Zhong-Yin Zhang - Publications

Affiliations: 
Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Biochemistry, Analytical Chemistry, Molecular Biology

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Lane BS, Shim JS, Zeng LF, He Y, Chen L, Wells CD, Liu JO, Zhang ZY. Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. Acs Medicinal Chemistry Letters. 6: 782-6. PMID 26191366 DOI: 10.1021/acsmedchemlett.5b00118  0.4
2015 He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY. A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. Bioorganic & Medicinal Chemistry. 23: 2798-809. PMID 25907364 DOI: 10.1016/j.bmc.2015.03.066  0.4
2015 Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell. 160: 88-104. PMID 25594176 DOI: 10.1016/j.cell.2014.12.022  0.4
2014 Paudyal MP, Wu L, Zhang ZY, Spilling CD, Wong CF. A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis. Bioorganic & Medicinal Chemistry. 22: 6781-8. PMID 25468042 DOI: 10.1016/j.bmc.2014.10.042  0.4
2014 Sharma N, Everingham S, Zeng LF, Zhang ZY, Kapur R, Craig AW. Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice. Oncotarget. 5: 6130-41. PMID 25026279  0.4
2014 Zeng LF, Zhang RY, Yu ZH, Li S, Wu L, Gunawan AM, Lane BS, Mali RS, Li X, Chan RJ, Kapur R, Wells CD, Zhang ZY. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. Journal of Medicinal Chemistry. 57: 6594-609. PMID 25003231 DOI: 10.1021/jm5006176  0.4
2014 Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A. Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. The Journal of Clinical Investigation. 124: 3295-310. PMID 24983314 DOI: 10.1172/JCI71668  0.4
2014 Yu ZH, Zhang RY, Walls CD, Chen L, Zhang S, Wu L, Liu S, Zhang ZY. Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry. 53: 4136-51. PMID 24935154 DOI: 10.1021/bi5002695  0.4
2014 Kobayashi M, Bai Y, Dong Y, Yu H, Chen S, Gao R, Zhang L, Yoder MC, Kapur R, Zhang ZY, Liu Y. PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Stem Cells (Dayton, Ohio). 32: 1956-67. PMID 24753135 DOI: 10.1002/stem.1672  0.4
2014 Liao J, Wu CX, Burlak C, Zhang S, Sahm H, Wang M, Zhang ZY, Vogel KW, Federici M, Riddle SM, Nichols RJ, Liu D, Cookson MR, Stone TA, Hoang QQ. Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain. Proceedings of the National Academy of Sciences of the United States of America. 111: 4055-60. PMID 24591621 DOI: 10.1073/pnas.1323285111  0.4
2014 Yakubov B, Chen L, Belkin AM, Zhang S, Chelladurai B, Zhang ZY, Matei D. Small molecule inhibitors target the tissue transglutaminase and fibronectin interaction. Plos One. 9: e89285. PMID 24586660 DOI: 10.1371/journal.pone.0089285  0.4
2014 Campbell AM, Zhang ZY. Phosphatase of regenerating liver: a novel target for cancer therapy. Expert Opinion On Therapeutic Targets. 18: 555-69. PMID 24579927 DOI: 10.1517/14728222.2014.892926  0.4
2014 Dong Y, Zhang L, Bai Y, Zhou HM, Campbell AM, Chen H, Yong W, Zhang W, Zeng Q, Shou W, Zhang ZY. Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis. The Journal of Biological Chemistry. 289: 3799-810. PMID 24371141 DOI: 10.1074/jbc.M113.512079  0.4
2014 Selner NG, Luechapanichkul R, Chen X, Neel BG, Zhang ZY, Knapp S, Bell CE, Pei D. Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. Biochemistry. 53: 397-412. PMID 24359314 DOI: 10.1021/bi401223r  0.4
2013 Xu J, Zeng LF, Shen W, Turchi JJ, Zhang ZY. Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma. Biochemical and Biophysical Research Communications. 439: 586-90. PMID 24041688 DOI: 10.1016/j.bbrc.2013.09.028  0.4
2013 Gan Y, Zhang Y, Buckels A, Paterson AJ, Jiang J, Clemens TL, Zhang ZY, Du K, Chang Y, Frank SJ. IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity. Molecular Endocrinology (Baltimore, Md.). 27: 1969-79. PMID 24030252 DOI: 10.1210/me.2013-1178  0.4
2013 Walls CD, Iliuk A, Bai Y, Wang M, Tao WA, Zhang ZY. Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Molecular & Cellular Proteomics : McP. 12: 3759-77. PMID 24030100 DOI: 10.1074/mcp.M113.028886  0.4
2013 Dumaual CM, Steere BA, Walls CD, Wang M, Zhang ZY, Randall SK. Integrated analysis of global mRNA and protein expression data in HEK293 cells overexpressing PRL-1. Plos One. 8: e72977. PMID 24019887 DOI: 10.1371/journal.pone.0072977  0.4
2013 He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. Journal of Medicinal Chemistry. 56: 4990-5008. PMID 23713581 DOI: 10.1021/jm400248c  0.4
2013 Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, et al. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of Biological Chemistry. 288: 17360-71. PMID 23640882 DOI: 10.1074/jbc.M112.441469  0.4
2013 Yu ZH, Xu J, Walls CD, Chen L, Zhang S, Zhang R, Wu L, Wang L, Liu S, Zhang ZY. Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations. The Journal of Biological Chemistry. 288: 10472-82. PMID 23457302 DOI: 10.1074/jbc.M113.450023  0.4
2012 Carbone CJ, Zheng H, Bhattacharya S, Lewis JR, Reiter AM, Henthorn P, Zhang ZY, Baker DP, Ukkiramapandian R, Bence KK, Fuchs SY. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proceedings of the National Academy of Sciences of the United States of America. 109: 19226-31. PMID 23129613 DOI: 10.1073/pnas.1211491109  0.4
2012 Zhang S, Chen L, Lawrence DS, Zhang ZY. A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors. Methods in Molecular Biology (Clifton, N.J.). 928: 53-65. PMID 22956133 DOI: 10.1007/978-1-62703-008-3_5  0.4
2012 Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America. 109: 13972-7. PMID 22891353 DOI: 10.1073/pnas.1205028109  0.4
2012 Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, ... ... Zhang ZY, et al. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 120: 2669-78. PMID 22806893 DOI: 10.1182/blood-2011-08-375873  0.4
2012 Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY. Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. The Journal of Biological Chemistry. 287: 32172-9. PMID 22791713 DOI: 10.1074/jbc.M112.393462  0.4
2012 Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann K, Roers A, Craig AW. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Molecular and Cellular Biology. 32: 2653-63. PMID 22566685 DOI: 10.1128/MCB.00308-12  0.4
2012 Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL. Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Cellular Signalling. 24: 1064-73. PMID 22261254 DOI: 10.1016/j.cellsig.2012.01.001  0.4
2011 Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, Zhang ZY. PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. The Journal of Biological Chemistry. 286: 42316-24. PMID 22009749 DOI: 10.1074/jbc.M111.286302  0.4
2011 Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, et al. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metabolism. 14: 684-99. PMID 22000926 DOI: 10.1016/j.cmet.2011.09.011  0.4
2011 Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes & Development. 25: 2069-78. PMID 21979919 DOI: 10.1101/gad.17224711  0.4
2011 Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry. 54: 1640-54. PMID 21341673 DOI: 10.1021/jm101202j  0.4
2011 Liu S, Yu Z, Yu X, Huang SX, Luo Y, Wu L, Shen W, Yang Z, Wang L, Gunawan AM, Chan RJ, Shen B, Zhang ZY. SHP2 is a target of the immunosuppressant tautomycetin. Chemistry & Biology. 18: 101-10. PMID 21276943 DOI: 10.1016/j.chembiol.2010.10.015  0.4
2011 Piovan L, Wu L, Zhang ZY, Andrade LH. Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases Organic and Biomolecular Chemistry. 9: 1347-1351. PMID 21240419 DOI: 10.1039/c0ob01050b  0.4
2010 Chen L, Zhou B, Zhang S, Wu L, Wang Y, Franzblau SG, Zhang ZY. Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis. Acs Medicinal Chemistry Letters. 1: 355-359. PMID 21116447 DOI: 10.1021/ml1001135  0.4
2010 Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). Journal of Medicinal Chemistry. 53: 2482-93. PMID 20170098 DOI: 10.1021/jm901645u  0.4
2010 Zhou B, He Y, Zhang X, Xu J, Luo Y, Wang Y, Franzblau SG, Yang Z, Chan RJ, Liu Y, Zheng J, Zhang ZY. Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents. Proceedings of the National Academy of Sciences of the United States of America. 107: 4573-8. PMID 20167798 DOI: 10.1073/pnas.0909133107  0.4
2009 Zhang S, Chen L, Luo Y, Gunawan A, Lawrence DS, Zhang ZY. Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. Journal of the American Chemical Society. 131: 13072-9. PMID 19737019 DOI: 10.1021/ja903733z  0.4
2009 Zhang W, Chan RJ, Chen H, Yang Z, He Y, Zhang X, Luo Y, Yin F, Moh A, Miller LC, Payne RM, Zhang ZY, Fu XY, Shou W. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. The Journal of Biological Chemistry. 284: 22353-63. PMID 19509418 DOI: 10.1074/jbc.M109.020495  0.4
2009 Walls C, Zhou B, Zhang ZY. Activity-based protein profiling of protein tyrosine phosphatases. Methods in Molecular Biology (Clifton, N.J.). 519: 417-29. PMID 19381599 DOI: 10.1007/978-1-59745-281-6_27  0.4
2009 Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, ... ... Zhang ZY, et al. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Human Molecular Genetics. 18: 569-79. PMID 18981062 DOI: 10.1093/hmg/ddn363  0.4
2008 Abdo M, Liu S, Zhou B, Walls CD, Wu L, Knapp S, Zhang ZY. Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases. Journal of the American Chemical Society. 130: 13196-7. PMID 18781746 DOI: 10.1021/ja804489m  0.4
2008 Liang F, Luo Y, Dong Y, Walls CD, Liang J, Jiang HY, Sanford JR, Wek RC, Zhang ZY. Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase. The Journal of Biological Chemistry. 283: 10339-46. PMID 18268019 DOI: 10.1074/jbc.M708285200  0.4
2007 Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, ... ... Zhang ZY, et al. Structural genomics of protein phosphatases. Journal of Structural and Functional Genomics. 8: 121-40. PMID 18058037 DOI: 10.1007/s10969-007-9036-1  0.4
2007 Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America. 104: 19767-72. PMID 18056643 DOI: 10.1073/pnas.0706233104  0.4
2007 Zhang S, Chen L, Kumar S, Wu L, Lawrence DS, Zhang ZY. An affinity-based fluorescence polarization assay for protein tyrosine phosphatases. Methods (San Diego, Calif.). 42: 261-7. PMID 17532513 DOI: 10.1016/j.ymeth.2007.02.008  0.4
2007 Khajehpour M, Wu L, Liu S, Zhadin N, Zhang ZY, Callender R. Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase. Biochemistry. 46: 4370-8. PMID 17352459 DOI: 10.1021/bi602335x  0.4
2007 Boutselis IG, Yu X, Zhang ZY, Borch RF. Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug. Journal of Medicinal Chemistry. 50: 856-64. PMID 17249650 DOI: 10.1021/jm061146x  0.4
2007 Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. The Journal of Biological Chemistry. 282: 5413-9. PMID 17192274 DOI: 10.1074/jbc.M608940200  0.4
2007 Morrison CD, White CL, Wang Z, Lee SY, Lawrence DS, Cefalu WT, Zhang ZY, Gettys TW. Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology. 148: 433-40. PMID 17038557 DOI: 10.1210/en.2006-0672  0.4
2006 Cui Y, Parra I, Zhang M, Hilsenbeck SG, Tsimelzon A, Furukawa T, Horii A, Zhang ZY, Nicholson RI, Fuqua SA. Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. Cancer Research. 66: 5950-9. PMID 16740736 DOI: 10.1158/0008-5472.CAN-05-3243  0.4
2006 Lee H, Xie L, Luo Y, Lee SY, Lawrence DS, Wang XB, Sotgia F, Lisanti MP, Zhang ZY. Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate. Biochemistry. 45: 234-40. PMID 16388599 DOI: 10.1021/bi051560j  0.4
2005 Sun JP, Wang WQ, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry. 44: 12009-21. PMID 16142898 DOI: 10.1021/bi0509191  0.4
2005 Lee K, Boovanahalli SK, Nam KY, Kang SU, Lee M, Phan J, Wu L, Waugh DS, Zhang ZY, No KT, Lee JJ, Burke TR. Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 4037-42. PMID 16039123 DOI: 10.1016/j.bmcl.2005.06.027  0.4
2005 Lee SY, Liang F, Guo XL, Xie L, Cahill SM, Blumenstein M, Yang H, Lawrence DS, Zhang ZY. Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor. Angewandte Chemie (International Ed. in English). 44: 4242-4. PMID 15937885 DOI: 10.1002/anie.200462004  0.4
2005 Liang F, Lee SY, Liang J, Lawrence DS, Zhang ZY. The role of protein-tyrosine phosphatase 1B in integrin signaling. The Journal of Biological Chemistry. 280: 24857-63. PMID 15866871 DOI: 10.1074/jbc.M502780200  0.4
2005 Kumar S, Liang F, Lawrence DS, Zhang ZY. Small molecule approach to studying protein tyrosine phosphatase. Methods (San Diego, Calif.). 35: 9-21. PMID 15588981 DOI: 10.1016/j.ymeth.2004.07.003  0.4
2004 McCain DF, Grzyska PK, Wu L, Hengge AC, Zhang ZY. Mechanistic studies of protein tyrosine phosphatases YopH and Cdc25A with m-nitrobenzyl phosphate. Biochemistry. 43: 8256-64. PMID 15209522 DOI: 10.1021/bi0496182  0.4
Show low-probability matches.