, function, and dynamics of gamete fusogen HAP2. Elife. 7. PMID 30281023 DOI: 10.7554/Elife.39772  0.308
2018 Wilson CJ, Das M, Jayaraman S, Gursky O, Engen JR. Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry. PMID 30004693 DOI: 10.1021/Acs.Biochem.8B00538  0.594
2018 Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA. Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nature Structural & Molecular Biology. PMID 29967539 DOI: 10.1038/S41594-018-0085-X  0.659
2018 de Wispelaere M, Lian W, Potisopon S, Li PC, Jang J, Ficarro SB, Clark MJ, Zhu X, Kaplan JB, Pitts JD, Wales TE, Wang J, Engen JR, Marto JA, Gray NS, et al. Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chemical Biology. PMID 29937406 DOI: 10.1016/J.Chembiol.2018.05.011  0.633
2018 Kochert BA, Iacob RE, Wales TE, Makriyannis A, Engen JR. Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes. Methods in Molecular Biology (Clifton, N.J.). 1764: 153-171. PMID 29605914 DOI: 10.1007/978-1-4939-7759-8_10  0.806
2018 Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, et al. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Molecular Cell. 69: 729-743.e7. PMID 29499131 DOI: 10.1016/J.Molcel.2018.02.005  0.625
2017 Moroco JA, Alvarado JJ, Staudt RP, Shic H, Wales TE, Smithgall TE, Engen JR. Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding. Journal of Molecular Biology. PMID 29258818 DOI: 10.1016/J.Jmb.2017.12.008  0.717
2017 Lamberto I, Liu X, Seo HS, Schauer NJ, Iacob RE, Hu W, Das D, Mikhailova T, Weisberg EL, Engen JR, Anderson KC, Chauhan D, Dhe-Paganon S, Buhrlage SJ. Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7. Cell Chemical Biology. PMID 29056421 DOI: 10.1016/J.Chembiol.2017.09.003  0.343
2017 Kerres N, Steurer S, Schlager S, Bader G, Berger H, Caligiuri M, Dank C, Engen JR, Ettmayer P, Fischerauer B, Flotzinger G, Gerlach D, Gerstberger T, Gmaschitz T, Greb P, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Reports. 20: 2860-2875. PMID 28930682 DOI: 10.1016/J.Celrep.2017.08.081  0.301
2017 Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH. Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts. Structure (London, England : 1993). PMID 28867612 DOI: 10.1016/J.Str.2017.07.014  0.699
2017 Bhat JY, Miličić G, Thieulin-Pardo G, Bracher A, Maxwell A, Ciniawsky S, Mueller-Cajar O, Engen JR, Hartl FU, Wendler P, Hayer-Hartl M. Mechanism of Enzyme Repair by the AAA(+) Chaperone Rubisco Activase. Molecular Cell. PMID 28803776 DOI: 10.1016/J.Molcel.2017.07.004  0.371
2017 Lu J, Harrison RA, Li L, Zeng M, Gondi S, Scott D, Gray NS, Engen JR, Westover KD. KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry. Structure (London, England : 1993). PMID 28781083 DOI: 10.1016/J.Str.2017.07.003  0.802
2017 Chen TF, Sazinsky SL, Houde D, DiLillo DJ, Bird J, Li KK, Cheng GT, Qiu H, Engen JR, Ravetch JV, Wittrup KD. Engineering Aglycosylated IgG Variants with Wild-type or Improved Binding Affinity to Human Fc gamma RIIA and Fc gamma RIIIAs. Journal of Molecular Biology. PMID 28694069 DOI: 10.1016/J.Jmb.2017.07.001  0.622
2017 Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Allosteric sensitization of proapoptotic BAX. Nature Chemical Biology. PMID 28692068 DOI: 10.1038/Nchembio.2433  0.642
2017 Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S. Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly. Structure (London, England : 1993). PMID 28648608 DOI: 10.1016/J.Str.2017.05.020  0.762
2017 Wales TE, Fadgen KE, Eggertson MJ, Engen JR. Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry. Journal of Chromatography. A. PMID 28596009 DOI: 10.1016/J.Chroma.2017.05.067  0.647
2017 Shen K, Dorman HR, Shi H, Patel RK, Moroco JA, Engen JR, Smithgall TE. Abstract 2377: The AML linked Src family kinase Fgr is uncoupled from SH2 and SH3 domain regulation and drives oncogenic transformation Cancer Research. 77: 2377-2377. DOI: 10.1158/1538-7445.Am2017-2377  0.327
2016 Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic? Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-2. PMID 28042708 DOI: 10.1080/13506129.2016.1269737  0.712
2016 Harrison RA, Lu J, Carrasco M, Hunter J, Manandhar A, Gondi S, Westover KD, Engen JR. Structural dynamics in Ras and related proteins upon nucleotide switching. Journal of Molecular Biology. PMID 27751724 DOI: 10.1016/J.Jmb.2016.10.017  0.788
2016 Harrison RA, Engen JR. Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry. Current Opinion in Structural Biology. 41: 187-193. PMID 27552080 DOI: 10.1016/J.Sbi.2016.08.003  0.809
2016 Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G. Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 27527097 DOI: 10.1007/S13361-016-1452-7  0.421
2016 Badger J, Grover P, Panjarian SB, Engen JR, Smithgall TE, Makowski L. The c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution. Biochemistry. PMID 27166638 DOI: 10.1021/Acs.Biochem.6B00202  0.427
2016 Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Allosteric inhibition of antiapoptotic MCL-1. Nature Structural & Molecular Biology. PMID 27159560 DOI: 10.1038/Nsmb.3223  0.653
2016 Wales TE, Poe JA, Emert-Sedlak L, Morgan CR, Smithgall TE, Engen JR. Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants. Journal of the American Society For Mass Spectrometry. PMID 27032648 DOI: 10.1007/S13361-016-1365-5  0.775
2016 Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH. Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases. Plos Computational Biology. 12: e1004826. PMID 27010561 DOI: 10.1371/Journal.Pcbi.1004826  0.686
2016 Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, et al. Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome. Science (New York, N.Y.). 351. PMID 26912900 DOI: 10.1126/Science.Aad9421  0.324
2016 Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK. Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis. Journal of the American Society For Mass Spectrometry. PMID 26810432 DOI: 10.1007/S13361-015-1330-8  0.644
2016 Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE. Dynamics of the Tec-family Tyrosine Kinase SH3 domains. Protein Science : a Publication of the Protein Society. PMID 26808198 DOI: 10.1002/Pro.2887  0.707
2016 Lee S, Wales TE, Gallagher C, Cohen DT, Escudero S, Luccarelli J, Huhn AJ, Cohen NA, Bird GH, Engen JR, Walensky LD. Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1 Cancer Research. 76: 3553-3553. DOI: 10.1158/1538-7445.Am2016-3553  0.66
2015 Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? Journal of Molecular Biology. PMID 26562506 DOI: 10.1016/J.Jmb.2015.10.029  0.754
2015 Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR. Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor. Biochemistry. 54: 6382-91. PMID 26440750 DOI: 10.1021/Acs.Biochem.5B00875  0.811
2015 Pirrone GF, Vernon BC, Kent MS, Engen JR. Hydrogen Exchange Mass Spectrometry of Proteins at Langmuir Monolayers. Analytical Chemistry. PMID 26134943 DOI: 10.1021/Acs.Analchem.5B01724  0.794
2015 Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR. Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer. Analytical Chemistry. PMID 26133569 DOI: 10.1021/Acs.Analchem.5B01725  0.809
2015 Engen JR, Wales TE. Analytical Aspects of Hydrogen Exchange Mass Spectrometry. Annual Review of Analytical Chemistry (Palo Alto, Calif.). PMID 26048552 DOI: 10.1146/Annurev-Anchem-062011-143113  0.651
2015 Marcsisin SR, Liptak C, Marineau J, Bradner JE, Engen JR. Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe. Analytical Chemistry. 87: 6349-56. PMID 26023704 DOI: 10.1021/Acs.Analchem.5B01220  0.771
2015 Black WA, Stocks BB, Mellors JS, Engen JR, Ramsey JM. Utilizing Microchip Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry. Analytical Chemistry. 87: 6280-7. PMID 25992468 DOI: 10.1021/Acs.Analchem.5B01179  0.333
2015 Iacob RE, Krystek SR, Huang RY, Wei H, Tao L, Lin Z, Morin PE, Doyle ML, Tymiak AA, Engen JR, Chen G. Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics. Expert Review of Proteomics. 12: 159-69. PMID 25711416 DOI: 10.1586/14789450.2015.1018897  0.328
2015 Nevin P, Engen JR, Beuning PJ. Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change. Dna Repair. 29: 65-73. PMID 25684709 DOI: 10.1016/J.Dnarep.2015.01.012  0.338
2015 Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Molecular Cell. 57: 873-86. PMID 25684204 DOI: 10.1016/J.Molcel.2015.01.014  0.65
2015 Pirrone GF, Iacob RE, Engen JR. Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Analytical Chemistry. 87: 99-118. PMID 25398026 DOI: 10.1021/Ac5040242  0.761
2015 Kent MS, Akgun B, Nanda H, Pirrone GF, Engen J. Combining Neutron Reflectivity and Hydrogen Deuterium Exchange Mass Spectrometry to Resolve Structural details of Membrane Associated Proteins Biophysical Journal. 108: 16a. DOI: 10.1016/J.Bpj.2014.11.112  0.8
2014 Iacob RE, Chen G, Ahn J, Houel S, Wei H, Mo J, Tao L, Cohen D, Xie D, Lin Z, Morin PE, Doyle ML, Tymiak AA, Engen JR. The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor. Journal of the American Society For Mass Spectrometry. 25: 2093-102. PMID 25223306 DOI: 10.1007/S13361-014-0973-1  0.637
2014 Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH. A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. Journal of Molecular Biology. 426: 3656-69. PMID 25193673 DOI: 10.1016/J.Jmb.2014.08.018  0.662
2014 Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE. Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. Plos One. 9: e105629. PMID 25144189 DOI: 10.1371/Journal.Pone.0105629  0.683
2014 Wang W, Iacob RE, Luoh RP, Engen JR, Lippard SJ. Electron transfer control in soluble methane monooxygenase. Journal of the American Chemical Society. 136: 9754-62. PMID 24937475 DOI: 10.1021/Ja504688Z  0.361
2014 Georgescauld F, Popova K, Gupta AJ, Bracher A, Engen JR, Hayer-Hartl M, Hartl FU. GroEL/ES chaperonin modulates the mechanism and accelerates the rate of TIM-barrel domain folding. Cell. 157: 922-34. PMID 24813614 DOI: 10.1016/J.Cell.2014.03.038  0.404
2014 Fang J, Nevin P, Kairys V, Venclovas C, Engen JR, Beuning PJ. Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics. Structure (London, England : 1993). 22: 572-81. PMID 24613485 DOI: 10.1016/J.Str.2014.02.001  0.397
2014 Parker CH, Morgan CR, Rand KD, Engen JR, Jorgenson JW, Stafford DW. A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry. Biochemistry. 53: 1511-20. PMID 24512177 DOI: 10.1021/Bi401536M  0.675
2014 Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Jänne PA, Meyerson M, Marto JA, Engen JR, et al. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angewandte Chemie (International Ed. in English). 53: 199-204. PMID 24259466 DOI: 10.1002/Anie.201307387  0.766
2014 Wei H, Mo J, Tao L, Russell RJ, Tymiak AA, Chen G, Iacob RE, Engen JR. Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications. Drug Discovery Today. 19: 95-102. PMID 23928097 DOI: 10.1016/J.Drudis.2013.07.019  0.415
2013 Shi XE, Wales TE, Elkin C, Kawahata N, Engen JR, Annis DA. Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties. Analytical Chemistry. 85: 11185-8. PMID 24215480 DOI: 10.1021/Ac403173P  0.656
2013 Iacob RE, Bou-Assaf GM, Makowski L, Engen JR, Berkowitz SA, Houde D. Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements. Journal of Pharmaceutical Sciences. 102: 4315-29. PMID 24136070 DOI: 10.1002/Jps.23754  0.629
2013 Akgun B, Satija S, Nanda H, Pirrone GF, Shi X, Engen JR, Kent MS. Conformational transition of membrane-associated terminally acylated HIV-1 Nef. Structure (London, England : 1993). 21: 1822-33. PMID 24035710 DOI: 10.1016/J.Str.2013.08.008  0.779
2013 Guttman M, Weis DD, Engen JR, Lee KK. Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectra. Journal of the American Society For Mass Spectrometry. 24: 1906-12. PMID 24018862 DOI: 10.1007/S13361-013-0727-5  0.343
2013 Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH. Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Science Signaling. 6: ra76. PMID 23982207 DOI: 10.1126/Scisignal.2004298  0.654
2013 Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A. Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry. 52: 5016-26. PMID 23795559 DOI: 10.1021/Bi400430K  0.692
2013 Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. Journal of Molecular Biology. 425: 3192-204. PMID 23747483 DOI: 10.1016/J.Jmb.2013.05.025  0.653
2013 Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O. Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI). The Journal of Biological Chemistry. 288: 19845-60. PMID 23720744 DOI: 10.1074/Jbc.M113.460170  0.679
2013 Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE. Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry. International Reviews in Physical Chemistry. 32: 96-127. PMID 23682200 DOI: 10.1080/0144235X.2012.751175  0.759
2013 Wales TE, Eggertson MJ, Engen JR. Considerations in the analysis of hydrogen exchange mass spectrometry data. Methods in Molecular Biology (Clifton, N.J.). 1007: 263-88. PMID 23666730 DOI: 10.1007/978-1-62703-392-3_11  0.639
2013 Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A. Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Science : a Publication of the Protein Society. 22: 774-87. PMID 23553709 DOI: 10.1002/Pro.2257  0.678
2013 Houde D, Engen JR. Conformational analysis of recombinant monoclonal antibodies with hydrogen/deuterium exchange mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 988: 269-89. PMID 23475726 DOI: 10.1007/978-1-62703-327-5_17  0.653
2013 Panjarian S, Iacob RE, Chen S, Engen JR, Smithgall TE. Structure and dynamic regulation of Abl kinases. The Journal of Biological Chemistry. 288: 5443-50. PMID 23316053 DOI: 10.1074/Jbc.R112.438382  0.543
2013 Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE. Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. The Journal of Biological Chemistry. 288: 6116-29. PMID 23303187 DOI: 10.1074/Jbc.M112.431312  0.737
2013 Ahn J, Cao MJ, Yu YQ, Engen JR. Accessing the reproducibility and specificity of pepsin and other aspartic proteases. Biochimica Et Biophysica Acta. 1834: 1222-9. PMID 23063535 DOI: 10.1016/J.Bbapap.2012.10.003  0.61
2013 Panjarian SB, Iacob R, Shugui C, Wales T, Engen JR, Smithgall TE. Abstract 2221: Enhanced SH3:linker interaction allosterically sensitizes Abl kinases to small molecule inhibitors. Cancer Research. 73: 2221-2221. DOI: 10.1158/1538-7445.Am2013-2221  0.692
2013 Kent MS, Akgun B, Satija S, Nanda H, Vernon BC, Shi X, Pirrone GF, Engen JR. The Conformation of Membrane-Associated HIV Nef and its Interactions with Hck Biophysical Journal. 104: 64a. DOI: 10.1016/J.Bpj.2012.11.391  0.787
2013 Beuning PJ, Fang J, Nevin P, Engen JR. Conformational Analysis of Processivity Clamps Demonstrates that Protein Tertiary Structure Does Not Correlate with Dynamics Biophysical Journal. 104: 29a. DOI: 10.1016/J.Bpj.2012.11.198  0.421
2013 Ahn J, Engen JR. The use of hydrogen/deuterium exchange mass spectrometry in epitope mapping Chimica Oggi/Chemistry Today. 31: 25-28.  0.506
2012 Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nature Communications. 3: 1288. PMID 23250418 DOI: 10.1038/Ncomms2304  0.367
2012 Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A. Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). Acs Chemical Neuroscience. 3: 393-9. PMID 22860208 DOI: 10.1021/Cn3000263  0.651
2012 Ahn J, Jung MC, Wyndham K, Yu YQ, Engen JR. Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi. Analytical Chemistry. 84: 7256-62. PMID 22856522 DOI: 10.1021/Ac301749H  0.53
2012 Berkowitz SA, Engen JR, Mazzeo JR, Jones GB. Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nature Reviews. Drug Discovery. 11: 527-40. PMID 22743980 DOI: 10.1038/Nrd3746  0.31
2012 Iacob RE, Engen JR. Hydrogen exchange mass spectrometry: are we out of the quicksand? Journal of the American Society For Mass Spectrometry. 23: 1003-10. PMID 22476891 DOI: 10.1007/S13361-012-0377-Z  0.414
2012 Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE. HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. Bmc Chemical Biology. 12: 1. PMID 22420777 DOI: 10.1186/1472-6769-12-1  0.678
2012 Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC. Conformational locking upon cooperative assembly of notch transcription complexes. Structure (London, England : 1993). 20: 340-9. PMID 22325781 DOI: 10.1016/J.Str.2011.12.011  0.658
2012 Wei H, Ahn J, Yu YQ, Tymiak A, Engen JR, Chen G. Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation. Journal of the American Society For Mass Spectrometry. 23: 498-504. PMID 22227798 DOI: 10.1007/S13361-011-0310-X  0.61
2012 Panjarian SB, Chen S, Iacob R, Wales T, Engen JR, Smithgall TE. Abstract 5599: Allosteric regulation of Abl and Bcr-Abl kinases by enhanced SH3:linker interaction Cancer Research. 72: 5599-5599. DOI: 10.1158/1538-7445.Am2012-5599  0.744
2012 Kent MS, Akgun B, Nanda H, Curtis JE, Satija S, Shi X, Engen JR. Conformational Change of HIV Nef upon Insertion into Lipid Membranes Resolved by Neutron Reflectivity Biophysical Journal. 102: 26a. DOI: 10.1016/J.Bpj.2011.11.166  0.391
2011 Kim M, Sun ZY, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang JH, Engen JR, Wagner G, Reinherz EL. Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nature Structural & Molecular Biology. 18: 1235-43. PMID 22002224 DOI: 10.1038/Nsmb.2154  0.345
2011 Marcsisin SR, Narute PS, Emert-Sedlak LA, Kloczewiak M, Smithgall TE, Engen JR. On the solution conformation and dynamics of the HIV-1 viral infectivity factor. Journal of Molecular Biology. 410: 1008-22. PMID 21763503 DOI: 10.1016/J.Jmb.2011.04.053  0.775
2011 Morgan CR, Hebling CM, Rand KD, Stafford DW, Jorgenson JW, Engen JR. Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs. Molecular & Cellular Proteomics : McP. 10: M111.010876. PMID 21715319 DOI: 10.1074/Mcp.M111.010876  0.652
2011 Fang J, Engen JR, Beuning PJ. Escherichia coli processivity clamp β from DNA polymerase III is dynamic in solution. Biochemistry. 50: 5958-68. PMID 21657794 DOI: 10.1021/Bi200580B  0.378
2011 Fang J, Rand KD, Beuning PJ, Engen JR. False EX1 signatures caused by sample carryover during HX MS analyses. International Journal of Mass Spectrometry. 302: 19-25. PMID 21643454 DOI: 10.1016/J.Ijms.2010.06.039  0.398
2011 Houde D, Berkowitz SA, Engen JR. The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies. Journal of Pharmaceutical Sciences. 100: 2071-86. PMID 21491437 DOI: 10.1002/Jps.22432  0.671
2011 Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (London, England : 1993). 19: 546-54. PMID 21481777 DOI: 10.1016/J.Str.2011.01.016  0.653
2011 Morgan CR, Miglionico BV, Engen JR. Effects of HIV-1 Nef on human N-myristoyltransferase 1. Biochemistry. 50: 3394-403. PMID 21449607 DOI: 10.1021/Bi200197E  0.636
2011 Iacob RE, Zhang J, Gray NS, Engen JR. Allosteric interactions between the myristate- and ATP-site of the Abl kinase. Plos One. 6: e15929. PMID 21264348 DOI: 10.1371/Journal.Pone.0015929  0.392
2011 Panjarian SB, Chen S, Iacob R, Wales TE, Engen JR, Smithgall TE. Abstract B75: Allosteric regulation of Abl and Bcr-Abl kinases by enhanced SH3:linker interaction. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B75  0.747
2011 Kent MS, Murton JK, Satija S, Akgun B, Nanda H, Curtis JE, Majewski J, Engen JR, Morgan CR. The Conformation and Activity of Membane-Bound HIV Nef Studied by Neutron Reflectivity Biophysical Journal. 100: 374a. DOI: 10.1016/J.Bpj.2010.12.2228  0.642
2010 Kent MS, Murton JK, Sasaki DY, Satija S, Akgun B, Nanda H, Curtis JE, Majewski J, Morgan CR, Engen JR. Neutron reflectometry study of the conformation of HIV Nef bound to lipid membranes. Biophysical Journal. 99: 1940-8. PMID 20858440 DOI: 10.1016/J.Bpj.2010.07.016  0.632
2010 Marcsisin SR, Engen JR. Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif. Journal of Molecular Biology. 402: 892-904. PMID 20728451 DOI: 10.1016/J.Jmb.2010.08.026  0.763
2010 Hebling CM, Morgan CR, Stafford DW, Jorgenson JW, Rand KD, Engen JR. Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry. Analytical Chemistry. 82: 5415-9. PMID 20518534 DOI: 10.1021/Ac100962C  0.636
2010 Fang J, Rand KD, Silva MC, Wales TE, Engen JR, Beuning PJ. Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'. Journal of Molecular Biology. 398: 40-53. PMID 20206636 DOI: 10.1016/J.Jmb.2010.02.040  0.663
2010 Marcsisin SR, Engen JR. Hydrogen exchange mass spectrometry: what is it and what can it tell us? Analytical and Bioanalytical Chemistry. 397: 967-72. PMID 20195578 DOI: 10.1007/S00216-010-3556-4  0.77
2010 Houde D, Peng Y, Berkowitz SA, Engen JR. Post-translational modifications differentially affect IgG1 conformation and receptor binding. Molecular & Cellular Proteomics : McP. 9: 1716-28. PMID 20103567 DOI: 10.1074/Mcp.M900540-Mcp200  0.672
2010 Zhang J, Adrián FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, ... ... Engen JR, et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 463: 501-6. PMID 20072125 DOI: 10.1038/Nature08675  0.357
2010 Panjarian S, Chen S, Engen J, Smithgall T. Enhanced SH3:Linker Interaction Suppresses Activating Mutations of the c-Abl Protein-Tyrosine Kinase. Blood. 116: 1208-1208. DOI: 10.1182/Blood.V116.21.1208.1208  0.602
2010 Beuning PJ, Fang J, Sefcikova J, Silva MC, Engen JR. The Dynamic DNA Damage Inducible Protein UmuD Inhibits Replication Biophysical Journal. 98: 64a. DOI: 10.1016/J.Bpj.2009.12.363  0.317
2010 Kent MS, Murton JK, Satija S, Akgun B, Nanda H, Curtis J, Majewski J, Morgan C, Engen JR. A Study of the Conformation of HIV Nef Bound to Lipid Membranes by Neutron Reflectivity Biophysical Journal. 98: 233a. DOI: 10.1016/J.Bpj.2009.12.1259  0.62
2009 Morgan CR, Engen JR. Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 17.6.1-17. PMID 19937720 DOI: 10.1002/0471140864.Ps1706S58  0.645
2009 Rand KD, Pringle SD, Murphy JP, Fadgen KE, Brown J, Engen JR. Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations. Analytical Chemistry. 81: 10019-28. PMID 19921790 DOI: 10.1021/Ac901897X  0.332
2009 Engen JR. Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS. Analytical Chemistry. 81: 7870-5. PMID 19788312 DOI: 10.1021/Ac901154S  0.399
2009 Houde D, Arndt J, Domeier W, Berkowitz S, Engen JR. Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical Chemistry. 81: 5966. PMID 19606834 DOI: 10.1021/ac9009287  0.626
2009 Houde D, Arndt J, Domeier W, Berkowitz S, Engen JR. Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Analytical Chemistry. 81: 2644-51. PMID 19265386 DOI: 10.1021/Ac802575Y  0.679
2009 Iacob RE, Pene-Dumitrescu T, Zhang J, Gray NS, Smithgall TE, Engen JR. Conformational disturbance in Abl kinase upon mutation and deregulation. Proceedings of the National Academy of Sciences of the United States of America. 106: 1386-91. PMID 19164531 DOI: 10.1073/Pnas.0811912106  0.472
2009 Chen S, Engen JR. Isotope exchange and covalent modification strategies for studying protein structure and function Current Analytical Chemistry. 5: 205-212. DOI: 10.2174/157341109787846144  0.489
2009 Zhang J, Gray NS, Sim T, Choi Y, Deng X, Adrián F, Li A, Sun F, Liu Y, Okram B, Warmuth M, Iacob R, Engen J, Powers J, Azam M, et al. Abstract B165: Abl kinase myristate‐site inhibitor, mechanism and application Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B165  0.342
2009 Houde D, Engen JR. Conformational dynamics of proteins By mass spectrometry hydrogen/deuterium exchange and covalent labelling approaches Chimica Oggi. 27: XII-XV.  0.634
2008 Chen S, O'Reilly LP, Smithgall TE, Engen JR. Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. Journal of Molecular Biology. 383: 414-23. PMID 18775435 DOI: 10.1016/J.Jmb.2008.08.040  0.599
2008 Iacob RE, Murphy JP, Engen JR. Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange. Rapid Communications in Mass Spectrometry : Rcm. 22: 2898-904. PMID 18727141 DOI: 10.1002/Rcm.3688  0.329
2008 Wales TE, Fadgen KE, Gerhardt GC, Engen JR. High-speed and high-resolution UPLC separation at zero degrees Celsius. Analytical Chemistry. 80: 6815-20. PMID 18672890 DOI: 10.1021/Ac8008862  0.651
2008 Engen JR, Wales TE, Hochrein JM, Meyn MA, Banu Ozkan S, Bahar I, Smithgall TE. Structure and dynamic regulation of Src-family kinases. Cellular and Molecular Life Sciences : Cmls. 65: 3058-73. PMID 18563293 DOI: 10.1007/S00018-008-8122-2  0.794
2008 Chen S, Dumitrescu TP, Smithgall TE, Engen JR. Abl N-terminal cap stabilization of SH3 domain dynamics. Biochemistry. 47: 5795-803. PMID 18452309 DOI: 10.1021/Bi800446B  0.585
2008 Mitchell JL, Engen JR. Chapter 4 Protein Analysis with Hydrogen-Deuterium Exchange Mass Spectrometry Comprehensive Analytical Chemistry. 52: 83-102. DOI: 10.1016/S0166-526X(08)00204-3  0.436
2007 Brier S, Maria G, Carginale V, Capasso A, Wu Y, Taylor RM, Borotto NB, Capasso C, Engen JR. Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii. The Febs Journal. 274: 6152-66. PMID 17976195 DOI: 10.1111/J.1742-4658.2007.06136.X  0.331
2007 Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE. Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. Journal of Molecular Biology. 374: 121-9. PMID 17920628 DOI: 10.1016/J.Jmb.2007.09.009  0.672
2007 Chen S, Brier S, Smithgall TE, Engen JR. The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding. Protein Science : a Publication of the Protein Society. 16: 572-81. PMID 17327393 DOI: 10.1110/Ps.062631007  0.59
2007 Mitchell JL, Trible RP, Emert-Sedlak LA, Weis DD, Lerner EC, Applen JJ, Sefton BM, Smithgall TE, Engen JR. Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein. Journal of Molecular Biology. 366: 1282-93. PMID 17207813 DOI: 10.1016/J.Jmb.2006.12.026  0.454
2006 Weis DD, Kjellen P, Sefton BM, Engen JR. Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip. Protein Science : a Publication of the Protein Society. 15: 2402-10. PMID 17008721 DOI: 10.1110/Ps.052016406  0.431
2006 Meyn MA, Wilson MB, Abdi FA, Fahey N, Schiavone AP, Wu J, Hochrein JM, Engen JR, Smithgall TE. Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. The Journal of Biological Chemistry. 281: 30907-16. PMID 16912036 DOI: 10.1074/Jbc.M605902200  0.77
2006 Weis DD, Wales TE, Engen JR, Hotchko M, Ten Eyck LF. Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. Journal of the American Society For Mass Spectrometry. 17: 1498-509. PMID 16875839 DOI: 10.1016/J.Jasms.2006.05.014  0.659
2006 Hochrein JM, Wales TE, Lerner EC, Schiavone AP, Smithgall TE, Engen JR. Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry. Biochemistry. 45: 7733-9. PMID 16784224 DOI: 10.1021/Bi060438X  0.801
2006 Kaveti S, Engen JR. Protein interactions probed with mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 316: 179-97. PMID 16671405 DOI: 10.1385/1-59259-964-8:179  0.429
2006 Wu Y, Kaveti S, Engen JR. Extensive deuterium back-exchange in certain immobilized pepsin columns used for H/D exchange mass spectrometry. Analytical Chemistry. 78: 1719-23. PMID 16503628 DOI: 10.1021/Ac0518497  0.423
2006 Wales TE, Engen JR. Partial unfolding of diverse SH3 domains on a wide timescale. Journal of Molecular Biology. 357: 1592-604. PMID 16487539 DOI: 10.1016/J.Jmb.2006.01.075  0.68
2006 Wu Y, Engen JR, Hobbins WB. Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry. Journal of the American Society For Mass Spectrometry. 17: 163-7. PMID 16406808 DOI: 10.1016/J.Jasms.2005.10.009  0.414
2006 Hochrein JM, Lerner EC, Schiavone AP, Smithgall TE, Engen JR. An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry. Protein Science : a Publication of the Protein Society. 15: 65-73. PMID 16322569 DOI: 10.1110/Ps.051782206  0.798
2006 Wales TE, Engen JR. Hydrogen exchange mass spectrometry for the analysis of protein dynamics. Mass Spectrometry Reviews. 25: 158-70. PMID 16208684 DOI: 10.1002/Mas.20064  0.694
2006 Kaltashov IA, Engen JR, Gross ML. Hydrogen Exchange and Covalent Modification: Focus on Biomolecular Structure, Dynamics, and Function. 18th Sanibel Conference on Mass Spectrometry Journal of the American Society For Mass Spectrometry. 17: I1-I2. DOI: 10.1016/J.Jasms.2006.08.005  0.363
2005 Lu X, Li L, Feng X, Wu Y, Dunaway-Mariano D, Engen JR, Mariano PS. L-canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase. Journal of the American Chemical Society. 127: 16412-3. PMID 16305225 DOI: 10.1021/Ja056226P  0.352
2005 Lerner EC, Trible RP, Schiavone AP, Hochrein JM, Engen JR, Smithgall TE. Activation of the Src family kinase Hck without SH3-linker release. The Journal of Biological Chemistry. 280: 40832-7. PMID 16210316 DOI: 10.1074/Jbc.M508782200  0.78
2005 Carter JM, Gurevich VV, Prossnitz ER, Engen JR. Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry. Journal of Molecular Biology. 351: 865-78. PMID 16045931 DOI: 10.1016/J.Jmb.2005.06.048  0.424
2004 Wu Y, Engen JR. What mass spectrometry can reveal about protein function. The Analyst. 129: 290-6. PMID 15042158 DOI: 10.1039/B316341E  0.442
2003 Engen JR. Analysis of protein complexes with hydrogen exchange and mass spectrometry. The Analyst. 128: 623-8. PMID 12866878 DOI: 10.1039/B212800B  0.434
2003 Takashima Y, Delfino FJ, Engen JR, Superti-Furga G, Smithgall TE. Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae. Biochemistry. 42: 3567-74. PMID 12653561 DOI: 10.1021/Bi0272499  0.355
2002 Harris MN, Burchiel SW, Winyard PG, Engen JR, Mobarak CD, Timmins GS. Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry. Chemical Research in Toxicology. 15: 1589-94. PMID 12482241 DOI: 10.1021/Tx025594T  0.34
2002 Engen JR, Bradbury EM, Chen X. Using stable-isotope-labeled proteins for hydrogen exchange studies in complex mixtures. Analytical Chemistry. 74: 1680-6. PMID 12033260 DOI: 10.1021/Ac011122S  0.381
2001 Gmeiner WH, Xu I, Horita DA, Smithgall TE, Engen JR, Smith DL, Byrd RA. Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP. Cell Biochemistry and Biophysics. 35: 115-26. PMID 11892787 DOI: 10.1385/Cbb:35:2:115  0.555
2001 Dorey K, Engen JR, Kretzschmar J, Wilm M, Neubauer G, Schindler T, Superti-Furga G. Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase. Oncogene. 20: 8075-84. PMID 11781820 DOI: 10.1038/Sj.Onc.1205017  0.356
2001 Engen JR, Smith DL. Investigating protein structure and dynamics by hydrogen exchange MS. Analytical Chemistry. 73: 256A-265A. PMID 11354508 DOI: 10.1021/Ac012452F  0.512
2000 Engen JR, Smith DL. Investigating the higher order structure of proteins. Hydrogen exchange, proteolytic fragmentation, and mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 146: 95-112. PMID 10948498 DOI: 10.1385/1-59259-045-4:95  0.507
1999 Engen JR, Gmeiner WH, Smithgall TE, Smith DL. Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2. Biochemistry. 38: 8926-35. PMID 10413466 DOI: 10.1021/Bi982611Y  0.55
1999 Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation. Journal of Molecular Biology. 287: 645-56. PMID 10092465 DOI: 10.1006/Jmbi.1999.2619  0.527
1997 Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry. Biochemistry. 36: 14384-91. PMID 9398156 DOI: 10.1021/Bi971635M  0.588
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