| Year |
Citation |
Score |
| 2023 |
Wilken MB, Fonar G, Nations C, Pavani G, Tsao V, Garifallou J, Tober J, Bennett L, Maguire JA, Gagne A, Okoli N, Gadue P, Chou ST, Speck NA, French DL, et al. Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis. Biorxiv : the Preprint Server For Biology. PMID 37693628 DOI: 10.1101/2023.09.01.555861 |
0.38 |
|
| 2023 |
Ernst MPT, Pronk E, van Dijk C, van Strien PMH, van Tienhoven TVD, Wevers MJW, Sanders MA, Bindels EMJ, Speck NA, Raaijmakers MHGP. Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of -FPD. Hemasphere. 7: e824. PMID 36741355 DOI: 10.1097/HS9.0000000000000824 |
0.318 |
|
| 2022 |
Speck NA. A Pernicious Cycle Affecting Premalignant Stem Cells. The New England Journal of Medicine. 386: 596-598. PMID 35139279 DOI: 10.1056/NEJMcibr2117528 |
0.309 |
|
| 2022 |
Bennett LF, Mumau MD, Li Y, Speck NA. MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo. Development (Cambridge, England). PMID 35043940 DOI: 10.1242/dev.200025 |
0.362 |
|
| 2021 |
Howell ED, Yzaguirre AD, Gao P, Lis R, He B, Lakadamyali M, Rafii S, Tan K, Speck NA. Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes & Development. 35: 1475-1489. PMID 34675061 DOI: 10.1101/gad.348738.121 |
0.335 |
|
| 2021 |
Estevez B, Borst S, Jarocha DJ, Sudunagunta VS, Gonzalez M, Garifallou J, Hakonarson H, Gao P, Tan K, Liu PP, Bagga S, Holdreith N, Tong W, Speck NA, French DL, et al. RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells. Blood. PMID 33569577 DOI: 10.1182/blood.2020006389 |
0.352 |
|
| 2020 |
Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, ... ... Speck NA, et al. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32883883 DOI: 10.1073/Pnas.2003228117 |
0.497 |
|
| 2020 |
Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K. Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Genes & Development. PMID 32499402 DOI: 10.1101/Gad.338202.120 |
0.453 |
|
| 2020 |
Howell ED, Speck NA. Forks in the road to the first hematopoietic stem cells. Cell Research. PMID 32398861 DOI: 10.1038/S41422-020-0331-8 |
0.43 |
|
| 2020 |
Zhu Q, Gao P, Tober J, Bennett L, Chen C, Uzun Y, Li Y, Howell ED, Mumau M, Yu W, He B, Speck NA, Tan K. Developmental trajectory of pre-hematopoietic stem cell formation from endothelium. Blood. PMID 32392346 DOI: 10.1182/Blood.2020004801 |
0.495 |
|
| 2020 |
Yang W, Trahan GD, Howell ED, Speck NA, Jones KL, Gillen AE, Riemondy K, Hesselberth J, Bryder D, Ernst P. Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis. Stem Cell Reports. PMID 31951812 DOI: 10.1016/J.Stemcr.2019.12.009 |
0.472 |
|
| 2019 |
Chen C, Yu W, Tober J, Gao P, He B, Lee K, Trieu T, Blobel GA, Speck NA, Tan K. Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells. Cell Reports. 29: 4200-4211.e7. PMID 31851943 DOI: 10.1016/J.Celrep.2019.11.065 |
0.413 |
|
| 2019 |
Bennett L, Mumau M, Speck NA. Macrophages Fertilize the Soil to Promote Hematopoietic Cell Growth. Immunity. 50: 1342-1344. PMID 31216456 DOI: 10.1016/J.Immuni.2019.05.017 |
0.388 |
|
| 2019 |
Speck N, Zhu Q, Gao P, Tober J, Bennett L, Chen C, Uzun Y, Li Y, Tan K. Developmental Biology of the Blood System Blood. 134: SCI-29-SCI-29. DOI: 10.1182/Blood-2019-121283 |
0.451 |
|
| 2019 |
Howell E, He B, Lakadamyali M, Speck N, Tan K, Gao P, Yzaguirre A. 2010 - IDENTIFYING NECESSARY CHROMATIN STATES AND TARGETS FOR HEMOGENIC SPECIFICATION AND REPROGRAMMING Experimental Hematology. 76: S45. DOI: 10.1016/J.Exphem.2019.06.284 |
0.425 |
|
| 2018 |
Gao L, Tober J, Gao P, Chen C, Zhu Q, Tan K, Speck NA. RUNX1 and the endothelial origin of blood. Experimental Hematology. PMID 30391350 DOI: 10.1016/J.Exphem.2018.10.009 |
0.467 |
|
| 2018 |
Cai X, Zheng Y, Speck NA. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of Visualized Experiments : Jove. PMID 30199018 DOI: 10.3791/56855 |
0.455 |
|
| 2018 |
Yzaguirre AD, Howell ED, Li Y, Liu Z, Speck NA. Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis. Development (Cambridge, England). PMID 29361566 DOI: 10.1242/Dev.158162 |
0.466 |
|
| 2018 |
Zhu Q, Tober J, Li Y, Bennett L, Yzaguirre A, Gao P, Tan K, Speck NA. Hematopoietic cell formation in the major arteries of the mouse embryo Experimental Hematology. 64: S23. DOI: 10.1016/J.Exphem.2018.06.005 |
0.382 |
|
| 2017 |
Kulkeaw K, Inoue T, Iino T, Tani K, Akashi K, Speck NA, Nakanishi Y, Sugiyama D. Twist1 regulates embryonic hematopoietic differentiation through binding to Myb and Gata2 promoter regions. Blood Advances. 1: 1672-1681. PMID 29296814 DOI: 10.1182/Bloodadvances.2017006056 |
0.461 |
|
| 2017 |
Tober J, Maijenburg MMW, Li Y, Gao L, Hadland BK, Gao P, Minoura K, Bernstein ID, Tan K, Speck NA. Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1. The Journal of Experimental Medicine. PMID 29282253 DOI: 10.1084/Jem.20161594 |
0.366 |
|
| 2017 |
Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, Kwan W, Frost I, North TE, Rajewski RA, Speck NA, Bushweller JH. A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells. Leukemia & Lymphoma. 1-13. PMID 29249175 DOI: 10.1080/10428194.2017.1410882 |
0.476 |
|
| 2017 |
Zhen T, Kwon E, Zhao L, Hsu J, Hyde RK, Lu Y, Alemu L, Speck NA, Liu PP. CHD7 deficiency delays leukemogenesis in mice induced by CBFB-MYH11. Blood. PMID 29018080 DOI: 10.1182/Blood-2017-04-780106 |
0.394 |
|
| 2017 |
Li Y, Gao L, Hadland B, Tan K, Speck NA. CD27 marks murine embryonic hematopoietic stem cells and type II pre-hematopoietic stem cells. Blood. PMID 28588017 DOI: 10.1182/Blood-2017-03-776849 |
0.476 |
|
| 2017 |
Kim E, Cheng Y, Bolton-Gillespie E, Cai X, Ma C, Tarangelo A, Le L, Jambhekar M, Raman P, Hayer KE, Wertheim G, Speck NA, Tong W, Viatour P. Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression. The Journal of Experimental Medicine. PMID 28550162 DOI: 10.1084/Jem.20160719 |
0.424 |
|
| 2017 |
Lis R, Karrasch CC, Poulos MG, Kunar B, Redmond D, Duran JGB, Badwe CR, Schachterle W, Ginsberg M, Xiang J, Tabrizi AR, Shido K, Rosenwaks Z, Elemento O, Speck NA, et al. Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature. PMID 28514438 DOI: 10.1038/Nature22326 |
0.48 |
|
| 2017 |
Yzaguirre AD, de Bruijn MF, Speck NA. The Role of Runx1 in Embryonic Blood Cell Formation. Advances in Experimental Medicine and Biology. 962: 47-64. PMID 28299650 DOI: 10.1007/978-981-10-3233-2_4 |
0.482 |
|
| 2017 |
Lis R, Karrasch C, Poulos M, Kunar B, Redmond D, Duran JGB, Badwe C, Ginsberg M, Schachterle W, Xiang J, Tabrizi AR, Shido K, Rosenwaks Z, Elemento O, Speck N, et al. Conversion of adult endothelium into immune-competent haematopoietic stem cells Experimental Hematology. 53. DOI: 10.1016/J.Exphem.2017.06.183 |
0.363 |
|
| 2016 |
Speck NA. Stress Can Be a Good Thing for Blood Formation. Cell Stem Cell. 19: 279-80. PMID 27588740 DOI: 10.1016/J.Stem.2016.08.011 |
0.351 |
|
| 2016 |
Yzaguirre AD, Speck NA. Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 27389484 DOI: 10.1002/Dvdy.24430 |
0.43 |
|
| 2016 |
Tober J, Maijenburg MW, Speck NA. Taking the Leap: Runx1 in the Formation of Blood from Endothelium. Current Topics in Developmental Biology. 118: 113-62. PMID 27137656 DOI: 10.1016/Bs.Ctdb.2016.01.008 |
0.466 |
|
| 2016 |
Yzaguirre AD, Speck NA. Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos. Developmental Biology. PMID 27105579 DOI: 10.1016/J.Ydbio.2016.04.004 |
0.392 |
|
| 2016 |
Cai X, Hayashi Y, Wunderlich M, Speck NA, Mulloy JC, Huang G, Zheng Y. Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation Blood. 128: 3860-3860. DOI: 10.1182/Blood.V128.22.3860.3860 |
0.452 |
|
| 2016 |
Lis R, Harrasch C, Poulos MG, Duran JG, Schachterle W, Ginsberg M, Rafii A, Shido K, Speck NA, Butler JM, Scandura JM, Rafii S. Direct Conversion of Adult Endothelial Cells into Immunecompetent Long-Term Engraftable Clinically Scalable Hematopoietic Stem Cells: Pathway to Therapeutic Translation Blood. 128: 372-372. DOI: 10.1182/Blood.V128.22.372.372 |
0.482 |
|
| 2016 |
Lis R, Karrasch C, Poulos M, Barcia Duran JG, Schachterle W, Ginsberg M, Tabrizi AR, Shido K, Speck N, Butler J, Scandura J, Rafii S. Step-wise reprogramming of endothelial cells into immune-competent hematopoietic stem cells Experimental Hematology. 44: S48-S49. DOI: 10.1016/J.Exphem.2016.06.065 |
0.425 |
|
| 2016 |
Speck N. Expression and epigenomic profiling of embryonic hematopoiesis Experimental Hematology. 44: S37. DOI: 10.1016/J.Exphem.2016.06.035 |
0.301 |
|
| 2015 |
Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA. Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Elife. 4. PMID 26460546 DOI: 10.7554/Elife.07780 |
0.304 |
|
| 2015 |
Cai X, Gao L, Teng L, Ge J, Oo ZM, Kumar AR, Gilliland DG, Mason PJ, Tan K, Speck NA. Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 17: 165-77. PMID 26165925 DOI: 10.1016/J.Stem.2015.06.002 |
0.46 |
|
| 2015 |
Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg M, Phillips A, Speck NA, Wakitani S, Nakamura T, Yamada Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26097038 DOI: 10.1002/Art.39243 |
0.336 |
|
| 2015 |
Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Yzaguirre AD, Azzola L, Ng ES, Stanley EG, French DL, Cheng X, Gadue P, Speck NA, Elefanty AG, Keller G. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nature Cell Biology. 17: 580-91. PMID 25915127 DOI: 10.1038/Ncb3161 |
0.348 |
|
| 2015 |
Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP. The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding. The Journal of Biological Chemistry. 290: 7416-25. PMID 25605720 DOI: 10.1074/Jbc.M114.603753 |
0.332 |
|
| 2015 |
Tamplin OJ, Durand EM, Carr LA, Childs SJ, Hagedorn EJ, Li P, Yzaguirre AD, Speck NA, Zon LI. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 160: 241-52. PMID 25594182 DOI: 10.1016/J.Cell.2014.12.032 |
0.48 |
|
| 2014 |
Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, ... Speck NA, et al. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28: 2597-612. PMID 25395663 DOI: 10.1101/Gad.253302.114 |
0.405 |
|
| 2014 |
Satpathy AT, Briseño CG, Cai X, Michael DG, Chou C, Hsiung S, Bhattacharya D, Speck NA, Egawa T. Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Blood. 123: 2968-77. PMID 24677539 DOI: 10.1182/Blood-2013-11-539643 |
0.47 |
|
| 2014 |
Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, ... ... Speck N, et al. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes & Development. 28: 576-93. PMID 24637115 DOI: 10.1101/Gad.227496.113 |
0.476 |
|
| 2014 |
Imanirad P, Solaimani Kartalaei P, Crisan M, Vink C, Yamada-Inagawa T, de Pater E, Kurek D, Kaimakis P, van der Linden R, Speck N, Dzierzak E. HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo. Stem Cell Research. 12: 24-35. PMID 24141110 DOI: 10.1016/J.Scr.2013.09.006 |
0.502 |
|
| 2014 |
Li Y, Esain V, Teng L, Xu J, Frost I, Kwan W, Yzaguirre AD, Maijenberg MW, Orkin SH, Tan K, North TE, Speck NA. Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation Blood. 124: 2902-2902. DOI: 10.1182/Blood.V124.21.2902.2902 |
0.464 |
|
| 2014 |
Speck N, Li Y, Esain V, Teng L, Xu J, Phillips-Yzaguirre A, Maijenburg M, Dzierzak E, Orkin S, Tan K, North T. Inflammatory signaling regulates the number of lymphoid progenitors and HSCs in the embryo Experimental Hematology. 42: S5. DOI: 10.1016/J.Exphem.2014.07.018 |
0.314 |
|
| 2013 |
de Pater E, Kaimakis P, Vink CS, Yokomizo T, Yamada-Inagawa T, van der Linden R, Kartalaei PS, Camper SA, Speck N, Dzierzak E. Gata2 is required for HSC generation and survival. The Journal of Experimental Medicine. 210: 2843-50. PMID 24297996 DOI: 10.1084/Jem.20130751 |
0.471 |
|
| 2013 |
Tober J, Yzaguirre AD, Piwarzyk E, Speck NA. Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells. Development (Cambridge, England). 140: 3765-76. PMID 23924635 DOI: 10.1242/Dev.094961 |
0.466 |
|
| 2013 |
Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G. The expression of Sox17 identifies and regulates haemogenic endothelium. Nature Cell Biology. 15: 502-10. PMID 23604320 DOI: 10.1038/Ncb2724 |
0.462 |
|
| 2013 |
Richard C, Drevon C, Canto PY, Villain G, Bollérot K, Lempereur A, Teillet MA, Vincent C, Rosselló Castillo C, Torres M, Piwarzyk E, Speck NA, Souyri M, Jaffredo T. Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. Developmental Cell. 24: 600-11. PMID 23537631 DOI: 10.1016/J.Devcel.2013.02.011 |
0.415 |
|
| 2013 |
DeKelver RC, Yan M, Ahn EY, Shia WJ, Speck NA, Zhang DE. Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential. Blood. 121: 3714-7. PMID 23426948 DOI: 10.1182/Blood-2012-11-465641 |
0.427 |
|
| 2013 |
Hsu J, Huang H, Lee C, Yu S, Zon LI, Speck NA. Chromatin Remodeling Enzyme CHD7 Negatively Regulate Hematopoietic Stem Cell Function Blood. 122: 2413-2413. DOI: 10.1182/Blood.V122.21.2413.2413 |
0.53 |
|
| 2013 |
Kaimakis P, Eich C, de Pater E, van der Linden R, Speck N, Meijer D, Dzierzak E. Transcriptional control of hematopoiesis during embryonic development Experimental Hematology. 41: S44. DOI: 10.1016/J.Exphem.2013.05.175 |
0.317 |
|
| 2012 |
Chou ST, Byrska-Bishop M, Tober JM, Yao Y, Vandorn D, Opalinska JB, Mills JA, Choi JK, Speck NA, Gadue P, Hardison RC, Nemiroff RL, French DL, Weiss MJ. Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 17573-8. PMID 23045704 DOI: 10.1073/Pnas.1211175109 |
0.407 |
|
| 2012 |
Guo H, Ma O, Speck NA, Friedman AD. Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis. Blood. 119: 4408-18. PMID 22451420 DOI: 10.1182/Blood-2011-12-397091 |
0.486 |
|
| 2012 |
Soung do Y, Talebian L, Matheny CJ, Guzzo R, Speck ME, Lieberman JR, Speck NA, Drissi H. Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 1585-97. PMID 22431360 DOI: 10.1002/Jbmr.1601 |
0.768 |
|
| 2012 |
Hsu J, Huang H, Lee C, Yu S, Gerber S, Zon LI, Speck NA. CHD7 Negatively Regulates Hematopoietic Stem Cell Potency Blood. 120: 850-850. DOI: 10.1182/Blood.V120.21.850.850 |
0.51 |
|
| 2011 |
Mangan JK, Speck NA. RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making. Critical Reviews in Oncogenesis. 16: 77-91. PMID 22150309 DOI: 10.1615/Critrevoncog.V16.I1-2.80 |
0.317 |
|
| 2011 |
Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernst P, Speck NA. Runx1 loss minimally impacts long-term hematopoietic stem cells. Plos One. 6: e28430. PMID 22145044 DOI: 10.1371/Journal.Pone.0028430 |
0.809 |
|
| 2011 |
Chen MJ, Li Y, De Obaldia ME, Yang Q, Yzaguirre AD, Yamada-Inagawa T, Vink CS, Bhandoola A, Dzierzak E, Speck NA. Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell. 9: 541-52. PMID 22136929 DOI: 10.1016/J.Stem.2011.10.003 |
0.521 |
|
| 2011 |
Pajcini KV, Speck NA, Pear WS. Notch signaling in mammalian hematopoietic stem cells Leukemia. 25: 1525-1532. PMID 21647159 DOI: 10.1038/Leu.2011.127 |
0.445 |
|
| 2011 |
Hsu J, Lee C, Gerber S, Yu S, Speck NA. Runx1-Cbfb Interacts with CHD7, a Chromatin Modifying Enzyme with a Potential Role in Hematopoiesis Blood. 118: 1300-1300. DOI: 10.1182/Blood.V118.21.1300.1300 |
0.532 |
|
| 2010 |
Swiers G, de Bruijn M, Speck NA. Hematopoietic stem cell emergence in the conceptus and the role of Runx1. The International Journal of Developmental Biology. 54: 1151-63. PMID 20711992 DOI: 10.1387/Ijdb.103106Gs |
0.516 |
|
| 2010 |
Corpora T, Roudaia L, Oo ZM, Chen W, Manuylova E, Cai X, Chen MJ, Cierpicki T, Speck NA, Bushweller JH. Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity. Journal of Molecular Biology. 402: 560-77. PMID 20708017 DOI: 10.1016/J.Jmb.2010.08.007 |
0.389 |
|
| 2010 |
Sinenko SA, Hung T, Moroz T, Tran QM, Sidhu S, Cheney MD, Speck NA, Banerjee U. Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood. 116: 4612-20. PMID 20688956 DOI: 10.1182/Blood-2010-03-276998 |
0.399 |
|
| 2010 |
Speck NA, Vakoc CR. PAF is in the cabal of MLL1-interacting proteins that promote leukemia. Cancer Cell. 17: 531-2. PMID 20541697 DOI: 10.1016/J.Ccr.2010.05.019 |
0.379 |
|
| 2009 |
Hollenhorst PC, Chandler KJ, Poulsen RL, Johnson WE, Speck NA, Graves BJ. DNA specificity determinants associate with distinct transcription factor functions. Plos Genetics. 5: e1000778. PMID 20019798 DOI: 10.1371/Journal.Pgen.1000778 |
0.391 |
|
| 2009 |
Speck NA, Iruela-Arispe ML. Conditional Cre/LoxP strategies for the study of hematopoietic stem cell formation. Blood Cells, Molecules & Diseases. 43: 6-11. PMID 19250847 DOI: 10.1016/J.Bcmd.2009.01.010 |
0.428 |
|
| 2009 |
Park S, Chen W, Cierpicki T, Tonelli M, Cai X, Speck NA, Bushweller JH. Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity. Blood. 113: 3558-67. PMID 19204326 DOI: 10.1182/Blood-2008-06-161307 |
0.408 |
|
| 2009 |
Roudaia L, Cheney MD, Manuylova E, Chen W, Morrow M, Park S, Lee CT, Kaur P, Williams O, Bushweller JH, Speck NA. CBFbeta is critical for AML1-ETO and TEL-AML1 activity. Blood. 113: 3070-9. PMID 19179469 DOI: 10.1182/Blood-2008-03-147207 |
0.474 |
|
| 2009 |
Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature. 457: 887-91. PMID 19129762 DOI: 10.1038/Nature07619 |
0.78 |
|
| 2008 |
Roudaia L, Speck NA. A MENage à Trois in leukemia. Cancer Cell. 14: 3-5. PMID 18598937 DOI: 10.1016/J.Ccr.2008.06.009 |
0.328 |
|
| 2008 |
Guo Y, Maillard I, Chakraborti S, Rothenberg EV, Speck NA. Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification. Blood. 112: 480-92. PMID 18390836 DOI: 10.1182/Blood-2007-10-120261 |
0.504 |
|
| 2008 |
Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle (Georgetown, Tex.). 7: 586-91. PMID 18239455 DOI: 10.4161/Cc.7.5.5549 |
0.809 |
|
| 2008 |
Dzierzak E, Speck NA. Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nature Immunology. 9: 129-36. PMID 18204427 DOI: 10.1038/Ni1560 |
0.456 |
|
| 2008 |
Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nature Genetics. 40: 51-60. PMID 17994017 DOI: 10.1038/Ng.2007.7 |
0.43 |
|
| 2008 |
Speck NA, Chen M, Yokomizo T, Zeigler B, Dzierzak E. Runx1 Interactions in Stem Cell Biology. Blood. 112: sci-15-sci-15. DOI: 10.1182/Blood.V112.11.Sci-15.Sci-15 |
0.455 |
|
| 2007 |
Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chemistry & Biology. 14: 1186-97. PMID 17961830 DOI: 10.1016/J.Chembiol.2007.09.006 |
0.36 |
|
| 2007 |
Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH. Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell. 11: 483-97. PMID 17560331 DOI: 10.1016/J.Ccr.2007.04.010 |
0.781 |
|
| 2007 |
Matheny CJ, Speck ME, Cushing PR, Zhou Y, Corpora T, Regan M, Newman M, Roudaia L, Speck CL, Gu TL, Griffey SM, Bushweller JH, Speck NA. Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles. The Embo Journal. 26: 1163-75. PMID 17290219 DOI: 10.1038/Sj.Emboj.7601568 |
0.331 |
|
| 2007 |
Talebian L, Li Z, Guo Y, Gaudet J, Speck ME, Sugiyama D, Kaur P, Pear WS, Maillard I, Speck NA. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood. 109: 11-21. PMID 16940420 DOI: 10.1182/Blood-2006-05-021188 |
0.774 |
|
| 2007 |
Douvas MG, Roudaiya L, Grembecka J, Speck N, Bushweller J. Development of Allosteric Inhibitors of the Interaction of AML1 and CBFβ for the Treatment of Leukemia. Blood. 110: 653-653. DOI: 10.1182/Blood.V110.11.653.653 |
0.428 |
|
| 2007 |
Grembecka JE, Graf K, Kong Y, Douvas M, Cierpicki T, Illendula A, Baber G, Bielnicka I, Roudaia L, Speck NA, Brown ML, Bushweller JH. Development of Small Molecule Inhibitors of the AML1-ETO and CBFβ-SMMHC Oncoproteins. Blood. 110: 1591-1591. DOI: 10.1182/Blood.V110.11.1591.1591 |
0.386 |
|
| 2006 |
Li Z, Lukasik SM, Liu Y, Grembecka J, Bielnicka I, Bushweller JH, Speck NA. A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation. Journal of Molecular Biology. 364: 1073-83. PMID 17059830 DOI: 10.1016/J.Jmb.2006.10.002 |
0.389 |
|
| 2006 |
Zeigler BM, Sugiyama D, Chen M, Guo Y, Downs KM, Speck NA. The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential. Development (Cambridge, England). 133: 4183-92. PMID 17038514 DOI: 10.1242/Dev.02596 |
0.787 |
|
| 2006 |
Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH. The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. Cancer Cell. 9: 249-60. PMID 16616331 DOI: 10.1016/J.Ccr.2006.03.012 |
0.782 |
|
| 2006 |
Li Z, Chen MJ, Stacy T, Speck NA. Runx1 function in hematopoiesis is required in cells that express Tek. Blood. 107: 106-10. PMID 16174759 DOI: 10.1182/Blood-2005-05-1955 |
0.428 |
|
| 2005 |
Kundu M, Compton S, Garrett-Beal L, Stacy T, Starost MF, Eckhaus M, Speck NA, Liu PP. Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma. Blood. 106: 3621-4. PMID 16051740 DOI: 10.1182/Blood-2005-04-1447 |
0.47 |
|
| 2005 |
Growney JD, Shigematsu H, Li Z, Lee BH, Adelsperger J, Rowan R, Curley DP, Kutok JL, Akashi K, Williams IR, Speck NA, Gilliland DG. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood. 106: 494-504. PMID 15784726 DOI: 10.1182/Blood-2004-08-3280 |
0.428 |
|
| 2005 |
Sugiyama D, Sugiyama H, Speck NA. A Role for Twist in Thymocyte Development. Blood. 106: 4252-4252. DOI: 10.1182/Blood.V106.11.4252.4252 |
0.498 |
|
| 2005 |
Cheney MD, Liu Y, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH. Structural and Functional Characterization of the NHR2 and Runt Domains of AML1/ETO. Blood. 106: 2854-2854. DOI: 10.1182/Blood.V106.11.2854.2854 |
0.803 |
|
| 2005 |
Guo Y, Talebian L, Maillard I, Speck CL, Pear WS, Rothenberg EV, Speck NA. Reduction of Core Binding Factor beta (CBFβ) Dosage Blocks T Cell Development. Blood. 106: 2714-2714. DOI: 10.1182/Blood.V106.11.2714.2714 |
0.821 |
|
| 2005 |
Bushweller JH, Lukasik SM, Speck NA. The CBFb-SMMHC Oncoprotein Inhibits Binding of the Runx1 Runt Domain to DNA. Blood. 106: 2709-2709. DOI: 10.1182/Blood.V106.11.2709.2709 |
0.443 |
|
| 2005 |
Grembecka J, Graf K, Newman M, Zhou Y, Cheney M, Speck NA, Brown ML, Bushweller JH. Development of Small Molecule Inhibitor of the AML1-ETO Oncoprotein. Blood. 106: 1515-1515. DOI: 10.1182/Blood.V106.11.1515.1515 |
0.378 |
|
| 2005 |
Maillard I, Talebian L, Li Z, Guo Y, Sugiyama D, Speck ME, Pear WS, Speck NA. A Hypomorphic Cbfb Allele Reveals a Critical Dosage-Sensitive Function of Core Binding Factors at the Earliest Stages of T Cell Development. Blood. 106: 124-124. DOI: 10.1182/Blood.V106.11.124.124 |
0.819 |
|
| 2004 |
Yamashiro T, Wang XP, Li Z, Oya S, Aberg T, Fukunaga T, Kamioka H, Speck NA, Takano-Yamamoto T, Thesleff I. Possible roles of Runx1 and Sox9 in incipient intramembranous ossification. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 1671-7. PMID 15355562 DOI: 10.1359/Jbmr.040801 |
0.356 |
|
| 2004 |
Yan J, Liu Y, Lukasik SM, Speck NA, Bushweller JH. CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium. Nature Structural & Molecular Biology. 11: 901-6. PMID 15322525 DOI: 10.1038/Nsmb819 |
0.346 |
|
| 2004 |
de Bruijn MF, Speck NA. Core-binding factors in hematopoiesis and immune function. Oncogene. 23: 4238-48. PMID 15156179 DOI: 10.1038/Sj.Onc.1207763 |
0.435 |
|
| 2004 |
van Wijnen AJ, Stein GS, Gergen JP, Groner Y, Hiebert SW, Ito Y, Liu P, Neil JC, Ohki M, Speck N. Nomenclature for Runt-related (RUNX) proteins. Oncogene. 23: 4209-10. PMID 15156174 DOI: 10.1038/Sj.Onc.1207758 |
0.399 |
|
| 2004 |
North TE, Stacy T, Matheny CJ, Speck NA, de Bruijn MF. Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells. Stem Cells (Dayton, Ohio). 22: 158-68. PMID 14990855 DOI: 10.1634/Stemcells.22-2-158 |
0.487 |
|
| 2004 |
Huang G, Zhang P, Koschmieder S, Growney JD, Gilliland DG, Speck NA, Tenen DG. PU.1 Is a Critical Downstream Target of AML1. Blood. 104: 358-358. DOI: 10.1182/Blood.V104.11.358.358 |
0.486 |
|
| 2004 |
Talebian L, Li Z, Gallagher TL, Guo Y, Speck CL, Stacy T, Speck NA. A Hypomorphic Cbfb Allele Reveals Requirements for the Development of T Lymphocytes, Granulocytes, and Monocytes/Macrophages, and for Maintaining Proper Numbers of Hematopoietic Progenitors. Blood. 104: 1596-1596. DOI: 10.1182/Blood.V104.11.1596.1596 |
0.8 |
|
| 2003 |
Lian JB, Balint E, Javed A, Drissi H, Vitti R, Quinlan EJ, Zhang L, Wijnen AJV, Stein JL, Speck NA, Stein GS. Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo. Journal of Cellular Physiology. 196: 301-311. PMID 12811823 DOI: 10.1002/Jcp.10316 |
0.42 |
|
| 2003 |
Zhang L, Li Z, Yan J, Pradhan P, Corpora T, Cheney MD, Bravo J, Warren AJ, Bushweller JH, Speck NA. Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. The Journal of Biological Chemistry. 278: 33097-104. PMID 12807883 DOI: 10.1074/Jbc.M303972200 |
0.358 |
|
| 2003 |
Li Z, Yan J, Matheny CJ, Corpora T, Bravo J, Warren AJ, Bushweller JH, Speck NA. Energetic contribution of residues in the Runx1 Runt domain to DNA binding. The Journal of Biological Chemistry. 278: 33088-96. PMID 12807882 DOI: 10.1074/Jbc.M303973200 |
0.374 |
|
| 2003 |
Zhang L, Lukasik SM, Speck NA, Bushweller JH. Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC. Blood Cells, Molecules & Diseases. 30: 147-56. PMID 12732176 DOI: 10.1016/S1079-9796(03)00022-6 |
0.322 |
|
| 2002 |
Miller J, Horner A, Stacy T, Lowrey C, Lian JB, Stein G, Nuckolls GH, Speck NA. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Nature Genetics. 32: 645-9. PMID 12434155 DOI: 10.1038/Ng1049 |
0.358 |
|
| 2002 |
Lukasik SM, Zhang L, Corpora T, Tomanicek S, Li Y, Kundu M, Hartman K, Liu PP, Laue TM, Biltonen RL, Speck NA, Bushweller JH. Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis. Nature Structural Biology. 9: 674-9. PMID 12172539 DOI: 10.1038/Nsb831 |
0.334 |
|
| 2002 |
Speck NA, Gilliland DG. Core-binding factors in haematopoiesis and leukaemia. Nature Reviews. Cancer. 2: 502-13. PMID 12094236 DOI: 10.1038/Nrc840 |
0.38 |
|
| 2002 |
Lacaud G, Gore L, Kennedy M, Kouskoff V, Kingsley P, Hogan C, Carlsson L, Speck N, Palis J, Keller G. Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood. 100: 458-66. PMID 12091336 DOI: 10.1182/Blood-2001-12-0321 |
0.475 |
|
| 2002 |
North TE, de Bruijn MF, Stacy T, Talebian L, Lind E, Robin C, Binder M, Dzierzak E, Speck NA. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity. 16: 661-72. PMID 12049718 DOI: 10.1016/S1074-7613(02)00296-0 |
0.818 |
|
| 2002 |
Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N, Groner Y. Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mechanisms of Development. 109: 413-7. PMID 11731260 DOI: 10.1016/S0925-4773(01)00537-8 |
0.358 |
|
| 2001 |
Speck NA. Core binding factor and its role in normal hematopoietic development. Current Opinion in Hematology. 8: 192-6. PMID 11561154 DOI: 10.1097/00062752-200107000-00002 |
0.468 |
|
| 2001 |
Miller JD, Stacy T, Liu PP, Speck NA. Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells. Blood. 97: 2248-56. PMID 11290585 DOI: 10.1182/Blood.V97.8.2248 |
0.525 |
|
| 2000 |
Tracey WD, Speck NA. Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate. Seminars in Cell & Developmental Biology. 11: 337-42. PMID 11105897 DOI: 10.1006/Scdb.2000.0186 |
0.469 |
|
| 2000 |
Tang YY, Shi J, Zhang L, Davis A, Bravo J, Warren AJ, Speck NA, Bushweller JH. Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha. The Journal of Biological Chemistry. 275: 39579-88. PMID 10984496 DOI: 10.1074/Jbc.M007350200 |
0.404 |
|
| 2000 |
de Bruijn MF, Speck NA, Peeters MC, Dzierzak E. Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo. The Embo Journal. 19: 2465-74. PMID 10835345 DOI: 10.1093/Emboj/19.11.2465 |
0.432 |
|
| 2000 |
Tang YY, Crute BE, Kelley JJ, Huang X, Yan J, Shi J, Hartman KL, Laue TM, Speck NA, Bushweller JH. Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA. Febs Letters. 470: 167-72. PMID 10734228 DOI: 10.1016/S0014-5793(00)01312-0 |
0.339 |
|
| 2000 |
Gu TL, Goetz TL, Graves BJ, Speck NA. Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1). Molecular and Cellular Biology. 20: 91-103. PMID 10594012 DOI: 10.1128/Mcb.20.1.91-103.2000 |
0.361 |
|
| 2000 |
Goetz TL, Gu TL, Speck NA, Graves BJ. Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2. Molecular and Cellular Biology. 20: 81-90. PMID 10594011 DOI: 10.1128/Mcb.20.1.81-90.2000 |
0.36 |
|
| 2000 |
de Bruijn MFTR, Peeters MCE, Luteijn T, Visser P, Speck NA, Dzierzak E. CFU-S11 activity does not localize solely with the aorta in the aorta-gonad-mesonephros region Blood. 96: 2902-2904. DOI: 10.1182/Blood.V96.8.2902.H8002902_2902_2904 |
0.309 |
|
| 1999 |
Berardi MJ, Sun C, Zehr M, Abildgaard F, Peng J, Speck NA, Bushweller JH. The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains Structure. 7: 1247-1256. PMID 10545320 DOI: 10.1016/S0969-2126(00)80058-1 |
0.424 |
|
| 1999 |
Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, ... ... Speck NA, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nature Genetics. 23: 166-75. PMID 10508512 DOI: 10.1038/13793 |
0.335 |
|
| 1999 |
Huang X, Peng JW, Speck NA, Bushweller JH. Solution structure of core binding factor beta and map of the CBF alpha binding site. Nature Structural Biology. 6: 624-7. PMID 10404216 DOI: 10.1038/10670 |
0.325 |
|
| 1999 |
Lewis AF, Stacy T, Green WR, Taddesse-Heath L, Hartley JW, Speck NA. Core-binding factor influences the disease specificity of Moloney murine leukemia virus. Journal of Virology. 73: 5535-47. PMID 10364302 DOI: 10.1128/Jvi.73.7.5535-5547.1999 |
0.37 |
|
| 1998 |
Adya N, Stacy T, Speck NA, Liu PP. The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates. Molecular and Cellular Biology. 18: 7432-43. PMID 9819429 DOI: 10.1128/Mcb.18.12.7432 |
0.414 |
|
| 1998 |
Erman B, Cortes M, Nikolajczyk BS, Speck NA, Sen R. ETS-core binding factor: A common composite motif in antigen receptor gene enhancers Molecular and Cellular Biology. 18: 1322-1330. PMID 9488447 DOI: 10.1128/Mcb.18.3.1322 |
0.442 |
|
| 1998 |
Huang X, Speck N, Bushweller J. Complete Heteronuclear NMR Resonance Assignments, Secondary Structure, and Mapping of Core Binding Factor a Binding Site for Core Binding Factor b (1-141) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr4092 |
0.32 |
|
| 1997 |
Cao W, Britos-Bray M, Claxton DF, Kelley CA, Speck NA, Liu PP, Friedman AD. CBFβ-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells Oncogene. 15: 1315-1327. PMID 9315100 DOI: 10.1038/Sj.Onc.1201305 |
0.422 |
|
| 1997 |
Yergeau DA, Hetherington CJ, Wang Q, Zhang P, Sharpe AH, Binder M, Marín-Padilla M, Tenen DG, Speck NA, Zhang DE. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nature Genetics. 15: 303-6. PMID 9054947 DOI: 10.1038/Ng0397-303 |
0.452 |
|
| 1997 |
Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marín-Padilla M, Sharpe AH, ... Speck NA, et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 87: 697-708. PMID 8929538 DOI: 10.1016/S0092-8674(00)81389-6 |
0.391 |
|
| 1996 |
Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M, Marín-Padilla M, Collins FS, Wynshaw-Boris A, Liu PP. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell. 87: 687-96. PMID 8929537 DOI: 10.1016/S0092-8674(00)81388-4 |
0.438 |
|
| 1996 |
Crute BE, Lewis AF, Wu Z, Bushweller JH, Speck NA. Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain. The Journal of Biological Chemistry. 271: 26251-60. PMID 8824275 DOI: 10.1074/Jbc.271.42.26251 |
0.367 |
|
| 1996 |
Wang Q, Stacy T, Binder M, Marín-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis Proceedings of the National Academy of Sciences of the United States of America. 93: 3444-3449. PMID 8622955 DOI: 10.1073/Pnas.93.8.3444 |
0.376 |
|
| 1995 |
Hajra A, Liu PP, Wang Q, Kelley CA, Stacy T, Adelstein RS, Speck NA, Collins FS. The leukemic core binding factor β-smooth muscle myosin heavy chain (CBFβ-SMMHC) chimeric protein requires both CBFβ and myosin heavy chain domains for transformation of NIH 3T3 cells Proceedings of the National Academy of Sciences of the United States of America. 92: 1926-1930. PMID 7892201 DOI: 10.1073/Pnas.92.6.1926 |
0.416 |
|
| 1995 |
Zaiman AL, Lewis AF, Crute BE, Speck NA, Lenz J. Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores. Journal of Virology. 69: 2898-906. PMID 7707514 DOI: 10.1128/Jvi.69.5.2898-2906.1995 |
0.387 |
|
| 1995 |
Sun W, Graves BJ, Speck NA. Transactivation of the Moloney murine leukemia virus and T-cell receptor β-chain enhancers by cbf and ets requires intact binding sites for both proteins Journal of Virology. 69: 4941-4949. PMID 7609063 DOI: 10.1128/Jvi.69.8.4941-4949.1995 |
0.392 |
|
| 1995 |
Wijmenga C, Speck NA, Dracopoli NC, Hofker MH, Liu P, Collins FS. Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter. Genomics. 26: 611-4. PMID 7607690 DOI: 10.1016/0888-7543(95)80185-O |
0.322 |
|
| 1994 |
Wotton D, Ghysdael J, Wang S, Speck NA, Owen MJ. Cooperative binding of Ets-1 and core binding factor to DNA Molecular and Cellular Biology. 14: 840-850. PMID 8264651 DOI: 10.1128/Mcb.14.1.840 |
0.368 |
|
| 1994 |
Liu P, Seidel N, Bodine D, Speck N, Tarlé S, Collins FS. Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail. Cold Spring Harbor Symposia On Quantitative Biology. 59: 547-53. PMID 7587111 DOI: 10.1101/Sqb.1994.059.01.061 |
0.305 |
|
| 1993 |
Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Molecular and Cellular Biology. 13: 3324-39. PMID 8497254 DOI: 10.1128/Mcb.13.6.3324 |
0.354 |
|
| 1993 |
Melnikova IN, Crute BE, Wang S, Speck NA. Sequence specificity of the core-binding factor. Journal of Virology. 67: 2408-11. PMID 8445737 DOI: 10.1128/Jvi.67.4.2408-2411.1993 |
0.338 |
|
| 1993 |
Sun W, O'Connell M, Speck NA. Characterization of a protein that binds multiple sequences in mammalian type C retrovirus enhancers. Journal of Virology. 67: 1976-86. PMID 8445719 DOI: 10.1128/Jvi.67.4.1976-1986.1993 |
0.334 |
|
| 1993 |
Manley NR, O'Connell M, Sun W, Speck NA, Hopkins N. Two factors that bind to highly conserved sequences in mammalian type C retroviral enhancers. Journal of Virology. 67: 1967-75. PMID 8445718 DOI: 10.1128/Jvi.67.4.1967-1975.1993 |
0.374 |
|
| 1992 |
Prosser HM, Wotton D, Gegonne A, Ghysdael J, Wang S, Speck NA, Owen MJ. A phorbol ester response element within the human T-cell receptor β-chain enhancer Proceedings of the National Academy of Sciences of the United States of America. 89: 9934-9938. PMID 1409722 DOI: 10.1073/Pnas.89.20.9934 |
0.405 |
|
| 1992 |
Redondo JM, Pfohl JL, Hernandez-Munain C, Wang S, Speck NA, Krangel MS. Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers. Molecular and Cellular Biology. 12: 4817-23. PMID 1328863 DOI: 10.1128/Mcb.12.11.4817 |
0.443 |
|
| 1992 |
Wang SW, Speck NA. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Molecular and Cellular Biology. 12: 89-102. PMID 1309596 DOI: 10.1128/Mcb.12.1.89 |
0.351 |
|
| 1990 |
Speck NA, Renjifo B, Golemis E, Fredrickson TN, Hartley JW, Hopkins N. Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity. Genes & Development. 4: 233-42. PMID 2338244 DOI: 10.1101/Gad.4.2.233 |
0.305 |
|
| 1990 |
Renjifo B, Speck NA, Winandy S, Hopkins N, Li Y. cis-acting elements in the U3 region of a simian immunodeficiency virus. Journal of Virology. 64: 3130-4. PMID 2335831 DOI: 10.1128/Jvi.64.6.3130-3134.1990 |
0.347 |
|
| 1990 |
Golemis EA, Speck NA, Hopkins N. Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design. Journal of Virology. 64: 534-42. PMID 2153223 DOI: 10.1128/Jvi.64.2.534-542.1990 |
0.303 |
|
| 1990 |
Speck NA, Renjifo B, Hopkins N. Point mutations in the Moloney murine leukemia virus enhancer identify a lymphoid-specific viral core motif and 1,3-phorbol myristate acetate-inducible element. Journal of Virology. 64: 543-50. PMID 2104942 DOI: 10.1128/Jvi.64.2.543-550.1990 |
0.4 |
|
| 1987 |
Speck NA, Baltimore D. Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer. Molecular and Cellular Biology. 7: 1101-10. PMID 3561410 DOI: 10.1128/Mcb.7.3.1101 |
0.361 |
|
| 1982 |
Speck NA, Pierce SK. The induction of B cells refractory to antibody-specific immunoregulation European Journal of Immunology. 12: 449-452. PMID 6980129 DOI: 10.1002/Eji.1830120518 |
0.364 |
|
| 1982 |
Speck NA, Pierce SK. Antibody-specific immunoregulation is restricted by the major histocompatibility gene complex European Journal of Immunology. 12: 972-976. PMID 6217979 DOI: 10.1002/Eji.1830121114 |
0.372 |
|
| 1982 |
Speck NA, Pierce SK. The collaborative phenotype of secondary B cells is determined by T lymphocytes during in vivo immunization Journal of Experimental Medicine. 155: 574-586. PMID 6173458 DOI: 10.1084/Jem.155.2.574 |
0.383 |
|
| 1981 |
Pierce SK, Speck NA, Gleason K, Gearhart PJ, Köhler H. BALB/c T cells have the potential to recognize the TEPC 15 prototype antibody and its somatic variants Journal of Experimental Medicine. 154: 1178-1187. PMID 6974760 DOI: 10.1084/Jem.154.4.1178 |
0.369 |
|
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