David A. Christian, Ph.D. - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
cell biophysics and polymer engineering

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Cohn IS, Wallbank BA, Haskins BE, O'Dea KM, Pardy RD, Shaw S, Merolle MI, Gullicksrud JA, Christian DA, Striepen B, Hunter CA. Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium. The Journal of Experimental Medicine. 221. PMID 38829369 DOI: 10.1084/jem.20232067  0.837
2024 Haskins BE, Gullicksrud JA, Wallbank BA, Dumaine JE, Guérin A, Cohn IS, O'Dea KM, Pardy RD, Merolle MI, Shallberg LA, Hunter EN, Byerly JH, Smith EJ, Buenconsejo GY, McLeod BI, ... Christian DA, et al. Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses. Mucosal Immunology. PMID 38508522 DOI: 10.1016/j.mucimm.2024.03.003  0.843
2023 Cohn IS, Wallbank BA, Haskins BE, O'Dea KM, Pardy RD, Shaw S, Merolle MI, Gullicksrud JA, Christian DA, Striepen B, Hunter CA. Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4 T cell-mediated resistance to . Biorxiv : the Preprint Server For Biology. PMID 38014026 DOI: 10.1101/2023.11.11.566669  0.84
2023 Haskins BE, Gullicksrud JA, Wallbank BA, Dumaine JE, Guérin A, Cohn IS, O'Dea KM, Pardy RD, Merolle MI, Shallberg LA, Hunter EN, Byerly JH, Smith EJ, Buenconsejo GY, McLeod BI, ... Christian DA, et al. Dendritic cell-mediated responses to secreted effectors are required for parasite-specific CD8 T cell responses. Biorxiv : the Preprint Server For Biology. PMID 37645924 DOI: 10.1101/2023.08.16.553566  0.842
2023 Pereira JA, Lanzar Z, Clark JT, Hart AP, Douglas BB, Shallberg L, O'Dea K, Christian DA, Hunter CA. PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis. Frontiers in Immunology. 14: 997376. PMID 36960049 DOI: 10.3389/fimmu.2023.997376  0.667
2022 Pritchard GH, Phan AT, Christian DA, Blain TJ, Fang Q, Johnson J, Roy NH, Shallberg L, Kedl RM, Hunter CA. Early T-bet promotes LFA1 upregulation required for CD8+ effector and memory T cell development. The Journal of Experimental Medicine. 220. PMID 36445307 DOI: 10.1084/jem.20191287  0.838
2022 Christian DA, Adams TA, Shallberg LA, Phan AT, Smith TE, Abraha M, Perry J, Ruthel G, Clark JT, Pritchard GH, Aronson LR, Gossa S, McGavern DB, Kedl RM, Hunter CA. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Science Immunology. 7: eabq7432. PMID 36179012 DOI: 10.1126/sciimmunol.abq7432  0.844
2022 Shallberg LA, Phan AT, Christian DA, Perry JA, Haskins BE, Beiting DP, Harris TH, Koshy AA, Hunter CA. Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis. Plos Pathogens. 18: e1010296. PMID 35727849 DOI: 10.1371/journal.ppat.1010296  0.769
2022 Perry JA, Shallberg L, Clark JT, Gullicksrud JA, DeLong JH, Douglas BB, Hart AP, Lanzar Z, O'Dea K, Konradt C, Park J, Kuchroo JR, Grubaugh D, Zaretsky AG, Brodsky IE, ... ... Christian DA, et al. PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology. PMID 35437326 DOI: 10.1038/s41590-022-01170-w  0.792
2021 Gullicksrud JA, Sateriale A, Engiles JB, Gibson AR, Shaw S, Hutchins ZA, Martin L, Christian DA, Taylor GA, Yamamoto M, Beiting DP, Striepen B, Hunter CA. Enterocyte-innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium. Mucosal Immunology. PMID 34750455 DOI: 10.1038/s41385-021-00468-6  0.79
2021 Lin CH, Chen MC, Lin LL, Christian DA, Min B, Hunter CA, Lu LF. Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes. The Journal of Experimental Medicine. 218. PMID 34554189 DOI: 10.1084/jem.20210021  0.511
2021 Clark JT, Christian DA, Gullicksrud JA, Perry JA, Park J, Jacquet M, Tarrant JC, Radaelli E, Silver J, Hunter CA. IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to . Elife. 10. PMID 33929319 DOI: 10.7554/eLife.65614  0.778
2021 Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Cummins KD, Lee YG, Pajarillo R, Chun I, Shyu A, Highfill SL, Price A, Zhao L, Peng L, ... ... Christian DA, et al. Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nature Medicine. PMID 33888899 DOI: 10.1038/s41591-021-01326-5  0.359
2020 Chen L, Christian DA, Kochanowsky JA, Phan AT, Clark JT, Wang S, Berry C, Oh J, Chen X, Roos DS, Beiting DP, Koshy AA, Hunter CA. The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses. The Journal of Experimental Medicine. 217. PMID 31961916 DOI: 10.1084/Jem.20181757  0.789
2019 Hung LY, Johnson JL, Ji Y, Christian DA, Herbine KR, Pastore CF, Herbert DR. Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 31175162 DOI: 10.4049/Jimmunol.1900363  0.424
2019 DeLaney AA, Berry CT, Christian DA, Hart A, Bjanes E, Wynosky-Dolfi MA, Li X, Tummers B, Udalova IA, Chen YH, Hershberg U, Freedman BD, Hunter CA, Brodsky IE. Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against . Proceedings of the National Academy of Sciences of the United States of America. PMID 31147458 DOI: 10.1073/Pnas.1820529116  0.523
2019 Wang S, El-Fahmawi A, Christian DA, Fang Q, Radaelli E, Chen L, Sullivan MC, Misic AM, Ellringer JA, Zhu XQ, Winter SE, Hunter CA, Beiting DP. Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production. Mbio. 10. PMID 31138751 DOI: 10.1128/Mbio.00935-19  0.722
2019 Singh N, Frey NV, Engels B, Barrett DM, Shestova O, Ravikumar P, Shyu A, Highfill S, Zhao L, Peng L, Granda B, Ramones M, Lu XM, Christian DA, Perazzelli J, et al. Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy Blood. 134: 247-247. DOI: 10.1182/Blood-2019-131024  0.467
2017 Mahmud A, Harada T, Rajagopal K, Christian DA, Nair P, Murphy R, Discher DE. Spray stability of self-assembled filaments for delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28549950 DOI: 10.1016/J.Jconrel.2017.05.026  0.756
2017 O'Brien CA, Overall C, Konradt C, O'Hara Hall AC, Hayes NW, Wagage S, John B, Christian DA, Hunter CA, Harris TH. CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 28389591 DOI: 10.4049/Jimmunol.1601581  0.81
2017 Muallem G, Wagage S, Sun Y, DeLong JH, Valenzuela A, Christian DA, Harms Pritchard G, Fang Q, Buza EL, Jain D, Elloso MM, López CB, Hunter CA. IL-27 LIMITS TYPE 2 IMMUNOPATHOLOGY FOLLOWING PARAINFLUENZA VIRUS INFECTION. Plos Pathogens. 13: e1006173. PMID 28129374 DOI: 10.1371/Journal.Ppat.1006173  0.805
2017 Ruella M, Maude SL, Engels B, Barrett DM, Frey N, Marcucci KT, Shestova O, Singh N, Perazzelli J, Christian DA, Haagen D, Lacey SF, Melenhorst JJ, Brogdon J, Young RM, et al. Clinical Efficacy of Anti-CD22 Chimeric Antigen Receptor T Cells for B-Cell Acute Lymphoblastic Leukemia Is Correlated with the Length of the Scfv Linker and Can be Predicted Using Xenograft Models Blood. 130: 807-807. DOI: 10.1182/Blood.V130.Suppl_1.807.807  0.416
2016 Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nature Microbiology. 1: 16001. PMID 27572166 DOI: 10.1038/Nmicrobiol.2016.1  0.781
2016 Ruella M, Barrett DM, Kenderian SS, Shestova O, Hofmann TJ, Perazzelli J, Klichinsky M, Aikawa V, Nazimuddin F, Kozlowski M, Scholler J, Lacey SF, Melenhorst JJ, Morrissette JJ, Christian DA, et al. Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies. The Journal of Clinical Investigation. PMID 27571406 DOI: 10.1172/Jci87366  0.554
2016 Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nature Microbiology. 1. PMID 27478622  0.303
2016 Weinkopff T, Konradt C, Christian DA, Discher DE, Hunter CA, Scott P. Leishmania major Infection-Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease. Journal of Immunology (Baltimore, Md. : 1950). PMID 27474074 DOI: 10.4049/Jimmunol.1600717  0.771
2015 Dupont CD, Harms Pritchard G, Hidano S, Christian DA, Wagage S, Muallem G, Tait Wojno ED, Hunter CA. Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis. Journal of Immunology (Baltimore, Md. : 1950). PMID 26385522 DOI: 10.4049/Jimmunol.1500690  0.827
2015 Banigan EJ, Harris TH, Christian DA, Hunter CA, Liu AJ. Heterogeneous CD8+ T cell migration in the lymph node in the absence of inflammation revealed by quantitative migration analysis. Plos Computational Biology. 11: e1004058. PMID 25692801 DOI: 10.1371/Journal.Pcbi.1004058  0.759
2015 Harms Pritchard G, Hall AO, Christian DA, Wagage S, Fang Q, Muallem G, John B, Glatman Zaretsky A, Dunn WG, Perrigoue J, Reiner SL, Hunter CA. Diverse roles for T-bet in the effector responses required for resistance to infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 1131-40. PMID 25556247 DOI: 10.4049/Jimmunol.1401617  0.828
2015 Ruella M, Barrett DM, Kenderian SS, Shestova O, Hofmann TJ, Scholler J, Lacey SF, Melenhorst JJ, Nazimuddin F, Perazzelli J, Christian DA, Hunter CA, Porter DL, June CH, Grupp SA, et al. Treatment of leukemia antigen-loss relapses occurring after CD19-targeted immunotherapies by combination of anti-CD123 and anti-CD19 chimeric antigen receptor T cells Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-O5  0.402
2015 Ruella M, Barrett DM, Kenderian SS, Shestova O, Hofmann TJ, Scholler J, Lacey SF, Melenhorst JJ, Nazimuddin F, Perazzelli J, Christian DA, Hunter CA, Porter DL, June CH, Grupp SA, et al. Combination of Anti-CD123 and Anti-CD19 Chimeric Antigen Receptor T Cells for the Treatment and Prevention of Antigen-Loss Relapses Occurring after CD19-Targeted Immunotherapies Blood. 126: 2523-2523. DOI: 10.1182/Blood.V126.23.2523.2523  0.421
2014 Hunter C, Christian D. Parasite uses host NFAT to co-opt immune response. The Journal of Experimental Medicine. 211: 1923. PMID 25246389 DOI: 10.1084/Jem.21110Insight2  0.502
2014 Christian DA, Koshy AA, Reuter MA, Betts MR, Boothroyd JC, Hunter CA. Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis. Infection and Immunity. 82: 4056-67. PMID 25024368 DOI: 10.1128/Iai.01643-14  0.597
2014 Dupont CD, Christian DA, Selleck EM, Pepper M, Leney-Greene M, Harms Pritchard G, Koshy AA, Wagage S, Reuter MA, Sibley LD, Betts MR, Hunter CA. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. Plos Pathogens. 10: e1004047. PMID 24722202 DOI: 10.1371/Journal.Ppat.1004047  0.846
2014 Beiting DP, Peixoto L, Akopyants NS, Beverley SM, Wherry EJ, Christian DA, Hunter CA, Brodsky IE, Roos DS. Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. Plos One. 9: e88398. PMID 24505488 DOI: 10.1371/Journal.Pone.0088398  0.55
2014 Shin JW, Buxboim A, Spinler KR, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 14: 81-93. PMID 24268694 DOI: 10.1016/J.Stem.2013.10.009  0.776
2013 Rodriguez PL, Harada T, Christian DA, Pantano DA, Tsai RK, Discher DE. Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (New York, N.Y.). 339: 971-5. PMID 23430657 DOI: 10.1126/Science.1229568  0.707
2013 Spinler K, Tian A, Christian DA, Pantano DA, Baumgart T, Discher DE. Dynamic domains in polymersomes: mixtures of polyanionic and neutral diblocks respond more rapidly to changes in calcium than to pH. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 7499-508. PMID 23327600 DOI: 10.1021/La304602E  0.713
2012 Dupont CD, Christian DA, Hunter CA. Immune response and immunopathology during toxoplasmosis. Seminars in Immunopathology. 34: 793-813. PMID 22955326 DOI: 10.1007/S00281-012-0339-3  0.568
2012 Koshy AA, Dietrich HK, Christian DA, Melehani JH, Shastri AJ, Hunter CA, Boothroyd JC. Toxoplasma co-opts host cells it does not invade. Plos Pathogens. 8: e1002825. PMID 22910631 DOI: 10.1371/Journal.Ppat.1002825  0.582
2012 Harris TH, Banigan EJ, Christian DA, Konradt C, Tait Wojno ED, Norose K, Wilson EH, John B, Weninger W, Luster AD, Liu AJ, Hunter CA. Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. Nature. 486: 545-8. PMID 22722867 DOI: 10.1038/Nature11098  0.822
2012 Christian DA, Hunter CA. Particle-mediated delivery of cytokines for immunotherapy. Immunotherapy. 4: 425-41. PMID 22512636 DOI: 10.2217/Imt.12.26  0.539
2011 Ellenbroek WG, Wang YH, Christian DA, Discher DE, Janmey PA, Liu AJ. Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers. Biophysical Journal. 101: 2178-84. PMID 22067156 DOI: 10.1016/J.Bpj.2011.09.039  0.452
2011 John B, Ricart B, Tait Wojno ED, Harris TH, Randall LM, Christian DA, Gregg B, De Almeida DM, Weninger W, Hammer DA, Hunter CA. Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis. Plos Pathogens. 7: e1002246. PMID 21949652 DOI: 10.1371/Journal.Ppat.1002246  0.811
2011 Whitmarsh RJ, Gray CM, Gregg B, Christian DA, May MJ, Murray PJ, Hunter CA. A critical role for SOCS3 in innate resistance to Toxoplasma gondii. Cell Host & Microbe. 10: 224-36. PMID 21925110 DOI: 10.1016/J.Chom.2011.07.009  0.553
2011 Loverde SM, Pantano DA, Christian DA, Mahmud A, Klein ML, Discher DE. Curvature, rigidity, and pattern formation in functional polymer micelles and vesicles-From dynamic visualization to molecular simulation Current Opinion in Solid State and Materials Science. 15: 277-284. DOI: 10.1016/J.Cossms.2011.06.003  0.468
2010 Christian DA, Garbuzenko OB, Minko T, Discher DE. Polymer Vesicles with a Red Cell-like Surface Charge: Microvascular Imaging and in vivo Tracking with Near-Infrared Fluorescence. Macromolecular Rapid Communications. 31: 135-41. PMID 21590885 DOI: 10.1002/Marc.200900589  0.501
2010 Rajagopal K, Mahmud A, Christian DA, Pajerowski JD, Brown AE, Loverde SM, Discher DE. Curvature-coupled hydration of Semicrystalline Polymer Amphiphiles yields flexible Worm Micelles but favors rigid Vesicles: polycaprolactone-based block copolymers. Macromolecules. 43: 9736-9746. PMID 21499509 DOI: 10.1021/Ma101316W  0.776
2010 Rajagopal K, Christian DA, Harada T, Tian A, Discher DE. Polymersomes and wormlike micelles made fluorescent by direct modifications of block copolymer amphiphiles International Journal of Polymer Science. 2010. DOI: 10.1155/2010/379286  0.594
2010 Cai S, Christian DA, Tewari M, Minko T, Discher DE. Anti-cancer polymersomes Rsc Nanoscience and Nanotechnology. 300-312.  0.326
2009 Christian DA, Tian A, Ellenbroek WG, Levental I, Rajagopal K, Janmey PA, Liu AJ, Baumgart T, Discher DE. Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nature Materials. 8: 843-9. PMID 19734886 DOI: 10.1038/Nmat2512  0.459
2009 Levental I, Christian DA, Wang YH, Madara JJ, Discher DE, Janmey PA. Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry. 48: 8241-8. PMID 19630438 DOI: 10.1021/Bi9007879  0.437
2009 Christian DA, Cai S, Garbuzenko OB, Harada T, Zajac AL, Minko T, Discher DE. Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage. Molecular Pharmaceutics. 6: 1343-52. PMID 19249859 DOI: 10.1021/Mp900022M  0.599
2009 Christian DA, Cai S, Bowen DM, Kim Y, Pajerowski JD, Discher DE. Polymersome carriers: from self-assembly to siRNA and protein therapeutics. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 71: 463-74. PMID 18977437 DOI: 10.1016/J.Ejpb.2008.09.025  0.762
2009 Tong R, Christian DA, Tang L, Cabral H, Baker JR, Kataoka K, Discher DE, Cheng J. Nanopolymeric therapeutics Mrs Bulletin. 34: 422-431.  0.347
2008 Christian DA, Rajagopal K, Srinivas G, Klein ML, Discher DE. Nanoparticle incorporation and aggregation in block copolymer worm-like micelles Aiche Annual Meeting, Conference Proceedings 0.356
2008 Christian DA, Bowen DM, Dunn RJ, Discher DE. Anionic nano-polymersomes for enhanced circulation kinetics in vivo Aiche Annual Meeting, Conference Proceedings 0.396
2007 Discher DE, Ortiz V, Srinivas G, Klein ML, Kim Y, Christian D, Cai S, Photos P, Ahmed F. Emerging Applications of Polymersomes in Delivery: from Molecular Dynamics to Shrinkage of Tumors. Progress in Polymer Science. 32: 838-857. PMID 24692840 DOI: 10.1016/J.Progpolymsci.2007.05.011  0.747
2005 Kim Y, Dalhaimer P, Christian DA, Discher DE. Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology. 16: S484-91. PMID 21727469 DOI: 10.1088/0957-4484/16/7/024  0.736
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