John J. Tesmer - Publications

Cell and molecular biology University of Texas at Austin, Austin, Texas, U.S.A. 
Molecular Biology, Biochemistry, General Biophysics

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Cash JN, Davis EM, Tesmer JJ. Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure (London, England : 1993). PMID 27150042 DOI: 10.1016/j.str.2016.02.022  0.6
2016 Yang P, Homan KT, Li Y, Cruz-Rodriguez O, Tesmer JJ, Chen Z. Effect of Lipid Composition on Membrane Orientation of the G protein-coupled Receptor Kinase 2-Gβ1γ2 Complex. Biochemistry. PMID 27088923 DOI: 10.1021/acs.biochem.6b00354  0.6
2015 Inagaki S, Ghirlando R, Vishnivetskiy SA, Homan KT, White JF, Tesmer JJ, Gurevich VV, Grisshammer R. G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro. Biochemistry. 54: 4320-9. PMID 26120872 DOI: 10.1021/acs.biochem.5b00285  0.6
2015 Homan KT, Waldschmidt HV, Glukhova A, Cannavo A, Song J, Cheung JY, Koch WJ, Larsen SD, Tesmer JJ. Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. The Journal of Biological Chemistry. PMID 26032411 DOI: 10.1074/jbc.M115.647370  0.6
2015 Azevedo AW, Doan T, Moaven H, Sokal I, Baameur F, Vishnivetskiy SA, Homan KT, Tesmer JJ, Gurevich VV, Chen J, Rieke F. C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor. Elife. 4. PMID 25910054 DOI: 10.7554/eLife.05981  0.6
2015 Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV. G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). The Journal of Biological Chemistry. 290: 10775-90. PMID 25770216 DOI: 10.1074/jbc.M115.644773  0.6
2015 Glukhova A, Hinkovska-Galcheva V, Kelly R, Abe A, Shayman JA, Tesmer JJ. Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase. Nature Communications. 6: 6250. PMID 25727495 DOI: 10.1038/ncomms7250  0.6
2015 Homan KT, Larimore KM, Elkins JM, Szklarz M, Knapp S, Tesmer JJ. Identification and structure-function analysis of subfamily selective g protein-coupled receptor kinase inhibitors. Acs Chemical Biology. 10: 310-9. PMID 25238254 DOI: 10.1021/cb5006323  0.6
2015 Homan KT, Tesmer JJ. Molecular basis for small molecule inhibition of G protein-coupled receptor kinases. Acs Chemical Biology. 10: 246-56. PMID 24984143 DOI: 10.1021/cb5003976  0.6
2014 Lyon AM, Begley JA, Manett TD, Tesmer JJ. Molecular mechanisms of phospholipase C β3 autoinhibition. Structure (London, England : 1993). 22: 1844-54. PMID 25435326 DOI: 10.1016/j.str.2014.10.008  0.6
2014 Homan KT, Wu E, Cannavo A, Koch WJ, Tesmer JJ. Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor. Molecules (Basel, Switzerland). 19: 16937-49. PMID 25340299 DOI: 10.3390/molecules191016937  0.6
2014 Beautrait A, Michalski KR, Lopez TS, Mannix KM, McDonald DJ, Cutter AR, Medina CB, Hebert AM, Francis CJ, Bouvier M, Tesmer JJ, Sterne-Marr R. Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays. The Journal of Biological Chemistry. 289: 25262-75. PMID 25049229 DOI: 10.1074/jbc.M114.593178  0.6
2014 Swanson CJ, Ritt M, Wang W, Lang MJ, Narayan A, Tesmer JJ, Westfall M, Sivaramakrishnan S. Conserved modular domains team up to latch-open active protein kinase Cα. The Journal of Biological Chemistry. 289: 17812-29. PMID 24790081 DOI: 10.1074/jbc.M113.534750  0.6
2014 Homan KT, Tesmer JJ. Structural insights into G protein-coupled receptor kinase function. Current Opinion in Cell Biology. 27: 25-31. PMID 24680427 DOI: 10.1016/  0.6
2014 Ding B, Glukhova A, Sobczyk-Kojiro K, Mosberg HI, Tesmer JJ, Chen Z. Unveiling the membrane-binding properties of N-terminal and C-terminal regions of G protein-coupled receptor kinase 5 by combined optical spectroscopies. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 823-31. PMID 24401145 DOI: 10.1021/la404055a  0.6
2014 Lyon AM, Taylor VG, Tesmer JJ. Strike a pose: Gαq complexes at the membrane. Trends in Pharmacological Sciences. 35: 23-30. PMID 24287282 DOI: 10.1016/  0.6
2014 Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Molecular Pharmacology. 85: 237-48. PMID 24220010 DOI: 10.1124/mol.113.089631  0.6
2013 Vishnivetskiy SA, Ostermaier MK, Singhal A, Panneels V, Homan KT, Glukhova A, Sligar SG, Tesmer JJ, Schertler GF, Standfuss J, Gurevich VV. Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding. Cellular Signalling. 25: 2155-62. PMID 23872075 DOI: 10.1016/j.cellsig.2013.07.009  0.6
2013 Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J. Insights into congenital stationary night blindness based on the structure of G90D rhodopsin. Embo Reports. 14: 520-6. PMID 23579341 DOI: 10.1038/embor.2013.44  0.6
2013 Yang P, Boughton A, Homan KT, Tesmer JJ, Chen Z. Membrane orientation of Gα(i)β(1)γ(2) and Gβ(1)γ(2) determined via combined vibrational spectroscopic studies. Journal of the American Chemical Society. 135: 5044-51. PMID 23461393 DOI: 10.1021/ja3116026  0.6
2013 Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ. Structural and functional analysis of the regulator of G protein signaling 2-gαq complex. Structure (London, England : 1993). 21: 438-48. PMID 23434405 DOI: 10.1016/j.str.2012.12.016  0.56
2013 Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ. Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain. Nature Structural & Molecular Biology. 20: 355-62. PMID 23377541 DOI: 10.1038/nsmb.2497  0.6
2013 Sterne-Marr R, Baillargeon AI, Michalski KR, Tesmer JJG. Expression, purification, and analysis of G-protein-coupled receptor kinases Methods in Enzymology. 521: 347-366. PMID 23351749 DOI: 10.1016/B978-0-12-391862-8.00019-3  0.6
2012 Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, Tesmer JJ. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Acs Chemical Biology. 7: 1830-9. PMID 22882301 DOI: 10.1021/cb3003013  0.6
2012 Tesmer VM, Lennarz S, Mayer G, Tesmer JJ. Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer. Structure (London, England : 1993). 20: 1300-9. PMID 22727813 DOI: 10.1016/j.str.2012.05.002  0.36
2012 Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K. Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1). Biochemistry. 51: 3404-11. PMID 22480180 DOI: 10.1021/bi300295y  0.6
2012 Edwards BS, Zhu J, Chen J, Carter MB, Thal DM, Tesmer JJ, Graves SW, Sklar LA. Cluster cytometry for high-capacity bioanalysis. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 81: 419-29. PMID 22438314 DOI: 10.1002/cyto.a.22039  0.6
2012 Gurevich EV, Tesmer JJ, Mushegian A, Gurevich VV. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacology & Therapeutics. 133: 40-69. PMID 21903131 DOI: 10.1016/j.pharmthera.2011.08.001  0.6
2011 Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko MC, Woods JH, Tesmer JJ, Sunahara RK. Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Molecular Pharmacology. 80: 1056-65. PMID 21890748 DOI: 10.1124/mol.111.074997  0.6
2011 Boughton AP, Yang P, Tesmer VM, Ding B, Tesmer JJ, Chen Z. Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane. Proceedings of the National Academy of Sciences of the United States of America. 108: E667-73. PMID 21876134 DOI: 10.1073/pnas.1108236108  0.6
2011 Lyon AM, Tesmer VM, Dhamsania VD, Thal DM, Gutierrez J, Chowdhury S, Suddala KC, Northup JK, Tesmer JJ. An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation. Nature Structural & Molecular Biology. 18: 999-1005. PMID 21822282 DOI: 10.1038/nsmb.2095  0.36
2011 Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry. 50: 1940-9. PMID 21265573 DOI: 10.1021/bi101606e  0.6
2011 Bayburt TH, Vishnivetskiy SA, McLean MA, Morizumi T, Huang CC, Tesmer JJ, Ernst OP, Sligar SG, Gurevich VV. Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding. The Journal of Biological Chemistry. 286: 1420-8. PMID 20966068 DOI: 10.1074/jbc.M110.151043  0.6
2010 Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara RK. Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Engineering, Design & Selection : Peds. 23: 537-47. PMID 20436035 DOI: 10.1093/protein/gzq025  0.6
2010 Shankaranarayanan A, Boguth CA, Lutz S, Vettel C, Uhlemann F, Aittaleb M, Wieland T, Tesmer JJ. Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF. Cellular Signalling. 22: 1114-23. PMID 20214977 DOI: 10.1016/j.cellsig.2010.03.006  0.6
2010 Tesmer JJ, Tesmer VM, Lodowski DT, Steinhagen H, Huber J. Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. Journal of Medicinal Chemistry. 53: 1867-70. PMID 20128603 DOI: 10.1021/jm9017515  0.6
2010 Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara RK, Woods JH. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Molecular Pharmacology. 77: 593-600. PMID 20086035 DOI: 10.1124/mol.109.060806  0.6
2010 Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/j.1471-4159.2009.06519.x  0.6
2009 Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ. A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells. Cellular Signalling. 21: 1569-78. PMID 19560536 DOI: 10.1016/j.cellsig.2009.06.003  0.6
2009 Sterne-Marr R, Leahey PA, Bresee JE, Dickson HM, Ho W, Ragusa MJ, Donnelly RM, Amie SM, Krywy JA, Brookins-Danz ED, Orakwue SC, Carr MJ, Yoshino-Koh K, Li Q, Tesmer JJ. GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail. Biochemistry. 48: 4285-93. PMID 19338266 DOI: 10.1021/bi900151g  0.6
2008 Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ. Assembly of high order G alpha q-effector complexes with RGS proteins. The Journal of Biological Chemistry. 283: 34923-34. PMID 18936096 DOI: 10.1074/jbc.M805860200  0.6
2007 Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science (New York, N.Y.). 318: 1923-7. PMID 18096806 DOI: 10.1126/science.1147554  0.6
2007 Williams SL, Lutz S, Charlie NK, Vettel C, Ailion M, Coco C, Tesmer JJ, Jorgensen EM, Wieland T, Miller KG. Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans. Genes & Development. 21: 2731-46. PMID 17942708 DOI: 10.1101/gad.1592007  0.6
2007 Chen X, Boughton AP, Tesmer JJ, Chen Z. In situ investigation of heterotrimeric G protein betagamma subunit binding and orientation on membrane bilayers. Journal of the American Chemical Society. 129: 12658-9. PMID 17902674 DOI: 10.1021/ja075542w  0.6
2007 Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP. Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. The Journal of Biological Chemistry. 282: 33064-75. PMID 17848575 DOI: 10.1074/jbc.M702685200  0.6
2007 Li Q, Nance MR, Kulikauskas R, Nyberg K, Fehon R, Karplus PA, Bretscher A, Tesmer JJ. Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. Journal of Molecular Biology. 365: 1446-59. PMID 17134719 DOI: 10.1016/j.jmb.2006.10.075  0.6
2006 Lodowski DT, Tesmer VM, Benovic JL, Tesmer JJ. The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. The Journal of Biological Chemistry. 281: 16785-93. PMID 16613860 DOI: 10.1074/jbc.M601327200  0.6
2005 Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ. Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex. Science (New York, N.Y.). 310: 1686-90. PMID 16339447 DOI: 10.1126/science.1118890  0.6
2005 Lodowski DT, Barnhill JF, Pyskadlo RM, Ghirlando R, Sterne-Marr R, Tesmer JJ. The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2. Biochemistry. 44: 6958-70. PMID 15865441 DOI: 10.1021/bi050119q  0.6
2004 Sterne-Marr R, Dhami GK, Tesmer JJ, Ferguson SS. Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins. Methods in Enzymology. 390: 310-36. PMID 15488186 DOI: 10.1016/S0076-6879(04)90020-1  0.56
2004 Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB. Characterization of the GRK2 binding site of Galphaq. The Journal of Biological Chemistry. 279: 53643-52. PMID 15471870 DOI: 10.1074/jbc.M401438200  0.6
2004 Kristelly R, Gao G, Tesmer JJ. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. The Journal of Biological Chemistry. 279: 47352-62. PMID 15331592 DOI: 10.1074/jbc.M406056200  0.6
2003 Kristelly R, Earnest BT, Krishnamoorthy L, Tesmer JJ. Preliminary structure analysis of the DH/PH domains of leukemia-associated RhoGEF. Acta Crystallographica. Section D, Biological Crystallography. 59: 1859-62. PMID 14501138 DOI: 10.1107/S0907444903018067  0.6
2003 Lodowski DT, Barnhill JF, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ. Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. Acta Crystallographica. Section D, Biological Crystallography. 59: 936-9. PMID 12777817 DOI: 10.1107/S0907444903002622  0.6
2003 Lodowski DT, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ. Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science (New York, N.Y.). 300: 1256-62. PMID 12764189 DOI: 10.1126/science.1082348  0.6
2003 Sterne-Marr R, Tesmer JJ, Day PW, Stracquatanio RP, Cilente JA, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. The Journal of Biological Chemistry. 278: 6050-8. PMID 12427730 DOI: 10.1074/jbc.M208787200  0.6
2002 Tesmer JJ, Sunahara RK, Fancy DA, Gilman AG, Sprang SR. Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. Methods in Enzymology. 345: 198-206. PMID 11665605 DOI: 10.1016/S0076-6879(02)45017-3  0.6
1999 Posner BA, Mukhopadhyay S, Tesmer JJ, Gilman AG, Ross EM. Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue. Biochemistry. 38: 7773-9. PMID 10387017 DOI: 10.1021/bi9906367  0.6
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