Owen N. Witte - Publications

Affiliations: 
Molecular Biology 0573 University of California, Los Angeles, Los Angeles, CA 
Area:
Molecular Biology, Oncology

303 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, ... ... Witte ON, et al. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. PMID 31495780 DOI: 10.1016/j.stem.2019.08.004  0.76
2019 Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, ... ... Witte ON, et al. Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Reports. 28: 2728-2738.e7. PMID 31484081 DOI: 10.1016/j.celrep.2019.07.106  1
2019 Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. Cancer Cell. 36: 17-34.e7. PMID 31287989 DOI: 10.1016/j.ccell.2019.06.005  0.44
2019 Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, De Hoedt AM, Stuart J, Goldstein T, Chi K, ... ... Witte ON, et al. MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer. Prostate Cancer and Prostatic Diseases. PMID 30804427 DOI: 10.1038/s41391-019-0134-5  0.44
2019 Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, et al. T cell antigen discovery via trogocytosis. Nature Methods. 16: 183-190. PMID 30700903 DOI: 10.1038/s41592-018-0305-7  1
2018 Puig-Saus C, Parisi G, Garcia-Diaz A, Krystofinski PE, Sandoval S, Zhang R, Champhekar AS, McCabe J, Cheung-Lau GC, Truong NA, Vega-Crespo A, Komenan MDS, Pang J, Macabali MH, Saco JD, ... ... Witte ON, et al. IND-enabling studies for a clinical trial to genetically program a persistent cancer-targeted immune system. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30409823 DOI: 10.1158/1078-0432.CCR-18-0963  1
2018 Bethune MT, Li XH, Yu J, McLaughlin J, Cheng D, Mathis C, Moreno BH, Woods K, Knights AJ, Garcia-Diaz A, Wong S, Hu-Lieskovan S, Puig-Saus C, Cebon J, Ribas A, ... ... Witte ON, et al. Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348802 DOI: 10.1073/pnas.1810653115  1
2018 Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science (New York, N.Y.). 362: 91-95. PMID 30287662 DOI: 10.1126/science.aat5749  0.76
2018 Smith BA, Balanis NG, Nanjundiah A, Sheu KM, Tsai BL, Zhang Q, Park JW, Thompson M, Huang J, Witte ON, Graeber TG. A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers. Cell Reports. 24: 3353-3366.e5. PMID 30232014 DOI: 10.1016/j.celrep.2018.08.062  0.44
2018 Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, et al. Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2017776880. PMID 29985747 DOI: 10.1200/JCO.2017.77.6880  0.44
2018 Salas JR, Chen BY, Wong A, Cheng D, Van Arnam JS, Witte ON, Clark PM. F-FAC PET selectively images hepatic infiltrating CD4 and CD8 T cells in a mouse model of autoimmune hepatitis. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 29700125 DOI: 10.2967/jnumed.118.210328  0.76
2018 Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 29686080 DOI: 10.1073/pnas.1802354115  0.44
2017 Park JW, Lee JK, Witte ON, Huang J. FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 28621319 DOI: 10.1038/modpathol.2017.44  0.44
2017 Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1 pre-B ALL. The Journal of Experimental Medicine. 214: 793-814. PMID 28190001 DOI: 10.1084/jem.20160049  0.76
2016 Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, ... ... Witte ON, et al. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Reports. 17: 2596-2606. PMID 27926864 DOI: 10.1016/j.celrep.2016.11.010  0.92
2016 Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, ... ... Witte ON, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27694579 DOI: 10.1073/pnas.1614529113  1
2016 Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, ... ... Witte ON, et al. Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. PMID 27499020 DOI: 10.1016/j.cell.2016.07.007  1
2016 McCracken MN, Tavaré R, Witte ON, Wu AM. Advances in PET Detection of the Antitumor T Cell Response. Advances in Immunology. 131: 187-231. PMID 27235684 DOI: 10.1016/bs.ai.2016.02.004  0.36
2016 Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, ... Witte ON, et al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 29: 536-47. PMID 27050099 DOI: 10.1016/j.ccell.2016.03.001  0.76
2016 Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044116 DOI: 10.1073/pnas.1603645113  1
2016 Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, ... ... Witte ON, et al. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035974 DOI: 10.1073/pnas.1524212113  0.6
2016 Witte ON. Role of the BCR-ABL Oncogene in Human Leukemia: Fifteenth Richard and Hinda Rosenthal Foundation Award Lecture Cancer Research. 53: 485-489. PMID 8425181  1
2015 Zong Y, Goldstein AS, Witte ON. Tissue Recombination Models for the Study of Epithelial Cancer. Cold Spring Harbor Protocols. 2015: pdb.top069880. PMID 26631129 DOI: 10.1101/pdb.top069880  0.6
2015 Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26621741 DOI: 10.1073/pnas.1521674112  1
2015 Tavare R, Escuin-Ordinas H, Mok S, McCracken MN, Zettlitz KA, Salazar FB, Witte ON, Ribas A, Wu AM. An effective immuno-PET imaging method to monitor CD8-dependent responses to immunotherapy. Cancer Research. PMID 26573799 DOI: 10.1158/0008-5472.CAN-15-1707  0.36
2015 Sharma A, Sebastiano V, Scott CT, Magnus D, Koyano-Nakagawa N, Garry DJ, Witte ON, Nakauchi H, Wu JC, Weissman IL, Wu SM. Lift NIH restrictions on chimera research. Science (New York, N.Y.). 350: 640. PMID 26542560 DOI: 10.1126/science.350.6261.640-a  0.6
2015 Zong Y, Goldstein AS, Witte ON. Dissociated Prostate Regeneration under the Renal Capsule. Cold Spring Harbor Protocols. 2015: pdb.prot078063. PMID 26527760 DOI: 10.1101/pdb.prot078063  0.6
2015 Zong Y, Goldstein AS, Witte ON. Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models. Cold Spring Harbor Protocols. 2015: pdb.prot078055. PMID 26527759 DOI: 10.1101/pdb.prot078055  0.6
2015 Smith BA, Sokolov A, Uzunangelov V, Baertsch R, Newton Y, Graim K, Mathis C, Cheng D, Stuart JM, Witte ON. A basal stem cell signature identifies aggressive prostate cancer phenotypes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26460041 DOI: 10.1073/pnas.1518007112  1
2015 Evdokimov NM, Clark PM, Flores G, Chai T, Faull KF, Phelps ME, Witte ON, Jung ME. Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. Journal of Medicinal Chemistry. 58: 5538-47. PMID 26102222 DOI: 10.1021/acs.jmedchem.5b00569  1
2015 Tavare R, McCracken MN, Zettlitz KA, Salazar FB, Olafsen T, Witte ON, Wu AM. ImmunoPET of murine T cell reconstitution post-adoptive stem cell transplant using anti-CD4 and anti-CD8 cys-diabodies. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 25952734 DOI: 10.2967/jnumed.114.153338  0.44
2015 McCracken MN, Vatakis DN, Dixit D, McLaughlin J, Zack JA, Witte ON. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. The Journal of Clinical Investigation. 125: 1815-26. PMID 25822024 DOI: 10.1172/JCI77326  1
2015 Smith DJ, Liu S, Ji S, Li B, McLaughlin J, Cheng D, Witte ON, Yang L. Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 1523-8. PMID 25605948 DOI: 10.1073/pnas.1424877112  1
2014 Bunimovich YL, Nair-Gill E, Riedinger M, McCracken MN, Cheng D, McLaughlin J, Radu CG, Witte ON. Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. Plos One. 9: e104125. PMID 25101980 DOI: 10.1371/journal.pone.0104125  1
2014 Gschweng EH, McCracken MN, Kaufman ML, Ho M, Hollis RP, Wang X, Saini N, Koya RC, Chodon T, Ribas A, Witte ON, Kohn DB. HSV-sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice. Cancer Research. 74: 5173-83. PMID 25038231 DOI: 10.1158/0008-5472.CAN-14-0376  1
2014 Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proceedings of the National Academy of Sciences of the United States of America. 111: E2866-74. PMID 24982199 DOI: 10.1073/pnas.1410326111  1
2014 Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, ... ... Witte ON, et al. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2457-65. PMID 24634374 DOI: 10.1158/1078-0432.CCR-13-3017  1
2014 Drake JM, Lee JK, Witte ON. Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. Molecular and Cellular Biology. 34: 1722-32. PMID 24567371 DOI: 10.1128/MCB.01592-13  1
2014 Tavaré R, McCracken MN, Zettlitz KA, Knowles SM, Salazar FB, Olafsen T, Witte ON, Wu AM. Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 1108-13. PMID 24390540 DOI: 10.1073/pnas.1316922111  1
2013 Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 20111-6. PMID 24282295 DOI: 10.1073/pnas.1320565110  1
2013 Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CM, Sud S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proceedings of the National Academy of Sciences of the United States of America. 110: E4762-9. PMID 24248375 DOI: 10.1073/pnas.1319948110  1
2013 Janzen DM, Paik DY, Rosales MA, Yep B, Cheng D, Witte ON, Kayadibi H, Ryan CM, Jung ME, Faull K, Memarzadeh S. Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Molecular Cancer Therapeutics. 12: 2917-28. PMID 24222661 DOI: 10.1158/1535-7163.MCT-13-0572  1
2013 Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nature Immunology. 14: 1073-83. PMID 24013668 DOI: 10.1038/ni.2707  0.76
2013 Zangle TA, Burnes D, Mathis C, Witte ON, Teitell MA. Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. Plos One. 8: e68916. PMID 23935904 DOI: 10.1371/journal.pone.0068916  1
2013 Goldstein AS, Witte ON. Does the microenvironment influence the cell types of origin for prostate cancer? Genes & Development. 27: 1539-44. PMID 23873937 DOI: 10.1101/gad.222380.113  1
2013 Smith DA, Kiba A, Zong Y, Witte ON. Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues. Molecular Cancer Research : McR. 11: 1159-65. PMID 23867565 DOI: 10.1158/1541-7786.MCR-13-0238  1
2013 Janzen DM, Rosales MA, Paik DY, Lee DS, Smith DA, Witte ON, Iruela-Arispe ML, Memarzadeh S. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer Research. 73: 4697-710. PMID 23744837 DOI: 10.1158/0008-5472.CAN-13-0930  1
2013 Ma C, Cheung AF, Chodon T, Koya RC, Wu Z, Ng C, Avramis E, Cochran AJ, Witte ON, Baltimore D, Chmielowski B, Economou JS, Comin-Anduix B, Ribas A, Heath JR. Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy. Cancer Discovery. 3: 418-29. PMID 23519018 DOI: 10.1158/2159-8290.CD-12-0383  1
2013 Giannoni F, Hardee CL, Wherley J, Gschweng E, Senadheera S, Kaufman ML, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte ON, Economou JS, Ribas A, et al. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1044-54. PMID 23380815 DOI: 10.1038/mt.2013.8  1
2013 Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem Cells (Dayton, Ohio). 31: 808-22. PMID 23341289 DOI: 10.1002/stem.1337  1
2013 McCracken MN, Gschweng EH, Nair-Gill E, McLaughlin J, Cooper AR, Riedinger M, Cheng D, Nosala C, Kohn DB, Witte ON. Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene. Proceedings of the National Academy of Sciences of the United States of America. 110: 1857-62. PMID 23319634 DOI: 10.1073/pnas.1221840110  1
2013 Gil JS, Machado HB, Campbell DO, McCracken M, Radu C, Witte ON, Herschman HR. Application of a rapid, simple, and accurate adenovirus-based method to compare PET reporter gene/PET reporter probe systems. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 15: 273-81. PMID 23054556 DOI: 10.1007/s11307-012-0596-5  1
2012 Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discovery. 2: 1109-17. PMID 23230188 DOI: 10.1158/2159-8290.CD-12-0197  1
2012 Zong Y, Huang J, Sankarasharma D, Morikawa T, Fukayama M, Epstein JI, Chada KK, Witte ON. Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: E3395-404. PMID 23184966 DOI: 10.1073/pnas.1217982109  1
2012 Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. The Journal of Experimental Medicine. 209: 2215-28. PMID 23148236 DOI: 10.1084/jem.20121061  1
2012 Goldstein AS, Witte ON. A plethora of progenitors in the post-natal prostate. Embo Reports. 13: 1036-7. PMID 23138032 DOI: 10.1038/embor.2012.169  1
2012 Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes & Development. 26: 2271-85. PMID 23070813 DOI: 10.1101/gad.196451.112  1
2012 Paik DY, Janzen DM, Schafenacker AM, Velasco VS, Shung MS, Cheng D, Huang J, Witte ON, Memarzadeh S. Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation. Stem Cells (Dayton, Ohio). 30: 2487-97. PMID 22911892 DOI: 10.1002/stem.1207  1
2012 Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. Plos One. 7: e42564. PMID 22880034 DOI: 10.1371/journal.pone.0042564  1
2012 Cai H, Memarzadeh S, Stoyanova T, Beharry Z, Kraft AS, Witte ON. Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer Research. 72: 4672-81. PMID 22805308 DOI: 10.1158/0008-5472.CAN-12-0228  1
2012 Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993. Journal of Immunology (Baltimore, Md. : 1950). 188: 2936-47. PMID 22442491  1
2012 Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 109: 1643-8. PMID 22307624 DOI: 10.1073/pnas.1120985109  1
2012 Goldstein AS, Witte ON. Isolation and characterization of prostate stem cells Stem Cells and Prostate Cancer. 21-36. DOI: 10.1007/978-1-4614-6498-3_2  1
2011 Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang LV. Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. Plos One. 6: e27586. PMID 22110680 DOI: 10.1371/journal.pone.0027586  0.32
2011 Goldstein AS, Drake JM, Burnes DL, Finley DS, Zhang H, Reiter RE, Huang J, Witte ON. Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nature Protocols. 6: 656-67. PMID 21527922 DOI: 10.1038/nprot.2011.317  1
2011 Memarzadeh S, Cai H, Janzen DM, Xin L, Lukacs R, Riedinger M, Zong Y, DeGendt K, Verhoeven G, Huang J, Witte ON. Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proceedings of the National Academy of Sciences of the United States of America. 108: 7962-7. PMID 21518863 DOI: 10.1073/pnas.1105243108  1
2011 Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 108: 6579-84. PMID 21464326 DOI: 10.1073/pnas.1103904108  1
2011 Goldstein AS, Zong Y, Witte ON. A two-step toward personalized therapies for prostate cancer. Science Translational Medicine. 3: 72ps7. PMID 21368221 DOI: 10.1126/scitranslmed.3002169  1
2011 Tsutsui H, Valamehr B, Hindoyan A, Qiao R, Ding X, Guo S, Witte ON, Liu X, Ho CM, Wu H. An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nature Communications. 2: 167. PMID 21266967 DOI: 10.1038/ncomms1165  1
2011 Wu TH, Teslaa T, Kalim S, French CT, Moghadam S, Wall R, Miller JF, Witte ON, Teitell MA, Chiou PY. Photothermal nanoblade for large cargo delivery into mammalian cells. Analytical Chemistry. 83: 1321-7. PMID 21247066 DOI: 10.1021/ac102532w  1
2011 Huang X, Gschweng E, Van Handel B, Cheng D, Mikkola HK, Witte ON. Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. Blood. 117: 2157-65. PMID 21163928 DOI: 10.1182/blood-2010-08-302711  1
2011 Cai H, Babic I, Wei X, Huang J, Witte ON. Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer Research. 71: 862-72. PMID 21135112 DOI: 10.1158/0008-5472.CAN-10-1605  1
2011 Schwarzenberg J, Radu CG, Benz M, Fueger B, Tran AQ, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Schiepers C. Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway. European Journal of Nuclear Medicine and Molecular Imaging. 38: 711-21. PMID 21127859 DOI: 10.1007/s00259-010-1666-z  1
2010 Lukacs RU, Memarzadeh S, Wu H, Witte ON. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell. 7: 682-93. PMID 21112563 DOI: 10.1016/j.stem.2010.11.013  1
2010 Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proceedings of the National Academy of Sciences of the United States of America. 107: 17298-303. PMID 20855612 DOI: 10.1073/pnas.1012548107  1
2010 Goldstein AS, Stoyanova T, Witte ON. Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Molecular Oncology. 4: 385-96. PMID 20688584 DOI: 10.1016/j.molonc.2010.06.009  1
2010 Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. Identification of a cell of origin for human prostate cancer. Science (New York, N.Y.). 329: 568-71. PMID 20671189 DOI: 10.1126/science.1189992  1
2010 Koya RC, Mok S, Comin-Anduix B, Chodon T, Radu CG, Nishimura MI, Witte ON, Ribas A. Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses. Proceedings of the National Academy of Sciences of the United States of America. 107: 14286-91. PMID 20624956 DOI: 10.1073/pnas.1008300107  1
2010 Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 116: 2522-30. PMID 20562326 DOI: 10.1182/blood-2010-01-264093  1
2010 Shu CJ, Campbell DO, Lee JT, Tran AQ, Wengrod JC, Witte ON, Phelps ME, Satyamurthy N, Czernin J, Radu CG. Novel PET probes specific for deoxycytidine kinase. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 51: 1092-8. PMID 20554721 DOI: 10.2967/jnumed.109.073361  1
2010 Nair-Gill E, Wiltzius SM, Wei XX, Cheng D, Riedinger M, Radu CG, Witte ON. PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice. The Journal of Clinical Investigation. 120: 2005-15. PMID 20484820 DOI: 10.1172/JCI41250  1
2010 Kamei K, Ohashi M, Gschweng E, Ho Q, Suh J, Tang J, For Yu ZT, Clark AT, Pyle AD, Teitell MA, Lee KB, Witte ON, Tseng HR. Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab On a Chip. 10: 1113-9. PMID 20390128 DOI: 10.1039/b922884e  1
2010 Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. Isolation, cultivation and characterization of adult murine prostate stem cells. Nature Protocols. 5: 702-13. PMID 20360765 DOI: 10.1038/nprot.2010.11  1
2010 Mikkola HK, Radu CG, Witte ON. Targeting leukemia stem cells. Nature Biotechnology. 28: 237-8. PMID 20212485 DOI: 10.1038/nbt0310-237  1
2010 Lawson DA, Zong Y, Memarzadeh S, Xin L, Huang J, Witte ON. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proceedings of the National Academy of Sciences of the United States of America. 107: 2610-5. PMID 20133806 DOI: 10.1073/pnas.0913873107  1
2010 Toy G, Austin WR, Liao HI, Cheng D, Singh A, Campbell DO, Ishikawa TO, Lehmann LW, Satyamurthy N, Phelps ME, Herschman HR, Czernin J, Witte ON, Radu CG. Requirement for deoxycytidine kinase in T and B lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. 107: 5551-6. PMID 20080663 DOI: 10.1073/pnas.0913900107  1
2010 Brewer S, Nair-Gill E, Wei B, Chen L, Li X, Riedinger M, Campbell DO, Wiltzius S, Satyamurthy N, Phelps ME, Radu C, Witte ON, Braun J. Epithelial uptake of [18F]1-(2'-deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice. Gastroenterology. 138: 1266-75. PMID 20080095 DOI: 10.1053/j.gastro.2010.01.003  1
2010 Huang J, Witte ON. A seminal finding for prostate cancer? The New England Journal of Medicine. 362: 175-6. PMID 20071710 DOI: 10.1056/NEJMcibr0909965  1
2010 Baltimore D, Witte ON, Yang L, Economou J, Ribas A. Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma. Pigment Cell & Melanoma Research. 23: 288-9. PMID 20067554 DOI: 10.1111/j.1755-148X.2010.00666.x  1
2010 Garraway IP, Sun W, Tran CP, Perner S, Zhang B, Goldstein AS, Hahm SA, Haider M, Head CS, Reiter RE, Rubin MA, Witte ON. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. The Prostate. 70: 491-501. PMID 19938015 DOI: 10.1002/pros.21083  1
2010 Laing RE, Nair-Gill E, Witte ON, Radu CG. Visualizing cancer and immune cell function with metabolic positron emission tomography. Current Opinion in Genetics & Development. 20: 100-5. PMID 19931447 DOI: 10.1016/j.gde.2009.10.008  1
2009 Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood. 114: 2774-82. PMID 19641187 DOI: 10.1182/blood-2009-05-220681  1
2009 Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 12465-70. PMID 19592505 DOI: 10.1073/pnas.0905931106  1
2009 Kwong GA, Radu CG, Hwang K, Shu CJ, Ma C, Koya RC, Comin-Anduix B, Hadrup SR, Bailey RC, Witte ON, Schumacher TN, Ribas A, Heath JR. Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. Journal of the American Chemical Society. 131: 9695-703. PMID 19552409 DOI: 10.1021/ja9006707  1
2009 Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Phelps ME, Czernin J, Witte ON, Radu CG. Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 106: 2847-52. PMID 19196993 DOI: 10.1073/pnas.0812890106  1
2009 Kamei K, Guo S, Yu ZT, Takahashi H, Gschweng E, Suh C, Wang X, Tang J, McLaughlin J, Witte ON, Lee KB, Tseng HR. An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells. Lab On a Chip. 9: 555-63. PMID 19190791 DOI: 10.1039/b809105f  1
2009 Yu ZT, Kamei K, Takahashi H, Shu CJ, Wang X, He GW, Silverman R, Radu CG, Witte ON, Lee KB, Tseng HR. Integrated microfluidic devices for combinatorial cell-based assays. Biomedical Microdevices. 11: 547-55. PMID 19130244 DOI: 10.1007/s10544-008-9260-x  1
2009 Shu CJ, Radu CG, Shelly SM, Vo DD, Prins R, Ribas A, Phelps ME, Witte ON. Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen. International Immunology. 21: 155-65. PMID 19106231 DOI: 10.1093/intimm/dxn133  1
2008 Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proceedings of the National Academy of Sciences of the United States of America. 105: 20882-7. PMID 19088204 DOI: 10.1073/pnas.0811411106  1
2008 Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes & Development. 22: 3115-20. PMID 19056891 DOI: 10.1101/gad.1715808  1
2008 Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. Epithelial stem cells of the prostate and their role in cancer progression. Cold Spring Harbor Symposia On Quantitative Biology. 73: 491-502. PMID 19022743 DOI: 10.1101/sqb.2008.73.012  1
2008 Valamehr B, Jonas SJ, Polleux J, Qiao R, Guo S, Gschweng EH, Stiles B, Kam K, Luo TJ, Witte ON, Liu X, Dunn B, Wu H. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proceedings of the National Academy of Sciences of the United States of America. 105: 14459-64. PMID 18791068 DOI: 10.1073/pnas.0807235105  0.52
2008 Radu CG, Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON. Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog. Nature Medicine. 14: 783-8. PMID 18542051 DOI: 10.1038/nm1724  1
2008 Lo RS, Witte ON. Transforming growth factor-beta activation promotes genetic context-dependent invasion of immortalized melanocytes. Cancer Research. 68: 4248-57. PMID 18519684 DOI: 10.1158/0008-5472.CAN-07-5671  1
2008 Nair-Gill ED, Shu CJ, Radu CG, Witte ON. Non-invasive imaging of adaptive immunity using positron emission tomography. Immunological Reviews. 221: 214-28. PMID 18275485 DOI: 10.1111/j.1600-065X.2008.00585.x  1
2008 Prins RM, Shu CJ, Radu CG, Vo DD, Khan-Farooqi H, Soto H, Yang MY, Lin MS, Shelly S, Witte ON, Ribas A, Liau LM. Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain. Cancer Immunology, Immunotherapy : Cii. 57: 1279-89. PMID 18253732 DOI: 10.1007/s00262-008-0461-1  1
2008 Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. The Journal of Biological Chemistry. 283: 5296-305. PMID 18089568 DOI: 10.1074/jbc.M706586200  1
2008 Moore ML, Teitell MA, Kim Y, Watabe T, Reiter RE, Witte ON, Dubey P. Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. The Prostate. 68: 139-51. PMID 18044730 DOI: 10.1002/pros.20686  1
2007 McLaughlin J, Cheng D, Singer O, Lukacs RU, Radu CG, Verma IM, Witte ON. Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proceedings of the National Academy of Sciences of the United States of America. 104: 20501-6. PMID 18079287 DOI: 10.1073/pnas.0710532105  1
2007 Memarzadeh S, Xin L, Mulholland DJ, Mansukhani A, Wu H, Teitell MA, Witte ON. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 12: 572-85. PMID 18068633 DOI: 10.1016/j.ccr.2007.11.002  1
2007 Dorshkind K, Witte ON. Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL. Genes & Development. 21: 2249-52. PMID 17875661 DOI: 10.1101/gad.1600307  1
2007 Lawson DA, Witte ON. Stem cells in prostate cancer initiation and progression. The Journal of Clinical Investigation. 117: 2044-50. PMID 17671638 DOI: 10.1172/JCI32810  1
2007 Xin L, Lukacs RU, Lawson DA, Cheng D, Witte ON. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells (Dayton, Ohio). 25: 2760-9. PMID 17641240 DOI: 10.1634/stemcells.2007-0355  1
2007 Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 110: 1831-9. PMID 17554060 DOI: 10.1182/blood-2007-01-069401  1
2007 Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 104: 1937-42. PMID 17261805 DOI: 10.1073/pnas.0610544104  1
2007 Bailey RC, Kwong GA, Radu CG, Witte ON, Heath JR. DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins. Journal of the American Chemical Society. 129: 1959-67. PMID 17260987 DOI: 10.1021/ja065930i  1
2007 Lawson DA, Xin L, Lukacs RU, Cheng D, Witte ON. Isolation and functional characterization of murine prostate stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 181-6. PMID 17185413 DOI: 10.1073/pnas.0609684104  1
2007 Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Molecular and Cellular Biology. 27: 1334-47. PMID 17145776 DOI: 10.1128/MCB.01909-06  1
2006 Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 9: 367-78. PMID 16697957 DOI: 10.1016/j.ccr.2006.03.031  0.64
2006 Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proceedings of the National Academy of Sciences of the United States of America. 103: 7789-94. PMID 16682621 DOI: 10.1073/pnas.0602567103  1
2006 Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proceedings of the National Academy of Sciences of the United States of America. 103: 1480-5. PMID 16432235 DOI: 10.1073/pnas.0510652103  1
2006 Khan AQ, Sen G, Guo S, Witte ON, Snapper CM. Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses. Infection and Immunity. 74: 1419-24. PMID 16428797 DOI: 10.1128/IAI.74.2.1419-1424.2006  1
2006 Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON. Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Molecular and Cellular Biology. 26: 668-77. PMID 16382156 DOI: 10.1128/MCB.26.2.668-677.2006  1
2006 Guo S, Wahl MI, Witte ON. Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families. International Immunology. 18: 79-87. PMID 16291652 DOI: 10.1093/intimm/dxh351  1
2005 Lawson DA, Xin L, Lukacs R, Xu Q, Cheng D, Witte ON. Prostate stem cells and prostate cancer. Cold Spring Harbor Symposia On Quantitative Biology. 70: 187-96. PMID 16869753 DOI: 10.1101/sqb.2005.70.003  1
2005 Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, et al. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science (New York, N.Y.). 310: 1793-6. PMID 16357255 DOI: 10.1126/science.1118919  1
2005 Shu CJ, Guo S, Kim YJ, Shelly SM, Nijagal A, Ray P, Gambhir SS, Radu CG, Witte ON. Visualization of a primary anti-tumor immune response by positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 102: 17412-7. PMID 16293690 DOI: 10.1073/pnas.0508698102  1
2005 Xin L, Lawson DA, Witte ON. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 6942-7. PMID 15860580 DOI: 10.1073/pnas.0502320102  1
2005 Wang L, Radu CG, Yang LV, Bentolila LA, Riedinger M, Witte ON. Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A. Molecular Biology of the Cell. 16: 2234-47. PMID 15728718 DOI: 10.1091/mbc.E04-12-1044  1
2005 Beillard E, Witte ON. Unraveling kinase signaling pathways with chemical genetic and chemical proteomic approaches. Cell Cycle (Georgetown, Tex.). 4: 434-7. PMID 15711120  1
2005 Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 1632-7. PMID 15665078 DOI: 10.1073/pnas.0409415102  1
2005 Witte ON, Kabarowski JH, Xu Y, Le LQ, Zhu K. Retraction. Science (New York, N.Y.). 307: 206. PMID 15653487 DOI: 10.1126/science.307.5707.206b  1
2005 Yang LV, Radu CG, Wang L, Riedinger M, Witte ON. Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood. 105: 1127-34. PMID 15383458 DOI: 10.1182/blood-2004-05-1916  1
2004 Wong S, McLaughlin J, Cheng D, Zhang C, Shokat KM, Witte ON. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proceedings of the National Academy of Sciences of the United States of America. 101: 17456-61. PMID 15505216 DOI: 10.1073/pnas.0407061101  0.96
2004 Kim YJ, Dubey P, Ray P, Gambhir SS, Witte ON. Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 6: 331-40. PMID 15380743 DOI: 10.1016/j.mibio.2004.06.009  1
2004 Guo S, Ferl GZ, Deora R, Riedinger M, Yin S, Kerwin JL, Loo JA, Witte ON. A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 14180-5. PMID 15375214 DOI: 10.1073/pnas.0405878101  1
2004 Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood. 104: 1281-90. PMID 15142874 DOI: 10.1182/blood-2003-09-3044  1
2004 Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annual Review of Immunology. 22: 247-306. PMID 15032571 DOI: 10.1146/annurev.immunol.22.012703.104753  1
2004 Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON, Fruman DA. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood. 103: 4268-75. PMID 14976048 DOI: 10.1182/blood-2003-07-2193  1
2004 Radu CG, Yang LV, Riedinger M, Au M, Witte ON. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proceedings of the National Academy of Sciences of the United States of America. 101: 245-50. PMID 14681556 DOI: 10.1073/pnas.2536801100  1
2003 Wong S, McLaughlin J, Cheng D, Shannon K, Robb L, Witte ON. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 11630-5. PMID 14500898 DOI: 10.1073/pnas.2035020100  0.96
2003 Ferl GZ, Timmerman JM, Witte ON. Extending the utility of gene profiling data by bridging microarray platforms. Proceedings of the National Academy of Sciences of the United States of America. 100: 10585-7. PMID 12963810 DOI: 10.1073/pnas.2034937100  1
2003 Xin L, Ide H, Kim Y, Dubey P, Witte ON. In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme. Proceedings of the National Academy of Sciences of the United States of America. 100: 11896-903. PMID 12909713 DOI: 10.1073/pnas.1734139100  1
2003 Dubey P, Su H, Adonai N, Du S, Rosato A, Braun J, Gambhir SS, Witte ON. Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 100: 1232-7. PMID 12547911 DOI: 10.1073/pnas.0337418100  0.48
2003 Wong S, McLaughlin J, Cheng D, Witte ON. Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood. 101: 4088-97. PMID 12521991 DOI: 10.1182/blood-2002-11-3376  1
2002 Ide H, Seligson DB, Memarzadeh S, Xin L, Horvath S, Dubey P, Flick MB, Kacinski BM, Palotie A, Witte ON. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 99: 14404-9. PMID 12381783 DOI: 10.1073/pnas.222537099  1
2002 Kabarowski JH, Xu Y, Witte ON. Lysophosphatidylcholine as a ligand for immunoregulation. Biochemical Pharmacology. 64: 161-7. PMID 12123735 DOI: 10.1016/S0006-2952(02)01179-6  1
2002 Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer Cell. 1: 381-91. PMID 12086852 DOI: 10.1016/S1535-6108(02)00058-2  1
2002 Wu JJ, Afar DE, Phan H, Witte ON, Lam KS. Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase. Combinatorial Chemistry & High Throughput Screening. 5: 83-91. PMID 11860343  1
2002 Era T, Wong S, Witte ON. Analysis of Bcr-Abl function using an in vitro embryonic stem cell differentiation system. Methods in Molecular Biology (Clifton, N.J.). 185: 83-95. PMID 11769015  1
2002 Fruman DA, Ferl GZ, An SS, Donahue AC, Satterthwaite AB, Witte ON. Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 359-64. PMID 11756681 DOI: 10.1073/pnas.012605099  1
2001 Wong S, Witte ON. Modeling Philadelphia chromosome positive leukemias. Oncogene. 20: 5644-59. PMID 11607816 DOI: 10.1038/sj.onc.1204638  1
2001 Kabarowski JH, Zhu K, Le LQ, Witte ON, Xu Y. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science (New York, N.Y.). 293: 702-5. PMID 11474113 DOI: 10.1126/science.1061781  1
2001 Le LQ, Kabarowski JH, Weng Z, Satterthwaite AB, Harvill ET, Jensen ER, Miller JF, Witte ON. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity. 14: 561-71. PMID 11371358 DOI: 10.1016/S1074-7613(01)00145-5  1
2001 Dubey P, Wu H, Reiter RE, Witte ON. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression Cancer Research. 61: 3256-3261. PMID 11309275  1
2000 Kabarowski JHS, Witte ON. Consequences of BCR-ABL expression within the hematopoietic stem cell in chronic myeloid leukemia Stem Cells. 18: 399-408. PMID 11072027  1
2000 Kabarowski JH, Feramisco JD, Le LQ, Gu JL, Luoh SW, Simon MI, Witte ON. Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement. Proceedings of the National Academy of Sciences of the United States of America. 97: 12109-14. PMID 11050239 DOI: 10.1073/pnas.97.22.12109  1
2000 Lim YM, Wong S, Lau G, Witte ON, Colicelli J. BCR/ABL inhibition by an escort/phosphatase fusion protein. Proceedings of the National Academy of Sciences of the United States of America. 97: 12233-8. PMID 11027300 DOI: 10.1073/pnas.210253497  1
2000 Satterthwaite AB, Witte ON. The role of Bruton's tyrosine kinase in B-cell development and function: A genetic perspective Immunological Reviews. 175: 120-127. PMID 10933597 DOI: 10.1034/j.1600-065X.2000.017504.x  1
2000 Fruman DA, Satterthwaite AB, Witte ON. Xid-like phenotypes: A B cell signalosome takes shape Immunity. 13: 1-3. PMID 10933389  1
2000 Era T, Witte ON. Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate Proceedings of the National Academy of Sciences of the United States of America. 97: 1737-1742. PMID 10677527 DOI: 10.1073/pnas.97.4.1737  1
1999 Saffran DC, Reiter RE, Jakobovits A, Witte ON. Target antigens for prostate cancer immunotherapy Cancer and Metastasis Reviews. 18: 437-449. PMID 10855787 DOI: 10.1023/A:1006333222424  1
1999 Nisitani S, Kato RM, Rawlings DJ, Witte ON, Wahl MI. In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies Proceedings of the National Academy of Sciences of the United States of America. 96: 2221-2226. PMID 10051622 DOI: 10.1073/pnas.96.5.2221  1
1999 Shi CS, Tuscano JM, Witte ON, Kehrl JH. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway Blood. 93: 1338-1345. PMID 9949177  1
1998 Mahlmann S, McLaughlin J, Afar DE, Mohr R, Kay RJ, Witte ON. Dissection of signaling pathways and cloning of new signal transducers in tyrosine kinase-induced pathways by genetic selection. Leukemia. 12: 1858-65. PMID 9844916  1
1998 Satterthwaite AB, Rawlings DJ, Witte ON. DSHP: A 'power bar' for sustained immune responses? Proceedings of the National Academy of Sciences of the United States of America. 95: 13355-13357. PMID 9811804 DOI: 10.1073/pnas.95.23.13355  1
1998 Weng Z, Fluckiger AC, Nisitani S, Wahl MI, Le LQ, Hunter CA, Fernal AA, Le Beau MM, Witte ON. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proceedings of the National Academy of Sciences of the United States of America. 95: 12334-9. PMID 9770487 DOI: 10.1073/pnas.95.21.12334  1
1998 Satterthwaite AB, Li Z, Witte ON. Btk function in B cell development and responsee Seminars in Immunology. 10: 309-316. PMID 9695187 DOI: 10.1006/smim.1998.0123  1
1998 Lieberman JR, Le LQ, Wu L, Finerman GA, Berk A, Witte ON, Stevenson S. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 16: 330-9. PMID 9671928 DOI: 10.1002/jor.1100160309  1
1997 Satterthwaite AB, Cheroutre H, Khan WN, Sideras P, Witte ON. Btk dosage determines sensitivity to B cell antigen receptor cross- linking Proceedings of the National Academy of Sciences of the United States of America. 94: 13152-13157. PMID 9371815 DOI: 10.1073/pnas.94.24.13152  1
1997 Li T, Rawlings DJ, Park H, Kato RM, Witte ON, Satterthwaite AB. Constitutive membrane association potentiates activation of Bruton tyrosine kinase Oncogene. 15: 1375-1383. PMID 9333013  1
1997 Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G. A functional screen for regulators of the c-Abl protein tyrosine kinase Leukemia. 11: 313-315. PMID 9209375  1
1997 Afar DE, Han L, McLaughlin J, Wong S, Dhaka A, Parmar K, Rosenberg N, Witte ON, Colicelli J. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Immunity. 6: 773-82. PMID 9208849  0.96
1996 Maru Y, Witte ON, Shibuya M. BCR-ABL induces neurite-like structures and BCR lacking the SH2-binding domain induces cell rounding in PC12 cells Experimental Cell Research. 229: 438-445. PMID 8986627 DOI: 10.1006/excr.1996.0389  1
1996 Satterthwaite AB, Witte ON. Lessons from human genetic variants in the study of B-cell differentiation Current Opinion in Immunology. 8: 454-458. PMID 8794006 DOI: 10.1016/S0952-7915(96)80029-X  1
1996 Maru Y, Afar DE, Witte ON, Shibuya M. The dimerization property of glutathione S-transferase partially reactivates Bcr-Abl lacking the oligomerization domain Journal of Biological Chemistry. 271: 15353-15357. PMID 8663064 DOI: 10.1074/jbc.271.26.15353  1
1996 Walkenhorst J, Goga A, Witte ON, Superti-Furga G. Analysis of human c-Abl tyrosine kinase activity and regulation in S.pombe Oncogene. 12: 1513-1520. PMID 8622867  1
1996 Maru Y, Witte ON, Shibuya M. Deletion of the ABL SH3 domain reactivates de-oligomerized BCR-ABL for growth factor independence Febs Letters. 379: 244-246. PMID 8603698 DOI: 10.1016/0014-5793(95)01518-3  1
1996 Wahl MI, Park H, Rawlings DJ, Witte ON. Regulation of Bruton's tyrosine kinase by phosphorylation Journal of Investigative Medicine. 44.  1
1995 Rawlings DJ, Witte ON. The Btk subfamily of cytoplasmic tyrosine kinases: Structure, regulation and function Seminars in Immunology. 7: 237-246. PMID 8520028  1
1995 Sawyers CL, McLaughlin J, Witte ON. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene Journal of Experimental Medicine. 181: 307-313. PMID 7807010 DOI: 10.1084/jem.181.1.307  1
1995 Afar DEH, Mclaughlin J, Sherr CJ, Witte ON, Roussel MF. Signaling by ABL oncogenes through cyclin D1 Proceedings of the National Academy of Sciences of the United States of America. 92: 9540-9544. PMID 7568169 DOI: 10.1073/pnas.92.21.9540  1
1995 Goga A, McLaughlin J, Afar DEH, Saffran DC, Witte ON. Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene Cell. 82: 981-988. PMID 7553858 DOI: 10.1016/0092-8674(95)90277-5  1
1995 Rawlings DJ, Quan SG, Kato RM, Witte ON. Long-term culture system for selective growth of human B-cell progenitors Proceedings of the National Academy of Sciences of the United States of America. 92: 1570-1574. PMID 7533295 DOI: 10.1073/pnas.92.5.1570  1
1995 Afar DEH, Witte ON. Characterization of breakpoint cluster region kinase and SH2-binding activities Methods in Enzymology. 256: 125-129. PMID 7476425 DOI: 10.1016/0076-6879(95)56017-3  1
1994 Afar DEH, Goga A, McLaughlin J, Witte ON, Sawyers CL. Differential complementation of Bcr-Abl point mutants with c-Myc Science. 264: 424-426. PMID 8153630  1
1994 Rawlings DJ, Witte ON. Bruton's tyrosine kinase is a key regulator in B-cell development Immunological Reviews. 105-119. PMID 8070812  1
1994 Tsukada S, Simon MI, Witte ON, Katz A. Binding of βγ subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase Proceedings of the National Academy of Sciences of the United States of America. 91: 11256-11260. PMID 7972043 DOI: 10.1073/pnas.91.23.11256  1
1994 Tsukada S, Rawlings DJ, Witte ON. Role of Bruton's tyrosine kinase in immunodeficiency Current Opinion in Immunology. 6: 623-630. PMID 7946052 DOI: 10.1016/0952-7915(94)90151-1  1
1994 Faust EA, Rawlings DJ, Saffran DC, Witte ON. Development of btk transgenic mice Current Topics in Microbiology and Immunology. 194: 363-370. PMID 7895510  1
1994 Tsukada S, Witte ON. X-linked agammaglobulinemia and Bruton's tyrosine kinase Advances in Experimental Medicine and Biology. 365: 233-238. PMID 7887309  1
1994 Kawakami Y, Yao L, Miura T, Tsukada S, Witte ON, Kawakami T. Tyrosine phosphorylation and activation of bruton tyrosine kinase upon FcεRI cross-linking Molecular and Cellular Biology. 14: 5108-5113. PMID 7518558  1
1994 Saffran DC, Witte ON. The molecular pathogenesis of XLA involves a spectrum of mutations in Bruton's tyrosine kinase Clinical Immunology Newsletter. 14: 69-77. DOI: 10.1016/0197-1859(94)90047-7  1
1993 Gishizky ML, Johnson-White J, Witte ON. Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia- like syndrome in mice Proceedings of the National Academy of Sciences of the United States of America. 90: 3755-3759. PMID 8475126  1
1993 Pendergast AM, Gishizky ML, Havlik MH, Witte ON. SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. Molecular and Cellular Biology. 13: 1728-36. PMID 8441409  1
1993 Clark SS, Chen E, Fizzotti M, Witte ON, Malkovska V. BCR-ABL and v-abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets Journal of Virology. 67: 6033-6046. PMID 8396667  1
1993 Gishizky ML, Johnson-White J, Witte ON. Evaluating the effect of P210 BCR/ABL on growth of hematopoietic progenitor cells and its role in the pathogenesis of human chronic myelogenous leukemia Seminars in Hematology. 30: 6-8. PMID 8235710  1
1993 Muller AJ, Pendergast AM, Parmar K, Havlik MH, Rosenberg N, Witte ON. En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. 90: 3457-61. PMID 7682703  1
1993 Faust EA, Saffran DC, Toksoz D, Williams DA, Witte ON. Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells Journal of Experimental Medicine. 177: 915-923. PMID 7681470  1
1992 Sawyers CL, Gishizky ML, Quan S, Golde DW, Witte ON. Propagation of human elastic myeloid leukemias in the SCID mouse Blood. 79: 2089-2098. PMID 1562735  1
1992 Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes Cell. 70: 901-910. PMID 1525828 DOI: 10.1016/0092-8674(92)90241-4  1
1992 Gishizky ML, Witte ON. BCR/ABL enhances growth of multipotent progenitor cells but does not block their differentiation potential in vitro Current Topics in Microbiology and Immunology. 182: 65-72. PMID 1490392  1
1992 Saffran DC, Faust EA, Witte ON. Establishment of a reproductive culture technique for the selective growth of B-cell progenitors Current Topics in Microbiology and Immunology. 182: 37-43. PMID 1490376  1
1992 Hart MJ, Maru Y, Leonard D, Witte ON, Evans T, Cerione RA. A GDP dissociation inhibitor that serves as a GTPase inhibitor for the ras-like protein CDC42HS Science. 258: 812-815. PMID 1439791  1
1992 Muller AJ, Pendergast AM, Havlik MH, Puil L, Pawson T, Witte ON. A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. Molecular and Cellular Biology. 12: 5087-93. PMID 1383690  1
1992 Gishizky ML, Witte ON. Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro Science. 256: 836-839. PMID 1375394  1
1991 Young JC, Gishizky ML, Witte ON. Hyperexpression of interleukin-7 is not necessary or sufficient for transformation of a pre-B lymphoid cell line. Molecular and Cellular Biology. 11: 854-63. PMID 1990288  1
1991 Sawyers CL, Denny CT, Witte ON. Leukemia and the disruption of normal hematopoiesis Cell. 64: 337-350. PMID 1988151  1
1991 Shah NP, Witte ON, Denny CT. Characterization of the BCR Promoter in Philadelphia Chromosome-Positive and -Negative Cell Lines Molecular and Cellular Biology. 11: 1854-1860. PMID 1900918  1
1991 Gishizky ML, McLaughlin J, Pendergast AM, Witte ON. The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells. Oncogene. 6: 1299-306. PMID 1886706  1
1991 Kelliher M, Knott A, McLaughlin J, Witte ON, Rosenberg N. Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene Molecular and Cellular Biology. 11: 4710-4716. PMID 1875948  1
1991 Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell. 66: 161-71. PMID 1712671 DOI: 10.1016/0092-8674(91)90148-R  1
1991 Maru Y, Witte ON. The BCR gene encodes a novel serine/threonine kinase activity within a single exon Cell. 67: 459-468. PMID 1657398  1
1990 Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science (New York, N.Y.). 247: 1079-82. PMID 2408149  1
1990 Scherle PA, Dorshkind K, Witte ON. Clonal lymphoid progenitor cell lines expressing the BCR/ABL oncogene retain full differentiative function Proceedings of the National Academy of Sciences of the United States of America. 87: 1908-1912. PMID 2408044  1
1990 Sawyers CL, Timson L, Kawasaki ES, Clark SS, Witte ON, Champlin R. Molecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America. 87: 563-7. PMID 2405384  1
1990 Witte ON. Steel locus defines new multipotent growth factor Cell. 63: 5-6. PMID 2208282 DOI: 10.1016/0092-8674(90)90280-R  1
1990 Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL Proceedings of the National Academy of Sciences of the United States of America. 87: 6649-6653. PMID 2204061  1
1990 Scherle PA, Witte ON. Functionality of clonal lymphoid progenitor cells expressing the P210 BCR/ABL oncogene Current Topics in Microbiology and Immunology. 166: 189-195. PMID 2073798  1
1990 Denis KA, Witte ON, Brinster RL, Provost S, Storb U. Delay of Early B-Lymphocyte Development By Gamma 2b Immunoglobulin Transgene: Effect on Differentiation- Specific Molecules Developmental Immunology. 1: 105-112. PMID 1967016 DOI: 10.1155/1990/71584  1
1989 McLaughlin J, Chianese E, Witte ON. Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells Molecular and Cellular Biology. 9: 1866-1874. PMID 2747638  1
1989 Gross Lugo T, Witte ON. The BCR-ABL oncogene transforms rat-1 cells and cooperates with v-myc Molecular and Cellular Biology. 9: 1263-1270. PMID 2725497  1
1989 Ponzetto C, Wadewitz AG, Pendergast AM, Witte ON, Wolgemuth DJ. P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. Oncogene. 4: 685-90. PMID 2660070  1
1989 Clark SS, Crist WM, Witte ON. Molecular pathogenesis of Ph-positive leukemias Annual Review of Medicine. 40: 113-122. PMID 2658742  1
1989 Timmons MS, Witte ON. Structural characterization of the BCR gene product Oncogene. 4: 559-567. PMID 2657572  1
1989 Muller AJ, Witte ON. The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation Molecular and Cellular Biology. 9: 5234-5238. PMID 2601719  1
1989 Pendergast AM, Clark R, Kawasaki ES, McCormick FP, Witte ON. Baculovirus expression of functional P210 BCR-ABL oncogene product. Oncogene. 4: 759-66. PMID 2499863  1
1989 Denis KA, Timson LK, Witte ON. V(H) repertoire in progeny of long term lymphoid-cultured cells used to reconstitute immunodeficient mice Journal of Immunology. 142: 2981-2987. PMID 2496157  1
1988 Young JC, Witte ON. Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures. Molecular and Cellular Biology. 8: 4079-87. PMID 3263566  1
1988 Witte ON. Closely related BCR/ABL oncogenes are associated with the distinctive clinical biologies of Philadelphia chromosome positive chronic myelogenous and acute lymphocytic leukemia Current Topics in Microbiology and Immunology. 141: 42-49. PMID 3063449  1
1988 Schwartz RC, Witte ON. A recombinant murine retrovirus expressing v-rel is cytopathic Virology. 165: 182-190. PMID 2838956 DOI: 10.1016/0042-6822(88)90671-X  1
1988 Schwartz RC, Witte ON. The role of multiple oncogenes in hematopoietic neoplasia Mutation Research/Reviews in Genetic Toxicology. 195: 245-253. PMID 2834641 DOI: 10.1016/0165-1110(88)90003-6  1
1988 Rosenberg N, Witte ON. the Viral and Cellular Forms of the Abelson (Dbl) Oncogene Advances in Virus Research. 35: 39-81. DOI: 10.1016/S0065-3527(08)60708-3  1
1987 Clark SS, Mclaughlin J, Crist WM, Champlin R, Witte ON. Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL Science. 235: 85-88. PMID 3541203  1
1987 Whitlock CA, Witte ON. Long-term culture of murine bone marrow precursors of B lymphocytes Methods in Enzymology. 150: 275-286. PMID 3501518  1
1987 McLaughlin J, Chianese E, Witte ON. In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome Proceedings of the National Academy of Sciences of the United States of America. 84: 6558-6562. PMID 3498165  1
1987 Denis KA, Dorshkind K, Witte ON. Regulated progression of B lymphocyte differentiation from cultured fetal liver Journal of Experimental Medicine. 166: 391-403. PMID 3496415  1
1987 Dorshkind K, Witte ON. Long-term murine hemopoietic cultures as model systems for analysis of B lymphocyte differentiation Current Topics in Microbiology and Immunology. 135: 23-41. PMID 3495412  1
1987 Denis KA, Witte ON. Long-term culture systems for analysis of early b lymphocyte development International Reviews of Immunology. 2: 285-305. PMID 3333784 DOI: 10.3109/08830188709044758  1
1987 Pendergast AM, Witte ON. Role of the ABL oncogene tyrosine kinase activity in human leukaemia. BaillièRe's Clinical Haematology. 1: 1001-20. PMID 3332851 DOI: 10.1016/S0950-3536(87)80036-7  1
1987 Mes-Masson AM, Witte ON. Role of the abl oncogene in chronic myelogenous leukemia Advances in Cancer Research. 49: 53-74. PMID 3314397  1
1987 Pendergast AM, Traugh JA, Witte ON. Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. Molecular and Cellular Biology. 7: 4280-9. PMID 3125421  1
1987 Daley GQ, McLaughlin J, Witte ON, Baltimore D. The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts Science. 237: 532-535. PMID 2440107  1
1987 Hunt P, Robertson D, Weiss D, Rennick D, Lee F, Witte ON. A single bone marrow-derived stromal cell type supports the in vitro growth of early lymphoid and myeloid cells Cell. 48: 997-1007. PMID 2435412 DOI: 10.1016/0092-8674(87)90708-2  1
1986 Schwartz RC, Stanton LW, Marcu KB, Witte ON. An in vitro model for tumor progression in murine lymphoid cells Current Topics in Microbiology and Immunology. 132: 75-80. PMID 3491739  1
1986 Witte ON. Functions of the abl oncogene Cancer Surveys. 5: 183-197. PMID 3465440  1
1986 Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science (New York, N.Y.). 233: 212-4. PMID 3460176  1
1986 Witte ON. Involvement of the abl oncogene in human chronic myelogenous leukemia Princess Takamatsu Symposia. 17: 143-149. PMID 3332006  1
1986 Ku G, Witte ON. Corticosteroid-resistant bone marrow-derived B lymphocyte progenitor for long term in vitro cultures Journal of Immunology. 137: 2802-2807. PMID 3093582  1
1986 Denis KA, Witte ON. In vitro development of B lymphocytes from long-term cultured precursor cells Proceedings of the National Academy of Sciences of the United States of America. 83: 441-445. PMID 3079911  1
1986 Schwartz RC, Stanton LW, Riley SC, Marcu KB, Witte ON. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells Molecular and Cellular Biology. 6: 3221-3231. PMID 3023969  1
1986 Schiff-Maker L, Burns MC, Konopka JB, Clark S, Witte ON, Rosenberg N. Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules Journal of Virology. 57: 1182-1186. PMID 3005619  1
1986 Dorshkind K, Denis KA, Witte ON. Lymphoid bone marrow cultures can reconstitute heterogenous B and T cell-dependent responses in severe combined immunodeficient mice Journal of Immunology. 137: 3457-3463. PMID 2878043  1
1986 Pillemer EA, Kooistra DA, Witte ON, Weissman IL. Monoclonal antibody to the amino-terminal L sequence of murine leukemia virus glycosylated gag polyproteins demonstrates their unusual orientation in the cell membrane Journal of Virology. 57: 413-421. PMID 2418213  1
1985 Davis RL, Konopka JB, Witte ON. Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties Molecular and Cellular Biology. 5: 204-213. PMID 4039028  1
1985 Storb U, Denis KA, Brinster RL, Witte ON. Pre-B cells in κ-transgenic mice Nature. 316: 356-358. PMID 3927171 DOI: 10.1038/316356a0  1
1985 Konopka JB, Witte ON. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products Molecular and Cellular Biology. 5: 3116-3123. PMID 3879812  1
1985 Konopka JB, Watanabe SM, Singer JW, Collins SJ, Witte ON. Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration Proceedings of the National Academy of Sciences of the United States of America. 82: 1810-1814. PMID 3856862 DOI: 10.1073/pnas.82.6.1810  1
1985 Konopka JB, Witte ON. Activation of the abl oncogene in murine and human leukemias Bba - Reviews On Cancer. 823: 1-17. PMID 2996602 DOI: 10.1016/0304-419X(85)90012-5  1
1985 Whitlock CA, Witte ON. The complexity of virus-cell interactions in Abelson virus infection of lymphoid and other hematopoietic cells Advances in Immunology. 74-98.  1
1984 Whitlock CA, Robertson D, Witte ON. Murine B cell lymphopoiesis in long term culture Journal of Immunological Methods. 67: 353-369. PMID 6608556 DOI: 10.1016/0022-1759(84)90475-7  1
1984 Denis KA, Treiman LJ, St. Claire JI, Witte ON. Long-term cultures of murine fetal liver retain very early B lymphoid phenotype Journal of Experimental Medicine. 160: 1087-1101. PMID 6434687  1
1984 Kurland JI, Ziegler SF, Witte ON. Long-term cultured B lymphocytes and their precursors reconstitute the B-lymphocyte lineage in vivo Proceedings of the National Academy of Sciences of the United States of America. 81: 7554-7558. PMID 6334312  1
1984 Kurland JI, Witte ON. Development of cells of the B-lymphocyte lineage in longterm culture Current Topics in Microbiology and Immunology. 113: 217-223. PMID 6332717  1
1984 Ziegler SF, Treiman LJ, Witte ON. kappa gene diversity among the clonal progeny of pre-B lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 81: 1529-1533. PMID 6324199  1
1984 Konopka JB, Watanabe SM, Witte ON. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity Cell. 37: 1035-1042. PMID 6204766 DOI: 10.1016/0092-8674(84)90438-0  1
1984 Watanabe SM, Rosenberg NE, Witte ON. A membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitro Journal of Virology. 51: 620-627. PMID 6088787  1
1984 Ziegler SF, Treiman LJ, Witte ON. ≃ gene diversity among the clonal progeny of pre-B lymphocytes Isotopenpraxis. 20: 1529-1533.  1
1983 Whitlock CA, Ziegler SF, Witte ON. Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes Molecular and Cellular Biology. 3: 596-604. PMID 6304498  1
1983 Witte ON. Molecular and cellular biology of Abelson virus transformation Current Topics in Microbiology and Immunology. 103: 127-146. PMID 6303708  1
1983 Watanabe SM, Witte ON. Site-directed deletions of Abelson murine leukemia virus define 3' sequences essential for transformation and lethality Journal of Virology. 45: 1028-1036. PMID 6300444  1
1983 Whitlock CA, Ziegler SF, Treiman LJ, Stafford JI, Witte ON. Differentiation of cloned populations of immature B cells after transformation with abelson murine leukemia virus Cell. 32: 903-911. PMID 6299581 DOI: 10.1016/0092-8674(83)90075-2  1
1982 Whitlock CA, Witte ON. Long-term culture of B lymphocytes and their precursors from murine bone marrow Proceedings of the National Academy of Sciences of the United States of America. 79: 3608-3612. PMID 6980414  1
1982 Ponticelli AS, Whitlock CA, Rosenberg N, Witte ON. In vivo tyrosine phosphorylations of the abelson virus transforming protein are absent in its normal cellular homolog Cell. 29: 953-960. PMID 6185233 DOI: 10.1016/0092-8674(82)90458-5  1
1981 Whitlock CA, Witte ON. Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential Journal of Virology. 40: 577-584. PMID 6275106  1
1981 Witte ON, Ponticelli A, Gifford A, Baltimore D, Rosenberg N, Elder J. Phosphorylation of the Abelson murine leukemia virus transforming protein Journal of Virology. 39: 870-878. PMID 6270355  1
1981 Goff SP, Witte ON, Gilboa E, Rosenberg N, Baltimore D. Genome structure of Abelson murine leukemia virus variants: proviruses in fibroblasts and lymphoid cells. Journal of Virology. 38: 460-8. PMID 6264122  1
1981 Ziegler SF, Whitlock CA, Goff SP, Gifford A, Witte ON. Lethal effect of the abelson murine leukemia virus transforming gene product Cell. 27: 477-486. PMID 6101202 DOI: 10.1016/0092-8674(81)90389-5  1
1980 Silverstone A, Sun L, Witte ON, Baltimore D. Biosynthesis of murine terminal deoxynucleotidyltransferase Journal of Biological Chemistry. 255: 791-796. PMID 7356645  1
1980 Rosenberg NE, Clark DR, Witte ON. Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation Journal of Virology. 36: 766-774. PMID 6257926  1
1980 Goff SP, Gilboa E, Witte ON, Baltimore D. Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell. 22: 777-85. PMID 6257398 DOI: 10.1016/0092-8674(80)90554-1  1
1980 Witte ON, Rosenberg N, Baltimore D. Gene expression of Abelson murine leukemia virus Progress in Clinical and Biological Research. 41: 757-764. PMID 6256775  1
1980 Witte ON, Goff S, Rosenberg N, Baltimore D. A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 77: 4993-7. PMID 6254050  1
1980 Rosenberg N, Witte ON. Abelson murine leukemia virus mutants with alterations in the virus specific P120 molecule Journal of Virology. 33: 340-348. PMID 6245237  1
1980 Witte ON, Dasgupta A, Baltimore D. Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine Nature. 283: 826-831. PMID 6244493 DOI: 10.1038/283826a0  1
1980 Rotter V, Witte ON, Coffman R, Baltimore D. Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50 Journal of Virology. 36: 547-555. PMID 6159484  1
1979 Rosenberg N, Witte ON, Baltimore D. Characterization of Abelson murine leukemia virus isolates differing in P120 expression Symposia On Quantitative Biology. 44: 859-864. PMID 6253219  1
1979 Witte ON, Sun L, Rosenberg N, Baltimore D. A trans-acting protein kinase identified in cells transformed by Abelson murine leukemia virus Symposia On Quantitative Biology. 44: 855-857. PMID 6253218  1
1979 Witte ON, Wirth DF. Structure of the murine leukemia virus envelope glycoprotein precursor Journal of Virology. 29: 735-743. PMID 430608  1
1979 Baltimore D, Rosenberg N, Witte ON. Transformation of immature lymphoid cells by Abelson murine leukemia virus Immunological Reviews. 48: 3-22. PMID 397920  1
1979 Witte ON, Rosenberg N, Baltimore D. Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface Journal of Virology. 31: 776-784. PMID 92572  1
1979 Witte ON, Rosenberg NE, Baltimore D. A normal cell protein cross-reactive to the major Abelson murine leukaemia virus gene product Nature. 281: 396-398. PMID 90344  1
1979 Witte ON, Rosenberg NE, Baltimore D. A normal cell protein cross-Reactive to the major Abelson murine leukaemia virus gene product [22] Nature. 281: 369-398. DOI: 10.1038/281396a0  1
1978 Witte ON, Rosenberg N, Paskind M, Shields A, Baltimore D. Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells Proceedings of the National Academy of Sciences of the United States of America. 75: 2488-2492. PMID 209468  1
1978 Hale AH, Witte ON, Baltimore D, Eisen HN. Vesicular stomatitis virus glycoprotein is necessary for H 2 restricted lysis of infected cells by cytotoxic T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 75: 970-974. PMID 204941  1
1978 Shields A, Witte ON, Rothenberg E, Baltimore D. High frequency of aberrant expression of moloney murine leukemia virus in clonal infections Cell. 14: 601-609. PMID 80281 DOI: 10.1016/0092-8674(78)90245-3  1
1978 Witte ON, Baltimore D. Relationship of retrovirus polyprotein cleavages to virion maturation studied with temperature-sensitive murine leukemia virus mutants Journal of Virology. 26: 750-761. PMID 78989  1
1977 Witte ON, Baltimore D. Mechanism of formation of pseudotypes between vesicular stomatitis virus and murine leukemia virus Cell. 11: 505-511. PMID 195740 DOI: 10.1016/0092-8674(77)90068-X  1
1977 Witte ON, Tsukamoto-Adey A, Weissman IL. Cellular maturation of oncornavirus glycoproteins: Topological arrangement of precursor and product forms in cellular membranes Virology. 76: 539-553. PMID 190766 DOI: 10.1016/0042-6822(77)90236-7  1
1976 Witte ON, Weissman IL. Oncornavirus budding: Kinetics of formation and utilization of viral membrane glycoprotein Virology. 69: 464-473. PMID 176781 DOI: 10.1016/0042-6822(76)90477-3  1
1974 Witte ON, Weissman IL. Membrane proteins of MSV-MLV: Their role in virion-virion interactions in vitro Virology. 61: 588-593. PMID 4371500 DOI: 10.1016/0042-6822(74)90292-X  1
1974 Witte ON, Weissman IL. Polypeptides of Moloney sarcoma-leukemia virions: Their resolution and incorporation into extracellular virions Virology. 61: 575-587. PMID 4371461 DOI: 10.1016/0042-6822(74)90291-8  1
1973 Witte ON, Weissman IL, Kaplan HS. Structural characteristics of some murine RNA tumor viruses studied by lactoperoxidase iodination Proceedings of the National Academy of Sciences of the United States of America. 70: 36-40. PMID 4346036  1
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