Zhong-Yin Zhang - Publications

Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Biochemistry, Analytical Chemistry, Molecular Biology

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Gebregiworgis T, Kano Y, St-Germain J, Radulovich N, Udaskin ML, Mentes A, Huang R, Poon BPK, He W, Valencia-Sama I, Robinson CM, Huestis M, Miao J, Yeh JJ, Zhang ZY, et al. The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors. Nature Communications. 12: 6274. PMID 34725361 DOI: 10.1038/s41467-021-26526-y  0.301
2021 Krabill AD, Zhang ZY. Functional interrogation and therapeutic targeting of protein tyrosine phosphatases. Biochemical Society Transactions. 49: 1723-1734. PMID 34431504 DOI: 10.1042/BST20201308  0.307
2021 Xu YF, Chen X, Yang Z, Xiao P, Liu CH, Li KS, Yang XZ, Wang YJ, Zhu ZL, Xu ZG, Zhang S, Wang C, Song YC, Zhao WD, Wang CH, ... ... Zhang ZY, et al. PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Reports. e52141. PMID 33764618 DOI: 10.15252/embr.202052141  0.713
2020 Chen H, Libring S, Ruddraraju KV, Miao J, Solorio L, Zhang ZY, Wendt MK. SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer. Oncogene. PMID 33033382 DOI: 10.1038/s41388-020-01488-5  0.313
2020 Zhu G, Xie J, Kong W, Xie J, Li Y, Du L, Zheng Q, Sun L, Guan M, Li H, Zhu T, He H, Liu Z, Xia X, Kan C, ... ... Zhang ZY, et al. Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation. Cell. PMID 33002410 DOI: 10.1016/j.cell.2020.09.002  0.345
2020 Li Q, Bai Y, Lyle LT, Yu G, Amarasinghe O, Nguele Meke F, Carlock C, Zhang ZY. Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 32788364 DOI: 10.1073/Pnas.2002964117  0.385
2020 Ruddraraju KV, Aggarwal D, Niu C, Baker EA, Zhang RY, Wu L, Zhang ZY. Highly Potent and Selective N-aryl Oxamic Acid Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (mPTPB). Journal of Medicinal Chemistry. PMID 32787087 DOI: 10.1021/Acs.Jmedchem.0C00302  0.346
2020 Zhang RY, Yu ZH, Chen L, Walls CD, Zhang S, Wu L, Zhang ZY. Mechanistic insights explain the transforming potential of the T507K substitution in the protein tyrosine phosphatase SHP2. The Journal of Biological Chemistry. PMID 32188694 DOI: 10.1074/Jbc.Ra119.010274  0.76
2019 Li Y, Gardner JJ, Fortney KR, Leus IV, Bonifay V, Zgurskaya HI, Pletnev AA, Zhang S, Zhang ZY, Gribble GW, Spinola SM, Duerfeldt AS. First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 31104993 DOI: 10.1016/J.Bmcl.2019.05.003  0.354
2019 Kano Y, Gebregiworgis T, Marshall CB, Radulovich N, Poon BPK, St-Germain J, Cook JD, Valencia-Sama I, Grant BMM, Herrera SG, Miao J, Raught B, Irwin MS, Lee JE, Yeh JJ, ... Zhang ZY, et al. Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation. Nature Communications. 10: 224. PMID 30644389 DOI: 10.1038/S41467-018-08115-8  0.306
2018 Davis DC, Hoch DG, Wu L, Abegg D, Martin BS, Zhang ZY, Adibekian A, Dai M. Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids. Journal of the American Chemical Society. PMID 30461272 DOI: 10.1021/Jacs.8B07652  0.34
2018 Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, et al. The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nature Communications. 9: 3259. PMID 30108215 DOI: 10.1038/S41467-018-05768-3  0.421
2018 Prabhu L, Chen L, Safa A, Korc M, Zhang Z, Lu T. Abstract 4862: Protein arginine methyltransferase 5 as a tumor promoter and therapeutic target in gastrointestinal cancers Cancer Research. 78: 4862-4862. DOI: 10.1158/1538-7445.Am2018-4862  0.33
2018 Chen H, Zhang S, Zhang Z, Wendt MK. Abstract 1959: Therapeutic rationale for SHP2 phosphatase inhibitors: Targeting drug-resistant breast cancer via blockade of FGFR1 signaling Cancer Research. 78: 1959-1959. DOI: 10.1158/1538-7445.Am2018-1959  0.365
2018 Kano Y, Gebregiworgis T, Marshall CB, Radulovich N, Poon BP, Zhang Z, Tsao M, Ikura M, Ohh M. 833 - Tyrosyl Phosphorylation of Kras Disrupts the Gtpase Cycle and Inhibits Pancreatic Cancer Cell Growth Gastroenterology. 154: S-173. DOI: 10.1016/S0016-5085(18)30991-0  0.322
2017 Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, et al. PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. Nature Communications. 8: 1060. PMID 29057934 DOI: 10.1038/S41467-017-01168-1  0.417
2017 Frankson R, Yu ZH, Bai Y, Li Q, Zhang RY, Zhang ZY. Therapeutic targeting of oncogenic tyrosine phosphatases. Cancer Research. PMID 28855209 DOI: 10.1158/0008-5472.CAN-17-1510  0.351
2017 Prabhu L, Wei H, Chen L, Demir Ö, Sandusky G, Sun E, Wang J, Mo J, Zeng L, Fishel M, Safa A, Amaro R, Korc M, Zhang ZY, Lu T. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. PMID 28591716 DOI: 10.18632/Oncotarget.18102  0.325
2017 Yu ZH, Zhang ZY. Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases. Chemical Reviews. PMID 28541680 DOI: 10.1021/Acs.Chemrev.7B00105  0.475
2017 Ruddraraju KV, Zhang ZY. Covalent inhibition of protein tyrosine phosphatases. Molecular Biosystems. PMID 28534914 DOI: 10.1039/C7Mb00151G  0.458
2017 Heckman CA, Pandey P, Cayer ML, Biswas T, Zhang ZY, Boudreau NS. The tumor promoter-activated protein kinase Cs are a system for regulating filopodia. Cytoskeleton (Hoboken, N.J.). PMID 28481056 DOI: 10.1002/Cm.21373  0.384
2016 Bai S, Ingram P, Chen YC, Deng N, Pearson A, Niknafs Y, O'Hayer P, Wang Y, Zhang ZY, Boscolo E, Bischoff J, Yoon E, Buckanovich RJ. EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Cancer Research. 76: 6396-6409. PMID 27803106 DOI: 10.1158/0008-5472.Can-16-0225  0.313
2016 He R, Wang J, Yu ZH, Zhang RY, Liu S, Wu L, Zhang ZY. Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. Journal of Medicinal Chemistry. PMID 27676368 DOI: 10.1021/Acs.Jmedchem.6B00993  0.428
2016 Li Y, Xia G, Guo Q, Wu L, Chen S, Yang Z, Wang W, Zhang ZY, Zhou X, Jiang ZX. Design, synthesis and evaluation of novel (19)F magnetic resonance sensitive protein tyrosine phosphatase inhibitors. Medchemcomm. 7: 1672-1680. PMID 27529021 DOI: 10.1039/C6Md00277C  0.318
2016 Bai Y, Yu ZH, Zhang ZY. Discovery and Evaluation of PRL Trimer Disruptors for Novel Anticancer Agents. Methods in Molecular Biology (Clifton, N.J.). 1447: 121-38. PMID 27514804 DOI: 10.1007/978-1-4939-3746-2_8  0.381
2016 Bai Y, Yu ZH, Liu S, Zhang L, Zhang RY, Zeng LF, Zhang S, Zhang ZY. Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase. Cancer Research. PMID 27325652 DOI: 10.1158/0008-5472.Can-15-2323  0.42
2016 Richine BM, Virts EL, Bowling JD, Ramdas B, Mali R, Naoye R, Liu Z, Zhang ZY, Boswell HS, Kapur R, Chan RJ. Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia. Leukemia. PMID 27256702 DOI: 10.1038/Leu.2016.131  0.391
2016 Wang J, Mizui M, Zeng LF, Bronson R, Finnell M, Terhorst C, Kyttaris VC, Tsokos GC, Zhang ZY, Kontaridis MI. Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. The Journal of Clinical Investigation. PMID 27183387 DOI: 10.1172/Jci87037  0.351
2016 Song GJ, Jung M, Kim JH, Park H, Rahman MH, Zhang S, Zhang ZY, Park DH, Kook H, Lee IK, Suk K. A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation. Journal of Neuroinflammation. 13: 86. PMID 27095436 DOI: 10.1186/S12974-016-0545-3  0.343
2016 Kobayashi M, Bai Y, Chen S, Nabinger SC, Yao C, Zhang Z, Liu Y. PRL2 Phosphatase Is a Key Mediator of Oncogenic Cytokine Signaling in Leukemia Stem Cells Blood. 128: 724-724. DOI: 10.1182/Blood.V128.22.724.724  0.413
2016 Kano Y, Bunda S, Yeh JJ, Zhang Z, Ohh M. Abstract B13: Novel treatment strategy for pancreatic cancer by targeting the ‘undruggable’ Ras oncoprotein Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B13  0.359
2015 He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Zhang ZY. Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis. Acs Medicinal Chemistry Letters. 6: 1231-5. PMID 26713110 DOI: 10.1021/Acsmedchemlett.5B00373  0.303
2015 He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY. A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. Bioorganic & Medicinal Chemistry. 23: 2798-809. PMID 25907364 DOI: 10.1016/J.Bmc.2015.03.066  0.341
2014 He RJ, Yu ZH, Zhang RY, Zhang ZY. Protein tyrosine phosphatases as potential therapeutic targets. Acta Pharmacologica Sinica. 35: 1227-46. PMID 25220640 DOI: 10.1038/aps.2014.80  0.314
2014 Yu ZH, Zhang RY, Walls CD, Chen L, Zhang S, Wu L, Liu S, Zhang ZY. Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry. 53: 4136-51. PMID 24935154 DOI: 10.1021/Bi5002695  0.753
2014 Zeng LF, Zhang RY, Bai Y, Wu L, Gunawan AM, Zhang ZY. Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta. Antioxidants & Redox Signaling. 20: 2130-40. PMID 24180557 DOI: 10.1089/ars.2013.5463  0.313
2013 Walls CD, Iliuk A, Bai Y, Wang M, Tao WA, Zhang ZY. Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Molecular & Cellular Proteomics : McP. 12: 3759-77. PMID 24030100 DOI: 10.1074/Mcp.M113.028886  0.755
2013 Dumaual CM, Steere BA, Walls CD, Wang M, Zhang ZY, Randall SK. Integrated analysis of global mRNA and protein expression data in HEK293 cells overexpressing PRL-1. Plos One. 8: e72977. PMID 24019887 DOI: 10.1371/Journal.Pone.0072977  0.725
2013 Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, et al. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of Biological Chemistry. 288: 17360-71. PMID 23640882 DOI: 10.1074/Jbc.M112.441469  0.323
2013 Zeng LF, Xu J, He Y, He R, Wu L, Gunawan AM, Zhang ZY. A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B. Chemmedchem. 8: 904-8. PMID 23568546 DOI: 10.1002/Cmdc.201300115  0.355
2013 Yu ZH, Xu J, Walls CD, Chen L, Zhang S, Zhang R, Wu L, Wang L, Liu S, Zhang ZY. Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations. The Journal of Biological Chemistry. 288: 10472-82. PMID 23457302 DOI: 10.1074/Jbc.M113.450023  0.712
2013 Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Zeng L, Richine B, Bowling JD, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky GE, Boswell HS, ... Zhang ZY, et al. The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia. 27: 398-408. PMID 23103841 DOI: 10.1038/leu.2012.308  0.313
2013 Meng FG, Zhang ZY. Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical. Biochimica Et Biophysica Acta. 1834: 464-9. PMID 22819876 DOI: 10.1016/J.Bbapap.2012.06.018  0.304
2013 He R, Zeng LF, He Y, Zhang S, Zhang ZY. Small molecule tools for functional interrogation of protein tyrosine phosphatases. The Febs Journal. 280: 731-50. PMID 22816879 DOI: 10.1111/j.1742-4658.2012.08718.x  0.365
2013 Kobayashi M, Dong Y, Yu H, Bai Y, Chen S, Gao R, Yoder MC, Kapur R, Zhang Z, Liu Y. PRL2 Maintains Hematopoietic Stem and Progenitor Cells Through Regulating SCF/KIT Signaling Blood. 122: 3674-3674. DOI: 10.1182/Blood.V122.21.3674.3674  0.39
2012 Zhang S, Chen L, Lawrence DS, Zhang ZY. A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors. Methods in Molecular Biology (Clifton, N.J.). 928: 53-65. PMID 22956133 DOI: 10.1007/978-1-62703-008-3_5  0.313
2012 Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, ... ... Zhang ZY, et al. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 120: 2669-78. PMID 22806893 DOI: 10.1182/Blood-2011-08-375873  0.319
2012 Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY. Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. The Journal of Biological Chemistry. 287: 32172-9. PMID 22791713 DOI: 10.1074/Jbc.M112.393462  0.316
2012 Negro R, Gobessi S, Longo PG, He Y, Zhang ZY, Laurenti L, Efremov DG. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood. 119: 6278-87. PMID 22569400 DOI: 10.1182/Blood-2012-01-403162  0.385
2012 Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann K, Roers A, Craig AW. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Molecular and Cellular Biology. 32: 2653-63. PMID 22566685 DOI: 10.1128/Mcb.00308-12  0.368
2012 Zheng LS, Zhang YY, Wu JW, Wu Z, Zhang ZY, Wang ZX. A continuous spectrophotometric assay for mitogen-activated protein kinase kinases. Analytical Biochemistry. 421: 191-7. PMID 22178908 DOI: 10.1016/J.Ab.2011.11.018  0.339
2012 He Y, Zeng LF, Yu ZH, He R, Liu S, Zhang ZY. Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors. Bioorganic & Medicinal Chemistry. 20: 1940-6. PMID 22133902 DOI: 10.1016/j.bmc.2011.11.004  0.329
2012 Loh K, Merry TL, Galic S, Wu BJ, Watt MJ, Zhang S, Zhang ZY, Neel BG, Tiganis T. T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice. Diabetologia. 55: 468-78. PMID 22124607 DOI: 10.1007/S00125-011-2386-Z  0.324
2012 Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Richine B, Bowling J, Fukuda S, Goenka S, Liu Z, Feng G, Yu M, Sandusky G, Boswell HS, Zhang Z, et al. The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells. Blood. 120: 2420-2420. DOI: 10.1182/Blood.V120.21.2420.2420  0.408
2011 Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, Zhang ZY. PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. The Journal of Biological Chemistry. 286: 42316-24. PMID 22009749 DOI: 10.1074/Jbc.M111.286302  0.747
2011 Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes & Development. 25: 2069-78. PMID 21979919 DOI: 10.1101/Gad.17224711  0.42
2011 Yu X, Chen M, Zhang S, Yu ZH, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, Zhang ZY. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate. The Journal of Biological Chemistry. 286: 30526-34. PMID 21719704 DOI: 10.1074/jbc.M111.254722  0.543
2011 Yu ZH, Chen L, Wu L, Liu S, Wang L, Zhang ZY. Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening. Bioorganic & Medicinal Chemistry Letters. 21: 4238-42. PMID 21669525 DOI: 10.1016/j.bmcl.2011.05.078  0.327
2011 Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry. 54: 1640-54. PMID 21341673 DOI: 10.1021/Jm101202J  0.315
2011 Liu S, Yu Z, Yu X, Huang SX, Luo Y, Wu L, Shen W, Yang Z, Wang L, Gunawan AM, Chan RJ, Shen B, Zhang ZY. SHP2 is a target of the immunosuppressant tautomycetin. Chemistry & Biology. 18: 101-10. PMID 21276943 DOI: 10.1016/J.Chembiol.2010.10.015  0.429
2011 Piovan L, Wu L, Zhang ZY, Andrade LH. Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases Organic and Biomolecular Chemistry. 9: 1347-1351. PMID 21240419 DOI: 10.1039/C0Ob01050B  0.444
2011 Ma P, Mali R, Zeng L, Martin H, Ramdas B, He Y, Sims E, Ghosh J, Nabinger SC, Li S, Munugalavadla V, Chatterjee A, Sandusky G, Craig A, Bunting KD, ... ... Zhang Z, et al. KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML Blood. 118: 868-868. DOI: 10.1182/Blood.V118.21.868.868  0.401
2011 Xu Y, Li H, Zhao Z, Antalis C, Emerson R, Zhang S, Zhang Z, Zhao Z, Gang W, Yan L, Cai Q. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment Cancer Research. 71: 3525-3525. DOI: 10.1158/1538-7445.Am2011-3525  0.323
2010 Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). Journal of Medicinal Chemistry. 53: 2482-93. PMID 20170098 DOI: 10.1021/Jm901645U  0.473
2009 Walls C, Zhou B, Zhang ZY. Activity-based protein profiling of protein tyrosine phosphatases. Methods in Molecular Biology (Clifton, N.J.). 519: 417-29. PMID 19381599 DOI: 10.1007/978-1-59745-281-6_27  0.75
2009 Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, ... ... Zhang ZY, et al. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Human Molecular Genetics. 18: 569-79. PMID 18981062 DOI: 10.1093/Hmg/Ddn363  0.326
2009 Nabinger SC, He Y, Yin F, Zhang X, Senbanjo L, Fukuda S, Yu M, Feng G, Zhang Z, Kapur R, Chan RJ. Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors. Blood. 114: 827-827. DOI: 10.1182/Blood.V114.22.827.827  0.367
2008 Liu S, Zeng LF, Wu L, Yu X, Xue T, Gunawan AM, Long YQ, Zhang ZY. Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. Journal of the American Chemical Society. 130: 17075-84. PMID 19012396 DOI: 10.1021/ja8068177  0.324
2008 Abdo M, Liu S, Zhou B, Walls CD, Wu L, Knapp S, Zhang ZY. Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases. Journal of the American Chemical Society. 130: 13196-7. PMID 18781746 DOI: 10.1021/Ja804489M  0.745
2008 Liu S, Zhou B, Yang H, He Y, Jiang ZX, Kumar S, Wu L, Zhang ZY. Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. Journal of the American Chemical Society. 130: 8251-60. PMID 18528979 DOI: 10.1021/Ja711125P  0.333
2008 Liang F, Luo Y, Dong Y, Walls CD, Liang J, Jiang HY, Sanford JR, Wek RC, Zhang ZY. Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase. The Journal of Biological Chemistry. 283: 10339-46. PMID 18268019 DOI: 10.1074/Jbc.M708285200  0.747
2007 Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America. 104: 19767-72. PMID 18056643 DOI: 10.1073/Pnas.0706233104  0.575
2007 Sun JP, Luo Y, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY. Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration. The Journal of Biological Chemistry. 282: 29043-51. PMID 17656357 DOI: 10.1074/jbc.M703537200  0.557
2007 Zhang S, Chen L, Kumar S, Wu L, Lawrence DS, Zhang ZY. An affinity-based fluorescence polarization assay for protein tyrosine phosphatases. Methods (San Diego, Calif.). 42: 261-7. PMID 17532513 DOI: 10.1016/J.Ymeth.2007.02.008  0.303
2007 Liang F, Kumar S, Zhang ZY. Proteomic approaches to studying protein tyrosine phosphatases. Molecular Biosystems. 3: 308-16. PMID 17460790 DOI: 10.1039/B700704N  0.357
2007 Liang F, Liang J, Wang WQ, Sun JP, Udho E, Zhang ZY. PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. The Journal of Biological Chemistry. 282: 5413-9. PMID 17192274 DOI: 10.1074/jbc.M608940200  0.552
2006 Kumar S, Zhou B, Liang F, Yang H, Wang WQ, Zhang ZY. Global analysis of protein tyrosine phosphatase activity with ultra-sensitive fluorescent probes. Journal of Proteome Research. 5: 1898-905. PMID 16889411 DOI: 10.1021/Pr050449X  0.32
2006 Liu S, Sun JP, Zhou B, Zhang ZY. Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3. Proceedings of the National Academy of Sciences of the United States of America. 103: 5326-31. PMID 16567630 DOI: 10.1073/pnas.0510506103  0.546
2006 Lee H, Xie L, Luo Y, Lee SY, Lawrence DS, Wang XB, Sotgia F, Lisanti MP, Zhang ZY. Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate. Biochemistry. 45: 234-40. PMID 16388599 DOI: 10.1021/Bi051560J  0.401
2005 Sun JP, Wang WQ, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry. 44: 12009-21. PMID 16142898 DOI: 10.1021/Bi0509191  0.521
2005 Lee K, Boovanahalli SK, Nam KY, Kang SU, Lee M, Phan J, Wu L, Waugh DS, Zhang ZY, No KT, Lee JJ, Burke TR. Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 4037-42. PMID 16039123 DOI: 10.1016/J.Bmcl.2005.06.027  0.353
2005 Liang F, Lee SY, Liang J, Lawrence DS, Zhang ZY. The role of protein-tyrosine phosphatase 1B in integrin signaling. The Journal of Biological Chemistry. 280: 24857-63. PMID 15866871 DOI: 10.1074/Jbc.M502780200  0.395
2004 Huang Z, Zhou B, Zhang ZY. Molecular determinants of substrate recognition in hematopoietic protein-tyrosine phosphatase. The Journal of Biological Chemistry. 279: 52150-9. PMID 15466470 DOI: 10.1074/Jbc.M407820200  0.49
2004 Kumar S, Zhou B, Liang F, Wang WQ, Huang Z, Zhang ZY. Activity-based probes for protein tyrosine phosphatases. Proceedings of the National Academy of Sciences of the United States of America. 101: 7943-8. PMID 15148367 DOI: 10.1073/pnas.0402323101  0.346
2004 Vetter SW, Zhang ZY. Combinatorial chemistry and peptide library methods to characterize protein phosphatases. Methods in Enzymology. 366: 260-82. PMID 14674254 DOI: 10.1016/S0076-6879(03)66020-9  0.372
2004 Zhang ZY. Mechanistic studies on protein tyrosine phosphatases. Progress in Nucleic Acid Research and Molecular Biology. 73: 171-220. PMID 12882518 DOI: 10.1016/S0079-6603(03)01006-7  0.332
2004 Zhang ZY. Chemical and mechanistic approaches to the study of protein tyrosine phosphatases. Accounts of Chemical Research. 36: 385-92. PMID 12809524 DOI: 10.1021/ar020122r  0.331
2003 Sun JP, Wu L, Fedorov AA, Almo SC, Zhang ZY. Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor Journal of Biological Chemistry. 278: 33392-33399. PMID 12810712 DOI: 10.1074/Jbc.M304693200  0.534
2003 Zhang J, Zhou B, Zheng CF, Zhang ZY. A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates. The Journal of Biological Chemistry. 278: 29901-12. PMID 12754209 DOI: 10.1074/Jbc.M303909200  0.45
2003 Wang WQ, Sun JP, Zhang ZY. An overview of the protein tyrosine phosphatase superfamily. Current Topics in Medicinal Chemistry. 3: 739-48. PMID 12678841 DOI: 10.2174/1568026033452302  0.602
2003 Sun JP, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY. Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. The Journal of Biological Chemistry. 278: 12406-14. PMID 12547827 DOI: 10.1074/Jbc.M212491200  0.524
2003 Zhang ZY, Zhou B, Xie L. Modulation of protein kinase signaling by protein phosphatases and inhibitors. Pharmacology & Therapeutics. 93: 307-17. PMID 12191622 DOI: 10.1016/S0163-7258(02)00199-7  0.501
2002 Vetter SW, Zhang ZY. Probing the phosphopeptide specificities of protein tyrosine phosphatases, SH2 and PTB domains with combinatorial library methods. Current Protein & Peptide Science. 3: 365-97. PMID 12370002 DOI: 10.2174/1389203023380594  0.41
2002 Zhou B, Wang ZX, Zhao Y, Brautigan DL, Zhang ZY. The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. The Journal of Biological Chemistry. 277: 31818-25. PMID 12082107 DOI: 10.1074/Jbc.M203969200  0.478
2002 Wang ZX, Zhou B, Wang QM, Zhang ZY. A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity. Biochemistry. 41: 7849-57. PMID 12056917 DOI: 10.1021/bi025776m  0.365
2002 Zhou B, Zhang ZY. The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop. The Journal of Biological Chemistry. 277: 13889-99. PMID 11839761 DOI: 10.1074/Jbc.M200377200  0.439
2002 Zhang ZY. Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development. Annual Review of Pharmacology and Toxicology. 42: 209-34. PMID 11807171 DOI: 10.1146/annurev.pharmtox.42.083001.144616  0.34
2001 Zhang ZY. Protein tyrosine phosphatases: prospects for therapeutics. Current Opinion in Chemical Biology. 5: 416-23. PMID 11470605 DOI: 10.1016/S1367-5931(00)00223-4  0.434
2001 Zhao Y, Zhang ZY. The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3. The Journal of Biological Chemistry. 276: 32382-91. PMID 11432864 DOI: 10.1074/jbc.M103369200  0.348
2000 Ibrahimi OA, Wu L, Zhao K, Zhang ZY. Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors Bioorganic and Medicinal Chemistry Letters. 10: 457-460. PMID 10743947 DOI: 10.1016/S0960-894X(00)00019-6  0.4
1999 Zhou B, Zhang Z. Mechanism of mitogen-activated protein kinase phosphatase-3 activation by ERK2. Journal of Biological Chemistry. 274: 35526-35534. PMID 10585426 DOI: 10.1074/Jbc.274.50.35526  0.445
1998 Sarmiento M, Zhao Y, Gordon SJ, Zhang ZY. Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B. The Journal of Biological Chemistry. 273: 26368-74. PMID 9756867 DOI: 10.1074/Jbc.273.41.26368  0.375
1998 Zhang YL, Keng YF, Zhao Y, Wu L, Zhang ZY. Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases. The Journal of Biological Chemistry. 273: 12281-7. PMID 9575179 DOI: 10.1074/Jbc.273.20.12281  0.456
1998 Zhang ZY. Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis. Critical Reviews in Biochemistry and Molecular Biology. 33: 1-52. PMID 9543627 DOI: 10.1080/10409239891204161  0.313
1998 Burke TR, Yao ZJ, Zhao H, Milne GWA, Wu L, Zhang Z, Voigt JH. Enantioselective Synthesis of Nonphosphorus-Containing Phosphotyrosyl Mimetics and Their Use in the Preparation of Tyrosine Phosphatase Inhibitory Peptides Tetrahedron. 54: 9981-9994. DOI: 10.1016/S0040-4020(98)00590-0  0.311
1997 Zhang Z, Ostanin K, Etten RLV. Covalent modification and site-directed mutagenesis of an active site tryptophan of human prostatic acid phosphatase. Acta Biochimica Polonica. 44: 659-672. DOI: 10.18388/Abp.1997_4368  0.393
1996 Zhang L, Zhang Z, Long F, Lee EY. Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins. Biochemistry. 35: 1606-11. PMID 8634292 DOI: 10.1021/bi9521396  0.312
1995 Zhang ZY. Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1. The Journal of Biological Chemistry. 270: 11199-204. PMID 7744751 DOI: 10.1074/Jbc.270.19.11199  0.334
1995 Zhang Z. Are protein-tyrosine phosphatases specific for phosphotyrosine? Journal of Biological Chemistry. 270: 16052-16055. DOI: 10.1074/Jbc.270.27.16052  0.317
1995 Yu L, McGill A, Ramirez J, Wang PG, Zhang Z. Synthesis and bioassay of a protein tyrosine phosphatase inhibitor, dephostatin Bioorganic & Medicinal Chemistry Letters. 5: 1003-1006. DOI: 10.1016/0960-894X(95)00156-N  0.355
1994 Zhang ZY, Wang Y, Dixon JE. Dissecting the catalytic mechanism of protein-tyrosine phosphatases Proceedings of the National Academy of Sciences of the United States of America. 91: 1624-1627. PMID 8127855 DOI: 10.1073/Pnas.91.5.1624  0.354
1994 Stuckey JA, Schubert HL, Fauman EB, Zhang ZY, Dixon JE, Saper MA. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate Nature. 370: 571-575. PMID 8052312 DOI: 10.1038/370571A0  0.322
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