Owen N. Witte - Publications

Affiliations: 
Molecular Biology 0573 University of California, Los Angeles, Los Angeles, CA 
Area:
Molecular Biology, Oncology

336 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Varuzhanyan G, Chen CC, Freeland J, He T, Tran W, Song K, Wang L, Cheng D, Xu S, Dibernardo GA, Esedebe FN, Abt ER, Park JW, Memarzadeh S, Graeber T, ... ... Witte O, et al. PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity. Biorxiv : the Preprint Server For Biology. PMID 38645232 DOI: 10.1101/2024.04.09.588489  0.65
2023 Chen CC, Tran W, Song K, Sugimoto T, Obusan MB, Wang L, Sheu KM, Cheng D, Ta L, Varuzhanyan G, Huang A, Xu R, Zeng Y, Borujerdpur A, Bayley NA, ... ... Witte ON, et al. Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation. Cancer Cell. PMID 37995683 DOI: 10.1016/j.ccell.2023.10.009  0.335
2023 Pan Y, Phillips JW, Zhang BD, Noguchi M, Kutschera E, McLaughlin J, Nesterenko PA, Mao Z, Bangayan NJ, Wang R, Tran W, Yang HT, Wang Y, Xu Y, Obusan MB, ... ... Witte ON, et al. IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221116120. PMID 37192158 DOI: 10.1073/pnas.2221116120  0.385
2021 Nesterenko PA, McLaughlin J, Tsai BL, Burton Sojo G, Cheng D, Zhao D, Mao Z, Bangayan NJ, Obusan MB, Su Y, Ng RH, Chour W, Xie J, Li YR, Lee D, ... ... Witte ON, et al. HLA-A02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses. Cell Reports. 110167. PMID 34919800 DOI: 10.1016/j.celrep.2021.110167  0.711
2021 Li YR, Zhou Y, Kim YJ, Zhu Y, Ma F, Yu J, Wang YC, Chen X, Li Z, Zeng S, Wang X, Lee D, Ku J, Tsao T, Hardoy C, ... ... Witte O, et al. Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Reports. Medicine. 2: 100449. PMID 34841295 DOI: 10.1016/j.xcrm.2021.100449  0.477
2020 Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, ... ... Witte O, et al. The DNA methylation landscape of advanced prostate cancer. Nature Genetics. PMID 32661416 DOI: 10.1038/S41588-020-0648-8  0.343
2020 VanDeusen HR, Ramroop JR, Morel KL, Bae S, Sheahan AV, Sychev Z, Lau NA, Cheng LC, Tan VM, Li Z, Petersen A, Lee JK, Park JW, Yang R, Hwang JH, ... ... Witte ON, et al. Targeting RET Kinase in Neuroendocrine Prostate Cancer. Molecular Cancer Research : McR. PMID 32461304 DOI: 10.1158/1541-7786.Mcr-19-1245  0.45
2020 Alumkal JJ, Sun D, Lu E, Beer TM, Thomas GV, Latour E, Aggarwal R, Cetnar J, Ryan CJ, Tabatabaei S, Bailey S, Turina CB, Quigley DA, Guan X, Foye A, ... ... Witte ON, et al. Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance. Proceedings of the National Academy of Sciences of the United States of America. PMID 32424106 DOI: 10.1073/Pnas.1922207117  0.358
2020 Phillips JW, Pan Y, Tsai BL, Xie Z, Demirdjian L, Xiao W, Yang HT, Zhang Y, Lin CH, Cheng D, Hu Q, Liu S, Black DL, Witte ON, Xing Y. Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 32086391 DOI: 10.1073/Pnas.1915975117  0.366
2020 Small EJ, Zhao S, Chen WS, Li H, Foye A, Sjöström M, Hua JJ, Aggarwal RR, Alumkal JJ, Beer TM, Gleave M, Rettig M, Witte O, Lara P, Chinnaiyan A, et al. The comprehensive methylation landscape of metastatic castration-resistant prostate cancer (mCRPC) identifies new phenotypic subtypes: Results from the West Coast Prostate Cancer Dream Team (WCDT). Journal of Clinical Oncology. 38: 5507-5507. DOI: 10.1200/Jco.2020.38.15_Suppl.5507  0.322
2019 Wang L, Smith BA, Balanis NG, Tsai BL, Nguyen K, Cheng MW, Obusan MB, Esedebe FN, Patel SJ, Zhang H, Clark PM, Sisk AE, Said JW, Huang J, Graeber TG, ... Witte ON, et al. A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871155 DOI: 10.1073/Pnas.1915770117  0.366
2019 Li Y, He Y, Butler W, Xu L, Chang Y, Lei K, Zhang H, Zhou Y, Gao AC, Zhang Q, Taylor DG, Cheng D, Farber-Katz S, Karam R, Landrith T, ... ... Witte ON, et al. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer. Science Translational Medicine. 11. PMID 31801883 DOI: 10.1126/Scitranslmed.Aax0428  0.628
2019 Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, ... ... Witte ON, et al. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. PMID 31495780 DOI: 10.1016/J.Stem.2019.08.004  0.535
2019 Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, ... ... Witte ON, et al. Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Reports. 28: 2728-2738.e7. PMID 31484081 DOI: 10.1016/J.Celrep.2019.07.106  0.733
2019 Balanis NG, Sheu KM, Esedebe FN, Patel SJ, Smith BA, Park JW, Alhani S, Gomperts BN, Huang J, Witte ON, Graeber TG. Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. Cancer Cell. 36: 17-34.e7. PMID 31287989 DOI: 10.1016/J.Ccell.2019.06.005  0.372
2019 Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, De Hoedt AM, Stuart J, Goldstein T, Chi K, ... ... Witte ON, et al. MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer. Prostate Cancer and Prostatic Diseases. PMID 30804427 DOI: 10.1038/S41391-019-0134-5  0.375
2019 Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, et al. T cell antigen discovery via trogocytosis. Nature Methods. 16: 183-190. PMID 30700903 DOI: 10.1038/S41592-018-0305-7  0.798
2019 Smith BA, Balanis NG, Tsai B, Park J, Zhang H, Said JW, Graeber TG, Witte ON, Chin* AI. MP57-09 MOLECULAR PROFILING OF SMALL CELL BLADDER CANCER: IMPLICATIONS FOR IMMUNOTHERAPEUTIC STRATEGIES Journal of Urology. 201. DOI: 10.1097/01.Ju.0000556626.19138.D3  0.344
2018 Puig-Saus C, Parisi G, Garcia-Diaz A, Krystofinski PE, Sandoval S, Zhang R, Champhekar AS, McCabe J, Cheung-Lau GC, Truong NA, Vega-Crespo A, Komenan MDS, Pang J, Macabali MH, Saco JD, ... ... Witte ON, et al. IND-enabling studies for a clinical trial to genetically program a persistent cancer-targeted immune system. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30409823 DOI: 10.1158/1078-0432.Ccr-18-0963  0.587
2018 Bethune MT, Li XH, Yu J, McLaughlin J, Cheng D, Mathis C, Moreno BH, Woods K, Knights AJ, Garcia-Diaz A, Wong S, Hu-Lieskovan S, Puig-Saus C, Cebon J, Ribas A, ... ... Witte ON, et al. Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348802 DOI: 10.1073/Pnas.1810653115  0.57
2018 Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, ... ... Witte O, et al. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 175: 889. PMID 30340047 DOI: 10.1016/J.Cell.2018.10.019  0.345
2018 Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science (New York, N.Y.). 362: 91-95. PMID 30287662 DOI: 10.1126/Science.Aat5749  0.425
2018 Smith BA, Balanis NG, Nanjundiah A, Sheu KM, Tsai BL, Zhang Q, Park JW, Thompson M, Huang J, Witte ON, Graeber TG. A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers. Cell Reports. 24: 3353-3366.e5. PMID 30232014 DOI: 10.1016/J.Celrep.2018.08.062  0.402
2018 Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, ... ... Witte O, et al. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. PMID 30033370 DOI: 10.1016/J.Cell.2018.06.039  0.375
2018 Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, et al. Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2017776880. PMID 29985747 DOI: 10.1200/Jco.2017.77.6880  0.36
2018 Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 29686080 DOI: 10.1073/Pnas.1802354115  0.827
2017 Park JW, Lee JK, Witte ON, Huang J. FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 28621319 DOI: 10.1038/Modpathol.2017.44  0.42
2017 Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1 pre-B ALL. The Journal of Experimental Medicine. 214: 793-814. PMID 28190001 DOI: 10.1084/Jem.20160049  0.587
2016 Aggarwal R, Beer TM, Gleave M, Stuart JM, Rettig M, Evans CP, Youngren J, Alumkal JJ, Huang J, Thomas G, Witte O, Small EJ. Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team. European Urology Focus. 2: 469-471. PMID 28723508 DOI: 10.1016/J.Euf.2016.10.011  0.38
2016 Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, ... ... Witte ON, et al. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Reports. 17: 2596-2606. PMID 27926864 DOI: 10.1016/J.Celrep.2016.11.010  0.708
2016 Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, ... ... Witte ON, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27694579 DOI: 10.1073/Pnas.1614529113  0.62
2016 Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, ... ... Witte ON, et al. Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. PMID 27499020 DOI: 10.1016/J.Cell.2016.07.007  0.402
2016 McCracken MN, Tavaré R, Witte ON, Wu AM. Advances in PET Detection of the Antitumor T Cell Response. Advances in Immunology. 131: 187-231. PMID 27235684 DOI: 10.1016/Bs.Ai.2016.02.004  0.338
2016 Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, ... Witte ON, et al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 29: 536-47. PMID 27050099 DOI: 10.1016/J.Ccell.2016.03.001  0.414
2016 Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044116 DOI: 10.1073/Pnas.1603645113  0.474
2016 Kim W, Le TM, Wei L, Poddar S, Bazzy J, Wang X, Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D, Gipson RM, Slavik R, Cabebe AE, ... ... Witte ON, et al. [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035974 DOI: 10.1073/Pnas.1524212113  0.303
2016 Small EJ, Aggarwal RR, Huang J, Sokolov A, Zhang L, Alumkal JJ, Youngren J, Ryan CJ, Foye A, Reiter RE, Evans CP, Gleave M, Witte O, Stuart J, Goldstein TC, et al. Clinical and genomic characterization of metastatic small cell/neuroendocrine prostate cancer (SCNC) and intermediate atypical prostate cancer (IAC): Results from the SU2C/PCF/AACRWest Coast Prostate Cancer Dream Team (WCDT). Journal of Clinical Oncology. 34: 5019-5019. DOI: 10.1200/Jco.2016.34.15_Suppl.5019  0.378
2016 Lin S, Stonyanova T, Kono E, Matsuura J, Kobayashi N, Yamashiro J, Hong D, Witte ON, Goldstein AS, Reiter RE. Abstract LB-279: N-cadherin promotes castration-resistant prostate cancer progression by enhancing stem cell properties of prostate cancer cells Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-279  0.645
2016 Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Stoyanova T, Faltermeier CM, Carlin DE, Vashisht A, Huang J, Wohlschlegel JA, Graeber TG, Witte ON, Stuart JM. Abstract 3882: Patient-specific druggable networks in lethal prostate cancer through proteome-guided multi-omic integration Cancer Research. 76: 3882-3882. DOI: 10.1158/1538-7445.Am2016-3882  0.403
2015 Zong Y, Goldstein AS, Witte ON. Tissue Recombination Models for the Study of Epithelial Cancer. Cold Spring Harbor Protocols. 2015: pdb.top069880. PMID 26631129 DOI: 10.1101/Pdb.Top069880  0.615
2015 Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26621741 DOI: 10.1073/Pnas.1521674112  0.428
2015 Tavare R, Escuin-Ordinas H, Mok S, McCracken MN, Zettlitz KA, Salazar FB, Witte ON, Ribas A, Wu AM. An effective immuno-PET imaging method to monitor CD8-dependent responses to immunotherapy. Cancer Research. PMID 26573799 DOI: 10.1158/0008-5472.Can-15-1707  0.317
2015 Sharma A, Sebastiano V, Scott CT, Magnus D, Koyano-Nakagawa N, Garry DJ, Witte ON, Nakauchi H, Wu JC, Weissman IL, Wu SM. Lift NIH restrictions on chimera research. Science (New York, N.Y.). 350: 640. PMID 26542560 DOI: 10.1126/Science.350.6261.640-A  0.445
2015 Zong Y, Goldstein AS, Witte ON. Dissociated Prostate Regeneration under the Renal Capsule. Cold Spring Harbor Protocols. 2015: pdb.prot078063. PMID 26527760 DOI: 10.1101/Pdb.Prot078063  0.616
2015 Zong Y, Goldstein AS, Witte ON. Preparation of Urogenital Sinus Mesenchymal Cells for Prostate Tissue Recombination Models. Cold Spring Harbor Protocols. 2015: pdb.prot078055. PMID 26527759 DOI: 10.1101/Pdb.Prot078055  0.646
2015 Smith BA, Sokolov A, Uzunangelov V, Baertsch R, Newton Y, Graim K, Mathis C, Cheng D, Stuart JM, Witte ON. A basal stem cell signature identifies aggressive prostate cancer phenotypes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26460041 DOI: 10.1073/Pnas.1518007112  0.467
2015 Evdokimov NM, Clark PM, Flores G, Chai T, Faull KF, Phelps ME, Witte ON, Jung ME. Development of 2-Deoxy-2-[(18)F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. Journal of Medicinal Chemistry. 58: 5538-47. PMID 26102222 DOI: 10.1021/Acs.Jmedchem.5B00569  0.764
2015 Tavare R, McCracken MN, Zettlitz KA, Salazar FB, Olafsen T, Witte ON, Wu AM. ImmunoPET of murine T cell reconstitution post-adoptive stem cell transplant using anti-CD4 and anti-CD8 cys-diabodies. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 25952734 DOI: 10.2967/Jnumed.114.153338  0.303
2015 McCracken MN, Vatakis DN, Dixit D, McLaughlin J, Zack JA, Witte ON. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. The Journal of Clinical Investigation. 125: 1815-26. PMID 25822024 DOI: 10.1172/Jci77326  0.395
2015 Smith DJ, Liu S, Ji S, Li B, McLaughlin J, Cheng D, Witte ON, Yang L. Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 1523-8. PMID 25605948 DOI: 10.1073/Pnas.1424877112  0.523
2015 Aggarwal RR, Thomas G, Youngren J, Foye A, Olson S, Paris P, Beer TM, Ryan CJ, Witte O, Evans CP, Gleave ME, Stuart J, Alumkal JJ, Toschi A, Zona N, et al. Androgen receptor (AR) amplification in patients (pts) with metastatic castration resistant prostate cancer (mCRPC) resistant to abiraterone (Abi) and enzalutamide (Enz): Preliminary results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT). Journal of Clinical Oncology. 33: 5068-5068. DOI: 10.1200/Jco.2015.33.15_Suppl.5068  0.316
2015 Youngren JF, Foye A, Thomas G, Stuart JM, Goldstein T, Robert B, Bivol A, Sokolov A, Ryan CJ, Pourmand N, Beer TM, Evans CP, Lara P, Gleave ME, Chi KN, ... ... Witte O, et al. Abstract A12: Identification of pathways associated with abiraterone resistance in metastatic castration resistant prostate cancer: Preliminary results from the SU2C/AACR West Coast Prostate Cancer Dream Team Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Pms14-A12  0.363
2015 Lee JK, Smith BA, Phillips JW, Park J, Stoyanova TI, Baertsch R, Sokolov A, Mathis C, Cheng D, Stuart JM, Huang J, Witte ON. Abstract A28: N-Myc drives small cell neuroendocrine cancer initiated from human prostate basal cells Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-A28  0.456
2015 Faltermeier C, Drake J, Clark P, Smith B, Mathis C, Zong Y, Volpe C, Witte O. Abstract 5183: Identification and characterization of wild type kinases driving prostate cancer metastasis Cancer Research. 75: 5183-5183. DOI: 10.1158/1538-7445.Am2015-5183  0.391
2015 Stoyanova T, Faltermeier C, Smith B, Goldstein A, Zhang X, Drake J, Lee J, Orellana S, Blum S, Cheng D, Pienta K, Huang J, Witte O. Abstract 4985: Notch1 as a key mediator in promoting advanced castration-resistant prostate cancer Cancer Research. 75: 4985-4985. DOI: 10.1158/1538-7445.Am2015-4985  0.612
2014 Small EJ, Youngren J, Alumkal J, Evans C, Ryan CJ, Lara P, Beer T, Witte O, Baertsch R, Stuart J. 760PDNEUROENDOCRINE PROSTATE CANCER (NEPC) IN PATIENTS (PTS) WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER (MCRPC) RESISTANT TO ABIRATERONE (ABI) OR ENZALUTAMIDE (ENZ): PRELIMINARY RESULTS FROM THE SU2C/PCF/AACR WEST COAST PROSTATE CANCER DREAM TEAM (WCDT). Annals of Oncology : Official Journal of the European Society For Medical Oncology. 25: iv258. PMID 28172078 DOI: 10.1093/Annonc/Mdu336.8  0.338
2014 Bunimovich YL, Nair-Gill E, Riedinger M, McCracken MN, Cheng D, McLaughlin J, Radu CG, Witte ON. Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. Plos One. 9: e104125. PMID 25101980 DOI: 10.1371/Journal.Pone.0104125  0.745
2014 Gschweng EH, McCracken MN, Kaufman ML, Ho M, Hollis RP, Wang X, Saini N, Koya RC, Chodon T, Ribas A, Witte ON, Kohn DB. HSV-sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice. Cancer Research. 74: 5173-83. PMID 25038231 DOI: 10.1158/0008-5472.Can-14-0376  0.431
2014 Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON. Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proceedings of the National Academy of Sciences of the United States of America. 111: E2866-74. PMID 24982199 DOI: 10.1073/Pnas.1410326111  0.765
2014 Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, ... ... Witte ON, et al. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2457-65. PMID 24634374 DOI: 10.1158/1078-0432.Ccr-13-3017  0.584
2014 Drake JM, Lee JK, Witte ON. Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer. Molecular and Cellular Biology. 34: 1722-32. PMID 24567371 DOI: 10.1128/Mcb.01592-13  0.346
2014 Tavaré R, McCracken MN, Zettlitz KA, Knowles SM, Salazar FB, Olafsen T, Witte ON, Wu AM. Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 1108-13. PMID 24390540 DOI: 10.1073/Pnas.1316922111  0.321
2014 Small EJ, Youngren J, Beer TM, Ryan CJ, Thomas G, Pourmand N, Reiter RE, Alumkal JJ, Stuart JM, Evans CP, Gleave ME, Chi KN, Toschi A, Foye A, Lara P, ... Witte O, et al. The molecular and pathway characterization of patients with metastatic castration resistant prostate cancer (mCRPC) refractory to therapy with abiraterone acetate or enzalutamide: Preliminary results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT). Journal of Clinical Oncology. 32: 79-79. DOI: 10.1200/Jco.2014.32.4_Suppl.79  0.374
2014 Thomas G, Youngren J, Ryan CJ, Beer TM, Gleave ME, Evans CP, Stuart J, Rettig M, Toschi A, Foye A, Alumkal JJ, Corless CL, Neff T, Baertsch R, Huang J, ... ... Witte O, et al. Molecular profiling of metastatic castration-resistant prostate cancer (mCRPC): Preliminary results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT). Journal of Clinical Oncology. 32: 5088-5088. DOI: 10.1200/Jco.2014.32.15_Suppl.5088  0.343
2014 Bivol A, Baertsch R, Sokolov A, Paull E, Newton Y, Goldstein TC, Foye A, Pourmand N, Youngren J, Parulkar R, Lopez A, de Vere White R, Alumkal JJ, Toschi A, Beer TM, ... ... Witte O, et al. Pathway-based signature analysis of RNA-seq data to reveal new targetable avenues for metastatic castration-resistant prostate cancer (mCRPC) patients (pts): Preliminary results from the SU2C/PCF/AACR West Coast Prostate Cancer Dream Team (WCDT). Journal of Clinical Oncology. 32: 11078-11078. DOI: 10.1200/Jco.2014.32.15_Suppl.11078  0.361
2014 Witte ON. Abstract SY13-03: Signal pathways in prostate cancer stem cells Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy13-03  0.466
2014 Lin S, Kono E, Yamashiro J, Lee S, Witte O, Goldstein A, Reiter RE. Abstract 3021: Roles of EMT on stem cell properties of prostate stem and cancer cells during castration-resistant prostate cancer progression Cancer Research. 74: 3021-3021. DOI: 10.1158/1538-7445.Am2014-3021  0.654
2014 Zangle TA, Burnes D, Mathis C, Witte ON, Teitell MA. High-Throughput Screening of T Cell Cytotoxic Events by Biomass Profiling Biophysical Journal. 106: 811a. DOI: 10.1016/J.Bpj.2013.11.4449  0.384
2013 Stoyanova T, Cooper AR, Drake JM, Liu X, Armstrong AJ, Pienta KJ, Zhang H, Kohn DB, Huang J, Witte ON, Goldstein AS. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 20111-6. PMID 24282295 DOI: 10.1073/Pnas.1320565110  0.661
2013 Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CM, Sud S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proceedings of the National Academy of Sciences of the United States of America. 110: E4762-9. PMID 24248375 DOI: 10.1073/Pnas.1319948110  0.418
2013 Janzen DM, Paik DY, Rosales MA, Yep B, Cheng D, Witte ON, Kayadibi H, Ryan CM, Jung ME, Faull K, Memarzadeh S. Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Molecular Cancer Therapeutics. 12: 2917-28. PMID 24222661 DOI: 10.1158/1535-7163.Mct-13-0572  0.65
2013 Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nature Immunology. 14: 1073-83. PMID 24013668 DOI: 10.1038/Ni.2707  0.56
2013 Zangle TA, Burnes D, Mathis C, Witte ON, Teitell MA. Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity. Plos One. 8: e68916. PMID 23935904 DOI: 10.1371/Journal.Pone.0068916  0.358
2013 Goldstein AS, Witte ON. Does the microenvironment influence the cell types of origin for prostate cancer? Genes & Development. 27: 1539-44. PMID 23873937 DOI: 10.1101/Gad.222380.113  0.645
2013 Smith DA, Kiba A, Zong Y, Witte ON. Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues. Molecular Cancer Research : McR. 11: 1159-65. PMID 23867565 DOI: 10.1158/1541-7786.Mcr-13-0238  0.4
2013 Janzen DM, Rosales MA, Paik DY, Lee DS, Smith DA, Witte ON, Iruela-Arispe ML, Memarzadeh S. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer Research. 73: 4697-710. PMID 23744837 DOI: 10.1158/0008-5472.Can-13-0930  0.649
2013 Ma C, Cheung AF, Chodon T, Koya RC, Wu Z, Ng C, Avramis E, Cochran AJ, Witte ON, Baltimore D, Chmielowski B, Economou JS, Comin-Anduix B, Ribas A, Heath JR. Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy. Cancer Discovery. 3: 418-29. PMID 23519018 DOI: 10.1158/2159-8290.Cd-12-0383  0.531
2013 Giannoni F, Hardee CL, Wherley J, Gschweng E, Senadheera S, Kaufman ML, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte ON, Economou JS, Ribas A, et al. Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1044-54. PMID 23380815 DOI: 10.1038/Mt.2013.8  0.519
2013 Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem Cells (Dayton, Ohio). 31: 808-22. PMID 23341289 DOI: 10.1002/Stem.1337  0.732
2013 McCracken MN, Gschweng EH, Nair-Gill E, McLaughlin J, Cooper AR, Riedinger M, Cheng D, Nosala C, Kohn DB, Witte ON. Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene. Proceedings of the National Academy of Sciences of the United States of America. 110: 1857-62. PMID 23319634 DOI: 10.1073/Pnas.1221840110  0.766
2013 Gschweng EH, McCracken MN, Chodon T, Koya RC, Kaufman ML, Ho M, Saini N, Hollis RP, Ribas A, De Oliveira SN, Witte ON, Kohn DB. A Pre-Clinical Model Of Hematopoietic Stem Cell Based Immunotherapy For Cancer Utilizing The NY-ESO-1 T-Cell Receptor and sr39TK PET Reporter / Suicide Gene Blood. 122: 2020-2020. DOI: 10.1182/Blood.V122.21.2020.2020  0.424
2013 Paik DY, Rosales M, Janzen D, Yep B, Cheng D, Witte O, Kayadibi H, Faull K, Memarzadeh S. Abstract 5539: Low levels of estrogen sensitize PTEN-deficient endometrial tumors to poly-ADP ribose polymerase (PARP) inhibitionin vivo. Cancer Research. 73: 5539-5539. DOI: 10.1158/1538-7445.Am2013-5539  0.648
2013 Janzen DM, Rosales MA, Paik DY, Smith DA, Cheng D, Witte ON, Iruela-Arispe L, Memarzadeh S. Abstract 4964: Signaling through the progesterone receptor in the tumor microenvironment regulates hormonal sensitivity in endometrial carcinoma. Cancer Research. 73: 4964-4964. DOI: 10.1158/1538-7445.Am2013-4964  0.653
2012 Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discovery. 2: 1109-17. PMID 23230188 DOI: 10.1158/2159-8290.Cd-12-0197  0.358
2012 Zong Y, Huang J, Sankarasharma D, Morikawa T, Fukayama M, Epstein JI, Chada KK, Witte ON. Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: E3395-404. PMID 23184966 DOI: 10.1073/Pnas.1217982109  0.439
2012 Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. The Journal of Experimental Medicine. 209: 2215-28. PMID 23148236 DOI: 10.1084/Jem.20121061  0.31
2012 Goldstein AS, Witte ON. A plethora of progenitors in the post-natal prostate. Embo Reports. 13: 1036-7. PMID 23138032 DOI: 10.1038/Embor.2012.169  0.63
2012 Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes & Development. 26: 2271-85. PMID 23070813 DOI: 10.1101/Gad.196451.112  0.61
2012 Paik DY, Janzen DM, Schafenacker AM, Velasco VS, Shung MS, Cheng D, Huang J, Witte ON, Memarzadeh S. Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation. Stem Cells (Dayton, Ohio). 30: 2487-97. PMID 22911892 DOI: 10.1002/Stem.1207  0.687
2012 Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. Plos One. 7: e42564. PMID 22880034 DOI: 10.1371/Journal.Pone.0042564  0.762
2012 Cai H, Memarzadeh S, Stoyanova T, Beharry Z, Kraft AS, Witte ON. Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer Research. 72: 4672-81. PMID 22805308 DOI: 10.1158/0008-5472.Can-12-0228  0.706
2012 Drake JM, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Komisopoulou E, Huang J, Graeber TG, Witte ON. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 109: 1643-8. PMID 22307624 DOI: 10.1073/Pnas.1120985109  0.61
2012 Drake JM, Huang J, Graeber TG, Witte ON, Graham NA, Stoyanova T, Sedghi A, Goldstein AS, Cai H, Smith DA, Zhang H, Evangelia K. Abstract PR5: Therapeutic targeting of oncogene-specific tyrosine kinase networks during prostate cancer progression Cancer Research. 72: PR5-PR5. DOI: 10.1158/1538-7445.PRCA2012-PR5  0.554
2012 Witte ON. Abstract IA17: Stem cells and prostate cancer Cancer Research. 72: IA17-IA17. DOI: 10.1158/1538-7445.Prca2012-Ia17  0.434
2012 Stoyanova T, Goldstein A, Cai H, Drake JM, Huang J, Zhang H, Witte ON. Abstract C70: Trop2 regulates prostate tumorigenesis and stem cell self-renewal Cancer Research. 72: C70-C70. DOI: 10.1158/1538-7445.PRCA2012-C70  0.56
2012 Zong Y, Huang J, Witte ON. Abstract B67: The epigenetic regulator Hmga2 is sufficient to initiate prostate cancer via paracrine Wnt signaling Cancer Research. 72: B67-B67. DOI: 10.1158/1538-7445.Prca2012-B67  0.458
2012 Smith DA, Zong Y, Kiba A, Witte ON. Abstract B57: Oncostatin M promotes progression of Pten-deficient prostate cancer Cancer Research. 72: B57-B57. DOI: 10.1158/1538-7445.Prca2012-B57  0.416
2012 Ma C, Cheung A, Comin-Anduix B, Chodon T, Koya R, Wu Z, Witte O, Baltimore D, Chmielowski B, Economou J, Ribas A, Heath J. Abstract 4839: Adoptive cell transfer of transgenic T cells elicited a two-wave antitumor cellular immune response consisted of engineered and endogenous T lymphocytes with different sets of functions Cancer Research. 72: 4839-4839. DOI: 10.1158/1538-7445.Am2012-4839  0.367
2012 Goldstein AS, Witte ON. Isolation and characterization of prostate stem cells Stem Cells and Prostate Cancer. 21-36. DOI: 10.1007/978-1-4614-6498-3_2  0.597
2011 Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang LV. Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. Plos One. 6: e27586. PMID 22110680 DOI: 10.1371/Journal.Pone.0027586  0.307
2011 Goldstein AS, Drake JM, Burnes DL, Finley DS, Zhang H, Reiter RE, Huang J, Witte ON. Purification and direct transformation of epithelial progenitor cells from primary human prostate. Nature Protocols. 6: 656-67. PMID 21527922 DOI: 10.1038/Nprot.2011.317  0.643
2011 Memarzadeh S, Cai H, Janzen DM, Xin L, Lukacs R, Riedinger M, Zong Y, DeGendt K, Verhoeven G, Huang J, Witte ON. Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proceedings of the National Academy of Sciences of the United States of America. 108: 7962-7. PMID 21518863 DOI: 10.1073/Pnas.1105243108  0.804
2011 Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 108: 6579-84. PMID 21464326 DOI: 10.1073/Pnas.1103904108  0.703
2011 Goldstein AS, Zong Y, Witte ON. A two-step toward personalized therapies for prostate cancer. Science Translational Medicine. 3: 72ps7. PMID 21368221 DOI: 10.1126/Scitranslmed.3002169  0.6
2011 Tsutsui H, Valamehr B, Hindoyan A, Qiao R, Ding X, Guo S, Witte ON, Liu X, Ho CM, Wu H. An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nature Communications. 2: 167. PMID 21266967 DOI: 10.1038/Ncomms1165  0.37
2011 Cai H, Babic I, Wei X, Huang J, Witte ON. Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer Research. 71: 862-72. PMID 21135112 DOI: 10.1158/0008-5472.Can-10-1605  0.426
2011 Schwarzenberg J, Radu CG, Benz M, Fueger B, Tran AQ, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Schiepers C. Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway. European Journal of Nuclear Medicine and Molecular Imaging. 38: 711-21. PMID 21127859 DOI: 10.1007/S00259-010-1666-Z  0.309
2011 Thai M, Ting PY, McLaughlin J, Cheng D, Müschen M, Witte ON, Colicelli J. ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1. Leukemia. 25: 290-300. PMID 21102429 DOI: 10.1038/Leu.2010.268  0.365
2011 Ribas A, Chodon T, Comin-Anduix B, Sondergaard J, Mok S, Ng C, Escuin-Ordinas H, Atefi M, Chmielowski B, Czernin J, Witte ON, Radu CG, Koya RC. Abstract SY03-04: Novel imaging approaches for immunotherapy and targeted therapy of melanoma in animal models and humans Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy03-04  0.403
2010 Lukacs RU, Memarzadeh S, Wu H, Witte ON. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell. 7: 682-93. PMID 21112563 DOI: 10.1016/J.Stem.2010.11.013  0.812
2010 Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proceedings of the National Academy of Sciences of the United States of America. 107: 17298-303. PMID 20855612 DOI: 10.1073/Pnas.1012548107  0.743
2010 Goldstein AS, Stoyanova T, Witte ON. Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Molecular Oncology. 4: 385-96. PMID 20688584 DOI: 10.1016/J.Molonc.2010.06.009  0.649
2010 Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON. Identification of a cell of origin for human prostate cancer. Science (New York, N.Y.). 329: 568-71. PMID 20671189 DOI: 10.1126/Science.1189992  0.648
2010 Koya RC, Mok S, Comin-Anduix B, Chodon T, Radu CG, Nishimura MI, Witte ON, Ribas A. Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses. Proceedings of the National Academy of Sciences of the United States of America. 107: 14286-91. PMID 20624956 DOI: 10.1073/Pnas.1008300107  0.374
2010 Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 116: 2522-30. PMID 20562326 DOI: 10.1182/Blood-2010-01-264093  0.328
2010 Shu CJ, Campbell DO, Lee JT, Tran AQ, Wengrod JC, Witte ON, Phelps ME, Satyamurthy N, Czernin J, Radu CG. Novel PET probes specific for deoxycytidine kinase. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 51: 1092-8. PMID 20554721 DOI: 10.2967/Jnumed.109.073361  0.702
2010 Nair-Gill E, Wiltzius SM, Wei XX, Cheng D, Riedinger M, Radu CG, Witte ON. PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice. The Journal of Clinical Investigation. 120: 2005-15. PMID 20484820 DOI: 10.1172/Jci41250  0.752
2010 Kamei K, Ohashi M, Gschweng E, Ho Q, Suh J, Tang J, For Yu ZT, Clark AT, Pyle AD, Teitell MA, Lee KB, Witte ON, Tseng HR. Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab On a Chip. 10: 1113-9. PMID 20390128 DOI: 10.1039/B922884E  0.32
2010 Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. Isolation, cultivation and characterization of adult murine prostate stem cells. Nature Protocols. 5: 702-13. PMID 20360765 DOI: 10.1038/Nprot.2010.11  0.814
2010 Mikkola HK, Radu CG, Witte ON. Targeting leukemia stem cells. Nature Biotechnology. 28: 237-8. PMID 20212485 DOI: 10.1038/Nbt0310-237  0.341
2010 Lawson DA, Zong Y, Memarzadeh S, Xin L, Huang J, Witte ON. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proceedings of the National Academy of Sciences of the United States of America. 107: 2610-5. PMID 20133806 DOI: 10.1073/Pnas.0913873107  0.81
2010 Toy G, Austin WR, Liao HI, Cheng D, Singh A, Campbell DO, Ishikawa TO, Lehmann LW, Satyamurthy N, Phelps ME, Herschman HR, Czernin J, Witte ON, Radu CG. Requirement for deoxycytidine kinase in T and B lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. 107: 5551-6. PMID 20080663 DOI: 10.1073/Pnas.0913900107  0.369
2010 Brewer S, Nair-Gill E, Wei B, Chen L, Li X, Riedinger M, Campbell DO, Wiltzius S, Satyamurthy N, Phelps ME, Radu C, Witte ON, Braun J. Epithelial uptake of [18F]1-(2'-deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice. Gastroenterology. 138: 1266-75. PMID 20080095 DOI: 10.1053/J.Gastro.2010.01.003  0.756
2010 Huang J, Witte ON. A seminal finding for prostate cancer? The New England Journal of Medicine. 362: 175-6. PMID 20071710 DOI: 10.1056/Nejmcibr0909965  0.393
2010 Baltimore D, Witte ON, Yang L, Economou J, Ribas A. Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma. Pigment Cell & Melanoma Research. 23: 288-9. PMID 20067554 DOI: 10.1111/J.1755-148X.2010.00666.X  0.51
2010 Garraway IP, Sun W, Tran CP, Perner S, Zhang B, Goldstein AS, Hahm SA, Haider M, Head CS, Reiter RE, Rubin MA, Witte ON. Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. The Prostate. 70: 491-501. PMID 19938015 DOI: 10.1002/Pros.21083  0.66
2010 Laing RE, Nair-Gill E, Witte ON, Radu CG. Visualizing cancer and immune cell function with metabolic positron emission tomography. Current Opinion in Genetics & Development. 20: 100-5. PMID 19931447 DOI: 10.1016/J.Gde.2009.10.008  0.762
2010 Nair-Gill ED, Shu CJ, Hildebrandt IJ, Campbell DO, Witte ON, Radu CG. Imaging cell trafficking and immune cell activation using PET reporter genes Molecular Imaging With Reporter Genes. 258-274. DOI: 10.1017/CBO9780511730405.012  0.796
2009 Mulholland DJ, Xin L, Morim A, Lawson D, Witte O, Wu H. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Research. 69: 8555-62. PMID 19887604 DOI: 10.1158/0008-5472.Can-08-4673  0.698
2009 Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 12465-70. PMID 19592505 DOI: 10.1073/Pnas.0905931106  0.763
2009 Kwong GA, Radu CG, Hwang K, Shu CJ, Ma C, Koya RC, Comin-Anduix B, Hadrup SR, Bailey RC, Witte ON, Schumacher TN, Ribas A, Heath JR. Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells. Journal of the American Chemical Society. 131: 9695-703. PMID 19552409 DOI: 10.1021/Ja9006707  0.728
2009 Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Phelps ME, Czernin J, Witte ON, Radu CG. Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 106: 2847-52. PMID 19196993 DOI: 10.1073/Pnas.0812890106  0.339
2009 Yu ZT, Kamei K, Takahashi H, Shu CJ, Wang X, He GW, Silverman R, Radu CG, Witte ON, Lee KB, Tseng HR. Integrated microfluidic devices for combinatorial cell-based assays. Biomedical Microdevices. 11: 547-55. PMID 19130244 DOI: 10.1007/S10544-008-9260-X  0.736
2009 Shu CJ, Radu CG, Shelly SM, Vo DD, Prins R, Ribas A, Phelps ME, Witte ON. Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen. International Immunology. 21: 155-65. PMID 19106231 DOI: 10.1093/Intimm/Dxn133  0.737
2009 Sun W, Mayle A, Zhang B, Goldstein AS, Chen D, Wu H, Witte ON, Garraway IP. A DISCREET EPITHELIAL POPULATION DERIVED FROM HUMAN PROSTATE TISSUE DEMONSTRATES STEM/PROGENITOR CELL ACTIVITY Journal of Urology. 181: 43-43. DOI: 10.1016/S0022-5347(09)60133-6  0.598
2008 Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proceedings of the National Academy of Sciences of the United States of America. 105: 20882-7. PMID 19088204 DOI: 10.1073/Pnas.0811411106  0.779
2008 Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. Epithelial stem cells of the prostate and their role in cancer progression. Cold Spring Harbor Symposia On Quantitative Biology. 73: 491-502. PMID 19022743 DOI: 10.1101/Sqb.2008.73.012  0.814
2008 Valamehr B, Jonas SJ, Polleux J, Qiao R, Guo S, Gschweng EH, Stiles B, Kam K, Luo TJ, Witte ON, Liu X, Dunn B, Wu H. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proceedings of the National Academy of Sciences of the United States of America. 105: 14459-64. PMID 18791068 DOI: 10.1073/Pnas.0807235105  0.346
2008 Radu CG, Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON. Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog. Nature Medicine. 14: 783-8. PMID 18542051 DOI: 10.1038/Nm1724  0.776
2008 Nair-Gill ED, Shu CJ, Radu CG, Witte ON. Non-invasive imaging of adaptive immunity using positron emission tomography. Immunological Reviews. 221: 214-28. PMID 18275485 DOI: 10.1111/J.1600-065X.2008.00585.X  0.775
2008 Prins RM, Shu CJ, Radu CG, Vo DD, Khan-Farooqi H, Soto H, Yang MY, Lin MS, Shelly S, Witte ON, Ribas A, Liau LM. Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain. Cancer Immunology, Immunotherapy : Cii. 57: 1279-89. PMID 18253732 DOI: 10.1007/S00262-008-0461-1  0.719
2008 Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. The Journal of Biological Chemistry. 283: 5296-305. PMID 18089568 DOI: 10.1074/Jbc.M706586200  0.337
2008 Moore ML, Teitell MA, Kim Y, Watabe T, Reiter RE, Witte ON, Dubey P. Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation. The Prostate. 68: 139-51. PMID 18044730 DOI: 10.1002/Pros.20686  0.421
2007 McLaughlin J, Cheng D, Singer O, Lukacs RU, Radu CG, Verma IM, Witte ON. Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proceedings of the National Academy of Sciences of the United States of America. 104: 20501-6. PMID 18079287 DOI: 10.1073/Pnas.0710532105  0.795
2007 Memarzadeh S, Xin L, Mulholland DJ, Mansukhani A, Wu H, Teitell MA, Witte ON. Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell. 12: 572-85. PMID 18068633 DOI: 10.1016/J.Ccr.2007.11.002  0.698
2007 Lawson DA, Witte ON. Stem cells in prostate cancer initiation and progression. The Journal of Clinical Investigation. 117: 2044-50. PMID 17671638 DOI: 10.1172/Jci32810  0.702
2007 Xin L, Lukacs RU, Lawson DA, Cheng D, Witte ON. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells (Dayton, Ohio). 25: 2760-9. PMID 17641240 DOI: 10.1634/Stemcells.2007-0355  0.819
2007 Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 110: 1831-9. PMID 17554060 DOI: 10.1182/Blood-2007-01-069401  0.329
2007 Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 104: 1937-42. PMID 17261805 DOI: 10.1073/Pnas.0610544104  0.698
2007 Bailey RC, Kwong GA, Radu CG, Witte ON, Heath JR. DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins. Journal of the American Chemical Society. 129: 1959-67. PMID 17260987 DOI: 10.1021/Ja065930I  0.315
2007 Lawson DA, Xin L, Lukacs RU, Cheng D, Witte ON. Isolation and functional characterization of murine prostate stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 181-6. PMID 17185413 DOI: 10.1073/Pnas.0609684104  0.817
2007 Garraway I, Tran C, Cai Y, Hahm S, Reiter R, Witte O. 530: Defining Human Prostate Stem Cells Via Development and Characterization of Prostaspheres Journal of Urology. 177: 176-176. DOI: 10.1016/S0022-5347(18)30770-5  0.422
2006 Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 9: 367-78. PMID 16697957 DOI: 10.1016/J.Ccr.2006.03.031  0.448
2006 Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proceedings of the National Academy of Sciences of the United States of America. 103: 7789-94. PMID 16682621 DOI: 10.1073/Pnas.0602567103  0.684
2006 Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proceedings of the National Academy of Sciences of the United States of America. 103: 1480-5. PMID 16432235 DOI: 10.1073/Pnas.0510652103  0.722
2006 Khan AQ, Sen G, Guo S, Witte ON, Snapper CM. Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses. Infection and Immunity. 74: 1419-24. PMID 16428797 DOI: 10.1128/Iai.74.2.1419-1424.2006  0.316
2006 Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON. Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Molecular and Cellular Biology. 26: 668-77. PMID 16382156 DOI: 10.1128/Mcb.26.2.668-677.2006  0.353
2006 Guo S, Wahl MI, Witte ON. Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families. International Immunology. 18: 79-87. PMID 16291652 DOI: 10.1093/Intimm/Dxh351  0.307
2005 Lawson DA, Xin L, Lukacs R, Xu Q, Cheng D, Witte ON. Prostate stem cells and prostate cancer. Cold Spring Harbor Symposia On Quantitative Biology. 70: 187-96. PMID 16869753 DOI: 10.1101/Sqb.2005.70.003  0.823
2005 Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, et al. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science (New York, N.Y.). 310: 1793-6. PMID 16357255 DOI: 10.1126/Science.1118919  0.685
2005 Shu CJ, Guo S, Kim YJ, Shelly SM, Nijagal A, Ray P, Gambhir SS, Radu CG, Witte ON. Visualization of a primary anti-tumor immune response by positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 102: 17412-7. PMID 16293690 DOI: 10.1073/Pnas.0508698102  0.732
2005 Xin L, Lawson DA, Witte ON. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 6942-7. PMID 15860580 DOI: 10.1073/Pnas.0502320102  0.718
2005 Wang L, Radu CG, Yang LV, Bentolila LA, Riedinger M, Witte ON. Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A. Molecular Biology of the Cell. 16: 2234-47. PMID 15728718 DOI: 10.1091/Mbc.E04-12-1044  0.305
2005 Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 1632-7. PMID 15665078 DOI: 10.1073/Pnas.0409415102  0.306
2005 Witte ON, Kabarowski JH, Xu Y, Le LQ, Zhu K. Retraction. Science (New York, N.Y.). 307: 206. PMID 15653487 DOI: 10.1126/science.307.5707.206b  0.511
2004 Wong S, McLaughlin J, Cheng D, Zhang C, Shokat KM, Witte ON. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proceedings of the National Academy of Sciences of the United States of America. 101: 17456-61. PMID 15505216 DOI: 10.1073/Pnas.0407061101  0.631
2004 Kim YJ, Dubey P, Ray P, Gambhir SS, Witte ON. Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 6: 331-40. PMID 15380743 DOI: 10.1016/J.Mibio.2004.06.009  0.329
2004 Guo S, Ferl GZ, Deora R, Riedinger M, Yin S, Kerwin JL, Loo JA, Witte ON. A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 14180-5. PMID 15375214 DOI: 10.1073/Pnas.0405878101  0.737
2004 Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood. 104: 1281-90. PMID 15142874 DOI: 10.1182/Blood-2003-09-3044  0.588
2004 Dorshkind K, Witte O. Got MLL? Definitive hematopoiesis requires MLL gene expression Molecular Cell. 13: 765-766. PMID 15053868 DOI: 10.1016/S1097-2765(04)00159-5  0.355
2004 Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annual Review of Immunology. 22: 247-306. PMID 15032571 DOI: 10.1146/Annurev.Immunol.22.012703.104753  0.584
2004 Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON, Fruman DA. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood. 103: 4268-75. PMID 14976048 DOI: 10.1182/Blood-2003-07-2193  0.626
2003 Wong S, McLaughlin J, Cheng D, Shannon K, Robb L, Witte ON. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 11630-5. PMID 14500898 DOI: 10.1073/Pnas.2035020100  0.555
2003 Ferl GZ, Timmerman JM, Witte ON. Extending the utility of gene profiling data by bridging microarray platforms. Proceedings of the National Academy of Sciences of the United States of America. 100: 10585-7. PMID 12963810 DOI: 10.1073/Pnas.2034937100  0.692
2003 Xin L, Ide H, Kim Y, Dubey P, Witte ON. In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme. Proceedings of the National Academy of Sciences of the United States of America. 100: 11896-903. PMID 12909713 DOI: 10.1073/Pnas.1734139100  0.444
2003 Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB. Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. Journal of Immunology (Baltimore, Md. : 1950). 171: 1850-8. PMID 12902486 DOI: 10.4049/Jimmunol.171.4.1850  0.345
2003 Whyburn LR, Halcomb KE, Contreras CM, Pappu R, Witte ON, Chan AC, Satterthwaite AB. Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase. International Immunology. 15: 383-92. PMID 12618482 DOI: 10.1093/Intimm/Dxg034  0.378
2003 Dubey P, Su H, Adonai N, Du S, Rosato A, Braun J, Gambhir SS, Witte ON. Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 100: 1232-7. PMID 12547911 DOI: 10.1073/Pnas.0337418100  0.361
2003 Wong S, McLaughlin J, Cheng D, Witte ON. Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood. 101: 4088-97. PMID 12521991 DOI: 10.1182/Blood-2002-11-3376  0.641
2002 Ide H, Seligson DB, Memarzadeh S, Xin L, Horvath S, Dubey P, Flick MB, Kacinski BM, Palotie A, Witte ON. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 99: 14404-9. PMID 12381783 DOI: 10.1073/Pnas.222537099  0.693
2002 Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer Cell. 1: 381-91. PMID 12086852 DOI: 10.1016/S1535-6108(02)00058-2  0.725
2002 Era T, Wong S, Witte ON. Analysis of Bcr-Abl function using an in vitro embryonic stem cell differentiation system. Methods in Molecular Biology (Clifton, N.J.). 185: 83-95. PMID 11769015 DOI: 10.1385/1-59259-241-4:83  0.602
2002 Fruman DA, Ferl GZ, An SS, Donahue AC, Satterthwaite AB, Witte ON. Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 359-64. PMID 11756681 DOI: 10.1073/Pnas.012605099  0.729
2002 Watabe T, Lin M, Ide H, Donjacour AA, Cunha GR, Witte ON, Reiter RE. Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. Proceedings of the National Academy of Sciences of the United States of America. 99: 401-6. PMID 11752398 DOI: 10.1073/Pnas.012574899  0.456
2001 Wong S, Witte ON. Modeling Philadelphia chromosome positive leukemias. Oncogene. 20: 5644-59. PMID 11607816 DOI: 10.1038/Sj.Onc.1204638  0.582
2001 Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, Kato RM, Tabuchi R, Tarakhovsky A, Kawakami T, Turck CW, Witte ON, Rawlings DJ. PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. The Embo Journal. 20: 5692-702. PMID 11598012 DOI: 10.1093/Emboj/20.20.5692  0.362
2001 Witte O. The role of Bcr-Abl in chronic myeloid leukemia and stem cell biology Seminars in Hematology. 38: 3-8. PMID 11526595 DOI: 10.1016/S0037-1963(01)90111-8  0.418
2001 Kabarowski JH, Zhu K, Le LQ, Witte ON, Xu Y. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science (New York, N.Y.). 293: 702-5. PMID 11474113 DOI: 10.1126/Science.1061781  0.585
2001 Tomlinson MG, Woods DB, McMahon M, Wahl MI, Witte ON, Kurosaki T, Bolen JB, Johnston JA. A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. Bmc Immunology. 2: 4. PMID 11410123 DOI: 10.1186/1471-2172-2-4  0.363
2001 Le LQ, Kabarowski JH, Weng Z, Satterthwaite AB, Harvill ET, Jensen ER, Miller JF, Witte ON. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity. 14: 561-71. PMID 11371358 DOI: 10.1016/S1074-7613(01)00145-5  0.619
2001 Dubey P, Wu H, Reiter RE, Witte ON. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression Cancer Research. 61: 3256-3261. PMID 11309275  0.339
2001 Kouro T, Nagata K, Takaki S, Nisitani S, Hirano M, Wahl MI, Witte ON, Karasuyama H, Takatsu K. Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. International Immunology. 13: 485-93. PMID 11282988 DOI: 10.1093/Intimm/13.4.485  0.339
2001 Saffran DC, Raitano AB, Hubert RS, Witte ON, Reiter RE, Jakobovits A. Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts Proceedings of the National Academy of Sciences of the United States of America. 98: 2658-2663. PMID 11226295 DOI: 10.1073/Pnas.051624698  0.431
2000 Kabarowski JHS, Witte ON. Consequences of BCR-ABL expression within the hematopoietic stem cell in chronic myeloid leukemia Stem Cells. 18: 399-408. PMID 11072027 DOI: 10.1002/Stem.180399  0.372
2000 Kabarowski JH, Feramisco JD, Le LQ, Gu JL, Luoh SW, Simon MI, Witte ON. Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement. Proceedings of the National Academy of Sciences of the United States of America. 97: 12109-14. PMID 11050239 DOI: 10.1073/Pnas.97.22.12109  0.607
2000 Lim YM, Wong S, Lau G, Witte ON, Colicelli J. BCR/ABL inhibition by an escort/phosphatase fusion protein. Proceedings of the National Academy of Sciences of the United States of America. 97: 12233-8. PMID 11027300 DOI: 10.1073/Pnas.210253497  0.63
2000 Satterthwaite AB, Witte ON. The role of Bruton's tyrosine kinase in B-cell development and function: A genetic perspective Immunological Reviews. 175: 120-127. PMID 10933597 DOI: 10.1034/J.1600-065X.2000.017504.X  0.373
2000 Fruman DA, Satterthwaite AB, Witte ON. Xid-like phenotypes: A B cell signalosome takes shape Immunity. 13: 1-3. PMID 10933389 DOI: 10.1016/S1074-7613(00)00002-9  0.346
2000 Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. Journal of Immunology (Baltimore, Md. : 1950). 165: 1210-9. PMID 10903718 DOI: 10.4049/Jimmunol.165.3.1210  0.382
2000 Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. 97: 6687-92. PMID 10829070 DOI: 10.1073/Pnas.110146697  0.39
2000 Gu Z, Thomas G, Yamashiro J, Shintaku IP, Dorey F, Raitano A, Witte ON, Said JW, Loda M, Reiter RE. Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer. Oncogene. 19: 1288-96. PMID 10713670 DOI: 10.1038/Sj.Onc.1203426  0.445
2000 Nisitani S, Satterthwaite AB, Akashi K, Weissman IL, Witte ON, Wahl MI. Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 2737-42. PMID 10688914 DOI: 10.1073/Pnas.050583597  0.522
2000 Era T, Witte ON. Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate Proceedings of the National Academy of Sciences of the United States of America. 97: 1737-1742. PMID 10677527 DOI: 10.1073/Pnas.97.4.1737  0.403
2000 Oda A, Ikeda Y, Ochs HD, Druker BJ, Ozaki K, Handa M, Ariga T, Sakiyama Y, Witte ON, Wahl MI. Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking. Blood. 95: 1663-1670. DOI: 10.1182/Blood.V95.5.1663.005K44_1663_1670  0.305
1999 Saffran DC, Reiter RE, Jakobovits A, Witte ON. Target antigens for prostate cancer immunotherapy Cancer and Metastasis Reviews. 18: 437-449. PMID 10855787 DOI: 10.1023/A:1006333222424  0.397
1999 Nisitani S, Kato RM, Rawlings DJ, Witte ON, Wahl MI. In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies Proceedings of the National Academy of Sciences of the United States of America. 96: 2221-2226. PMID 10051622 DOI: 10.1073/Pnas.96.5.2221  0.342
1999 Shi CS, Tuscano JM, Witte ON, Kehrl JH. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway Blood. 93: 1338-1345. PMID 9949177 DOI: 10.1182/Blood.V93.4.1338  0.313
1999 Reiter RE, Yamashiro J, Sawyers C, Loda M, Witte ON. A Type Ii Transmembrane Glycoprotein Associated With Osteogenesis Can Accelerate Androgen-Independent Prostate Cancer Progression In Vivo The Journal of Urology. 128. DOI: 10.1097/00005392-199904010-00516  0.56
1998 Mahlmann S, McLaughlin J, Afar DE, Mohr R, Kay RJ, Witte ON. Dissection of signaling pathways and cloning of new signal transducers in tyrosine kinase-induced pathways by genetic selection. Leukemia. 12: 1858-65. PMID 9844916 DOI: 10.1038/Sj.Leu.2401231  0.337
1998 Satterthwaite AB, Rawlings DJ, Witte ON. DSHP: A 'power bar' for sustained immune responses? Proceedings of the National Academy of Sciences of the United States of America. 95: 13355-13357. PMID 9811804 DOI: 10.1073/Pnas.95.23.13355  0.33
1998 Weng Z, Fluckiger AC, Nisitani S, Wahl MI, Le LQ, Hunter CA, Fernal AA, Le Beau MM, Witte ON. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proceedings of the National Academy of Sciences of the United States of America. 95: 12334-9. PMID 9770487 DOI: 10.1073/Pnas.95.21.12334  0.643
1998 Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. The Journal of Experimental Medicine. 188: 833-44. PMID 9730885 DOI: 10.1084/Jem.188.5.833  0.52
1998 Satterthwaite AB, Li Z, Witte ON. Btk function in B cell development and responsee Seminars in Immunology. 10: 309-316. PMID 9695187 DOI: 10.1006/Smim.1998.0123  0.388
1998 Lieberman JR, Le LQ, Wu L, Finerman GA, Berk A, Witte ON, Stevenson S. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 16: 330-9. PMID 9671928 DOI: 10.1002/Jor.1100160309  0.611
1998 Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, ... Witte ON, et al. Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. The Journal of Experimental Medicine. 187: 1235-47. PMID 9547335 DOI: 10.1084/Jem.187.8.1235  0.539
1998 Amarante-Mendes GP, McGahon AJ, Nishioka WK, Afar DE, Witte ON, Green DR. Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL. Oncogene. 16: 1383-90. PMID 9525737 DOI: 10.1038/Sj.Onc.1201664  0.336
1998 Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 95: 1735-40. PMID 9465086 DOI: 10.1073/Pnas.95.4.1735  0.452
1998 Fluckiger A, Sanz E, Garcia-Lloret M, Su T, Hao Q, Kato R, Quan S, Hera Adl, Witte ON, Rawlings DJ. In Vitro Reconstitution of Human B-Cell Ontogeny: From CD34+ Multipotent Progenitors to Ig-Secreting Cells Blood. 92: 4509-4520. DOI: 10.1182/Blood.V92.12.4509.424K37_4509_4520  0.761
1998 Honda H, Oda H, Suzuki T, Takahashi T, Witte ON, Ozawa K, Ishikawa T, Yazaki Y, Hirai H. Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias Blood. 91: 2067-2075. DOI: 10.1182/Blood.V91.6.2067.2067_2067_2075  0.342
1997 Satterthwaite AB, Cheroutre H, Khan WN, Sideras P, Witte ON. Btk dosage determines sensitivity to B cell antigen receptor cross- linking Proceedings of the National Academy of Sciences of the United States of America. 94: 13152-13157. PMID 9371815 DOI: 10.1073/Pnas.94.24.13152  0.365
1997 Li T, Rawlings DJ, Park H, Kato RM, Witte ON, Satterthwaite AB. Constitutive membrane association potentiates activation of Bruton tyrosine kinase Oncogene. 15: 1375-1383. PMID 9333013 DOI: 10.1038/Sj.Onc.1201308  0.306
1997 Wahl MI, Fluckiger AC, Kato RM, Park H, Witte ON, Rawlings DJ. Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proceedings of the National Academy of Sciences of the United States of America. 94: 11526-33. PMID 9326643 DOI: 10.1073/Pnas.94.21.11526  0.329
1997 Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G. A functional screen for regulators of the c-Abl protein tyrosine kinase Leukemia. 11: 313-315. PMID 9209375 DOI: 10.1038/Sj.Leu.2400616  0.35
1997 Afar DE, Han L, McLaughlin J, Wong S, Dhaka A, Parmar K, Rosenberg N, Witte ON, Colicelli J. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Immunity. 6: 773-82. PMID 9208849 DOI: 10.1016/S1074-7613(00)80452-5  0.611
1997 Klein KA, Reiter RE, Redula J, Moradi H, Zhu XL, Brothman AR, Lamb DJ, Marcelli M, Belldegrun A, Witte ON, Sawyers CL. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nature Medicine. 3: 402-8. PMID 9095173 DOI: 10.1038/Nm0497-402  0.583
1996 Maru Y, Witte ON, Shibuya M. BCR-ABL induces neurite-like structures and BCR lacking the SH2-binding domain induces cell rounding in PC12 cells Experimental Cell Research. 229: 438-445. PMID 8986627 DOI: 10.1006/Excr.1996.0389  0.376
1996 Satterthwaite AB, Witte ON. Lessons from human genetic variants in the study of B-cell differentiation Current Opinion in Immunology. 8: 454-458. PMID 8794006 DOI: 10.1016/S0952-7915(96)80029-X  0.35
1996 Satterthwaite A, Witte O. Genetic analysis of tyrosine kinase function in B cell development Annual Review of Immunology. 14: 131-154. PMID 8717510 DOI: 10.1146/Annurev.Immunol.14.1.131  0.38
1996 Afar DEH, Park H, Howell BW, Rawlings DJ, Cooper J, Witte ON. Regulation of Btk by Src family tyrosine kinases Molecular and Cellular Biology. 16: 3465-3471. PMID 8668162 DOI: 10.1128/Mcb.16.7.3465  0.334
1996 Maru Y, Afar DE, Witte ON, Shibuya M. The dimerization property of glutathione S-transferase partially reactivates Bcr-Abl lacking the oligomerization domain Journal of Biological Chemistry. 271: 15353-15357. PMID 8663064 DOI: 10.1074/Jbc.271.26.15353  0.364
1996 Park H, Wahl MI, Afar DEH, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON. Regulation of Btk function by a major autophosphorylation site within the SH3 domain Immunity. 4: 515-525. PMID 8630736 DOI: 10.1016/S1074-7613(00)80417-3  0.313
1996 Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science (New York, N.Y.). 271: 822-5. PMID 8629002 DOI: 10.1126/Science.271.5250.822  0.329
1996 Maru Y, Witte ON, Shibuya M. Deletion of the ABL SH3 domain reactivates de-oligomerized BCR-ABL for growth factor independence Febs Letters. 379: 244-246. PMID 8603698 DOI: 10.1016/0014-5793(95)01518-3  0.316
1995 Rawlings DJ, Witte ON. The Btk subfamily of cytoplasmic tyrosine kinases: Structure, regulation and function Seminars in Immunology. 7: 237-246. PMID 8520028 DOI: 10.1006/Smim.1995.0028  0.358
1995 Sawyers CL, McLaughlin J, Witte ON. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene Journal of Experimental Medicine. 181: 307-313. PMID 7807010 DOI: 10.1084/Jem.181.1.307  0.5
1995 Afar DEH, Mclaughlin J, Sherr CJ, Witte ON, Roussel MF. Signaling by ABL oncogenes through cyclin D1 Proceedings of the National Academy of Sciences of the United States of America. 92: 9540-9544. PMID 7568169 DOI: 10.1073/Pnas.92.21.9540  0.342
1995 Goga A, McLaughlin J, Afar DEH, Saffran DC, Witte ON. Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene Cell. 82: 981-988. PMID 7553858 DOI: 10.1016/0092-8674(95)90277-5  0.34
1995 Li T, Tsukada S, Satterthwaite A, Havlik MH, Park H, Takatsu K, Witte ON. Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity. 2: 451-60. PMID 7538439 DOI: 10.1016/1074-7613(95)90026-8  0.328
1995 Rawlings DJ, Quan SG, Kato RM, Witte ON. Long-term culture system for selective growth of human B-cell progenitors Proceedings of the National Academy of Sciences of the United States of America. 92: 1570-1574. PMID 7533295 DOI: 10.1073/Pnas.92.5.1570  0.349
1995 Afar DEH, Witte ON. Characterization of breakpoint cluster region kinase and SH2-binding activities Methods in Enzymology. 256: 125-129. PMID 7476425 DOI: 10.1016/0076-6879(95)56017-3  0.305
1995 Honda H, Fujii T, Takatoku M, Mano H, Witte O, Yazaki Y, Hirai H. Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice Blood. 85: 2853-2861. DOI: 10.1182/Blood.V85.10.2853.Bloodjournal85102853  0.373
1994 Saffran DC, Parolini O, Fitch-Hilgenberg ME, Rawlings DJ, Afar DE, Witte ON, Conley ME. Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia. The New England Journal of Medicine. 330: 1488-91. PMID 8164701 DOI: 10.1056/Nejm199405263302104  0.3
1994 Afar DEH, Goga A, McLaughlin J, Witte ON, Sawyers CL. Differential complementation of Bcr-Abl point mutants with c-Myc Science. 264: 424-426. PMID 8153630 DOI: 10.1126/Science.8153630  0.519
1994 Rawlings DJ, Witte ON. Bruton's tyrosine kinase is a key regulator in B-cell development Immunological Reviews. 105-119. PMID 8070812 DOI: 10.1111/J.1600-065X.1994.Tb00849.X  0.336
1994 Orr SL, Hughes TP, Sawyers CL, Kato RM, Quan SG, Williams SP, Witte ON, Hood L. Isolation of unknown genes from human bone marrow by differential screening and single-pass cDNA sequence determination. Proceedings of the National Academy of Sciences of the United States of America. 91: 11869-73. PMID 7991548 DOI: 10.1073/Pnas.91.25.11869  0.502
1994 Tsukada S, Rawlings DJ, Witte ON. Role of Bruton's tyrosine kinase in immunodeficiency Current Opinion in Immunology. 6: 623-630. PMID 7946052 DOI: 10.1016/0952-7915(94)90151-1  0.312
1994 Faust EA, Rawlings DJ, Saffran DC, Witte ON. Development of btk transgenic mice Current Topics in Microbiology and Immunology. 194: 363-370. PMID 7895510 DOI: 10.1007/978-3-642-79275-5_42  0.391
1994 Afar DE, Goga A, Cohen L, Sawyers CL, McLaughlin J, Mohr RN, Witte ON. Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL. Cold Spring Harbor Symposia On Quantitative Biology. 59: 589-94. PMID 7587117 DOI: 10.1101/Sqb.1994.059.01.067  0.328
1994 Saouaf SJ, Mahajan S, Rowley RB, Kut SA, Fargnoli J, Burkhardt AL, Tsukada S, Witte ON, Bolen JB. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proceedings of the National Academy of Sciences of the United States of America. 91: 9524-8. PMID 7524079 DOI: 10.1073/Pnas.91.20.9524  0.345
1994 Sawyers CL, McLaughlin J, Goga A, Havlik M, Witte O. The nuclear tyrosine kinase c-Abl negatively regulates cell growth Cell. 77: 121-131. PMID 7512450 DOI: 10.1016/0092-8674(94)90240-2  0.546
1993 Gishizky ML, Johnson-White J, Witte ON. Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia- like syndrome in mice Proceedings of the National Academy of Sciences of the United States of America. 90: 3755-3759. PMID 8475126 DOI: 10.1073/Pnas.90.8.3755  0.313
1993 Pendergast AM, Gishizky ML, Havlik MH, Witte ON. SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. Molecular and Cellular Biology. 13: 1728-36. PMID 8441409 DOI: 10.1128/Mcb.13.3.1728  0.626
1993 Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia Cell. 72: 279-290. PMID 8425221 DOI: 10.1016/0092-8674(93)90667-F  0.373
1993 Goga A, McLaughlin J, Pendergast AM, Parmar K, Muller A, Rosenberg N, Witte ON. Oncogenic activation of c-ABL by mutation within its last exon. Molecular and Cellular Biology. 13: 4967-75. PMID 8336729 DOI: 10.1128/Mcb.13.8.4967  0.625
1993 Muller AJ, Pendergast AM, Parmar K, Havlik MH, Rosenberg N, Witte ON. En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. 90: 3457-61. PMID 7682703 DOI: 10.1073/Pnas.90.8.3457  0.595
1993 Faust EA, Saffran DC, Toksoz D, Williams DA, Witte ON. Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells Journal of Experimental Medicine. 177: 915-923. PMID 7681470 DOI: 10.1084/Jem.177.4.915  0.355
1992 Sawyers CL, Gishizky ML, Quan S, Golde DW, Witte ON. Propagation of human elastic myeloid leukemias in the SCID mouse Blood. 79: 2089-2098. PMID 1562735 DOI: 10.1182/Blood.V79.8.2089.Bloodjournal7982089  0.518
1992 Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes Cell. 70: 901-910. PMID 1525828 DOI: 10.1016/0092-8674(92)90241-4  0.521
1992 Gishizky ML, Witte ON. BCR/ABL enhances growth of multipotent progenitor cells but does not block their differentiation potential in vitro Current Topics in Microbiology and Immunology. 182: 65-72. PMID 1490392 DOI: 10.1007/978-3-642-77633-5_8  0.392
1992 Saffran DC, Faust EA, Witte ON. Establishment of a reproductive culture technique for the selective growth of B-cell progenitors Current Topics in Microbiology and Immunology. 182: 37-43. PMID 1490376 DOI: 10.1007/978-3-642-77633-5_5  0.384
1992 Muller AJ, Pendergast AM, Havlik MH, Puil L, Pawson T, Witte ON. A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. Molecular and Cellular Biology. 12: 5087-93. PMID 1383690 DOI: 10.1128/Mcb.12.11.5087  0.581
1992 Gishizky ML, Witte ON. Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro Science. 256: 836-839. PMID 1375394 DOI: 10.1126/Science.1375394  0.339
1991 Muller AJ, Young JC, Pendergast AM, Pondel M, Landau NR, Littman DR, Witte ON. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Molecular and Cellular Biology. 11: 1785-92. PMID 2005881 DOI: 10.1128/Mcb.11.4.1785  0.616
1991 Saxon A, Macy E, Denis K, Tary-Lehmann M, Witte O, Braun J. Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. Journal of Clinical Investigation. 87: 658-665. PMID 1991850 DOI: 10.1172/Jci115043  0.353
1991 Sawyers CL, Denny CT, Witte ON. Leukemia and the disruption of normal hematopoiesis Cell. 64: 337-350. PMID 1988151 DOI: 10.1016/0092-8674(91)90643-D  0.555
1991 Gishizky ML, McLaughlin J, Pendergast AM, Witte ON. The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells. Oncogene. 6: 1299-306. PMID 1886706  0.556
1991 Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell. 66: 161-71. PMID 1712671 DOI: 10.1016/0092-8674(91)90148-R  0.604
1991 Pendergast AM, Muller AJ, Havlik MH, Clark R, McCormick F, Witte ON. Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 88: 5927-31. PMID 1712111 DOI: 10.1073/Pnas.88.13.5927  0.617
1991 Maru Y, Witte ON. The BCR gene encodes a novel serine/threonine kinase activity within a single exon Cell. 67: 459-468. PMID 1657398 DOI: 10.1016/0092-8674(91)90521-Y  0.315
1990 Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science (New York, N.Y.). 247: 1079-82. PMID 2408149 DOI: 10.1126/Science.2408149  0.618
1990 Scherle PA, Dorshkind K, Witte ON. Clonal lymphoid progenitor cell lines expressing the BCR/ABL oncogene retain full differentiative function Proceedings of the National Academy of Sciences of the United States of America. 87: 1908-1912. PMID 2408044 DOI: 10.1073/Pnas.87.5.1908  0.417
1990 Sawyers CL, Timson L, Kawasaki ES, Clark SS, Witte ON, Champlin R. Molecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America. 87: 563-7. PMID 2405384 DOI: 10.1073/Pnas.87.2.563  0.468
1990 Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL Proceedings of the National Academy of Sciences of the United States of America. 87: 6649-6653. PMID 2204061 DOI: 10.1073/Pnas.87.17.6649  0.381
1990 Scherle PA, Witte ON. Functionality of clonal lymphoid progenitor cells expressing the P210 BCR/ABL oncogene Current Topics in Microbiology and Immunology. 166: 189-195. PMID 2073798 DOI: 10.1007/978-3-642-75889-8_24  0.416
1990 Denis KA, Witte ON, Brinster RL, Provost S, Storb U. Delay of Early B-Lymphocyte Development By Gamma 2b Immunoglobulin Transgene: Effect on Differentiation- Specific Molecules Developmental Immunology. 1: 105-112. PMID 1967016 DOI: 10.1155/1990/71584  0.328
1989 McLaughlin J, Chianese E, Witte ON. Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells Molecular and Cellular Biology. 9: 1866-1874. PMID 2747638 DOI: 10.1128/Mcb.9.5.1866  0.312
1989 Gross Lugo T, Witte ON. The BCR-ABL oncogene transforms rat-1 cells and cooperates with v-myc Molecular and Cellular Biology. 9: 1263-1270. PMID 2725497 DOI: 10.1128/Mcb.9.3.1263  0.373
1989 Ponzetto C, Wadewitz AG, Pendergast AM, Witte ON, Wolgemuth DJ. P150c-abl is detected in mouse male germ cells by an in vitro kinase assay and is associated with stage-specific phosphoproteins in haploid cells. Oncogene. 4: 685-90. PMID 2660070  0.611
1989 Muller AJ, Witte ON. The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation Molecular and Cellular Biology. 9: 5234-5238. PMID 2601719 DOI: 10.1128/Mcb.9.11.5234  0.322
1989 Pendergast AM, Clark R, Kawasaki ES, McCormick FP, Witte ON. Baculovirus expression of functional P210 BCR-ABL oncogene product. Oncogene. 4: 759-66. PMID 2499863  0.583
1988 Clark SS, McLaughlin J, Timmons M, Pendergast AM, Ben-Neriah Y, Dow LW, Crist W, Rovera G, Smith SD, Witte ON. Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL). Science (New York, N.Y.). 239: 775-7. PMID 3422516 DOI: 10.1126/Science.3422516  0.562
1988 Young JC, Witte ON. Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures. Molecular and Cellular Biology. 8: 4079-87. PMID 3263566 DOI: 10.1128/Mcb.8.10.4079  0.363
1988 Witte ON. Closely related BCR/ABL oncogenes are associated with the distinctive clinical biologies of Philadelphia chromosome positive chronic myelogenous and acute lymphocytic leukemia Current Topics in Microbiology and Immunology. 141: 42-49. PMID 3063449 DOI: 10.1007/978-3-642-74006-0_7  0.307
1988 Schwartz RC, Witte ON. A recombinant murine retrovirus expressing v-rel is cytopathic Virology. 165: 182-190. PMID 2838956 DOI: 10.1016/0042-6822(88)90671-X  0.353
1987 Clark SS, Mclaughlin J, Crist WM, Champlin R, Witte ON. Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL Science. 235: 85-88. PMID 3541203 DOI: 10.1126/Science.3541203  0.309
1987 Mes-Masson AM, McLaughlin J, Daley GQ, Paskind M, Witte ON. Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome. Proceedings of the National Academy of Sciences of the United States of America. 83: 9768-72. PMID 3540951 DOI: 10.1073/Pnas.83.24.9768  0.473
1987 McLaughlin J, Chianese E, Witte ON. In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome Proceedings of the National Academy of Sciences of the United States of America. 84: 6558-6562. PMID 3498165 DOI: 10.1073/Pnas.84.18.6558  0.373
1987 Denis KA, Dorshkind K, Witte ON. Regulated progression of B lymphocyte differentiation from cultured fetal liver Journal of Experimental Medicine. 166: 391-403. PMID 3496415 DOI: 10.1084/Jem.166.2.391  0.305
1987 Pendergast AM, Witte ON. Role of the ABL oncogene tyrosine kinase activity in human leukaemia. BaillièRe's Clinical Haematology. 1: 1001-20. PMID 3332851 DOI: 10.1016/S0950-3536(87)80036-7  0.628
1987 Mes-Masson AM, Witte ON. Role of the abl oncogene in chronic myelogenous leukemia Advances in Cancer Research. 49: 53-74. PMID 3314397 DOI: 10.1016/S0065-230X(08)60794-0  0.305
1987 Pendergast AM, Traugh JA, Witte ON. Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. Molecular and Cellular Biology. 7: 4280-9. PMID 3125421 DOI: 10.1128/Mcb.7.12.4280  0.714
1987 Daley GQ, McLaughlin J, Witte ON, Baltimore D. The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts Science. 237: 532-535. PMID 2440107 DOI: 10.1126/Science.2440107  0.604
1987 Hunt P, Robertson D, Weiss D, Rennick D, Lee F, Witte ON. A single bone marrow-derived stromal cell type supports the in vitro growth of early lymphoid and myeloid cells Cell. 48: 997-1007. PMID 2435412 DOI: 10.1016/0092-8674(87)90708-2  0.327
1986 Schwartz RC, Stanton LW, Marcu KB, Witte ON. An in vitro model for tumor progression in murine lymphoid cells Current Topics in Microbiology and Immunology. 132: 75-80. PMID 3491739 DOI: 10.1007/978-3-642-71562-4_10  0.317
1986 Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science (New York, N.Y.). 233: 212-4. PMID 3460176 DOI: 10.1126/Science.3460176  0.594
1986 Kozbor D, Giallongo A, Sierzega ME, Konopka JB, Witte ON, Showe LC, Croce CM. Expression of a translocated c-abl gene in hybrids of mouse fibroblasts and chronic myelogenous leukaemia cells. Nature. 319: 331-3. PMID 3455750 DOI: 10.1038/319331A0  0.312
1986 Denis KA, Witte ON. In vitro development of B lymphocytes from long-term cultured precursor cells Proceedings of the National Academy of Sciences of the United States of America. 83: 441-445. PMID 3079911 DOI: 10.1073/Pnas.83.2.441  0.327
1986 Konopka JB, Clark S, McLaughlin J, Nitta M, Kato Y, Strife A, Clarkson B, Witte ON. Variable expression of the translocated c-abl oncogene in Philadelphia-chromosome-positive B-lymphoid cell lines from chronic myelogenous leukemia patients Proceedings of the National Academy of Sciences of the United States of America. 83: 4049-4052. PMID 3012546 DOI: 10.1073/Pnas.83.11.4049  0.33
1986 Pillemer EA, Kooistra DA, Witte ON, Weissman IL. Monoclonal antibody to the amino-terminal L sequence of murine leukemia virus glycosylated gag polyproteins demonstrates their unusual orientation in the cell membrane Journal of Virology. 57: 413-421. PMID 2418213 DOI: 10.1128/Jvi.57.2.413-421.1986  0.441
1985 Davis RL, Konopka JB, Witte ON. Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties Molecular and Cellular Biology. 5: 204-213. PMID 4039028 DOI: 10.1128/Mcb.5.1.204  0.331
1985 Whitlock C, Denis K, Robertson D, Witte O. In vitro analysis of murine B-cell development Annual Review of Immunology. 3: 213-235. PMID 3904770 DOI: 10.1146/Annurev.Iy.03.040185.001241  0.386
1985 Konopka JB, Witte ON. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products Molecular and Cellular Biology. 5: 3116-3123. PMID 3879812 DOI: 10.1128/Mcb.5.11.3116  0.333
1985 Whitlock CA, Witte ON. The complexity of virus-cell interactions in Abelson virus infection of lymphoid and other hematopoietic cells Advances in Immunology. 74-98. DOI: 10.1016/S0065-2776(08)60338-7  0.371
1984 Konopka JB, Davis RL, Watanabe SM, Ponticelli AS, Schiff-Maker L, Rosenberg N, Witte ON. Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity Journal of Virology. 51: 223-232. PMID 6610061 DOI: 10.1128/Jvi.51.1.223-232.1984  0.313
1984 Whitlock CA, Robertson D, Witte ON. Murine B cell lymphopoiesis in long term culture Journal of Immunological Methods. 67: 353-369. PMID 6608556 DOI: 10.1016/0022-1759(84)90475-7  0.35
1984 Denis KA, Treiman LJ, St. Claire JI, Witte ON. Long-term cultures of murine fetal liver retain very early B lymphoid phenotype Journal of Experimental Medicine. 160: 1087-1101. PMID 6434687 DOI: 10.1084/Jem.160.4.1087  0.315
1984 Kurland JI, Ziegler SF, Witte ON. Long-term cultured B lymphocytes and their precursors reconstitute the B-lymphocyte lineage in vivo Proceedings of the National Academy of Sciences of the United States of America. 81: 7554-7558. PMID 6334312 DOI: 10.1073/Pnas.81.23.7554  0.353
1984 Kurland JI, Witte ON. Development of cells of the B-lymphocyte lineage in longterm culture Current Topics in Microbiology and Immunology. 113: 217-223. PMID 6332717 DOI: 10.1007/978-3-642-69860-6_37  0.334
1984 Ziegler SF, Treiman LJ, Witte ON. kappa gene diversity among the clonal progeny of pre-B lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 81: 1529-1533. PMID 6324199 DOI: 10.1073/Pnas.81.5.1529  0.307
1984 Konopka JB, Watanabe SM, Witte ON. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity Cell. 37: 1035-1042. PMID 6204766 DOI: 10.1016/0092-8674(84)90438-0  0.323
1983 Whitlock CA, Ziegler SF, Witte ON. Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes Molecular and Cellular Biology. 3: 596-604. PMID 6304498 DOI: 10.1128/Mcb.3.4.596  0.376
1983 Witte ON. Molecular and cellular biology of Abelson virus transformation Current Topics in Microbiology and Immunology. 103: 127-146. PMID 6303708 DOI: 10.1007/978-3-642-68943-7_6  0.307
1983 Whitlock CA, Ziegler SF, Treiman LJ, Stafford JI, Witte ON. Differentiation of cloned populations of immature B cells after transformation with abelson murine leukemia virus Cell. 32: 903-911. PMID 6299581 DOI: 10.1016/0092-8674(83)90075-2  0.329
1982 Whitlock CA, Witte ON. Long-term culture of B lymphocytes and their precursors from murine bone marrow Proceedings of the National Academy of Sciences of the United States of America. 79: 3608-3612. PMID 6980414 DOI: 10.1073/Pnas.79.11.3608  0.339
1982 Ponticelli AS, Whitlock CA, Rosenberg N, Witte ON. In vivo tyrosine phosphorylations of the abelson virus transforming protein are absent in its normal cellular homolog Cell. 29: 953-960. PMID 6185233 DOI: 10.1016/0092-8674(82)90458-5  0.309
1981 Witte ON, Ponticelli A, Gifford A, Baltimore D, Rosenberg N, Elder J. Phosphorylation of the Abelson murine leukemia virus transforming protein Journal of Virology. 39: 870-878. PMID 6270355 DOI: 10.1128/Jvi.39.3.870-878.1981  0.474
1981 Goff SP, Witte ON, Gilboa E, Rosenberg N, Baltimore D. Genome structure of Abelson murine leukemia virus variants: proviruses in fibroblasts and lymphoid cells. Journal of Virology. 38: 460-8. PMID 6264122 DOI: 10.1128/Jvi.38.2.460-468.1981  0.54
1981 Ziegler SF, Whitlock CA, Goff SP, Gifford A, Witte ON. Lethal effect of the abelson murine leukemia virus transforming gene product Cell. 27: 477-486. PMID 6101202 DOI: 10.1016/0092-8674(81)90389-5  0.343
1980 Goff SP, Gilboa E, Witte ON, Baltimore D. Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell. 22: 777-85. PMID 6257398 DOI: 10.1016/0092-8674(80)90554-1  0.52
1980 Witte ON, Goff S, Rosenberg N, Baltimore D. A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 77: 4993-7. PMID 6254050 DOI: 10.1073/Pnas.77.8.4993  0.591
1980 Baltimore D, Shields A, Otto G, Goff S, Besmer P, Witte O, Rosenberg N. Structure and expression of the Abelson murine leukemia virus genome and its relationship to a normal cell gene. Cold Spring Harbor Symposia On Quantitative Biology. 44: 849-54. PMID 6253217 DOI: 10.1101/Sqb.1980.044.01.090  0.585
1980 Witte ON, Dasgupta A, Baltimore D. Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine Nature. 283: 826-831. PMID 6244493 DOI: 10.1038/283826a0  0.383
1980 Rotter V, Witte ON, Coffman R, Baltimore D. Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50 Journal of Virology. 36: 547-555. PMID 6159484 DOI: 10.1128/Jvi.36.2.547-555.1980  0.499
1979 Rosenberg N, Witte ON, Baltimore D. Characterization of Abelson murine leukemia virus isolates differing in P120 expression Symposia On Quantitative Biology. 44: 859-864. PMID 6253219 DOI: 10.1101/Sqb.1980.044.01.092  0.431
1979 Witte ON, Sun L, Rosenberg N, Baltimore D. A trans-acting protein kinase identified in cells transformed by Abelson murine leukemia virus Symposia On Quantitative Biology. 44: 855-857. PMID 6253218 DOI: 10.1101/Sqb.1980.044.01.091  0.5
1979 Baltimore D, Rosenberg N, Witte ON. Transformation of immature lymphoid cells by Abelson murine leukemia virus Immunological Reviews. 48: 3-22. PMID 397920 DOI: 10.1111/J.1600-065X.1979.Tb00296.X  0.406
1979 Witte ON, Rosenberg N, Baltimore D. Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface Journal of Virology. 31: 776-784. PMID 92572 DOI: 10.1128/Jvi.31.3.776-784.1979  0.4
1979 Witte ON, Rosenberg NE, Baltimore D. A normal cell protein cross-reactive to the major Abelson murine leukaemia virus gene product Nature. 281: 396-398. PMID 90344 DOI: 10.1038/281396A0  0.414
1978 Witte ON, Rosenberg N, Paskind M, Shields A, Baltimore D. Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells Proceedings of the National Academy of Sciences of the United States of America. 75: 2488-2492. PMID 209468 DOI: 10.1073/Pnas.75.5.2488  0.474
1978 Hale AH, Witte ON, Baltimore D, Eisen HN. Vesicular stomatitis virus glycoprotein is necessary for H 2 restricted lysis of infected cells by cytotoxic T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 75: 970-974. PMID 204941 DOI: 10.1073/Pnas.75.2.970  0.484
1978 Shields A, Witte ON, Rothenberg E, Baltimore D. High frequency of aberrant expression of moloney murine leukemia virus in clonal infections Cell. 14: 601-609. PMID 80281 DOI: 10.1016/0092-8674(78)90245-3  0.501
1978 Witte ON, Baltimore D. Relationship of retrovirus polyprotein cleavages to virion maturation studied with temperature-sensitive murine leukemia virus mutants Journal of Virology. 26: 750-761. PMID 78989 DOI: 10.1128/Jvi.26.3.750-761.1978  0.449
1977 Witte ON, Baltimore D. Mechanism of formation of pseudotypes between vesicular stomatitis virus and murine leukemia virus Cell. 11: 505-511. PMID 195740 DOI: 10.1016/0092-8674(77)90068-X  0.358
1977 Witte ON, Tsukamoto-Adey A, Weissman IL. Cellular maturation of oncornavirus glycoproteins: Topological arrangement of precursor and product forms in cellular membranes Virology. 76: 539-553. PMID 190766 DOI: 10.1016/0042-6822(77)90236-7  0.329
1976 Witte ON, Weissman IL. Oncornavirus budding: Kinetics of formation and utilization of viral membrane glycoprotein Virology. 69: 464-473. PMID 176781 DOI: 10.1016/0042-6822(76)90477-3  0.338
1973 Witte ON, Weissman IL, Kaplan HS. Structural characteristics of some murine RNA tumor viruses studied by lactoperoxidase iodination Proceedings of the National Academy of Sciences of the United States of America. 70: 36-40. PMID 4346036 DOI: 10.1073/Pnas.70.1.36  0.396
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