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Lewis C. Cantley, Ph.D. - Publications

Affiliations: 
Systems Biology Harvard University, Cambridge, MA, United States 
Area:
PI3K and cancer metabolism
Website:
http://www.fas.harvard.edu/~biophys/Lewis_Cantley.htm

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Queiroz AL, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica ERM, Liang RJ, Murphy J, Holman CD, Bare CJ, Ghahramani G, Wu Z, Cohen DE, Kirwan JP, Cantley LC, et al. Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nature Communications. 13: 4633. PMID 35941104 DOI: 10.1038/s41467-022-32135-0  0.686
2022 Dibble CC, Barritt SA, Perry GE, Lien EC, Geck RC, DuBois-Coyne SE, Bartee D, Zengeya TT, Cohen EB, Yuan M, Hopkins BD, Meier JL, Clohessy JG, Asara JM, Cantley LC, et al. PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature. PMID 35896750 DOI: 10.1038/s41586-022-04984-8  0.826
2022 Yoshida T, Kawabe T, Cantley LC, Lyssiotis CA. Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP-Dependent Malic Enzyme 1. Biochemistry. 61: 1548-1553. PMID 35819845 DOI: 10.1021/acs.biochem.2c00123  0.548
2022 Taylor SR, Falcone JN, Cantley LC, Goncalves MD. Developing dietary interventions as therapy for cancer. Nature Reviews. Cancer. PMID 35614234 DOI: 10.1038/s41568-022-00485-y  0.756
2022 Davdison SM, Schmidt DR, Heyman JE, O'Brien JP, Liu AC, Israelsen WJ, Dayton TL, Sehgal R, Bronson RT, Freinkman E, Mak HH, Fanelli GN, Malstrom S, Bellinger G, Carracedo A, ... ... Cantley LC, et al. Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma. Cancer Research. PMID 35584006 DOI: 10.1158/0008-5472.CAN-21-2352  0.722
2022 Gomes AP, Ilter D, Low V, Drapela S, Schild T, Mullarky E, Han J, Elia I, Broekaert D, Rosenzweig A, Nagiec M, Nunes JB, Schaffer BE, Mutvei AP, Asara JM, ... Cantley LC, et al. Altered propionate metabolism contributes to tumour progression and aggressiveness. Nature Metabolism. PMID 35361954 DOI: 10.1038/s42255-022-00553-5  0.322
2022 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Posada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Cantley LC, et al. Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Nature Cancer. 2: 1243. PMID 35122065 DOI: 10.1038/s43018-021-00283-9  0.635
2021 Taylor SR, Ramsamooj S, Liang RJ, Katti A, Pozovskiy R, Vasan N, Hwang SK, Nahiyaan N, Francoeur NJ, Schatoff EM, Johnson JL, Shah MA, Dannenberg AJ, Sebra RP, Dow LE, ... Cantley LC, et al. Dietary fructose improves intestinal cell survival and nutrient absorption. Nature. PMID 34408323 DOI: 10.1038/s41586-021-03827-2  0.763
2021 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply. Molecular Cell. 81: 3031. PMID 34270944 DOI: 10.1016/j.molcel.2021.06.029  0.518
2021 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Cantley LC, et al. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Nature Cancer. 2: 414-428. PMID 34179825 DOI: 10.1038/s43018-021-00183-y  0.653
2021 Liang RJ, Taylor S, Nahiyaan N, Song J, Murphy CJ, Dantas E, Cheng S, Hsu TW, Ramsamooj S, Grover R, Hwang SK, Ngo B, Cantley LC, Rhee KY, Goncalves MD. GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase. Cancer & Metabolism. 9: 12. PMID 33762003 DOI: 10.1186/s40170-021-00246-9  0.804
2021 Hwang I, Uchida H, Dai Z, Li F, Sanchez T, Locasale JW, Cantley LC, Zheng H, Paik J. Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification. Nature Communications. 12: 640. PMID 33510167 DOI: 10.1038/s41467-020-20839-0  0.731
2020 Jeong S, Savino AM, Chirayil R, Barin E, Cheng Y, Park SM, Schurer A, Mullarky E, Cantley LC, Kharas MG, Keshari KR. High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. Cell Metabolism. PMID 33357456 DOI: 10.1016/j.cmet.2020.12.005  0.316
2020 Gomes AP, Ilter D, Low V, Endress JE, Fernández-García J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, ... ... Cantley LC, et al. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. PMID 32814897 DOI: 10.1038/S41586-020-2630-0  0.333
2020 Goncalves MD, Cantley LC. A 'fast'er way to treat breast cancer. Nature Metabolism. 2: 559-560. PMID 32694797 DOI: 10.1038/s42255-020-0225-6  0.665
2020 Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, ... ... Cantley LC, et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery. PMID 32571778 DOI: 10.1158/2159-8290.Cd-19-1228  0.795
2020 Liu H, Paddock MN, Wang H, Murphy CJ, Geck RC, Navarro AJ, Wulf GM, Elemento O, Haucke V, Cantley LC, Toker A. The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. Cancer Discovery. PMID 32513774 DOI: 10.1158/2159-8290.Cd-19-1262  0.616
2020 Noch EK, Yim I, Milner TA, Cantley LC. Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain. The Journal of Comparative Neurology. PMID 32449185 DOI: 10.1002/Cne.24956  0.328
2020 Balasuriya N, Davey NE, Johnson JL, Liu H, Biggar KK, Cantley LC, Li SS, O'Donoghue P. Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1). The Journal of Biological Chemistry. PMID 32350110 DOI: 10.1074/Jbc.Ra119.012425  0.416
2020 Manz TD, Sivakumaren SC, Ferguson FM, Zhang T, Yasgar A, Seo HS, Ficarro SB, Card JD, Shim H, Miduturu CV, Simeonov A, Shen M, Marto JA, Dhe-Paganon S, Hall MD, ... Cantley LC, et al. Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 32298120 DOI: 10.1021/Acs.Jmedchem.0C00227  0.389
2020 Manz TD, Sivakumaren SC, Yasgar A, Hall MD, Davis MI, Seo HS, Card JD, Ficarro SB, Shim H, Marto JA, Dhe-Paganon S, Sasaki AT, Boxer MB, Simeonov A, Cantley LC, et al. Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Acs Medicinal Chemistry Letters. 11: 346-352. PMID 32184968 DOI: 10.1021/Acsmedchemlett.9B00402  0.368
2020 Robert T, Johnson JL, Guichaoua R, Yaron TM, Bach S, Cantley LC, Colas P. Development of a CDK10/CycM Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Frontiers in Chemistry. 8: 147. PMID 32175313 DOI: 10.3389/Fchem.2020.00147  0.394
2020 Sivakumaren SC, Shim H, Zhang T, Ferguson FM, Lundquist MR, Browne CM, Seo HS, Paddock MN, Manz TD, Jiang B, Hao MF, Krishnan P, Wang DG, Yang TJ, Kwiatkowski NP, ... ... Cantley LC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chemical Biology. PMID 32130941 DOI: 10.1016/J.Chembiol.2020.02.003  0.39
2020 Hopkins BD, Goncalves MD, Cantley LC. Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer. Nature Reviews. Endocrinology. PMID 32127696 DOI: 10.1038/S41574-020-0329-9  0.774
2020 Lee EK, Tan-Wasielewski Z, Aghajanian C, Coleman RL, Curtis J, Hirsch MS, Matulonis UA, Cantley LC, Mills GB, Doyle LA, Liu JF. Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035). Gynecologic Oncology Reports. 32: 100546. PMID 32083163 DOI: 10.1016/J.Gore.2020.100546  0.317
2020 Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, ... ... Cantley LC, et al. Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy. Cancer & Metabolism. 8: 1. PMID 31908776 DOI: 10.1186/S40170-019-0202-2  0.789
2020 Vasan N, Razavi P, Johnson JL, Shao H, Wilson T, Schimmoller F, Shah H, Antoine A, Ladewig E, Gorelick A, Lin T, Toska E, Xu G, Kazmi A, Chang MT, ... ... Cantley LC, et al. Abstract P3-03-01: Double PIK3CA mutations in cis drive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P3-03-01  0.342
2020 Lee K, Guerrero-Zotano A, Hanker A, Servetto A, Sudhan D, Formisano L, Jansen V, González-Ericsson P, Sanders M, Stricker T, Cantley L, Arteaga C. Abstract GS6-06: A neoadjuvant trial with letrozole identifies PRR11 in the 17q23 amplicon as a mechanism of resistance to endocrine therapy in ER-positive breast cancer Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-Gs6-06  0.385
2019 Stein BD, Calzolari D, Hellberg K, Hu YS, He L, Hung CM, Toyama EQ, Ross DS, Lillemeier BF, Cantley LC, Yates JR, Shaw RJ. Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. Cell Reports. 29: 3331-3348.e7. PMID 31801093 DOI: 10.1016/J.Celrep.2019.10.117  0.409
2019 Yoshida T, Yamasaki S, Kaneko O, Taoka N, Tomimoto Y, Namatame I, Yahata T, Kuromitsu S, Cantley LC, Lyssiotis CA. A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth. Biochemical and Biophysical Research Communications. PMID 31787239 DOI: 10.1016/J.Bbrc.2019.11.130  0.637
2019 Myers AP, Konstantinopoulos PA, Barry WT, Luo W, Broaddus RR, Makker V, Drapkin R, Liu J, Doyle A, Horowitz NS, Meric-Bernstam F, Birrer M, Aghajanian C, Coleman RL, Mills GB, ... Cantley LC, et al. Phase II, 2-Stage, 2-Arm, PIK3CA Mutation Stratified Trial of MK-2206 in Recurrent Endometrial Cancer. International Journal of Cancer. PMID 31714586 DOI: 10.1002/Ijc.32783  0.36
2019 Vasan N, Razavi P, Johnson JL, Shao H, Shah H, Antoine A, Ladewig E, Gorelick A, Lin TY, Toska E, Xu G, Kazmi A, Chang MT, Taylor BS, Dickler MN, ... ... Cantley LC, et al. Double mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. Science (New York, N.Y.). 366: 714-723. PMID 31699932 DOI: 10.1126/Science.Aaw9032  0.345
2019 Mullarky E, Xu J, Robin AD, Huggins DJ, Jennings A, Noguchi N, Olland A, Lakshminarasimhan D, Miller M, Tomita D, Michino M, Su T, Zhang G, Stamford AW, Meinke PT, ... ... Cantley LC, et al. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 31327531 DOI: 10.1016/J.Bmcl.2019.07.011  0.402
2019 Xing Y, Lin NU, Maurer MA, Chen H, Mahvash A, Sahin A, Akcakanat A, Li Y, Abramson V, Litton J, Chavez-MacGregor M, Valero V, Piha-Paul SA, Hong D, Do KA, ... ... Cantley LC, et al. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Research : Bcr. 21: 78. PMID 31277699 DOI: 10.1186/S13058-019-1154-8  0.329
2019 Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, ... Cantley LC, et al. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 35: 916-931.e9. PMID 31185214 DOI: 10.1016/J.Ccell.2019.05.002  0.606
2019 Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC. PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell Reports. 27: 1991-2001.e5. PMID 31091439 DOI: 10.1016/J.Celrep.2019.04.070  0.375
2019 Ngo B, Van Riper JM, Cantley LC, Yun J. Targeting cancer vulnerabilities with high-dose vitamin C. Nature Reviews. Cancer. PMID 30967651 DOI: 10.1038/S41568-019-0135-7  0.778
2019 Liu C, Knudsen GM, Pedley AM, He J, Johnson JL, Yaron TM, Cantley LC, Benkovic SJ. Mapping post-translational modifications of de novo purine biosynthetic enzymes: Implications for pathway regulation. Journal of Proteome Research. PMID 30964683 DOI: 10.1021/Acs.Jproteome.8B00969  0.405
2019 Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chemical Biology. PMID 30930164 DOI: 10.1016/J.Chembiol.2019.02.015  0.393
2019 Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, ... ... Cantley LC, et al. High-fructose corn syrup enhances intestinal tumor growth in mice. Science (New York, N.Y.). 363: 1345-1349. PMID 30898933 DOI: 10.1126/Science.Aat8515  0.79
2019 Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, ... ... Cantley LC, et al. Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. The Lancet. Oncology. PMID 30880072 DOI: 10.1016/S1470-2045(18)30905-7  0.332
2019 Zheng Y, Ramsamooj S, Li Q, Johnson JL, Yaron TM, Sharra K, Cantley LC. Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase. Scientific Reports. 9: 4190. PMID 30862944 DOI: 10.1038/S41598-019-40950-7  0.404
2019 Paddock MN, Field SJ, Cantley LC. Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance. Journal of Lipid Research. PMID 30718284 DOI: 10.1194/Jlr.S092130  0.741
2019 Hodakoski C, Hopkins BD, Zhang G, Su T, Cheng Z, Morris R, Rhee KY, Goncalves MD, Cantley LC. Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer. Cancers. 11. PMID 30609754 DOI: 10.3390/Cancers11010037  0.754
2019 Goncalves M, Lu C, Hartman T, Hwang S, Pauli C, Taylor S, Gross S, Rhee K, Cantley L, Yun J. SAT-LB057 High-Fructose Corn Syrup Enhances Intestinal Tumor Growth in Mice Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Sat-Lb057  0.706
2019 Vasan N, Razavi P, Johnson J, Shao H, Shah H, Antoine A, Ladewig E, Gorelick A, Toska E, Xu G, Kazmi A, Chang MT, Taylor BS, Dickler MN, Jhaveri K, ... ... Cantley LC, et al. Abstract 3917: DoublePIK3CAmutations incisenhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer Cancer Research. 79: 3917-3917. DOI: 10.1158/1538-7445.Am2019-3917  0.347
2019 Noch E, Yim I, Cantley L. P11.63 PI3K inhibition in conjunction with the ketogenic diet reduces growth and neuroinflammation in pediatric high-grade glioma Neuro-Oncology. 21: iii58-iii58. DOI: 10.1093/Neuonc/Noz126.209  0.345
2019 Vasan N, Razavi P, Johnson J, Shao H, Reznik E, Smith M, Sebra R, Cantley L, Scaltriti M, Baselga J. Double PIK3CA mutations in cis enhance PI3Kα oncogene activation and sensitivity to PI3Kα inhibitors in breast cancer Annals of Oncology. 30: iii1. DOI: 10.1093/Annonc/Mdz095  0.303
2018 Zheng Y, Cantley LC. Toward a better understanding of folate metabolism in health and disease. The Journal of Experimental Medicine. PMID 30587505 DOI: 10.1084/Jem.20181965  0.322
2018 Browne CM, Jiang B, Ficarro SB, Doctor ZM, Johnson JL, Card JD, Sivakumaren SC, Alexander WM, Yaron T, Murphy CJ, Kwiatkowski NP, Zhang T, Cantley LC, Gray NS, Marto JA. A Chemoproteomic Strategy for Direct and Proteome-wide Covalent Inhibitor Target-site Identification. Journal of the American Chemical Society. PMID 30518210 DOI: 10.1021/Jacs.8B07911  0.332
2018 Zheng Y, Lin TY, Lee G, Paddock MN, Momb J, Cheng Z, Li Q, Fei DL, Stein BD, Ramsamooj S, Zhang G, Blenis J, Cantley LC. Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Cell. 175: 1546-1560.e17. PMID 30500537 DOI: 10.1016/J.Cell.2018.09.041  0.362
2018 Goncalves MD, Hopkins BD, Cantley LC. Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer. The New England Journal of Medicine. 379: 2052-2062. PMID 30462943 DOI: 10.1056/Nejmra1704560  0.751
2018 Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Biochemical Characterization and Structure-based Mutational Analysis Provides Insight into Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. PMID 30365304 DOI: 10.2210/Pdb6Dnd/Pdb  0.815
2018 Cohen SB, Bainter W, Johnson JL, Lin TY, Wong JCY, Wallace J, Jones J, Mir F, Qamar F, Cantley LC, Geha RS, Chou J. Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant. The Journal of Allergy and Clinical Immunology. PMID 30336224 DOI: 10.1016/J.Jaci.2018.10.005  0.331
2018 Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, ... ... Cantley LC, et al. Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. PMID 30158705 DOI: 10.1038/S41586-018-0506-3  0.698
2018 Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, ... ... Cantley LC, et al. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. PMID 30051890 DOI: 10.1038/S41586-018-0343-4  0.729
2018 Goncalves MD, Cantley LC. A Glycolysis Outsider Steps into the Cancer Spotlight. Cell Metabolism. 28: 3-4. PMID 29972796 DOI: 10.1016/J.Cmet.2018.06.017  0.729
2018 DelNero P, Hopkins BD, Cantley LC, Fischbach C. Cancer metabolism gets physical. Science Translational Medicine. 10. PMID 29794058 DOI: 10.1126/Scitranslmed.Aaq1011  0.304
2018 Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorganic & Medicinal Chemistry Letters. PMID 29731362 DOI: 10.1016/J.Bmcl.2018.04.061  0.621
2018 Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, ... ... Cantley LC, et al. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular Cell. 70: 531-544.e9. PMID 29727621 DOI: 10.1016/J.Molcel.2018.03.037  0.752
2018 Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, ... ... Cantley LC, et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. PMID 29342134 DOI: 10.1038/Nature25432  0.735
2018 Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311302 DOI: 10.1073/Pnas.1714703115  0.703
2018 Triscott J, Benelli M, Sailer V, Prandi D, Emerling B, Demichelis F, Cantley L, Rubin MA. Abstract A078: Towards understanding noncanonical phosphatidylinositol kinases in the maintenance of prostate metabolism Cancer Research. 78. DOI: 10.1158/1538-7445.Prca2017-A078  0.383
2018 Bakhoum SF, Ngo B, Bakhoum AL, Cavallo J, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBk, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, ... ... Cantley LC, et al. Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ng03  0.347
2018 Cantley LC. Abstract KN01: Keynote Lecture: PI 3-kinase links obesity, insulin resistance, and cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Kn01  0.374
2017 Croessmann S, Sheehan JH, Lee KM, Sliwoski GR, He J, Nagy RJ, Riddle DA, Mayer IA, Balko JM, Lanman RB, Miller V, Cantley LC, Meiler J, Arteaga CL. PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29284706 DOI: 10.1158/1078-0432.Ccr-17-2141  0.327
2017 Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discovery. PMID 29203461 DOI: 10.1158/2159-8290.Cd-17-0679  0.6
2017 Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, ... ... Cantley LC, et al. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. PMID 29153836 DOI: 10.1016/J.Cell.2017.10.037  0.413
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Cantley LC, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 392. PMID 28898700 DOI: 10.1016/J.Ccell.2017.08.008  0.796
2017 Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. The PI3K Pathway in Human Disease. Cell. 170: 605-635. PMID 28802037 DOI: 10.1016/J.Cell.2017.07.029  0.414
2017 Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Reports. 20: 721-736. PMID 28723573 DOI: 10.1016/J.Celrep.2017.06.074  0.633
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Cantley LC, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 71-87.e7. PMID 28697344 DOI: 10.1016/J.Ccell.2017.06.004  0.807
2017 Thorpe LM, Spangle JM, Ohlson CE, Cheng H, Roberts TM, Cantley LC, Zhao JJ. PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630349 DOI: 10.1073/Pnas.1704706114  0.363
2017 Waldhart AN, Dykstra H, Peck AS, Boguslawski EA, Madaj ZB, Wen J, Veldkamp K, Hollowell M, Zheng B, Cantley LC, McGraw TE, Wu N. Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. Cell Reports. 19: 2005-2013. PMID 28591573 DOI: 10.1016/J.Celrep.2017.05.041  0.329
2017 Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR. Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. The Journal of Biological Chemistry. 292: 5608. PMID 28363934 DOI: 10.1074/Jbc.A117.305602  0.821
2017 Gupta A, Anjomani-Virmouni S, Koundouros N, Dimitriadi M, Choo-Wing R, Valle A, Zheng Y, Chiu YH, Agnihotri S, Zadeh G, Asara JM, Anastasiou D, Arends MJ, Cantley LC, Poulogiannis G. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Molecular Cell. 65: 999-1013.e7. PMID 28306514 DOI: 10.1016/J.Molcel.2017.02.019  0.386
2017 Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, ... ... Cantley LC, et al. Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Anti-Tumor Innate Immunity. Cancer Discovery. PMID 28274958 DOI: 10.1158/2159-8290.Cd-16-0778  0.377
2017 Mathur D, Stratikopoulos E, Ozturk S, Steinbach N, Pegno S, Schoenfeld S, Yong R, Murty VV, Asara JM, Cantley LC, Parsons R. PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition. Cancer Discovery. PMID 28255082 DOI: 10.1158/2159-8290.Cd-16-0612  0.403
2017 de Oliveira Taveira M, Nabavi S, Wang Y, Tonellato P, Esteva FJ, Cantley LC, Wulf GM. Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer. Journal of Cancer Research and Clinical Oncology. PMID 28247034 DOI: 10.1007/S00432-017-2358-X  0.351
2017 Trousil S, Chen S, Mu C, Shaw FM, Yao Z, Ran Y, Shakuntala T, Merghoub T, Manstein D, Rosen N, Cantley LC, Zippin JH, Zheng B. Phenformin enhances the efficacy of ERK inhibition in NF1-mutant melanoma. The Journal of Investigative Dermatology. PMID 28143781 DOI: 10.1016/J.Jid.2017.01.013  0.346
2017 You MH, Kim BM, Chen CH, Begley MJ, Cantley LC, Lee TH. Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death. Cell Death and Differentiation. 24: 238-250. PMID 28141794 DOI: 10.1038/Cdd.2016.114  0.346
2017 Ravez S, Corbet C, Spillier Q, Dutu A, Robin AD, Mullarky E, Cantley LC, Feron O, Frédérick R. α-Ketothioamide derivatives: a promising tool to interrogate the phosphoglycerate dehydrogenase (PHGDH). Journal of Medicinal Chemistry. PMID 28085281 DOI: 10.1021/Acs.Jmedchem.6B01166  0.326
2017 Li M, Chiang Y, Lyssiotis C, Teater M, Shen H, Wang L, Hong JY, Jin H, Duy C, Mistry S, Cerchietti L, Cross J, Cantley L, Lin H, Melnick A. SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls Blood. 130: 643-643. DOI: 10.1182/Blood.V130.Suppl_1.643.643  0.634
2017 Croessmann S, Sheehan J, Sliwoski G, Leelatian N, He J, Nagy R, Balko JM, Mayer IA, Lanman RB, Miller V, Cantley LC, Irish JM, Meiler J, Arteaga CL. Abstract 1772:PIK3CAC2 domain deletions hyperactivate PI3K, generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors Cancer Research. 77: 1772-1772. DOI: 10.1158/1538-7445.Am2017-1772  0.304
2017 Bakhoum S, Ngo B, Bakhoum A, Cavallo-Fleming J, Murphy C, Powell S, Cantley L. Radiation-Induced Activation of Innate Immune Pathways from Errors in Mitosis International Journal of Radiation Oncology*Biology*Physics. 99: S201. DOI: 10.1016/J.Ijrobp.2017.06.500  0.731
2016 Matulonis UA, Wulf GM, Barry WT, Birrer M, Westin SN, Farooq S, Bell-McGuinn KM, Obermayer E, Whalen C, Spagnoletti T, Luo W, Liu H, Hok RC, Aghajanian C, Solit DB, ... ... Cantley LC, et al. Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high grade serous ovarian and breast cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 27993796 DOI: 10.1093/Annonc/Mdw672  0.3
2016 Hopkins BD, Goncalves MD, Cantley LC. Obesity and Cancer Mechanisms: Cancer Metabolism. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 34: 4277-4283. PMID 27903152 DOI: 10.1200/Jco.2016.67.9712  0.708
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27706144 DOI: 10.1038/nature19851  0.79
2016 Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA. A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. Molecular & Cellular Oncology. 3: e1164280. PMID 27652319 DOI: 10.1080/23723556.2016.1164280  0.642
2016 Lien EC, Lyssiotis CA, Cantley LC. Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 207: 39-72. PMID 27557534 DOI: 10.1007/978-3-319-42118-6_3  0.822
2016 Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 27528663 DOI: 10.1073/Pnas.1606862113  0.417
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27509858 DOI: 10.1038/Nature19084  0.806
2016 Cantley LC. Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley. Disease Models & Mechanisms. 9: 911-6. PMID 27491070 DOI: 10.1242/Dmm.026856  0.426
2016 Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402769 DOI: 10.1073/Pnas.1522223113  0.788
2016 Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Proceedings of the National Academy of Sciences of the United States of America. PMID 27313209 DOI: 10.1073/Pnas.1600934113  0.711
2016 Mayer IA, Abramson V, Formisano L, Balko JM, Estrada MV, Sanders M, Juric D, Solit D, Berger MF, Won H, Li Y, Cantley LC, Winer EP, Arteaga CL. A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-specific Inhibitor, with Letrozole in ER+/HER2-Negative Metastatic Breast Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27126994 DOI: 10.1158/1078-0432.Ccr-16-0134  0.316
2016 Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology. PMID 27088857 DOI: 10.1038/Ncb3341  0.817
2016 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. 48: 473. PMID 27023779 DOI: 10.1038/Ng0329-473A  0.64
2016 Mullarky E, Lucki NC, Zavareh RB, Anglin JL, Gomes AP, Nicolay BN, Wong JCY, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, ... ... Cantley LC, et al. Erratum: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (1778-1783) DOI:10.1073/pnas.1521548113) Proceedings of the National Academy of Sciences of the United States of America. 113. PMID 26951666 DOI: 10.1073/Pnas.1602228113  0.655
2016 Breitkopf SB, Yang X, Begley MJ, Kulkarni M, Chiu YH, Turke AB, Lauriol J, Yuan M, Qi J, Engelman JA, Hong P, Kontaridis MI, Cantley LC, Perrimon N, Asara JM. A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2. Scientific Reports. 6: 20471. PMID 26839216 DOI: 10.1038/Srep20471  0.367
2016 Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, ... ... Cantley LC, et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831078 DOI: 10.1073/Pnas.1521548113  0.785
2016 Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, ... ... Cantley LC, et al. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 164: 433-446. PMID 26824656 DOI: 10.1186/2049-3002-2-S1-P86  0.817
2016 Di Liberto M, Huang X, Elemento O, Eng K, Blum KA, Bartlett NL, Park SI, Ruan J, Maddocks KJ, Inghirami G, Cantley L, Leonard JP, Martin P, Chen-Kiang S. PIK3IP1 Inhibition of PI3K in G1 Arrest Induced By CDK4 Inhibition Reprograms MCL for Ibrutinib Therapy Blood. 128: 610-610. DOI: 10.1182/Blood.V128.22.610.610  0.358
2016 Wulf GM, Juvekar A, Cantley LC, Matulonis UA. Abstract IA08: PI3K- and PARP-inhibitors for the treatment of women cancers. Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Ovca15-Ia08  0.371
2016 Chen-Kiang S, Liberto MD, Vijay P, Chiron D, Huang X, Ely S, Elemento O, Mason C, Cantley L, Leonard JP, Martin P. Abstract IA08: Reprogramming human cancer cells in CDK4/6 inhibitor therapy Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Cellcycle16-Ia08  0.385
2016 Balko J, Hicks M, Berger M, Solit D, Bouvier N, Sanders M, Estrada M, Won H, Cantley L, Mayer I, Arteaga C. Abstract P3-07-41: Genomic alterations indicative of a luminal A subtype associate with clinical benefit to buparlisib and letrozole in endocrine-resistant ER+/HER2– metastatic breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-07-41  0.365
2016 DeNicola GM, Chen P, Mullarky E, Chio C, Asara JM, Minna JD, Tuveson DA, DeBerardinis RJ, Cantley LC. Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B04  0.769
2016 Cantley LC. Abstract SY12-01: PI 3-kinase and cancer metabolism Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Sy12-01  0.437
2016 Patnaik A, Swanson KD, Csizmadia E, Gehring MP, Helenius K, Pyzer AR, Wang LC, Novak J, Elemento O, Thornley TB, Asara JM, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, ... ... Cantley LC, et al. Abstract 4979: Cabozantinib eradicates advanced murine prostate cancer by activating neutrophil-mediated anti-tumor innate immunity Cancer Research. 76: 4979-4979. DOI: 10.1158/1538-7445.Am2016-4979  0.371
2016 Stahlhut CE, Ambrico AJ, Watrud KE, Cho H, Wang L, Qi J, Cantley LC, Bradner J, Trotman L. Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer Cancer Research. 76: 4165-4165. DOI: 10.1158/1538-7445.Am2016-4165  0.327
2016 Liu H, Murphy C, Karreth F, Yang K, Wulf G, Cantley LC. Abstract 3858: Feasibility and efficacy of a precision treatment approach for triple-negative breast cancer in mouse models Cancer Research. 76: 3858-3858. DOI: 10.1158/1538-7445.Am2016-3858  0.35
2016 Nabavi S, Juvekar A, Wang N, Cantley LC, Wulf GM. Abstract 159: Analysis of resistance to the combination of a PI3K- and Parp-inhibitor using a genomic sequencing approach Cancer Research. 76: 159-159. DOI: 10.1158/1538-7445.Am2016-159  0.322
2016 Taniguchi C, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley L, Kahn C. Divergent Regulation of Hepatic Glucose and Lipid Metabolism by Phosphoinositide 3-Kinase via Akt and PKCλ/ζ Cell Metabolism. 23: 386. DOI: 10.1016/J.Cmet.2016.01.016  0.589
2015 DeNicola GM, Cantley LC. Cancer's Fuel Choice: New Flavors for a Picky Eater. Molecular Cell. 60: 514-23. PMID 26590711 DOI: 10.1016/J.Molcel.2015.10.018  0.668
2015 Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC. EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nature Structural & Molecular Biology. PMID 26551075 DOI: 10.1038/Nsmb.3117  0.372
2015 Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, ... ... Cantley LC, et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (New York, N.Y.). PMID 26541605 DOI: 10.1126/Science.Aaa5004  0.686
2015 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. PMID 26482881 DOI: 10.1038/Ng.3421  0.705
2015 Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP, Cantley LC, DeBerardinis RJ, Kimmelman AC, Lyssiotis CA, Boothman DA. Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. Cancer & Metabolism. 3: 12. PMID 26462257 DOI: 10.1186/S40170-015-0137-1  0.619
2015 Sadanandam A, Wullschleger S, Lyssiotis CA, Grotzinger C, Barbi S, Bersani S, Korner J, Wafy I, Mafficini A, Lawlor RT, Simbolo M, Asara JM, Blaker H, Cantley LC, Wiedenmann B, et al. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics. Cancer Discovery. PMID 26446169 DOI: 10.1158/2159-8290.Cd-15-0068  0.685
2015 Kim JA, Im S, Cantley LC, Kim DW. Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy. Cellular Signalling. PMID 26363466 DOI: 10.1016/J.Cellsig.2015.09.004  0.383
2015 Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.Cd-15-0460  0.639
2015 Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E. Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochimica Et Biophysica Acta. 1852: 2056-65. PMID 26170063 DOI: 10.1016/J.Bbadis.2015.07.009  0.56
2015 Dibble CC, Cantley LC. Regulation of mTORC1 by PI3K signaling. Trends in Cell Biology. 25: 545-55. PMID 26159692 DOI: 10.1016/J.Tcb.2015.06.002  0.779
2015 Westin SN, Ju Z, Broaddus RR, Krakstad C, Li J, Pal N, Lu KH, Coleman RL, Hennessy BT, Klempner SJ, Werner HM, Salvesen HB, Cantley LC, Mills GB, Myers AP. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients. Molecular Oncology. PMID 26045339 DOI: 10.1016/J.Molonc.2015.04.014  0.346
2015 Ehrenberger T, Cantley LC, Yaffe MB. Computational prediction of protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 1278: 57-75. PMID 25859943 DOI: 10.1007/978-1-4939-2425-7_4  0.494
2015 Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, ... ... Cantley LC, et al. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nature Medicine. 21: 457-66. PMID 25849135 DOI: 10.1038/Nm.3839  0.411
2015 Chen J, Lee HJ, Wu X, Huo L, Kim SJ, Xu L, Wang Y, He J, Bollu LR, Gao G, Su F, Briggs J, Liu X, Melman T, Asara JM, ... ... Cantley LC, et al. Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. Cancer Research. 75: 554-65. PMID 25511375 DOI: 10.1158/0008-5472.Can-14-2268  0.579
2015 Wulf GM, Juvekar A, Lyssiotis CM, Hu H, Baek K, Yadegarynia S, Scully R, Winer E, Asara J, Cantley LC, Matulonis U. Abstract IA21: Combination treatments that include PI3K-inhibitors for the treatment of triple-negative breast cancer Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-Ia21  0.363
2015 Cantley LC. Abstract IA01: Targeting phosphoinositide 3-kinase for cancer therapy Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-Ia01  0.448
2015 Wang LC, Kim SS, Nanus DM, Cantley LC. Abstract A33: Utilizing insulin the treatment of prostate cancer with BKM120 abrogates the therapeutic effect of PI3K pathway inhibition Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-A33  0.385
2015 Viale A, Pettazzoni P, Lyssiotis C, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Heffernan T, Kimmelman A, Wang H, Fleming J, Cantley L, et al. Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-Pr13  0.621
2015 Lyssiotis CA, Son J, Mancias JD, Ying H, Cantley LC, Kimmelman AC. Abstract B45: Pancreatic cancers depend on a non-canonical glutamine metabolism pathway Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-B45  0.396
2015 Shen C, Yuan P, Perez-Lorenzo R, Zhang Y, Lee SX, Ou Y, Cai L, Asara JM, Cantley LC, Zheng B. Abstract B09: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation Cancer Research. 75. DOI: 10.1158/1538-7445.Mel2014-B09  0.437
2015 Patnaik A, Swanson K, Helenius K, Thomas T, Pyzer A, Csizmadia V, Signoretti S, Morgan T, Wang Y, Elemento O, Wang L, Levantini E, Clohessy J, Asara J, Smith D, ... ... Cantley L, et al. Abstract 5497: Cabozantinib eradicatesde novocastrate-resistant PTEN/p53 deficient murine prostate cancer via activation of neutrophil-mediated anti-tumor innate immunity Cancer Research. 75: 5497-5497. DOI: 10.1158/1538-7445.Am2015-5497  0.35
2015 Emerling BM, Yang Z, Loughran R, Yang TJ, Johnson J, Pragani R, Davis M, Shen M, Boxer M, Simeonov A, Cantley LC. Abstract 4714: Targeting p53 mutant cancers through inhibition of the phosphatidylinositol-5-phosphate 4-kinases Cancer Research. 75: 4714-4714. DOI: 10.1158/1538-7445.Am2015-4714  0.441
2015 Juvekar AP, Yadegarynia S, Hu H, Lyssiotis CA, Liu H, Asara JM, Scully R, Cantley LC, Wulf GM. Abstract 2650: PI 3-Kinase inhibitors enhance the synthetic lethality of Parp inhibitors Cancer Research. 75: 2650-2650. DOI: 10.1158/1538-7445.Am2015-2650  0.412
2015 Stahlhut CE, Watrud KE, Ambrico AJ, Cho H, Wang L, Qi J, Cantley LC, Bradner J, Trotman LC. Abstract 2636: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer Cancer Research. 75: 2636-2636. DOI: 10.1158/1538-7445.Am2015-2636  0.32
2015 Nabavi S, Holton KM, Juvekar A, Wang N, Elemento O, Cantley LC, Wulf GM. Abstract 1081: Non-random genomic alterations in BRCA1-related breast cancer Cancer Research. 75: 1081-1081. DOI: 10.1158/1538-7445.Am2015-1081  0.324
2015 Patnaik A, Swanson K, Signoretti S, Ye H, Csizmadia E, Novak J, Gehring M, Helenius K, Pyzer A, Montaser L, Wang L, Elemento O, Levantini E, Clohessy J, Asara J, ... ... Cantley L, et al. Abstract C112: Cabozantinib eradicates advanced murine prostate cancer by activating anti-tumor innate immunity Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C112  0.369
2015 Courtney KD, Cantley LC. PI3K Molecular Oncology: Causes of Cancer and Targets For Treatment. 218-230. DOI: 10.1017/CBO9781139046947.019  0.301
2015 Dibble CC, Cantley LC. Regulation of mTORC1 by PI3K signaling Trends in Cell Biology. DOI: 10.1016/j.tcb.2015.06.002  0.729
2015 Wang L, Nanus D, Cantley L. MP46-10 UTILIZING INSULIN IN THE TREATMENT OF PROSTATE CANCER WITH BKM120 ABROGATES THE THERAPEUTIC EFFECT OF PI3K PATHWAY INHIBITION Journal of Urology. 193. DOI: 10.1016/J.Juro.2015.02.1573  0.313
2015 Yang T, Wang D, Pauli C, Loughran R, Kim H, Zhang T, Annamalai D, Emerling B, Powell S, Gray N, Cantley L. Inhibition of Phosphatidylinositol-5-Phosphate 4-Kinases (PI5P4Kα and β) Inhibits Proliferation and Radiosensitizes Triple Negative Breast Cancer Cells Harboring p53 Mutations International Journal of Radiation Oncology*Biology*Physics. 93: S49-S50. DOI: 10.1016/J.Ijrobp.2015.07.120  0.374
2014 Lyssiotis CA, Cantley LC. Acetate fuels the cancer engine. Cell. 159: 1492-4. PMID 25525870 DOI: 10.1016/J.Cell.2014.12.009  0.579
2014 Thorner J, Hunter T, Cantley LC, Sever R. Signal transduction: From the atomic age to the post-genomic era. Cold Spring Harbor Perspectives in Biology. 6: a022913. PMID 25359498 DOI: 10.1101/Cshperspect.A022913  0.301
2014 Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 158: 1309-23. PMID 25215489 DOI: 10.1016/J.Cell.2014.07.048  0.599
2014 Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, ... ... Cantley LC, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 514: 628-32. PMID 25119024 DOI: 10.1038/Nature13611  0.626
2014 González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, ... ... Cantley LC, et al. Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. Cancer Discovery. 4: 896-904. PMID 24866151 DOI: 10.1158/2159-8290.Cd-13-0230  0.317
2014 Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U. BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metabolism. 20: 73-84. PMID 24836559 DOI: 10.1016/J.Cmet.2014.04.006  0.349
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Cantley L, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/Nature13079  0.758
2014 Mayer IA, Abramson VG, Isakoff SJ, Forero A, Balko JM, Kuba MG, Sanders ME, Yap JT, Van den Abbeele AD, Li Y, Cantley LC, Winer E, Arteaga CL. Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 1202-9. PMID 24663045 DOI: 10.1200/Jco.2013.54.0518  0.34
2014 Chiu YH, Lee JY, Cantley LC. BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity. Molecular Cell. 54: 193-202. PMID 24657164 DOI: 10.1016/J.Molcel.2014.02.016  0.365
2014 Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J. A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. The Journal of Biological Chemistry. 289: 13010-25. PMID 24634222 DOI: 10.1074/Jbc.M113.546515  0.662
2014 Fruman DA, Cantley LC. Idelalisib--a PI3Kδ inhibitor for B-cell cancers. The New England Journal of Medicine. 370: 1061-2. PMID 24620870 DOI: 10.1056/Nejme1400055  0.427
2014 Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 156: 771-85. PMID 24529379 DOI: 10.1016/J.Cell.2013.11.049  0.763
2014 Cantley LC. Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar. Bmc Biology. 12: 8. PMID 24484968 DOI: 10.1186/1741-7007-12-8  0.339
2014 Cheng H, Liu P, Zhang F, Xu E, Symonds L, Ohlson CE, Bronson RT, Maira SM, Di Tomaso E, Li J, Myers AP, Cantley LC, Mills GB, Zhao JJ. A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Cancer Research. 74: 15-23. PMID 24322983 DOI: 10.1158/0008-5472.Can-13-0544  0.396
2014 Lyssiotis CA, Cantley LC. Targeting metabolic scavenging in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6-8. PMID 24166909 DOI: 10.1158/1078-0432.Ccr-13-2570  0.627
2014 Matulonis U, Wulf GM, Birrer MJ, Westin SN, Quy P, Bell-McGuinn KM, Lasonde B, Whalen C, Aghajanian C, Solit DB, Mills GB, Cantley L, Winer EP. Phase I study of oral BKM120 and oral olaparib for high-grade serous ovarian cancer (HGSC) or triple-negative breast cancer (TNBC). Journal of Clinical Oncology. 32: 2510-2510. DOI: 10.1200/Jco.2014.32.15_Suppl.2510  0.34
2014 Lyssiotis C, Son J, Mancias J, Ying H, Kimmelman A, Cantley L. Pancreatic cancers depend on a non-canonical glutamine metabolism pathway Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P44  0.635
2014 Cantley LC. Maintenance of Pluripotent Stem Cells is Influenced by Ser/Thr Metabolism Blood. 124: SCI-43-SCI-43. DOI: 10.1182/Blood.V124.21.Sci-43.Sci-43  0.334
2014 Emerling BM, Hurov JB, Poulogiannis G, Choo-Wing R, Wulf GM, Shim H, Lamia KA, Rameh LE, Yuan X, Bullock A, DeNicola GM, Song J, Signoretti S, Cantley LC. Abstract NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Ng05  0.801
2014 Patnaik A, Loda M, Kung J, Wu J, Taplin M, Kantoff P, Cantley L, Balk S, Bubley G. Abstract CT418: A Phase Ib study of BKM120 combined with abiraterone acetate for castrate-resistant, metastatic prostate cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Ct418  0.319
2014 Wulf GM, Juvekar A, Lyssiotis CA, Hu H, Yadegarynia S, Liu H, Kim B, Winter E, Scully R, Asara J, Cantley LC, Matulonis U. Abstract CT338: Combination of a PI3K- and a PARP-inhibitor to treat high-grade serous ovarian or triple-negative breast cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Ct338  0.407
2014 Yun J, Kavalier A, Mullarky E, Bosch K, Roper J, Rago C, Paik J, Asara J, Gross S, Vogelstein B, Papadopoulos N, Cantley L. Abstract 2951: Vitamin C is selectively toxic to cancer cells harboring KRAS or BRAF mutations by targeting GAPDH Cancer Research. 74: 2951-2951. DOI: 10.1158/1538-7445.Am2014-2951  0.739
2014 Sumita K, Davis M, Pragani R, Terakawa J, Daikoku T, Majd N, Shen M, Li Z, Hu X, Cantley L, Boxer M, Simeonov A, Sasaki A. CS-33 * DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME Neuro-Oncology. 16: v58-v58. DOI: 10.1093/Neuonc/Nou242.33  0.437
2014 Park S, Herrema H, Salazar M, Cakir I, Cabi S, Sahin F, Chiu Y, Cantley L, Ozcan U. BRD7 Regulates XBP1s’ Activity and Glucose Homeostasis through Its Interaction with the Regulatory Subunits of PI3K Cell Metabolism. 20: 1088. DOI: 10.1016/J.Cmet.2014.11.009  0.316
2013 Klempner SJ, Myers AP, Cantley LC. What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. Cancer Discovery. 3: 1345-54. PMID 24265156 DOI: 10.1158/2159-8290.Cd-13-0063  0.401
2013 Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, ... ... Cantley LC, et al. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 155: 844-57. PMID 24209622 DOI: 10.1016/J.Cell.2013.09.057  0.818
2013 Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B. Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 110: 18226-31. PMID 24145418 DOI: 10.1073/Pnas.1317577110  0.395
2013 Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, ... ... Cantley LC, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/J.Cell.2013.09.025  0.607
2013 Lyssiotis CA, Cantley LC. Metabolic syndrome: F stands for fructose and fat. Nature. 502: 181-2. PMID 24108049 DOI: 10.1038/502181A  0.576
2013 Shen CH, Yuan P, Perez-Lorenzo R, Zhang Y, Lee SX, Ou Y, Asara JM, Cantley LC, Zheng B. Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. Molecular Cell. 52: 161-72. PMID 24095280 DOI: 10.1016/J.Molcel.2013.08.044  0.427
2013 Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik JH. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. The Embo Journal. 32: 2589-602. PMID 24013118 DOI: 10.1038/Emboj.2013.186  0.609
2013 Lyssiotis CA, Son J, Cantley LC, Kimmelman AC. Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance. Cell Cycle (Georgetown, Tex.). 12: 1987-8. PMID 23759579 DOI: 10.4161/Cc.25307  0.611
2013 Chen S, Jiang X, Gewinner CA, Asara JM, Simon NI, Cai C, Cantley LC, Balk SP. Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases. Science Signaling. 6: ra40. PMID 23716717 DOI: 10.1126/Scisignal.2003936  0.402
2013 Shyh-Chang N, Daley GQ, Cantley LC. Stem cell metabolism in tissue development and aging. Development (Cambridge, England). 140: 2535-47. PMID 23715547 DOI: 10.1242/Dev.091777  0.344
2013 Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, ... ... Cantley LC, et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discovery. 3: 870-9. PMID 23715154 DOI: 10.1158/2159-8290.Cd-13-0015  0.405
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.Can-13-0080  0.589
2013 Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells (Dayton, Ohio). 31: 1563-73. PMID 23666760 DOI: 10.1002/Stem.1423  0.336
2013 Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/J.Cell.2013.04.023  0.439
2013 Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, ... Cantley LC, et al. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of Biological Chemistry. 288: 17360-71. PMID 23640882 DOI: 10.1074/Jbc.M112.441469  0.646
2013 Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nature Biotechnology. 31: 522-9. PMID 23604282 DOI: 10.1038/Nbt.2530  0.679
2013 Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LC, Lannon WA, Grotzinger C, Del Rio M, Lhermitte B, Olshen AB, Wiedenmann B, Cantley LC, Gray JW, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine. 19: 619-25. PMID 23584089 DOI: 10.1038/Nm.3175  0.691
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, ... ... Cantley LC, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/Nature12040  0.646
2013 Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Molecular Cell. 49: 1167-75. PMID 23453806 DOI: 10.1016/J.Molcel.2013.01.035  0.321
2013 Carracedo A, Cantley LC, Pandolfi PP. Cancer metabolism: fatty acid oxidation in the limelight. Nature Reviews. Cancer. 13: 227-32. PMID 23446547 DOI: 10.1038/Nrc3483  0.383
2013 Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC. Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proceedings of the National Academy of Sciences of the United States of America. 110: 3483-8. PMID 23378636 DOI: 10.1073/Pnas.1222435110  0.671
2013 Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A. A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. Plos One. 8: e54127. PMID 23326584 DOI: 10.1371/Journal.Pone.0054127  0.35
2013 Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL. Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nature Structural & Molecular Biology. 20: 46-52. PMID 23178454 DOI: 10.1038/Nsmb.2430  0.543
2013 Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular Cell. 49: 172-85. PMID 23142078 DOI: 10.1016/J.Molcel.2012.10.003  0.368
2013 Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (New York, N.Y.). 339: 222-6. PMID 23118012 DOI: 10.1126/Science.1226603  0.691
2013 Myers AP, Broaddus R, Makker V, Konstantinopoulos PA, Drapkin R, Horowitz NS, Liu J, Hummelen PV, Meric-Bernstam F, Birrer MJ, Doyle LA, Coleman RL, Aghajanian C, Mills GB, Cantley L, et al. Phase II, two-stage, two-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer (EC). Journal of Clinical Oncology. 31: 5524-5524. DOI: 10.1200/Jco.2013.31.15_Suppl.5524  0.301
2013 Ju Z, Westin SN, Broaddus R, Li J, Pal N, Lu KH, Coleman RL, Klempner S, Cantley L, Mills GB, Myers AP. PTEN loss as a context-dependent determinant of patient outcomes in obese and non-obese endometrioid endometrial cancer patients. Journal of Clinical Oncology. 31: 5521-5521. DOI: 10.1200/Jco.2013.31.15_Suppl.5521  0.323
2013 Wang Y, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT. Differential Dependence On Aerobic Glycolysis In Normal and Malignant Hematopoietic Stem and Progenitor Cells To Sustain Daughter Cell Production Blood. 122: 793-793. DOI: 10.1182/Blood.V122.21.793.793  0.371
2013 Cantley LC. Abstract IA22: PI3K and cancer metabolism Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia22  0.445
2013 Yun J, Kavalier A, Roper J, Gross S, Rago C, Papadopoulos N, Vogelstein B, Cantley L. Abstract C60: Vitamin C inhibits the survival and growth of colorectal cancer cells with KRAS or BRAF mutations Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C60  0.733
2013 Emerling BM, Benes C, Bell E, Poulogiannis G, Courtney K, Lui H, Choo-Wing R, Bellinger G, Soltoff S, Cantley L. Abstract 4588: Identification of CDCP1 as a HIF-2α target gene involved in the regulation of cancer cell migration and metastasis. Cancer Research. 73: 4588-4588. DOI: 10.1158/1538-7445.Am2013-4588  0.677
2013 Klempner SJ, Myers AP, Li J, Mills G, Cantley LC. Abstract 4265: Derivation and characterization of endometrial cancer cells resistant to phosphatidylinositol-3-kinase (PI3K) pathway inhibitors. Cancer Research. 73: 4265-4265. DOI: 10.1158/1538-7445.Am2013-4265  0.423
2013 Matulonis U, Wulf G, Cantley L, Mills G, Lasonde B, Atkinson T, Whalen C, Isakoff S, Westin S, Bell-McGuinn K, Winer E. Abstract OT1-4-02: Phase I study of the combination of BKM120 and olaparib for the treatment of high grade serous ovarian cancer (HGSC) and triple negative breast cancer (TNBC) Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-Ot1-4-02  0.37
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, ... ... Cantley LC, et al. Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature. 499: 504-504. DOI: 10.1038/Nature12317  0.628
2012 Lyssiotis CA, Cantley LC. SIRT6 puts cancer metabolism in the driver's seat. Cell. 151: 1155-6. PMID 23217699 DOI: 10.1016/J.Cell.2012.11.020  0.643
2012 Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology. 14: 1295-304. PMID 23178880 DOI: 10.1038/Ncb2629  0.639
2012 Quayle SN, Lee JY, Cheung LW, Ding L, Wiedemeyer R, Dewan RW, Huang-Hobbs E, Zhuang L, Wilson RK, Ligon KL, Mills GB, Cantley LC, Chin L. Somatic mutations of PIK3R1 promote gliomagenesis. Plos One. 7: e49466. PMID 23166678 DOI: 10.1371/Journal.Pone.0049466  0.384
2012 Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P, Morissette MR, del Monte F, Begley MJ, Cantley LC, Ellinor PT, et al. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation. 126: 2208-19. PMID 23019294 DOI: 10.1161/Circulationaha.112.115592  0.323
2012 Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, ... ... Cantley LC, et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chemistry & Biology. 19: 1187-98. PMID 22999886 DOI: 10.1016/J.Chembiol.2012.07.021  0.63
2012 Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS. AACR Cancer Progress Report 2012. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: S1-100. PMID 22977188 DOI: 10.1158/1078-0432.Ccr-12-2891  0.302
2012 Myers AP, Cantley LC. Sugar free, cancer free? Nutrition (Burbank, Los Angeles County, Calif.). 28: 1036. PMID 22925542 DOI: 10.1016/J.Nut.2012.07.004  0.326
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Cantley LC, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/Nchembio.1060  0.767
2012 Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, ... Cantley LC, et al. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discovery. 2: 1048-63. PMID 22915751 DOI: 10.1158/2159-8290.Cd-11-0336  0.636
2012 Hutti JE, Porter MA, Cheely AW, Cantley LC, Wang X, Kireev D, Baldwin AS, Janzen WP. Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε. Plos One. 7: e41494. PMID 22859992 DOI: 10.1371/Journal.Pone.0041494  0.339
2012 Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB. p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metabolism. 16: 104-12. PMID 22727014 DOI: 10.1016/J.Cmet.2012.05.010  0.408
2012 Shaw RJ, Cantley LC. Cell biology. Ancient sensor for ancient drug. Science (New York, N.Y.). 336: 813-4. PMID 22605741 DOI: 10.1126/Science.1223140  0.348
2012 Marinis JM, Hutti JE, Homer CR, Cobb BA, Cantley LC, McDonald C, Abbott DW. IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling. Molecular and Cellular Biology. 32: 2479-89. PMID 22547678 DOI: 10.1128/Mcb.00106-12  0.362
2012 Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, ... ... Cantley LC, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/J.Cell.2012.01.058  0.717
2012 Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, ... ... Cantley LC, et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 483: 613-7. PMID 22425996 DOI: 10.1038/Nature10937  0.303
2012 Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 149: 49-62. PMID 22401813 DOI: 10.1016/J.Cell.2012.02.030  0.62
2012 Comb WC, Hutti JE, Cogswell P, Cantley LC, Baldwin AS. p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Molecular Cell. 45: 719-30. PMID 22342344 DOI: 10.1016/J.Molcel.2012.01.010  0.432
2012 Shaw RJ, Cantley LC. Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biology Reports. 4: 2. PMID 22242042 DOI: 10.3410/B4-2  0.406
2012 Locasale JW, Melman T, Song S, Yang X, Swanson KD, Cantley LC, Wong ET, Asara JM. Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. Molecular & Cellular Proteomics : McP. 11: M111.014688. PMID 22240505 DOI: 10.1074/Mcp.M111.014688  0.538
2012 Anastasiou D, Cantley LC. Breathless cancer cells get fat on glutamine. Cell Research. 22: 443-6. PMID 22212478 DOI: 10.1038/Cr.2012.5  0.388
2012 Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR. Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology. 4: 79-87. PMID 22044881 DOI: 10.1093/Jmcb/Mjr030  0.582
2012 Benes CH, Poulogiannis G, Cantley LC, Soltoff SP. The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Oncogene. 31: 653-63. PMID 21725358 DOI: 10.1038/Onc.2011.262  0.407
2012 Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP. Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. Journal of Cellular Physiology. 227: 1709-20. PMID 21688263 DOI: 10.1002/Jcp.22895  0.448
2012 Cantley LC. PI 3-kinase and disease Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O2  0.481
2012 Locasale JW, Grassian A, Beroukhim R, Meyerson M, Wagner G, Asara JM, Brugge JS, Vander Heiden MG, Cantley LC. Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O15  0.723
2012 Cantley LC. Abstract OP-03: PI 3-Kinase, AMPK, and Cancer Cancer Prevention Research. 5: OP-03-OP-03. DOI: 10.1158/1940-6207.Prev-12-Op-03  0.497
2012 Son J, Lyssiotis CA, Yang S, Ying H, Wang X, Cantley LC, Kimmelman AC. Abstract IA14: Autophagy, metabolism, and pancreatic cancer. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-Ia14  0.405
2012 Lyssiotis C, Ying H, Kimmelman A, DePinho R, Cantley L. Abstract A51: Oncogenic Kras is required for pancreatic tumor maintenance through the regulation of anabolic glucose metabolism. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A51  0.632
2012 Ying H, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik J, Lim C, Guimaraes AR, Kimmelman AC, Martin ES, Chang J, Hezel A, ... ... Cantley LC, et al. Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A101  0.609
2012 Patnaik A, Courtney K, Robichaud K, Bellinger G, Nardella C, Signoretti S, Wooster R, Pandolfi PP, Cantley L. Abstract LB-365: Effective use of PI3K/MTOR and MEK inhibitors prior to hormone ablative therapy in PTEN-loss driven murine prostate cancer Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-365  0.637
2012 Patnaik A, Wcislak SM, Cantley LC, Doll JA. Abstract LB-161: Metformin increases lipolytic metabolism and PEDF expression in prostate cancer cells Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-161  0.365
2012 Cantley L, Lewis CC. Abstract MS1-1: Targeting PI3K Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-Ms1-1  0.433
2012 Cantley L. PI 3-Kinase and Cancer Metabolism Annals of Oncology. 23: ix21. DOI: 10.1093/Annonc/Mds366  0.473
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang J, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Cantley LC, et al. Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Nature Chemical Biology. 8: 1008-1008. DOI: 10.1038/Nchembio1212-1008B  0.64
2012 Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. Erratum: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect Nature Cell Biology. 15: 124-124. DOI: 10.1038/Ncb2677  0.601
2012 Lyssiotis CA, Anastasiou D, Locasale JW, Vander Heiden MG, Christofk HR, Cantley LC. Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth Biomedical Research. 23: 213-217.  0.554
2011 Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biology. 1: 110012. PMID 22645651 DOI: 10.1098/Rsob.110012  0.382
2011 Cantley LC, Baselga J. The era of cancer discovery. Cancer Discovery. 1: 1. PMID 22586302 DOI: 10.1158/2159-8274.Cd-11-0049  0.341
2011 Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Metabolic pathway alterations that support cell proliferation. Cold Spring Harbor Symposia On Quantitative Biology. 76: 325-34. PMID 22262476 DOI: 10.1101/Sqb.2012.76.010900  0.736
2011 Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC. Human pluripotent stem cells decouple respiration from energy production. The Embo Journal. 30: 4851-2. PMID 22166995 DOI: 10.1038/Emboj.2011.436  0.563
2011 Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, ... ... Cantley LC, et al. Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discovery. 1: 35-43. PMID 22140652 DOI: 10.1158/2159-8274.Cd-10-0022  0.368
2011 Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell. 44: 878-92. PMID 22137581 DOI: 10.1016/J.Molcel.2011.11.005  0.726
2011 Locasale JW, Cantley LC. Genetic selection for enhanced serine metabolism in cancer development. Cell Cycle (Georgetown, Tex.). 10: 3812-3. PMID 22064516 DOI: 10.4161/Cc.10.22.18224  0.575
2011 Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (New York, N.Y.). 334: 1278-83. PMID 22052977 DOI: 10.1126/Science.1211485  0.708
2011 Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/J.Molcel.2011.08.030  0.797
2011 Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J, Wong KK, Cantley LC, Engelman JA. Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. The Journal of Clinical Investigation. 121: 4311-21. PMID 21985784 DOI: 10.1172/Jci57909  0.432
2011 Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, Ju Z, Cantley LC, Scherer SE, Liang H, Lu KH, et al. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discovery. 1: 170-85. PMID 21984976 DOI: 10.1158/2159-8290.Cd-11-0039  0.391
2011 Locasale JW, Cantley LC. Metabolic flux and the regulation of mammalian cell growth. Cell Metabolism. 14: 443-51. PMID 21982705 DOI: 10.1016/J.Cmet.2011.07.014  0.595
2011 Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell & Melanoma Research. 24: 1112-5. PMID 21981974 DOI: 10.1111/J.1755-148X.2011.00919.X  0.713
2011 Walsh MJ, Brimacombe KR, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas CJ, Boxer MB. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 21: 6322-7. PMID 21958545 DOI: 10.1016/J.Bmcl.2011.08.114  0.626
2011 Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 146: 607-20. PMID 21854985 DOI: 10.1016/J.Cell.2011.06.050  0.663
2011 Lee JY, Chiu YH, Asara J, Cantley LC. Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains. Proceedings of the National Academy of Sciences of the United States of America. 108: 14157-62. PMID 21825134 DOI: 10.1073/Pnas.1107747108  0.419
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, ... ... Cantley LC, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/Ng.890  0.782
2011 Yang X, Turke AB, Qi J, Song Y, Rexer BN, Miller TW, Jänne PA, Arteaga CL, Cantley LC, Engelman JA, Asara JM. Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer. Cancer Research. 71: 5965-75. PMID 21775521 DOI: 10.1158/0008-5472.Can-11-0445  0.427
2011 Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (New York, N.Y.). 332: 1322-6. PMID 21659605 DOI: 10.1126/Science.1199484  0.44
2011 Bouskila M, Esoof N, Gay L, Fang EH, Deak M, Begley MJ, Cantley LC, Prescott A, Storey KG, Alessi DR. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. The Biochemical Journal. 437: 157-67. PMID 21548880 DOI: 10.1042/Bj20110276  0.374
2011 Saci A, Cantley LC, Carpenter CL. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Molecular Cell. 42: 50-61. PMID 21474067 DOI: 10.1016/J.Molcel.2011.03.017  0.384
2011 Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC. A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metabolism. 13: 476-86. PMID 21459332 DOI: 10.1016/J.Cmet.2011.03.006  0.598
2011 Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC. Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Science Signaling. 4: ra13. PMID 21386094 DOI: 10.1126/Scisignal.2001518  0.549
2011 Yuan TL, Wulf G, Burga L, Cantley LC. Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Current Biology : Cb. 21: 173-83. PMID 21256021 DOI: 10.1016/J.Cub.2010.12.047  0.707
2011 Cantley LC. Abstract SY34-01: Biomarkers for predicting response to PI3K inhibitors Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy34-01  0.476
2011 Patnaik A, Courtney K, Bellinger G, Lunsford E, Robichaud K, Grant A, Lenkinski R, Pedrosa I, Signoretti S, Wooster R, Cantley L. Abstract LB-418: Targeting the PI3K/mTOR pathway in genetically engineered mouse models of prostate cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-418  0.63
2011 Yang X, Locasale J, Rahal R, Breitkopf S, VanderHeiden M, Spentzos D, Wu C, Perrimon N, Cantley L, Wong E, Asara J. Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-255  0.628
2011 Cheung LWT, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Zhang F, Ju Z, Cantley LC, Scherer SE, Liang H, Lu KH, Russell BR, et al. Mutation and functional analysis of PIK3CA and PIK3R1 in endometrial cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-247  0.39
2011 Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J, Cantley LC, Wong K, Engelman JA. Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers Cancer Research. 71: 956-956. DOI: 10.1158/1538-7445.Am2011-956  0.439
2011 Asara JM, Cantley LC, Engelman JA. Abstract 5121: A targeted approach to identify activators of class IA phosphoinositide-3-kinase in cancers using tandem mass spectrometry Cancer Research. 71: 5121-5121. DOI: 10.1158/1538-7445.Am2011-5121  0.433
2011 Wang X, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Gopalan A, Reuter VE, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM. Abstract 2808: Characterization of KRAS rearrangements in metastatic prostate cancer Cancer Research. 71: 2808-2808. DOI: 10.1158/1538-7445.Am2011-2808  0.367
2010 Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, ... ... Cantley LC, et al. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metabolism. 12: 619-32. PMID 21109194 DOI: 10.1016/J.Cmet.2010.11.005  0.58
2010 Locasale JW, Vander Heiden MG, Cantley LC. Rewiring of glycolysis in cancer cell metabolism. Cell Cycle (Georgetown, Tex.). 9: 4253. PMID 21045562 DOI: 10.4161/Cc.9.21.13925  0.701
2010 Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (New York, N.Y.). 329: 1492-9. PMID 20847263 DOI: 10.1126/Science.1188015  0.747
2010 Myers AP, Cantley LC. Targeting a common collaborator in cancer development. Science Translational Medicine. 2: 48ps45. PMID 20826838 DOI: 10.1126/Scitranslmed.3001251  0.382
2010 Engelman JA, Cantley LC. Chemoprevention meets glucose control. Cancer Prevention Research (Philadelphia, Pa.). 3: 1049-52. PMID 20810671 DOI: 10.1158/1940-6207.Capr-10-0178  0.316
2010 Baba Y, Nosho K, Shima K, Meyerhardt JA, Chan AT, Engelman JA, Cantley LC, Loda M, Giovannucci E, Fuchs CS, Ogino S. Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. British Journal of Cancer. 103: 1025-33. PMID 20808308 DOI: 10.1038/Sj.Bjc.6605846  0.408
2010 Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, et al. Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Science Signaling. 3: ra64. PMID 20736484 DOI: 10.1126/Scisignal.2000998  0.438
2010 Locasale JW, Cantley LC. Altered metabolism in cancer. Bmc Biology. 8: 88. PMID 20598111 DOI: 10.1186/1741-7007-8-88  0.601
2010 Yuan TL, Cantley LC. Introduction. Current Topics in Microbiology and Immunology. 346: 1-7. PMID 20582535 DOI: 10.1007/82_2010_55  0.669
2010 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Cantley LC, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 465: 966. PMID 20559394 DOI: 10.1038/nature09132  0.571
2010 Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Research. 70: 5305-15. PMID 20530665 DOI: 10.1158/0008-5472.Can-09-3399  0.592
2010 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular Cell. 38: 487-99. PMID 20513425 DOI: 10.1016/J.Molcel.2010.05.007  0.704
2010 Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, et al. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One. 5: e10504. PMID 20498699 DOI: 10.1371/Journal.Pone.0010504  0.606
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/J.Bmcl.2010.04.015  0.718
2010 Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 1894-9. PMID 20133837 DOI: 10.1073/Pnas.0914845107  0.797
2010 Takeuchi H, Takeuchi T, Gao J, Cantley LC, Hirata M. Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Molecular and Cellular Biology. 30: 1689-702. PMID 20086096 DOI: 10.1128/Mcb.01105-09  0.307
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/Jm901577G  0.704
2010 Wong KK, Engelman JA, Cantley LC. Targeting the PI3K signaling pathway in cancer. Current Opinion in Genetics & Development. 20: 87-90. PMID 20006486 DOI: 10.1016/J.Gde.2009.11.002  0.393
2010 Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 79: 1118-24. PMID 20005212 DOI: 10.1016/J.Bcp.2009.12.003  0.737
2010 Shiga K, Takayama K, Futaki S, Hutti JE, Cantley LC, Ueki K, Ono Y, Mukai H. Development of an intracellularly acting inhibitory peptide selective for PKN. The Biochemical Journal. 425: 445-53. PMID 19857203 DOI: 10.1042/Bj20090380  0.317
2010 Asara JM, Locasale J, Yang X, Rahal R, Perrimon N, Cantley LC, Wong ET, Heiden MGV. A mass spectrometry platform to quantitatively profile cancer cell metabolism from cell lines to tissues F1000research. 1. DOI: 10.7490/F1000Research.413.1  0.578
2010 Hitosugi T, Kang S, Vander Heiden M, Chung T, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen G, Xie J, Gu T, Polakiewicz R, Roesel JL, Boggon T, ... ... Cantley L, et al. Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth Blood. 116: 3142-3142. DOI: 10.1182/Blood.V116.21.3142.3142  0.497
2010 Hitosugi T, Kang S, Heiden MGV, Chung T, Lonial S, Wang X, Chen GZ, Xie J, Gu T, Polakiewicz RD, Roesel JL, Boggon T, Khuri F, Gilliland DG, Cantley LC, et al. Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth Cancer Research. 70: 34-34. DOI: 10.1158/1538-7445.Am10-34  0.486
2010 Fantin VR, Dang L, White DW, Gross S, Bittinger MA, Driggers EM, Jang HG, Jin S, Keenan MC, Marks KM, Yen KE, Ward PS, Prins RM, Liau LM, Bennett BD, ... ... Cantley LC, et al. Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Cancer Research. 70: 33-33. DOI: 10.1158/1538-7445.Am10-33  0.479
2009 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Cantley LC, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462: 739-44. PMID 19935646 DOI: 10.1038/Nature08617  0.703
2009 Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, ... ... Cantley LC, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Science Signaling. 2: ra73. PMID 19920251 DOI: 10.1126/Scisignal.2000431  0.739
2009 Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 150: 4874-82. PMID 19819947 DOI: 10.1210/En.2009-0454  0.557
2009 Locasale JW, Cantley LC, Vander Heiden MG. Cancer's insatiable appetite. Nature Biotechnology. 27: 916-7. PMID 19816448 DOI: 10.1038/Nbt1009-916  0.697
2009 Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. The Biochemical Journal. 424: 47-60. PMID 19740074 DOI: 10.1042/Bj20091035  0.381
2009 Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP. Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2670-9. PMID 19705443 DOI: 10.1002/Dvdy.22078  0.67
2009 Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell. 16: 115-25. PMID 19647222 DOI: 10.1016/J.Ccr.2009.06.006  0.409
2009 Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Molecular Cancer Therapeutics. 8: 1666-75. PMID 19509266 DOI: 10.1158/1535-7163.Mct-08-1012  0.492
2009 Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC. Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Molecular Cell. 34: 461-72. PMID 19481526 DOI: 10.1016/J.Molcel.2009.04.031  0.409
2009 Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (New York, N.Y.). 324: 1029-33. PMID 19460998 DOI: 10.1126/Science.1160809  0.691
2009 Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, et al. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (New York, N.Y.). 324: 626-31. PMID 19407199 DOI: 10.1126/Science.1165069  0.495
2009 Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer Journal of Clinical Oncology. 27: 1477-1484. PMID 19237633 DOI: 10.1200/Jco.2008.18.6544  0.303
2009 Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 136: 521-34. PMID 19203585 DOI: 10.1016/J.Cell.2008.11.044  0.338
2009 Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, Cantley LC. Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation Molecular Cell. 33: 237-247. PMID 19187764 DOI: 10.1016/J.Molcel.2008.12.026  0.426
2009 Cantley LC. Abstract IA-2: PI3‐Kinase and cancer metabolism Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-Ia-2  0.346
2009 Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (Proceedings of the National Academy of Sciences of the United States of America (2009) 103, 45, (16882-16887) 10.1073/pnas. 0607984103) Proceedings of the National Academy of Sciences of the United States of America. 106: 10871. DOI: 10.1073/Pnas.0905401106  0.536
2009 Nakamura M, Masuda H, Iwasawa M, Nagase Y, Nakamura T, Kato S, Ueki K, Luo J, Cantley L, Nakamura K, Tanaka S. Class IA phosphatidylinositol 3-kinases are indispensable for osteoclast function by regulating cytoskeletal organization and cell death Bone. 44: S49-S50. DOI: 10.1016/J.Bone.2009.01.127  0.57
2008 Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, ... ... Cantley LC, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature Medicine. 14: 1351-6. PMID 19029981 DOI: 10.1038/Nm.1890  0.405
2008 Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene. 27: 5497-510. PMID 18794884 DOI: 10.1038/Onc.2008.245  0.722
2008 Shaywitz AJ, Courtney KD, Patnaik A, Cantley LC. PI3K enters beta-testing. Cell Metabolism. 8: 179-81. PMID 18762017 DOI: 10.1016/J.Cmet.2008.08.011  0.664
2008 Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer Journal of Clinical Investigation. 118: 3065-3074. PMID 18725988 DOI: 10.1172/Jci34739  0.429
2008 Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L. Slow self-activation enhances the potency of viridin prodrugs. Journal of Medicinal Chemistry. 51: 4699-707. PMID 18630894 DOI: 10.1021/Jm800374F  0.367
2008 Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 9739-44. PMID 18621722 DOI: 10.1073/Pnas.0804123105  0.737
2008 Engelman JA, Cantley LC. A Sweet New Role for EGFR in Cancer Cancer Cell. 13: 375-376. PMID 18455118 DOI: 10.1016/J.Ccr.2008.04.008  0.405
2008 Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. The Journal of Clinical Investigation. 118: 1796-805. PMID 18382766 DOI: 10.1172/Jci32964  0.532
2008 Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452: 230-3. PMID 18337823 DOI: 10.1038/Nature06734  0.721
2008 Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein Nature. 452: 181-186. PMID 18337815 DOI: 10.1038/Nature06667  0.627
2007 Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW. IκB kinase β phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-κB pathway Molecular and Cellular Biology. 27: 7451-7461. PMID 17709380 DOI: 10.1128/Mcb.01101-07  0.613
2007 Lee JY, Engelman JA, Cantley LC. PI3K charges ahead Science. 317: 206-207. PMID 17626872 DOI: 10.1126/Science.1146073  0.342
2007 Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 129: 1261-74. PMID 17604717 DOI: 10.1016/J.Cell.2007.06.009  0.444
2007 Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC. Coordinated regulation of toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains Molecular and Cellular Biology. 27: 6012-6025. PMID 17562858 DOI: 10.1128/Mcb.00270-07  0.301
2007 Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 104: 8077-82. PMID 17483449 DOI: 10.1073/Pnas.0702663104  0.774
2007 Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, ... ... Cantley LC, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science (New York, N.Y.). 316: 1039-43. PMID 17463250 DOI: 10.1126/Science.1141478  0.346
2007 Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL. AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo Archives of Dermatology. 143: 504-506. PMID 17438183 DOI: 10.1001/Archderm.143.4.504  0.307
2007 Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 5680-5. PMID 17372192 DOI: 10.1073/Pnas.0701179104  0.333
2007 Holt LJ, Hutti JE, Cantley LC, Morgan DO. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Molecular Cell. 25: 689-702. PMID 17349956 DOI: 10.1016/J.Molcel.2007.02.012  0.377
2007 Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Molecular and Cellular Biology. 27: 2830-40. PMID 17283057 DOI: 10.1128/Mcb.00079-07  0.577
2007 Zheng B, Cantley LC. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase Proceedings of the National Academy of Sciences of the United States of America. 104: 819-822. PMID 17204563 DOI: 10.1073/Pnas.0610157104  0.389
2007 Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA. T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 109: 2894-902. PMID 17164340 DOI: 10.1182/Blood-2006-07-038620  0.562
2007 Engelman JA, Zejnullahu K, Mitsudomi T, Hyland C, Oh Park J, Lindeman N, Gale C, Zhao X, Christensen J, Rogers RM, Cappuzzo F, Mok T, Lee C, Bruce JE, Cantley LC, et al. D2-07: Mechanisms of activating PI3K signaling in lung cancers that become resistant EGFR tyrosine kinase inhibitors Journal of Thoracic Oncology. 2: S396. DOI: 10.1097/01.Jto.0000283263.45841.E0  0.361
2006 Turk BE, Hutti JE, Cantley LC. Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates Nature Protocols. 1: 375-379. PMID 17406259 DOI: 10.1038/Nprot.2006.57  0.607
2006 Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 103: 16882-7. PMID 17071741 DOI: 10.1073/Pnas.0607984103  0.546
2006 Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. The Journal of Clinical Investigation. 116: 2695-706. PMID 16906227 DOI: 10.1172/Jci28656  0.301
2006 Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proceedings of the National Academy of Sciences of the United States of America. 103: 12093-7. PMID 16880400 DOI: 10.1073/Pnas.0604628103  0.585
2006 Engelman JA, Cantley LC, Haber D, Settleman J, Bunn P, Johnson B, Heymach J, Goss G, Lynch T. The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors Clinical Cancer Research. 12: 4372s-4376s. PMID 16857813 DOI: 10.1158/1078-0432.Ccr-06-0795  0.388
2006 Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Reviews. Genetics. 7: 606-19. PMID 16847462 DOI: 10.1038/Nrg1879  0.614
2006 Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature. 441: 424-430. PMID 16724053 DOI: 10.1038/Nature04869  0.379
2006 Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC. Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metabolism. 3: 355-66. PMID 16679293 DOI: 10.1016/J.Cmet.2006.04.003  0.556
2006 Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metabolism. 3: 343-53. PMID 16679292 DOI: 10.1016/J.Cmet.2006.04.005  0.59
2006 Turk BE, Lee DH, Yamakoshi Y, Klingenhoff A, Reichenberger E, Wright JT, Simmer JP, Komisarof JA, Cantley LC, Bartlett JD. MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen Biochemistry. 45: 3863-3874. PMID 16548514 DOI: 10.1021/Bi052252O  0.549
2006 Pendaries C, Tronchère H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B. PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. The Embo Journal. 25: 1024-34. PMID 16482216 DOI: 10.1038/Sj.Emboj.7601001  0.406
2006 Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis Blood. 107: 3868-3875. PMID 16434494 DOI: 10.1182/Blood-2005-07-2755  0.309
2006 Yuan H, Luo J, Weissleder R, Cantley L, Josephson L. Wortmannin-C20 conjugates generate wortmannin. Journal of Medicinal Chemistry. 49: 740-7. PMID 16420059 DOI: 10.1021/Jm050699P  0.535
2006 Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/Journal.Pbio.0040038  0.509
2005 Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Research. 65: 10992-1000. PMID 16322248 DOI: 10.1158/0008-5472.Can-05-2612  0.581
2005 Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (New York, N.Y.). 310: 1642-6. PMID 16308421 DOI: 10.1126/Science.1120781  0.728
2005 Luo J, McMullen JR, Sobkiw CL, Zhang L, Dorfman AL, Sherwood MC, Logsdon MN, Horner JW, DePinho RA, Izumo S, Cantley LC. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Molecular and Cellular Biology. 25: 9491-502. PMID 16227599 DOI: 10.1128/Mcb.25.21.9491-9502.2005  0.552
2005 Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Advances in Enzyme Regulation. 45: 171-85. PMID 16199078 DOI: 10.1016/J.Advenzreg.2005.02.010  0.694
2005 Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. The Journal of Biological Chemistry. 280: 37489-94. PMID 16166093 DOI: 10.1074/Jbc.M506967200  0.321
2005 Luo J, Cantley LC. The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer. Cell Cycle (Georgetown, Tex.). 4: 1309-12. PMID 16131837 DOI: 10.4161/Cc.4.10.2062  0.616
2005 Mukohara T, Engelman JA, Hanna NH, Yeap BY, Kobayashi S, Lindeman N, Halmos B, Pearlberg J, Tsuchihashi Z, Cantley LC, Tenen DG, Johnson BE, Jänne PA. Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations. Journal of the National Cancer Institute. 97: 1185-94. PMID 16106023 DOI: 10.1093/Jnci/Dji238  0.329
2005 Field SJ, Madson N, Kerr ML, Galbraith KA, Kennedy CE, Tahiliani M, Wilkins A, Cantley LC. PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis. Current Biology : Cb. 15: 1407-12. PMID 16085494 DOI: 10.1016/J.Cub.2005.06.059  0.7
2005 Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. The Journal of Cell Biology. 170: 455-64. PMID 16043515 DOI: 10.1083/Jcb.200503088  0.765
2005 Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC. Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes & Development. 19: 1773-8. PMID 16027169 DOI: 10.1101/Gad.1314605  0.341
2005 Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10238-43. PMID 16006513 DOI: 10.1073/Pnas.0504378102  0.6
2005 Keilhack H, David FS, McGregor M, Cantley LC, Neel BG. Diverse biochemical properties of Shp2 mutants: Implications for disease phenotypes Journal of Biological Chemistry. 280: 30984-30993. PMID 15987685 DOI: 10.1074/Jbc.M504699200  0.327
2005 Kang CM, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes & Development. 19: 1692-704. PMID 15985609 DOI: 10.1101/Gad.1311105  0.416
2005 Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L. Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation. Proceedings of the National Academy of Sciences of the United States of America. 102: 8114-9. PMID 15928075 DOI: 10.1073/Pnas.0503141102  0.36
2005 Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjugate Chemistry. 16: 669-75. PMID 15898736 DOI: 10.1021/Bc049714F  0.768
2005 Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell. 121: 271-80. PMID 15851033 DOI: 10.1016/J.Cell.2005.02.019  0.632
2005 Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC. Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Molecular and Cellular Biology. 25: 2593-606. PMID 15767666 DOI: 10.1128/Mcb.25.7.2593-2606.2005  0.792
2005 Engelman JA, Jänne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE, Cantley LC. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proceedings of the National Academy of Sciences of the United States of America. 102: 3788-93. PMID 15731348 DOI: 10.1073/Pnas.0409773102  0.352
2005 Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. The Journal of Biological Chemistry. 280: 15158-64. PMID 15713674 DOI: 10.1074/Jbc.M412065200  0.335
2005 Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC. Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Molecular and Cellular Biology. 25: 1596-607. PMID 15713620 DOI: 10.1128/Mcb.25.5.1596-1607.2005  0.342
2004 Turk BE, Cantley LC. Peptide libraries: at the crossroads of proteomics and bioinformatics. Drug Discovery Today. 9: S47-52. PMID 23573644  0.534
2004 Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE. A rapid method for determining protein kinase phosphorylation specificity. Nature Methods. 1: 27-9. PMID 15782149 DOI: 10.1038/Nmeth708  0.786
2004 Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 12130-5. PMID 15302935 DOI: 10.1073/Pnas.0404720101  0.36
2004 Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6: 91-9. PMID 15261145 DOI: 10.1016/J.Ccr.2004.06.007  0.411
2004 Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. The Journal of Cell Biology. 166: 205-11. PMID 15249580 DOI: 10.1083/Jcb.200404150  0.732
2004 Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of Biological Chemistry. 279: 35950-7. PMID 15199048 DOI: 10.1074/Jbc.M405842200  0.563
2004 Halevy O, Cantley LC. Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells. Experimental Cell Research. 297: 224-34. PMID 15194438 DOI: 10.1016/J.Yexcr.2004.03.024  0.434
2004 Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Molecular and Cellular Biology. 24: 5080-7. PMID 15143198 DOI: 10.1128/Mcb.24.11.5080-5087.2004  0.725
2004 Turk BE, Cantley LC. Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes. Methods (San Diego, Calif.). 32: 398-405. PMID 15003602 DOI: 10.1016/J.Ymeth.2003.10.003  0.588
2004 Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proceedings of the National Academy of Sciences of the United States of America. 101: 3329-35. PMID 14985505 DOI: 10.1073/Pnas.0308061100  0.448
2004 Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, et al. Identification of small molecule inhibitors of anthrax lethal factor Nature Structural and Molecular Biology. 11: 67-72. PMID 14718925 DOI: 10.1038/Nsmb711  0.617
2004 Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nature Structural & Molecular Biology. 11: 60-6. PMID 14718924 DOI: 10.1038/Nsmb708  0.569
2004 Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC. Identification and characterization of a phosphoinositide phosphate kinase homolog. The Journal of Biological Chemistry. 279: 11672-9. PMID 14701839 DOI: 10.1074/Jbc.M309721200  0.734
2003 Manning BD, Cantley LC. Rheb fills a GAP between TSC and TOR. Trends in Biochemical Sciences. 28: 573-6. PMID 14607085 DOI: 10.1016/J.Tibs.2003.09.003  0.312
2003 Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 4: 257-62. PMID 14585353 DOI: 10.1016/S1535-6108(03)00248-4  0.535
2003 Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell. 115: 83-95. PMID 14532005 DOI: 10.1016/S0092-8674(03)00725-6  0.733
2003 Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. The Journal of Biological Chemistry. 278: 49417-27. PMID 14512424 DOI: 10.1074/Jbc.M308659200  0.595
2003 Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR. Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. The Journal of Biological Chemistry. 278: 48453-66. PMID 14504291 DOI: 10.1074/jbc.M305602200  0.794
2003 Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology : Cb. 13: 1259-68. PMID 12906785 DOI: 10.1016/S0960-9822(03)00506-2  0.303
2003 Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Proceedings of the National Academy of Sciences of the United States of America. 100: 9867-72. PMID 12897244 DOI: 10.1073/Pnas.1734038100  0.735
2003 Woolsey AM, Sunwoo L, Petersen CA, Brachmann SM, Cantley LC, Burleigh BA. Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. Journal of Cell Science. 116: 3611-22. PMID 12876217 DOI: 10.1242/Jcs.00666  0.357
2003 Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, ... ... Cantley LC, et al. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 114: 99-111. PMID 12859901 DOI: 10.1016/S0092-8674(03)00480-X  0.697
2003 Obenauer JC, Cantley LC, Yaffe MB. Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Research. 31: 3635-41. PMID 12824383 DOI: 10.1093/Nar/Gkg584  0.515
2003 Manning BD, Cantley LC. United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochemical Society Transactions. 31: 573-8. PMID 12773158 DOI: 10.1042/Bst0310573  0.418
2003 Katome T, Obata T, Matsushima R, Masuyama N, Cantley LC, Gotoh Y, Kishi K, Shiota H, Ebina Y. Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions. The Journal of Biological Chemistry. 278: 28312-23. PMID 12734182 DOI: 10.1074/Jbc.M302094200  0.346
2003 Elia AE, Cantley LC, Yaffe MB. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science (New York, N.Y.). 299: 1228-31. PMID 12595692 DOI: 10.1126/Science.1079079  0.732
2003 Turk BE, Cantley LC. Peptide libraries: at the crossroads of proteomics and bioinformatics. Current Opinion in Chemical Biology. 7: 84-90. PMID 12547431 DOI: 10.1016/S1367-5931(02)00004-2  0.578
2003 Hallmann D, Trümper K, Trusheim H, Ueki K, Kahn CR, Cantley LC, Fruman DA, Hörsch D. Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha. The Journal of Biological Chemistry. 278: 5099-108. PMID 12435753 DOI: 10.1074/Jbc.M208451200  0.411
2003 Cantley LC. Growth Factors Bind Receptor Tyrosine Kinases to Stimulate Cell Survival, Cell Division, Cell Growth, and Cytoskeletal Rearrangement Science Signaling. 2003: tr8-tr8. DOI: 10.1126/Stke.2122003Tr8  0.384
2002 Manning BD, Cantley LC. Hitting the target: emerging technologies in the search for kinase substrates. Science's Stke : Signal Transduction Knowledge Environment. 2002: pe49. PMID 12475999 DOI: 10.1126/Stke.2002.162.Pe49  0.377
2002 Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences of the United States of America. 99: 13571-6. PMID 12271141 DOI: 10.1073/Pnas.202476899  0.386
2002 Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Molecular Cell. 10: 151-62. PMID 12150915 DOI: 10.1016/S1097-2765(02)00568-3  0.409
2002 Park HI, Turk BE, Gerkema FE, Cantley LC, Sang QX. Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. The Journal of Biological Chemistry. 277: 35168-75. PMID 12119297 DOI: 10.1074/Jbc.M205071200  0.576
2002 Cantley LC. The phosphoinositide 3-kinase pathway. Science (New York, N.Y.). 296: 1655-7. PMID 12040186 DOI: 10.1126/Science.296.5573.1655  0.434
2002 Field SJ, Lamia KA, Rameh LE, Cantley LC. Lipid research picks up speed on the slopes of Taos. Developmental Cell. 2: 407-10. PMID 11970891 DOI: 10.1016/S1534-5807(02)00150-8  0.775
2002 Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S. Akt/protein kinase B promotes organ growth in transgenic mice. Molecular and Cellular Biology. 22: 2799-809. PMID 11909972 DOI: 10.1128/Mcb.22.8.2799-2809.2002  0.372
2002 Fruman DA, Cantley LC. Phosphoinositide 3-kinase in immunological systems. Seminars in Immunology. 14: 7-18. PMID 11884226 DOI: 10.1006/Smim.2001.0337  0.389
2002 Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Molecular and Cellular Biology. 22: 965-77. PMID 11784871 DOI: 10.1128/Mcb.22.3.965-977.2002  0.419
2002 Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. The Journal of Clinical Investigation. 109: 141-9. PMID 11781359 DOI: 10.1172/Jci13305  0.35
2002 Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC. Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 419-24. PMID 11752399 DOI: 10.1073/Pnas.012581799  0.793
2001 Singh VP, Saluja AK, Bhagat L, van Acker GJ, Song AM, Soltoff SP, Cantley LC, Steer ML. Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. The Journal of Clinical Investigation. 108: 1387-95. PMID 11696584 DOI: 10.1172/Jci12874  0.371
2001 Prejean C, Sarma T, Kurnasov O, Usacheva A, Hemmings B, Cantley L, Fruman DA, Morrison LA, Buller RM, Colamonici OR. Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors Journal of Immunology. 167: 4553-4559. PMID 11591783 DOI: 10.4049/Jimmunol.167.8.4553  0.407
2001 Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. The Journal of Cell Biology. 155: 19-25. PMID 11581283 DOI: 10.1083/Jcb.200107069  0.382
2001 Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nature Cell Biology. 3: 675-8. PMID 11433300 DOI: 10.1038/35083070  0.745
2001 Turk BE, Huang LL, Piro ET, Cantley LC. Determination of protease cleavage site motifs using mixture-based oriented peptide libraries Nature Biotechnology. 19: 661-667. PMID 11433279 DOI: 10.1038/90273  0.567
2001 Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death Molecular Cell. 7: 1307-1319. PMID 11430832 DOI: 10.1016/S1097-2765(01)00258-1  0.371
2001 Sweeney C, Fambrough D, Huard C, Diamonti AJ, Lander ES, Cantley LC, Carraway KL. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. The Journal of Biological Chemistry. 276: 22685-98. PMID 11297548 DOI: 10.1074/Jbc.M100602200  0.374
2001 Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nature Biotechnology. 19: 348-53. PMID 11283593 DOI: 10.1038/86737  0.522
2001 Bertenshaw GP, Turk BE, Hubbard SJ, Matters GL, Bylander JE, Crisman JM, Cantley LC, Bond JS. Marked Differences between Metalloproteases Meprin A and B in Substrate and Peptide Bond Specificity Journal of Biological Chemistry. 276: 13248-13255. PMID 11278902 DOI: 10.1074/Jbc.M011414200  0.579
2000 Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. The Embo Journal. 19: 6778-91. PMID 11118213 DOI: 10.1093/Emboj/19.24.6778  0.516
2000 Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC. A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. Molecular Cell. 6: 969-74. PMID 11090635 DOI: 10.1016/S1097-2765(05)00085-7  0.531
2000 Yaffe MB, Cantley LC. Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods in Enzymology. 328: 157-70. PMID 11075345 DOI: 10.1016/S0076-6879(00)28397-3  0.487
2000 Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT, Kahn CR, Cantley LC. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nature Genetics. 26: 379-82. PMID 11062485 DOI: 10.1038/81715  0.785
2000 Luo J, Cantley LC. Phosphoinositide biology – messages from lipids Nature Cell Biology. 2. PMID 11025682 DOI: 10.1038/35036447  0.486
2000 Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. The Journal of Biological Chemistry. 275: 36108-15. PMID 10945990 DOI: 10.1074/Jbc.M005497200  0.577
2000 Sweeney C, Lai C, Riese DJ, Diamonti AJ, Cantley LC, Carraway KL. Ligand discrimination in signaling through an ErbB4 receptor homodimer. The Journal of Biological Chemistry. 275: 19803-7. PMID 10867024 DOI: 10.1074/Jbc.C901015199  0.327
2000 Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J, Cantley LC, Izumo S. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. The Embo Journal. 19: 2537-48. PMID 10835352 DOI: 10.1093/Emboj/19.11.2537  0.793
2000 Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. 97: 6687-92. PMID 10829070 DOI: 10.1073/Pnas.110146697  0.392
2000 O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP, Abraham RH, Lai JH, Hill D, Shiloh Y, Cantley LC, Rathbun GA. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. The Journal of Biological Chemistry. 275: 22719-27. PMID 10801797 DOI: 10.1074/Jbc.M001002200  0.324
2000 Lu-Kuo JM, Fruman DA, Joyal DM, Cantley LC, Katz HR. Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. The Journal of Biological Chemistry. 275: 6022-9. PMID 10681597 DOI: 10.1074/Jbc.275.8.6022  0.42
2000 Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL. Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Current Biology : Cb. 10: 153-6. PMID 10679324 DOI: 10.1016/S0960-9822(00)00315-8  0.353
2000 Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. The Journal of Biological Chemistry. 275: 2219-30. PMID 10636929 DOI: 10.1074/Jbc.275.3.2219  0.56
2000 Beitz LO, Fruman DA, Kurosaki T, Cantley LC, Scharenberg AM. SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. The Journal of Biological Chemistry. 274: 32662-6. PMID 10551821 DOI: 10.1074/Jbc.274.46.32662  0.397
1999 Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochemical Society Transactions. 27: 624-9. PMID 10917654 DOI: 10.1042/Bst0270624  0.772
1999 Yaffe MB, Cantley LC. Signal transduction. Grabbing phosphoproteins. Nature. 402: 30-1. PMID 10573413 DOI: 10.1038/46925  0.522
1999 Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Molecular Cell. 4: 555-61. PMID 10549287 DOI: 10.1016/S1097-2765(00)80206-3  0.507
1999 Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (New York, N.Y.). 285: 2129-33. PMID 10497131 DOI: 10.1126/Science.285.5436.2129  0.602
1999 Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB. Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Molecular Cell. 4: 153-66. PMID 10488331 DOI: 10.1016/S1097-2765(00)80363-9  0.499
1999 Aksoy IA, Ramsey MJ, Fruman DA, Aksoy S, Cantley LC, Tucker JD, Roberts TM. Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Biochemical and Biophysical Research Communications. 262: 438-42. PMID 10462494 DOI: 10.1006/Bbrc.1999.1150  0.328
1999 Tolias KF, Cantley LC. Pathways for phosphoinositide synthesis. Chemistry and Physics of Lipids. 98: 69-77. PMID 10358929 DOI: 10.1016/S0009-3084(99)00019-5  0.413
1999 Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proceedings of the National Academy of Sciences of the United States of America. 96: 4240-5. PMID 10200246 DOI: 10.1073/Pnas.96.8.4240  0.411
1999 Rameh LE, Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. The Journal of Biological Chemistry. 274: 8347-50. PMID 10085060 DOI: 10.1074/Jbc.274.13.8347  0.349
1999 Gupta N, Scharenberg AM, Fruman DA, Cantley LC, Kinet JP, Long EO. The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling. The Journal of Biological Chemistry. 274: 7489-94. PMID 10066815 DOI: 10.1074/Jbc.274.11.7489  0.424
1999 Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (New York, N.Y.). 283: 393-7. PMID 9888855 DOI: 10.1126/Science.283.5400.393  0.805
1999 Fruman DA, Snapper SB, Yballe CM, Mauvais-Jarvis F, Kahn CR, Alt FW, Cantley LC. PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION Biochemical Society Transactions. 27: A73-A73. DOI: 10.1042/Bst027A073C  0.8
1998 Meyers RE, Cantley LC. Phosphatidylinositol 4-kinases. Assays and product analysis. Methods in Molecular Biology (Clifton, N.J.). 105: 99-108. PMID 10427554 DOI: 10.1385/0-89603-491-7:99  0.318
1998 Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Molecular Cell. 2: 353-9. PMID 9774973 DOI: 10.1016/S1097-2765(00)80279-8  0.557
1998 Crovello CS, Lai C, Cantley LC, Carraway KL. Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2 Journal of Biological Chemistry. 273: 26954-26961. PMID 9756944 DOI: 10.1074/Jbc.273.41.26954  0.346
1998 Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG. Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. The Journal of Biological Chemistry. 273: 23750-7. PMID 9726983 DOI: 10.1074/Jbc.273.37.23750  0.345
1998 Nishikawa K, Toker A, Wong K, Marignani PA, Johannes FJ, Cantley LC. Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. The Journal of Biological Chemistry. 273: 23126-33. PMID 9722541 DOI: 10.1074/Jbc.273.36.23126  0.627
1998 Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate. The Journal of Biological Chemistry. 273: 18040-6. PMID 9660759 DOI: 10.1074/Jbc.273.29.18040  0.331
1998 Scharenberg AM, El-Hillal O, Fruman DA, Beitz LO, Li Z, Lin S, Gout I, Cantley LC, Rawlings DJ, Kinet JP. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. The Embo Journal. 17: 1961-72. PMID 9524119 DOI: 10.1093/Emboj/17.7.1961  0.396
1998 Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene. 16: 891-901. PMID 9484780 DOI: 10.1038/Sj.Onc.1201607  0.355
1998 Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD. SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. The Journal of Cell Biology. 140: 737-50. PMID 9472028 DOI: 10.1083/Jcb.140.4.737  0.394
1998 Tolias KF, Couvillon AD, Cantley LC, Carpenter CL. Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Molecular and Cellular Biology. 18: 762-70. PMID 9447972 DOI: 10.1128/Mcb.18.2.762  0.406
1998 Borgatti P, Zauli G, Cantley LC, Capitani S. Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. Biochemical and Biophysical Research Communications. 242: 332-7. PMID 9446795 DOI: 10.1006/Bbrc.1997.7877  0.358
1998 Soltoff SP, Avraham H, Avraham S, Cantley LC. Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. The Journal of Biological Chemistry. 273: 2653-60. PMID 9446569 DOI: 10.1074/Jbc.273.5.2653  0.394
1998 Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, Sakelis C, Patki V, Corvera S, Czech MP. Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. The Journal of Biological Chemistry. 273: 1859-62. PMID 9442017 DOI: 10.1074/Jbc.273.4.1859  0.314
1997 Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 91: 961-71. PMID 9428519 DOI: 10.1016/S0092-8674(00)80487-0  0.486
1997 Lupher ML, Songyang Z, Shoelson SE, Cantley LC, Band H. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. The Journal of Biological Chemistry. 272: 33140-4. PMID 9407100 DOI: 10.1074/Jbc.272.52.33140  0.329
1997 Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (New York, N.Y.). 278: 1957-60. PMID 9395400 DOI: 10.1126/Science.278.5345.1957  0.544
1997 Rameh LE, Tolias KF, Duckworth BC, Cantley LC. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature. 390: 192-6. PMID 9367159 DOI: 10.1038/36621  0.341
1997 Franke TF, Cantley LC. Apoptosis. A Bad kinase makes good. Nature. 390: 116-7. PMID 9367147 DOI: 10.1038/36442  0.354
1997 Duckworth BC, Cantley LC. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. The Journal of Biological Chemistry. 272: 27665-70. PMID 9346906 DOI: 10.1074/Jbc.272.44.27665  0.399
1997 Songyang Z, Baltimore D, Cantley LC, Kaplan DR, Franke TF. Interleukin 3-dependent survival by the Akt protein kinase Proceedings of the National Academy of Sciences of the United States of America. 94: 11345-11350. PMID 9326612 DOI: 10.1073/Pnas.94.21.11345  0.367
1997 Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. The Embo Journal. 16: 3877-88. PMID 9233798 DOI: 10.1093/Emboj/16.13.3877  0.369
1997 Ruzzene M, Songyang Z, Marin O, Donella-Deana A, Brunati AM, Guerra B, Agostinis P, Cantley LC, Pinna LA. Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn. European Journal of Biochemistry / Febs. 246: 433-9. PMID 9208935 DOI: 10.1111/J.1432-1033.1997.T01-1-00433.X  0.335
1997 Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature. 387: 673-6. PMID 9192891 DOI: 10.1038/42648  0.6
1997 Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase Science. 276: 1848-1850. PMID 9188528 DOI: 10.1126/Science.276.5320.1848  0.347
1997 Wong K, Cantley LC. Subcellular locations of phosphatidylinositol 4-kinase isoforms. The Journal of Biological Chemistry. 272: 13236-41. PMID 9148941 DOI: 10.1074/Jbc.272.20.13236  0.377
1997 Klingmüller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proceedings of the National Academy of Sciences of the United States of America. 94: 3016-21. PMID 9096338 DOI: 10.1073/Pnas.94.7.3016  0.643
1997 Derman MP, Toker A, Hartwig JH, Spokes K, Falck JR, Chen CS, Cantley LC, Cantley LG. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. The Journal of Biological Chemistry. 272: 6465-70. PMID 9045671 DOI: 10.1074/Jbc.272.10.6465  0.638
1997 Franke TF, Kaplan DR, Cantley LC. PI3K: Downstream AKTion blocks apoptosis Cell. 88: 435-437. PMID 9038334 DOI: 10.1016/S0092-8674(00)81883-8  0.326
1997 Meyers R, Cantley LC. Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. The Journal of Biological Chemistry. 272: 4384-90. PMID 9020160 DOI: 10.1074/Jbc.272.7.4384  0.396
1997 Franke TF, Kaplan DR, Cantley LC, Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate Science. 275: 665-668. PMID 9005852 DOI: 10.1126/Science.275.5300.665  0.625
1997 Nishikawa K, Toker A, Johannes FJ, Songyang Z, Cantley LC. Determination of the specific substrate sequence motifs of protein kinase C isozymes. The Journal of Biological Chemistry. 272: 952-60. PMID 8995387 DOI: 10.1074/Jbc.272.2.952  0.57
1997 Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. The Journal of Biological Chemistry. 271: 32986-93. PMID 8955143 DOI: 10.1074/Jbc.271.51.32986  0.586
1996 Vikkula M, Boon LM, Carraway KL, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA, Marchuk DA, Warman ML, Cantley LC, Mulliken JB, Olsen BR. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2 Cell. 87: 1181-1190. PMID 8980225 DOI: 10.1016/S0092-8674(00)81814-0  0.328
1996 Osborne MA, Zenner G, Lubinus M, Zhang X, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP. The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation Journal of Biological Chemistry. 271: 29271-29278. PMID 8910587 DOI: 10.1074/Jbc.271.46.29271  0.363
1996 Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Molecular and Cellular Biology. 16: 6486-93. PMID 8887677 DOI: 10.1128/Mcb.16.11.6486  0.369
1996 Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Molecular and Cellular Biology. 16: 5905-14. PMID 8816504 DOI: 10.1128/Mcb.16.10.5905  0.363
1996 Couture C, Songyang Z, Jascur T, Williams S, Tailor P, Cantley LC, Mustelin T. Regulation of the Lck SH2 domain by tyrosine phosphorylation. The Journal of Biological Chemistry. 271: 24880-4. PMID 8798764 DOI: 10.1074/Jbc.271.40.24880  0.361
1996 Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S. Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. The Journal of Biological Chemistry. 271: 22961-4. PMID 8798481 DOI: 10.1074/Jbc.271.38.22961  0.392
1996 Carpenter CL, Cantley LC. Phosphoinositide 3-kinase and the regulation of cell growth. Biochimica Et Biophysica Acta. 1288: M11-6. PMID 8764841 DOI: 10.1016/0304-419X(96)00018-2  0.394
1996 Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with fyn and Syk tyrosine kinases, Grb2 and she adaptors, and the p85 subunit of phosphatidylinositol 3-kinase Journal of Biological Chemistry. 271: 3187-3194. PMID 8621719 DOI: 10.1074/Jbc.271.6.3187  0.387
1996 O'Bryan JP, Songyang Z, Cantley L, Der CJ, Pawson T. A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proceedings of the National Academy of Sciences of the United States of America. 93: 2729-34. PMID 8610109 DOI: 10.1073/Pnas.93.7.2729  0.314
1996 Bachelot C, Rameh L, Parsons T, Cantley LC. Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts. Biochimica Et Biophysica Acta. 1311: 45-52. PMID 8603102 DOI: 10.1016/0167-4889(95)00176-X  0.369
1996 Songyang Z, Cantley LC. Recognition and specificity in protein tyrosine kinase-mediated signalling. Trends in Biochemical Sciences. 20: 470-5. PMID 8578591 DOI: 10.1016/S0968-0004(00)89103-3  0.331
1996 Soltoff SP, Cantley LC. p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells. The Journal of Biological Chemistry. 271: 563-7. PMID 8550620 DOI: 10.1074/Jbc.271.1.563  0.415
1996 Songyang Z, Cantley LC. SH2 domain specificity determination using oriented phosphopeptide library. Methods in Enzymology. 254: 523-35. PMID 8531712 DOI: 10.1016/0076-6879(95)54037-7  0.32
1996 Rameh LE, Chen CS, Cantley LC. Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell. 83: 821-30. PMID 8521499 DOI: 10.1016/0092-8674(95)90195-7  0.384
1996 Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. The Journal of Biological Chemistry. 270: 29525-31. PMID 7493994 DOI: 10.1074/Jbc.270.49.29525  0.611
1995 Pertile P, Liscovitch M, Chalifa V, Cantley LC. Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells. The Journal of Biological Chemistry. 270: 5130-5. PMID 7890622 DOI: 10.1074/Jbc.270.10.5130  0.386
1995 Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 80: 729-38. PMID 7889566 DOI: 10.1016/0092-8674(95)90351-8  0.334
1995 Pertile P, Cantley LC. Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking. Biochimica Et Biophysica Acta. 1248: 129-34. PMID 7748894 DOI: 10.1016/0167-4838(95)00016-N  0.315
1995 Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B, Cantley LC, Hartwig JH. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. The Journal of Biological Chemistry. 270: 11358-66. PMID 7744773 DOI: 10.1074/Jbc.270.19.11358  0.579
1995 Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H. The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 270: 19141-50. PMID 7642581 DOI: 10.1074/Jbc.270.32.19141  0.396
1995 Tolias KF, Cantley LC, Carpenter CL. Rho family GTPases bind to phosphoinositide kinases. The Journal of Biological Chemistry. 270: 17656-9. PMID 7629060 DOI: 10.1074/Jbc.270.30.17656  0.381
1995 Kapeller R, Toker A, Cantley LC, Carpenter CL. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. The Journal of Biological Chemistry. 270: 25985-91. PMID 7592789 DOI: 10.1074/Jbc.270.43.25985  0.628
1995 Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. The Journal of Biological Chemistry. 270: 20177-82. PMID 7544353 DOI: 10.1074/Jbc.270.34.20177  0.371
1995 Carraway KL, Soltoff SP, Diamonti AJ, Cantley LC. Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3 Journal of Biological Chemistry. 270: 7111-7116. PMID 7535767 DOI: 10.1074/Jbc.270.13.7111  0.385
1994 Kanakaraj P, Duckworth B, Azzoni L, Kamoun M, Cantley LC, Perussia B. Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction. The Journal of Experimental Medicine. 179: 551-8. PMID 8294866 DOI: 10.1084/Jem.179.2.551  0.393
1994 Prasad KV, Kapeller R, Janssen O, Repke H, Duke-Cohan JS, Cantley LC, Rudd CE. Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase. Molecular and Cellular Biology. 13: 7708-17. PMID 8246987 DOI: 10.1128/Mcb.13.12.7708  0.368
1994 Prasad KV, Cai YC, Raab M, Duckworth B, Cantley L, Shoelson SE, Rudd CE. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proceedings of the National Academy of Sciences of the United States of America. 91: 2834-8. PMID 8146197 DOI: 10.1073/Pnas.91.7.2834  0.355
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