Valerie S. LeBleu, Ph.D. - Publications

Affiliations: 
2009 Harvard University, Cambridge, MA, United States 
Area:
Cell Biology

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 McAndrews KM, LeBleu VS, Kalluri R. SIRT1 Regulates Lysosome Function and Exosome Secretion. Developmental Cell. 49: 302-303. PMID 31063745 DOI: 10.1016/j.devcel.2019.04.024  1
2019 LeBleu VS, Kalluri R. Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy. Immunity. 50: 547-549. PMID 30893584 DOI: 10.1016/j.immuni.2019.02.019  1
2018 Chen Y, Keskin D, Sugimoto H, Kanasaki K, Phillips PE, Bizarro L, Sharpe A, LeBleu VS, Kalluri R. Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis. Plos Biology. 16: e2005907. PMID 30592710 DOI: 10.1371/journal.pbio.2005907  1
2018 Parchem JG, Kanasaki K, Kanasaki M, Sugimoto H, Xie L, Hamano Y, Lee SB, Gattone VH, Parry S, Strauss JF, Garovic VD, McElrath TF, Lu KH, Sibai BM, LeBleu VS, et al. Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice. The Journal of Clinical Investigation. PMID 30179860 DOI: 10.1172/JCI99026  1
2018 Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Saur D, Kalluri R. Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program. Embo Molecular Medicine. PMID 30120146 DOI: 10.15252/emmm.201809085  1
2018 Eikesdal HP, Becker LM, Teng Y, Kizu A, Carstens JL, Kanasaki K, Sugimoto H, LeBleu VS, Kalluri R. BMP7 Signaling in TGFBR2-deficient Stromal Cells Provokes Epithelial Carcinogenesis. Molecular Cancer Research : McR. PMID 29934328 DOI: 10.1158/1541-7786.MCR-18-0120  1
2018 LeBleu VS, Kalluri R. A peek into cancer-associated fibroblasts: origins, functions and translational impact. Disease Models & Mechanisms. 11. PMID 29686035 DOI: 10.1242/dmm.029447  1
2018 Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, Marszalek JR, Maitra A, Yee C, Rezvani K, Shpall E, ... LeBleu VS, et al. Generation and testing of clinical-grade exosomes for pancreatic cancer. Jci Insight. 3. PMID 29669940 DOI: 10.1172/jci.insight.99263  1
2017 Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Ruivo CF, Melo SA, Lee JJ, Kalluri R. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. PMID 28607485 DOI: 10.1038/nature22341  1
2017 Carstens JL, Correa de Sampaio P, Yang D, Barua S, Wang H, Rao A, Allison JP, LeBleu VS, Kalluri R. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer. Nature Communications. 8: 15095. PMID 28447602 DOI: 10.1038/ncomms15095  1
2017 Kalluri R, LeBleu VS. Discovery of Double-Stranded Genomic DNA in Circulating Exosomes. Cold Spring Harbor Symposia On Quantitative Biology. PMID 28424339 DOI: 10.1101/sqb.2016.81.030932  1
2017 Yang S, Che SP, Kurywchak P, Tavormina JL, Gansmo LB, Correa de Sampaio P, Tachezy M, Bockhorn M, Gebauer F, Haltom AR, Melo SA, LeBleu VS, Kalluri R. Detection of Mutant KRAS and TP53 DNA in Circulating Exosomes from Healthy Individuals and Patients with Pancreatic Cancer. Cancer Biology & Therapy. 0. PMID 28121262 DOI: 10.1080/15384047.2017.1281499  1
2016 Kim J, de Sampaio PC, Lundy DM, Peng Q, Evans KW, Sugimoto H, Gagea M, Kienast Y, do Amaral NS, Rocha RM, Eikesdal HP, Lønning PE, Meric-Bernstam F, LeBleu VS. Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. Jci Insight. 1: e90733. PMID 28018977 DOI: 10.1172/jci.insight.90733  0.48
2016 Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine. PMID 27089513 DOI: 10.1038/nm.4082  0.88
2015 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, ... ... LeBleu VS, et al. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 28: 831-833. PMID 28843279 DOI: 10.1016/j.ccell.2015.11.002  1
2015 Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH. Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. Journal of Proteome Research. PMID 26595531 DOI: 10.1021/acs.jproteome.5b00675  1
2015 Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. PMID 26560028 DOI: 10.1038/nature16064  0.88
2015 Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nature Medicine. PMID 26236991 DOI: 10.1038/nm.3902  0.88
2015 Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. PMID 26106858 DOI: 10.1038/nature14581  0.88
2015 Keskin D, Kim J, Cooke VG, Wu CC, Sugimoto H, Gu C, De Palma M, Kalluri R, LeBleu VS. Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Reports. 10: 1066-81. PMID 25704811 DOI: 10.1016/j.celrep.2015.01.035  0.88
2014 LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nature Cell Biology. 16: 992-1003, 1-15. PMID 25241037 DOI: 10.1038/ncb3039  0.88
2014 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, ... ... LeBleu VS, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 25: 719-34. PMID 24856586 DOI: 10.1016/j.ccr.2014.04.005  0.88
2013 Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nature Medicine. 19: 810-1. PMID 23836214 DOI: 10.1038/nm.3081  0.88
2013 LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. Origin and function of myofibroblasts in kidney fibrosis. Nature Medicine. 19: 1047-53. PMID 23817022 DOI: 10.1038/nm.3218  0.88
2013 LeBleu VS, Teng Y, O'Connell JT, Charytan D, Müller GA, Müller CA, Sugimoto H, Kalluri R. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. Nature Medicine. 19: 227-31. PMID 23353556 DOI: 10.1038/nm.2989  0.88
2013 Borges FT, Melo SA, Özdemir BC, Kato N, Revuelta I, Miller CA, Gattone VH, LeBleu VS, Kalluri R. TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis. Journal of the American Society of Nephrology : Jasn. 24: 385-92. PMID 23274427 DOI: 10.1681/ASN.2012101031  0.88
2012 Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nature Medicine. 18: 396-404. PMID 22306733 DOI: 10.1038/nm.2629  0.88
2012 Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell. 21: 66-81. PMID 22264789 DOI: 10.1016/j.ccr.2011.11.024  0.88
2011 LeBleu VS, Kalluri R. Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis. Kidney International. 80: 1119-21. PMID 22083636 DOI: 10.1038/ki.2011.300  0.88
2011 O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, Neilson EG, Zeisberg M, Kalluri R. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proceedings of the National Academy of Sciences of the United States of America. 108: 16002-7. PMID 21911392 DOI: 10.1073/pnas.1109493108  0.88
2009 Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science (New York, N.Y.). 325: 167-71. PMID 19589995 DOI: 10.1126/science.1174294  0.88
2009 Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, et al. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (New York, N.Y.). 324: 626-31. PMID 19407199 DOI: 10.1126/science.1165069  0.88
2008 LeBleu VS, Kalluri R. Stem cell-based therapy for glomerular diseases: an evolving concept. Journal of the American Society of Nephrology : Jasn. 19: 1621-3. PMID 18701605 DOI: 10.1681/ASN.2008070735  0.88
2008 Lebleu VS, Sugimoto H, Miller CA, Gattone VH, Kalluri R. Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 284-92. PMID 18180701 DOI: 10.1038/labinvest.3700715  0.88
2008 Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH, Kalluri R. Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Developmental Biology. 313: 584-93. PMID 18082680 DOI: 10.1016/j.ydbio.2007.10.047  0.88
2007 LeBleu VS, Macdonald B, Kalluri R. Structure and function of basement membranes. Experimental Biology and Medicine (Maywood, N.J.). 232: 1121-9. PMID 17895520 DOI: 10.3181/0703-MR-72  0.88
2007 Sugimoto H, Yang C, LeBleu VS, Soubasakos MA, Giraldo M, Zeisberg M, Kalluri R. BMP-7 functions as a novel hormone to facilitate liver regeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 256-64. PMID 17116741 DOI: 10.1096/fj.06-6837com  0.88
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