Mark W. Hochstrasser
Affiliations: | Molecular Biophysics and Biochemistry | Yale University, New Haven, CT |
Area:
Protein degradation, ubiquitinWebsite:
http://medicine.yale.edu/mbb/faculty/mark_hochstrasser.profileGoogle:
"Mark W. Hochstrasser"Bio:
Mark Hochstrasser received his bachelor’s degree in 1981 from Rutgers University, where he majored in biochemistry. For his Ph.D. studies, he worked with Dr. John Sedat at the University of California, San Francisco on the three-dimensional organization of chromosomes. He did postdoctoral research with Dr. Alexander Varshavsky at the Massachusetts Institute of Technology, where he began studying mechanisms of intracellular protein degradation. In 1990 he took a faculty position at the University of Chicago. Since 2000, he has been a professor at Yale University, and in 2008 he was named the Eugene Higgins Professor of Molecular Biophysics & Biochemistry. Research in the Hochstrasser lab centers on biochemical and genetic studies of the ubiquitin-proteasome system of protein degradation and related ubiquitin-like protein modification pathways, particularly the SUMO system.
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| John W. Sedat | grad student | 1987 | UCSF (Chemistry Tree) | |
| (Three-dimensional organization of interphase chromosomes in different polytene tissues of Drosophila melanogaster) | ||||
| Alexander Varshavsky | post-doc | 1990 | MIT | |
Children
Sign in to add trainee| Ping Chen | grad student | Chicago (Chemistry Tree) | |
| Feroz Papa | grad student | Chicago (Chemistry Tree) | |
| Sowmya Swaminathan | grad student | 2000 | Chicago (Chemistry Tree) |
| Cassandra S. Arendt | grad student | 2001 | Chicago (Chemistry Tree) |
| Robert J. Swanson | grad student | 2001 | Chicago (Chemistry Tree) |
| Alaron A. Lewis | grad student | 2006 | Yale (Chemistry Tree) |
| Mary B. Kroetz | grad student | 2008 | Yale (Chemistry Tree) |
| Yang Xie | grad student | 2009 | Yale (Chemistry Tree) |
| Rachael S. Felberbaum | grad student | 2011 | Yale (Chemistry Tree) |
| Mary J. Kunjappu | grad student | 2013 | Yale (Chemistry Tree) |
| Christopher M. Hickey | post-doc | 2010- | Yale |
| Judith A. Ronau | post-doc | 2014- | Yale (Chemistry Tree) |
| Eric M Rubenstein | post-doc | 2008-2012 | Yale |
| Robert J Tomko Jr | post-doc | 2008-2014 | Yale |
| Achuth Padmanabhan | post-doc | 2012-2015 | Yale (Chemistry Tree) |
Publications
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| Ruiz-Romero G, Berdún MD, Hochstrasser M, et al. (2024) Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity. Iscience. 27: 111095 |
| Breckel CA, Johnson ZM, Hickey CM, et al. (2024) Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1. Scientific Reports. 14: 2048 |
| Sultana S, Abdullah M, Li J, et al. (2023) Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast. Genetics |
| Li Y, Tomko RJ, Hochstrasser M. (2023) Proteasomes: Isolation and Activity Assays. Current Protocols. 3: e717 |
| Mehrtash AB, Hochstrasser M. (2023) Ectopic RING activity at the ER membrane differentially impacts ERAD protein quality control pathways. The Journal of Biological Chemistry. 102927 |
| Mehrtash AB, Hochstrasser M. (2022) Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets. Iscience. 25: 105351 |
| Zhang M, Berk JM, Mehrtash AB, et al. (2022) A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins. Plos Biology. 20: e3001501 |
| Li J, Hochstrasser M. (2022) Selective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation. Journal of Cell Science. 135 |
| Breckel CA, Hochstrasser M. (2021) Ubiquitin Ligase Redundancy and Nuclear-Cytoplasmic Localization in Yeast Protein Quality Control. Biomolecules. 11 |
| Cheng CL, Wong MK, Hochstrasser M. (2021) Yeast Nst1 is a Novel Component of P-bodies and is a Specific Suppressor of Proteasome Base Assembly Defects. Molecular Biology of the Cell. mbcE21040178 |